BAP155, Moi, brahma-associated protein 155
Trithorax-complex protein - SWI3 homolog - chromatin remodeling protein - functions as the Swi3 component of the Brahma complex - GAF (Trithorax-like) and Moira interact directly with Yorkie
Gene model reviewed during 5.54
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mor using the Feature Mapper tool.
mor transcripts are detected by northern blot at 0-4hr of embryogenesis, reach a peak in 4-8hr embryos and decline until the 2nd instar larval stage. The are expressed also in third instar larvae, pupae, and adult males and females. mor transcripts are ubiquitously expressed in early embryos as assayed by in situ hybridization. They are enriched in the CNS, midgut and hindgut of older embryos.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mor in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
Pc, Scm, Psc, ph-p and ph-d contribute to the PRC1 (Polycomb repressive complex 1). PRC1 directly antagonizes ATP-dependent remodeling of nucleosomal arrays in a purified system and may directly modulate (and be modified by) SWI/SNF (brm/mor) activity.
mor is required for the function of multiple homeotic genes in most imaginal tissues.
mor is an essential gene necessary for the transcriptional regulation of multiple homeotic and segmentation genes. Germline clonal analysis demonstrates that mor is important for proper oogenesis and somatic clonal analysis demonstrates that mor is required for the correct differentiation of imaginal structures in the adult cuticle.
Isolated as a dominant suppressor of the antenna-to-leg transformation in a Pc2 AntpNs double heterozygote. Strongly suppresses the antennal transformation in an AntpNs heterozygote, but does not suppress the antennal transformation in a strain containing a heat-shock driven Antp cDNA. Also behaves as a dominant suppressor of Pc and Pcl mutations. All alleles associated with a common recessive embryonic lethality. Mitotic clones induced during larval growth lead to transformation of haltere tissue to wing tissue. Ubx130/mor has low frequency of haltere to wing transformation.
mor is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of AntpScx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not. Mosaic analysis with mutant alleles reveals homeotic transformations in adult cuticle.
"Moira" means "fate" in Greek.