transcription factor - AML-1 homolog - involved in sensillogenesis in antenna - mutants lack basiconic sensilla and some trichoid sensilla - the presence of Lz in R3/4 precluster cells is sufficient to endow them with a second wave cell fate response repertoire
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.52
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lz using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\lz in GBrowse 2
The lz region has been subdivided into four recombinationally separable groups of alleles; recombination is observed between but not within groups. Not all alleles have been mapped. The total genetic length of the region is 0.14 cM.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: lz CG1689
lz is required during stages 10 to 14 of embryogenesis for crystal cell development, and later during larval stages to replenish lost crystal cells.
lz acts in a dose-dependent manner to specify the fate of the sensilla trichoidea and sensilla basiconica in the antenna.
lz participates in the regulatory hierarchy of eye development by specifying cell fates for several cell types, promoting non-neuronal cell fates of cone and pigment cells over the neuronal fates. Developmental basis of the lz eye phenotype can be attributed to changes in cell identity and recruitment.
Lack of lz function causes a change in cone cell fate inducing them to take on a neuronal identity.
lz functions as a negative regulator of svp in R7 and cone cell precursors. lz controls svp and B expression in the developing eye disc, helping to define the fate of cells that arise from the second wave of mitotic division (R1/R6, R7 and cone cells).
lz may play a permissive role in allowing the non-neuronal support cells (cone or pigment cells) to choose their fate.
Mutations in lz cause a pleiotropic range of phenotypes including severe morphological defects in the compound eye. These defects are associated with altered patterns of cell birth and cell death occurring during critical periods of cell-cell interactions with recruitment.
Alleles show a wide range of phenotypes. Eyes variably reduced in size and often ovoid in shape. Surface with fused facets producing a roughened glistening appearance (= glossy), or smooth with pigment either uniformly distributed or concentrated at periphery of the eye (= spectacle). Tarsal claws reduced to different extents by different alleles. Females often sterile, but sterility appears to be primarily an ovarian defect, since some genotypes which lack parovaria and spermathecae are female fertile. Some alleles lack the class of hemocytes called crystal cells, or at least lack the crystalline inclusions of those cells; the inclusions can be shown to comprise prophenoloxidase and flies lacking crystal cells are deficient in phenol oxidase activity and suppress the phenotype of Bc. Double mutants produced by recombination all have the extreme phenotype of lzs.
It has been postulated that lz+ crucial to differentiation of crystal cells and is not a structural gene for any of the five phenol oxidase moieties.
Behavioural data suggests antennal and maxillary basiconic sensilla may be important receptors for short chain alcohols and organic acids but less crucial for acetates, aldehydes and ketones.
The lz mutant phenotype and the loss of maxillary basiconic sensilla have only subtle effects on the behaviours induced by esters and carbonyl compounds.
Mutants in lz cause the loss of prophenoloxidase activity. Encapsulation of eggs from the parasitoid strain L.boulardi demonstrate that phenoloxidases are required only for blackening and hardening of haemolytic capsules.
Mating studies of lz mutants suggests that antennal basiconic sensilla are important for neither the perception of the attraction pheromones of virgin females nor the inhibitory pheromone of mated females.
Spermathecae and parovaria (= accessory glands) often missing in homozygotes with abnormal parovaria seen in some heterozygous females.
Eye pigment variably reduced and Malpighian tubes slightly lighter than normal.