FB2022_03, released June 9, 2022

Gene: Dmel\Ras85D

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General Information
Symbol
Dmel\Ras85D
Species
D. melanogaster
Name
Ras oncogene at 85D
Annotation Symbol
CG9375
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003205
Gene Model Status
Current
Stock Availability
289 publicly available
Enzyme Name (EC)
Heterotrimeric G-protein GTPase (3.6.5.1)
Small monomeric GTPase (3.6.5.2)
Gene Summary
Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Ras, Ras1, Dras1, RasV12, dRas

Key Links
Genomic Location
Cytogenetic map
85D19-85D19
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:9510561..9513067
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (73 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables G protein activity
inferred from direct assay
(Douziech et al., 2006)
enables GTPase activity
inferred from direct assay
(Gafuik and Steller, 2011)
enables protein binding
inferred from physical interaction with FLYBASE:spri; FB:FBgn0085443
(Jekely et al., 2005)
inferred from physical interaction with FLYBASE:Rgl; FB:FBgn0026376
(Mirey et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GDP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (66 terms)
Terms Based on Experimental Evidence (66 terms)
CV Term
Evidence
References
involved_in border follicle cell migration
inferred from mutant phenotype
(Duchek and Rorth, 2001)
involved_in cell fate determination
inferred from mutant phenotype
(Gafuik and Steller, 2011)
involved_in cellular response to starvation
inferred from mutant phenotype
(Hou et al., 2008)
involved_in chorion-containing eggshell pattern formation
inferred from mutant phenotype
(James et al., 2002, Schnorr et al., 2001)
involved_in compound eye development
inferred from mutant phenotype
(Sung et al., 2010, Halfar et al., 2001)
involved_in defense response to virus
inferred from mutant phenotype
(Xu et al., 2013)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Slack et al., 2015)
involved_in dorsal closure, spreading of leading edge cells
inferred from mutant phenotype
(assigned by UniProt )
(Kushnir et al., 2017)
involved_in dorsal closure
inferred from mutant phenotype
(assigned by UniProt )
(Kushnir et al., 2017)
involved_in epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Molnar and de Celis, 2013, Cabernard and Affolter, 2005, Duchek and Rorth, 2001, Yang and Baker, 2001, Diaz-Benjumea and Hafen, 1994)
inferred from genetic interaction with FLYBASE:Egfrap; FB:FBgn0053993
(Soler Beatty et al., 2021)
inferred from genetic interaction with FLYBASE:grk; FB:FBgn0001137
(Schnorr and Berg, 1996)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Schnorr and Berg, 1996)
involved_in epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
inferred from genetic interaction with FLYBASE:btl; FB:FBgn0285896
(Reichman-Fried et al., 1994)
involved_in establishment or maintenance of apical/basal cell polarity
inferred from mutant phenotype
(Poulton and Deng, 2006)
involved_in eye-antennal disc morphogenesis
inferred from mutant phenotype
(Brown et al., 2006)
involved_in fibroblast growth factor receptor signaling pathway
inferred from mutant phenotype
(Ukken et al., 2014, Cabernard and Affolter, 2005, Ohshiro et al., 2002, Michelson et al., 1998)
inferred from genetic interaction with FLYBASE:htl; FB:FBgn0010389
(Schulz and Gajewski, 1999, Michelson et al., 1998, Michelson et al., 1998, Gisselbrecht et al., 1996)
inferred from genetic interaction with FLYBASE:stumps; FB:FBgn0020299
(Imam et al., 1999)
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Vincent et al., 1998)
inferred from direct assay
(Michelson et al., 1998)
involved_in gastrulation
inferred from mutant phenotype
(Li et al., 2003)
involved_in hemocyte migration
inferred from mutant phenotype
(Cho et al., 2002)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006, Pallavi and Shashidhara, 2003)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Gafuik and Steller, 2011)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Hahn et al., 2013, Molnar and de Celis, 2013, Roch et al., 2002)
involved_in instar larval development
inferred from mutant phenotype
(Caldwell et al., 2005)
involved_in intestinal stem cell homeostasis
inferred from mutant phenotype
(Bond and Foley, 2012)
involved_in leg disc proximal/distal pattern formation
inferred from expression pattern
(Galindo et al., 2005)
involved_in lymph gland crystal cell differentiation
inferred from mutant phenotype
(Dragojlovic-Munther and Martinez-Agosto, 2013)
involved_in lymph gland plasmatocyte differentiation
inferred from mutant phenotype
(Dragojlovic-Munther and Martinez-Agosto, 2013)
involved_in Malpighian tubule development
inferred from mutant phenotype
(Zeng et al., 2010)
involved_in MAPK cascade
inferred from mutant phenotype
(assigned by UniProt )
(O'Neill et al., 1994)
involved_in mesodermal cell fate commitment
inferred from mutant phenotype
(Michelson et al., 1998)
inferred from genetic interaction with FLYBASE:htl; FB:FBgn0010389
(Michelson et al., 1998)
involved_in metamorphosis
inferred from mutant phenotype
(Rewitz et al., 2009)
involved_in myoblast fate specification
inferred from genetic interaction with FLYBASE:htl; FB:FBgn0010389
(Schulz and Gajewski, 1999)
involved_in negative regulation of apoptotic process
inferred from mutant phenotype
(Wu et al., 2009, Parker, 2006)
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Chabu and Xu, 2014)
involved_in negative regulation of apoptotic signaling pathway
inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997
(Kurada and White, 1998)
inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706
(Kurada and White, 1998)
involved_in negative regulation of autophagy
inferred from mutant phenotype
(Mohseni et al., 2009)
involved_in negative regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Cordero et al., 2004)
involved_in negative regulation of gene expression
inferred from mutant phenotype
(assigned by UniProt )
(Kushnir et al., 2017)
involved_in negative regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
involved_in ommatidial rotation
inferred from mutant phenotype
(Gaengel and Mlodzik, 2003)
involved_in oocyte axis specification
inferred from mutant phenotype
(Poulton and Deng, 2006)
involved_in peripheral nervous system development
inferred from mutant phenotype
(Sepp and Auld, 2003)
involved_in photoreceptor cell development
inferred from genetic interaction with UniProtKB:P51023
(assigned by UniProt )
(O'Neill et al., 1994)
involved_in photoreceptor cell differentiation
inferred from mutant phenotype
(Yang and Baker, 2001)
involved_in photoreceptor cell fate determination
inferred from genetic interaction with FLYBASE:rho; FB:FBgn0004635
(Freeman, 1994)
involved_in photoreceptor cell morphogenesis
inferred from mutant phenotype
(Gafuik and Steller, 2011)
involved_in positive regulation of cell population proliferation
inferred from mutant phenotype
(Buchon et al., 2010, Jiang and Edgar, 2009, Uhlirova and Bohmann, 2006)
involved_in positive regulation of cell size
inferred from mutant phenotype
(Denton et al., 2012, Sims et al., 2009)
involved_in positive regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Tran et al., 2013, Ohshiro et al., 2002)
inferred from direct assay
(Douziech et al., 2006, Roy et al., 2002)
involved_in positive regulation of hemocyte proliferation
inferred from mutant phenotype
(Arefin et al., 2017)
inferred from genetic interaction with FLYBASE:l(2)gl; FB:FBgn0002121
(Arefin et al., 2017)
inferred from genetic interaction with FLYBASE:scrib; FB:FBgn0263289
(Arefin et al., 2017)
involved_in positive regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Kim et al., 2006)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013)
involved_in R7 cell fate commitment
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Raabe et al., 1996, Fortini et al., 1992, Simon et al., 1991)
inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382, FLYBASE:sev; FB:FBgn0003366
(Allard et al., 1996)
inferred from mutant phenotype
(Karim et al., 1996)
involved_in Ras protein signal transduction
inferred from mutant phenotype
(Ashton-Beaucage et al., 2014)
inferred from high throughput genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Ashton-Beaucage et al., 2014)
involved_in regulation of apoptotic process
inferred from mutant phenotype
(Gafuik and Steller, 2011)
involved_in regulation of cell size
inferred from mutant phenotype
(Wu et al., 2009)
involved_in regulation of growth
inferred from mutant phenotype
(Brumby and Richardson, 2003)
inferred from genetic interaction with FLYBASE:scrib; FB:FBgn0263289
(Brumby and Richardson, 2003)
involved_in regulation of multicellular organism growth
inferred from mutant phenotype
(Caldwell et al., 2005)
involved_in sevenless signaling pathway
inferred from mutant phenotype
(Karim et al., 1996, Kauffmann et al., 1996)
inferred from genetic interaction with FLYBASE:csw; FB:FBgn0000382, FLYBASE:sev; FB:FBgn0003366
(Allard et al., 1996)
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Raabe et al., 1996, Fortini et al., 1992, Simon et al., 1991)
involved_in stem cell differentiation
inferred from mutant phenotype
(Zeng et al., 2010)
involved_in stem cell fate commitment
inferred from mutant phenotype
(Figeac et al., 2010)
involved_in stem cell proliferation
inferred from mutant phenotype
(Zeng et al., 2010)
involved_in terminal branching, open tracheal system
inferred from mutant phenotype
(Ukken et al., 2014)
involved_in terminal region determination
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
(Ambrosio et al., 1989)
involved_in torso signaling pathway
inferred from mutant phenotype
(Mishra et al., 2005, Hou et al., 1995, Lu et al., 1993)
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
(Doyle and Bishop, 1993, Ambrosio et al., 1989)
inferred from genetic interaction with FLYBASE:14-3-3ζ; FB:FBgn0004907
(Li et al., 1997)
involved_in trachea development
inferred from mutant phenotype
(Mortimer and Moberg, 2009)
involved_in tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Bruckner et al., 2004, Cho et al., 2002)
inferred from mutant phenotype
(Tran et al., 2013, Ragab et al., 2011, Sims et al., 2009)
involved_in wing disc morphogenesis
inferred from mutant phenotype
(Pallavi and Shashidhara, 2003)
NOT involved_in dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Harden et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in epidermal growth factor receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002784442
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Ras protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001529867
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from direct assay
(assigned by UniProt )
(Day et al., 2008)
located_in plasma membrane
inferred from direct assay
(Day et al., 2008, Ezer et al., 1994)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Ras family. (P08646)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
GTP + H(2)O = GDP + phosphate (3.6.5.1)
GTP + H(2)O = GDP + phosphate (3.6.5.2)
Predictions / Assertions
-
Summaries
Gene Snapshot
Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
RAS GTPASES -
The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).
Pathway (FlyBase)
Torso Signaling Pathway Core Components -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
Sevenless Signaling Pathway Core Components -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
EGFR Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR Signaling Pathway Core Components -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells (PubMed:11290305). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).
(UniProt, P08646)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ras1: Ras proto-oncogene sequence
Codes for a polypeptide of 21.6 kilodaltons; residues 1-121 and 137-64 exhibit 75% homology with vertebrate H-ras protein.
Summary (Interactive Fly)

ras homolog - establishes follicular cell fate during oogenesis, functions in Torso signal transduction, functions downstream EGF-R in the establishment of ventral ectoderm fate, functions downstream of Breathless in tracheal and midline glia migration, functions downstream of FGF receptor in muscle precursors and in the central nervous system, functions downstream of the EGF-R and Sevenless in differentiation in photoreceptors

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ras85D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P08646)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.41

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ras85D-RA
FBtr0082122
NM_057351
1958
189
Additional Transcript Data and Comments
Reported size (kB)

2.0, 1.3 (northern blot)

(Kimchie et al., 1989)

1.3 (northern blot)

(Segal and Shilo, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ras85D-PA
FBpp0081600
21.6
189
8.01
P08646
NP_476699
AAF54388
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ras85D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in membrane
inferred from direct assay
(assigned by UniProt )
(Day et al., 2008)
located_in plasma membrane
inferred from direct assay
(Day et al., 2008, Ezer et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ras85D in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 64 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 82 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ras85D
Transgenic constructs containing regulatory region of Ras85D
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4elav.PLu
lethal, with Scer\GAL4elav-C155
lethal, with Scer\GAL4en-e16E
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4sca.PU
lethal, with Scer\GAL4sli.PS
lethal | embryonic stage | germline clone | maternal effect | recessive
lethal | heat sensitive, with Scer\GAL4Bx-MS1096
lethal | heat sensitive, with Scer\GAL4dpp.blk1
lethal | maternal effect | recessive
lethal | recessive
lethal | temperature conditional
lethal - all die before end of larval stage, with Scer\GAL4ap.PU
lethal - all die before end of larval stage | recessive
lethal - all die before end of larval stage | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
lethal - all die before end of P-stage, with Scer\GAL4Hml.Δ
lethal - all die before end of P-stage | somatic clone, with Scer\GAL4Act.PU
lethal - all die before end of P-stage | temperature conditional
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL4amn-X8
lethal - all die before end of pupal stage, with Scer\GAL4ap-md544
lethal - all die before end of pupal stage, with Scer\GAL4Bx-MS1096
lethal - all die before end of pupal stage, with Scer\GAL4en-e16E
lethal - all die before end of pupal stage, with Scer\GAL4GMR.PU
lethal - all die before end of pupal stage, with Scer\GAL4MD-638
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage | conditional, with Scer\GAL4Cg.PA
lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4Ras64B.PW
lethal - all die before end of pupal stage | somatic clone, with Scer\GAL4Act.PU
lethal - all die during embryonic stage, with Scer\GAL4ptc.PU
lethal - all die during embryonic stage | maternal effect
lethal - all die during embryonic stage | recessive
lethal - all die during pupal stage, with Scer\GAL4Bx-MS1096
lethal - all die during pupal stage, with Scer\GAL4GMR.PF
partially lethal
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4amn-c651
partially lethal - majority die, with Scer\GAL4ey.PU
partially lethal - majority die, with Scer\GAL4sev.EP
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Cg.PA
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4Hml.Δ
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
viable | somatic clone, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
viable | temperature conditional, with Scer\GAL4Bx-MS1096, Scer\GAL80ts.αTub84B
Sterility
Allele
female semi-sterile
female sterile
female sterile | recessive
Other Phenotypes
Allele
abnormal cell death | somatic clone, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
abnormal cell migration | adult stage, with Scer\GAL4byn-Gal4
abnormal cell migration | adult stage | progressive, with Scer\GAL4byn-Gal4
abnormal cell migration | larval stage, with Scer\GAL4dpp.blk1
abnormal cell number | adult stage, with Scer\GAL4NP0001
abnormal cell polarity
abnormal cell polarity, with Scer\GAL4E(spl)mδ-HLH.0.5
abnormal cell polarity, with Scer\GAL4hs.2sev
abnormal cell polarity | cell autonomous | somatic clone
abnormal cell polarity | cell non-autonomous | somatic clone
abnormal cell polarity | conditional | somatic clone, with Scer\GAL4FRT.Act5C, Scer\GAL80αTub84B.PL
abnormal cell shape | third instar larval stage, with Scer\GAL4ap.PU
abnormal cell size, with Scer\GAL4amn-c651
abnormal developmental rate, with Scer\GAL4phm.PO
abnormal developmental rate | larval stage, with Scer\GAL4amn-c651
abnormal developmental rate | larval stage, with Scer\GAL4amn-X8
abnormal developmental rate | larval stage, with Scer\GAL4phm.PO
abnormal developmental rate | P-stage, with Scer\GAL4GMR.PF
abnormal developmental rate | second instar larval stage, with Scer\GAL4amn-c651
abnormal eclosion rhythm, with Scer\GAL4phm.PO
abnormal endomitotic cell cycle | adult stage, with Scer\GAL4NP0001
abnormal immune response | adult stage
abnormal immune response | adult stage, with Scer\GAL4Cg.PA
abnormal immune response | adult stage, with Scer\GAL4NP5130
abnormal immune response | adult stage | somatic clone
abnormal learning, with Scer\GAL4c739
abnormal learning, with Scer\GAL4c747
abnormal locomotor behavior | larval stage | conditional, with Scer\GAL4Hml.Δ
abnormal mitotic cell cycle | larval stage, with Scer\GAL4GMR.PF
abnormal mitotic cell cycle | maternal effect
abnormal mitotic cell cycle | somatic clone
abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4Bx-MS1096
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4FRT.Act5C
abnormal neuroanatomy, with Scer\GAL4futsch-C380
abnormal neuroanatomy, with Scer\GAL4sca.PC
abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4repo.PU
abnormal neuroanatomy | embryonic stage, with Scer\GAL4repo
abnormal neuroanatomy | larval stage, with Scer\GAL4unspecified
abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4C855a
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4C855a
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Gli-rL82
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4GMR.PF
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo.PU
abnormal neurophysiology
abnormal neurophysiology | larval stage, with Scer\GAL4unspecified
abnormal size, with Scer\GAL4NP0001
abnormal size | adult stage, with Scer\GAL4Bx-MS1096
abnormal size | adult stage, with Scer\GAL4dpp.blk1
abnormal size | adult stage, with Scer\GAL4ey.PH
abnormal size | adult stage | temperature conditional
abnormal size | larval stage, with Scer\GAL4Bx-MS1096
abnormal size | larval stage, with Scer\GAL4dpp.PU
abnormal size | somatic clone | wandering third instar larval stage, with Scer\GAL4Act.PU
abnormal size | third instar larval stage
abnormal size | third instar larval stage, with Scer\GAL4ap-md544
abnormal size | third instar larval stage, with Scer\GAL4Hml.Δ
abnormal sleep | adult stage, with Scer\GAL4Mef2.247.Switch
decreased body size
decreased body size | adult stage, with Scer\GAL4amn-c651
decreased body size | adult stage, with Scer\GAL4Ras64B.PW
decreased body size | larval stage, with Scer\GAL4amn-c651
decreased body size | larval stage, with Scer\GAL4amn-X8
decreased body size | pupal stage, with Scer\GAL4amn-c651
decreased body size | pupal stage, with Scer\GAL4amn-X8
decreased body size | pupal stage, with Scer\GAL4phm.PO
decreased cell death
decreased cell death | embryonic stage, with Scer\GAL4en-e16E
decreased cell death | heat sensitive, with Scer\GAL4hs.PB
decreased cell death | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
decreased cell death | somatic clone | wandering third instar larval stage, with Scer\GAL4Act5C.PI
decreased cell number, with Scer\GAL4C587
decreased cell number | adult stage
decreased cell number | adult stage, with Scer\GAL4NP5130
decreased cell number | adult stage | somatic clone
decreased cell number | larval stage | recessive
decreased cell number | larval stage | somatic clone, with Scer\GAL4Act5C.PP
decreased cell number | prepupal stage P1, with Scer\GAL4NP7397
decreased cell number | third instar larval stage, with Scer\GAL4Hml.Δ
decreased cell size
decreased cell size | adult stage, with Scer\GAL4salm.EPv
decreased cell size | adult stage, with Scer\GAL4Su(H).GBE
decreased cell size | somatic clone
decreased cell size | somatic clone, with Scer\GAL4Act5C.PP
decreased occurrence of cell division | adult stage, with Scer\GAL4byn-Gal4
decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4NP5130
decreased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4NP5130
decreased occurrence of cell division | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
decreased occurrence of cell division | third instar larval stage, with Scer\GAL4ap.PU
decreased occurrence of cell division | third instar larval stage | conditional
decreased size | adult stage, with Scer\GAL4salm.EPv
hyperplasia, with Scer\GAL4dpp.blk1
hyperplasia | conditional, with Scer\GAL4nub.PK
hyperplasia | conditional | somatic clone, with Scer\GAL4FRT.Act5C, Scer\GAL80αTub84B.PL
hyperplasia | larval stage, with Scer\GAL4dpp.blk1
hyperplasia | somatic clone, with Scer\GAL4Act.PU
hyperplasia | somatic clone, with Scer\GAL4FRT.Act5C
hyperplasia | third instar larval stage, with Scer\GAL4ptc-559.1
hyperplasia | third instar larval stage | temperature conditional
increased body size | adult stage, with Scer\GAL4amn-c651
increased body size | pupal stage, with Scer\GAL4amn-c651
increased body size | pupal stage, with Scer\GAL4amn-X8
increased cell death
increased cell death | adult stage, with Scer\GAL4byn-Gal4
increased cell death | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell death | cell non-autonomous | larval stage, with Scer\GAL4Bx-MS1096
increased cell death | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
increased cell death | embryonic stage, with Scer\GAL4en-e16E
increased cell death | somatic clone
increased cell death | third instar larval stage
increased cell death | third instar larval stage, with Scer\GAL4ap.PU
increased cell death | third instar larval stage, with Scer\GAL4en-e16E
increased cell growth, with Scer\GAL4FRT.Act5C
increased cell number, with Scer\GAL4ey.PH
increased cell number, with Scer\GAL4Hml.PG
increased cell number | adult stage
increased cell number | adult stage, with Scer\GAL4esg.PU
increased cell number | adult stage, with Scer\GAL4sev.PU
increased cell number | adult stage | somatic clone, with Scer\GAL4repo.PU
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased cell number | larval stage, with Scer\GAL4He.PZ
increased cell number | larval stage, with Scer\GAL4Hml.Δ
increased cell number | pupal stage, with Scer\GAL4GMR.PF
increased cell number | somatic clone, with Scer\GAL4αTub84B.PL
increased cell number | third instar larval stage, with Scer\GAL4Hml.Δ
increased cell number | third instar larval stage, with Scer\GAL4NP7397
increased cell size, with Scer\GAL4tin.CΔ4
increased cell size | embryonic stage, with Scer\GAL4en-e16E
increased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | third instar larval stage, with Scer\GAL4ap.PU
increased mortality | adult stage | conditional
increased mortality | adult stage | conditional, with Scer\GAL4Cg.PA
increased occurrence of cell division | adult stage, with Scer\GAL4byn-Gal4
increased occurrence of cell division | adult stage, with Scer\GAL4dpp.blk1
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
increased occurrence of cell division | adult stage, with Scer\GAL4NP7397
increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4FRT.Act5C
increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4NP7397
increased occurrence of cell division | larval stage, with Scer\GAL4ey.PU
increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4Act5C.PI
increased occurrence of cell division | somatic clone | third instar larval stage, with Scer\GAL4FRT.Act5C
increased occurrence of cell division | third instar larval stage
increased size | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
increased size | spermatogenesis, with Scer\GAL4VP16.bam
increased size | third instar larval stage, with Scer\GAL4en-e16E
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
long lived | RU486 conditional, with Scer\GAL4Switch1.106
majority die during larval stage, with Scer\GAL4Hml.Δ
majority die during pharate adult stage, with Scer\GAL4sev.EP
majority die during P-stage, with Scer\GAL45015
melanotic mass phenotype, with Scer\GAL4Bx-MS1096
neoplasia | adult stage, with Scer\GAL4ey.PH
neoplasia | adult stage, with Scer\GAL4ey.PU
neoplasia | adult stage | temperature conditional
neoplasia | larval stage, with Scer\GAL4dpp.blk1
neoplasia | larval stage | somatic clone, with Scer\GAL4Act5C.PI
neoplasia | larval stage | somatic clone, with Scer\GAL4Act.PU
neoplasia | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
neoplasia | somatic clone, with Scer\GAL4Act5C.PI
neoplasia | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
neoplasia | somatic clone | third instar larval stage, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
neoplasia | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
neoplasia | somatic clone | third instar larval stage, with Scer\GAL4FRT.Act5C
neoplasia | third instar larval stage, with Scer\GAL4ap.PU
neoplasia | third instar larval stage, with Scer\GAL4ey.PU
neoplasia | third instar larval stage, with Scer\GAL4repo.PU
short lived | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
short lived | RU486 conditional, with Scer\GAL4da.Switch.PT
some die during embryonic stage | maternal effect
some die during embryonic stage | recessive
some die during larval stage, with Scer\GAL4amn-c651
some die during larval stage | recessive
some die during larval stage | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
some die during P-stage | somatic clone, with Scer\GAL4Act.PU
some die during pupal stage
some die during pupal stage, with Scer\GAL4amn-X8
some die during pupal stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4MD-638
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | conditional, with Scer\GAL4Cg.PA
some die during pupal stage | heat sensitive, with Scer\GAL4Ras64B.PW
terminal phenotype | germline clone | maternal effect
visible
visible, with Scer\GAL4bi.PU
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.3KK
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en.PU
visible, with Scer\GAL4ey.3.5.Exel
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4hs.2sev
visible, with Scer\GAL4sca.PU
visible, with Scer\GAL4sca-C253
visible, with Scer\GAL4sev.EP
visible | adult stage, with Scer\GAL4Bx-MS1096
visible | adult stage, with Scer\GAL4ey.PH
visible | adult stage, with Scer\GAL4ey.PU
visible | adult stage, with Scer\GAL4salm.EPv
visible | adult stage, with Scer\GAL4sev.PU
visible | dominant
visible | heat sensitive
visible | pupal stage, with Scer\GAL4MD-638
visible | pupal stage P5, with Scer\GAL4GMR.PF
visible | recessive
visible | recessive | somatic clone
visible | somatic clone, with Ras85DD38E
visible | somatic clone, with Ras85Dx7b
visible | somatic clone, with Scer\GAL4Act5C.PP
wild-type
Phenotype manifest in
Allele
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 1 ventral monoscolopidial chordotonal organ vch1
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 2 ventral monoscolopidial chordotonal organ vch1
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 3 ventral monoscolopidial chordotonal organ vch1
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 4 ventral monoscolopidial chordotonal organ vch1
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 5 ventral monoscolopidial chordotonal organ vch1
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 6 ventral monoscolopidial chordotonal organ vch1
abdominal 7 lateral pentascolopidial chordotonal organ lch5
abdominal 7 ventral monoscolopidial chordotonal organ vch1
abdominal dorsal adult muscle precursor cell, with Scer\GAL4how-24B
abdominal dorso-lateral adult muscle precursor cell, with Scer\GAL4how-24B
abdominal lateral adult muscle precursor cell, with Scer\GAL4how-24B
abdominal neuron | pupal stage P6, with Scer\GAL4GMR.PF
abdominal segment 1
abdominal segment 2
abdominal segment 3
abdominal segment 4
abdominal segment 5
abdominal segment 6
abdominal segment 7
abdominal segment 8
abdominal segment 9
abdominal segment 10
abdominal segment 11
adult abdomen, with Scer\GAL4byn-Gal4
adult brain | somatic clone, with Scer\GAL4repo.PU
adult gut, with Scer\GAL4NP0001
adult gut, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
adult gut, with Scer\GAL4Su(H).GBE
adult head | somatic clone
adult heart, with Scer\GAL4tin.CΔ4
adult heart muscle cell, with Scer\GAL4tin.CΔ4
adult hindgut, with Scer\GAL4byn-Gal4
adult Malpighian tubule | conditional | somatic clone, with Scer\GAL4FRT.Act5C, Scer\GAL80αTub84B.PL
adult Malpighian tubule | somatic clone
adult midgut, with Scer\GAL4NP5130
adult midgut | somatic clone
adult midgut | somatic clone, with Scer\GAL4NP5130
adult midgut | somatic clone, with Scer\GAL4Tub.PU
adult midgut enterocyte, with Scer\GAL4NP0001
adult midgut epithelium, with Scer\GAL4esg.PU
adult midgut progenitor cell | larval stage
adult midgut progenitor cell | prepupal stage P1, with Scer\GAL4NP7397
adult midgut progenitor cell | third instar larval stage, with Scer\GAL4NP7397
adult optic lobe | adult stage | somatic clone, with Scer\GAL4repo.PU
adult posterior midgut epithelium | somatic clone | somatic clone, with Scer\GAL4NP7397
adult pyloric epithelium, with Scer\GAL4byn-Gal4
amnioserosa, with Scer\GAL4Orct2-cald-GAL4
anterior crossvein, with Scer\GAL4dpp.blk1
anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4ptc-559.1
arista, with Scer\GAL4dpp.blk1
border follicle cell
border follicle cell, with Scer\GAL4c306
border follicle cell, with Scer\GAL4hs.PB
border follicle cell, with Scer\GAL4slbo.2.6
bouton | increased number, with Scer\GAL4futsch-C380
bouton | increased number, with Scer\GAL4sca.PC
bract
bract | ectopic | somatic clone, with Scer\GAL4Act.PU
bract | somatic clone
capitellum, with Scer\GAL4dpp.blk1
cardial cell, with Scer\GAL4tin.CΔ4
chaeta | ectopic, with Scer\GAL4dpp.blk1
cone cell
cone cell | heat sensitive
cone cell | precursor
coxa | proximal, with Scer\GAL4dpp.blk1
cyst progenitor cell | male | somatic clone
denticle | ectopic, with Scer\GAL4en-e16E
denticle belt, with Scer\GAL469B
denticle belt, with Scer\GAL4arm.PS
denticle belt, with Scer\GAL4e22c
denticle row 5, with Scer\GAL4arm.PS
denticle row 6, with Scer\GAL4arm.PS
dMP2 neuron, with Scer\GAL4elav.PLu
dorsal acute muscle cell | precursor, with Scer\GAL4twi.PB
dorsal air sac primordium | somatic clone
dorsal air sac primordium | somatic clone, with Scer\GAL4αTub84B.PL
dorsal appendage
dorsal appendage (with Df(3R)by10)
dorsal appendage | maternal effect (with Ras85D05703)
dorsal appendage | maternal effect (with Ras85De1B)
dorsal appendage | somatic clone
dorsal mesothoracic disc & peripodial epithelium | somatic clone, with Scer\GAL4αTub84B.PL
dorsal oblique muscle cell | ectopic | precursor, with Scer\GAL4twi.PB
egg
egg chamber
egg chorion
embryo
embryo | dorsal closure stage, with Scer\GAL4en.PU
embryo | gastrula stage
embryo | germline clone | maternal effect
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4en-e16E
embryonic/first instar larval cuticle | dorsal
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4ptc-559.1
embryonic/larval brain | somatic clone | third instar larval stage, with Scer\GAL4C855a
embryonic/larval brain | third instar larval stage, with Scer\GAL4C855a
embryonic/larval brain | third instar larval stage, with Scer\GAL4repo.PU
embryonic/larval ganglionic tracheal branch 1 | embryonic stage, with Scer\GAL4bs-23.26
embryonic/larval ganglionic tracheal branch, with Scer\GAL4bs-23.26
embryonic/larval hemocyte, with Scer\GAL4srp.Hemo
embryonic/larval hemocyte | decreased number | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval hemocyte | increased number, with Scer\GAL4Cg.PA
embryonic/larval hemocyte | increased number, with Scer\GAL4stop.Hml
embryonic/larval hemocyte | increased number | heat sensitive, with Scer\GAL4Cg.PA
embryonic/larval hemocyte | increased number | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval hemocyte | larval stage | increased number, with Scer\GAL4Hml.Δ
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval hemocyte | third instar larval stage | conditional
embryonic/larval lymph gland, with Scer\GAL4HCH.Hand, Scer\GAL4Hml.Δ
embryonic/larval midgut, with Scer\GAL4NP0001
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4unspecified
embryonic/larval oenocyte | increased number, with Scer\GAL4en-e16E
embryonic/larval peripheral nervous system | third instar larval stage, with Scer\GAL4Gli-rL82
embryonic/larval salivary gland, with Scer\GAL4Bx-MS1096
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic/larval somatic muscle cell, with Scer\GAL4unspecified
embryonic/larval tracheal section, with Scer\GAL4btl.PS
embryonic/larval tracheal system, with Scer\GAL4btl.PS
embryonic abdominal segment 8
embryonic abdominal segment 8 | germline clone
embryonic cardioblast, with Scer\GAL4Mef2.PR
embryonic epidermis, with Scer\GAL469B
embryonic epidermis, with Scer\GAL4e22c
embryonic head | maternal effect
embryonic leading edge cell, with Scer\GAL4en.PU
embryonic midgut constriction 1, with Scer\GAL4how-24B
embryonic segment, with Scer\GAL4en-e16E
enteroblast | adult stage, with Scer\GAL4Su(H).GBE
enteroblast of posterior adult midgut epithelium, with Scer\GAL4NP5130
enterocyte
enterocyte, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
enterocyte, with Scer\GAL4NP7397
enterocyte | somatic clone, with Scer\GAL4unspecified
epithelial cell of wing disc | third instar larval stage, with Scer\GAL4ap.PU
eye
eye, with Scer\GAL4dpp.blk1
eye, with Scer\GAL4ey.3.5.Exel
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye, with Scer\GAL4sev.EP
eye, with Scer\GAL4sev.PU
eye | somatic clone
eye | somatic clone, with Ras85DD38E
eye | somatic clone, with Ras85Dx7b
eye | somatic clone, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
eye | temperature conditional
eye-antennal disc, with Scer\GAL4Act.PU
eye-antennal disc | larval stage, with Scer\GAL4dpp.PU
eye-antennal disc | larval stage | somatic clone, with Scer\GAL4Act5C.PI
eye-antennal disc | somatic clone, with Scer\GAL4Act5C.PI
eye-antennal disc | somatic clone, with Scer\GAL4Act.PU
eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4FRT.Act5C
eye-antennal disc | third instar larval stage | temperature conditional
eye disc, with Scer\GAL4Act5C.PP
eye disc, with Scer\GAL4GMR.PF
eye disc & photoreceptor cell, with Scer\GAL4Act5C.PP
eye disc | heat sensitive
eye disc | heat sensitive, with Scer\GAL4hs.PB
eye disc | larval stage, with Scer\GAL4ey.PU
eye disc | larval stage, with Scer\GAL4GMR.PF
eye disc | somatic clone
eye disc | somatic clone, with Scer\FLP1ey.PU, Scer\GAL4Act.PU
eye disc | somatic clone, with Scer\GAL4Act5C.PI
eye disc | somatic clone, with Scer\GAL4Act5C.PP
eye disc | somatic clone, with Scer\GAL4Act.PU
eye disc | somatic clone | third instar larval stage
eye disc | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
eye disc | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
eye disc | third instar larval stage
eye disc | third instar larval stage, with Scer\GAL4ey.PU
eye disc morphogenetic furrow, with Scer\GAL4dpp.blk1
eye disc morphogenetic furrow | ectopic, with Scer\GAL4dpp.blk1
eye disc morphogenetic furrow | somatic clone, with Scer\GAL4GMR.PF
eye photoreceptor cell
eye photoreceptor cell, with Scer\GAL4sev.PU
eye photoreceptor cell (with Ras85D2F4)
eye photoreceptor cell (with Ras85De2F)
eye photoreceptor cell | adult stage | increased number
eye photoreceptor cell | adult stage | increased number, with Scer\GAL4sev.PU
eye photoreceptor cell | ectopic
eye photoreceptor cell | ectopic, with Scer\GAL4da.G32
fascicle | embryonic stage, with Scer\GAL4repo
fat cell | larval stage, with Scer\GAL4Hml.Δ
female terminalia
filzkorper
filzkorper | embryonic stage | maternal effect
filzkorper | germline clone
follicle cell | somatic clone
fusion competent cell, with Scer\GAL4twi.PB
gastric caecum, with Scer\GAL4NP0001
gastric caecum | somatic clone, with Scer\GAL4Act5C.PP
germarium, with Scer\GAL4unspecified
germline stem cell, with Scer\GAL4C587
germline stem cell | increased number, with Scer\GAL4C587
glial cell, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
glial cell & antennal disc, with Scer\GAL4hs.PB
glial cell | adult stage | somatic clone | increased number, with Scer\GAL4repo.PU
glial cell | increased number | third instar larval stage, with Scer\GAL4repo.PU
haltere pedicel, with Scer\GAL4dpp.blk1
head
head | pharate adult stage | temperature conditional
hemocyte, with Scer\GAL4He.PZ
hemocyte, with Scer\GAL4Hml.PG
hypogynial tooth | ectopic, with Scer\GAL4dpp.blk1
imaginal disc | somatic clone
imaginal disc | somatic clone, with Scer\GAL4Act5C.PP
interface glial cell, with Scer\GAL4S007708-Jan136
interommatidial bristle, with Scer\GAL4hs.2sev
intestinal stem cell
intestinal stem cell, with Scer\GAL4NP0001
intestinal stem cell, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
intestinal stem cell, with Scer\GAL4NP7397
intestinal stem cell | adult stage, with Scer\GAL4NP5130
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4NP5130
intestinal stem cell | somatic clone
lamellocyte | increased number, with Scer\GAL4Bx-MS1096
lamina | third instar larval stage
larval neuroblast | ectopic | somatic clone | third instar larval stage, with Scer\GAL4C855a
larval neuroblast | ectopic | third instar larval stage, with Scer\GAL4C855a
larval optic lobe & glial cell | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PP
larval ventral nerve cord, with Scer\GAL4FRT.Act5C
larval ventral nerve cord | larval stage | somatic clone, with Scer\GAL4Act5C.PI
lipid droplet | larval stage, with Scer\GAL4Hml.Δ
macrochaeta
macrochaeta | ectopic, with Scer\GAL4sca.PU
main body follicle cell | cell autonomous | somatic clone
male terminalia
male terminalia, with Scer\GAL4- :
male terminalia, with Scer\GAL4Pvf1-LP23
Malpighian tubule | pupal stage P5, with Scer\GAL4GMR.PF
Malpighian tubule | pupal stage P6, with Scer\GAL4GMR.PF
medulla cortex & glial cell | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PP
melanotic mass, with Scer\GAL4He.PZ
mesoderm, with Scer\GAL4twi.PG
mesothoracic tarsal segment 1 & bract
mesothoracic tarsal segment 1 & bract | ectopic
mesothoracic tergum, with Scer\GAL4Ubx-lac1-Gal4
mesothoracic tergum & macrochaeta | ectopic, with Scer\GAL4sca-C253
mesothoracic tergum & macrochaeta | supernumerary, with Scer\GAL4sca-C253
mesothoracic tergum | ectopic | larval stage | somatic clone, with Scer\GAL4αTub84B.PL
mesothoracic tibial bract | ectopic
midgut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
midline glial cell
midline glial cell | ectopic, with Scer\GAL4sli.PS
mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
motor neuron | embryonic stage, with Scer\GAL4repo
muscle cell of ventral acute muscle 2 | precursor
muscle founder cell & visceral muscle primordium | ectopic, with Scer\GAL4twi.2PE
muscle founder cell | increased number, with Scer\GAL4twi.PB
myofilament, with Scer\GAL4tin.CΔ4
nurse cell
ommatidial precursor cluster | somatic clone
ommatidial precursor cluster | somatic clone, with Scer\GAL4GMR.PF
ommatidium
ommatidium, with Scer\GAL4E(spl)mδ-HLH.0.5
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4hs.2sev
ommatidium, with Scer\GAL4sev.PU
ommatidium | adult stage, with Scer\GAL4sev.PU
ommatidium | somatic clone | third instar larval stage
oocyte
oocyte | cell non-autonomous | somatic clone
optic cartridge | third instar larval stage, with Scer\GAL4GMR.PF
ovary
pCC neuron, with Scer\GAL4elav.PLu
pericardial cell | ectopic | precursor, with Scer\GAL4twi.PB
pericardial cell primordium | embryonic stage 10
photoreceptor cell & axon & eye disc, with Scer\GAL4bi-omb-Gal4
photoreceptor cell R1
photoreceptor cell R2
photoreceptor cell R2 | somatic clone
photoreceptor cell R3
photoreceptor cell R3 | somatic clone
photoreceptor cell R4
photoreceptor cell R4 | somatic clone
photoreceptor cell R5
photoreceptor cell R5 | somatic clone
photoreceptor cell R6
photoreceptor cell R7
photoreceptor cell R7 | ectopic
photoreceptor cell R7 | increased number
photoreceptor cell R8 | somatic clone | increased number
photoreceptor neuron
photoreceptor neuron (with Ras85D2F4)
photoreceptor neuron (with Ras85De2F)
photoreceptor neuron | ectopic, with Scer\GAL4Act5C.PP
photoreceptor neuron | ectopic, with Scer\GAL4GMR.PF
photoreceptor neuron | increased number, with Scer\GAL4GMR.PF
photoreceptor neuron | P-stage | ectopic, with Scer\GAL4GMR.PF
pigment cell
PNS glial cell | embryonic stage, with Scer\GAL4repo
posterior crossvein
presumptive embryonic/larval peripheral nervous system, with Scer\GAL4repo
primary lobe of embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4Hml.Δ
primordial germ cell | ectopic | maternal effect
prothoracic gland, with Scer\GAL4amn-c651
prothoracic gland, with Scer\GAL4phm.PO
pupa | pupal stage P5, with Scer\GAL4GMR.PF
rhabdomere | increased number, with Scer\GAL4hs.2sev
salivary gland | pupal stage P6, with Scer\GAL4GMR.PF
salivary gland common duct primordium | maternal effect
secondary pigment cell | heat sensitive
secondary pigment cell | precursor
sensory mother cell, with Scer\GAL4sca-C253
sensory neuron & axon & embryo, with Scer\GAL4repo
spectrosome | increased number, with Scer\GAL4unspecified
spermatocyte, with Scer\GAL4VP16.bam
subretinal glial cell & eye disc, with Scer\GAL4bi-omb-Gal4
subretinal glial cell & larval optic stalk, with Scer\GAL4bi-omb-Gal4
tarsal segment, with Scer\GAL4dpp.blk1
tergite
tertiary pigment cell | heat sensitive
tertiary pigment cell | precursor
third segment of antenna, with Scer\GAL4dpp.blk1
tracheal branch primordium, with Scer\GAL4btl.PS
trichoid sensillum | increased number, with Scer\GAL4dpp.blk1
type I bouton
type I bouton | increased number, with Scer\GAL4futsch-C380
vesicle, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
vMP2 neuron, with Scer\GAL4elav.PLu
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4salm.EPv
wing, with Scer\GAL4Ubx-lac1-Gal4
wing cell, with Scer\GAL4salm.EPv
wing disc, with Scer\GAL4ap-md544
wing disc, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4dpp.blk1
wing disc, with Scer\GAL4Gug-AGiR
wing disc, with Scer\GAL4tsh-md621
wing disc, with Scer\GAL4Ubx-lac1-Gal4
wing disc | conditional, with Scer\GAL4nub.PK
wing disc | larval stage, with Scer\GAL4Bx-MS1096
wing disc | larval stage, with Scer\GAL4dpp.blk1
wing disc | larval stage, with Scer\GAL4dpp.PU
wing disc | somatic clone
wing disc | somatic clone | wandering third instar larval stage, with Scer\GAL4Act.PU
wing disc | third instar larval stage, with Scer\GAL4ap.PU
wing disc | third instar larval stage, with Scer\GAL4Bx-MS1096
wing disc | third instar larval stage, with Scer\GAL4en-e16E
wing disc | wandering third instar larval stage, with Scer\GAL4Act5C.PI
wing disc anterior compartment | larval stage, with Scer\GAL4dpp.blk1
wing disc dorsal compartment | third instar larval stage, with Scer\GAL4ap.PU
wing disc dorsal compartment | third instar larval stage, with Scer\GAL4ap-md544
wing disc posterior compartment, with Scer\GAL4en.PU
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en-e16E
wing disc ventral compartment | third instar larval stage, with Scer\GAL4ap.PU
wing hair | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing margin, with Scer\GAL4vg.PU
wing margin | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing vein
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4dpp.3KK
wing vein, with Scer\GAL4dpp.blk1
wing vein, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4MD-638
wing vein | absent, with Scer\GAL4salm.EPv
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4en.PU
wing vein | ectopic, with Scer\GAL4MD-638
wing vein | ectopic, with Scer\GAL4salm.EPv
wing vein | ectopic | increased number, with Scer\GAL4Bx-MS1096
wing vein | ectopic | somatic clone, with Scer\GAL4Act5C.PP
wing vein | heat sensitive
wing vein | increased number
wing vein | somatic clone
wing vein | somatic clone, with Scer\GAL4Act5C.PP
wing vein L2, with Scer\GAL4salm-459.2
wing vein L3, with Scer\GAL4dpp.blk1
wing vein L3, with Scer\GAL4salm-459.2
wing vein L4
wing vein L4, with Scer\GAL4bi.PU
wing vein L4, with Scer\GAL4salm-459.2
wing vein L5
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HRAS
13 of 15
Yes
Yes
2  
Hsap\KRAS
12 of 15
No
Yes
2  
Hsap\NRAS
10 of 15
No
Yes
Hsap\RRAS2
4 of 15
No
No
Hsap\ERAS
3 of 15
No
Yes
Hsap\RRAS
3 of 15
No
No
Hsap\MRAS
2 of 15
No
Yes
Hsap\RAP1A
2 of 15
No
No
3  
Hsap\RAP1B
2 of 15
No
No
3  
Hsap\RALA
1 of 15
No
No
1  
Hsap\RALB
1 of 15
No
No
1  
Hsap\RAP2A
1 of 15
No
No
Hsap\RAP2B
1 of 15
No
No
Hsap\RAP2C
1 of 15
No
No
Hsap\RHEB
1 of 15
No
No
1  
Hsap\RHEBL1
1 of 15
No
No
Hsap\RIT1
1 of 15
No
No
Hsap\RIT2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hras
12 of 15
Yes
Yes
Mmus\Kras
12 of 15
Yes
Yes
Mmus\Nras
10 of 15
No
Yes
Mmus\Rras2
4 of 15
No
No
Mmus\Eras
3 of 15
No
Yes
Mmus\Rras
3 of 15
No
No
Mmus\Mras
2 of 15
No
Yes
Mmus\Rap1a
2 of 15
No
No
Mmus\Rap1b
2 of 15
No
No
Mmus\Rala
1 of 15
No
No
Mmus\Rap2a
1 of 15
No
No
Mmus\Rap2b
1 of 15
No
No
Mmus\Rap2c
1 of 15
No
No
Mmus\Rhebl1
1 of 15
No
No
Mmus\Rheb
1 of 15
No
No
Mmus\Rit1
1 of 15
No
No
Mmus\Rit2
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Hras
11 of 13
Yes
Yes
Rnor\Kras
11 of 13
Yes
Yes
Rnor\Nras
10 of 13
No
Yes
Rnor\Rras2
3 of 13
No
No
Rnor\Eras
2 of 13
No
Yes
Rnor\LOC367858
2 of 13
No
Yes
Rnor\Mras
2 of 13
No
Yes
Rnor\Rras
2 of 13
No
No
Rnor\LOC103690157
1 of 13
No
Yes
Rnor\Rala
1 of 13
No
No
Rnor\Ralb
1 of 13
No
No
Rnor\Rap1a
1 of 13
No
No
Rnor\Rap1b
1 of 13
No
No
Rnor\Rap2a
1 of 13
No
No
Rnor\Rap2b
1 of 13
No
No
Rnor\Rap2c
1 of 13
No
No
Rnor\Rhebl1
1 of 13
No
No
Rnor\Rheb
1 of 13
No
No
Rnor\Rit1
1 of 13
No
No
Rnor\Rit2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\hras
11 of 12
Yes
Yes
Xtro\kras
10 of 12
No
Yes
Xtro\LOC100485959
9 of 12
No
Yes
Xtro\nras
6 of 12
No
Yes
Xtro\rras
3 of 12
No
No
Xtro\mras
2 of 12
No
Yes
Xtro\ralb
2 of 12
No
Yes
Xtro\rap1b
2 of 12
No
No
Xtro\rala
1 of 12
No
No
Xtro\rap1a
1 of 12
No
No
Xtro\rap2a
1 of 12
No
No
Xtro\rap2b
1 of 12
No
No
Xtro\rap2c
1 of 12
No
No
Xtro\rhebl1
1 of 12
No
No
Xtro\rheb
1 of 12
No
No
Xtro\rit1
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\hrasa
12 of 15
Yes
Yes
Drer\hrasb
12 of 15
Yes
Yes
Drer\kras
12 of 15
Yes
Yes
Drer\zgc:55558
10 of 15
No
Yes
Drer\nras
8 of 15
No
Yes
Drer\rras2
4 of 15
No
No
Drer\rras
3 of 15
No
No
Drer\mras
2 of 15
No
Yes
Drer\rap1aa
2 of 15
No
No
Drer\rap1ab
2 of 15
No
No
Drer\rap1b
2 of 15
No
No
Drer\si:ch73-116o1.2
2 of 15
No
Yes
Drer\LOC100332969
1 of 15
No
No
Drer\ralaa
1 of 15
No
No
Drer\ralab
1 of 15
No
No
Drer\ralba
1 of 15
No
No
Drer\rap2ab
1 of 15
No
No
Drer\rap2b
1 of 15
No
No
Drer\rap2c
1 of 15
No
No
Drer\rheb
1 of 15
No
No
Drer\rhebl1
1 of 15
No
No
Drer\rit1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\let-60
15 of 15
Yes
Yes
Cele\ras-1
4 of 15
No
No
Cele\rap-1
2 of 15
No
No
Cele\ras-2
2 of 15
No
Yes
Cele\ral-1
1 of 15
No
No
Cele\rap-2
1 of 15
No
No
Cele\rap-3
1 of 15
No
No
Cele\rheb-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\GB2
1 of 9
Yes
No
Atha\RABA6a
1 of 9
Yes
Yes
Atha\RABB1a
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\RAS2
6 of 15
Yes
No
Scer\RAS1
5 of 15
No
No
Scer\RSR1
2 of 15
No
No
Scer\RHB1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ras1
6 of 12
Yes
No
Spom\rhb1
1 of 12
No
No
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ras64B
7 of 10
Rap1
4 of 10
Rala
3 of 10
Rap2l
3 of 10
Rheb
3 of 10
Ric
3 of 10
CG8500
2 of 10
CG13375
2 of 10
CG5160
1 of 10
CG8519
1 of 10
CG8641
1 of 10
CG14669
1 of 10
CG30158
1 of 10
κB-Ras
1 of 10
Rgk3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Allele
Disease
Evidence
References
Ras85DHMS01294
model of  Noonan syndrome 3
CEA
(Cattaneo et al., 2020)
Ras85DG12V.UAS
model of  cancer
CEA with RhoGEF2RE.UAS
(Khoo et al., 2013)
CEA with RokCAT.UAS
(Khoo et al., 2013)
CEA with sqhE20E21.UAS.cCa
(Khoo et al., 2013)
Ras85DN17.UAS
model of  Noonan syndrome 3
CEA
(Cattaneo et al., 2020)
Ras85DQ13.UAS
model of  cancer
CEA
(Tamamouna et al., 2021)
Ras85DV12.S35.UAS
model of  cardiomyopathy
CEA
(Yu et al., 2013)
Ras85DV12.UAS
model of  cancer
CEA with fmt1
(Ma et al., 2017)
CEA with PpVΔ1
(Ma et al., 2017)
CEA with l(2)gl4
(Ma et al., 2017, Ma et al., 2013, Pagliarini and Xu, 2003)
CEA with PpVGD7532
(Ma et al., 2017)
CEA
(Tamamouna et al., 2021, Rives-Quinto et al., 2017, Chabu and Xu, 2014, Hirabayashi et al., 2013, Ma et al., 2013)
CEA with scrib673
(Katheder et al., 2017)
CEA with scrib1
(Hodgson et al., 2021, Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Külshammer et al., 2015, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)
CEA with dlg1GD4689
(Katheder et al., 2017, Muzzopappa et al., 2017, Figueroa-Clarevega and Bilder, 2015, Willecke et al., 2011)
CEA with scribj7B3
(Pagliarini and Xu, 2003)
CEA with dlg114
(Pagliarini and Xu, 2003)
CEA with baz4
(Pagliarini and Xu, 2003)
CEA with sdtXN
(Pagliarini and Xu, 2003)
CEA with Cdc421
(Pagliarini and Xu, 2003)
CEA with dorC107
(Chi et al., 2010)
CEA with dor8
(Chi et al., 2010)
CEA with dorD185
(Chi et al., 2010)
CEA with cardsRNA.UAS
(Chi et al., 2010)
CEA with Vps16AdsRNA.UAS.WIZ
(Chi et al., 2010)
CEA with upd1UAS.cUa
(Wu et al., 2010)
CEA with upd2UAS.cUa
(Wu et al., 2010)
CEA with upd1UAS.cUa, upd2UAS.cUa, upd3UAS.cUa
(Wu et al., 2010)
CEA with l(2)glunspecified
(Wu et al., 2010)
CEA with pnutGD1512
(Gerlach et al., 2018)
CEA with Hsap\S100A4wt.UAS
(Ismail et al., 2017)
CEA with scribdsRNA.UAS.cUa
(Hodgson et al., 2021)
CEA with CskQ156Stop
(Hirabayashi et al., 2013)
CEA with scribKK101128
(Muzzopappa et al., 2017)
CEA with mudJF02911
(Muzzopappa et al., 2017)
CEA with mudHMS01458
(Muzzopappa et al., 2017)
CEA with NdsRNA.P.UAS
(Tamamouna et al., 2021)
model of  colorectal cancer
CEA
(Bangi et al., 2012)
model of  leukemia
CEA
(Arefin et al., 2017)
CEA with l(2)glKK100777
(Arefin et al., 2017)
CEA with scribKK101128
(Arefin et al., 2017)
model of  benign neoplasm
CEA with Alg9c02021
(de Vreede et al., 2018)
DOES NOT model  cancer
CEA with Hsap\S100A4Δ2.UAS
(Ismail et al., 2017)
model of  carcinoma
CEA
(Ito and Igaki, 2021, Kong et al., 2021, Rackley et al., 2021, Wei et al., 2021, Wu et al., 2021, Murcia et al., 2019, Zoranovic et al., 2018, Igaki et al., 2006)
CEA with Lkb14A4-2
(Rackley et al., 2021)
CEA with l(2)gl4
(Ding et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)
CEA with scrib1
(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)
CEA with dlg114
(Ito and Igaki, 2021, Igaki et al., 2006)
CEA with shgk03401
(Igaki et al., 2006)
CEA with scrib673
(Amcheslavsky et al., 2018)
CEA with msn3208
(Kong et al., 2021)
CEA with snaUAS.cAa
(Wu et al., 2021)
CEA with scribKK101128
(Murcia et al., 2019)
model of  heart disease
CEA
(Karekar et al., 2021)
model of  prostate cancer
CEA
(Rambur et al., 2020)
model of  kidney cancer
CEA
(Zeng et al., 2010)
model of  intestinal cancer
CEA
(Nászai et al., 2021)
model of  hypertrophic cardiomyopathy
CEA
(Petersen et al., 2022)
Ras85DV12.cUa.UAS
model of  cervical cancer
CEA
(Padash Barmchi et al., 2016)
CEA with Hsap\UBE3AUAS.cRa, HPV18\E6UAS.Tag:MYC
(Padash Barmchi et al., 2016)
CEA with Hsap\UBE3AUAS.cRa, HPV18\E6V158A.UAS.Tag:MYC
(Padash Barmchi et al., 2016)
model of  cardiomyopathy
CEA
(Yu et al., 2013)
model of  adenocarcinoma
CEA with l(2)glGD4047
(Casas-Tintó et al., 2016)
CEA with l(2)glGD4047, wupAJF02172
(Casas-Tintó et al., 2016)
model of  colorectal cancer
CEA with p53VDRC.cUa, PtenGD13500, ApcVDRC.cUa, MedVDRC.cUa
(Bangi et al., 2016)
CEA with p53VDRC.cUa, PtenGD13500, ApcVDRC.cUa
(Bangi et al., 2016)
CEA with p53VDRC.cUa, ApcVDRC.cUa, MedVDRC.cUa
(Bangi et al., 2016)
CEA with PtenGD13500, ApcVDRC.cUa, MedVDRC.cUa
(Bangi et al., 2016)
model of  intestinal cancer
CEA with ApcQ8
(Campbell et al., 2019)
CEA
(Singh et al., 2016)
model of  high grade glioma
CEA with PtendsRNA.Exel.UAS
(Gangwani et al., 2020)
model of  carcinoma
CEA with l(2)gl4
(Sun et al., 2019)
model of  cancer
CEA
(Dunn et al., 2018, Vicente et al., 2018)
CEA with scrib1
(Khezri et al., 2021)
Ras85DV152G.UASp
model of  Noonan syndrome 3
CEA
(Cattaneo et al., 2020)
Ras85DV12.QUAS.cHa
model of  cancer
CEA with scrib1
(Hodgson et al., 2021)
Potential Models Based on Orthology ( 25 )
Human Ortholog
Disease
Evidence
References
HRAS; HRas proto-oncogene, GTPase
model of  large congenital melanocytic nevus
IEA
(FlyBase, 2019-)
model of  thyroid gland follicular carcinoma
IEA
(FlyBase, 2019-)
model of  linear nevus sebaceous syndrome
IEA
(FlyBase, 2019-)
model of  urinary bladder cancer
IEA
(FlyBase, 2019-)
model of  Costello syndrome
IEA
(FlyBase, 2019-)
model of  epidermal nevus
IEA
(FlyBase, 2019-)
KRAS; KRAS proto-oncogene, GTPase
model of  urinary bladder cancer
IEA
(FlyBase, 2019-)
model of  linear nevus sebaceous syndrome
IEA
(FlyBase, 2019-)
model of  autoimmune lymphoproliferative syndrome type 4
IEA
(FlyBase, 2019-)
model of  stomach cancer
IEA
(FlyBase, 2019-)
model of  arteriovenous malformations of the brain
IEA
(FlyBase, 2019-)
model of  Noonan syndrome 3
IEA
(FlyBase, 2019-)
model of  cardiofaciocutaneous syndrome 2
IEA
(FlyBase, 2019-)
model of  lung cancer
IEA
(FlyBase, 2019-)
model of  breast cancer
IEA
(FlyBase, 2019-)
model of  acute myeloid leukemia
IEA
(FlyBase, 2019-)
model of  pancreatic carcinoma
IEA
(FlyBase, 2019-)
model of  oculoectodermal syndrome
IEA
(FlyBase, 2019-)
NRAS; NRAS proto-oncogene, GTPase
model of  autoimmune lymphoproliferative syndrome type 4
IEA
(FlyBase, 2019-)
model of  epidermal nevus
IEA
(FlyBase, 2019-)
model of  linear nevus sebaceous syndrome
IEA
(FlyBase, 2019-)
model of  Noonan syndrome 6
IEA
(FlyBase, 2019-)
model of  large congenital melanocytic nevus
IEA
(FlyBase, 2019-)
model of  colorectal cancer
IEA
(FlyBase, 2019-)
model of  thyroid gland follicular carcinoma
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 12 )
Allele
Disease
Interaction
References
Ras85DΔC40B
ameliorates  multiple endocrine neoplasia type 2B
modeled by RetMEN2B.GMR
(Read et al., 2005)
Ras85D06677
ameliorates  autosomal dominant cerebellar ataxia
modeled by Hsap\ATXN182Q.UAS
(Park et al., 2013)
ameliorates  multiple endocrine neoplasia type 2B
modeled by RetMEN2B.GMR
(Read et al., 2005)
ameliorates  multiple endocrine neoplasia type 2A
modeled by RetMEN2A.GMR
(Read et al., 2005)
ameliorates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
Ras85DN17.UAS
ameliorates  brain glioma
modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
(Read et al., 2009)
Ras85DQ13.UAS
model of  cancer
is ameliorated by CatUAS.cAa
(Tamamouna et al., 2021)
is ameliorated by Sod1UAS.cAa
(Tamamouna et al., 2021)
is ameliorated by btlDN.UAS
(Tamamouna et al., 2021)
Ras85DV12.UAS
model of  cancer
is ameliorated by Sec8KK101531
(Chabu and Xu, 2014)
is ameliorated by Sec15KK101708
(Chabu and Xu, 2014)
is ameliorated by Sec6GD11616
(Chabu and Xu, 2014)
is ameliorated by Sec151
(Chabu and Xu, 2014)
is ameliorated by Sec15GD12109
(Chabu and Xu, 2014)
is ameliorated by Src64BGD12263
(Ma et al., 2013)
is exacerbated by CskQ156Stop
(Hirabayashi et al., 2013)
is exacerbated by Nek2UAS.GFP
(Das et al., 2013)
exacerbates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
exacerbates  gastrointestinal system cancer
modeled by Apc2g10, ApcQ8
(Wang et al., 2013)
model of  colorectal cancer
is ameliorated by bskDN.UAS
(Bangi et al., 2012)
is ameliorated by bskHMS00777
(Bangi et al., 2012)
is exacerbated by hepAct.UAS
(Bangi et al., 2012)
is exacerbated by imdUAS.cGa
(Bangi et al., 2012)
is ameliorated by TimpUAS.cPa
(Bangi et al., 2012)
is ameliorated by JraNIG.2275R
(Bangi et al., 2012)
ameliorates  cancer
modeled by dlg1A40.2
(Parisi et al., 2014)
exacerbates  carcinoma
modeled by scrib1
(Brumby and Richardson, 2003)
modeled by armUAS.Exel
(Zhang et al., 2019)
model of  prostate cancer
is ameliorated by EgfrGD1654
(Rambur et al., 2020)
is ameliorated by Pi3K92EHMC05152
(Rambur et al., 2020)
is ameliorated by TorGL00156
(Rambur et al., 2020)
is ameliorated by rlHMS00173
(Rambur et al., 2020)
is ameliorated by spiHMS01120
(Rambur et al., 2020)
exacerbates  intestinal cancer
modeled by Rab11KK108297
(Nie et al., 2019)
exacerbates  cancer
modeled by HipkUAS.Tag:HA
(Blaquiere et al., 2018)
model of  kidney cancer
is ameliorated by Pka-C1B3
(Zeng et al., 2010)
is ameliorated by TorΔP
(Zeng et al., 2010)
model of  carcinoma
is exacerbated by dapHMS01610
(Ito and Igaki, 2021)
is exacerbated by dapHMS05362
(Ito and Igaki, 2021)
is ameliorated by pntP1.UAS
(Ito and Igaki, 2021)
is exacerbated by hepAct.UAS
(Uhlirova and Bohmann, 2006)
is exacerbated by egrUAS.cIa
(Igaki et al., 2006)
is exacerbated by ZnT86DKK101698
(Wei et al., 2021)
is exacerbated by msn172
(Kong et al., 2021)
is exacerbated by msn3208
(Kong et al., 2021)
is exacerbated by l(2)gl4
(Wu et al., 2021)
is exacerbated by snaUAS.cAa
(Wu et al., 2021)
is ameliorated by rlGD4697
(Murcia et al., 2019)
is exacerbated by Tsp29FbGD1018
(Zoranovic et al., 2018)
is ameliorated by Tsp29FbUAS.Tag:HA
(Zoranovic et al., 2018)
is ameliorated by RafDN.UAS
(Zoranovic et al., 2018)
is ameliorated by HAdV-C\E4orf4UAS.cPa
(Rosen et al., 2019)
is ameliorated by HAdV-C\E4orf4UAS.cPb
(Rosen et al., 2019)
Ras85De1B
ameliorates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
exacerbates  viral infectious disease
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  infectious mononucleosis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  Epstein-Barr virus hepatitis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
ameliorates  gastrointestinal system cancer
modeled by Apc2g10, ApcQ8
(Wang et al., 2013)
exacerbates  tuberous sclerosis
modeled by Tsc1UAS.cTa, gigUAS.cTa
(Tapon et al., 2001)
Ras85De2F
ameliorates  alveolar rhabdomyosarcoma
modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
(Galindo et al., 2006)
Ras85Dunspecified
ameliorates  neurofibromatosis
modeled by Nf1E2
(Walker et al., 2006)
Ras85DV12.cUa.UAS
model of  cancer
is exacerbated by Not3KK102144
(Vicente et al., 2018)
is exacerbated by M6W186stop
(Dunn et al., 2018)
Ras85DGD12553
ameliorates  colorectal cancer
modeled by Src42ACA.UAS
(Cordero et al., 2014)
modeled by Src64BUAS.cCa
(Cordero et al., 2014)
ameliorates  neurofibromatosis
modeled by Nf1JF01866
(Georganta et al., 2021)
Ras85DKK108029
ameliorates  colorectal cancer
modeled by Src42ACA.UAS
(Cordero et al., 2014)
modeled by Src64BUAS.cCa
(Cordero et al., 2014)
ameliorates  intestinal cancer
modeled by EgfrUAS.cBa
(Nászai et al., 2021)
Ras85DJF02478
ameliorates  colorectal cancer
modeled by SH3PX1HMJ21552
(Zhang et al., 2019)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HRAS; HRas proto-oncogene, GTPase
13 of 15
190020
 
KRAS; KRAS proto-oncogene, GTPase
12 of 15
190070
 
NRAS; NRAS proto-oncogene, GTPase
10 of 15
164790
RRAS2; RAS related 2
4 of 15
600098
ERAS; ES cell expressed Ras
3 of 15
300437
      RRAS; RAS related
      3 of 15
      165090
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Ras85D - Arc1
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - CG31550
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - Droj2
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - Gyc76C
          anti tag coimmunoprecipitation, anti tag western blot
          (Iwashita et al., 2020)
          Ras85D - Nf1
          gtpase assay, autoradiography
          (Walker et al., 2006)
          Ras85D - Nop60B
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - Pi3K92E
          pull down, western blot, two hybrid
          (Orme et al., 2006)
          Ras85D - PyK
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - Raf
          pull down, two hybrid, anti tag coimmunoprecipitation, anti tag western blot
          (Yang and Terman, 2012, Ding et al., 2010, Mishra et al., 2005)
          Ras85D - Rgl
          two hybrid
          (Mirey et al., 2003)
          Ras85D - RpL15
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - RpL21
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - RpL23A
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - RpL24
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - RpL6
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - RpS2
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - RpS27
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - alt
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - cindr
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - cno
          anti tag coimmunoprecipitation, autoradiography, two hybrid
          (Boettner and Van Aelst, 2007, Carmena et al., 2006)
          Ras85D - eIF3i
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - glo
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - lark
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - mod(mdg4)
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Ras85D - pico
          two hybrid
          (Lyulcheva et al., 2008)
          Ras85D - rau
          pull down, anti tag western blot
          (Sieglitz et al., 2013)
          Ras85D - spri
          anti tag coimmunoprecipitation, anti tag western blot
          (Jekely et al., 2005)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Ras85D
          suppressible
          14-3-3ε
          (Therrien et al., 2000, Chang and Rubin, 1997, Karim et al., 1996)
          Ras85D
          enhanceable
          ago
          (Friedman et al., 2011)
          Ras85D
          suppressible
          Akap200
          (Huang and Rubin, 2000)
          Ras85D|scrib
          suppressible
          Akt
          (Igaki et al., 2006)
          Ras85D|dlg1
          suppressible
          Akt
          (Willecke et al., 2011)
          Ras85D
          enhanceable
          Alg-2
          (Ma et al., 2020)
          Ras85D
          enhanceable
          alph
          (Baril and Therrien, 2006, Therrien et al., 2000)
          Ras85D
          enhanceable
          aop
          (Therrien et al., 2000, Karim et al., 1996)
          Ras85D
          suppressible
          aop
          (Slack et al., 2015, Karim et al., 1996, Rebay and Rubin, 1995)
          Ras85D
          enhanceable
          aos
          (Voas and Rebay, 2003)
          Ras85D
          enhanceable
          Apc
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Apc
          (Bangi et al., 2016)
          Pten|Ras85D
          enhanceable
          Apc
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Apc|Med|Pten
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Apc|Med|Pten|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Apc|Med|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Apc|Pten
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Apc|Pten|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Apc|Pten|p53
          (Bangi et al., 2016)
          Ras85D|l(2)gl
          suppressible
          arm
          (Zhang et al., 2019)
          Atg13|Ras85D|scrib
          suppressible
          Atg8a
          (Katheder et al., 2017)
          Ras85D|scrib
          suppressible
          Atg13
          (Katheder et al., 2017)
          Ras85D|scrib
          suppressible
          Atg13|Atg14
          (Katheder et al., 2017)
          Ras85D|scrib
          suppressible
          Atg14
          (Katheder et al., 2017)
          Atg13|Ras85D|scrib
          suppressible
          Atg14
          (Katheder et al., 2017)
          Ras85D
          suppressible
          ave
          (Roignant et al., 2006)
          Ras85D
          suppressible
          Bap170
          (Rendina et al., 2010)
          Ras85D
          enhanceable
          Bap170
          (Rendina et al., 2010)
          Ras85D
          enhanceable
          baz
          (Pagliarini and Xu, 2003)
          Ras85D
          enhanceable
          bchs
          (Raymond et al., 2004)
          Ras85D|l(2)gl
          suppressible
          ben
          (Ma et al., 2014)
          Ras85D
          enhanceable
          BHD
          (Gaur et al., 2013)
          Ras85D
          suppressible
          BHD
          (Gaur et al., 2013)
          Ras85D|sev
          suppressible
          brm
          (Maixner et al., 1998)
          Ras85D
          enhanceable
          bs
          (Schnorr et al., 2001)
          Ras85D|scrib
          suppressible
          bsk
          (Katheder et al., 2017, Wu et al., 2010, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)
          Orai|Ras85D|Stim
          suppressible
          bsk
          (Ma et al., 2020)
          PpV|Ras85D
          suppressible
          bsk
          (Ma et al., 2017)
          Ras85D|dlg1
          suppressible
          bsk
          (Katheder et al., 2017)
          Ras85D
          suppressible
          bsk
          (Ismail et al., 2017, Bangi et al., 2012, Wu et al., 2009, Uhlirova and Bohmann, 2006)
          Ras85D|emei
          suppressible
          bsk
          (Ma et al., 2020)
          Ets21C|Ras85D
          suppressible
          bsk
          (Külshammer et al., 2015)
          Ras85D|fmt
          suppressible
          bsk
          (Ma et al., 2017)
          Ras85D|msn
          suppressible
          bsk
          (Kong et al., 2021)
          Ras85D|dor
          suppressible
          bsk
          (Chi et al., 2010)
          Ras85D|Sec15
          suppressible
          bsk
          (Chabu and Xu, 2014)
          Ras85D
          enhanceable
          Btk
          (Schnorr et al., 2001)
          Ras85D|sev
          suppressible
          btl
          (Maixner et al., 1998)
          Ras85D
          suppressible
          bul
          (Taguchi et al., 2000)
          Ras85D
          suppressible
          bun
          (Nie et al., 2015)
          Ras85D|scrib
          suppressible
          bur
          (Willoughby et al., 2013)
          Ras85D
          suppressible
          Caper
          (Ashton-Beaucage et al., 2014)
          Ras85D
          enhanceable
          car
          (Chi et al., 2010)
          Ras85D
          suppressible
          Cbl
          (Wang et al., 2008)
          Ras85D
          suppressible
          CCT4
          (Kim and Choi, 2019)
          Ras85D
          enhanceable
          Cdc42
          (Pagliarini and Xu, 2003)
          Ras85D
          suppressible
          CG1603
          (Ashton-Beaucage et al., 2014)
          Ras85D
          enhanceable
          CG4936
          (Ashton-Beaucage et al., 2014)
          Ras85D
          enhanceable
          CG6907
          (Friedman et al., 2011)
          Ras85D
          enhanceable
          CG6984
          (Friedman et al., 2011)
          Ras85D
          suppressible
          CG7483
          (Ashton-Beaucage et al., 2010)
          Ras85D|scrib
          suppressible
          CG9674
          (Willoughby et al., 2013)
          Ras85D
          suppressible
          chb
          (Huang and Rubin, 2000)
          Ras85D|scrib
          suppressible
          cher
          (Külshammer and Uhlirova, 2013)
          Ras85D
          enhanceable
          chic
          (Schnorr et al., 2001)
          Ras85D
          suppressible
          cic
          (Jin et al., 2015, Roch et al., 2002)
          Ras85D
          suppressible
          Ciz1
          (Sun et al., 2020)
          Ras85D
          suppressible
          Cka
          (Ashton-Beaucage et al., 2014)
          Ras85D
          suppressible
          cln
          (Taguchi et al., 2000)
          Ras85D
          suppressible
          cnc
          (Deng and Kerppola, 2013)
          Ras85D
          suppressible
          cnk
          (Douziech et al., 2003, Therrien et al., 2000, Zhang and Lu, 2000, Therrien et al., 1999, Zhang et al., 1999, Therrien et al., 1998)
          Ras85D
          enhanceable
          cnk
          (Douziech et al., 2003, Zhang and Lu, 2000, Therrien et al., 1999, Therrien et al., 1998)
          Ras85D
          enhanceable
          cno
          (Matsuo et al., 1997)
          Ras85D
          suppressible
          CoRest
          (Friedman et al., 2011)
          Ras85D
          suppressible
          CrebB
          (Freeman et al., 2010)
          Ras85D
          suppressible
          Csk
          (Hirabayashi et al., 2013)
          Ras85D
          suppressible
          csw
          (Johnson Hamlet and Perkins, 2001, Firth et al., 2000, Allard et al., 1996)
          Ras85D
          enhanceable
          csw
          (Firth et al., 2000)
          Ras85D|scrib
          suppressible
          CTPsyn
          (Willoughby et al., 2013)
          Ras85D
          enhanceable
          CTPsyn
          (Friedman et al., 2011)
          Ras85D|dlg1
          suppressible
          CycE|stg
          (Willecke et al., 2011)
          Ras85D
          enhanceable
          dap
          (Ito and Igaki, 2021)
          Ras85D|scrib
          suppressible
          dap
          (Brumby and Richardson, 2003)
          Ras85D
          suppressible
          dco
          (Friedman et al., 2011)
          Ras85D
          suppressible
          Dg
          (Poulton and Deng, 2006)
          Ras85D
          enhanceable
          dgt2
          (Friedman et al., 2011)
          Ras85D
          suppressible
          Diap1
          (Soler Beatty et al., 2021)
          Ras85D
          enhanceable
          Dis3
          (Snee et al., 2016)
          Ras85D
          suppressible
          Dis3
          (Snee et al., 2016)
          Ras85D
          enhanceable
          DJ-1α
          (Aron et al., 2010)
          Ras85D
          suppressible
          DJ-1α|dj-1β
          (Aron et al., 2010)
          Ras85D|sev
          suppressible
          Dl|tws
          (Maixner et al., 1998)
          Ras85D
          enhanceable
          dlg1
          (Ito and Igaki, 2021, Willecke et al., 2011, Pagliarini and Xu, 2003)
          Ras85D
          enhanceable
          dock
          (Schnorr et al., 2001)
          Ras85D|upd1
          suppressible
          dome
          (Wu et al., 2010)
          Ras85D|scrib
          suppressible
          dome
          (Katheder et al., 2017, Wu et al., 2010)
          Ras85D
          suppressible
          dome
          (Chabu and Xu, 2014)
          Ras85D
          enhanceable
          dor
          (Chi et al., 2010)
          Ras85D
          suppressible
          dpp
          (Carmena et al., 1998)
          Ras85D
          suppressible
          Dsor1
          (Zeng et al., 2010, Therrien et al., 2000, Karim et al., 1996, O'Neill et al., 1994)
          Ras85D|scrib
          suppressible
          E2f1
          (Brumby and Richardson, 2003)
          Ras85D
          suppressible
          E(sina)3
          (Carthew et al., 1994)
          Ras85D
          suppressible
          ed
          (Bai et al., 2001)
          Ras85D
          enhanceable
          ed
          (Bai et al., 2001, Hsu et al., 1998)
          Ras85D
          suppressible
          edl
          (Tootle et al., 2003, Yamada et al., 2003)
          Ras85D
          suppressible
          eg
          (Hay et al., 1997)
          Ras85D
          enhanceable
          Egfr
          (Read et al., 2009, Schnorr et al., 2001, Schnorr and Berg, 1996)
          Ras85D
          enhanceable
          Egfrap
          (Soler Beatty et al., 2021)
          PVRAP|Ras85D
          enhanceable
          Egfrap
          (Soler Beatty et al., 2021)
          shg|Ras85D
          enhanceable
          egr
          (Igaki et al., 2006)
          Ras85D
          suppressible
          egr
          (Chabu and Xu, 2014, Wu et al., 2009)
          Ras85D|scrib
          suppressible
          egr
          (Katheder et al., 2017, Andersen et al., 2015)
          Ras85D|Uba1
          suppressible
          egr
          (Yan et al., 2009)
          Ras85D
          suppressible
          EK2-5
          (Therrien et al., 2000)
          Ras85D
          suppressible
          EK2-7
          (Therrien et al., 2000)
          Ras85D
          suppressible
          EK3-3
          (Therrien et al., 2000)
          Ras85D
          enhanceable
          EM3-1
          (Taguchi et al., 2000)
          Ras85D
          enhanceable
          emei
          (Ma et al., 2020)
          Ras85D
          enhanceable
          ER2-1
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER2-3
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER2-4
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER2-7A
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER2-7B
          (Laverty, 2002.4, Karim et al., 1996)
          Ras85D
          enhanceable
          ER2-8A
          (Laverty, 2002.4)
          Ras85D
          enhanceable
          ER3-2
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER3-3
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER3-4
          (Karim et al., 1996)
          Ras85D
          enhanceable
          ER3-5
          (Karim et al., 1996)
          Ras85D|sev
          suppressible
          eRF1
          (Maixner et al., 1998)
          Ras85D|kay|scrib
          suppressible
          Ets21C
          (Külshammer et al., 2015)
          Ras85D|scrib
          suppressible
          Ets21C
          (Külshammer et al., 2015)
          Ras85D|ftz-f1|scrib
          suppressible
          Ets21C
          (Külshammer et al., 2015)
          Ras85D|scrib
          suppressible
          Ets21C|kay
          (Katheder et al., 2017)
          Ras85D
          enhanceable
          EY2-5
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          EY2-6
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          EY2-8
          (Rebay et al., 2000)
          Ras85D
          suppressible
          EY3-2
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          EY3-3
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          EY3-4
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          EY3-5
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          eya
          (Rebay et al., 2000)
          Ras85D
          suppressible
          eya
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          fmt
          (Ma et al., 2017)
          Ras85D|l(2)gl
          suppressible
          fmt
          (Ma et al., 2017)
          Ras85D|PpV
          enhanceable
          fmt
          (Ma et al., 2017)
          Ras85D|sev
          suppressible
          fray
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          frc
          (Maixner et al., 1998)
          Ets21C|Ras85D|scrib
          suppressible
          ftz-f1
          (Külshammer et al., 2015)
          Ras85D|scrib
          suppressible
          ftz-f1
          (Külshammer et al., 2015)
          Ras85D|sev
          suppressible
          ftz-f1
          (Maixner et al., 1998)
          Ras85D
          suppressible
          fzy
          (Friedman et al., 2011)
          Ras85D|scrib
          suppressible
          Gfat1
          (Willoughby et al., 2013)
          Ras85D
          suppressible
          gfzf
          (Ashton-Beaucage et al., 2014)
          Pten|Ras85D|p53|Apc
          enhanceable
          gig
          (Bangi et al., 2016)
          Ras85D
          suppressible
          gl
          (Carthew et al., 1994)
          Ras85D
          enhanceable
          grk
          (Schnorr et al., 2001, Schnorr and Berg, 1996)
          Ras85D|scrib
          suppressible
          grnd
          (Andersen et al., 2015)
          Ras85D|dlg1
          suppressible
          grnd
          (Andersen et al., 2015)
          Ras85D
          enhanceable
          grp
          (Raymond et al., 2004)
          Ras85D|sev
          suppressible
          HDAC1
          (Maixner et al., 1998)
          Ras85D|shg
          suppressible
          hep
          (Igaki et al., 2006)
          Ras85D
          enhanceable
          hep
          (Bangi et al., 2012, Uhlirova and Bohmann, 2006)
          Ras85D
          enhanceable
          hh
          (Karim et al., 1996)
          Ras85D
          suppressible
          hid
          (Wu et al., 2009)
          Ras85D
          enhanceable
          holn1
          (Geiger et al., 2011)
          Ras85D
          suppressible
          Hr4
          (Ou et al., 2011)
          Ras85D
          suppressible
          htl
          (Schulz and Gajewski, 1999)
          Ras85D
          enhanceable
          imd
          (Bangi et al., 2012)
          Ras85D|dlg1
          suppressible
          ImpL2
          (Figueroa-Clarevega and Bilder, 2015)
          Ras85D|dlg1
          suppressible
          InR
          (Willecke et al., 2011)
          Ras85D|sev
          suppressible
          InR
          (Maixner et al., 1998)
          Ras85D|Csk
          enhanceable
          InR
          (Hirabayashi et al., 2013)
          Csk|Ras85D
          suppressible
          InR
          (Hirabayashi et al., 2013)
          Ras85D
          enhanceable
          IntS3
          (Friedman et al., 2011)
          Ras85D
          suppressible
          Jra
          (Bangi et al., 2012, Peverali et al., 1996)
          Ras85D|scrib
          suppressible
          kay
          (Katheder et al., 2017, Külshammer et al., 2015)
          Ras85D
          suppressible
          kay
          (Meng and Biteau, 2015, Freeman et al., 2010)
          Ets21C|Ras85D|scrib
          suppressible
          kay
          (Külshammer et al., 2015)
          Ras85D|sev
          suppressible
          kis
          (Maixner et al., 1998)
          Ras85D
          suppressible
          kis
          (Therrien et al., 2000)
          Ras85D
          suppressible
          klu
          (Rusconi et al., 2004)
          Ras85D
          enhanceable
          klu
          (Rusconi et al., 2004)
          Ras85D
          suppressible
          ksr::tor
          (Therrien et al., 2000)
          Ras85D
          suppressible
          ksr
          (Therrien et al., 2000, Karim et al., 1996, Therrien et al., 1995)
          Ras85D|sev
          suppressible
          ksr
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          kto
          (Maixner et al., 1998)
          Ras85D
          enhanceable
          l(2)43Bb
          (Schnorr et al., 2001)
          Ras85D
          enhanceable
          l(2)gl
          (Ito and Igaki, 2021, Arefin et al., 2017, Ma et al., 2017, Pagliarini and Xu, 2003)
          Ras85D|sev
          suppressible
          l(3)03077
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)03608
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)04704a|l(3)04704b
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)04708
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)05143
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)05820
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)06265
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)06658
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)06734
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)06743
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)06948a|sr
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          l(3)09291
          (Maixner et al., 1998)
          Ras85D|l(2)gl
          suppressible
          lic
          (Sun et al., 2019)
          Ras85D
          suppressible
          lilli
          (Tang et al., 2001, Rebay et al., 2000)
          Ras85D
          enhanceable
          lilli
          (Tang et al., 2001)
          Ras85D
          suppressible
          Lk6
          (Huang and Rubin, 2000)
          Ras85D|Vps15
          suppressible
          Lkb1
          (O'Farrell et al., 2017)
          Ras85D
          suppressible
          Lkb1
          (Brown Rackley et al., 2020, O'Farrell et al., 2017)
          Ras85D
          enhanceable
          lncRNA:Hsrω
          (Ray and Lakhotia, 2019)
          Ras85D
          suppressible
          Lztr1
          (Bigenzahn et al., 2018)
          Ras85D
          enhanceable
          Lztr1
          (Bigenzahn et al., 2018)
          Ras85D
          suppressible
          mago
          (Ashton-Beaucage et al., 2010)
          Ras85D
          suppressible
          mam
          (Karim et al., 1996)
          Ras85D|sev
          suppressible
          mam
          (Maixner et al., 1998)
          Ras85D
          suppressible
          mask
          (Smith et al., 2002)
          Ras85D
          enhanceable
          mask
          (Smith et al., 2002)
          Ras85D
          enhanceable
          Med|Pten|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          MESK1
          (Huang and Rubin, 2000)
          Ras85D
          enhanceable
          MESK2
          (Schnorr et al., 2001, Huang and Rubin, 2000)
          Ras85D
          enhanceable
          MESK3
          (Huang and Rubin, 2000)
          Ras85D
          enhanceable
          MESK4
          (Huang and Rubin, 2000)
          Ras85D
          suppressible
          MESR3
          (Huang and Rubin, 2000)
          Ras85D
          suppressible
          MESR4
          (Huang and Rubin, 2000)
          Ras85D
          suppressible
          MESR6
          (Huang and Rubin, 2000)
          Ras85D
          enhanceable
          Mi-2
          (Read et al., 2005)
          Ras85D|l(2)gl
          suppressible
          mir-9c
          (Ito and Igaki, 2021)
          Ras85D|l(2)gl
          suppressible
          mir-79
          (Ito and Igaki, 2021)
          Ras85D|l(2)gl
          suppressible
          mir-ban
          (Ito and Igaki, 2021)
          Ras85D
          suppressible
          Mkp3
          (Jiang et al., 2011, Jiang and Edgar, 2009, Kim et al., 2004)
          Ras85D
          enhanceable
          Mkp3
          (Kim et al., 2004)
          Ras85D|scrib
          suppressible
          Mmp1
          (Srivastava et al., 2007, Uhlirova and Bohmann, 2006)
          Ras85D|scrib
          suppressible
          Mmp1|Mmp2
          (Uhlirova and Bohmann, 2006)
          Ras85D|scrib
          suppressible
          Mmp2
          (Uhlirova and Bohmann, 2006)
          Ras85D|sev
          suppressible
          mor
          (Maixner et al., 1998)
          Ras85D
          enhanceable
          msn
          (Kong et al., 2021)
          Ras85D
          suppressible
          msn
          (Kong et al., 2021, Huang and Rubin, 2000)
          Ras85D|scrib
          suppressible
          msn
          (Kong et al., 2021)
          Ras85D
          enhanceable
          mts
          (Karim et al., 1996, Wassarman et al., 1996)
          Ras85D
          suppressible
          Myc
          (Prober and Edgar, 2000)
          Ras85D
          suppressible
          N
          (Karim et al., 1996)
          Ras85D|scrib
          suppressible
          Nadsyn
          (Willoughby et al., 2013)
          Ras85D|Csk
          enhanceable
          Nek2
          (Das et al., 2013)
          Ras85D
          suppressible
          NFAT
          (Huang and Rubin, 2000)
          Ras85D
          enhanceable
          Not3
          (Vicente et al., 2018)
          Ras85D
          enhanceable
          Orai|Stim
          (Ma et al., 2020)
          Ras85D
          enhanceable
          osa
          (Terriente-Félix and de Celis, 2009)
          Ras85D
          suppressible
          osa
          (Terriente-Félix and de Celis, 2009)
          Ras85D|sev
          suppressible
          osa
          (Maixner et al., 1998)
          Ras85D
          suppressible
          ovo
          (Payre et al., 1999)
          Ras85D
          enhanceable
          p53
          (Bangi et al., 2016)
          Ras85D
          suppressible
          p53
          (Bangi et al., 2016)
          Pten|Ras85D
          suppressible
          p53
          (Bangi et al., 2016)
          Ras85D|l(2)gl
          suppressible
          pan
          (Zhang et al., 2019)
          Apc2|Apc|Ras85D
          suppressible
          pan
          (Wang et al., 2013)
          Ras85D|scrib
          suppressible
          Pfas
          (Willoughby et al., 2013)
          Ras85D|sev
          suppressible
          phyl
          (Maixner et al., 1998)
          Ras85D
          suppressible
          phyl
          (Karim et al., 1996, Chang et al., 1995)
          Ras85D|dlg1
          suppressible
          Pi3K92E
          (Katheder et al., 2017, Willecke et al., 2011)
          Ras85D
          suppressible
          Pi3K92E
          (Willecke et al., 2011)
          Ras85D
          suppressible
          pico
          (Lyulcheva et al., 2008)
          Ras85D
          suppressible
          Pka-C1
          (Zeng et al., 2010)
          Ras85D
          enhanceable
          Plzf
          (Maeng et al., 2012)
          Ras85D
          suppressible
          Plzf
          (Maeng et al., 2012)
          Ras85D
          suppressible
          pnt
          (Ito and Igaki, 2021, Therrien et al., 2000, O'Neill et al., 1994)
          Ras85D|l(2)gl
          suppressible
          pnt
          (Ito and Igaki, 2021)
          Ras85D
          enhanceable
          pnt
          (Ito and Igaki, 2021, Rebay et al., 2000)
          Ras85D|sev
          suppressible
          pnt
          (Maixner et al., 1998)
          Ras85D|dlg1
          suppressible
          pnt
          (Ito and Igaki, 2021)
          Ras85D
          enhanceable
          pnut
          (Schnorr et al., 2001)
          Ras85D
          suppressible
          Polr1B
          (Gaur et al., 2013)
          Ras85D|sev
          suppressible
          Polr2B
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          Polr2I
          (Maixner et al., 1998)
          Ras85D
          enhanceable
          POSH
          (Ma et al., 2020, Schnorr et al., 2001)
          Ras85D|emei
          suppressible
          POSH
          (Ma et al., 2020)
          Ras85D
          suppressible
          Ppm1
          (Friedman and Perrimon, 2006)
          Ras85D|l(2)gl
          suppressible
          PpV
          (Ma et al., 2017)
          Ras85D
          enhanceable
          PpV
          (Ma et al., 2017)
          Ras85D|l(2)gl
          suppressible
          PpV|fmt
          (Ma et al., 2017)
          Ras85D|scrib
          suppressible
          Prat2
          (Willoughby et al., 2013)
          Ras85D|scrib
          suppressible
          Prat
          (Willoughby et al., 2013)
          Ras85D
          suppressible
          Prp19
          (Ashton-Beaucage et al., 2014)
          Ras85D|sev
          suppressible
          Psa
          (Maixner et al., 1998)
          Ras85D|sev
          suppressible
          Pss
          (Maixner et al., 1998)
          Ras85D
          enhanceable
          Pten
          (Bangi et al., 2016, Read et al., 2009)
          Ras85D|Apc
          enhanceable
          Pten
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Pten
          (Bangi et al., 2016)
          Ras85D|dlg1
          suppressible
          Pten
          (Willecke et al., 2011)
          Ras85D
          enhanceable
          Pten|p53
          (Bangi et al., 2016)
          Apc|Ras85D
          suppressible
          Pten|p53
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Pten|p53
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Ptp61F
          (Tchankouo-Nguetcheu et al., 2014)
          Ras85D
          enhanceable
          Ptp61F
          (Tchankouo-Nguetcheu et al., 2014)
          Ras85D
          enhanceable
          PTP-ER
          (Karim and Rubin, 1999, Karim et al., 1996)
          Ras85D
          suppressible
          PTP-ER
          (Karim and Rubin, 1999)
          Ras85D|l(2)gl
          suppressible
          puc
          (Ding et al., 2022, Sun et al., 2019, Zhang et al., 2019, Ma et al., 2014, Ma et al., 2013, Ma et al., 2013)
          Ras85D|scrib
          suppressible
          puc
          (Uhlirova and Bohmann, 2006)
          Ras85D
          suppressible
          puc
          (Ma et al., 2013, Uhlirova and Bohmann, 2006)
          Ras85D
          suppressible
          puc|scrib
          (Uhlirova and Bohmann, 2006)
          Ras85D|Egfrap
          enhanceable
          PVRAP
          (Soler Beatty et al., 2021)
          Ras85D
          enhanceable
          PVRAP
          (Soler Beatty et al., 2021)
          Ras85D|scrib
          suppressible
          r
          (Willoughby et al., 2013)
          Ras85D
          suppressible
          Rab11
          (Yogev et al., 2010)
          Ras85D
          suppressible
          Rabex-5
          (Yan et al., 2010)
          Ras85D
          enhanceable
          Rabex-5
          (Yan et al., 2010)
          Ras85D
          suppressible
          Raf
          (Ray and Lakhotia, 2019, Zeng et al., 2010, Karim and Rubin, 1998, Karim et al., 1996, O'Neill et al., 1994)
          Ras85D|lncRNA:Hsrω
          suppressible
          Raf
          (Ray and Lakhotia, 2019)
          Ras85D
          enhanceable
          Rala
          (Mirey et al., 2003)
          Ras85D
          suppressible
          Ras64B
          (Vega-Cuesta et al., 2020)
          Ras85D
          enhanceable
          Ras64B
          (