FB2022_02, released March 29, 2022

Gene: Dmel\sesB

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General Information
Symbol
Dmel\sesB
Species
D. melanogaster
Name
stress-sensitive B
Annotation Symbol
CG16944
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003360
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). (UniProt, Q26365)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ANT, jive, A/A-T/sesB, ses B, Adenine nucleotide translocase

Key Links
Genomic Location
Cytogenetic map
9E10-9F1
Sequence location
Recombination map
1-32
RefSeq locus
NC_004354 REGION:10780893..10786958
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables ATP:ADP antiporter activity
inferred from mutant phenotype
(Rikhy et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables ATP:ADP antiporter activity
inferred from biological aspect of ancestor with PANTHER:PTN002900428
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (19 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
involved_in action potential
inferred from direct assay
(Trotta et al., 2004)
involved_in cellular response to oxidative stress
inferred from mutant phenotype
(Terhzaz et al., 2010)
involved_in chemical synaptic transmission
inferred from direct assay
(Trotta et al., 2004)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Celotto et al., 2006)
involved_in locomotion
inferred from mutant phenotype
(Celotto et al., 2006)
involved_in mitochondrial calcium ion homeostasis
inferred from mutant phenotype
(Terhzaz et al., 2010)
involved_in mitochondrial transport
inferred from mutant phenotype
(assigned by UniProt )
(Hutter and Karch, 1994)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Celotto et al., 2006)
involved_in negative regulation of autophagy
inferred from direct assay
(DeVorkin et al., 2014)
involved_in neuron cellular homeostasis
inferred from mutant phenotype
(Celotto et al., 2006)
involved_in oogenesis
inferred from mutant phenotype
(DeVorkin et al., 2014)
involved_in positive regulation of ATP biosynthetic process
inferred from mutant phenotype
(Vartiainen et al., 2014)
involved_in regulation of cytosolic calcium ion concentration
inferred from mutant phenotype
(Terhzaz et al., 2010)
involved_in regulation of mitochondrial depolarization
inferred from mutant phenotype
(Kim et al., 2007)
involved_in synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Trotta et al., 2004)
involved_in synaptic vesicle transport
inferred from direct assay
(Trotta et al., 2004)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in mitochondrial ADP transmembrane transport
inferred from electronic annotation with InterPro:IPR002113
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in mitochondrial ATP transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN008143655
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN008143655
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from direct assay
(assigned by UniProt )
(Hutter and Karch, 1994)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009)
inferred from direct assay
(Terhzaz et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrial inner membrane
inferred from biological aspect of ancestor with PANTHER:PTN001183263
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the mitochondrial carrier (TC 2.A.29) family. (Q26365)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS -
The solute carrier family 25 (SLC25) or mitochondrial carrier family (MCF) members shuttle metabolites, nucleotides and cofactors across the inner mitochondrial membrane. (Adapted from FBrf0212481, FBrf0212949 and PMID:23266187).
Protein Function (UniProtKB)
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
(UniProt, Q26365)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
sesB (J.C. Hall)
sesB1 causes adults to be extremely sensitive to mechanical shock (Homyk and Sheppard, 1977); paralysis lasts many seconds, and recovery is slow; the mutant is also generally inactive and uncoordinated; when stimulated to jump and fly, does so abnormally for short distances; when reared at 29, after being raised at 22, sesB2 is not only stress-sensitive, but it also becomes debilitated after several bouts of induced to hopping and flying; in addition, sesB2 is heat sensitive for female sterility (after rearing at low temperature).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\sesB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q26365)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.46

Shares 5' UTR with downstream gene.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sesB-RA
FBtr0073421
NM_078554
1634
299
sesB-RB
FBtr0073423
NM_167248
1640
299
sesB-RC
FBtr0073422
NM_167246
1747
312
sesB-RD
FBtr0073424
NM_167247
1853
312
sesB-RE
FBtr0346384
NM_001298161
1685
299
Additional Transcript Data and Comments
Reported size (kB)

1.6, 1.2 (northern blot)

(Zhang et al., 1999)

1.85, 1.1 (northern blot)

(Louvi and Tsitilou, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
sesB-PA
FBpp0073277
32.9
299
10.28
NP_511109
AAG22341
sesB-PB
FBpp0073279
32.9
299
10.28
NP_727450
AAF47957
sesB-PC
FBpp0073278
34.2
312
10.33
NP_727448
AAN09267
sesB-PD
FBpp0073280
34.2
312
10.33
NP_727449
AAN09268
sesB-PE
FBpp0312078
32.9
299
10.28
NP_001285090
AHN59560
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

299 aa isoforms: sesB-PA, sesB-PB, sesB-PE
312 aa isoforms: sesB-PC, sesB-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

299 (aa)

(Zhang et al., 1999)

297 (aa)

(Louvi and Tsitilou, 1992)
Comments
External Data
Domain

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

(UniProt, Q26365)
Subunit Structure (UniProtKB)

Monomer.

(UniProt, Q26365)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sesB using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 17
organism
(Louvi and Tsitilou, 1992)
adult stage
(Zhang et al., 1999)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
testis
(Terhzaz et al., 2010)
adult midgut
(Terhzaz et al., 2010)
adult head
(Terhzaz et al., 2010)
ovary
(Terhzaz et al., 2010)
Additional Descriptive Data

Isoform-specific expression of sesB was observed. The shorter isoform (sesB-PA, sesB-PB, and sesB-PE) is detected in testis, midgut, head, and ovary by RT-PCR. The longer isoform (sesB-PC and sesB-PD) is not detected in Malphigian tubules and is almost specific to ovary.

(Terhzaz et al., 2010)

sesB transcripts are detected in adult RNA on northern blots.

(Zhang et al., 1999)

Both sesB transcripts are detected in RNA from Kc cells and 8-24 hr embryos.

(Louvi and Tsitilou, 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult main segment of Malpighian tubule
(Terhzaz et al., 2010)
adult Malpighian tubule principal cell
(Terhzaz et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

sesB localizes to mitochondria in Malpighian tubule principal cells.

(Terhzaz et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from direct assay
(assigned by UniProt )
(Hutter and Karch, 1994)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009)
inferred from direct assay
(Terhzaz et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sesB in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sesB
Transgenic constructs containing regulatory region of sesB
Aberrations (Deficiencies and Duplications) ( 62 )
Inferred from experimentation ( 62 )
Gene disrupted in
Df(1)59D3
(Zhimulev et al., 1987)
Df(1)203C10
(Zhimulev et al., 1987)
Df(1)B13
(Barbash et al., 2000, Zhang et al., 1999)
Df(1)CH6
(Barbash et al., 2000, Zhang et al., 1999)
Df(1)HC133
(Barbash et al., 2000, Zhang et al., 1999, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)ras59
(Zhang et al., 1999, Janca et al., 1986)
Df(1)ras203
(Barbash et al., 2000, Zhang et al., 1999, Janca et al., 1986, Nash and Janca, 1983)
Df(1)ras217
(Janca et al., 1986)
Df(1)ras-P14
(Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)
Df(1)ras-v17
(Barbash et al., 2000, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)ras-v-P26
(Zhimulev et al., 1987)
Df(1)sbr1
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sbr8
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sbr9
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)sbr10
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v64f
(Barbash et al., 2000, Zhang et al., 1999, Zhimulev et al., 1987, Janca et al., 1986, Zhimulev, 1982, Zhimulev et al., 1981)
Df(1)v-B151
(Zhimulev et al., 1987)
Df(1)v-L3
(Rikhy et al., 2003)
Df(1)v-L7
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L11
(Barbash et al., 2000, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L15
(Rikhy et al., 2003, Barbash et al., 2000, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M1
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M7
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-P5
(Zhimulev et al., 1987, Zhimulev et al., 1981)
In(1)sesB3
(Janca et al., 1986)
In(1)sesB9Ed-6
(Janca et al., 1986)
Gene duplicated in
Dp(1;2)v+63i
(Rikhy et al., 2003, Barbash et al., 2000, Zhang et al., 1999, Zhimulev et al., 1987, Nash and Janca, 1983, Lefevre, 1981, Zhimulev et al., 1981)
Dp(1;2)v+65b
(Lefevre, 1981)
Dp(1;2)v+75d
(Barbash et al., 2000, Zhang et al., 1999)
Dp(1;3)v+74c
(Zhang et al., 1999)
Gene not disrupted in
Df(1)C52
(Barbash et al., 2000)
Df(1)C128
(Rikhy et al., 2003)
Df(1)C246
(Rikhy et al., 2003)
Df(1)ct4b1
(Rikhy et al., 2003)
Df(1)HA92
(Rikhy et al., 2003)
Df(1)KA7
(Rikhy et al., 2003, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)lz-90b24
(Rikhy et al., 2003)
Df(1)N71
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)N105
(Rikhy et al., 2003)
Df(1)N110
(Barbash et al., 2000, Zhang et al., 1999)
Df(1)RA2
(Rikhy et al., 2003)
Df(1)RA37
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)ras-TM5
(Zhang et al., 1999)
Df(1)ras-TM6
(Zhang et al., 1999)
Df(1)RJ7
(Barbash et al., 2000, Zhang et al., 1999)
Df(1)v65b
(Zhimulev et al., 1981)
Df(1)v-L1
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L2
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L3
(Zhang et al., 1999, Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-L4
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M5
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-M6
(Zhimulev et al., 1987, Zhimulev et al., 1981)
Df(1)v-N48
(Zhang et al., 1999)
Df(1)v-P16
(Zhimulev et al., 1987)
Df(1)v-P22
(Zhimulev et al., 1987)
In(1)AB
(Zhang et al., 1997)
In(1)AC2LABR
(Barbash et al., 2000, Zhang et al., 1999)
T(1;2)ras-TM3
(Zhang et al., 1999)
Gene not duplicated in
Dp(1;2)v+65b
(Zhimulev et al., 1987)
Dp(1;Y)dsh+y+
(Zhimulev et al., 1987)
Dp(1;Y)v+y+366
(Zhimulev et al., 1987)
Dp(1;Y)v+y+
(Zhang et al., 1999, Zhimulev et al., 1987, Zhimulev et al., 1981)
Dp(1;Y)v+y+U15
(Zhimulev et al., 1987)
In(1)ABLAC2R
(Zhang et al., 1999)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | cold sensitive
lethal | female | recessive
lethal | heat sensitive
lethal | male
lethal | maternal effect
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of second instar larval stage, with Scer\GAL4Act5C.PI
lethal - all die during embryonic stage | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal | female
partially lethal | male
partially lethal - majority die
partially lethal - majority die (with Df(1)v-L15)
partially lethal - majority die (with sesB1)
partially lethal - majority die (with sesB9Ed-1)
partially lethal - majority die (with sesB9Ed-2)
partially lethal - majority die (with sesB9Ed-3)
partially lethal - majority die (with sesB9Ed-5)
partially lethal - majority die (with sesB9Ed-6)
partially lethal - majority die (with sesBG0386)
partially lethal - majority die (with sesBorg)
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | recessive
viable
viable, with Scer\GAL4tin.CΔ4
viable (with sesB9Ed-4)
viable (with sesBorg)
viable | male
Sterility
Allele
female sterile
female sterile | heat sensitive
fertile
Other Phenotypes
Allele
abnormal auditory perception
abnormal behavior | recessive
abnormal courtship behavior | male limited
abnormal developmental rate
abnormal locomotor behavior
abnormal neuroanatomy
abnormal neurophysiology
abnormal neurophysiology | heat sensitive
abnormal oxidative stress response, with Scer\GAL4c42
abnormal oxidative stress response, with Scer\GAL4hs.PB
abnormal oxidative stress response, with Scer\GAL4Uro.PT
bang sensitive
decreased cell number | adult stage, with Scer\GAL4ey.PU
flightless (with Df(1)v-L15)
hypoactive
increased cell death, with Scer\GAL4GMR.PS
majority die during embryonic stage
paralytic
paralytic | conditional
paralytic | heat sensitive (with Df(1)v-L15)
paralytic | heat sensitive (with sesBG0386)
paralytic | heat sensitive (with sesBorg)
paralytic | recessive | heat sensitive
short lived
short lived | male limited
some die during embryonic stage | recessive
some die during larval stage | recessive
some die during pharate adult stage | recessive
some die during pupal stage, with Scer\GAL4Act5C.PI
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during second instar larval stage, with Scer\GAL4Act5C.PI
visible, with Scer\GAL4pnr-MD237
visible | recessive | somatic clone
wild-type
Phenotype manifest in
Allele
adult ventral nerve cord
egg chamber | germline clone | maternal effect
egg chamber | nutrition conditional
embryonic/larval Malpighian tubule, with Scer\GAL4c42
embryonic/larval Malpighian tubule, with Scer\GAL4c710
embryonic/larval Malpighian tubule, with Scer\GAL4hs.PB
embryonic/larval Malpighian tubule, with Scer\GAL4Uro.PT
eye, with Scer\GAL4ey.PU
eye | somatic clone
eye disc | third instar larval stage
flight muscle cell
Malpighian tubule
mesothoracic tergum, with Scer\GAL4pnr-MD237
mitochondrial membrane | third instar larval stage, with Scer\GAL4GMR.PS
mitochondrion
mitochondrion | larval stage, with Scer\GAL4c42
mitochondrion | larval stage, with Scer\GAL4c710
mitochondrion | larval stage, with Scer\GAL4hs.PB
mitochondrion | larval stage, with Scer\GAL4Uro.PT
neuromuscular junction
NMJ bouton | increased number
ovariole | germline clone
sarcomere, with Scer\GAL4Mef2.PR
trichogen cell, with Scer\GAL4pnr-MD237
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC25A4
12 of 15
Yes
Yes
1  
Hsap\SLC25A5
10 of 15
No
Yes
2  
Hsap\SLC25A6
9 of 15
No
Yes
2  
Hsap\SLC25A31
8 of 15
No
Yes
Hsap\IFNG
1 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc25a4
12 of 15
Yes
Yes
Mmus\Slc25a5
10 of 15
No
Yes
Mmus\Slc25a31
7 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Slc25a4
11 of 13
Yes
Yes
Rnor\Slc25a5
9 of 13
No
Yes
Rnor\Slc25a31
6 of 13
No
Yes
Rnor\LOC100909799
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\slc25a4
11 of 12
Yes
Yes
Xtro\slc25a5
9 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\slc25a4
12 of 15
Yes
Yes
Drer\slc25a5
10 of 15
No
Yes
Drer\slc25a6
10 of 15
No
Yes
Drer\si:dkey-251i10.1
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\ant-1.3
12 of 15
Yes
No
Cele\ant-1.4
12 of 15
Yes
No
Cele\ant-1.2
11 of 15
No
No
Cele\ant-1.1
10 of 15
No
No
Cele\R07E3.4
6 of 15
No
Yes
Cele\F25B4.7
5 of 15
No
Yes
Cele\C47E12.2
4 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\AAC1
8 of 9
Yes
Yes
Atha\AAC2
8 of 9
Yes
Yes
Atha\AAC3
8 of 9
Yes
Yes
Atha\ER-ANT1
7 of 9
No
Yes
Atha\PM-ANT
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\AAC3
12 of 15
Yes
Yes
Scer\PET9
11 of 15
No
Yes
Scer\AAC1
10 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\anc1
10 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (43)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ant2
9 of 10
aralar1
1 of 10
Bmcp
1 of 10
CG1628
1 of 10
CG1907
1 of 10
CG2616
1 of 10
CG4743
1 of 10
CG4995
1 of 10
CG5254
1 of 10
CG5805
1 of 10
CG6893
1 of 10
CG7514
1 of 10
CG7943
1 of 10
CG8026
1 of 10
CG8323
1 of 10
CG9582
1 of 10
CG16736
1 of 10
CG18324
1 of 10
CG18327
1 of 10
CG18418
1 of 10
colt
1 of 10
Dic1
1 of 10
Dic2
1 of 10
Dic3
1 of 10
Dic4
1 of 10
DPCoAC
1 of 10
GC1
1 of 10
GC2
1 of 10
mfrn
1 of 10
MME1
1 of 10
Mpcp1
1 of 10
Mpcp2
1 of 10
PMP34
1 of 10
Rim2
1 of 10
SCaMC
1 of 10
sea
1 of 10
Shawn
1 of 10
Tpc1
1 of 10
Tpc2
1 of 10
Tyler
1 of 10
Ucp4A
1 of 10
Ucp4B
1 of 10
Ucp4C
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SLC25A4; solute carrier family 25 member 4
12 of 15
103220
 
SLC25A5; solute carrier family 25 member 5
10 of 15
300150
       
      SLC25A6; solute carrier family 25 member 6
      9 of 15
      300151, 403000
           
          SLC25A31; solute carrier family 25 member 31
          8 of 15
          610796
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              sesB
              suppressible
              Atpα
              (Trotta et al., 2004)
              sesB
              enhanceable
              awd
              (Rikhy et al., 2003)
              sesB
              enhanceable
              mt:ATPase6
              (Celotto et al., 2006)
              sesB
              suppressible
              para
              (Trotta et al., 2004)
              sesB
              enhanceable
              shi
              (Trotta et al., 2004)
              sesB
              suppressible
              srl
              (Vartiainen et al., 2014)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Atpα
              suppressible
              sesB
              (Trotta et al., 2004)
              Dcp-1
              suppressible
              sesB
              (DeVorkin et al., 2014)
              mt:ATPase6
              enhanceable
              sesB
              (Celotto et al., 2006)
              shi
              enhanceable
              sesB
              (Rikhy et al., 2003)
              External Data
              Subunit Structure (UniProtKB)
              Monomer.
              (UniProt, Q26365 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              X
              Recombination map
              1-32
              Cytogenetic map
              9E10-9F1
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              9E10-9F1
              Limits computationally determined from genome sequence between P{EP}Atg8aEP362&P{EP}CG1826EP1098 and P{EP}sesBEP319&P{EP}ImpEP760
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              9F-9F
              (determined by in situ hybridisation) 9E7--8 (determined by in situ hybridisation) 9F1--2 (determined by in situ hybridisation)
              (Peter et al., 2002)
              9F-9F
              (determined by in situ hybridisation) 9E7--8 (determined by in situ hybridisation) 9F1--2 (determined by in situ hybridisation) 9E4--8 (determined by in situ hybridisation)
              (Schäfer et al., 1999.12.2)
              9E6-9E6
              (Hutter, 1994.10.27)
              9E7-9E8
              (Zhang et al., 1997)
              9E-9E
              (determined by in situ hybridisation)
              (Louvi and Tsitilou, 1992)
              Immediately proximal to the distal breakpoint of In(1)AB.
              (Zhang et al., 1997)
              Experimentally Determined Recombination Data
              Location

              1-32

              (FlyBase, 2016)

              1-33.7

              (Comeron et al., 2012)

              1-

              (Rikhy et al., 2003)

              1-32.4

              Left of (cM)
              (Rikhy et al., 2003)
              Right of (cM)
              (Rikhy et al., 2003)
              Notes

              Mapped by Homyk.

              Stocks and Reagents
              Stocks (20)
              Genomic Clones (7)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (628)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Shiomi et al., 2021, Terhzaz et al., 2010)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: sesB CG16944

              (Wang, 1999.11)

              Source for identity of: sesB orangi

              (Rikhy, 2001.3.7)
              Source for database merge of

              Source for merge of: sesB anon-WO02059370.55

              (FlyBase, 1996-)
              Additional comments

              The genes sesB and Ant2 share >70% identity and close proximity, and so may have been derived from a DNA-based tandem duplication.

              (Langille and Clark, 2007)

              Source for merge of sesB anon-WO02059370.55 was sequence comparison ( date:051113 ).

              (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

              "l(1)G0083" may affect "Ant2" and/or "sesB".

              (Peter et al., 2002)

              sesB and Ant2 do not correspond to Hmr.

              (Zhang et al., 1999)

              Lack of complementation of lethal alleles and sesB alleles reported by Zhimulev et al. (FBrf0045718). Janca et al. (FBrf0044450) report lack of full complementation between sesB3 and sesB alleles.

              (Zhang et al., 1997)
              Other Comments

              sesB is a negative regulator of starvation-induced autophagic flux during oogenesis.

              (DeVorkin et al., 2014)

              Identification: as a modifier of a temperature-sensitive paralytic mutation of shi.

              (Rikhy et al., 2001)

              sesB mutants enhance the temperature sensitive paralytic defect in shi mutants.

              (Rikhy et al., 2001)

              The adjacent genes sesB and Ant2, which encode adenine nucleotide translocases, are transcribed from a common promoter and their mRNAs are produced by differential splicing of a dicistronic primary transcript. Overall orientation not stated: Ant2+ = sesB+ Ant2+

              (Zhang et al., 1999)

              Encodes the Adenine nucleotide (ADP/ATP) translocase of the inner mitochondrial membrane.

              (Zhang et al., 1997)

              Most mutant alleles are lethal, but some show a stress-sensitive paralytic phenotype.

              (Zhang et al., 1997)

              Claimed that Hmr encodes the adenine nucleotide translocase, but this is in error.

              (Hutter and Karch, 1994)
              Origin and Etymology
              Discoverer

              Homyk.

              Etymology
              Identification
              External Crossreferences and Linkouts ( 75 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (38)
              Reported As
              Symbol Synonym
              A/A-T
              A/A-T/sesB
              (Comeron and Kreitman, 1998, Zeng et al., 1998)
              ADP/ATP translocase
              (Louvi, 1992.11.3)
              ADT2
              (Mushegian et al., 1998)
              ANT
              (Vartiainen et al., 2014, Kim et al., 2007, Chang and Min, 2005)
              ANT1
              (Terhzaz et al., 2010)
              CG16944
              (Curcio et al., 2020, Kolkhof et al., 2017, Çiçek et al., 2016, Choo et al., 2015, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Mosallanejad et al., 2010, Müller et al., 2010, Keleman et al., 2009.8.5, Mohammad et al., 2009, Chen et al., 2008, Ni et al., 2008, Cermelli et al., 2006, Bourbon et al., 2002, Fulton et al., 2001, Rikhy, 2001.3.7)
              EM12
              (Lefevre, 1981)
              Hmr
              (Hutter, 1994.10.27)
              S12
              (Lefevre and Watkins, 1986, Lefevre, 1981)
              SESB
              (Shiomi et al., 2021)
              SesB
              (Curcio et al., 2020, Hope et al., 2020, Ji et al., 2017, Kolkhof et al., 2017, Martinez et al., 2017, Terhzaz et al., 2010)
              anon-WO02059370.55
              dANT
              (Kim et al., 2007)
              dSLC25A4
              (Gokhale et al., 2019)
              jive
              (Guan et al., 2011, Guan et al., 2005)
              l(1)9Ed
              l(1)9Fa
              l(1)DC701
              l(1)EM31
              l(1)G0126
              l(1)G0247
              l(1)G0386
              l(1)S12
              (Zhimulev et al., 1987, Zhimulev et al., 1981)
              orangi
              (Rikhy et al., 2001)
              ses B
              (Reynolds, 2018, Reynolds et al., 2003)
              sesB
              (Pang et al., 2021, Aboukilila et al., 2020, Kanellopoulos et al., 2020, Weiner et al., 2020, Gokhale et al., 2019, Zirin et al., 2019, Johan Arief et al., 2018, Liu et al., 2018, Markantone et al., 2018, Li et al., 2017, Transgenic RNAi Project members, 2017-, Fogle et al., 2016, Nakazawa et al., 2016, Ribeiro et al., 2016, Zhang et al., 2016, Chen et al., 2015, Choo et al., 2015, Dent et al., 2015, Foriel et al., 2015, Kroll et al., 2015, Li et al., 2015, Lucey et al., 2015, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, DeVorkin et al., 2014, Vartiainen et al., 2014, Kwon et al., 2013, Sen et al., 2013, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Brooks et al., 2011, Friedman et al., 2011, Ren et al., 2011, Müller et al., 2010, Terhzaz et al., 2010, Tan et al., 2009, Boylan et al., 2008, Chen et al., 2008, Fergestad et al., 2008, Hutter, 2007, Kim et al., 2007, Langille and Clark, 2007, Rikhy et al., 2007, Stuart et al., 2007, Toivonen et al., 2007, Bartolome and Charlesworth, 2006, Beller et al., 2006, Celotto et al., 2006, Cermelli et al., 2006, Dorus et al., 2006, Dorus et al., 2006, Fergestad et al., 2006, Munro et al., 2006, Brand et al., 2005, Chang and Min, 2005, Guan et al., 2005, Trotta et al., 2004)
              sesb
              (Liu and Secombe, 2015)
              Name Synonyms
              ADP,ATP carrier protein
              (Pflieger et al., 2008)
              Adenine nucleotide translocase
              (Kim et al., 2007)
              Drosophila ANT
              (Kim et al., 2007)
              Stress sensitive B
              (Johan Arief et al., 2018)
              Stress-sensitive B
              (Urban et al., 2017, Pedersen et al., 2010, Manh et al., 2005)
              adenine nuclear translocase
              (Vartiainen et al., 2014)
              lethal(1)9Ed
              stress sensitive B
              (Sen et al., 2013, Chen et al., 2008, Cermelli et al., 2006)
              stress-sensitive
              (Kroll et al., 2015)
              stress-sensitive B
              (Sen and Cox, 2016, Sen et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Fergestad et al., 2008, Brand et al., 2005, Trotta et al., 2004)
              Secondary FlyBase IDs
              • FBgn0001474
              • FBgn0001601
              • FBgn0001665
              • FBgn0005428
              • FBgn0005676
              • FBgn0027300
              • FBgn0028338
              • FBgn0040166
              • FBgn0064129
              • FBgn0066004
              Datasets (8)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (8)
              Result
              Result Type
              Title
              scRNAseq_2020_Cattenoz_NI_seq_clustering
              Clustering analysis of hemocytes from non-infested third instar larvae
              scRNAseq_2020_Cattenoz_WI_seq_clustering
              Clustering analysis of hemocytes from wasp-infested third instar larvae
              scRNAseq_2020_Cho_NI72LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
              scRNAseq_2020_Cho_NI96LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI120LG_seq_clustering
              Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
              scRNAseq_2020_Cho_WI96LG_seq_clustering
              Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI96HL_seq_clustering
              Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
              scRNAseq_2020_Cho_NI120HL_seq_clustering
              Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
              References (181)