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General Information
Symbol
Dmel\shg
Species
D. melanogaster
Name
shotgun
Annotation Symbol
CG3722
Feature Type
FlyBase ID
FBgn0003391
Gene Model Status
Stock Availability
Gene Snapshot
Also Known As

DE-cadherin, E-cadherin, DE-cad, E-cad, Ecad

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:21,049,654..21,057,197 [-]
Recombination map

2-92

RefSeq locus
NT_033778 REGION:21049654..21057197
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (58 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Myo10A; FB:FBgn0263705
inferred from physical interaction with FLYBASE:N; FB:FBgn0004647
Terms Based on Predictions or Assertions (0 terms)
Biological Process (45 terms)
Terms Based on Experimental Evidence (44 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:p120ctn; FB:FBgn0260799
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:foi; FB:FBgn0024236
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:RhoL; FB:FBgn0014380
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001931898
(assigned by GO_Central )
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
Protein Function (UniProtKB)
Cadherins are calcium-dependent cell adhesion proteins (PubMed:7958432). In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:7958432). During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte (PubMed:24855950, PubMed:30763317). Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surrounding nurse cells (PubMed:24855950). This adhesion increases Rac1 signaling in the leading cells, which in turn stabilizes DE-cadherin/DE-cadherin adhesions through the formation of forward-directed protrusions which attach/detach to the surrounding nurse cells in order to pull the cluster through the egg chamber to the oocyte (PubMed:24855950). Within the BC cluster, also promotes adhesion between BCs, and between BCs and polar cells which enables the lead BC to communicate direction to the other cells in the cluster, providing polarity to each individual cell and ensuring collective behavior (PubMed:24855950, PubMed:30763317). May function in cell intercalation in the lateral epidermis during germband extension (PubMed:24681004). Contributes to the determination of body left-right asymmetry by enhancing Myo31DF activity and inhibiting Myo61F activity (PubMed:22491943).
(UniProt, Q24298)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
shg: shotgun
Embryonic lethal. Embryonic cuticle has many small holes with necrotic rims. Head grossly distorted. Weak alleles show head defects and irregular flaws in segmentation pattern.
Summary (Interactive Fly)

cadherin - regulates cell aggregation preventing mixing of cells at tissue boundaries - Neuroblast niche position is controlled by PI3-kinase dependent DE-Cadherin adhesion - required for the maintenance of ring canals anchoring to mechanically withstand tissue growth during oogenesis

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\shg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0071546
6400
1507
Additional Transcript Data and Comments
Reported size (kB)

5.4 (compiled cDNA)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0071475
169.8
1507
4.38
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

150 (kD observed)

1507 (aa); 150 (kD observed)

Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via cytoplasmic region) with Inx2 (via cytoplasmic loop) (PubMed:15047872). Interacts with Hakai (PubMed:19682089). Interacts with Myo31DF (PubMed:22491943).

(UniProt, Q24298)
Post Translational Modification

N-glycosylation is important for biosynthesis and function.

(UniProt, Q24298)
Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

(UniProt, Q24298)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\shg using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

ectoderm anlage

Comment: anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

labial sensory complex primordium

Comment: reported as labial complex specific anlage

maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

salivary gland body primordium

Comment: reported as salivary gland body specific anlage

salivary gland duct anlage

Comment: reported as salivary gland duct specific anlage

Additional Descriptive Data

shg is expressed in border follicle cells at oogenesis stage 9 before border cell migration. Expression shifts from an anterior band (centripetally migrating follicle cells) at stage S10A to strong expression in midline cells and weak expression in floor and roof cells at stage S10B. Expression continues in stages S11 and S12 in cells forming the dorsal anterior eggshell structures and in posterior follicle cells.

shg is detected throughout embryogenesis, in all epithelial tissues except for the mesoderm and posterior endoderm. shg expression decreases in neural precursors undergoing the epithelial-mesenchymal transition.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
tracheal fusion cell | vicinity of

Comment: between tracheal fusion cells

mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

shg protein is restricted to the apical portion of cell-cell contacts in ectodermal epithelia, in a region distinct from that of Fas3 protein (a marker for septate junction) localization.

In ocelli, shg is concentrated at the distal and proximal ends of rhabdomeres.

In stage 13 embryos shg is expressed in Malpighian tubule Type II (stellate) cells, particularly those that contact the tubule lumen but is lower than in the neighboring Malpighian tubule Type I (principal) cells. All Malpighian tubule Type II cells contact the luminal surface of the tubules in mid stage 14 and express high levels of shg as well as crb, baz, and dlg1.

At the early third instar, secondary axon tracts form bundles of 20 to 50 fibers traversing the cortex and reaching the cortex-neuropile boundary. All early fibers express shg. In later third instar larvae, these axon tracts have grown and matured and no longer express shg. Late born, immature fibers grow at the center of these tracts and these younger fibers express shg.

shg protein concentrates at hub cell junctions. It is expressed in cyst cells and strongly enriched in the hub.

shg protein is concentrated at the apical portion of cell-cell contacts in differentiated epithelial layers.

shg is expressed in the anterior cluster of somatic gonadal precursor cells in the stage 17 embryonic gonad. It is also expressed in the adult hub.

PPO1 protein is localized to maturing crystal cells in the lymph gland cortical zone.

shg is localized to the adherens junctions of the cell-cell interfaces of all cells of the retina.

In stage 13 embryos,shg protein expression is detected on the cell membrane of both somatic germline precursor cells as well as the germline cells in both males and females. This localization is concurrent with the processes of ensheathment and coalescence of the developing gonad. In stage 17 male embryos, shg protein is concentrated in the anterior of the gonad in the region corresponding to the testes hub.

shg protein was first observed along cell-cell boundaries at the cellular blastoderm stage. At germ band elongation, it is present homogeneously in the epidermal ectoderm of the embryo. shg protein expression persists in the ectodermal epithelia including the epidermis, salivary glands, Malpighian tubules, hindgut and tracheal system throughout embryogenesis.

Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{PZ}shg10469
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{shg-lacZ.1.3}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\shg in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 64 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 75 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of shg
Transgenic constructs containing regulatory region of shg
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
border follicle cell & filopodium | somatic clone
border follicle cell & filopodium | somatic clone | cell non-autonomous
cardioblast & adherens junction
denticle & embryonic epidermis | somatic clone, with Scer\GAL4αTub84B.PP
embryonic/first instar larval cuticle & embryonic head
embryonic epidermis & embryonic head
embryonic head & embryonic/first instar larval cuticle
embryonic trachea & cortical actin cytoskeleton
lamina cortex & satellite glial cell, with Scer\GAL4nrv2.PS
microchaeta & mesothoracic tergum, with Scer\GAL4pnr-MD237
microchaeta | supernumerary & mesothoracic tergum, with Scer\GAL4pnr-MD237
microtubule & adherens junction, with Scer\GAL4btl.PS
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
0  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
2 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (18)
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (2)
1 of 12
Yes
No
1 of 12
Yes
No
Danio rerio (Zebrafish) (7)
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
3 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900IG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00C0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00BF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (10)
3 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Allele
Disease
Interaction
References
DOES NOT ameliorate  cancer
model of  cancer
is NOT ameliorated by biUAS.cBa
is NOT ameliorated by biUAS.cPa
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
RNA-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts (via cytoplasmic region) with Inx2 (via cytoplasmic loop) (PubMed:15047872). Interacts with Hakai (PubMed:19682089). Interacts with Myo31DF (PubMed:22491943).
(UniProt, Q24298 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map

2-92

Cytogenetic map
Sequence location
2R:21,049,654..21,057,197 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
57B15-57B16
Limits computationally determined from genome sequence between P{EP}grauEP688&P{PZ}shg10469 and P{PZ}king-tubby02821&P{lacW}Xbp1k13803
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
57B13-57B14
(determined by in situ hybridisation)
57B-57B
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (35)
Genomic Clones (13)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (60)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    shg mutant border follicle cells display dynamic defects in direction sensing.

    shg is necessary for normal morphology of wing margin cells.

    The shg protein promotes ommatidial rotation.

    In RNAi-treated shg flies, cellularisation proceeds until the onset of gastrulation, where the epithelium collapses and becomes multilayered

    In sec5 mutant epithelial cells, lateral shg protein is not recycled to the adherens junctions but instead accumulates in recycling endosomes.

    Border cells do not migrate when border or nurse cells are mutant for shg. Oocyte mislocalisation is often observed when follicle or nurse cells are shg mutant. shg mutant clones lose epithelial integrity and sort away from wild-type cells to form a smooth interface.

    shg is required during embryonic development for both germ cell ensheathment and gonad compaction.

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    shg regulates several aspects of tracheal tube fusion.

    The interaction of shg with p120ctn is not required for shg function in vivo.

    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

    shg is required for normal development of the optic placode in embryos.

    Asymmetrically distributed shg may regulate the orientation of asymmetric cell division in the sensory organ lineage.

    shg is required for anchoring somatic stem cells to their niches in the ovary.

    Adhesion between opposing rows of cardioblasts is defective in shg mutant embryos, resulting in the absence of lumen formation.

    shg expression is required in border follicle cells and centripetal follicle cells as well as in germline cells for migration of the two groups of follicle cells during oogenesis.

    The PCCD domain of shg has a role in efficient recruitment to apical area of plasma membranes crucial for dynamic epithelial morphogenesis.

    shg mediates oocyte positioning within the follicle.

    shg is required for the close association of germ cells in the egg chamber and for cell migration. A shg/arm complex has multiple functions for the regulation of organised cell adhesion events.

    Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.

    The binding sites for shg and α-Cat are mapped on arm protein, these bind independently of each other to arm and binding of each is required for the function of adherens junctions.

    Yeast two-hybrid system and in vivo assays have identified a large region of arm, spanning six central arm repeats, that is required for shg binding, whereas only 41 amino acids of shg are sufficient for arm binding.

    Overexpression of full length or truncated shg phenocopies wg. This is achieved by titrating arm away from a signalling function in the wg pathway.

    esg positively regulates transcription of shg. Overexpression of shg rescues the defect in one of the fusion points in esg mutants, demonstrating an essential role of shg in target recognition and identifying esg as a key regulator of cell adhesion and motility in tracheal morphogenesis. shg has multiple roles during tracheal branch fusion, it is essential for the initial adhesion and expansion of the lumen.

    shg is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia.

    Zygotic shg expression is required for processes of dynamic epithelial cell rearrangement in the embryo.

    shg has been cloned and sequenced.

    Principal midgut epithelial cells required shg to assume a columnar epithelial morphology.

    The primary structure of shg reveals it belongs to the cadherin subfamily and has several distinctive features. Transfection assays demonstrate shg functions as a Ca2+-dependent cell aggregation factor.

    Phenotypic analysis of mutants suggests that shg functions to direct adhesion between midgut epithelial cells, and that this adhesion is independent of the adhesion between endoderm and visceral mesoderm.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 43 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (87)
    Reported As
    Symbol Synonym
    CadE
    DE-Cad
    (Bellec et al., 2018, Kullmann and Krahn, 2018, Chen et al., 2017, Hamada-Kawaguchi and Yamamoto, 2017, Romani et al., 2017, Iwanami et al., 2016, Dong et al., 2015, Houssin et al., 2015, Satoh et al., 2015, Tarayrah et al., 2015, Couturier et al., 2014, Hamada-Kawaguchi et al., 2014, Sitaram et al., 2014, Groth et al., 2013, Morante et al., 2013, Nakamura et al., 2013, Singh et al., 2013, Talamillo et al., 2013, Xin et al., 2013, Bosveld et al., 2012, Förster and Luschnig, 2012, Gomez et al., 2012, Guilgur et al., 2012, Jemc et al., 2012, Johnson et al., 2012, Monk et al., 2012, Sen et al., 2012, Spahn et al., 2012, Zhou and Hong, 2012, Benhra et al., 2011, Genevet and Tapon, 2011, Gervais and Casanova, 2011, Huang et al., 2011, Li et al., 2011, Taniguchi et al., 2011, Taniguchi et al., 2011, Bahri et al., 2010, Bulgakova et al., 2010, Cobreros-Reguera et al., 2010, David et al., 2010, Franz and Riechmann, 2010, Krahn et al., 2010, Maurel-Zaffran et al., 2010, Simone and DiNardo, 2010, Bertet et al., 2009, Huang et al., 2009, Ma et al., 2009, Rajan et al., 2009, Sheng et al., 2009, Wang and Kalderon, 2009, Warner and Longmore, 2009, Zartman et al., 2009, Cobreros et al., 2008, Fernandez-Minan et al., 2008, Johnson et al., 2008, Larson et al., 2008, Medioni et al., 2008, Pope and Harris, 2008, Seppa et al., 2008, Bastock and Strutt, 2007, Egger et al., 2007, Hayden et al., 2007, Ninov et al., 2007, Nishimura et al., 2007, Jaiswal et al., 2006, Janody and Treisman, 2006, Simoes et al., 2006, Fox et al., 2005, Goode et al., 2005, Gorfinkiel et al., 2005, Harris and Peifer, 2005, Jafar-Nejad et al., 2005, Somers and Chia, 2005, Vaccari et al., 2005, Wei et al., 2005, Harris and Peifer, 2004, Wei et al., 2004, Wu et al., 2004, Nam and Choi, 2003, Medina et al., 2002, Sang and Ready, 2002, Hong et al., 2001)
    DE-cad
    (Park et al., 2020, Sun et al., 2020, Zhang et al., 2020, Bajur et al., 2019, Wang et al., 2019, Ikawa and Sugimura, 2018, Yu et al., 2018, Flores-Benitez and Knust, 2015, Hosono et al., 2015, Shen et al., 2014, Chin and Mlodzik, 2013, Da Ros et al., 2013, Lerner et al., 2013, Osterfield et al., 2013, Satoh et al., 2013, Zhou and Luo, 2013, De Graeve et al., 2012, Jemc et al., 2012, Ji and Tulin, 2012, Lim et al., 2012, McKinley et al., 2012, Nfonsam et al., 2012, Yuan et al., 2012, Zhai et al., 2012, Chang et al., 2011, Höhne et al., 2011, Kulkarni et al., 2011, Morante et al., 2011, Sato et al., 2011, Sawyer et al., 2011, Sun et al., 2011, Takemura and Adachi-Yamada, 2011, Wang et al., 2011, Weyers et al., 2011, Yamada et al., 2011, Doronkin et al., 2010, Gandille et al., 2010, Goldbach et al., 2010, Hilgers et al., 2010, Ho et al., 2010, Krahn et al., 2010, Shao et al., 2010, Warner et al., 2010, Zimmerman et al., 2010, Courbard et al., 2009, Fung et al., 2009, Gao et al., 2009, Gates et al., 2009, Kessler and Müller, 2009, Martin et al., 2009, Maybeck and Röper, 2009, McGill et al., 2009, O'Keefe et al., 2009, Romani et al., 2009, Urbano et al., 2009, Woolworth et al., 2009, Bosveld et al., 2008, Denef et al., 2008, Fung et al., 2008, Homem and Peifer, 2008, Li et al., 2008, Shaye et al., 2008, Stevens et al., 2008, Araujo et al., 2007, Conder et al., 2007, Dyer et al., 2007, Gates et al., 2007, Harris and Peifer, 2007, Sakurai et al., 2007, Tian and Ten Hagen, 2007, Callejo et al., 2006, Laplante and Nilson, 2006, Mirkovic and Mlodzik, 2006, Ng et al., 2006, Siegrist and Doe, 2006, Beronja et al., 2005, Stramer et al., 2005, Tanaka et al., 2004, Hemphala et al., 2003, Schulte et al., 2003, McCartney et al., 2001, Tepass et al., 2001, Tanentzapf et al., 2000, Wang et al., 2000, Iwai et al., 1997, Woods et al., 1997)
    DECadh
    E-cad
    (Choubey et al., 2020, Greig and Bulgakova, 2020, Ngo et al., 2020, Ponte et al., 2020, Wang et al., 2020, Alégot et al., 2019, Balaji et al., 2019, Garcia De Las Bayonas et al., 2019, Li et al., 2019, Röper et al., 2018, Sui et al., 2018, Clément et al., 2017, Pinheiro et al., 2017, Teng et al., 2017, Zhai et al., 2017, Saadin and Starz-Gaiano, 2016, Soriano et al., 2016, Apitz and Salecker, 2015, Bambardekar et al., 2015, Cilla et al., 2015, de Madrid et al., 2015, Liu et al., 2015, Zobel et al., 2015, Carvalho et al., 2014, Ito et al., 2014, Bardet et al., 2013, Bulgakova et al., 2013, Das et al., 2013, Guillot and Lecuit, 2013, Levayer and Lecuit, 2013, Osterfield et al., 2013, Pancratov et al., 2013, Pan et al., 2013, Pirraglia et al., 2013, Truong Quang et al., 2013, Yu and Guan, 2013, Ambegaonkar et al., 2012, Ambegaonkar et al., 2012, Förster and Luschnig, 2012, Lee and Fischer, 2012, Muñoz-Soriano et al., 2012, Chen et al., 2011, Greenberg and Hatini, 2011, Levayer et al., 2011, Mao et al., 2011, Mirkovic et al., 2011, Rauskolb et al., 2011, Strutt et al., 2011, Xu et al., 2011, You et al., 2011, Zhang et al., 2011, Chen et al., 2010, Colosimo et al., 2010, Forster et al., 2010, Georgiou and Baum, 2010, Inaba et al., 2010, Murthy et al., 2010, Nelson et al., 2010, Rauzi et al., 2010, Reddy et al., 2010, Sorrosal et al., 2010, Zhang et al., 2010, Boyle and Berg, 2009, Chen et al., 2009, Chung et al., 2009, Hayashi et al., 2009, Swanson et al., 2009, Acar et al., 2008, Cavey et al., 2008, Georgiou et al., 2008, Jayaram et al., 2008, Lighthouse et al., 2008, Maeda et al., 2008, Matakatsu and Blair, 2008, Pirraglia and Myat, 2008, Santiago-Martínez et al., 2008, Schlichting and Dahmann, 2008, Shindo et al., 2008, Sokac and Wieschaus, 2008, Wu et al., 2007, Pilot, 2006, Pilot et al., 2006, Okajima et al., 2005, Prakash et al., 2005, Takahashi et al., 2005, Starz-Gaiano and Montell, 2004, Bilder et al., 2003, James et al., 2002)
    l(2)10469
    l(2)k03401
    l(2)k10220
    shg
    (Hoshika et al., 2020, Hung et al., 2020, Liu et al., 2020, Banerjee et al., 2019, Bangi et al., 2019, Brantley and Fuller, 2019, Drummond-Barbosa, 2019, Finegan et al., 2019, Hartenstein et al., 2019, Jain et al., 2019, Jiang et al., 2019, Kockel et al., 2019, Nelson et al., 2019, Raza et al., 2019, Schumacher, 2019, Story et al., 2019, Tsai and Galko, 2019, Valoskova et al., 2019, Yang et al., 2019, Zeledon et al., 2019, Bernard et al., 2018, Mortensen et al., 2018, Razzell et al., 2018, Sun and Stathopoulos, 2018, Toret et al., 2018, Tsuboi et al., 2018, Eder et al., 2017, Hao and Jin, 2017, Lai et al., 2017, Ma et al., 2017, Pinheiro et al., 2017, Rohde et al., 2017, Simões et al., 2017, Skeath et al., 2017, Aigouy and Le Bivic, 2016, Dollar et al., 2016, Jurado et al., 2016, Lee et al., 2016, Ma et al., 2016, Peters and Berg, 2016, Piegholdt et al., 2016, Campbell and Casanova, 2015, Doggett et al., 2015, Fu et al., 2015, Houssin et al., 2015, Hunter et al., 2015, Le Droguen et al., 2015, Liu et al., 2015, Martín-Bermudo et al., 2015, Sato et al., 2015, Sherrard and Fehon, 2015, Carvalho et al., 2014, Chandran et al., 2014, Fernández et al., 2014, Gao et al., 2014, Gold and Brand, 2014, Kim and Choe, 2014, Rorth, 2014.11.24, Rudrapatna et al., 2014, Tseng et al., 2014, Geisbrecht et al., 2013, Gunawan et al., 2013, Huelsmann et al., 2013, Muñoz-Soriano et al., 2013, Pirraglia et al., 2013, Sotillos et al., 2013, Wang et al., 2013, Atallah et al., 2012, Dupont et al., 2012, Förster and Luschnig, 2012, Japanese National Institute of Genetics, 2012.5.21, Jemc et al., 2012, Kucherenko et al., 2012, Marinari et al., 2012, Sano et al., 2012, Sen et al., 2012, Yang et al., 2012, Abreu-Blanco et al., 2011, Albrecht et al., 2011, Araújo and Casanova, 2011, Clark et al., 2011, Degennaro et al., 2011, Eliazer and Buszczak, 2011, Huang et al., 2011, Mateus and Martinez Arias, 2011, Mateus et al., 2011, Michel et al., 2011, Mirkovic et al., 2011, Ohsawa et al., 2011, Slováková and Carmena, 2011, Takemura and Adachi-Yamada, 2011, Taniguchi et al., 2011, Taniguchi et al., 2011, Weyers et al., 2011, Xu et al., 2011, Campbell et al., 2010, Cobreros-Reguera et al., 2010, Fang and Adler, 2010, Fernandes et al., 2010, Fichelson et al., 2010, Gandille et al., 2010, Haruta et al., 2010, Langer et al., 2010, Pirraglia et al., 2010, Renault et al., 2010, Shao et al., 2010, Siekhaus et al., 2010, Zimmerman et al., 2010, Aerts et al., 2009, Bischoff and Cseresnyés, 2009, Christensen et al., 2009.5.6, Genevet et al., 2009, Huang et al., 2009, Langton et al., 2009, Levis, 2009.3.18, Martin et al., 2009, O'Keefe et al., 2009, Roeth et al., 2009, Sawyer et al., 2009, Shen et al., 2009, Swanson et al., 2009, Warner and Longmore, 2009, Widmann and Dahmann, 2009, Zartman et al., 2009, Cavey et al., 2008, Christensen et al., 2008.4.15, Harris and Tepass, 2008, Jin et al., 2008, Jin et al., 2008, Kunwar et al., 2008, Larson et al., 2008, Liu et al., 2008, Maeda et al., 2008, Santiago-Martínez et al., 2008, Schlichting and Dahmann, 2008, Seppa et al., 2008, Shindo et al., 2008, Voog et al., 2008, Zmojdzian et al., 2008, Blankenship et al., 2007, Buszczak et al., 2007, Cordero et al., 2007, Corrigall et al., 2007, Fung et al., 2007, Gorfinkiel and Arias, 2007, Hackney et al., 2007, Hayden et al., 2007, Junion et al., 2007, Mathieu et al., 2007, Montrasio et al., 2007, Neuman-Silberberg, 2007, O'Keefe et al., 2007, Pan et al., 2007, Sasaki et al., 2007, Szafranski and Goode, 2007, Cela and Llimargas, 2006, Igaki et al., 2006, Jung et al., 2006, Le Bras and Van Doren, 2006, Lovegrove et al., 2006, Matakatsu and Blair, 2006, Mathews et al., 2006, McCaffrey et al., 2006, Mirkovic and Mlodzik, 2006, Pirraglia et al., 2006, Singh et al., 2006, Wang and Hartenstein, 2006, Wang et al., 2006, Becam et al., 2005, Fox et al., 2005, McEwen and Peifer, 2005, Pacquelet and Rorth, 2005, Prakash et al., 2005, Harris and Peifer, 2004, Pastor-Pareja et al., 2004, Iwai et al., 1997)
    Name Synonyms
    Cadherin-E
    D-Ecadherin
    DE-CADHERIN
    DE-Cadherin
    (Sreejith et al., 2019, Iwanami et al., 2016, Jurado et al., 2016, Gold and Brand, 2014, Firmino et al., 2013, Fuse et al., 2013, Groth et al., 2013, Quan et al., 2013, Guilgur et al., 2012, Spahn et al., 2012, Zhou and Hong, 2012, Ayyub, 2011, Degennaro et al., 2011, Gervais and Casanova, 2011, Huang et al., 2011, Johnson et al., 2011, Lee and Thomas, 2011, Mateus and Martinez Arias, 2011, Mateus et al., 2011, Meghana et al., 2011, Tjota et al., 2011, Bahri et al., 2010, Benhra et al., 2010, Bulchand et al., 2010, David et al., 2010, Fang and Adler, 2010, Maurel-Zaffran et al., 2010, Padash-Barmchi et al., 2010, Reim and Frasch, 2010, Simone and DiNardo, 2010, Tamori et al., 2010, Zeng et al., 2010, Hijazi et al., 2009, Hirano et al., 2009, Huang et al., 2009, Johnson and Cagan, 2009, Kim et al., 2009, Sheng et al., 2009, Wang and Kalderon, 2009, Yan et al., 2009, Llense and Martín-Blanco, 2008, Sato et al., 2008, Schotman et al., 2008, Seppa et al., 2008, Vied and Kalderon, 2008, Zimmerman et al., 2008, Ayyub and Rodrigues, 2007, Bastock and Strutt, 2007, Cordero et al., 2007, Gonzalez et al., 2007, Käfer et al., 2007, Menzel et al., 2007, Ninov et al., 2007, Nishimura et al., 2007, Rodrigues and Bach, 2007, Shcherbata et al., 2007, Djiane et al., 2006, Jaiswal et al., 2006, Laplante and Nilson, 2006, Murray et al., 2006, Nystul and Spradling, 2006, Hoehne et al., 2005, Wei et al., 2005, Schumacher et al., 2004, Wei et al., 2004, Wu and Beitel, 2004, Akong et al., 2003, Fabrizio et al., 2003, Sokol and Cooley, 2003, Akong et al., 2002, Emerson and Van Vactor, 2002, Jankovics et al., 2002, Lopez-Schier and St. Johnston, 2002, Patel and Van Vactor, 2002, Schober and Perrimon, 2002, Sanson et al., 1999, Zarnescu and Thomas, 1997, Grawe et al., 1996)
    DE-cadherin
    (Read, 2018, Yu et al., 2018, Curran et al., 2017, Qin et al., 2017, Inaki et al., 2016, Lee et al., 2016, Morin-Poulard et al., 2016, Nishiguchi et al., 2016, Dolezal et al., 2015, Escobar et al., 2015, Reilly et al., 2015, Verboon et al., 2015, Yu et al., 2015, Hamada-Kawaguchi et al., 2014, Mouri et al., 2014, Ocorr et al., 2014, Roy et al., 2014, Toret et al., 2014, Yashiro et al., 2014, Chin and Mlodzik, 2013, Desai et al., 2013, Giuliani et al., 2013, Ji et al., 2013, Li et al., 2013, Ile et al., 2012, Jemc et al., 2012, Ji and Tulin, 2012, Kametaka et al., 2012, Singh and Mlodzik, 2012, Yano et al., 2012, Abreu-Blanco et al., 2011, Benhra et al., 2011, Casper et al., 2011, Huang et al., 2011, Mukai et al., 2011, Royo et al., 2011, Sawyer et al., 2011, Sun et al., 2011, Takemura and Adachi-Yamada, 2011, Buchon et al., 2010, Cardona et al., 2010, Doronkin et al., 2010, Fang and Adler, 2010, Fernandes et al., 2010, Fichelson et al., 2010, Goldbach et al., 2010, Haruta et al., 2010, He et al., 2010, Hilgers et al., 2010, Ho et al., 2010, Ho et al., 2010, Krahn et al., 2010, Levine et al., 2010, Mukai et al., 2010, Neisch et al., 2010, Ninov et al., 2010, Pataki et al., 2010, Quinones et al., 2010, Renault et al., 2010, Sekyrova et al., 2010, Shen et al., 2010, Siekhaus et al., 2010, Tiklova et al., 2010, Tiklová et al., 2010, Ueyama et al., 2010, Warner et al., 2010, Zhang et al., 2010, Zimmerman et al., 2010, Abe et al., 2009, Boyle and Berg, 2009, Desai et al., 2009, Homem and Peifer, 2009, Issigonis et al., 2009, Jeon and Zinn, 2009, Kessler and Müller, 2009, Larsen et al., 2009, Massarwa et al., 2009, Roeth et al., 2009, Urbano et al., 2009, Warner and Longmore, 2009, Warner and Longmore, 2009, Widmann and Dahmann, 2009, Widmann and Dahmann, 2009, Woolworth et al., 2009, Yan et al., 2009, Bosveld et al., 2008, Bosveld et al., 2008, Dansereau and Lasko, 2008, Desai et al., 2008, Fung et al., 2008, Homem and Peifer, 2008, Kunwar et al., 2008, Larson et al., 2008, Li et al., 2008, Liu et al., 2008, Loer et al., 2008, Matakatsu and Blair, 2008, Medioni et al., 2008, Menzel et al., 2008, Rodriguez-Diaz et al., 2008, Rusan et al., 2008, Sarpal et al., 2008, Schlichting and Dahmann, 2008, Shen et al., 2008, Todi et al., 2008, Voog et al., 2008, Zartman et al., 2008, Zmojdzian et al., 2008, Berger et al., 2007, Blankenship et al., 2007, Chandraratna et al., 2007, Conder et al., 2007, Durupt et al., 2007, Fox and Peifer, 2007, Fung et al., 2007, Gunawardane et al., 2007, Hayden et al., 2007, Jiang et al., 2007, Levine et al., 2007, Levine et al., 2007, Li et al., 2007, Mandal et al., 2007, Mathieu et al., 2007, Menzel et al., 2007, Mitonaka et al., 2007, Romani et al., 2007, Sakurai et al., 2007, Sasamura et al., 2007, Song et al., 2007, Tanentzapf et al., 2007, Wu et al., 2007, Atkey et al., 2006, Bayraktar et al., 2006, Bloor, 2006, Brown et al., 2006, del Alamo and Mlodzik, 2006, Halbleib and Nelson, 2006, Laplante and Nilson, 2006, Lehmann et al., 2006, Lehmann et al., 2006, Mathews et al., 2006, Matusek et al., 2006, Mirkovic and Mlodzik, 2006, Niki et al., 2006, Nystul and Spradling, 2006, Pai et al., 2006, Pereanu and Hartenstein, 2006, Saito et al., 2006, Schlichting et al., 2006, Sese et al., 2006, Wang and Hartenstein, 2006, Wodarz et al., 2006, Bao and Cagan, 2005, Becam et al., 2005, Beronja et al., 2005, D'Alterio et al., 2005, Fox et al., 2005, Harris et al., 2005, Langevin et al., 2005, Oda et al., 2005, Ostrowski et al., 2005, Pacquelet and Rorth, 2005, Sinha et al., 2005, Xie et al., 2005, Bauer et al., 2004, Fuchs et al., 2004, Geisbrecht and Montell, 2004, Gooding et al., 2004, Harris et al., 2004, Hayashi and Carthew, 2004, Laplante and Nilson, 2004, Millo et al., 2004, Murthy and Schwarz, 2004, Olson and Blair, 2004, Pai and Lee, 2004, Pinheiro and Montell, 2004, Polesello and Payre, 2004, Wang et al., 2004, Wu et al., 2004, Abdelilah-Seyfried et al., 2003, Alls et al., 2003, Bauer et al., 2003, Doerflinger et al., 2003, Dumstrei et al., 2003, Dumstrei et al., 2003, Gaengel and Mlodzik, 2003, Godt and Tepass, 2003, Godt and Tepass, 2003, Gonzalez-Reyes, 2003, Gupta and Schupbach, 2003, Hartenstein et al., 2003, Hayashi et al., 2003, Hidalgo and ffrench-Constant, 2003, Humbert et al., 2003, Jekely and Rorth, 2003, Jenkins and Van Doren, 2003, Lin, 2003, Lopez-Schier, 2003, Marygold and Vincent, 2003, McDonald et al., 2003, Muller, 2003, Müller and Bossinger, 2003, Nassif et al., 2003, Pacquelet et al., 2003, Ribeiro et al., 2003, Uv et al., 2003, Vegh and Basler, 2003, Visnyei et al., 2003, Yamashita et al., 2003, Barth and Nelson, 2002, Besse et al., 2002, Bloor and Kiehart, 2002, Bokel and Brown, 2002, Fulga and Rorth, 2002, Ghiglione et al., 2002, Knox and Brown, 2002, Kolodziej and Lee, 2002, Martinek et al., 2002, Medina et al., 2002, Rorth, 2002, Song and Xie, 2002, Song et al., 2002, Tepass, 2002, Wedlich, 2002, Wodarz, 2002, Bellaiche et al., 2001, Braga and Harwood, 2001, Cox et al., 2001, Dobens and Raftery, 2001, Dobens et al., 2001, Huber et al., 2001, Jesse et al., 2001, Kataoka et al., 2001, Liu and Montell, 2001, McDonald and Montell, 2001, Myster et al., 2001, Nilson and Schupbach, 2001, Silver and Montell, 2001, Wang et al., 2001, Bai et al., 2000, Cox et al., 2000, Hunter and Wieschaus, 2000, Knoblich, 2000, McNeill, 2000, Muller, 2000, Myster et al., 2000, Rashbass and Skaer, 2000, Tepass et al., 2000, Wu and Maniatis, 2000, Yagi and Takeichi, 2000, Cavallo et al., 1999, Cox et al., 1999, Dubreuil and Grushko, 1999, Goto and Hayashi, 1999, Ikeya and Hayashi, 1999, Kataoka et al., 1999, Lee et al., 1999, Liu and Montell, 1999, Niewiadomska et al., 1999, Oda and Tsukita, 1999, Tepass, 1999, Thomas and Williams, 1999, Usui et al., 1999, van Eeden and St. Johnston, 1999, Zarnescu and Thomas, 1999, Zarnescu and Thomas, 1999, Dubreuil and Grushko, 1998, Godt and Tepass, 1998, Godt et al., 1998, Hayashi et al., 1998, Katsube et al., 1998, Oda et al., 1998, Pfaff, 1998, Tanaka-Matakatsu and Hayashi, 1998, Thomas et al., 1998, Verkhusha et al., 1998, Yanagawa et al., 1998, Iwai et al., 1997, Martinek and Gaul, 1997, Oda et al., 1997, Tanaka-Matakastu et al., 1997, Tepass, 1997, Yanagawa et al., 1997, Cox et al., 1996, Kraut and Campos-Ortega, 1996, Oda et al., 1996, Orsulic and Peifer, 1996, Takahashi et al., 1996, Tanaka-Matakatsu et al., 1996, Kirkpatrick and Peifer, 1995, Oda, 1994)
    DE-cadherin/Shotgun
    Drosophila epithelial cadherin
    Drosophila melanogaster epithelial (DE)-cadherin
    E-cadherin
    (Kelleher et al., 2020, Loerke and Blankenship, 2020, Chang et al., 2019, Zeledon et al., 2019, Kale et al., 2018, Razzell et al., 2018, Stuelten et al., 2018, Ahmad, 2017, Hayes and Solon, 2017, LeBlanc and Lehmann, 2017, Ma et al., 2017, McFaul and Fernandez-Gonzalez, 2017, Yamamoto et al., 2017, Anllo and Schüpbach, 2016, Ji and Tulin, 2016, Tseng et al., 2016, Bambardekar et al., 2015, Cao et al., 2015, Dorn and Dorn, 2015, Eikenes et al., 2015, Felix et al., 2015, Hunter et al., 2015, Monier et al., 2015, Reilly et al., 2015, Zobel et al., 2015, Carvalho et al., 2014, Simões et al., 2014, Tseng et al., 2014, Yatsenko et al., 2014, Antunes et al., 2013, Bulgakova et al., 2013, Chen et al., 2013, Chen et al., 2013, Das et al., 2013, Huelsmann et al., 2013, Lee et al., 2013, Mao et al., 2013, Muñoz-Soriano et al., 2013, Pan et al., 2013, Pepperl et al., 2013, Pirraglia et al., 2013, Salzmann et al., 2013, Sotillos et al., 2013, Wan et al., 2013, Wang et al., 2013, Zimmerman et al., 2013, Ambegaonkar et al., 2012, Aranjuez et al., 2012, Bulgakova et al., 2012, Capilla et al., 2012, Förster and Luschnig, 2012, Jemc et al., 2012, Lee and Fischer, 2012, Lim and Thiery, 2012, Marinari et al., 2012, Peng et al., 2012, Tamada et al., 2012, Tian et al., 2012, Abreu-Blanco et al., 2011, Charlton-Perkins et al., 2011, Cohen et al., 2011, Gemp et al., 2011, Muñoz-Descalzo et al., 2011, Rauskolb et al., 2011, Richter et al., 2011, Riedel et al., 2011, Sabino et al., 2011, Strutt et al., 2011, Taniguchi et al., 2011, Zheng et al., 2011, Chen et al., 2010, Cohen et al., 2010, Doronkin et al., 2010, Forster et al., 2010, Haglund et al., 2010, Hermle et al., 2010, Hughes et al., 2010, Inaba et al., 2010, Leatherman and Dinardo, 2010, Martin et al., 2010, Monastirioti et al., 2010, Morais-de-Sá et al., 2010, Murthy et al., 2010, Reddy et al., 2010, Simões et al., 2010, Singh et al., 2010, Staple et al., 2010, Tikhmyanova et al., 2010, Zhang et al., 2010, Bertet et al., 2009, Boyle and Berg, 2009, Butler et al., 2009, Classen et al., 2009, Demontis and Dahmann, 2009, Fernandez-Gonzalez et al., 2009, Genevet et al., 2009, Grillo-Hill and Wolff, 2009, Hsu and Drummond-Barbosa, 2009, Kaido et al., 2009, Kolahi et al., 2009, Langton et al., 2009, Li et al., 2009, Mao et al., 2009, Martin et al., 2009, Mavrakis et al., 2009, Rajan et al., 2009, Shen et al., 2009, Sheng et al., 2009, Siddall et al., 2009, Widmann and Dahmann, 2009, Yan et al., 2009, Babaoglan et al., 2008, Bulgakova et al., 2008, Cavey et al., 2008, DeFalco et al., 2008, Dos-Santos et al., 2008, Georgiou et al., 2008, Gonzalez et al., 2008, Hilgenfeldt et al., 2008, Jayaram et al., 2008, Johnson et al., 2008, Kakihara et al., 2008, Kunwar et al., 2008, Larson et al., 2008, Lighthouse et al., 2008, Maeda et al., 2008, Ma et al., 2008, McDonald et al., 2008, Rauzi et al., 2008, Schlichting and Dahmann, 2008, Shen et al., 2008, Shindo et al., 2008, Simcox et al., 2008, Sokac and Wieschaus, 2008, Somorjai and Martinez-Arias, 2008, Bogard et al., 2007, Fuller and Spradling, 2007, Gorfinkiel and Arias, 2007, Harris and Peifer, 2007, Hsouna et al., 2007, Käfer et al., 2007, Kondo et al., 2007, Lecuit and Le Goff, 2007, Lecuit et al., 2007, Nishimura et al., 2007, Orihara-Ono et al., 2007, Sasaki et al., 2007, Wada et al., 2007, Blankenship et al., 2006, Fehon, 2006, Hsouna and Hsu, 2006, Lovegrove et al., 2006, Maitra et al., 2006, Mao et al., 2006, Mathews et al., 2006, Montell, 2006, Ng et al., 2006, Payne and Braun, 2006, Pilot, 2006, Pilot et al., 2006, Pirraglia et al., 2006, Schulte et al., 2006, van IJzendoorn, 2006, Wood et al., 2006, Berg, 2005, Leptin, 2005, Lu and Bilder, 2005, Myat et al., 2005, Pilot et al., 2005, Prakash and Clandinin, 2005, Prakash et al., 2005, Sommer et al., 2005, Stramer et al., 2005, Yamashita et al., 2005, Bienz and Hamada, 2004, Cliffe et al., 2004, Gilboa and Lehmann, 2004, Hayashi and Carthew, 2004, Hipfner et al., 2004, Hoffmans and Basler, 2004, Huynh and St. Johnston, 2004, Lecuit, 2004, Narasimha and Brown, 2004, Schulz et al., 2004, Starz-Gaiano and Montell, 2004, Gonzalez-Gaitan, 2003, Hao et al., 2003, Lee et al., 2003, Lee et al., 2003, Lovegrove et al., 2003, Paul et al., 2003, Perez-Moreno et al., 2003, Rogers et al., 2003, Rogers et al., 2003, Shook and Keller, 2003, Speck et al., 2003, Wallenfang and Matunis, 2003, Arbeitman et al., 2002, Bienz, 2002, Geisbrecht and Montell, 2002, Grammont and Irvine, 2002, Hamada and Bienz, 2002, Ip and Gridley, 2002, Jamora and Fuchs, 2002, Jenkins et al., 2002, Kowalczyk and Moses, 2002, Lee and Kolodziej, 2002, Tazuke et al., 2002, Bilder, 2001, Lu et al., 2001, Roth, 2001, Hemavathy et al., 2000, Hunter and Wieschaus, 2000, Knust, 2000, Montell et al., 2000, Wang et al., 2000, Wilk et al., 2000, Wilson and Leptin, 2000, Bienz, 1999, Leptin, 1999, Maroteaux et al., 1999, Montell, 1999, Novak and Dedhar, 1999, The et al., 1999, Lubarsky et al., 1998, Peifer, 1998, Pai et al., 1996, Dubreuil et al., 1995, Eaton et al., 1995)
    compaction defects 5
    dE-Cadherin
    dE-cadherin
    de-cadherin
    shotgun
    (Liu et al., 2020, Xu et al., 2019, Bernard et al., 2018, Lee et al., 2016, Peters and Berg, 2016, Wieschaus and Nüsslein-Volhard, 2016, Hunter et al., 2015, Sherrard and Fehon, 2015, Carvalho et al., 2014, Chandran et al., 2014, Gao et al., 2014, Rudrapatna et al., 2014, Taniguchi et al., 2014, Geisbrecht et al., 2013, Giuliani et al., 2013, Huelsmann et al., 2013, Wang et al., 2013, Atallah et al., 2012, Gates, 2012, Jemc et al., 2012, Abreu-Blanco et al., 2011, Cammarato et al., 2011, Degennaro et al., 2011, Eliazer and Buszczak, 2011, Furman and Bukharina, 2011, Huang et al., 2011, Oda and Takeichi, 2011, Tjota et al., 2011, Doronkin et al., 2010, Haruta et al., 2010, Ho et al., 2010, Shao et al., 2010, Zimmerman et al., 2010, Boyle and Berg, 2009, Fichelson et al., 2009, Genevet et al., 2009, Huang et al., 2009, Langton et al., 2009, Umemori et al., 2009, Dansereau and Lasko, 2008, DeFalco et al., 2008, Harris and Tepass, 2008, Jin et al., 2008, Johnson et al., 2008, Kunwar et al., 2008, Larson et al., 2008, Liu et al., 2008, Maeda et al., 2008, Melani et al., 2008, Seppa et al., 2008, Shindo et al., 2008, Steinberg et al., 2008, Voog et al., 2008, Araujo et al., 2007, Blankenship et al., 2007, Corrigall et al., 2007, Gandille et al., 2007, Gorfinkiel and Arias, 2007, Hackney et al., 2007, Hayden et al., 2007, Montrasio et al., 2007, Neuman-Silberberg, 2007, Sasaki et al., 2007, Bayraktar et al., 2006, Jiang and Crews, 2006, Mathews et al., 2006, McCaffrey et al., 2006, Mirkovic and Mlodzik, 2006, Fox et al., 2005, Pacquelet and Rorth, 2005, Harris and Peifer, 2004, Rogers et al., 2003, Iwai et al., 1997, Oda et al., 1997, Sanson and Vincent, 1997)
    Secondary FlyBase IDs
    • FBgn0010661
    • FBgn0012050
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (1,359)