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FB2026_01
,
released March 12, 2026
Cdc25, twn, BG:DS02740.1 , l(2)35Fh, mat(2)synHB5
cdc25 phosphatase - dephosphorylation of cdc2 by Twine controls entry into meiosis in both males and females
Please see the JBrowse view of Dmel\twe for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.44
Gene model reviewed during 5.55
2 (northern blot)
1.738 (longest cDNA)
431 (aa)
395 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\twe using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
twe transcripts are expressed maximally in nurse cells in the later stages of oogenesis and the transcripts are transferred to the oocyte from stage 11 onward. The maternally derived transcripts are uniformly distributed in the cytoplasm of the early embryo and are excluded from the forming cells during cellularization. twe transcripts are also expressed in the male testis where they accumulate in the growing phase of spermatocytes. No zygotic twe transcription was detected.
twe expression is restricted to male and female gonads. In the ovary, twe is first detected in stage S7 nurse cells and is detected at high levels by stage S10. At stage S11, transcripts are translocated from the nurse cells to the oocyte. twe signal remains strong in early embryos up through cellularization. In the testis, no expression is observed in the apical tip where the mitotic divisions occur but rather in the premeiotic cyst of 16 primary spermatocytes and also after meiosis I in the 32-cell cysts.
JBrowse - Visual display of RNA-Seq signals
View Dmel\twe in JBrowse2-52
2-49.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
da and crp are two independent DNA-binding components of Sebp3, a protein complex that appears to be required for the transcriptional activation of Sgs4. Since Sebp3 binding activity is specific for the salivary gland, and da and crp are ubiquitously expressed, the Sebp3 complex probably contains additional protein(s). In direction of increasing cytology: twe- crp- pkaap+
"l(2)35Fh" gene is inferred from the lethality of In(2L)el18/Df(2L)RN2 - they should only overlap for twe but twe is not a lethal.
twe is essential during oogenesis and has a role in regulating mitosis in the syncytial embryo stage.
twe gene identified on basis of sequence similarity to cdc25 phosphatases by PCR with degenerate primers.
Mutant embryos show defects occurring during syncytial blastoderm formation: cytoplasmic clearing appears irregular.
Source for merge of: twe l(2)35Fh
Can rescue allele 22 of Spom\cdc25, but not a deletion of the gene.
Source for identity of: twe CG4965
