FlyBase Gene Report: Dmel\shg

central brain anlage in statu nascendi

(Tepass et al., 1996)

embryonic/larval hindgut

(Tepass et al., 1996)

embryonic stage 8

ventral neurectoderm

(Tepass et al., 1996)

dorsal ectoderm

(Tepass et al., 1996)

unfertilized egg stage

unfertilized egg

(Tepass et al., 1996)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

(Fisher et al., 2012)

ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal head epidermis primordium

(Fisher et al., 2012)

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

labial sensory complex primordium

Comment: reported as labial complex specific anlage

(Fisher et al., 2012)

maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland body specific anlage

(Fisher et al., 2012)

salivary gland duct anlage

Comment: reported as salivary gland duct specific anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

antennal primordium

(Fisher et al., 2012)

Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

embryonic inner optic lobe primordium

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

embryonic outer optic lobe primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

gnathal primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

salivary gland duct primordium

(Fisher et al., 2012)

stomatogastric nervous system primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

clypeo-labral disc primordium

(Fisher et al., 2012)

embryonic primordium of adult eye

(Fisher et al., 2012)

embryonic precursor of adult foregut

(Fisher et al., 2012)

atrium

(Fisher et al., 2012)

Bolwig organ

(Fisher et al., 2012)

dorsal head epidermis

(Fisher et al., 2012)

embryonic antennal sense organ

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic esophagus

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic foregut sensory structure

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic labial sensory complex

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic maxillary sensory complex

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic proventriculus inner layer

(Fisher et al., 2012)

embryonic proventriculus intermediate layer

(Fisher et al., 2012)

embryonic salivary gland duct

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval circulatory system

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

embryonic/larval salivary gland body

(Fisher et al., 2012)

embryonic/larval salivary gland common duct

(Fisher et al., 2012)

gonad

(Fisher et al., 2012)

labral segment

(Fisher et al., 2012)

labral sensory complex

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

embryonic stage 14

embryonic/larval heart anchoring cell

(Zmojdzian et al., 2008)

cardioblast

(Zmojdzian et al., 2008)

oogenesis stage S9

centripetal follicle cell

(Zartman et al., 2009)

polar follicle cell

(Zartman et al., 2009)

oogenesis stage S10A

(Zartman et al., 2009)

oogenesis stage S10B -- S12

floor cell

(Zartman et al., 2009)

roof cell

(Zartman et al., 2009)

dorsal appendage forming follicle cell

(Zartman et al., 2009)

Additional Descriptive Data

shg is expressed in border follicle cells at oogenesis stage 9 before border cell migration. Expression shifts from an anterior band (centripetally migrating follicle cells) at stage S10A to strong expression in midline cells and weak expression in floor and roof cells at stage S10B. Expression continues in stages S11 and S12 in cells forming the dorsal anterior eggshell structures and in posterior follicle cells.

(Zartman et al., 2009)

shg is detected throughout embryogenesis, in all epithelial tissues except for the mesoderm and posterior endoderm. shg expression decreases in neural precursors undergoing the epithelial-mesenchymal transition.

(Tepass et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval salivary gland

hub cell

(Le Bras and Van Doren, 2006)

distribution deduced from reporter or direct label

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

follicle cell

• plasma membrane

(Dorman et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

ectoderm

• zonula adherens

(Dumstrei et al., 2002)

(Oda et al., 1994)

embryonic/larval hindgut

(Oda et al., 1994)

epidermis

(Oda et al., 1994)

Malpighian tubule

(Oda et al., 1994)

embryonic/larval tracheal system

(Oda et al., 1994)

embryonic stage 17

gonad | anterior | restricted

• plasma membrane

Comment: male embryo

(Jenkins et al., 2003)

gonadal sheath proper primordium

(Le Bras and Van Doren, 2006)

embryonic stage 13 -- 14

gonad | restricted

• plasma membrane

(Jenkins et al., 2003)

embryonic stage 5

(Oda et al., 1994)

embryonic stage 13 -- 16

tracheal fusion cell | vicinity of

Comment: between tracheal fusion cells

(Tanaka et al., 2004)

pupal stage

retina

• adherens junction

(Hayashi and Carthew, 2004)

retina

• adherens junction

(Hayashi and Carthew, 2004)

embryonic stage 13

cell

• plasma membrane

(Narasimha and Brown, 2004)

Malpighian tubule Type I cell

(Campbell et al., 2010)

Malpighian tubule Type II cell

(Campbell et al., 2010)

embryonic stage 16

epithelial cell of embryonic/larval salivary gland

• adherens junction

(Paul et al., 2003)

embryonic/larval tracheocyte

• adherens junction

(Paul et al., 2003)

epidermal cell

• adherens junction

(Paul et al., 2003)

oogenesis

follicle cell

(Pacquelet and Rorth, 2005)

third instar larval stage

(Pacquelet and Rorth, 2005)

inner proliferation zone | restricted

(Apitz and Salecker, 2015)

optic lobe neuroepithelial cell

(Southall et al., 2013)

medullary zone of lymph gland primary lobe

(Jung et al., 2005)

secondary lobe of embryonic/larval lymph gland

(Jung et al., 2005)

wing vein L3

(O'Keefe et al., 2007)

wing vein L4

(O'Keefe et al., 2007)

wing margin

(O'Keefe et al., 2007)

larval stage

medullary zone of lymph gland primary lobe

(Sinenko et al., 2009)

prohemocyte

(Sinenko et al., 2009)

embryonic stage 14

embryonic/larval heart anchoring cell

(Zmojdzian et al., 2008)

cardioblast

(Zmojdzian et al., 2008)

ring gland

(Zmojdzian et al., 2008)

spermatogenesis

hub cell

(Voog et al., 2008)

cyst cell of testis

(Voog et al., 2008)

adult stage | male

sex comb

(Atallah et al., 2009)

prothoracic tarsal bristle

(Atallah et al., 2009)

ocellus rhabdomere | variable

(Mishra et al., 2012)

early third instar larval stage

tract

(Fung et al., 2009)

late third instar larval stage

tract

(Fung et al., 2009)

oogenesis stage S8 & adult stage | female

follicle cell | apical

(Talamillo et al., 2013)

adult stage | female oogenesis stage S8 -- S10

day 7 of adulthood -- day 49 of adulthood

(Gunawan et al., 2013)

pupal stage P6

wing margin

(O'Keefe et al., 2007)

wing vein

Comment: sub-apically located

(O'Keefe et al., 2007)

wing cell

Comment: basally located

(O'Keefe et al., 2007)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult heart

(Cammarato et al., 2011)

integral component of plasma membrane

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

shg protein is restricted to the apical portion of cell-cell contacts in ectodermal epithelia, in a region distinct from that of Fas3 protein (a marker for septate junction) localization.

(Apitz and Salecker, 2015, Uemura et al., 1996)

In ocelli, shg is concentrated at the distal and proximal ends of rhabdomeres.

(Mishra et al., 2012)

In stage 13 embryos shg is expressed in Malpighian tubule Type II (stellate) cells, particularly those that contact the tubule lumen but is lower than in the neighboring Malpighian tubule Type I (principal) cells. All Malpighian tubule Type II cells contact the luminal surface of the tubules in mid stage 14 and express high levels of shg as well as crb, baz, and dlg1.

(Campbell et al., 2010)

At the early third instar, secondary axon tracts form bundles of 20 to 50 fibers traversing the cortex and reaching the cortex-neuropile boundary. All early fibers express shg. In later third instar larvae, these axon tracts have grown and matured and no longer express shg. Late born, immature fibers grow at the center of these tracts and these younger fibers express shg.

(Fung et al., 2009)

shg protein concentrates at hub cell junctions. It is expressed in cyst cells and strongly enriched in the hub.

(Voog et al., 2008)

shg protein is concentrated at the apical portion of cell-cell contacts in differentiated epithelial layers.

(Li et al., 2007, Oda et al., 1994)

shg is expressed in the anterior cluster of somatic gonadal precursor cells in the stage 17 embryonic gonad. It is also expressed in the adult hub.

(Le Bras and Van Doren, 2006)

PPO1 protein is localized to maturing crystal cells in the lymph gland cortical zone.

(Jung et al., 2005)

shg is localized to the adherens junctions of the cell-cell interfaces of all cells of the retina.

(Hayashi and Carthew, 2004)

In stage 13 embryos,shg protein expression is detected on the cell membrane of both somatic germline precursor cells as well as the germline cells in both males and females. This localization is concurrent with the processes of ensheathment and coalescence of the developing gonad. In stage 17 male embryos, shg protein is concentrated in the anterior of the gonad in the region corresponding to the testes hub.

(Jenkins et al., 2003)

shg protein was first observed along cell-cell boundaries at the cellular blastoderm stage. At germ band elongation, it is present homogeneously in the epidermal ectoderm of the embryo. shg protein expression persists in the ectodermal epithelia including the epidermis, salivary glands, Malpighian tubules, hindgut and tracheal system throughout embryogenesis.

(Oda et al., 1994)

Marker for

adherens junction

(Hayashi and Carthew, 2004)

Subcellular Localization

CV Term

Evidence

References

adherens junction

inferred from direct assay

(Yashiro et al., 2014, Haruta et al., 2010)

apical junction complex

inferred from direct assay

(Pilot et al., 2006)

catenin complex

inferred from direct assay

(Menzel et al., 2008)

cell cortex

inferred from direct assay

(Bardet et al., 2013)

filopodium

inferred from direct assay

(Liu et al., 2008)

inferred from direct assay

(Mavrakis et al., 2009, Oda et al., 1994)

plasma membrane

inferred from direct assay

(assigned by UniProt )

(Melani et al., 2008)

recycling endosome

inferred from direct assay

(de Madrid et al., 2015)

spot adherens junction

inferred from direct assay

(Harris and Peifer, 2004)

Expression Deduced from Reporters

Reporter: P{PZ}shg¹⁰⁴⁶⁹

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

third segment of antenna

(Vosshall, 1998.8.10)

lamina

(Vosshall, 1998.8.10)

embryonic stage

embryonic/larval trachea

(Meister and Braun, 1995.10)

imaginal disc

(Meister and Braun, 1995.10)

embryonic/larval brain

(Meister and Braun, 1995.10)

Reporter: P{shg-lacZ.1.3}

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S8 -- S10 & adult stage | female

wandering third instar larval stage

(Gunawan et al., 2013)

Reporter: P{ST.lexA::HG}shg^SE205

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\shg in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\shg

View exonic expression by tissue for Dmel\shg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003391

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0003391

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3722-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3722

Flygut - An atlas of the Drosophila adult midgut

FBgn0003391

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\shg

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 64 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 75 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of shg

Transgenic constructs containing regulatory region of shg

Deletions and Duplications ( 7 )

Disrupted in

Df(2R)BSC462

(Christensen et al., 2008.4.15)

Df(2R)BSC814

(Kahsai et al., 2016, Christensen et al., 2009.5.6)

Df(2R)E2

(Kraut, 2000.8.14, Cox et al., 1996, Uemura et al., 1996)

Df(2R)Pu-D17

(Spradling et al., 1999, Tepass et al., 1996, Uemura et al., 1996, BDGP Project Members, 1994-1999)

Not disrupted in

Df(2R)017

(Cox et al., 2000)

Df(2R)D4

(Kraut, 2000.8.14, Kraut and Campos-Ortega, 1996)

Df(2R)XE3030

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^NP1548

shg^UAS.cUa

lethal, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

lethal (with Df(2R)BSC814)

shg²

lethal (with shg²)

shg^E17D

lethal (with shg^E17D)

shg²

lethal | recessive

lethal - all die before end of embryonic stage

lethal - all die before end of embryonic stage, with Scer\GAL4^VP16.arm

lethal - all die before end of embryonic stage | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

shg^GD14421

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

shg^GD2659

viable, with Scer\GAL4^pnr-MD237

shg^GD2659

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

cell adhesion defective | late third instar larval stage | somatic clone

shg¹

cell adhesion defective | maternal effect

cell adhesion defective | oogenesis, with Scer\GAL4^upd1.PU

shg^HMS00693

cell adhesion defective | third instar larval stage, with Scer\GAL4^dpp.PU

shg^UAS.cSa

cell migration defective

shg^k03401

cell migration defective, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

cell migration defective, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, shg^GD14421, shg^HMS00693

shg^KK103334

cell migration defective, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, shg^GD14421, shg^KK103334

shg^HMS00693

cell migration defective, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, shg^HMS00693, shg^KK103334

shg^GD14421

cell migration defective, with Scer\GAL4^slbo.2.6

shg^GD14421

cell migration defective, with Scer\GAL4^slbo.2.6, shg^GD14421, shg^HMS00693

shg^KK103334

cell migration defective, with Scer\GAL4^slbo.2.6, shg^GD14421, shg^KK103334

shg^HMS00693

cell migration defective, with Scer\GAL4^slbo.2.6, shg^HMS00693, shg^KK103334

shg^GD14421

cell migration defective | germline clone

shg^R69

cell migration defective | maternal effect

cell migration defective | oogenesis | oogenesis, with Scer\GAL4^slbo.2.6

shg^HMS00693

cell migration defective | somatic clone

shg^R69

cell migration defective | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

cell migration defective | third instar larval stage, with Scer\GAL4^dpp.PU

cell polarity defective

shg^R6

cell polarity defective, with Scer\GAL4^hs.2sev

shg^{dCR3h.UAS.sgGFP}

cell polarity defective, with Scer\GAL4^hs.2sev, shg¹

shg^{dCR3h.UAS.sgGFP}

cell polarity defective, with Scer\GAL4^hs.2sev, shg²

shg^{dCR3h.UAS.sgGFP}

cell polarity defective, with Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

cell polarity defective, with Scer\GAL4^hs.2sev, shg^ex.UAS

shg^{dCR3h.UAS.sgGFP}

cell polarity defective, with Scer\GAL4^hs.2sev, shg^k03401

shg^{dCR3h.UAS.sgGFP}

cell polarity defective, with Scer\GAL4^hs.2sev, shg^Δβ.UAS

shg^{dCR3h.UAS.sgGFP}

cell polarity defective | cell autonomous | pupal stage | somatic clone

cell polarity defective | cell non-autonomous | somatic clone

shg^k03401

cell shape defective | larval stage, with Scer\GAL4^nrv2.PS

shg^ex.UAS

cell shape defective | recessive

shg^g119

cell shape defective | somatic clone

cell shape defective | somatic clone | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

cell shape defective | third instar larval stage, with Scer\GAL4^e22c

shg^GD14421

decreased cell number, with Scer\GAL4^NP7397

shg^NIG.3722R

decreased cell number | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

decreased cell number | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

decreased cell number | dominant | progressive

decreased cell number | larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

decreased cell number | third instar larval stage, with Scer\GAL4^C587

shg^{dsRNA.UAS.cVa}

decreased occurrence of cell division | larval stage, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

decreased occurrence of cell division | larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

flightless, with Scer\GAL4^Mef2.PR

shg^GD14421

immune response defective | adult stage | dominant

shg^GE13814

increased cell death

shg²

increased cell death | late third instar larval stage | somatic clone

shg¹

increased cell number | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

increased cell size | third instar larval stage, with Scer\GAL4^e22c

shg^GD14421

mitotic cell cycle defective | second instar larval stage, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

mitotic cell cycle defective | third instar larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

neuroanatomy defective | late third instar larval stage | somatic clone

shg¹

size defective | larval stage, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

size defective | larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

size defective | larval stage | somatic clone

shg^R69

some die during embryonic stage

some die during embryonic stage, with Scer\GAL4^VP16.arm

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

shg^GD14421

visible, with Scer\GAL4^en.PU

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

visible, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

visible, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

visible, with Scer\GAL4^vg.PM

shg^UAS.cOa

visible | recessive

shg^R6

wild-type

shg^{Ubi-p63E.sgGFP}

wound healing defective, with Scer\GAL4^{VP16.mat.αTub67C}

shg^{Ubi-p63E.sgGFP}

wound healing defective | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^UAS.sgGFP

wound healing defective | maternal effect | recessive

shg^k03401

Phenotype manifest in

Allele

actin filament | embryonic stage

shg^g317

adherens junction | embryonic stage

shg²

adherens junction | embryonic stage, with shg^{DEΔ734-1316.Ubi.EGFP}

shg^R69

adherens junction | embryonic stage, with shg^R69

shg^{DEΔ734-1316.Ubi.EGFP}

adherens junction | late third instar larval stage | somatic clone

shg¹

shg^g317

anterior protocerebral neuromere, with Scer\GAL4^hs.PH

shg^ex.UAS

apical part of cell | cell autonomous | pupal stage | somatic clone

Bolwig organ

shg²

Bolwig organ, with Scer\GAL4^da.G32

shg^UAS.cSa

border follicle cell | germline clone

border follicle cell, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

border follicle cell, with Scer\GAL4^slbo.2.6

border follicle cell, with Scer\GAL4^upd1.PU

shg^HMS00693

border follicle cell & filopodium | somatic clone

shg¹

border follicle cell & filopodium | somatic clone | cell non-autonomous

shg¹

shg^R69

border follicle cell | somatic clone

cardioblast

cardioblast & adherens junction

shg^k03401

cell body glial cell, with Scer\GAL4^hs.PH

shg^ex.UAS

centripetal follicle cell

shg²

centripetal follicle cell | germline clone

shg^R69

centripetal follicle cell | somatic clone

shg^R69

cone cell, with Scer\GAL4^GMR.PF

shg^UAS.sgGFP

cone cell | somatic clone

shg^R69

cone cell | somatic clone, with Scer\GAL4^Act5C.PI

shg^UAS.sgGFP

cyst progenitor cell

shg¹

cyst progenitor cell | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

cyst progenitor cell | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

denticle & embryonic epidermis | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

denticle | ectopic | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

denticle | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

egg

shg^{Ubi-p63E.sgGFP}

egg | germline clone

egg chamber

shg^k03401

egg chamber | somatic clone

shg^R69

embryo | gastrula stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle, with Scer\GAL4^VP16.arm

shg^UAS.cSa

embryonic/first instar larval cuticle & embryonic head

shg^g119

embryonic/first instar larval cuticle | dorsal, with Scer\GAL4^arm.PS

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

embryonic/first instar larval cuticle | lateral

embryonic/first instar larval cuticle | ventral

embryonic/larval brain, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

embryonic/larval brain, with Scer\GAL4^hs.PH

shg^ex.UAS

embryonic/larval cell body glial cell, with Scer\GAL4^nrv2.PS

shg^ex.UAS

embryonic/larval dorsal branch | embryonic stage (with shg²)

shg^E17B

embryonic/larval dorsal branch | embryonic stage (with shg^E17B)

shg²

embryonic/larval dorsal trunk

embryonic/larval dorsal trunk (with shg²)

shg^E17B

embryonic/larval dorsal trunk (with shg^E17B)

shg²

embryonic/larval dorsal vessel

shg^J2B2

embryonic/larval epidermis | third instar larval stage, with Scer\GAL4^e22c

shg^GD14421

embryonic/larval hindgut

embryonic/larval hindgut (with shg^R69)

shg^R758

embryonic/larval hindgut (with shg^R758)

shg^R69

embryonic/larval salivary gland, with Scer\GAL4^AB1

shg^UAS.sgGFP

embryonic/larval trachea

shg^R69

embryonic/larval tracheal system

embryonic/larval tracheal system, with Scer\GAL4^btl.PS

shg^AAA-JXT.UAS

embryonic epidermis

embryonic epidermis, with Scer\GAL4^da.G32

shg^ex.UAS

embryonic epidermis, with Scer\GAL4^{VP16.mat.αTub67C}

embryonic epidermis & embryonic head

embryonic epidermis | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

embryonic head

embryonic head, with shg^{DEΔ734-1316.Ubi.EGFP}

shg^R69

embryonic head, with shg^{DEΔ833-1316.Ubi.EGFP}

shg^R69

embryonic head, with shg^R69

embryonic head & embryonic/first instar larval cuticle

embryonic head epidermis

embryonic optic lobe primordium

shg²

embryonic optic lobe primordium, with Scer\GAL4^da.G32

shg^UAS.cSa

embryonic trachea & cortical actin cytoskeleton

shg²

embryonic ventral epidermis

embryonic ventral epidermis, with shg^{DEΔ833-1316.Ubi.EGFP}

shg^R69

embryonic ventral epidermis, with shg^R69

shg^{DEΔ833-1316.Ubi.EGFP}

endoderm

epithelial cell

epithelial cell, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

epithelial cell | somatic clone

shg^R69

epithelial cell | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

epithelial cell | third instar larval stage, with Scer\GAL4^dpp.PU

eye, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

fascicle, with Scer\GAL4^elav-C155

shg^ex.UAS

fat body/gonad primordium

shg^g317

fat body/gonad primordium, with Scer\GAL4^VP16.nos.UTR

shg^UAS.cSa

fat body/gonad primordium | male

shg^g317

female germline cyst | progressive

female germline cyst | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

female germline stem cell | germline clone

shg^R69

female germline stem cell | germline clone, with Scer\GAL4^VP16.nos.UTR

shg^{UASp.Tag:FLAG}

female germline stem cell | germline clone | progressive

shg^KK103334

female germline stem cell | progressive

female germline stem cell | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

female germline stem cell | somatic clone

shg^R69

flight muscle, with Scer\GAL4^Mef2.PR

shg^GD14421

follicle cell, with shg¹

shg^{Δβ.αTub84B}

follicle cell, with shg^{Δβ.αTub84B}

shg¹

follicle cell | somatic clone

shg¹

follicle stem cell | somatic clone

germarium | progressive

germarium | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

germarium cap cell | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

germinal proliferation center hub, with Scer\GAL4^C587

shg^{dsRNA.UAS.cVa}

germline cell

shg²

germline cell | embryonic stage | maternal effect

shg^g317

germline cell | maternal effect

gonad | embryonic stage

shg^R69

gonad | embryonic stage (with shg²)

shg^R64a

gonad | embryonic stage (with shg^19.7)

shg^81.05

gonad | embryonic stage (with shg^81.05)

shg^19.7

gonad | embryonic stage (with shg^R64a)

shg²

gonadal sheath proper primordium

gonadal sheath proper primordium, with Scer\GAL4^VP16.nos.UTR

shg^UAS.cSa

gonadal sheath proper primordium | male

shg^g317

head

head, with Scer\GAL4^VP16.arm

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

hemocyte | adult stage

shg^GE13814

histoblast | somatic clone

shg^{Ubi-p63E.sgGFP}

histoblast nest | somatic clone

shg^{Ubi-p63E.sgGFP}

hub cell | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

hub cell | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

imaginal disc | somatic clone

shg^R69

indirect flight muscle, with Scer\GAL4^Mef2.PR

shg^GD14421

interommatidial bristle | ectopic, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

lamina cortex & satellite glial cell, with Scer\GAL4^nrv2.PS

shg^ex.UAS

larval outer optic anlage | late third instar larval stage | somatic clone

shg¹

male accessory gland secondary cell, with Scer\GAL4^NP7397

shg^NIG.3722R

male genitalia, with Scer\GAL4^Abd-B-LDN

male genitalia, with Scer\GAL4^NP1548

shg^KK103334

male germline stem cell

shg¹

male germline stem cell, with Scer\GAL4^C587

shg^{dsRNA.UAS.cVa}

male germline stem cell | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

male germline stem cell | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

male germline stem cell | germline clone

shg^R69

male germline stem cell | somatic clone, with Scer\GAL4^{VP16.nos.-FRT}

shg^UAS.sgGFP

Malpighian tubule

mesothoracic tergum | cell autonomous | pupal stage | somatic clone

microchaeta & mesothoracic tergum, with Scer\GAL4^pnr-MD237

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

microchaeta | supernumerary & mesothoracic tergum, with Scer\GAL4^pnr-MD237

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

microtubule & adherens junction, with Scer\GAL4^btl.PS

shg^AAA-JXT.UAS

morphogenetic furrow, with Scer\GAL4^dpp.blk1

shg^DN.UAS

myofibril, with Scer\GAL4^Mef2.PR

shg^GD14421

neuroblast, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

neuroblast, with Scer\GAL4^hs.PH

shg^ex.UAS

neuroblast, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

neuroblast | ectopic, with Scer\GAL4^elav-C155

shg^ex.UAS

neurogenic region

shg^g317

neurogenic region, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

neuropil, with Scer\GAL4^hs.PH

shg^ex.UAS

neuropil associated CNS glial cell, with Scer\GAL4^hs.PH

shg^ex.UAS

nucleus | blastoderm stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

nurse cell | germline clone

shg¹

nurse cell ring canal | germline clone

shg¹

ommatidial precursor cluster | cell non-autonomous | somatic clone

shg^k03401

ommatidium

shg^R6

ommatidium, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

ommatidium, with Scer\GAL4^hs.2sev

ommatidium, with Scer\GAL4^hs.2sev, shg¹

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg²

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^ex.UAS

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^k03401

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^Δβ.UAS

shg^{dCR3h.UAS.sgGFP}

oocyte

oocyte | cell non-autonomous | somatic clone, with Scer\GAL4^Act5C.PP

shg^UAS.cSa

oocyte | germline clone

oocyte | somatic clone

optic lobe neuroepithelial cell | late third instar larval stage | somatic clone

shg¹

organism | embryonic stage

shg^k03401

ovary | germline clone

plasma membrane | blastoderm stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

posterior crossvein, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

posterior spiracle primordium

shg²

presumptive embryonic/larval nervous system

shg²

presumptive embryonic/larval peripheral nervous system

shg^g317

presumptive embryonic/larval tracheal system

shg^g119

primary pigment cell | somatic clone

shg^R69

sarcomere, with Scer\GAL4^Mef2.PR

shg^GD14421

scutum, with Scer\GAL4^arm.PS

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

sensory mother cell, with Scer\GAL4^neur-P72

shg^{dCPc3.UAS.sgGFP}

sensory mother cell | somatic clone

spindle, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

stomatogastric nervous system | embryonic stage

shg^g317

tracheal branch primordium

tracheal system

shg²

tracheolar cell

shg²

ventral furrow, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

ventral furrow, with shg^{DEΔ734-1316.Ubi.EGFP}

shg^R69

ventral furrow, with shg^R69

shg^{DEΔ734-1316.Ubi.EGFP}

visual primordium

shg^g317

wing

wing, with Scer\GAL4^arm.PS

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing, with Scer\GAL4^en-e16E

wing | posterior, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing blade, with Scer\GAL4^en.PU

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing blade | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

shg^KK103334

wing blade posterior compartment, with Scer\GAL4^en-e16E

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

shg^UAS.cSa

wing disc | somatic clone | third instar larval stage

shg¹

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing disc | third instar larval stage, with Scer\GAL4^dpp.PU

wing hair | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

shg^KK103334

wing margin, with Scer\GAL4^en-e16E

wing margin, with Scer\GAL4^vg.PM

wing margin | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

shg^KK103334

wing margin bristle, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

zonula adherens | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CDH20

1 of 15

Yes

Hsap\CDHR2

1 of 15

Yes

Hsap\DSG1

1 of 15

Yes

Hsap\FAT1

1 of 15

Yes

Hsap\FAT2

1 of 15

Yes

Hsap\FAT3

1 of 15

Yes

Hsap\FAT4

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cdh20

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Dsg1b

1 of 15

Yes

Mmus\Dsg1c

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (18)

Rnor\Cdh1

1 of 13

Yes

Rnor\Cdh2

1 of 13

Yes

Rnor\Cdh6

1 of 13

Yes

Rnor\Cdh7

1 of 13

Yes

Rnor\Cdh8

1 of 13

Yes

Rnor\Cdh9

1 of 13

Yes

Rnor\Cdh10

1 of 13

Yes

Rnor\Cdh11

1 of 13

Yes

Rnor\Cdh12

1 of 13

Yes

Rnor\Cdh18

1 of 13

Yes

Rnor\Cdh19

1 of 13

Yes

Rnor\Cdh20

1 of 13

Yes

Rnor\Cdh22

1 of 13

Yes

Rnor\Cdh24

1 of 13

Yes

Rnor\Fat1

1 of 13

Yes

Rnor\Fat2

1 of 13

Yes

Rnor\Fat3

1 of 13

Yes

Rnor\Fat4

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\LOC100493382

1 of 12

Yes

Xtro\LOC100494953

1 of 12

Yes

Danio rerio (Zebrafish) (7)

Drer\si:ch211-186j3.6

3 of 15

Yes

Drer\si:dkey-22o22.2

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\hmr-1

3 of 15

Yes

Cele\cdh-1

1 of 15

Cele\cdh-9

1 of 15

Cele\cdh-12

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900IG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24111

Drosophila persimilis

Dper\GL10186

Drosophila willistoni

Dwil\GK22947

Drosophila virilis

Dvir\GJ20342

Drosophila mojavensis

Dmoj\GI20567

Drosophila grimshawi

Dgri\GH21371

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017823

Glossina morsitans

Tsetse fly

Gmor\GMOY010182

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11402

Mayetiola destructor

Hessian fly

Mdes\Mdes009081

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012421

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013873

Anopheles darlingi

American malaria mosquito

Adar\ADAC009178

Anopheles gambiae

Malaria mosquito

Agam\AGAP007203

Anopheles gambiae

Malaria mosquito

Agam\AGAP007216

Anopheles gambiae

Malaria mosquito

Agam\AGAP007207

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011270

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00C0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010266

Danaus plexippus

Monarch butterfly

Dple\DPOGS216145-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008474

Apis florea

Little honeybee

Aflo\3031489812

Apis mellifera

Western honey bee

Amel\GB50219

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14854

Bombus terrestris

Buff-tailed bumblebee

Bter\15205566

Linepithema humile

Argentine ant

Lhum\LH17734

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002098

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013604

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06698

Tribolium castaneum

Red flour beetle

Tcas\TC013570

Pediculus humanus

Human body louse

Phum\PHUM458490

Rhodnius prolixus

Kissing bug

Rpro\RPRC010135

Cimex lectularius

Bed bug

Clec\CLEC004828

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002536

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02288

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00BF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001807

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_304677

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

kug

1 of 10

stan

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

shg^UAS.cSa

model of cancer

CEA

(Shen et al., 2014)

shg^NIG.3722R

model of prostate cancer

CEA

(Ito et al., 2014)

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

model of cancer

CEA

(Shen et al., 2014)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

shg^UAS.cOa

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib¹

(Pagliarini and Xu, 2003)

shg^UAS.cSa

DOES NOT ameliorate cancer

modeled by bi^UAS.cPa

(Shen et al., 2014)

model of cancer

is NOT ameliorated by bi^UAS.cBa

(Shen et al., 2014)

is NOT ameliorated by bi^UAS.cPa

(Shen et al., 2014)

shg^NIG.3722R

exacerbates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

shg^UASp.cUa

ameliorates cancer

modeled by Myc^αTub84B.PBb

(Levayer et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bead aggregation assay, fluorescence microscopy, inferred by author

(Nishiguchi et al., 2016, Lovegrove et al., 2006)

shg - Egfr

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Dumstrei et al., 2002)

shg - Hakai

(Kaido et al., 2009)

shg - Inx2

anti bait coimmunoprecipitation, western blot, two hybrid

(Bauer et al., 2004)

shg - Inx3

anti tag coimmunoprecipitation, western blot

(Giuliani et al., 2013)

shg - Mmp1

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

shg - Mmp2

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

shg - Myo10A

anti bait coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography

(Liu et al., 2008)

shg - Myo31DF

anti tag coimmunoprecipitation, western blot

(Petzoldt et al., 2012)

shg - N

(Sasaki et al., 2007)

shg - baz

pull down, molecular weight estimation by staining

(Bulgakova et al., 2013, Harris and Peifer, 2005)

shg - cno

(Sawyer et al., 2009)

shg - lqfR

anti tag coimmunoprecipitation, western blot

(Lee and Fischer, 2012)

shg - p120ctn

two hybrid, anti tag coimmunoprecipitation, western blot, pull down, autoradiography

(Liu et al., 2008, Myster et al., 2003)

shg - wrapper

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Slováková and Carmena, 2011)

shg - α-Cat

(Desai et al., 2013, Iwai et al., 1997, Oda et al., 1994)

RNA-protein

Physical Interaction

Assay

References

shg - Hrb98DE

anti bait coimmunoprecipitation, quantitative reverse transcription pcr, nucleic acid uv cross-linking assay, tag visualisation, electrophoretic mobility shift assay, reverse transcription pcr

(Ji and Tulin, 2016, Ji and Tulin, 2012)

shg - aub

iclip, partial RNA sequence identification

(Ma et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

AGO1

(Kataoka et al., 2001)

enhanceable

AGO1

(Kataoka et al., 2001)

enhanceable

(Mirkovic and Mlodzik, 2006, Bauer et al., 2000, Greaves et al., 1999, Waltzer and Bienz, 1998)

suppressible

(Kataoka et al., 2001)

enhanceable

brm

(Barker et al., 2001)

enhanceable

btl::Egfr

(Dumstrei et al., 2002)

enhanceable

CadN

(Mirkovic and Mlodzik, 2006)

suppressible

Cdk1

(Greaves et al., 1999)

suppressible

crb

(Greaves et al., 1999)

suppressible

(Tepass et al., 1996)

enhanceable

dgo

(Mirkovic and Mlodzik, 2006)

Vang|shg

enhanceable

dgo

(Mirkovic and Mlodzik, 2006)

suppressible

dlg1

(Greaves et al., 1999)

suppressible

(Greaves et al., 1999)

enhanceable

dsh

(Greaves et al., 1999)

shg|Ras85D

enhanceable

egr

(Igaki et al., 2006)

suppressible

Fas3

(Greaves et al., 1999)

suppressible

(Greaves et al., 1999)

Ras85D|shg

suppressible

hep

(Igaki et al., 2006)

enhanceable

Jafrac1

(Degennaro et al., 2011)

suppressible

l(2)dC9

(Greaves et al., 1999)

suppressible

l(3)09291

(Greaves et al., 1999)

suppressible

lilli

(Greaves et al., 1999)

enhanceable

Mad

(Cordero et al., 2007)

enhanceable

mor

(Barker et al., 2001)

suppressible

Myo61F

(Petzoldt et al., 2012)

suppressible

(Tepass et al., 1996)

suppressible

nej

(Waltzer and Bienz, 1998)

suppressible

nkd

(Greaves et al., 1999)

enhanceable

p120ctn

(Myster et al., 2003)

suppressible

Pak

(Lee and Thomas, 2011)

enhanceable

pan

(Barker et al., 2001)

enhanceable

pont

(Bauer et al., 2000)

suppressible

rept

(Bauer et al., 2000)

enhanceable

Rho1

(Mirkovic and Mlodzik, 2006, Fox et al., 2005)

suppressible

(Fox et al., 2005)

suppressible

(Dumstrei et al., 2002)

suppressible

sdt

(Greaves et al., 1999)

suppressible

sgg

(Greaves et al., 1999)

suppressible

shg::Mmus\Cdh1

(Pacquelet and Rorth, 2005)

suppressible

shg::Rnor\Cd2::α-Cat

(Pacquelet and Rorth, 2005)

suppressible

stg

(Greaves et al., 1999)

enhanceable

tkv

(Cordero et al., 2007)

suppressible

Traf4

(Mathew et al., 2011)

suppressible

tws

(Greaves et al., 1999)

enhanceable

tws

(Bajpai et al., 2004)

suppressible

tyn

(Greaves et al., 1999)

dgo|shg

enhanceable

Vang

(Mirkovic and Mlodzik, 2006)

enhanceable

Vang

(Mirkovic and Mlodzik, 2006)

enhanceable

(Greaves et al., 1999)

suppressible

α-Cat::shg

(Pacquelet and Rorth, 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aop

suppressible

(Schober et al., 2005)

Apc|Apc2

enhanceable

(Wang et al., 2013)

enhanceable

(Greaves et al., 1999)

suppressible

(Loureiro and Peifer, 1998)

baz

enhanceable

(Shao et al., 2010)

suppressible

(Jin et al., 2008)

enhanceable

(Johnson et al., 2008)

cindr

suppressible

(Johnson et al., 2008)

crb

suppressible

(Flores-Benitez and Knust, 2015)

Csk

enhanceable

(Rudrapatna et al., 2014, Vidal et al., 2006)

Csk

suppressible

(Vidal et al., 2006)

CycE

suppressible

(Wang and Kalderon, 2009, Brumby et al., 2004)

suppressible

(Montrasio et al., 2007)

suppressible

(Morante et al., 2011)

foi

suppressible

(Mathews et al., 2006)

Hrb98DE

suppressible

(Ji and Tulin, 2012)

Hrb98DE|Parg

suppressible

(Ji and Tulin, 2012)

Inx2

suppressible

(Mukai et al., 2011)

jar

suppressible

(Geisbrecht and Montell, 2002)

jub

enhanceable

(Razzell et al., 2018)

suppressible

(Lim et al., 2015)

enhanceable

(Lim et al., 2015)

suppressible

(Tarayrah et al., 2015)

Lis-1

suppressible

(Chen et al., 2010)

miple1

suppressible

(Muñoz-Soriano et al., 2013)

mrva

suppressible

(Valoskova et al., 2019)

Myc

suppressible

(Levayer et al., 2015)

suppressible

(Tseng et al., 2014)

nmo

enhanceable

(Mirkovic et al., 2011)

p120ctn

enhanceable

(Larson et al., 2008, Myster et al., 2003)

Pak

suppressible

(Lee and Thomas, 2011)

Parg

suppressible

(Ji and Tulin, 2012)

enhanceable

(Sen et al., 2012)

suppressible

(Singh et al., 2006, Wang et al., 2006)

pyd

enhanceable

(Seppa et al., 2008)

Rac1

suppressible

(Pirraglia et al., 2006)

RanBPM

enhanceable

(Dansereau and Lasko, 2008)

Ras85D|scrib

suppressible

(Pagliarini and Xu, 2003)

RASSF8

enhanceable

(Langton et al., 2009)

raw

suppressible

(Jemc et al., 2012)

raw

enhanceable

(Jemc et al., 2012)

RhoL

suppressible

(Siekhaus et al., 2010)

enhanceable

(Brown and Freeman, 2003, Gaengel and Mlodzik, 2003)

sca

enhanceable

(Renaud and Simpson, 2001)

scra

suppressible

(Goldbach et al., 2010)

suppressible

(Lee et al., 2016)

enhanceable

(Das et al., 2013)

suppressible

(Das et al., 2013)

enhanceable

(Shindo et al., 2008, Takahashi et al., 2005)

Src42A

suppressible

(Shindo et al., 2008)

Src64B

suppressible

(Fernández et al., 2014)

step

enhanceable

(West et al., 2017)

suppressible

(Gunawan et al., 2013)

tkv

enhanceable

(Cordero et al., 2007)

Vav

enhanceable

(Martín-Bermudo et al., 2015)

α-Cat

enhanceable