FB2020_04, released Aug 18, 2020

Gene: Dmel\Ras85D

Open Close
General Information
Symbol
Dmel\Ras85D
Species
D. melanogaster
Name
Ras oncogene at 85D
Annotation Symbol
CG9375
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003205
Gene Model Status
Current
Stock Availability
291 publicly available
Gene Snapshot
Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

Ras, Ras1, Dras1, RasV12, dRas

Key Links
Genomic Location
Cytogenetic map
85D19-85D19
Sequence location
3R:9,510,561..9,513,067 [-]
Recombination map

3-48

RefSeq locus
NT_033777 REGION:9510561..9513067
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (74 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
GTPase activity
inferred from direct assay
(Gafuik and Steller, 2011)
protein binding
inferred from physical interaction with FLYBASE:Rgl; FB:FBgn0026376
(Mirey et al., 2003)
inferred from physical interaction with FLYBASE:spri; FB:FBgn0085443
(Jekely et al., 2005)
protein serine/threonine kinase activator activity
inferred from direct assay
(Douziech et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
GDP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (67 terms)
Terms Based on Experimental Evidence (67 terms)
CV Term
Evidence
References
activation of MAPKKK activity
inferred from direct assay
(Douziech et al., 2006)
border follicle cell migration
inferred from mutant phenotype
(Duchek and Rorth, 2001)
cell fate determination
inferred from mutant phenotype
(Gafuik and Steller, 2011)
cellular response to starvation
inferred from mutant phenotype
(Hou et al., 2008)
chorion-containing eggshell pattern formation
inferred from mutant phenotype
(James et al., 2002, Schnorr et al., 2001)
compound eye development
inferred from mutant phenotype
(Sung et al., 2010, Halfar et al., 2001)
defense response to virus
inferred from mutant phenotype
(Xu et al., 2013)
determination of adult lifespan
inferred from mutant phenotype
(Slack et al., 2015)
dorsal closure
inferred from mutant phenotype
(assigned by UniProt )
(Kushnir et al., 2017)
NOT dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
dorsal closure, spreading of leading edge cells
inferred from mutant phenotype
(assigned by UniProt )
(Kushnir et al., 2017)
epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Molnar and de Celis, 2013, Cabernard and Affolter, 2005, Duchek and Rorth, 2001, Yang and Baker, 2001, Diaz-Benjumea and Hafen, 1994)
inferred from genetic interaction with FLYBASE:grk; FB:FBgn0001137
(Schnorr and Berg, 1996)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Schnorr and Berg, 1996)
epithelial cell migration, open tracheal system
inferred from genetic interaction with FLYBASE:btl; FB:FBgn0285896
(Reichman-Fried et al., 1994)
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
establishment or maintenance of apical/basal cell polarity
inferred from mutant phenotype
(Poulton and Deng, 2006)
eye-antennal disc morphogenesis
inferred from mutant phenotype
(Brown et al., 2006)
fibroblast growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:stumps; FB:FBgn0020299
(Imam et al., 1999)
inferred from genetic interaction with FLYBASE:htl; FB:FBgn0010389
(Schulz and Gajewski, 1999, Michelson et al., 1998, Michelson et al., 1998, Gisselbrecht et al., 1996)
inferred from mutant phenotype
(Ukken et al., 2014, Cabernard and Affolter, 2005, Ohshiro et al., 2002, Michelson et al., 1998)
inferred from direct assay
(Michelson et al., 1998)
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Vincent et al., 1998)
gastrulation
inferred from mutant phenotype
(Li et al., 2003)
hemocyte migration
inferred from mutant phenotype
(Cho et al., 2002)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006, Pallavi and Shashidhara, 2003)
imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Gafuik and Steller, 2011)
imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Hahn et al., 2013, Molnar and de Celis, 2013, Roch et al., 2002)
instar larval development
inferred from mutant phenotype
(Caldwell et al., 2005)
intestinal stem cell homeostasis
inferred from mutant phenotype
(Bond and Foley, 2012)
leg disc proximal/distal pattern formation
inferred from expression pattern
(Galindo et al., 2005)
lymph gland crystal cell differentiation
inferred from mutant phenotype
(Dragojlovic-Munther and Martinez-Agosto, 2013)
lymph gland plasmatocyte differentiation
inferred from mutant phenotype
(Dragojlovic-Munther and Martinez-Agosto, 2013)
Malpighian tubule development
inferred from mutant phenotype
(Zeng et al., 2010)
MAPK cascade
inferred from mutant phenotype
(assigned by UniProt )
(O'Neill et al., 1994)
mesodermal cell fate commitment
inferred from genetic interaction with FLYBASE:htl; FB:FBgn0010389
(Michelson et al., 1998)
inferred from mutant phenotype
(Michelson et al., 1998)
metamorphosis
inferred from mutant phenotype
(Rewitz et al., 2009)
myoblast fate specification
inferred from genetic interaction with FLYBASE:htl; FB:FBgn0010389
(Schulz and Gajewski, 1999)
negative regulation of apoptotic process
inferred from mutant phenotype
(Wu et al., 2009, Parker, 2006)
negative regulation of apoptotic signaling pathway
inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997
(Kurada and White, 1998)
inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706
(Kurada and White, 1998)
negative regulation of autophagy
inferred from mutant phenotype
(Mohseni et al., 2009)
negative regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Cordero et al., 2004)
negative regulation of gene expression
inferred from mutant phenotype
(assigned by UniProt )
(Kushnir et al., 2017)
negative regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
ommatidial rotation
inferred from mutant phenotype
(Gaengel and Mlodzik, 2003)
oocyte axis specification
inferred from mutant phenotype
(Poulton and Deng, 2006)
peripheral nervous system development
inferred from mutant phenotype
(Sepp and Auld, 2003)
photoreceptor cell development
inferred from genetic interaction with UniProtKB:P51023
(assigned by UniProt )
(O'Neill et al., 1994)
photoreceptor cell differentiation
inferred from mutant phenotype
(Yang and Baker, 2001)
photoreceptor cell fate determination
inferred from genetic interaction with FLYBASE:rho; FB:FBgn0004635
(Freeman, 1994)
photoreceptor cell morphogenesis
inferred from mutant phenotype
(Gafuik and Steller, 2011)
positive regulation of cell population proliferation
inferred from mutant phenotype
(Buchon et al., 2010, Jiang and Edgar, 2009, Uhlirova and Bohmann, 2006)
positive regulation of cell size
inferred from mutant phenotype
(Denton et al., 2012, Sims et al., 2009)
positive regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Tran et al., 2013, Ohshiro et al., 2002)
inferred from direct assay
(Douziech et al., 2006, Roy et al., 2002)
positive regulation of hemocyte proliferation
inferred from mutant phenotype
(Arefin et al., 2017)
inferred from genetic interaction with FLYBASE:l(2)gl; FB:FBgn0002121
(Arefin et al., 2017)
inferred from genetic interaction with FLYBASE:scrib; FB:FBgn0263289
(Arefin et al., 2017)
positive regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Kim et al., 2006)
positive regulation of TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013)
R7 cell fate commitment
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Raabe et al., 1996, Fortini et al., 1992, Simon et al., 1991)
inferred from mutant phenotype
(Karim et al., 1996)
inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382, FLYBASE:sev; FB:FBgn0003366
(Allard et al., 1996)
Ras protein signal transduction
inferred from mutant phenotype
(Ashton-Beaucage et al., 2014)
inferred from high throughput genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Ashton-Beaucage et al., 2014)
regulation of apoptotic process
inferred from mutant phenotype
(Gafuik and Steller, 2011)
regulation of cell size
inferred from mutant phenotype
(Wu et al., 2009)
regulation of growth
inferred from mutant phenotype
(Brumby and Richardson, 2003)
inferred from genetic interaction with FLYBASE:scrib; FB:FBgn0263289
(Brumby and Richardson, 2003)
regulation of multicellular organism growth
inferred from mutant phenotype
(Caldwell et al., 2005)
sevenless signaling pathway
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Raabe et al., 1996, Fortini et al., 1992, Simon et al., 1991)
inferred from mutant phenotype
(Karim et al., 1996, Kauffmann et al., 1996)
inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382, FLYBASE:sev; FB:FBgn0003366
(Allard et al., 1996)
stem cell differentiation
inferred from mutant phenotype
(Zeng et al., 2010)
stem cell fate commitment
inferred from mutant phenotype
(Figeac et al., 2010)
stem cell proliferation
inferred from mutant phenotype
(Zeng et al., 2010)
terminal branching, open tracheal system
inferred from mutant phenotype
(Ukken et al., 2014)
terminal region determination
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
(Ambrosio et al., 1989)
torso signaling pathway
inferred from genetic interaction with FLYBASE:14-3-3ζ; FB:FBgn0004907
(Li et al., 1997)
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
(Doyle and Bishop, 1993, Ambrosio et al., 1989)
inferred from mutant phenotype
(Mishra et al., 2005, Hou et al., 1995, Lu et al., 1993)
trachea development
inferred from mutant phenotype
(Mortimer and Moberg, 2009)
tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Tran et al., 2013, Ragab et al., 2011, Sims et al., 2009)
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Bruckner et al., 2004, Cho et al., 2002)
wing disc morphogenesis
inferred from mutant phenotype
(Pallavi and Shashidhara, 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
epidermal growth factor receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002784442
(assigned by GO_Central )
(Gaudet et al., 2011)
Ras protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001529867
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
membrane
inferred from direct assay
(assigned by UniProt )
(Day et al., 2008)
plasma membrane
inferred from direct assay
(Day et al., 2008, Ezer et al., 1994)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Ras family. (P08646)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAS GTPASES -
The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).
Pathway (FlyBase)
Torso Signaling Pathway Core Components -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
Sevenless Signaling Pathway Core Components -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
EGFR Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR Core Components -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells (PubMed:11290305). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758). ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
(UniProt, P08646)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ras1: Ras proto-oncogene sequence
Codes for a polypeptide of 21.6 kilodaltons; residues 1-121 and 137-64 exhibit 75% homology with vertebrate H-ras protein.
Summary (Interactive Fly)

ras homolog - establishes follicular cell fate during oogenesis, functions in Torso signal transduction, functions downstream EGF-R in the establishment of ventral ectoderm fate, functions downstream of Breathless in tracheal and midline glia migration, functions downstream of FGF receptor in muscle precursors and in the central nervous system, functions downstream of the EGF-R and Sevenless in differentiation in photoreceptors

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ras85D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ras85D-RA
FBtr0082122
NM_057351
1958
189
Additional Transcript Data and Comments
Reported size (kB)

2.0, 1.3 (northern blot)

(Kimchie et al., 1989)

1.3 (northern blot)

(Segal and Shilo, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ras85D-PA
FBpp0081600
21.6
189
8.01
NP_476699
AAF54388
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ras85D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
membrane
inferred from direct assay
(assigned by UniProt )
(Day et al., 2008)
plasma membrane
inferred from direct assay
(Day et al., 2008, Ezer et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ras85D in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 64 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 67 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ras85D
Transgenic constructs containing regulatory region of Ras85D
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4elav-C155
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4sca.PU
lethal, with Scer\GAL4sli.PS
lethal | embryonic stage | germline clone | maternal effect | recessive
lethal | heat sensitive, with Scer\GAL4Bx-MS1096
lethal | heat sensitive, with Scer\GAL4dpp.blk1
lethal | maternal effect | recessive
lethal | recessive
lethal | temperature conditional
lethal - all die before end of embryonic stage | maternal effect
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of larval stage, with Scer\GAL4ap.PU
lethal - all die before end of larval stage | recessive
lethal - all die before end of larval stage | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
lethal - all die before end of P-stage, with Scer\GAL4Hml.Δ
lethal - all die before end of P-stage | somatic clone, with Scer\GAL4Act.PU
lethal - all die before end of P-stage | temperature conditional
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL4amn-X8
lethal - all die before end of pupal stage, with Scer\GAL4ap-md544
lethal - all die before end of pupal stage, with Scer\GAL4Bx-MS1096
lethal - all die before end of pupal stage, with Scer\GAL4en-e16E
lethal - all die before end of pupal stage, with Scer\GAL4GMR.PU
lethal - all die before end of pupal stage, with Scer\GAL4MD-638
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage | conditional, with Scer\GAL4Cg.PA
lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4Ras64B.PW
lethal - all die before end of pupal stage | somatic clone, with Scer\GAL4Act.PU
lethal - all die during embryonic stage, with Scer\GAL4ptc.PU
lethal - all die during pupal stage, with Scer\GAL4Bx-MS1096
lethal - all die during pupal stage, with Scer\GAL4GMR.PF
partially lethal
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4amn-c651
partially lethal - majority die, with Scer\GAL4ey.PU
partially lethal - majority die, with Scer\GAL4sev.EP
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Cg.PA
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
viable | somatic clone, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
viable | temperature conditional, with Scer\GAL4Bx-MS1096, Scer\GAL80ts.αTub84B
Sterility
Allele
female semi-sterile
female sterile
female sterile | recessive
Other Phenotypes
Allele
cell death defective | somatic clone, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
cell migration defective | adult stage, with Scer\GAL4byn-Gal4
cell migration defective | adult stage | progressive, with Scer\GAL4byn-Gal4
cell migration defective | larval stage, with Scer\GAL4dpp.blk1
cell number defective | adult stage, with Scer\GAL4NP0001
cell polarity defective
cell polarity defective, with Scer\GAL4E(spl)mδ-HLH.0.5
cell polarity defective, with Scer\GAL4hs.2sev
cell polarity defective | cell autonomous | somatic clone
cell polarity defective | cell non-autonomous | somatic clone
cell polarity defective | conditional | somatic clone, with Scer\GAL4FRT.Act5C, Scer\GAL80αTub84B.PL
cell size defective, with Scer\GAL4amn-c651
decreased cell death
decreased cell death | embryonic stage, with Scer\GAL4en-e16E
decreased cell death | heat sensitive, with Scer\GAL4hs.PB
decreased cell death | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
decreased cell death | pupal stage, with Scer\GAL4ey.PU
decreased cell death | somatic clone | wandering third instar larval stage, with Scer\GAL4Act5C.PI
decreased cell number, with Scer\GAL4C587
decreased cell number | adult stage
decreased cell number | adult stage, with Scer\GAL4NP5130
decreased cell number | adult stage | somatic clone
decreased cell number | larval stage | recessive
decreased cell number | larval stage | somatic clone, with Scer\GAL4Act5C.PP
decreased cell number | prepupal stage P1, with Scer\GAL4NP7397
decreased cell size
decreased cell size | somatic clone
decreased cell size | somatic clone, with Scer\GAL4Act5C.PP
decreased occurrence of cell division | adult stage, with Scer\GAL4byn-Gal4
decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4NP5130
decreased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4NP5130
decreased occurrence of cell division | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
developmental rate defective, with Scer\GAL4phm.PO
developmental rate defective | larval stage, with Scer\GAL4amn-c651
developmental rate defective | larval stage, with Scer\GAL4amn-X8
developmental rate defective | larval stage, with Scer\GAL4phm.PO
developmental rate defective | P-stage, with Scer\GAL4GMR.PF
developmental rate defective | second instar larval stage, with Scer\GAL4amn-c651
eclosion rhythm defective, with Scer\GAL4phm.PO
endocytosis defective, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
endomitotic cell cycle defective | adult stage, with Scer\GAL4NP0001
hyperplasia, with Scer\GAL4dpp.blk1
hyperplasia | adult stage, with Scer\GAL4ey.PU
hyperplasia | conditional, with Scer\GAL4nub.PK
hyperplasia | conditional | somatic clone, with Scer\GAL4FRT.Act5C, Scer\GAL80αTub84B.PL
hyperplasia | larval stage, with Scer\GAL4dpp.blk1
hyperplasia | somatic clone, with Scer\GAL4Act.PU
hyperplasia | somatic clone, with Scer\GAL4FRT.Act5C
hyperplasia | third instar larval stage | temperature conditional
immune response defective | adult stage, with Scer\GAL4NP5130
immune response defective | adult stage | somatic clone
increased cell death
increased cell death | adult stage, with Scer\GAL4byn-Gal4
increased cell death | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell death | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
increased cell death | embryonic stage, with Scer\GAL4en-e16E
increased cell death | somatic clone
increased cell death | third instar larval stage
increased cell growth, with Scer\GAL4FRT.Act5C
increased cell number, with Scer\GAL4ey.PH
increased cell number, with Scer\GAL4Hml.PG
increased cell number | adult stage
increased cell number | adult stage, with Scer\GAL4esg.PU
increased cell number | adult stage | somatic clone, with Scer\GAL4repo.PU
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased cell number | larval stage, with Scer\GAL4He.PZ
increased cell number | larval stage, with Scer\GAL4Hml.Δ
increased cell number | pupal stage, with Scer\GAL4GMR.PF
increased cell number | somatic clone, with Scer\GAL4αTub84B.PL
increased cell number | third instar larval stage, with Scer\GAL4NP7397
increased cell size, with Scer\GAL4tin.CΔ4
increased cell size | embryonic stage, with Scer\GAL4en-e16E
increased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased occurrence of cell division | adult stage, with Scer\GAL4byn-Gal4
increased occurrence of cell division | adult stage, with Scer\GAL4dpp.blk1
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
increased occurrence of cell division | adult stage, with Scer\GAL4NP7397
increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4FRT.Act5C
increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4NP7397
increased occurrence of cell division | larval stage, with Scer\GAL4ey.PU
increased occurrence of cell division | pupal stage, with Scer\GAL4ey.PU
increased occurrence of cell division | somatic clone | third instar larval stage, with Scer\GAL4FRT.Act5C
increased occurrence of cell division | third instar larval stage
large body | adult stage, with Scer\GAL4amn-c651
large body | pupal stage, with Scer\GAL4amn-c651
large body | pupal stage, with Scer\GAL4amn-X8
learning defective, with Scer\GAL4c739
learning defective, with Scer\GAL4c747
locomotor behavior defective | larval stage | conditional, with Scer\GAL4Hml.Δ
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
long lived | RU486 conditional, with Scer\GAL4Switch1.106
majority die during pharate adult stage, with Scer\GAL4sev.EP
majority die during P-stage, with Scer\GAL45015
melanotic mass phenotype, with Scer\GAL4Bx-MS1096
mitotic cell cycle defective | larval stage, with Scer\GAL4GMR.PF
mitotic cell cycle defective | maternal effect
mitotic cell cycle defective | somatic clone
mitotic cell cycle defective | third instar larval stage, with Scer\GAL4Bx-MS1096
neoplasia | larval stage | somatic clone, with Scer\GAL4Act5C.PI
neoplasia | third instar larval stage, with Scer\GAL4repo.PU
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4FRT.Act5C
neuroanatomy defective, with Scer\GAL4futsch-C380
neuroanatomy defective, with Scer\GAL4sca.PC
neuroanatomy defective | adult stage | somatic clone, with Scer\GAL4repo.PU
neuroanatomy defective | embryonic stage, with Scer\GAL4repo
neuroanatomy defective | larval stage, with Scer\GAL4unspecified
neuroanatomy defective | somatic clone | third instar larval stage, with Scer\GAL4C855a
neuroanatomy defective | third instar larval stage, with Scer\GAL4C855a
neuroanatomy defective | third instar larval stage, with Scer\GAL4Gli-rL82
neuroanatomy defective | third instar larval stage, with Scer\GAL4GMR.PF
neuroanatomy defective | third instar larval stage, with Scer\GAL4repo.PU
neurophysiology defective
neurophysiology defective | larval stage, with Scer\GAL4unspecified
short lived | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
short lived | RU486 conditional, with Scer\GAL4da.Switch.PT
size defective, with Scer\GAL4NP0001
size defective | adult stage, with Scer\GAL4Bx-MS1096
size defective | adult stage, with Scer\GAL4dpp.blk1
size defective | adult stage | temperature conditional
size defective | larval stage, with Scer\GAL4Bx-MS1096
size defective | larval stage, with Scer\GAL4dpp.PU
size defective | somatic clone | wandering third instar larval stage, with Scer\GAL4Act.PU
size defective | third instar larval stage
size defective | third instar larval stage, with Scer\GAL4ap-md544
size defective | third instar larval stage, with Scer\GAL4Hml.Δ
small body
small body | adult stage, with Scer\GAL4amn-c651
small body | adult stage, with Scer\GAL4Ras64B.PW
small body | larval stage, with Scer\GAL4amn-c651
small body | larval stage, with Scer\GAL4amn-X8
small body | pupal stage, with Scer\GAL4amn-c651
small body | pupal stage, with Scer\GAL4amn-X8
small body | pupal stage, with Scer\GAL4phm.PO
some die during embryonic stage | maternal effect
some die during embryonic stage | recessive
some die during larval stage, with Scer\GAL4amn-c651
some die during larval stage | recessive
some die during larval stage | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
some die during P-stage | somatic clone, with Scer\GAL4Act.PU
some die during pupal stage
some die during pupal stage, with Scer\GAL4amn-X8
some die during pupal stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4MD-638
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | conditional, with Scer\GAL4Cg.PA
some die during pupal stage | heat sensitive, with Scer\GAL4Ras64B.PW
terminal phenotype | germline clone | maternal effect
tumorigenic, with Scer\GAL4ap.PU
tumorigenic | adult stage | temperature conditional
tumorigenic | larval stage, with Scer\GAL4dpp.blk1
tumorigenic | larval stage | somatic clone, with Scer\GAL4Act5C.PI
tumorigenic | somatic clone, with Scer\GAL4Act5C.PI
tumorigenic | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
tumorigenic | somatic clone | third instar larval stage, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
tumorigenic | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
tumorigenic | somatic clone | third instar larval stage, with Scer\GAL4FRT.Act5C
visible
visible, with Scer\GAL4bi.PU
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.3KK
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en.PU
visible, with Scer\GAL4ey.3.5.Exel
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4hs.2sev
visible, with Scer\GAL4sca.PU
visible, with Scer\GAL4sca-C253
visible, with Scer\GAL4sev.EP
visible | adult stage, with Scer\GAL4Bx-MS1096
visible | dominant
visible | heat sensitive
visible | pupal stage, with Scer\GAL4MD-638
visible | pupal stage P5, with Scer\GAL4GMR.PF
visible | recessive
visible | recessive | somatic clone
visible | somatic clone, with Ras85DD38E
visible | somatic clone, with Ras85Dx7b
visible | somatic clone, with Scer\GAL4Act5C.PP
wild-type
Phenotype manifest in
Allele
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 1 ventral monoscolopidial chordotonal organ vch1
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 2 ventral monoscolopidial chordotonal organ vch1
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 3 ventral monoscolopidial chordotonal organ vch1
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 4 ventral monoscolopidial chordotonal organ vch1
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 5 ventral monoscolopidial chordotonal organ vch1
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 6 ventral monoscolopidial chordotonal organ vch1
abdominal 7 lateral pentascolopidial chordotonal organ lch5
abdominal 7 ventral monoscolopidial chordotonal organ vch1
abdominal dorsal adult muscle precursor cell, with Scer\GAL4how-24B
abdominal dorso-lateral adult muscle precursor cell, with Scer\GAL4how-24B
abdominal lateral adult muscle precursor cell, with Scer\GAL4how-24B
abdominal neuron | pupal stage P6, with Scer\GAL4GMR.PF
abdominal segment 1
abdominal segment 2
abdominal segment 3
abdominal segment 4
abdominal segment 5
abdominal segment 6
abdominal segment 7
abdominal segment 8
abdominal segment 9
abdominal segment 10
abdominal segment 11
adult abdomen, with Scer\GAL4byn-Gal4
adult brain | somatic clone, with Scer\GAL4repo.PU
adult gut, with Scer\GAL4NP0001
adult gut, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
adult head | somatic clone
adult heart, with Scer\GAL4tin.CΔ4
adult heart muscle, with Scer\GAL4tin.CΔ4
adult hindgut, with Scer\GAL4byn-Gal4
adult Malpighian tubule | conditional | somatic clone, with Scer\GAL4FRT.Act5C, Scer\GAL80αTub84B.PL
adult Malpighian tubule | somatic clone
adult midgut, with Scer\GAL4NP5130
adult midgut | somatic clone
adult midgut | somatic clone, with Scer\GAL4NP5130
adult midgut | somatic clone, with Scer\GAL4Tub.PU
adult midgut enterocyte, with Scer\GAL4NP0001
adult midgut epithelium, with Scer\GAL4esg.PU
adult midgut progenitor cell | larval stage
adult midgut progenitor cell | prepupal stage P1, with Scer\GAL4NP7397
adult midgut progenitor cell | third instar larval stage, with Scer\GAL4NP7397
adult optic lobe | adult stage | somatic clone, with Scer\GAL4repo.PU
adult posterior midgut epithelium | somatic clone | somatic clone, with Scer\GAL4NP7397
adult pyloric epithelium, with Scer\GAL4byn-Gal4
amnioserosa, with Scer\GAL4Orct2-cald-GAL4
anterior crossvein, with Scer\GAL4dpp.blk1
arista, with Scer\GAL4dpp.blk1
border follicle cell
border follicle cell, with Scer\GAL4c306
border follicle cell, with Scer\GAL4hs.PB
border follicle cell, with Scer\GAL4slbo.2.6
bouton | supernumerary, with Scer\GAL4futsch-C380
bouton | supernumerary, with Scer\GAL4sca.PC
bract
bract | ectopic | somatic clone, with Scer\GAL4Act.PU
bract | somatic clone
capitellum, with Scer\GAL4dpp.blk1
cardial cell, with Scer\GAL4tin.CΔ4
chaeta | ectopic, with Scer\GAL4dpp.blk1
cone cell
cone cell | heat sensitive
cone cell | precursor
coxa | proximal, with Scer\GAL4dpp.blk1
cyst progenitor cell | male | somatic clone
denticle | ectopic, with Scer\GAL4en-e16E
denticle belt, with Scer\GAL469B
denticle belt, with Scer\GAL4arm.PS
denticle belt, with Scer\GAL4e22c
denticle row 5, with Scer\GAL4arm.PS
denticle row 6, with Scer\GAL4arm.PS
dMP2 neuron, with Scer\GAL4elav.PLu
dorsal acute muscle | precursor, with Scer\GAL4twi.PB
dorsal air sac primordium | somatic clone
dorsal air sac primordium | somatic clone, with Scer\GAL4αTub84B.PL
dorsal appendage
dorsal appendage (with Df(3R)by10)
dorsal appendage | maternal effect (with Ras85D05703)
dorsal appendage | maternal effect (with Ras85De1B)
dorsal appendage | somatic clone
dorsal mesothoracic disc & peripodial epithelium | somatic clone, with Scer\GAL4αTub84B.PL
dorsal oblique muscle | ectopic | precursor, with Scer\GAL4twi.PB
egg
egg chamber
egg chorion
embryo
embryo | dorsal closure stage, with Scer\GAL4en.PU
embryo | gastrula stage
embryo | germline clone | maternal effect
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4en-e16E
embryonic/first instar larval cuticle | dorsal
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1
embryonic/larval brain | somatic clone | third instar larval stage, with Scer\GAL4C855a
embryonic/larval brain | third instar larval stage, with Scer\GAL4C855a
embryonic/larval brain | third instar larval stage, with Scer\GAL4repo.PU
embryonic/larval ganglionic branch 1 | embryonic stage, with Scer\GAL4bs-23.26
embryonic/larval ganglionic branch, with Scer\GAL4bs-23.26
embryonic/larval hemocyte | larval stage | supernumerary, with Scer\GAL4Hml.Δ
embryonic/larval hemocyte | supernumerary, with Scer\GAL4Cg.PA
embryonic/larval hemocyte | supernumerary, with Scer\GAL4stop.Hml
embryonic/larval hemocyte | supernumerary | heat sensitive, with Scer\GAL4Cg.PA
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval lymph gland, with Scer\GAL4HCH.Hand, Scer\GAL4Hml.Δ
embryonic/larval midgut, with Scer\GAL4NP0001
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4unspecified
embryonic/larval oenocyte | supernumerary, with Scer\GAL4en-e16E
embryonic/larval peripheral nervous system | third instar larval stage, with Scer\GAL4Gli-rL82
embryonic/larval salivary gland, with Scer\GAL4Bx-MS1096
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic/larval somatic muscle, with Scer\GAL4unspecified
embryonic/larval trachea, with Scer\GAL4btl.PS
embryonic/larval tracheal system, with Scer\GAL4btl.PS
embryonic abdominal segment 8
embryonic abdominal segment 8 | germline clone
embryonic cardioblast, with Scer\GAL4Mef2.PR
embryonic epidermis, with Scer\GAL469B
embryonic epidermis, with Scer\GAL4e22c
embryonic head | maternal effect
embryonic hemocyte, with Scer\GAL4srp.Hemo
embryonic leading edge cell, with Scer\GAL4en.PU
embryonic midgut constriction 1, with Scer\GAL4how-24B
embryonic segment, with Scer\GAL4en-e16E
enteroblast of posterior adult midgut epithelium, with Scer\GAL4NP5130
enterocyte
enterocyte, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
enterocyte, with Scer\GAL4NP7397
enterocyte | somatic clone, with Scer\GAL4unspecified
eye
eye, with Scer\GAL4dpp.blk1
eye, with Scer\GAL4ey.3.5.Exel
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye, with Scer\GAL4sev.EP
eye | somatic clone
eye | somatic clone, with Ras85DD38E
eye | somatic clone, with Ras85Dx7b
eye | somatic clone, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
eye | temperature conditional
eye-antennal disc | larval stage, with Scer\GAL4dpp.PU
eye-antennal disc | larval stage | somatic clone, with Scer\GAL4Act5C.PI
eye-antennal disc | somatic clone, with Scer\GAL4Act5C.PI
eye-antennal disc | somatic clone, with Scer\GAL4Act.PU
eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4FRT.Act5C
eye-antennal disc | third instar larval stage | temperature conditional
eye disc, with Scer\GAL4Act5C.PP
eye disc, with Scer\GAL4GMR.PF
eye disc & photoreceptor cell, with Scer\GAL4Act5C.PP
eye disc | heat sensitive
eye disc | heat sensitive, with Scer\GAL4hs.PB
eye disc | larval stage, with Scer\GAL4ey.PU
eye disc | larval stage, with Scer\GAL4GMR.PF
eye disc | pupal stage, with Scer\GAL4ey.PU
eye disc | somatic clone
eye disc | somatic clone, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
eye disc | somatic clone, with Scer\GAL4Act5C.PP
eye disc | somatic clone, with Scer\GAL4Act.PU
eye disc | somatic clone | third instar larval stage
eye disc | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
eye disc | third instar larval stage
eye photoreceptor cell
eye photoreceptor cell (with Ras85D2F4)
eye photoreceptor cell (with Ras85De2F)
eye photoreceptor cell | adult stage | supernumerary
eye photoreceptor cell | ectopic
eye photoreceptor cell | ectopic, with Scer\GAL4da.G32
fascicle | embryonic stage, with Scer\GAL4repo
female terminalia
filzkorper
filzkorper | embryonic stage | maternal effect
filzkorper | germline clone
follicle cell | somatic clone
fusion competent cell, with Scer\GAL4twi.PB
gastric caecum, with Scer\GAL4NP0001
gastric caecum | somatic clone, with Scer\GAL4Act5C.PP
germarium, with Scer\GAL4unspecified
germline stem cell, with Scer\GAL4C587
germline stem cell | supernumerary, with Scer\GAL4C587
glial cell, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
glial cell & antennal disc, with Scer\GAL4hs.PB
glial cell | adult stage | somatic clone | supernumerary, with Scer\GAL4repo.PU
glial cell | supernumerary | third instar larval stage, with Scer\GAL4repo.PU
gonopod thorn bristle | ectopic, with Scer\GAL4dpp.blk1
haltere pedicel, with Scer\GAL4dpp.blk1
head
head | pharate adult stage | temperature conditional
hemocyte, with Scer\GAL4He.PZ
hemocyte, with Scer\GAL4Hml.PG
imaginal disc | somatic clone
imaginal disc | somatic clone, with Scer\GAL4Act5C.PP
interface glial cell, with Scer\GAL4S007708-Jan136
interommatidial bristle, with Scer\GAL4hs.2sev
intestinal stem cell
intestinal stem cell, with Scer\GAL4NP0001
intestinal stem cell, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
intestinal stem cell, with Scer\GAL4NP7397
intestinal stem cell | adult stage, with Scer\GAL4NP5130
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4NP5130
intestinal stem cell | somatic clone
lamellocyte | supernumerary, with Scer\GAL4Bx-MS1096
lamina | third instar larval stage
larval neuroblast | ectopic | somatic clone | third instar larval stage, with Scer\GAL4C855a
larval neuroblast | ectopic | third instar larval stage, with Scer\GAL4C855a
larval optic lobe & glial cell | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PP
macrochaeta
macrochaeta | ectopic, with Scer\GAL4sca.PU
main body follicle cell | cell autonomous | somatic clone
male terminalia
male terminalia, with Scer\GAL4- :
male terminalia, with Scer\GAL4Pvf1-LP23
Malpighian tubule | pupal stage P5, with Scer\GAL4GMR.PF
Malpighian tubule | pupal stage P6, with Scer\GAL4GMR.PF
medulla cortex & glial cell | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PP
melanotic mass, with Scer\GAL4He.PZ
mesoderm, with Scer\GAL4twi.PG
mesothoracic tarsal segment 1 & bract
mesothoracic tarsal segment 1 & bract | ectopic
mesothoracic tergum, with Scer\GAL4Ubx-lac1-Gal4
mesothoracic tergum & macrochaeta | ectopic, with Scer\GAL4sca-C253
mesothoracic tergum & macrochaeta | supernumerary, with Scer\GAL4sca-C253
mesothoracic tergum | ectopic | larval stage | somatic clone, with Scer\GAL4αTub84B.PL
mesothoracic tibial bract | ectopic
midgut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
midline glial cell
midline glial cell | ectopic, with Scer\GAL4sli.PS
mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
morphogenetic furrow, with Scer\GAL4dpp.blk1
morphogenetic furrow | ectopic, with Scer\GAL4dpp.blk1
morphogenetic furrow | somatic clone, with Scer\GAL4GMR.PF
motor neuron | embryonic stage, with Scer\GAL4repo
muscle founder cell & visceral muscle primordium | ectopic, with Scer\GAL4twi.2PE
muscle founder cell | supernumerary, with Scer\GAL4twi.PB
myofilament, with Scer\GAL4tin.CΔ4
nurse cell
ommatidial precursor cluster | somatic clone
ommatidial precursor cluster | somatic clone, with Scer\GAL4GMR.PF
ommatidium
ommatidium, with Scer\GAL4E(spl)mδ-HLH.0.5
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4hs.2sev
ommatidium | somatic clone | third instar larval stage
oocyte
oocyte | cell non-autonomous | somatic clone
optic cartridge | third instar larval stage, with Scer\GAL4GMR.PF
ovary
pCC neuron, with Scer\GAL4elav.PLu
pericardial cell | ectopic | precursor, with Scer\GAL4twi.PB
pericardial cell primordium | embryonic stage 10
peripheral glial cell | embryonic stage, with Scer\GAL4repo
photoreceptor cell
photoreceptor cell (with Ras85D2F4)
photoreceptor cell (with Ras85De2F)
photoreceptor cell & axon & eye disc, with Scer\GAL4bi-omb-Gal4
photoreceptor cell | ectopic, with Scer\GAL4Act5C.PP
photoreceptor cell | ectopic, with Scer\GAL4GMR.PF
photoreceptor cell | P-stage | ectopic, with Scer\GAL4GMR.PF
photoreceptor cell | supernumerary, with Scer\GAL4GMR.PF
photoreceptor cell R1
photoreceptor cell R2
photoreceptor cell R2 | somatic clone
photoreceptor cell R3
photoreceptor cell R3 | somatic clone
photoreceptor cell R4
photoreceptor cell R4 | somatic clone
photoreceptor cell R5
photoreceptor cell R5 | somatic clone
photoreceptor cell R6
photoreceptor cell R7
photoreceptor cell R7 | ectopic
photoreceptor cell R7 | supernumerary
photoreceptor cell R8 | somatic clone | supernumerary
pigment cell
posterior crossvein
presumptive embryonic/larval peripheral nervous system, with Scer\GAL4repo
primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4Hml.Δ
primordial germ cell | ectopic | maternal effect
prothoracic gland, with Scer\GAL4amn-c651
prothoracic gland, with Scer\GAL4phm.PO
pupa | pupal stage P5, with Scer\GAL4GMR.PF
rhabdomere | supernumerary, with Scer\GAL4hs.2sev
salivary gland | pupal stage P6, with Scer\GAL4GMR.PF
salivary gland common duct primordium | maternal effect
secondary pigment cell | heat sensitive
secondary pigment cell | precursor
sensillum trichodeum | supernumerary, with Scer\GAL4dpp.blk1
sensory mother cell, with Scer\GAL4sca-C253
sensory neuron & axon & embryo, with Scer\GAL4repo
spectrosome | supernumerary, with Scer\GAL4unspecified
subretinal glial cell & eye disc, with Scer\GAL4bi-omb-Gal4
subretinal glial cell & larval optic stalk, with Scer\GAL4bi-omb-Gal4
tarsal segment, with Scer\GAL4dpp.blk1
tergite
tertiary pigment cell | heat sensitive
tertiary pigment cell | precursor
third segment of antenna, with Scer\GAL4dpp.blk1
tracheal branch primordium, with Scer\GAL4btl.PS
type I bouton
type I bouton | supernumerary, with Scer\GAL4futsch-C380
ventral acute muscle 2 | precursor
ventral nerve cord, with Scer\GAL4FRT.Act5C
ventral nerve cord | larval stage | somatic clone, with Scer\GAL4Act5C.PI
vesicle, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
vMP2 neuron, with Scer\GAL4elav.PLu
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4Ubx-lac1-Gal4
wing disc, with Scer\GAL4ap-md544
wing disc, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4dpp.blk1
wing disc, with Scer\GAL4Gug-AGiR
wing disc, with Scer\GAL4tsh-md621
wing disc, with Scer\GAL4Ubx-lac1-Gal4
wing disc | conditional, with Scer\GAL4nub.PK
wing disc | larval stage, with Scer\GAL4Bx-MS1096
wing disc | larval stage, with Scer\GAL4dpp.blk1
wing disc | larval stage, with Scer\GAL4dpp.PU
wing disc | somatic clone
wing disc | somatic clone | wandering third instar larval stage, with Scer\GAL4Act.PU
wing disc | third instar larval stage, with Scer\GAL4ap.PU
wing disc | third instar larval stage, with Scer\GAL4Bx-MS1096
wing disc | wandering third instar larval stage, with Scer\GAL4Act5C.PI
wing disc anterior compartment | larval stage, with Scer\GAL4dpp.blk1
wing disc dorsal compartment | third instar larval stage, with Scer\GAL4ap-md544
wing disc posterior compartment, with Scer\GAL4en.PU
wing hair | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing margin, with Scer\GAL4vg.PU
wing margin | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing vein
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4dpp.3KK
wing vein, with Scer\GAL4dpp.blk1
wing vein, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4MD-638
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4en.PU
wing vein | ectopic, with Scer\GAL4MD-638
wing vein | ectopic | somatic clone, with Scer\GAL4Act5C.PP
wing vein | ectopic | supernumerary, with Scer\GAL4Bx-MS1096
wing vein | heat sensitive
wing vein | somatic clone
wing vein | somatic clone, with Scer\GAL4Act5C.PP
wing vein | supernumerary
wing vein L2, with Scer\GAL4salm-459.2
wing vein L3, with Scer\GAL4dpp.blk1
wing vein L3, with Scer\GAL4salm-459.2
wing vein L4
wing vein L4, with Scer\GAL4bi.PU
wing vein L4, with Scer\GAL4salm-459.2
wing vein L5
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HRAS
13 of 15
Yes
Yes
1  
Hsap\KRAS
12 of 15
No
Yes
Hsap\NRAS
10 of 15
No
Yes
Hsap\RRAS2
4 of 15
No
No
Hsap\ERAS
3 of 15
No
Yes
Hsap\RRAS
3 of 15
No
No
Hsap\MRAS
2 of 15
No
Yes
Hsap\RAP1A
2 of 15
No
No
3  
Hsap\RAP1B
2 of 15
No
No
Hsap\RALA
1 of 15
No
No
1  
Hsap\RALB
1 of 15
No
No
1  
Hsap\RAP2A
1 of 15
No
No
Hsap\RAP2B
1 of 15
No
No
Hsap\RAP2C
1 of 15
No
No
Hsap\RHEB
1 of 15
No
No
1  
Hsap\RHEBL1
1 of 15
No
No
Hsap\RIT1
1 of 15
No
No
Hsap\RIT2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hras
12 of 15
Yes
Yes
Mmus\Kras
12 of 15
Yes
Yes
Mmus\Nras
10 of 15
No
Yes
Mmus\Rras2
4 of 15
No
No
Mmus\Eras
3 of 15
No
Yes
Mmus\Rras
3 of 15
No
No
Mmus\Mras
2 of 15
No
Yes
Mmus\Rap1a
2 of 15
No
No
Mmus\Rap1b
2 of 15
No
No
Mmus\Rala
1 of 15
No
No
Mmus\Rap2a
1 of 15
No
No
Mmus\Rap2b
1 of 15
No
No
Mmus\Rap2c
1 of 15
No
No
Mmus\Rhebl1
1 of 15
No
No
Mmus\Rheb
1 of 15
No
No
Mmus\Rit1
1 of 15
No
No
Mmus\Rit2
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Hras
11 of 13
Yes
Yes
Rnor\Kras
11 of 13
Yes
Yes
Rnor\Nras
10 of 13
No
Yes
Rnor\Rras2
3 of 13
No
No
Rnor\Eras
2 of 13
No
Yes
Rnor\LOC367858
2 of 13
No
Yes
Rnor\Mras
2 of 13
No
Yes
Rnor\Rras
2 of 13
No
No
Rnor\LOC103690157
1 of 13
No
Yes
Rnor\Rala
1 of 13
No
No
Rnor\Ralb
1 of 13
No
No
Rnor\Rap1a
1 of 13
No
No
Rnor\Rap1b
1 of 13
No
No
Rnor\Rap2a
1 of 13
No
No
Rnor\Rap2b
1 of 13
No
No
Rnor\Rap2c
1 of 13
No
No
Rnor\Rhebl1
1 of 13
No
No
Rnor\Rheb
1 of 13
No
No
Rnor\Rit1
1 of 13
No
No
Rnor\Rit2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\hras
11 of 12
Yes
Yes
Xtro\kras
10 of 12
No
Yes
Xtro\LOC100485959
9 of 12
No
Yes
Xtro\nras
6 of 12
No
Yes
Xtro\rras
3 of 12
No
No
Xtro\mras
2 of 12
No
Yes
Xtro\ralb
2 of 12
No
Yes
Xtro\rap1b
2 of 12
No
No
Xtro\rala
1 of 12
No
No
Xtro\rap1a
1 of 12
No
No
Xtro\rap2a
1 of 12
No
No
Xtro\rap2b
1 of 12
No
No
Xtro\rap2c
1 of 12
No
No
Xtro\rhebl1
1 of 12
No
No
Xtro\rheb
1 of 12
No
No
Xtro\rit1
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\hrasa
12 of 15
Yes
Yes
Drer\hrasb
12 of 15
Yes
Yes
Drer\kras
12 of 15
Yes
Yes
Drer\zgc:55558
10 of 15
No
Yes
Drer\nras
8 of 15
No
Yes
Drer\rras2
4 of 15
No
No
Drer\rras
3 of 15
No
No
Drer\mras
2 of 15
No
Yes
Drer\rap1aa
2 of 15
No
No
Drer\rap1ab
2 of 15
No
No
Drer\rap1b
2 of 15
No
No
Drer\si:ch73-116o1.2
2 of 15
No
Yes
Drer\LOC100332969
1 of 15
No
No
Drer\ralaa
1 of 15
No
No
Drer\ralab
1 of 15
No
No
Drer\ralba
1 of 15
No
No
Drer\rap2ab
1 of 15
No
No
Drer\rap2b
1 of 15
No
No
Drer\rap2c
1 of 15
No
No
Drer\rheb
1 of 15
No
No
Drer\rhebl1
1 of 15
No
No
Drer\rit1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\let-60
15 of 15
Yes
Yes
Cele\ras-1
4 of 15
No
No
Cele\rap-1
2 of 15
No
No
Cele\ras-2
2 of 15
No
Yes
Cele\ral-1
1 of 15
No
No
Cele\rap-2
1 of 15
No
No
Cele\rap-3
1 of 15
No
No
Cele\rheb-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\GB2
1 of 9
Yes
No
Atha\RABA6a
1 of 9
Yes
Yes
Atha\RABB1a
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\RAS2
6 of 15
Yes
No
Scer\RAS1
5 of 15
No
No
Scer\RSR1
2 of 15
No
No
Scer\RHB1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ras1
6 of 12
Yes
No
Spom\rhb1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190HG8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009599
Drosophila simulans
Dsim\Ras85D
Drosophila sechellia
Dsec\GM26252
Drosophila erecta
Dere\GG17366
Drosophila yakuba
Dyak\GE24771
Drosophila ananassae
Dana\GF16057
Drosophila pseudoobscura pseudoobscura
Dpse\GA21740
Drosophila persimilis
Dper\GL22227
Drosophila willistoni
Dwil\GK13838
Drosophila virilis
Dvir\Ras1
Drosophila mojavensis
Dmoj\GI22599
Drosophila grimshawi
Dgri\GH19394
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D9J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015201
Glossina morsitans
Tsetse fly
Gmor\GMOY011137
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04013
Mayetiola destructor
Hessian fly
Mdes\Mdes001901
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012071
Anopheles darlingi
American malaria mosquito
Adar\ADAC008414
Anopheles gambiae
Malaria mosquito
Agam\AGAP002219
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006054
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GLY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\Bras1
Danaus plexippus
Monarch butterfly
Dple\DPOGS215072-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010545
Apis florea
Little honeybee
Aflo\2417181862
Apis mellifera
Western honey bee
Amel\LOC410812
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16916
Bombus terrestris
Buff-tailed bumblebee
Bter\15214845
Linepithema humile
Argentine ant
Lhum\LH17909
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b0a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005937
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07716
Tribolium castaneum
Red flour beetle
Tcas\TC001037
Pediculus humanus
Human body louse
Phum\PHUM380970
Rhodnius prolixus
Kissing bug
Rpro\RPRC008553
Cimex lectularius
Bed bug
Clec\CLEC011429
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000776
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07077
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14471
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07076
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GMK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009471
Strigamia maritima
European centipede
Smar\SMAR011511
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77725.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g07840
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_192739
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301818
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0UAU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rit1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mras
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026578gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adsda
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RalA
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kras
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023365
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021692
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021946
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001900
Gallus gallus
Domestic chicken
Ggal\TM2D3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026692
Gallus gallus
Domestic chicken
Ggal\RALA
Gallus gallus
Domestic chicken
Ggal\MRAS
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026924
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014647
Gallus gallus
Domestic chicken
Ggal\KRAS
Gallus gallus
Domestic chicken
Ggal\RRAS2
Gallus gallus
Domestic chicken
Ggal\H-RAS
Gallus gallus
Domestic chicken
Ggal\RALB
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ras64B
7 of 10
Rap1
4 of 10
Rala
3 of 10
Rap2l
3 of 10
Rheb
3 of 10
Ric
3 of 10
CG8500
2 of 10
CG13375
2 of 10
CG5160
1 of 10
CG8519
1 of 10
CG8641
1 of 10
CG14669
1 of 10
CG30158
1 of 10
κB-Ras
1 of 10
Rgk3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Allele
Disease
Evidence
References
Ras85DG12V.UAS
model of  cancer
CEA with RhoGEF2RE.UAS
(Khoo et al., 2013)
CEA with RokCAT.UAS
(Khoo et al., 2013)
CEA with sqhE20E21.UAS.cCa
(Khoo et al., 2013)
Ras85DV12.S35.UAS
model of  cardiomyopathy
CEA
(Yu et al., 2013)
Ras85DV12.UAS
model of  cancer
CEA with fmt1
(Ma et al., 2017)
CEA with PpVΔ1
(Ma et al., 2017)
CEA with l(2)gl4
(Ma et al., 2017, Ma et al., 2013, Pagliarini and Xu, 2003)
CEA with PpVGD7532
(Ma et al., 2017)
CEA
(Rives-Quinto et al., 2017, Chabu and Xu, 2014, Ma et al., 2013)
CEA with scrib673
(Katheder et al., 2017)
CEA with scrib1
(Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Külshammer et al., 2015, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)
CEA with dlg1GD4689
(Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Willecke et al., 2011)
CEA with scribj7B3
(Pagliarini and Xu, 2003)
CEA with dlg114
(Pagliarini and Xu, 2003)
CEA with baz4
(Pagliarini and Xu, 2003)
CEA with sdtXN
(Pagliarini and Xu, 2003)
CEA with Cdc421
(Pagliarini and Xu, 2003)
CEA with dorC107
(Chi et al., 2010)
CEA with dor8
(Chi et al., 2010)
CEA with dorD185
(Chi et al., 2010)
CEA with cardsRNA.UAS
(Chi et al., 2010)
CEA with Vps16AdsRNA.UAS.WIZ
(Chi et al., 2010)
CEA with upd1UAS.cUa
(Wu et al., 2010)
CEA with upd2UAS.cUa
(Wu et al., 2010)
CEA with upd1UAS.cUa, upd2UAS.cUa, upd3UAS.cUa
(Wu et al., 2010)
CEA with l(2)glunspecified
(Wu et al., 2010)
CEA with pnutGD1512
(Gerlach et al., 2018)
CEA with Hsap\S100A4wt.UAS
(Ismail et al., 2017)
model of  colorectal cancer
CEA
(Bangi et al., 2012)
model of  leukemia
CEA
(Arefin et al., 2017)
CEA with l(2)glKK100777
(Arefin et al., 2017)
CEA with scribKK101128
(Arefin et al., 2017)
model of  benign neoplasm
CEA with Alg9c02021
(de Vreede et al., 2018)
DOES NOT model  cancer
CEA with Hsap\S100A4Δ2.UAS
(Ismail et al., 2017)
model of  carcinoma
CEA with l(2)gl4
(Mishra-Gorur et al., 2019)
CEA with scrib1
(Mishra-Gorur et al., 2019)
CEA with scrib673
(Amcheslavsky et al., 2018)
Ras85DV12.cUa.UAS
model of  cervical cancer
CEA
(Padash Barmchi et al., 2016)
CEA with Hsap\UBE3AUAS.cRa, HPV18\E6UAS.Tag:MYC
(Padash Barmchi et al., 2016)
CEA with Hsap\UBE3AUAS.cRa, HPV18\E6V158A.UAS.Tag:MYC
(Padash Barmchi et al., 2016)
model of  cardiomyopathy
CEA
(Yu et al., 2013)
model of  adenocarcinoma
CEA with l(2)glGD4047
(Casas-Tintó et al., 2016)
CEA with l(2)glGD4047, wupAJF02172
(Casas-Tintó et al., 2016)
model of  colorectal cancer
CEA with p53VDRC.cUa, PtenGD13500, ApcVDRC.cUa, MedVDRC.cUa
(Bangi et al., 2016)
CEA with p53VDRC.cUa, PtenGD13500, ApcVDRC.cUa
(Bangi et al., 2016)
CEA with p53VDRC.cUa, ApcVDRC.cUa, MedVDRC.cUa
(Bangi et al., 2016)
CEA with PtenGD13500, ApcVDRC.cUa, MedVDRC.cUa
(Bangi et al., 2016)
model of  intestinal cancer
CEA with ApcQ8
(Campbell et al., 2019)
model of  carcinoma
CEA with l(2)gl4
(Sun et al., 2019)
model of  cancer
CEA
(Dunn et al., 2018)
Potential Models Based on Orthology ( 25 )
Human Ortholog
Disease
Evidence
References
HRAS; HRas proto-oncogene, GTPase
model of  linear nevus sebaceous syndrome
IEA
(FlyBase, 2019-)
model of  Costello syndrome
IEA
(FlyBase, 2019-)
model of  urinary bladder cancer
IEA
(FlyBase, 2019-)
model of  thyroid gland follicular carcinoma
IEA
(FlyBase, 2019-)
model of  epidermal nevus
IEA
(FlyBase, 2019-)
model of  large congenital melanocytic nevus
IEA
(FlyBase, 2019-)
KRAS; KRAS proto-oncogene, GTPase
model of  Noonan syndrome 3
IEA
(FlyBase, 2019-)
model of  arteriovenous malformations of the brain
IEA
(FlyBase, 2019-)
model of  pancreatic carcinoma
IEA
(FlyBase, 2019-)
model of  breast cancer
IEA
(FlyBase, 2019-)
model of  acute myeloid leukemia
IEA
(FlyBase, 2019-)
model of  cardiofaciocutaneous syndrome 2
IEA
(FlyBase, 2019-)
model of  oculoectodermal syndrome
IEA
(FlyBase, 2019-)
model of  linear nevus sebaceous syndrome
IEA
(FlyBase, 2019-)
model of  lung cancer
IEA
(FlyBase, 2019-)
model of  stomach cancer
IEA
(FlyBase, 2019-)
model of  urinary bladder cancer
IEA
(FlyBase, 2019-)
model of  autoimmune lymphoproliferative syndrome type 4
IEA
(FlyBase, 2019-)
NRAS; NRAS proto-oncogene, GTPase
model of  large congenital melanocytic nevus
IEA
(FlyBase, 2019-)
model of  epidermal nevus
IEA
(FlyBase, 2019-)
model of  thyroid gland follicular carcinoma
IEA
(FlyBase, 2019-)
model of  colorectal cancer
IEA
(FlyBase, 2019-)
model of  Noonan syndrome 6
IEA
(FlyBase, 2019-)
model of  autoimmune lymphoproliferative syndrome type 4
IEA
(FlyBase, 2019-)
model of  linear nevus sebaceous syndrome
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 10 )
Allele
Disease
Interaction
References
Ras85DΔC40B
ameliorates  multiple endocrine neoplasia type 2B
modeled by RetMEN2B.GMR
(Read et al., 2005)
Ras85D06677
ameliorates  autosomal dominant cerebellar ataxia
modeled by Hsap\ATXN182Q.UAS
(Park et al., 2013)
ameliorates  multiple endocrine neoplasia type 2B
modeled by RetMEN2B.GMR
(Read et al., 2005)
ameliorates  multiple endocrine neoplasia type 2A
modeled by RetMEN2A.GMR
(Read et al., 2005)
ameliorates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
Ras85DN17.UAS
ameliorates  brain glioma
modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
(Read et al., 2009)
Ras85DV12.UAS
model of  cancer
is ameliorated by Sec8KK101531
(Chabu and Xu, 2014)
is ameliorated by Sec15KK101708
(Chabu and Xu, 2014)
is ameliorated by Sec6GD11616
(Chabu and Xu, 2014)
is ameliorated by Sec151
(Chabu and Xu, 2014)
is ameliorated by Sec15GD12109
(Chabu and Xu, 2014)
is ameliorated by Src64BGD12263
(Ma et al., 2013)
is exacerbated by Nek2UAS.GFP
(Das et al., 2013)
exacerbates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
exacerbates  gastrointestinal system cancer
modeled by Apc2g10, ApcQ8
(Wang et al., 2013)
model of  colorectal cancer
is exacerbated by imdUAS.cGa
(Bangi et al., 2012)
is ameliorated by TimpUAS.cPa
(Bangi et al., 2012)
is ameliorated by JraNIG.2275R
(Bangi et al., 2012)
is ameliorated by bskDN.UAS
(Bangi et al., 2012)
is ameliorated by bskHMS00777
(Bangi et al., 2012)
is exacerbated by hepAct.UAS
(Bangi et al., 2012)
ameliorates  cancer
modeled by dlg1A40.2
(Parisi et al., 2014)
exacerbates  carcinoma
modeled by scrib1
(Brumby and Richardson, 2003)
exacerbates  intestinal cancer
modeled by Rab11KK108297
(Nie et al., 2019)
exacerbates  cancer
modeled by HipkUAS.Tag:HA
(Blaquiere et al., 2018)
Ras85De1B
ameliorates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
exacerbates  viral infectious disease
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  infectious mononucleosis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  Epstein-Barr virus hepatitis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
ameliorates  gastrointestinal system cancer
modeled by Apc2g10, ApcQ8
(Wang et al., 2013)
exacerbates  tuberous sclerosis
modeled by Tsc1UAS.cTa, gigUAS.cTa
(Tapon et al., 2001)
Ras85De2F
ameliorates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
Ras85Dunspecified
ameliorates  neurofibromatosis
modeled by Nf1E2
(Walker et al., 2006)
Ras85DV12.cUa.UAS
model of  cancer
is exacerbated by M6W186stop
(Dunn et al., 2018)
Ras85DGD12553
ameliorates  colorectal cancer
modeled by Src42ACA.UAS
(Cordero et al., 2014)
modeled by Src64BUAS.cCa
(Cordero et al., 2014)
Ras85DKK108029
ameliorates  colorectal cancer
modeled by Src42ACA.UAS
(Cordero et al., 2014)
modeled by Src64BUAS.cCa
(Cordero et al., 2014)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HRAS; HRas proto-oncogene, GTPase
13 of 15
190020
 
KRAS; KRAS proto-oncogene, GTPase
12 of 15
190070
NRAS; NRAS proto-oncogene, GTPase
10 of 15
164790
RRAS2; RAS related 2
4 of 15
600098
    ERAS; ES cell expressed Ras
    3 of 15
    300437
        RRAS; RAS related
        3 of 15
        165090
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Ras85D - Arc1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - CG31550
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - Droj2
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - Gyc76C
            anti tag coimmunoprecipitation, anti tag western blot
            (Iwashita et al., 2020)
            Ras85D - Nf1
            gtpase assay, autoradiography
            (Walker et al., 2006)
            Ras85D - Nop60B
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - Pi3K92E
            two hybrid, pull down, western blot
            (Orme et al., 2006)
            Ras85D - PyK
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - Raf
            pull down, two hybrid, anti tag coimmunoprecipitation, anti tag western blot
            (Yang and Terman, 2012, Ding et al., 2010, Mishra et al., 2005)
            Ras85D - Rgl
            two hybrid
            (Mirey et al., 2003)
            Ras85D - RpL15
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - RpL21
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - RpL23A
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - RpL24
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - RpL6
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - RpS2
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - RpS27
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - alt
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - cindr
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - cno
            anti tag coimmunoprecipitation, autoradiography, two hybrid
            (Boettner and Van Aelst, 2007, Carmena et al., 2006)
            Ras85D - eIF3i
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - glo
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - lark
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - mod(mdg4)
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            Ras85D - pico
            two hybrid
            (Lyulcheva et al., 2008)
            Ras85D - rau
            pull down, anti tag western blot
            (Sieglitz et al., 2013)
            Ras85D - spri
            anti tag coimmunoprecipitation, anti tag western blot
            (Jekely et al., 2005)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Ras85D
            suppressible
            14-3-3ε
            (Therrien et al., 2000, Chang and Rubin, 1997, Karim et al., 1996)
            Ras85D
            enhanceable
            ago
            (Friedman et al., 2011)
            Ras85D
            suppressible
            Akap200
            (Huang and Rubin, 2000)
            Ras85D|scrib
            suppressible
            Akt1
            (Igaki et al., 2006)
            Ras85D|dlg1
            suppressible
            Akt1
            (Willecke et al., 2011)
            Ras85D
            enhanceable
            alph
            (Baril and Therrien, 2006, Therrien et al., 2000)
            Ras85D
            suppressible
            aop
            (Slack et al., 2015, Karim et al., 1996, Rebay and Rubin, 1995)
            Ras85D
            enhanceable
            aop
            (Therrien et al., 2000, Karim et al., 1996)
            Ras85D
            enhanceable
            aos
            (Voas and Rebay, 2003)
            Ras85D
            suppressible
            Apc
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Apc
            (Bangi et al., 2016)
            Pten|Ras85D
            enhanceable
            Apc
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Apc|Med|Pten
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Apc|Med|Pten|p53
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Apc|Med|p53
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Apc|Pten
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Apc|Pten|p53
            (Bangi et al., 2016)
            Ras85D
            suppressible
            Apc|Pten|p53
            (Bangi et al., 2016)
            Ras85D|l(2)gl
            suppressible
            arm
            (Zhang et al., 2019)
            Atg13|Ras85D|scrib
            suppressible
            Atg8a
            (Katheder et al., 2017)
            Ras85D|scrib
            suppressible
            Atg13
            (Katheder et al., 2017)
            Ras85D|scrib
            suppressible
            Atg13|Atg14
            (Katheder et al., 2017)
            Atg13|Ras85D|scrib
            suppressible
            Atg14
            (Katheder et al., 2017)
            Ras85D|scrib
            suppressible
            Atg14
            (Katheder et al., 2017)
            Ras85D
            suppressible
            ave
            (Roignant et al., 2006)
            Ras85D
            suppressible
            Bap170
            (Rendina et al., 2010)
            Ras85D
            enhanceable
            Bap170
            (Rendina et al., 2010)
            Ras85D
            enhanceable
            baz
            (Pagliarini and Xu, 2003)
            Ras85D
            enhanceable
            bchs
            (Raymond et al., 2004)
            Ras85D|l(2)gl
            suppressible
            ben
            (Ma et al., 2014)
            Ras85D
            enhanceable
            BHD
            (Gaur et al., 2013)
            Ras85D
            suppressible
            BHD
            (Gaur et al., 2013)
            Ras85D|sev
            suppressible
            brm
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            bs
            (Schnorr et al., 2001)
            PpV|Ras85D
            suppressible
            bsk
            (Ma et al., 2017)
            Ras85D
            suppressible
            bsk
            (Ismail et al., 2017, Bangi et al., 2012, Wu et al., 2009, Uhlirova and Bohmann, 2006)
            Ras85D|scrib
            suppressible
            bsk
            (Katheder et al., 2017, Wu et al., 2010, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)
            Ras85D|dlg1
            suppressible
            bsk
            (Katheder et al., 2017)
            Ets21C|Ras85D
            suppressible
            bsk
            (Külshammer et al., 2015)
            Ras85D|fmt
            suppressible
            bsk
            (Ma et al., 2017)
            Ras85D|dor
            suppressible
            bsk
            (Chi et al., 2010)
            Ras85D|Sec15
            suppressible
            bsk
            (Chabu and Xu, 2014)
            Ras85D
            enhanceable
            Btk29A
            (Schnorr et al., 2001)
            Ras85D|sev
            suppressible
            btl
            (Maixner et al., 1998)
            Ras85D
            suppressible
            bul
            (Taguchi et al., 2000)
            Ras85D
            suppressible
            bun
            (Nie et al., 2015)
            Ras85D|scrib
            suppressible
            bur
            (Willoughby et al., 2013)
            Ras85D
            suppressible
            Caper
            (Ashton-Beaucage et al., 2014)
            Ras85D
            enhanceable
            car
            (Chi et al., 2010)
            Ras85D
            suppressible
            Cbl
            (Wang et al., 2008)
            Ras85D
            suppressible
            CCT4
            (Kim and Choi, 2019)
            Ras85D
            enhanceable
            Cdc42
            (Pagliarini and Xu, 2003)
            Ras85D
            suppressible
            CG1603
            (Ashton-Beaucage et al., 2014)
            Ras85D
            enhanceable
            CG4936
            (Ashton-Beaucage et al., 2014)
            Ras85D
            enhanceable
            CG6907
            (Friedman et al., 2011)
            Ras85D
            enhanceable
            CG6984
            (Friedman et al., 2011)
            Ras85D
            suppressible
            CG7483
            (Ashton-Beaucage et al., 2010)
            Ras85D|scrib
            suppressible
            CG9674
            (Willoughby et al., 2013)
            Ras85D
            suppressible
            chb
            (Huang and Rubin, 2000)
            Ras85D|scrib
            suppressible
            cher
            (Külshammer and Uhlirova, 2013)
            Ras85D
            enhanceable
            chic
            (Schnorr et al., 2001)
            Ras85D
            suppressible
            cic
            (Jin et al., 2015, Roch et al., 2002)
            Ras85D
            suppressible
            Cka
            (Ashton-Beaucage et al., 2014)
            Ras85D
            suppressible
            cln
            (Taguchi et al., 2000)
            Ras85D
            suppressible
            cnc
            (Deng and Kerppola, 2013)
            Ras85D
            enhanceable
            cnk
            (Douziech et al., 2003, Zhang and Lu, 2000, Therrien et al., 1999, Therrien et al., 1998)
            Ras85D
            suppressible
            cnk
            (Douziech et al., 2003, Therrien et al., 2000, Zhang and Lu, 2000, Therrien et al., 1999, Zhang et al., 1999, Therrien et al., 1998)
            Ras85D
            enhanceable
            cno
            (Matsuo et al., 1997)
            Ras85D
            suppressible
            CoRest
            (Friedman et al., 2011)
            Ras85D
            suppressible
            CrebB
            (Freeman et al., 2010)
            Ras85D
            suppressible
            Csk
            (Hirabayashi et al., 2013)
            Ras85D
            suppressible
            csw
            (Johnson Hamlet and Perkins, 2001, Firth et al., 2000, Allard et al., 1996)
            Ras85D
            enhanceable
            csw
            (Firth et al., 2000)
            Ras85D
            enhanceable
            CTPsyn
            (Friedman et al., 2011)
            Ras85D|scrib
            suppressible
            CTPsyn
            (Willoughby et al., 2013)
            Ras85D|dlg1
            suppressible
            CycE|stg
            (Willecke et al., 2011)
            Ras85D|scrib
            suppressible
            dap
            (Brumby and Richardson, 2003)
            Ras85D
            suppressible
            dco
            (Friedman et al., 2011)
            Ras85D
            suppressible
            Dg
            (Poulton and Deng, 2006)
            Ras85D
            enhanceable
            dgt2
            (Friedman et al., 2011)
            Ras85D
            suppressible
            Dis3
            (Snee et al., 2016)
            Ras85D
            enhanceable
            Dis3
            (Snee et al., 2016)
            Ras85D
            enhanceable
            DJ-1α
            (Aron et al., 2010)
            Ras85D
            suppressible
            DJ-1α|dj-1β
            (Aron et al., 2010)
            Ras85D|sev
            suppressible
            Dl|tws
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            dlg1
            (Willecke et al., 2011, Pagliarini and Xu, 2003)
            Ras85D
            enhanceable
            dock
            (Schnorr et al., 2001)
            Ras85D|scrib
            suppressible
            dome
            (Katheder et al., 2017, Wu et al., 2010)
            Ras85D
            suppressible
            dome
            (Chabu and Xu, 2014)
            Ras85D|upd1
            suppressible
            dome
            (Wu et al., 2010)
            Ras85D
            enhanceable
            dor
            (Chi et al., 2010)
            Ras85D
            suppressible
            dpp
            (Carmena et al., 1998)
            Ras85D
            suppressible
            Dsor1
            (Zeng et al., 2010, Therrien et al., 2000, Karim et al., 1996, O'Neill et al., 1994)
            Ras85D|scrib
            suppressible
            E2f1
            (Brumby and Richardson, 2003)
            Ras85D
            suppressible
            E(sina)3
            (Carthew et al., 1994)
            Ras85D
            suppressible
            ed
            (Bai et al., 2001)
            Ras85D
            enhanceable
            ed
            (Bai et al., 2001, Hsu et al., 1998)
            Ras85D
            suppressible
            edl
            (Tootle et al., 2003, Yamada et al., 2003)
            Ras85D
            suppressible
            eg
            (Hay et al., 1997)
            Ras85D
            enhanceable
            Egfr
            (Read et al., 2009, Schnorr et al., 2001, Schnorr and Berg, 1996)
            Ras85D|scrib
            suppressible
            egr
            (Katheder et al., 2017, Andersen et al., 2015)
            shg|Ras85D
            enhanceable
            egr
            (Igaki et al., 2006)
            Ras85D
            suppressible
            egr
            (Chabu and Xu, 2014, Wu et al., 2009)
            Ras85D|Uba1
            suppressible
            egr
            (Yan et al., 2009)
            Ras85D
            suppressible
            EK2-5
            (Therrien et al., 2000)
            Ras85D
            suppressible
            EK2-7
            (Therrien et al., 2000)
            Ras85D
            suppressible
            EK3-3
            (Therrien et al., 2000)
            Ras85D
            enhanceable
            EM3-1
            (Taguchi et al., 2000)
            Ras85D
            enhanceable
            ER2-1
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER2-3
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER2-4
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER2-7A
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER2-7B
            (Laverty, 2002.4, Karim et al., 1996)
            Ras85D
            enhanceable
            ER2-8A
            (Laverty, 2002.4)
            Ras85D
            enhanceable
            ER3-2
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER3-3
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER3-4
            (Karim et al., 1996)
            Ras85D
            enhanceable
            ER3-5
            (Karim et al., 1996)
            Ras85D|sev
            suppressible
            eRF1
            (Maixner et al., 1998)
            Ras85D|scrib
            suppressible
            Ets21C
            (Külshammer et al., 2015)
            Ras85D|kay|scrib
            suppressible
            Ets21C
            (Külshammer et al., 2015)
            Ras85D|ftz-f1|scrib
            suppressible
            Ets21C
            (Külshammer et al., 2015)
            Ras85D|scrib
            suppressible
            Ets21C|kay
            (Katheder et al., 2017)
            Ras85D
            enhanceable
            EY2-5
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            EY2-6
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            EY2-8
            (Rebay et al., 2000)
            Ras85D
            suppressible
            EY3-2
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            EY3-3
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            EY3-4
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            EY3-5
            (Rebay et al., 2000)
            Ras85D
            suppressible
            eya
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            eya
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            fmt
            (Ma et al., 2017)
            Ras85D|PpV
            enhanceable
            fmt
            (Ma et al., 2017)
            Ras85D|l(2)gl
            suppressible
            fmt
            (Ma et al., 2017)
            Ras85D|sev
            suppressible
            fray
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            frc
            (Maixner et al., 1998)
            Ras85D|scrib
            suppressible
            ftz-f1
            (Külshammer et al., 2015)
            Ras85D|sev
            suppressible
            ftz-f1
            (Maixner et al., 1998)
            Ets21C|Ras85D|scrib
            suppressible
            ftz-f1
            (Külshammer et al., 2015)
            Ras85D
            suppressible
            fzy
            (Friedman et al., 2011)
            Ras85D|scrib
            suppressible
            Gfat1
            (Willoughby et al., 2013)
            Ras85D
            suppressible
            gfzf
            (Ashton-Beaucage et al., 2014)
            Pten|Ras85D|p53|Apc
            enhanceable
            gig
            (Bangi et al., 2016)
            Ras85D
            suppressible
            gl
            (Carthew et al., 1994)
            Ras85D
            enhanceable
            grk
            (Schnorr et al., 2001, Schnorr and Berg, 1996)
            Ras85D|scrib
            suppressible
            grnd
            (Andersen et al., 2015)
            Ras85D|dlg1
            suppressible
            grnd
            (Andersen et al., 2015)
            Ras85D
            enhanceable
            grp
            (Raymond et al., 2004)
            Ras85D|sev
            suppressible
            HDAC1
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            hep
            (Bangi et al., 2012, Uhlirova and Bohmann, 2006)
            Ras85D|shg
            suppressible
            hep
            (Igaki et al., 2006)
            Ras85D
            enhanceable
            hh
            (Karim et al., 1996)
            Ras85D
            suppressible
            hid
            (Wu et al., 2009)
            Ras85D
            enhanceable
            holn1
            (Geiger et al., 2011)
            Ras85D
            suppressible
            Hr4
            (Ou et al., 2011)
            Ras85D
            suppressible
            htl
            (Schulz and Gajewski, 1999)
            Ras85D
            enhanceable
            imd
            (Bangi et al., 2012)
            Ras85D|dlg1
            suppressible
            ImpL2
            (Figueroa-Clarevega and Bilder, 2015)
            Ras85D|sev
            suppressible
            InR
            (Maixner et al., 1998)
            Ras85D|Csk
            enhanceable
            InR
            (Hirabayashi et al., 2013)
            Ras85D|dlg1
            suppressible
            InR
            (Willecke et al., 2011)
            Csk|Ras85D
            suppressible
            InR
            (Hirabayashi et al., 2013)
            Ras85D
            enhanceable
            IntS3
            (Friedman et al., 2011)
            Ras85D
            suppressible
            Jra
            (Bangi et al., 2012, Peverali et al., 1996)
            Ras85D
            suppressible
            kay
            (Meng and Biteau, 2015, Freeman et al., 2010)
            Ras85D|scrib
            suppressible
            kay
            (Katheder et al., 2017, Külshammer et al., 2015)
            Ets21C|Ras85D|scrib
            suppressible
            kay
            (Külshammer et al., 2015)
            Ras85D
            suppressible
            kis
            (Therrien et al., 2000)
            Ras85D|sev
            suppressible
            kis
            (Maixner et al., 1998)
            Ras85D
            suppressible
            klu
            (Rusconi et al., 2004)
            Ras85D
            enhanceable
            klu
            (Rusconi et al., 2004)
            Ras85D
            suppressible
            ksr::tor
            (Therrien et al., 2000)
            Ras85D
            suppressible
            ksr
            (Therrien et al., 2000, Karim et al., 1996, Therrien et al., 1995)
            Ras85D|sev
            suppressible
            ksr
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            kto
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            l(2)43Bb
            (Schnorr et al., 2001)
            Ras85D
            enhanceable
            l(2)gl
            (Arefin et al., 2017, Ma et al., 2017, Pagliarini and Xu, 2003)
            Ras85D|sev
            suppressible
            l(3)03077
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)03608
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)04704a|l(3)04704b
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)04708
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)05143
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)05820
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)06265
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)06658
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)06734
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)06743
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)06948a|sr
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            l(3)09291
            (Maixner et al., 1998)
            Ras85D|l(2)gl
            suppressible
            lic
            (Sun et al., 2019)
            Ras85D
            suppressible
            lilli
            (Tang et al., 2001, Rebay et al., 2000)
            Ras85D
            enhanceable
            lilli
            (Tang et al., 2001)
            Ras85D
            suppressible
            Lk6
            (Huang and Rubin, 2000)
            Ras85D|Vps15
            suppressible
            Lkb1
            (O'Farrell et al., 2017)
            Ras85D
            suppressible
            Lkb1
            (O'Farrell et al., 2017)
            Ras85D
            enhanceable
            lncRNA:Hsrω
            (Ray and Lakhotia, 2019)
            Ras85D
            suppressible
            mago
            (Ashton-Beaucage et al., 2010)
            Ras85D|sev
            suppressible
            mam
            (Maixner et al., 1998)
            Ras85D
            suppressible
            mam
            (Karim et al., 1996)
            Ras85D
            enhanceable
            mask
            (Smith et al., 2002)
            Ras85D
            suppressible
            mask
            (Smith et al., 2002)
            Ras85D
            enhanceable
            Med|Pten|p53
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            MESK1
            (Huang and Rubin, 2000)
            Ras85D
            enhanceable
            MESK2
            (Schnorr et al., 2001, Huang and Rubin, 2000)
            Ras85D
            enhanceable
            MESK3
            (Huang and Rubin, 2000)
            Ras85D
            enhanceable
            MESK4
            (Huang and Rubin, 2000)
            Ras85D
            suppressible
            MESR3
            (Huang and Rubin, 2000)
            Ras85D
            suppressible
            MESR4
            (Huang and Rubin, 2000)
            Ras85D
            suppressible
            MESR6
            (Huang and Rubin, 2000)
            Ras85D
            enhanceable
            Mi-2
            (Read et al., 2005)
            Ras85D
            suppressible
            Mkp3
            (Jiang et al., 2011, Jiang and Edgar, 2009)
            Ras85D|scrib
            suppressible
            Mmp1
            (Srivastava et al., 2007, Uhlirova and Bohmann, 2006)
            Ras85D|scrib
            suppressible
            Mmp1|Mmp2
            (Uhlirova and Bohmann, 2006)
            Ras85D|scrib
            suppressible
            Mmp2
            (Uhlirova and Bohmann, 2006)
            Ras85D|sev
            suppressible
            mor
            (Maixner et al., 1998)
            Ras85D
            suppressible
            msn
            (Huang and Rubin, 2000)
            Ras85D
            enhanceable
            mts
            (Karim et al., 1996, Wassarman et al., 1996)
            Ras85D
            suppressible
            Myc
            (Prober and Edgar, 2000)
            Ras85D
            suppressible
            N
            (Karim et al., 1996)
            Ras85D|scrib
            suppressible
            Nadsyn
            (Willoughby et al., 2013)
            Ras85D|Csk
            enhanceable
            Nek2
            (Das et al., 2013)
            Ras85D
            suppressible
            NFAT
            (Huang and Rubin, 2000)
            Ras85D|sev
            suppressible
            osa
            (Maixner et al., 1998)
            Ras85D
            suppressible
            osa
            (Terriente-Félix and de Celis, 2009)
            Ras85D
            enhanceable
            osa
            (Terriente-Félix and de Celis, 2009)
            Ras85D
            suppressible
            ovo
            (Payre et al., 1999)
            Ras85D
            enhanceable
            p53
            (Bangi et al., 2016)
            Ras85D
            suppressible
            p53
            (Bangi et al., 2016)
            Pten|Ras85D
            suppressible
            p53
            (Bangi et al., 2016)
            Apc2|Apc|Ras85D
            suppressible
            pan
            (Wang et al., 2013)
            Ras85D|l(2)gl
            suppressible
            pan
            (Zhang et al., 2019)
            Ras85D|scrib
            suppressible
            Pfas
            (Willoughby et al., 2013)
            Ras85D
            suppressible
            phyl
            (Karim et al., 1996, Chang et al., 1995)
            Ras85D|sev
            suppressible
            phyl
            (Maixner et al., 1998)
            Ras85D
            suppressible
            Pi3K92E
            (Willecke et al., 2011)
            Ras85D|dlg1
            suppressible
            Pi3K92E
            (Katheder et al., 2017, Willecke et al., 2011)
            Ras85D
            suppressible
            pico
            (Lyulcheva et al., 2008)
            Ras85D
            suppressible
            Pka-C1
            (Zeng et al., 2010)
            Ras85D
            suppressible
            Plzf
            (Maeng et al., 2012)
            Ras85D
            enhanceable
            Plzf
            (Maeng et al., 2012)
            Ras85D
            suppressible
            pnt
            (Therrien et al., 2000, O'Neill et al., 1994)
            Ras85D|sev
            suppressible
            pnt
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            pnt
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            pnut
            (Schnorr et al., 2001)
            Ras85D
            enhanceable
            POSH
            (Schnorr et al., 2001)
            Ras85D
            suppressible
            Ppm1
            (Friedman and Perrimon, 2006)
            Ras85D|l(2)gl
            suppressible
            PpV
            (Ma et al., 2017)
            Ras85D
            enhanceable
            PpV
            (Ma et al., 2017)
            Ras85D|l(2)gl
            suppressible
            PpV|fmt
            (Ma et al., 2017)
            Ras85D|scrib
            suppressible
            Prat2
            (Willoughby et al., 2013)
            Ras85D|scrib
            suppressible
            Prat
            (Willoughby et al., 2013)
            Ras85D
            suppressible
            Prp19
            (Ashton-Beaucage et al., 2014)
            Ras85D
            suppressible
            Prps
            (Delos Santos et al., 2019)
            Ras85D|sev
            suppressible
            Psa
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            Pss
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            Pten
            (Bangi et al., 2016, Read et al., 2009)
            Ras85D
            suppressible
            Pten
            (Bangi et al., 2016)
            Ras85D|Apc
            enhanceable
            Pten
            (Bangi et al., 2016)
            Ras85D|dlg1
            suppressible
            Pten
            (Willecke et al., 2011)
            Ras85D
            enhanceable
            Pten|p53
            (Bangi et al., 2016)
            Apc|Ras85D
            suppressible
            Pten|p53
            (Bangi et al., 2016)
            Ras85D
            suppressible
            Pten|p53
            (Bangi et al., 2016)
            Ras85D
            enhanceable
            Ptp61F
            (Tchankouo-Nguetcheu et al., 2014)
            Ras85D
            suppressible
            Ptp61F
            (Tchankouo-Nguetcheu et al., 2014)
            Ras85D
            enhanceable
            PTP-ER
            (Karim and Rubin, 1999, Karim et al., 1996)
            Ras85D
            suppressible
            PTP-ER
            (Karim and Rubin, 1999)
            Ras85D|l(2)gl
            suppressible
            puc
            (Sun et al., 2019, Zhang et al., 2019, Ma et al., 2014, Ma et al., 2013, Ma et al., 2013)
            Ras85D
            suppressible
            puc
            (Ma et al., 2013, Uhlirova and Bohmann, 2006)
            Ras85D|scrib
            suppressible
            puc
            (Uhlirova and Bohmann, 2006)
            Ras85D
            suppressible
            puc|scrib
            (Uhlirova and Bohmann, 2006)
            Ras85D|scrib
            suppressible
            r
            (Willoughby et al., 2013)
            Ras85D
            suppressible
            Rab11
            (Yogev et al., 2010)
            Ras85D
            suppressible
            Rabex-5
            (Yan et al., 2010)
            Ras85D
            enhanceable
            Rabex-5
            (Yan et al., 2010)
            Ras85D
            suppressible
            Raf
            (Ray and Lakhotia, 2019, Zeng et al., 2010, Karim and Rubin, 1998, Karim et al., 1996, O'Neill et al., 1994)
            Ras85D|lncRNA:Hsrω
            suppressible
            Raf
            (Ray and Lakhotia, 2019)
            Ras85D
            enhanceable
            Rala
            (Mirey et al., 2003)
            Ras85D
            suppressible
            Rassf
            (Polesello et al., 2006, Polesello et al., 2006)
            Ras85D|scrib
            suppressible
            Reck|Timp
            (Srivastava et al., 2007)
            Ras85D
            enhanceable
            retn
            (Rebay et al., 2000)
            Rala|Ras85D
            suppressible
            Rgl
            (Mirey et al., 2003)
            Ras85D
            enhanceable
            Rgl
            (Mirey et al., 2003)
            Ras85D|dlg1
            suppressible
            Rheb
            (Willecke et al., 2011)
            Ras85D
            suppressible
            Rho1
            (Zeng et al., 2010)
            Ras85D
            suppressible
            rin
            (Pazman et al., 2000)
            Ras85D
            suppressible
            rl
            (Kushnir et al., 2020, Ashton-Beaucage et al., 2014, Gafuik and Steller, 2011, Ashton-Beaucage et al., 2010, Asha et al., 2003, Halfar et al., 2001, Rebay et al., 2000, Therrien et al., 2000, Karim et al., 1996, Peverali et al., 1996, Carthew et al., 1994)
            Ras85D|sev
            suppressible
            rl
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            rl
            (Rebay et al., 2000, Karim and Rubin, 1998)
            Ras85D
            enhanceable
            rno
            (Voas and Rebay, 2003)
            Ras85D
            suppressible
            RpI135
            (Gaur et al., 2013)
            Ras85D|sev
            suppressible
            RpII15
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            RpII140
            (Maixner et al., 1998)
            Ras85D
            enhanceable
            Rpt4
            (Gaur et al., 2013)
            Ras85D
            suppressible
            Rpt4
            (Gaur et al., 2013)
            Ras85D|dlg1
            suppressible
            S6k
            (Willecke et al., 2011)
            Ras85D
            enhanceable
            S6kII
            (Kim et al., 2006)
            Ras85D
            suppressible
            S6kII
            (Kim et al., 2006)
            Ras85D
            enhanceable
            S
            (Held, 2002, Schnorr et al., 2001, Rebay et al., 2000, Taguchi et al., 2000, Ruden et al., 1999)
            Ras85D
            suppressible
            S
            (Taguchi et al., 2000)
            Ras85D
            enhanceable
            santa-maria
            (Hauling et al., 2014)
            Ras85D
            suppressible
            santa-maria
            (Hauling et al., 2014)
            Ras85D
            enhanceable
            scrib
            (Arefin et al., 2017, Uhlirova and Bohmann, 2006, Pagliarini and Xu, 2003)
            Ras85D|dlg1
            suppressible
            sd
            (Katheder et al., 2017)
            Ras85D|scrib
            suppressible
            sds22
            (Jiang et al., 2011)
            Ras85D
            enhanceable
            sds22
            (Jiang et al., 2011)
            Ras85D
            suppressible
            Sec6
            (Chabu and Xu, 2014)
            Ras85D
            suppressible
            Sec8
            (Chabu and Xu, 2014)
            Ras85D|scrib
            suppressible
            Sec15
            (Chabu and Xu, 2014)
            Ras85D
            suppressible
            Sec15
            (Chabu and Xu, 2014)
            Ras85D
            enhanceable
            Sec61β
            (Schnorr et al., 2001)
            Ras85D|scrib
            suppressible
            shg
            (Pagliarini and Xu, 2003)
            Ras85D
            suppressible
            Sin3A
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            SK2-3
            (Therrien et al., 2000)
            Ras85D|sev
            suppressible
            skd
            (Maixner et al., 1998)
            Ras85D
            suppressible
            slbo
            (Lee and Montell, 1997)
            Ras85D|dlg1
            suppressible
            slif
            (Katheder et al., 2017)
            Ras85D
            suppressible
            SM2-1
            (Taguchi et al., 2000)
            Ras85D
            suppressible
            SM3-2
            (Taguchi et al., 2000)
            Ras85D
            suppressible
            SM3-3
            (Taguchi et al., 2000)
            Ras85D
            suppressible
            SM3-6
            (Taguchi et al., 2000)
            Ras85D
            enhanceable
            SM3-6
            (Taguchi et al., 2000)
            Ras85D
            enhanceable
            SM3-8
            (Taguchi et al., 2000)
            Ras85D
            suppressible
            SM3-8
            (Taguchi et al., 2000)
            Ras85D
            enhanceable
            smt3
            (Schnorr et al., 2001)
            Ras85D
            enhanceable
            Socs36E
            (Herranz et al., 2012)
            Ras85D
            enhanceable
            Sos
            (Rebay et al., 2000)
            Ras85D
            suppressible
            Sos
            (Rebay et al., 2000)
            Ras85D|sev
            suppressible
            Sos
            (Maixner et al., 1998)
            Ras85D
            suppressible
            Sox21a
            (Meng and Biteau, 2015)
            Ras85D
            suppressible
            spen
            (Chen and Rebay, 2000, Rebay et al., 2000)
            Ras85D
            enhanceable
            spen
            (Rebay et al., 2000)
            Ras85D
            enhanceable
            spi
            (Wasserman and Freeman, 1998)
            Ras85D
            suppressible
            Spn42Dc
            (Friedman et al., 2011)
            Ras85D
            suppressible
            SR3-2
            (Karim et al., 1996)
            Ras85D
            suppressible
            SR3-6
            (Karim et al., 1996)
            Ras85D|sev
            suppressible
            SR3-7
            (Maixner et al., 1998)
            Ras85D
            suppressible
            SR3-7
            (Karim et al., 1996)
            Ras85D
            suppressible
            SR3-8
            (Karim et al., 1996)
            Ras85D|sev
            suppressible
            SR3-8
            (Maixner et al., 1998)
            Ras85D
            suppressible
            SR3-10
            (Karim et al., 1996)
            Ras85D|l(2)gl
            suppressible
            Src42A
            (Ma et al., 2013)
            Ras85D
            suppressible
            Src42A
            (Ma et al., 2013, Lu and Li, 1999)
            Ras85D
            enhanceable
            Src42A
            (Laberge et al., 2005, Therrien et al., 2000, Lu and Li, 1999)
            Ras85D
            suppressible
            Src64B
            (Ma et al., 2013)
            Ras85D|l(2)gl
            suppressible
            Src64B
            (Ma et al., 2013)
            Ras85D
            enhanceable
            Stat92E
            (Li et al., 2003)
            Ras85D|scrib
            suppressible
            Stat92E
            (Wu et al., 2010)
            Ras85D
            enhanceable
            step
            (Hahn et al., 2013)
            Ras85D
            suppressible
            step
            (Hahn et al., 2013)
            Ras85D
            enhanceable
            stg
            (Rebay et al., 2000)
            Ras85D
            suppressible
            Su(Tpl)
            (Karim et al., 1996)
            Ras85D|sev
            suppressible
            Su(Tpl)
            (Maixner et al., 1998)
            Ras85D
            suppressible
            Tace
            (Chabu and Xu, 2014)
            Ras85D|sev
            suppressible
            Taf1
            (Maixner et al., 1998)
            Ras85D
            suppressible
            Taf1
            (Karim et al., 1996)
            Ras85D
            suppressible
            Taf4
            (Rebay et al., 2000, Karim et al., 1996, Sauer et al., 1996)
            Ras85D|sev
            suppressible
            Taf4
            (Maixner et al., 1998)
            Ras85D
            suppressible
            Taf6
            (Aoyagi and Wassarman, 2001, Karim et al., 1996, Sauer et al., 1996)
            Ras85D|sev
            suppressible
            Taf6
            (Maixner et al., 1998)
            Ras85D
            suppressible
            Taf8
            (Hernandez-Hernandez and Ferrus, 2001)
            Ras85D
            enhanceable
            Taf8
            (Hernandez-Hernandez and Ferrus, 2001)
            PpV|Ras85D
            suppressible
            Tak1
            (Ma et al., 2017)
            Ras85D|l(2)gl
            suppressible
            Tak1
            (Igaki et al., 2006)
            Ras85D
            suppressible
            Tak1
            (Wu et al., 2009)
            Ras85D|fmt
            suppressible
            Tak1
            (Ma et al., 2017)
            Ras85D
            suppressible
            tay
            (Molnar and de Celis, 2013)
            Ras85D
            enhanceable
            tay
            (Molnar and de Celis, 2013)
            Ras85D
            enhanceable
            Tep4
            (Friedman et al., 2011)
            Ras85D
            suppressible
            TfIIA-S
            (Zeidler et al., 1996)
            Ras85D
            suppressible
            Timp
            (Bangi et al., 2012)
            Ras85D|scrib
            suppressible
            Timp
            (Uhlirova and Bohmann, 2006)
            scrib|Ras85D
            enhanceable
            Timp
            (Uhlirova and Bohmann, 2006)
            Ras85D
            suppressible
            Tor
            (Zeng et al., 2010, Berry and Baehrecke, 2007)
            Ras85D|dlg1
            suppressible
            Tor
            (Willecke et al., 2011)
            Ras85D
            suppressible
            Traf4
            (Wu et al., 2009)
            Ras85D|l(2)gl
            suppressible
            Traf6
            (Igaki et al., 2006)
            Ras85D|sev
            suppressible
            Trl
            (Maixner et al., 1998)
            Ras85D|sev
            suppressible
            trx
            (Maixner et al., 1998)
            Pten|Ras85D|p53|Apc
            enhanceable
            Tsc1
            (Bangi et al., 2016)
            Ras85D
            suppressible
            tsu
            (Ashton-Beaucage et al., 2010)
            Ras85D
            enhanceable
            ttk
            (Lai et al., 1996)
            Ras85D
            enhanceable
            twi
            (Halfon et al., 2000)
            Ras85D
            enhanceable
            twi|wg
            (Halfon et al., 2000)