FlyBase Gene Report: Dmel\Rm62

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

embryonic stage 13 -- 16

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Dorer et al., 1990)

larval stage

(Dorer et al., 1990)

(Dorer et al., 1990)

Additional Descriptive Data

Isoform-specific expression patterns are observed. Sex-specific expression of alternative transcripts observed.

(Telonis-Scott et al., 2009)

Rm62 transcripts are detected on northern blots in all developmental stages tested.

(Dorer et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult head

• membrane

(Aradska et al., 2015)

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Lamiable et al., 2010)

larval stage

wing disc

(Lamiable et al., 2010)

haltere disc

(Lamiable et al., 2010)

first instar larval stage

leg disc

(Lamiable et al., 2010)

third instar larval stage

leg disc

(Lamiable et al., 2010)

adult stage | female

ovary

(Lamiable et al., 2010)

adult stage | male

testis

(Lamiable et al., 2010)

adult head

(Lamiable et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in cytoplasm

inferred from high throughput direct assay

(Lee et al., 2014)

located_in nucleus

inferred from high throughput direct assay

(Lye et al., 2014)

inferred from direct assay

(Gerbasi et al., 2011)

located_in polytene chromosome puff

inferred from direct assay

(Buszczak and Spradling, 2006)

located_in polytene chromosome

inferred from direct assay

(Lamiable et al., 2010)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

Reporter: PBac{806.LOX-SVS-2}Rm62^CPTI004179

Stage

Tissue/Position (including subcellular localization)

Reference

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rm62 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rm62

View exonic expression by tissue for Dmel\Rm62

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003261

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40739/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003261

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003261

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003261

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10279

Flygut - An atlas of the Drosophila adult midgut

FBgn0003261

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 40 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rm62

Transgenic constructs containing regulatory region of Rm62

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(3R)BSC194

(Gresens and Cook, 2006.12.5)

Df(3R)BSC319

(Christensen et al., 2007.10.29)

Df(3R)BSC320

(Christensen et al., 2007.10.29)

Df(3R)BSC464

(Christensen et al., 2008.4.15)

Df(3R)Tpl^JE5

(Smoyer et al., 2003)

Gene duplicated in

Dp(3;3)Tpl^JE19

(Smoyer et al., 2003)

Gene not disrupted in

Df(3R)Tpl10

(BDGP Project Members, 1994-1999)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Rm62⁰¹⁰⁸⁶

lethal, with Scer\GAL4^Act5C.PI

Rm62^KK112269

lethal, with Scer\GAL4^Act88F.PU

Rm62^KK112269

lethal, with Scer\GAL4^en.PU

Rm62^KK112269

lethal, with Scer\GAL4^insc-Mz1407

Rm62^GD17219

lethal, with Scer\GAL4^Mef2.PU

lethal, with Scer\GAL4^nub.PK

Rm62^KK112269

lethal (with Rm62⁰¹⁰⁸⁶)

lethal (with Rm62^CB02119)

lethal (with Rm62^D)

Rm62⁰¹⁰⁸⁶

lethal (with Rm62^F)

lethal (with Rm62^H)

lethal (with Rm62^K)

lethal | female limited, with Scer\GAL4^dome-PG14

Rm62^HMS00144

lethal | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Rm62^GD17219

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rm62^GD17219

viable, with Scer\GAL4^tin.CΔ4

Rm62^GD17219

viable (with Rm62⁰¹⁰⁸⁶)

Rm62^E

viable (with Rm62^CB02119)

viable (with Rm62^D)

Rm62^CB02119

viable (with Rm62^E)

Sterility

Allele

female sterile

Rm62^CB02119

female sterile, with Scer\GAL4^VP16.otu

Rm62^HMS00144

male sterile

Rm62^CB02119

sterile

Rm62^CB02119

sterile (with Rm62⁰¹⁰⁸⁶)

Rm62^CB02119

sterile (with Rm62^CB02119)

Rm62⁰¹⁰⁸⁶

Other Phenotypes

Allele

abnormal developmental rate | larval stage (with Rm62^CB02119)

Rm62^F

abnormal developmental rate | larval stage (with Rm62^F)

Rm62^CB02119

abnormal flight, with Scer\GAL4^Act88F.PU

Rm62^JF01385

abnormal immune response, with Scer\GAL4^hs.PU

Rm62^JF01385

abnormal immune response (with Rm62⁰¹⁰⁸⁶)

Rm62^CB02119

abnormal immune response (with Rm62^CB02119)

Rm62⁰¹⁰⁸⁶

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Rm62^GD17219

abnormal size | adult stage, with Scer\GAL4^ey.PH

Rm62^KK112269

abnormal size | pharate adult stage, with Scer\GAL4^Act88F.PU

Rm62^JF01385

flightless, with Scer\GAL4^Mef2.PR

Rm62^GD17219

some die during pupal stage, with Scer\GAL4^pnr-MD237

Rm62^GD17219

visible, with Scer\GAL4^nub-AC-62

Rm62^HMS00144

visible, with Scer\GAL4^pnr-MD237

Rm62^GD17219

visible | adult stage, with Scer\GAL4^ey.PH

Rm62^KK112269

visible | adult stage, with Scer\GAL4^GMR.PF

Rm62^KK112269

visible | dominant

Rm62^E

Phenotype manifest in

Allele

dorsocentral bristle (with Rm62⁰¹⁰⁸⁶)

Rm62^CB02119

dorsocentral bristle (with Rm62^CB02119)

Rm62⁰¹⁰⁸⁶

egg chamber (with Rm62⁰¹⁰⁸⁶)

Rm62^CB02119

egg chamber (with Rm62^CB02119)

Rm62⁰¹⁰⁸⁶

eye, with Scer\GAL4^ey.PH

Rm62^KK112269

eye, with Scer\GAL4^GMR.PF

Rm62^KK112269

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Rm62^GD17219

indirect flight muscle cell | pharate adult stage, with Scer\GAL4^Act88F.PU

Rm62^JF01385

larval multidendritic class IV neuron | somatic clone, with Scer\GAL4^Act.PU

mesonotum, with Scer\GAL4^pnr-MD237

Rm62^GD17219

myofibril | pharate adult stage, with Scer\GAL4^Act88F.PU

Rm62^JF01385

nurse cell & nuclear chromosome (with Rm62⁰¹⁰⁸⁶)

Rm62^CB02119

nurse cell & nuclear chromosome (with Rm62^CB02119)

Rm62⁰¹⁰⁸⁶

pigment cell

scutellar bristle (with Rm62⁰¹⁰⁸⁶)

Rm62^CB02119

scutellar bristle (with Rm62^CB02119)

Rm62⁰¹⁰⁸⁶

trichogen cell, with Scer\GAL4^pnr-MD237

Rm62^GD17219

wing, with Scer\GAL4^nub-AC-62

Rm62^HMS00144

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\DDX17

9 of 14

Yes

Hsap\DDX5

8 of 14

Hsap\DDX21

3 of 14

Yes

Hsap\DDX50

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\TDRD12

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Ddx5

8 of 14

Yes

Rnor\Ddx17

8 of 14

Yes

Rnor\Ddx21

3 of 14

Yes

Rnor\Ddx50

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Tdrd12

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (30)

Mmus\Ddx17

9 of 14

Yes

Mmus\Ddx5

8 of 14

Mmus\Ddx21

3 of 14

Yes

Mmus\Ddx50

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Tdrd12

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (18)

Xtro\zbtb1

4 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (23)

Drer\ddx17

9 of 14

Yes

Drer\ddx5

8 of 14

Drer\ddx21

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\ddx-17

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP003663

9 of 12

Yes

Agam\AgaP_AGAP005652

6 of 12

Agam\AgaP_AGAP005351

5 of 12

Yes

4 of 12

4 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (54)

Atha\RH20

11 of 13

Yes

Atha\AT5G63120

10 of 13

Atha\AT5G14610

5 of 13

Yes

Atha\DRH1

5 of 13

Yes

Atha\AT3G06480

4 of 13

Yes

Atha\AT3G06980

3 of 13

Yes

Atha\emb1138

3 of 13

Yes

Atha\PRH75

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\PMH2

2 of 13

Yes

Atha\RH36

2 of 13

Atha\RH39

2 of 13

Atha\STRS1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (24)

Scer\DBP2

11 of 13

Yes

Scer\DBP1

2 of 13

Scer\DBP3

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (15)

Spom\dbp2

11 of 12

Yes

Spom\dbp3

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (4)

Ecol\rhlE

5 of 11

Yes

Ecol\deaD

3 of 11

Ecol\dbpA

1 of 11

Ecol\rhlB

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rm62. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (32)

CG10077

11 of 13

mahe

11 of 13

CG7878

6 of 13

vas

6 of 13

bel

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

abs

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

ais

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

pit

2 of 13

pths

2 of 13

Rs1

2 of 13

BoYb

1 of 13

Dbp73D

1 of 13

SoYb

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Rm62^HMS00144

model of alcohol use disorder

CEA

(Petruccelli et al., 2020)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

Rm62^JF01385

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Rm62^UAS.cUa

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.Tag:HA

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Fortuna et al., 2021)

Rm62^RNAi.UAS.cUa

exacerbates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.Tag:HA

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Fortuna et al., 2021)

Rm62^unspecified

exacerbates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.Tag:HA

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Fortuna et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DDX17; DEAD-box helicase 17

9 of 14

608469

DDX5; DEAD-box helicase 5

8 of 14

180630

DDX21; DExD-box helicase 21

3 of 14

606357

DDX50; DExD-box helicase 50

3 of 14

610373

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Rm62 - aub

iclip, partial RNA sequence identification

(Ma et al., 2017)

protein-protein

Physical Interaction

Assay

References

pull down, autoradiography

(Boeke et al., 2011)

Rm62 - AGO2

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Lee et al., 2018, Ishizuka et al., 2002)

Rm62 - Cp190

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Moshkovich et al., 2011, Lei and Corces, 2006)

Rm62 - Dsp1

cosedimentation through density gradient, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, anti tag coimmunoprecipitation

(Lamiable et al., 2010)

Rm62 - Fmr1

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, autoradiography, anti tag western blot

(Lee et al., 2018, Ishizuka et al., 2002)

Rm62 - Mettl3

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2021)

Rm62 - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - Pten

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - Pur-α

pull down, western blot, autoradiography, Identification by mass spectrometry

(Qurashi et al., 2011)

Rm62 - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - SmD1

anti tag coimmunoprecipitation, anti tag western blot

(Xiong et al., 2013)

Rm62 - Su(var)3-9

pull down, autoradiography, anti bait coimmunoprecipitation, anti tag western blot, affinity chromatography technology, Identification by mass spectrometry

(Boeke et al., 2011)

Rm62 - Tdrd3

coimmunoprecipitation, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Lee et al., 2018)

Rm62 - Thor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - Top3β

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Lee et al., 2018)

Rm62 - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - Zrf1

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot, anti tag western blot

(Shun Li et al., 2025)

Rm62 - dachs

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Rm62 - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - melt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Rm62 - nito

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2021)

Rm62 - vas

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Durdevic and Ephrussi, 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Schneiderman et al., 2010)

Fmr1

suppressible

(Cziko et al., 2009)

enhanceable

(Lamiable et al., 2010)

enhanceable

(Csink, 1997.12.9, Csink et al., 1994)

suppressible