Acp70A, ACP, DrmSP, Accessory gland protein 70A
male ejaculate accessory gland protein transferred to females during mating - decreases female receptivity and stimulates egg production in the first mating of virgin females - decreases receptivity to mating, changes in juvenile hormone levels, in longevity and in sperm release from storage, and in feeding, digestion, and activity
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.56
There is only one protein coding transcript and one polypeptide associated with this gene
Sperm-bound protein is cleaved to release an active C-terminal peptide. Gradual release from stored sperm may function to prolong PMR and enhance male reproductive success.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SP using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\SP in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In matings with virgin females, Acp70A protein transfer increases mating productivity and delays remating and hence the onset of sperm competition. In already mated females, Acp70A protein transfer does not elevate absolute progeny production, but does increase intermating intervals and hence the period over which a male can gain paternity. Consistent with this, under free-mating conditions over an extended period, a "per-mating" fitness benefit is detected for males transferring Acp70A protein.
Application of methoprene mimics the Acp70A product-mediated stimulation of vitellogenic oocyte progression in sexually mature virgin females.
Females are capable of repelling males be emitting a volatile pheromone(s) with an inhibitory effect on male courtship.
In a screen of 204 randomly selected Scer\GAL4 enhancer trap lines 33 give rise to Sex Peptide responses, but none separate the behavioural and physiological responses. These results indicate that the two responses are either identical, very close together or in two anatomically distinct tissues expression a common set of genes.
Chromosome homologies of Muller's element D (J chromosome in the Paleartic species and XR chromosome arm in Nearctic species) and of element E (O chromosome in the Paleartic species and 2 chromosome in Nearctic species) have been confirmed by single copy probes in the species of the obscura group and in D.melanogaster.
Injection of Acp70A or ectopic expression of Acp70A in virgin females causes reduced receptivity and increased ovulation and oviposition. These behavioural changes suggest that the nervous system is involved in females' reaction to Acp70A.
Encodes a 36-amino-acid peptide that is synthesized in the accessory gland and is transferred to the female. The peptide contains a high concentration of basic amino acids, tryptophan and hydroxyproline as well as an unique residue of unknown nature that is encoded by a leucine codon.
Once transfered to the female Acp70A represses female sexual receptivity and stimulates oviposition.
Biochemical analysis and molecular regulation studies of the male accessory gland secretions of Acp70A demonstrate that Acp70A gene product inhibits remating and enhances the ovulation of virgin females. Acp70A gene product has no effect on virgins of phylogenetically related species.