Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
1477 (aa); 163 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(3)mbt using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\l(3)mbt in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of l(3)mbt causes dorsal overextension of primary dendrites in ddaD and ddaE neurons. For such neurons, the most distal branchpoint is located 25 microns or further from the distal tip of the primary dendrite. However, branching of these dendrites is reduced. RNAi also causes defects in muscle and defects in dendrite morphogenesis.
l(3)mbt is a temperature-dependent tumor suppressor gene. Deletion strains at normal temperatures show lethality of males but viability of (sterile) females with variable defects of the wings. Raising at 29oC leads to 100% larval lethality and enormous brain tumors.
l(3)mbt gene is identified, sequenced and is shown to encode a putative Pro-rich protein of 1477 amino acids with a novel zinc finger.
Mutants display a brain neoplastic phenotype.