FlyBase Gene Report: Dmel\shg

central brain anlage in statu nascendi

(Tepass et al., 1996)

embryonic/larval hindgut

(Tepass et al., 1996)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

(Fisher et al., 2012)

ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut anlage

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 8

ventral neurectoderm

(Tepass et al., 1996)

dorsal ectoderm

(Tepass et al., 1996)

embryonic stage 9 -- 10

dorsal head epidermis primordium

(Fisher et al., 2012)

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

labial sensory complex primordium

Comment: reported as labial complex specific anlage

(Fisher et al., 2012)

maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland body specific anlage

(Fisher et al., 2012)

salivary gland duct anlage

Comment: reported as salivary gland duct specific anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

antennal primordium

(Fisher et al., 2012)

Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

embryonic inner optic lobe primordium

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

embryonic outer optic lobe primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

gnathal primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

salivary gland duct primordium

(Fisher et al., 2012)

stomatogastric nervous system primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 12 -- 17

embryonic/larval tracheal system

(Tepass et al., 1996)

midgut primordium

(Tepass et al., 1996)

embryonic stage 13 -- 16

clypeo-labral disc primordium

(Fisher et al., 2012)

embryonic primordium of adult eye

(Fisher et al., 2012)

embryonic precursor of adult foregut

(Fisher et al., 2012)

larval foregut atrium

(Fisher et al., 2012)

Bolwig organ

(Fisher et al., 2012)

dorsal head epidermis

(Fisher et al., 2012)

embryonic antennal sense organ

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic esophagus

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic foregut sensory structure

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic labial sensory complex

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic maxillary sensory complex

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic proventriculus inner layer

(Fisher et al., 2012)

embryonic proventriculus intermediate layer

(Fisher et al., 2012)

embryonic salivary gland duct

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval circulatory system

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

embryonic/larval salivary gland body

(Fisher et al., 2012)

embryonic/larval salivary gland common duct

(Fisher et al., 2012)

gonad

(Fisher et al., 2012)

labral segment

(Fisher et al., 2012)

labral sensory complex

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

embryonic stage 14

embryonic/larval heart anchoring cell

(Zmojdzian et al., 2008)

cardioblast

(Zmojdzian et al., 2008)

embryonic stage 17

embryonic/larval dorsal vessel

(Tepass et al., 1996)

gonadal sheath

(Tepass et al., 1996)

oogenesis stage S9

centripetal follicle cell

(Zartman et al., 2009)

polar follicle cell

(Zartman et al., 2009)

oogenesis stage S10A

(Zartman et al., 2009)

oogenesis stage S10B -- S12

floor cell

(Zartman et al., 2009)

roof cell

(Zartman et al., 2009)

dorsal appendage forming follicle cell

(Zartman et al., 2009)

unfertilized egg stage

unfertilized egg

(Tepass et al., 1996)

Additional Descriptive Data

shg is expressed in border follicle cells at oogenesis stage 9 before border cell migration. Expression shifts from an anterior band (centripetally migrating follicle cells) at stage S10A to strong expression in midline cells and weak expression in floor and roof cells at stage S10B. Expression continues in stages S11 and S12 in cells forming the dorsal anterior eggshell structures and in posterior follicle cells.

(Zartman et al., 2009)

shg is detected throughout embryogenesis, in all epithelial tissues except for the mesoderm and posterior endoderm. shg expression decreases in neural precursors undergoing the epithelial-mesenchymal transition.

(Tepass et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval salivary gland

hub cell

(Le Bras and Van Doren, 2006)

distribution deduced from reporter or direct label

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

follicle cell

• plasma membrane

(Dorman et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

ectoderm

• zonula adherens

(Dumstrei et al., 2002)

(Oda et al., 1994)

embryonic/larval hindgut

(Oda et al., 1994)

epidermis

(Oda et al., 1994)

Malpighian tubule

(Oda et al., 1994)

embryonic/larval tracheal system

(Oda et al., 1994)

embryonic stage 5

(Oda et al., 1994)

embryonic stage 13

cell

• plasma membrane

(Narasimha and Brown, 2004)

Malpighian tubule Type I cell

(Campbell et al., 2010)

Malpighian tubule Type II cell

(Campbell et al., 2010)

embryonic stage 13 -- 14

gonad | restricted

• plasma membrane

(Jenkins et al., 2003)

embryonic stage 13 -- 16

tracheal fusion cell | vicinity of

Comment: between tracheal fusion cells

(Tanaka et al., 2004)

embryonic stage 14

embryonic/larval heart anchoring cell

(Zmojdzian et al., 2008)

cardioblast

(Zmojdzian et al., 2008)

ring gland

(Zmojdzian et al., 2008)

embryonic stage 16

epithelial cell of embryonic/larval salivary gland

• adherens junction

(Paul et al., 2003)

embryonic/larval tracheocyte

• adherens junction

(Paul et al., 2003)

epidermal cell

• adherens junction

(Paul et al., 2003)

embryonic stage 17

gonad | anterior | restricted

• plasma membrane

Comment: male embryo

(Jenkins et al., 2003)

gonadal sheath proper primordium

(Le Bras and Van Doren, 2006)

larval stage

medullary zone of lymph gland primary lobe

(Sinenko et al., 2009)

prohemocyte

(Sinenko et al., 2009)

third instar larval stage

inner proliferation zone | restricted

(Apitz and Salecker, 2015)

optic lobe neuroepithelial cell

(Southall et al., 2013)

medullary zone of lymph gland primary lobe

(Jung et al., 2005)

secondary lobe of embryonic/larval lymph gland

(Jung et al., 2005)

wing vein L3

(O'Keefe et al., 2007)

wing vein L4

(O'Keefe et al., 2007)

wing margin

(O'Keefe et al., 2007)

early third instar larval stage

tract

(Fung et al., 2009)

late third instar larval stage

tract

(Fung et al., 2009)

pupal stage

retina

• adherens junction

(Hayashi and Carthew, 2004)

retina

• adherens junction

(Hayashi and Carthew, 2004)

pupal stage P6

wing margin

(O'Keefe et al., 2007)

wing vein

Comment: sub-apically located

(O'Keefe et al., 2007)

wing cell

Comment: basally located

(O'Keefe et al., 2007)

adult stage | male

sex comb

(Atallah et al., 2009)

prothoracic tarsal bristle

(Atallah et al., 2009)

ocellus rhabdomere | variable

(Mishra et al., 2012)

oogenesis stage S8 & adult stage | female

follicle cell | apical

(Talamillo et al., 2013)

adult stage | female oogenesis stage S8 -- S10

(Gunawan et al., 2013)

oogenesis

follicle cell

(Pacquelet and Rorth, 2005)

(Pacquelet and Rorth, 2005)

spermatogenesis

hub cell

(Voog et al., 2008)

cyst cell of testis

(Voog et al., 2008)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult head

• membrane

(Aradska et al., 2015)

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

shg protein is restricted to the apical portion of cell-cell contacts in ectodermal epithelia, in a region distinct from that of Fas3 protein (a marker for septate junction) localization.

(Apitz and Salecker, 2015, Uemura et al., 1996)

In ocelli, shg is concentrated at the distal and proximal ends of rhabdomeres.

(Mishra et al., 2012)

In stage 13 embryos shg is expressed in Malpighian tubule Type II (stellate) cells, particularly those that contact the tubule lumen but is lower than in the neighboring Malpighian tubule Type I (principal) cells. All Malpighian tubule Type II cells contact the luminal surface of the tubules in mid stage 14 and express high levels of shg as well as crb, baz, and dlg1.

(Campbell et al., 2010)

At the early third instar, secondary axon tracts form bundles of 20 to 50 fibers traversing the cortex and reaching the cortex-neuropile boundary. All early fibers express shg. In later third instar larvae, these axon tracts have grown and matured and no longer express shg. Late born, immature fibers grow at the center of these tracts and these younger fibers express shg.

(Fung et al., 2009)

shg protein concentrates at hub cell junctions. It is expressed in cyst cells and strongly enriched in the hub.

(Voog et al., 2008)

shg protein is concentrated at the apical portion of cell-cell contacts in differentiated epithelial layers.

(Li et al., 2007, Oda et al., 1994)

shg is expressed in the anterior cluster of somatic gonadal precursor cells in the stage 17 embryonic gonad. It is also expressed in the adult hub.

(Le Bras and Van Doren, 2006)

PPO1 protein is localized to maturing crystal cells in the lymph gland cortical zone.

(Jung et al., 2005)

shg is localized to the adherens junctions of the cell-cell interfaces of all cells of the retina.

(Hayashi and Carthew, 2004)

In stage 13 embryos,shg protein expression is detected on the cell membrane of both somatic germline precursor cells as well as the germline cells in both males and females. This localization is concurrent with the processes of ensheathment and coalescence of the developing gonad. In stage 17 male embryos, shg protein is concentrated in the anterior of the gonad in the region corresponding to the testes hub.

(Jenkins et al., 2003)

shg protein was first observed along cell-cell boundaries at the cellular blastoderm stage. At germ band elongation, it is present homogeneously in the epidermal ectoderm of the embryo. shg protein expression persists in the ectodermal epithelia including the epidermis, salivary glands, Malpighian tubules, hindgut and tracheal system throughout embryogenesis.

(Oda et al., 1994)

Marker for

adherens junction

(Hayashi and Carthew, 2004)

Subcellular Localization

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Yashiro et al., 2014, Haruta et al., 2010)

located_in apical junction complex

inferred from direct assay

(Pilot et al., 2006)

part_of catenin complex

inferred from direct assay

(Menzel et al., 2008)

located_in cell cortex

inferred from direct assay

(Bardet et al., 2013)

located_in filopodium

inferred from direct assay

(Liu et al., 2008)

located_in integral component of plasma membrane

inferred from direct assay

(Mavrakis et al., 2009, Oda et al., 1994)

located_in plasma membrane

inferred from direct assay

(assigned by UniProt )

(Melani et al., 2008)

located_in recycling endosome

inferred from direct assay

(de Madrid et al., 2015)

located_in spot adherens junction

inferred from direct assay

(Harris and Peifer, 2004)

Expression Deduced from Reporters

Reporter: P{PZ}shg¹⁰⁴⁶⁹

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

wandering third instar larval stage

embryonic/larval tracheal section

(Meister and Braun, 1995.10)

imaginal disc

(Meister and Braun, 1995.10)

embryonic/larval brain

(Meister and Braun, 1995.10)

third segment of antenna

(Vosshall, 1998.8.10)

lamina

(Vosshall, 1998.8.10)

Reporter: P{shg-lacZ.1.3}

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S8 -- S10 & adult stage | female

wandering third instar larval stage

(Gunawan et al., 2013)

Reporter: P{ST.lexA::HG}shg^SE205

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\shg in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\shg

View exonic expression by tissue for Dmel\shg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003391

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37386/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003391

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003391

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003391

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3722

Flygut - An atlas of the Drosophila adult midgut

FBgn0003391

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\shg

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 66 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 80 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of shg

Transgenic constructs containing regulatory region of shg

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(2R)BSC462

(Christensen et al., 2008.4.15)

Df(2R)BSC814

(Kahsai et al., 2016, Christensen et al., 2009.5.6)

Df(2R)E2

(Kraut, 2000.8.14, Cox et al., 1996, Uemura et al., 1996)

Df(2R)Pu-D17

(Spradling et al., 1999, Tepass et al., 1996, Uemura et al., 1996, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2R)017

(Cox et al., 2000)

Df(2R)D4

(Kraut, 2000.8.14, Kraut and Campos-Ortega, 1996)

Df(2R)XE3030

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^NP1548

shg^UAS.cUa

lethal, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

lethal (with Df(2R)BSC814)

shg²

lethal (with shg²)

lethal (with shg^2DN.GFP)

shg²

lethal (with shg^E17D)

shg²

lethal (with shg^S4A.GFP)

shg²

lethal (with shg^ΔS.GFP)

shg²

lethal (with shg^{ΔS.α-Cat.GFP})

shg²

lethal (with shg^ΔβS.GFP)

shg²

lethal (with shg^{ΔβS.α-Cat.GFP})

shg²

lethal | recessive

lethal - all die before end of larval stage

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

shg^GD14421

lethal - all die during embryonic stage

lethal - all die during embryonic stage, with Scer\GAL4^VP16.arm

lethal - all die during embryonic stage | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

shg^GD2659

viable, with Scer\GAL4^pnr-MD237

shg^GD2659

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal cell adhesion | late third instar larval stage | somatic clone

shg¹

abnormal cell adhesion | maternal effect

abnormal cell adhesion | oogenesis, with Scer\GAL4^upd1.PU

shg^HMS00693

abnormal cell adhesion | third instar larval stage, with Scer\GAL4^dpp.PU

shg^UAS.cSa

abnormal cell migration

shg^k03401

abnormal cell migration, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

abnormal cell migration, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, shg^GD14421, shg^HMS00693

shg^KK103334

abnormal cell migration, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, shg^GD14421, shg^KK103334

shg^HMS00693

abnormal cell migration, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, shg^HMS00693, shg^KK103334

shg^GD14421

abnormal cell migration, with Scer\GAL4^slbo.2.6

shg^GD14421

abnormal cell migration, with Scer\GAL4^slbo.2.6, shg^GD14421, shg^HMS00693

shg^KK103334

abnormal cell migration, with Scer\GAL4^slbo.2.6, shg^GD14421, shg^KK103334

shg^HMS00693

abnormal cell migration, with Scer\GAL4^slbo.2.6, shg^HMS00693, shg^KK103334

shg^GD14421

abnormal cell migration | germline clone

shg^R69

abnormal cell migration | maternal effect

abnormal cell migration | oogenesis | oogenesis, with Scer\GAL4^slbo.2.6

shg^HMS00693

abnormal cell migration | somatic clone

shg^R69

abnormal cell migration | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

abnormal cell migration | third instar larval stage, with Scer\GAL4^dpp.PU

abnormal cell polarity

shg^R6

abnormal cell polarity, with Scer\GAL4^hs.2sev

shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity, with Scer\GAL4^hs.2sev, shg¹

shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity, with Scer\GAL4^hs.2sev, shg²

shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity, with Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity, with Scer\GAL4^hs.2sev, shg^ex.UAS

shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity, with Scer\GAL4^hs.2sev, shg^k03401

shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity, with Scer\GAL4^hs.2sev, shg^Δβ.UAS

shg^{dCR3h.UAS.sgGFP}

abnormal cell polarity | cell autonomous | pupal stage | somatic clone

abnormal cell polarity | cell non-autonomous | somatic clone

shg^k03401

abnormal cell shape | larval stage, with Scer\GAL4^nrv2.PS

shg^ex.UAS

abnormal cell shape | recessive

shg^g119

abnormal cell shape | somatic clone

abnormal cell shape | somatic clone | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

abnormal cell shape | third instar larval stage, with Scer\GAL4^e22c

shg^GD14421

abnormal immune response | adult stage | dominant

shg^GE13814

abnormal mitotic cell cycle | second instar larval stage, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

abnormal neuroanatomy | late third instar larval stage | somatic clone

shg¹

abnormal size | larval stage, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

abnormal size | larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

abnormal size | larval stage | somatic clone

shg^R69

abnormal size | somatic clone | third instar larval stage

abnormal wound healing, with Scer\GAL4^{VP16.mat.αTub67C}

shg^{Ubi-p63E.sgGFP}

abnormal wound healing | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^UAS.sgGFP

abnormal wound healing | maternal effect | recessive

shg^k03401

decreased cell number, with Scer\GAL4^NP7397

shg^NIG.3722R

decreased cell number | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

decreased cell number | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

decreased cell number | dominant | progressive

decreased cell number | larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

decreased cell number | third instar larval stage, with Scer\GAL4^C587

shg^{dsRNA.UAS.cVa}

decreased occurrence of cell division | larval stage, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

decreased occurrence of cell division | larval stage, with Scer\GAL4^hs.PH

shg^ex.UAS

flightless, with Scer\GAL4^Mef2.PR

shg^GD14421

increased cell death

shg²

increased cell death | late third instar larval stage | somatic clone

shg¹

increased cell number | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

increased cell size | third instar larval stage, with Scer\GAL4^e22c

shg^GD14421

some die during embryonic stage

some die during embryonic stage, with Scer\GAL4^VP16.arm

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

shg^GD14421

visible, with Scer\GAL4^en.PU

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

visible, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

visible, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

visible, with Scer\GAL4^vg.PM

shg^UAS.cOa

visible | recessive

shg^R6

wild-type

shg^{Ubi-p63E.sgGFP}

Phenotype manifest in

Allele

abdominal segment 8 anterior compartment | pupal stage, with Scer\GAL4^Abd-B-LDN

shg^UAS.sgGFP

abdominal segment 8 anterior compartment | pupal stage | somatic clone, with Scer\GAL4^Act.PU

shg^HMS00693

actin filament | embryonic stage

shg^g317

adherens junction | embryonic stage

shg²

adherens junction | embryonic stage, with shg^{DEΔ734-1316.Ubi.EGFP}

shg^R69

adherens junction | embryonic stage, with shg^R69

shg^{DEΔ734-1316.Ubi.EGFP}

adherens junction | late third instar larval stage | somatic clone

shg¹

adherens junction | pupal stage, with Scer\GAL4^Abd-B-LDN

shg^UAS.sgGFP

adherens junction | pupal stage | somatic clone, with Scer\GAL4^Act.PU

shg^HMS00693

adherens junction | somatic clone | third instar larval stage

shg^g317

anterior protocerebral neuromere, with Scer\GAL4^hs.PH

shg^ex.UAS

apical part of cell | cell autonomous | pupal stage | somatic clone

Bolwig organ

shg²

Bolwig organ, with Scer\GAL4^da.G32

shg^UAS.cSa

border follicle cell | germline clone

border follicle cell, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

border follicle cell, with Scer\GAL4^slbo.2.6

border follicle cell, with Scer\GAL4^upd1.PU

shg^HMS00693

border follicle cell & filopodium | somatic clone

shg¹

border follicle cell & filopodium | somatic clone | cell non-autonomous

shg¹

shg^R69

border follicle cell | somatic clone

cardioblast

cardioblast & adherens junction

shg^k03401

cell body glial cell, with Scer\GAL4^hs.PH

shg^ex.UAS

centripetal follicle cell

shg²

centripetal follicle cell | germline clone

shg^R69

centripetal follicle cell | somatic clone

shg^R69

cone cell, with Scer\GAL4^GMR.PF

shg^UAS.sgGFP

cone cell | somatic clone

shg^R69

cone cell | somatic clone, with Scer\GAL4^Act5C.PI

shg^UAS.sgGFP

cyst progenitor cell

shg¹

cyst progenitor cell | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

cyst progenitor cell | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

denticle & embryonic epidermis | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

denticle | ectopic | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

denticle | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

egg

shg^{Ubi-p63E.sgGFP}

egg | germline clone

egg chamber

shg^k03401

egg chamber | somatic clone

shg^R69

embryo | gastrula stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle, with Scer\GAL4^VP16.arm

shg^UAS.cSa

embryonic/first instar larval cuticle & embryonic head

shg^g119

embryonic/first instar larval cuticle | dorsal, with Scer\GAL4^arm.PS

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

embryonic/first instar larval cuticle | embryonic stage

embryonic/first instar larval cuticle | lateral

embryonic/first instar larval cuticle | ventral

embryonic/larval brain, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

embryonic/larval brain, with Scer\GAL4^hs.PH

shg^ex.UAS

embryonic/larval cell body glial cell, with Scer\GAL4^nrv2.PS

shg^ex.UAS

embryonic/larval dorsal tracheal branch | embryonic stage (with shg²)

shg^E17B

embryonic/larval dorsal tracheal branch | embryonic stage (with shg^E17B)

shg²

embryonic/larval dorsal vessel

shg^J2B2

embryonic/larval epidermis | third instar larval stage, with Scer\GAL4^e22c

shg^GD14421

embryonic/larval hindgut

embryonic/larval hindgut (with shg^R69)

shg^R758

embryonic/larval hindgut (with shg^R758)

shg^R69

embryonic/larval salivary gland, with Scer\GAL4^AB1

shg^UAS.sgGFP

embryonic/larval tracheal dorsal trunk

embryonic/larval tracheal dorsal trunk (with shg²)

shg^E17B

embryonic/larval tracheal dorsal trunk (with shg^E17B)

shg²

embryonic/larval tracheal section

shg^R69

embryonic/larval tracheal system

embryonic/larval tracheal system, with Scer\GAL4^btl.PS

shg^AAA-JXT.UAS

embryonic epidermis

embryonic epidermis, with Scer\GAL4^da.G32

shg^ex.UAS

embryonic epidermis, with Scer\GAL4^{VP16.mat.αTub67C}

embryonic epidermis & embryonic head

embryonic epidermis | germline clone | maternal effect

shg^S4A.GFP

embryonic epidermis | somatic clone, with Scer\GAL4^αTub84B.PP

shg^UAS.cSa

embryonic head

embryonic head, with shg^{DEΔ734-1316.Ubi.EGFP}

shg^R69

embryonic head, with shg^{DEΔ833-1316.Ubi.EGFP}

shg^R69

embryonic head, with shg^R69

embryonic head & embryonic/first instar larval cuticle

embryonic head epidermis

embryonic optic lobe primordium

shg²

embryonic optic lobe primordium, with Scer\GAL4^da.G32

shg^UAS.cSa

embryonic trachea & cortical actin cytoskeleton

shg²

embryonic ventral epidermis

embryonic ventral epidermis, with shg^{DEΔ833-1316.Ubi.EGFP}

shg^R69

embryonic ventral epidermis, with shg^R69

shg^{DEΔ833-1316.Ubi.EGFP}

endoderm

epithelial cell

epithelial cell, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

epithelial cell | embryonic stage

epithelial cell | embryonic stage | germline clone | maternal effect

shg^S4A.GFP

epithelial cell | somatic clone

shg^R69

epithelial cell | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

epithelial cell | third instar larval stage, with Scer\GAL4^dpp.PU

epithelium | pupal stage, with Scer\GAL4^Abd-B-LDN

shg^UAS.sgGFP

epithelium | pupal stage | somatic clone, with Scer\GAL4^Act.PU

shg^HMS00693

eye, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

eye disc morphogenetic furrow, with Scer\GAL4^dpp.blk1

shg^DN.UAS

fascicle, with Scer\GAL4^elav-C155

shg^ex.UAS

fat body/gonad primordium

shg^g317

fat body/gonad primordium, with Scer\GAL4^VP16.nos.UTR

shg^UAS.cSa

fat body/gonad primordium | male

shg^g317

female germline cyst | progressive

female germline cyst | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

female germline stem cell | germline clone

shg^R69

female germline stem cell | germline clone, with Scer\GAL4^VP16.nos.UTR

shg^{UASp.Tag:FLAG}

female germline stem cell | germline clone | progressive

shg^KK103334

female germline stem cell | progressive

female germline stem cell | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

female germline stem cell | somatic clone

shg^R69

flight muscle cell, with Scer\GAL4^Mef2.PR

shg^GD14421

follicle cell, with shg¹

shg^{Δβ.αTub84B}

follicle cell, with shg^{Δβ.αTub84B}

shg¹

follicle cell | somatic clone

shg¹

follicle stem cell | somatic clone

germarium | progressive

germarium | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

germarium cap cell | progressive, with Scer\GAL4^nos.PU

shg^{UASp.Tag:FLAG}

germinal proliferation center hub, with Scer\GAL4^C587

shg^{dsRNA.UAS.cVa}

germline cell

shg²

germline cell | embryonic stage | maternal effect

shg^g317

germline cell | maternal effect

gonad | embryonic stage

shg^R69

gonad | embryonic stage (with shg²)

shg^R64a

gonad | embryonic stage (with shg^19.7)

shg^81.05

gonad | embryonic stage (with shg^81.05)

shg^19.7

gonad | embryonic stage (with shg^R64a)

shg²

gonadal sheath proper primordium

gonadal sheath proper primordium, with Scer\GAL4^VP16.nos.UTR

shg^UAS.cSa

gonadal sheath proper primordium | male

shg^g317

head

head, with Scer\GAL4^VP16.arm

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

hemocyte | adult stage

shg^GE13814

histoblast | somatic clone

shg^{Ubi-p63E.sgGFP}

histoblast nest | somatic clone

shg^{Ubi-p63E.sgGFP}

hub cell | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

hub cell | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

imaginal disc | somatic clone

shg^R69

indirect flight muscle cell, with Scer\GAL4^Mef2.PR

shg^GD14421

interommatidial bristle | ectopic, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

lamina cortex & satellite glial cell, with Scer\GAL4^nrv2.PS

shg^ex.UAS

larval outer optic anlage | late third instar larval stage | somatic clone

shg¹

male accessory gland secondary cell, with Scer\GAL4^NP7397

shg^NIG.3722R

male genitalia, with Scer\GAL4^Abd-B-LDN

male genitalia, with Scer\GAL4^NP1548

shg^KK103334

male germline stem cell

shg¹

male germline stem cell, with Scer\GAL4^C587

shg^{dsRNA.UAS.cVa}

male germline stem cell | adult stage, with Scer\GAL4^upd1.PU

shg^{dNc.UAS.sgGFP}

male germline stem cell | adult stage, with Scer\GAL4^VP16.nos.UTR

shg^{dNc.UAS.sgGFP}

male germline stem cell | germline clone

shg^R69

male germline stem cell | somatic clone, with Scer\GAL4^{VP16.nos.-FRT}

shg^UAS.sgGFP

Malpighian tubule

mesothoracic tergum | cell autonomous | pupal stage | somatic clone

microchaeta & mesothoracic tergum, with Scer\GAL4^pnr-MD237

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

microchaeta | supernumerary & mesothoracic tergum, with Scer\GAL4^pnr-MD237

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

microtubule & adherens junction, with Scer\GAL4^btl.PS

shg^AAA-JXT.UAS

myofibril, with Scer\GAL4^Mef2.PR

shg^GD14421

neuroblast, with Scer\GAL4^gcm-rA87.C

shg^ex.UAS

neuroblast, with Scer\GAL4^hs.PH

shg^ex.UAS

neuroblast, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

neuroblast | ectopic, with Scer\GAL4^elav-C155

shg^ex.UAS

neurogenic region

shg^g317

neurogenic region, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

neuropil, with Scer\GAL4^hs.PH

shg^ex.UAS

neuropil associated CNS glial cell, with Scer\GAL4^hs.PH

shg^ex.UAS

nucleus | blastoderm stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

nurse cell | germline clone

shg¹

nurse cell ring canal | germline clone

shg¹

ommatidial precursor cluster | cell non-autonomous | somatic clone

shg^k03401

ommatidium

shg^R6

ommatidium, with Scer\GAL4^GMR.PF

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

ommatidium, with Scer\GAL4^hs.2sev

ommatidium, with Scer\GAL4^hs.2sev, shg¹

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg²

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^ex.UAS

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^k03401

shg^{dCR3h.UAS.sgGFP}

ommatidium, with Scer\GAL4^hs.2sev, shg^Δβ.UAS

shg^{dCR3h.UAS.sgGFP}

oocyte

oocyte | cell non-autonomous | somatic clone, with Scer\GAL4^Act5C.PP

shg^UAS.cSa

oocyte | germline clone

oocyte | somatic clone

optic lobe neuroepithelial cell | late third instar larval stage | somatic clone

shg¹

organism | embryonic stage

shg^k03401

ovary | germline clone

plasma membrane | blastoderm stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

posterior crossvein, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

posterior spiracle primordium

shg²

presumptive embryonic/larval nervous system

shg²

presumptive embryonic/larval peripheral nervous system

shg^g317

presumptive embryonic/larval tracheal system

shg^g119

primary pigment cell | somatic clone

shg^R69

sarcomere, with Scer\GAL4^Mef2.PR

shg^GD14421

scutum, with Scer\GAL4^arm.PS

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

sensory mother cell, with Scer\GAL4^neur-P72

shg^{dCPc3.UAS.sgGFP}

sensory mother cell | somatic clone

spindle, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

stomatogastric nervous system | embryonic stage

shg^g317

tracheal branch primordium

tracheal system

shg²

tracheolar cell

shg²

ventral furrow, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

ventral furrow, with shg^{DEΔ734-1316.Ubi.EGFP}

shg^R69

ventral furrow, with shg^R69

shg^{DEΔ734-1316.Ubi.EGFP}

visual primordium

shg^g317

wing

wing, with Scer\GAL4^arm.PS

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing, with Scer\GAL4^en-e16E

wing | posterior, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing blade, with Scer\GAL4^en.PU

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing blade | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

shg^KK103334

wing blade posterior compartment, with Scer\GAL4^en-e16E

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

shg^UAS.cSa

wing disc | somatic clone | third instar larval stage

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

wing disc | third instar larval stage, with Scer\GAL4^dpp.PU

wing hair | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

shg^KK103334

wing margin, with Scer\GAL4^en-e16E

wing margin, with Scer\GAL4^vg.PM

wing margin | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

shg^KK103334

wing margin bristle, with Scer\GAL4^en-e16E

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

zonula adherens | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

shg^ex.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CDH20

1 of 15

Yes

Hsap\CDHR2

1 of 15

Yes

Hsap\DSG1

1 of 15

Yes

Hsap\FAT1

1 of 15

Yes

Hsap\FAT2

1 of 15

Yes

Hsap\FAT3

1 of 15

Yes

Hsap\FAT4

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cdh20

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Dsg1b

1 of 15

Yes

Mmus\Dsg1c

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (18)

Rnor\Cdh1

1 of 13

Yes

Rnor\Cdh2

1 of 13

Yes

Rnor\Cdh6

1 of 13

Yes

Rnor\Cdh7

1 of 13

Yes

Rnor\Cdh8

1 of 13

Yes

Rnor\Cdh9

1 of 13

Yes

Rnor\Cdh10

1 of 13

Yes

Rnor\Cdh11

1 of 13

Yes

Rnor\Cdh12

1 of 13

Yes

Rnor\Cdh18

1 of 13

Yes

Rnor\Cdh19

1 of 13

Yes

Rnor\Cdh20

1 of 13

Yes

Rnor\Cdh22

1 of 13

Yes

Rnor\Cdh24

1 of 13

Yes

Rnor\Fat1

1 of 13

Yes

Rnor\Fat2

1 of 13

Yes

Rnor\Fat3

1 of 13

Yes

Rnor\Fat4

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\LOC100493382

1 of 12

Yes

Xtro\LOC100494953

1 of 12

Yes

Danio rerio (Zebrafish) (7)

Drer\si:ch211-186j3.6

3 of 15

Yes

Drer\si:dkey-22o22.2

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\hmr-1

3 of 15

Yes

Cele\cdh-1

1 of 15

Cele\cdh-9

1 of 15

Cele\cdh-12

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

kug

1 of 10

stan

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

shg^UAS.cSa

model of cancer

CEA

(Shen et al., 2014)

shg^k03401

model of carcinoma

CEA with Ras85D^V12.UAS

(Igaki et al., 2006)

shg^NIG.3722R

model of prostate cancer

CEA

(Ito et al., 2014)

shg^{i.UAS.Tag:SS(aos),Tag:MYC}

model of cancer

CEA

(Shen et al., 2014)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

shg^UAS.cOa

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib¹

(Pagliarini and Xu, 2003)

shg^UAS.cSa

DOES NOT ameliorate cancer

modeled by bi^UAS.cPa

(Shen et al., 2014)

model of cancer

is NOT ameliorated by bi^UAS.cBa

(Shen et al., 2014)

is NOT ameliorated by bi^UAS.cPa

(Shen et al., 2014)

shg^{dCR4h.UAS.sgGFP}

ameliorates familial adenomatous polyposis 1

modeled by Apc2^g10, Apc^Q8

(Ngo et al., 2020)

shg^NIG.3722R

exacerbates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

shg^UASp.cUa

ameliorates cancer

modeled by Myc^αTub84B.PBb

(Levayer et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bead aggregation assay, fluorescence microscopy, inferred by author

(Nishiguchi and Oda, 2021, Nishiguchi et al., 2016, Lovegrove et al., 2006)

shg - Egfr

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Dumstrei et al., 2002)

shg - Hakai

(Kaido et al., 2009)

shg - Inx2

anti bait coimmunoprecipitation, western blot, two hybrid

(Bauer et al., 2004)

shg - Inx3

anti tag coimmunoprecipitation, western blot

(Giuliani et al., 2013)

shg - Mmp1

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

shg - Mmp2

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

shg - Myo10A

pull down, autoradiography, anti bait coimmunoprecipitation, western blot, two hybrid

(Liu et al., 2008)

shg - Myo31DF

anti tag coimmunoprecipitation, western blot

(Petzoldt et al., 2012)

shg - N

(Sasaki et al., 2007)

shg - Src42A

(Takahashi et al., 2005)

shg - baz

pull down, molecular weight estimation by staining

(Bulgakova et al., 2013, Harris and Peifer, 2005)

shg - cno

(Sawyer et al., 2009)

shg - lqfR

anti tag coimmunoprecipitation, western blot

(Lee and Fischer, 2012)

shg - p120ctn

anti tag coimmunoprecipitation, western blot, pull down, autoradiography, two hybrid

(Liu et al., 2008, Myster et al., 2003)

shg - wrapper

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Slováková and Carmena, 2011)

shg - α-Cat

(Desai et al., 2013, Iwai et al., 1997, Oda et al., 1994)

RNA-protein

Physical Interaction

Assay

References

shg - Fmr1

clip-seq, anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Buddika et al., 2021)

shg - Hrb98DE

nucleic acid uv cross-linking assay, tag visualisation, anti bait coimmunoprecipitation, reverse transcription pcr, quantitative reverse transcription pcr, electrophoretic mobility shift assay

(Ji and Tulin, 2016, Ji and Tulin, 2012)

shg - aub

iclip, partial RNA sequence identification

(Ma et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

AGO1

(Kataoka et al., 2001)

suppressible

AGO1

(Kataoka et al., 2001)

enhanceable

(Mirkovic and Mlodzik, 2006, Bauer et al., 2000, Greaves et al., 1999, Waltzer and Bienz, 1998)

suppressible

(Kataoka et al., 2001)

enhanceable

brm

(Barker et al., 2001)

enhanceable

btl::Egfr

(Dumstrei et al., 2002)

enhanceable

CadN

(Mirkovic and Mlodzik, 2006)

suppressible

Cdk1

(Greaves et al., 1999)

suppressible

crb

(Greaves et al., 1999)

suppressible

(Tepass et al., 1996)

Vang|shg

enhanceable

dgo

(Mirkovic and Mlodzik, 2006)

enhanceable

dgo

(Mirkovic and Mlodzik, 2006)

suppressible

dlg1

(Greaves et al., 1999)

suppressible

(Greaves et al., 1999)

enhanceable

dsh

(Greaves et al., 1999)

shg|Ras85D

enhanceable

egr

(Igaki et al., 2006)

suppressible

Fas3

(Greaves et al., 1999)

suppressible

(Greaves et al., 1999)

Ras85D|shg

suppressible

hep

(Igaki et al., 2006)

enhanceable

Jafrac1

(Degennaro et al., 2011)

suppressible

l(2)dC9

(Greaves et al., 1999)

suppressible

l(3)09291

(Greaves et al., 1999)

suppressible

lilli

(Greaves et al., 1999)

enhanceable

Mad

(Cordero et al., 2007)

enhanceable

mor

(Barker et al., 2001)

suppressible

Myo61F

(Petzoldt et al., 2012)

suppressible

(Tepass et al., 1996)

suppressible

nej

(Waltzer and Bienz, 1998)

suppressible

nkd

(Greaves et al., 1999)

enhanceable

p120ctn

(Myster et al., 2003)

suppressible

Pak

(Lee and Thomas, 2011)

enhanceable

pan

(Barker et al., 2001)

enhanceable

pont

(Bauer et al., 2000)

suppressible

rept

(Bauer et al., 2000)

enhanceable

Rho1

(Mirkovic and Mlodzik, 2006, Fox et al., 2005)

suppressible

(Fox et al., 2005)

suppressible

(Dumstrei et al., 2002)

suppressible

sdt

(Greaves et al., 1999)

suppressible

sgg

(Greaves et al., 1999)

suppressible

shg::Mmus\Cdh1

(Pacquelet and Rorth, 2005)

suppressible

shg::Rnor\Cd2::α-Cat

(Pacquelet and Rorth, 2005)

suppressible

stg

(Greaves et al., 1999)

enhanceable

tkv

(Cordero et al., 2007)

suppressible

Traf4

(Mathew et al., 2011)

suppressible

tws

(Greaves et al., 1999)

enhanceable

tws

(Bajpai et al., 2004)

suppressible

tyn

(Greaves et al., 1999)

enhanceable

Vang

(Mirkovic and Mlodzik, 2006)

dgo|shg

enhanceable

Vang

(Mirkovic and Mlodzik, 2006)

enhanceable

(Greaves et al., 1999)

suppressible

α-Cat::shg

(Pacquelet and Rorth, 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aop

suppressible

(Schober et al., 2005)

Apc|Apc2

enhanceable

(Wang et al., 2013)

enhanceable

(Greaves et al., 1999)

suppressible

(Loureiro and Peifer, 1998)

baz

enhanceable

(Shao et al., 2010)

suppressible

(Jin et al., 2008)

enhanceable

(Johnson et al., 2008)

cindr

suppressible

(Johnson et al., 2008)

crb

suppressible

(Chen et al., 2017, Flores-Benitez and Knust, 2015)

Csk

suppressible

(Vidal et al., 2006)

Csk

enhanceable

(Rudrapatna et al., 2014, Vidal et al., 2006)

CycE

suppressible

(Wang and Kalderon, 2009, Brumby et al., 2004)

suppressible

(Montrasio et al., 2007)

suppressible

(Morante et al., 2011)

foi

suppressible

(Mathews et al., 2006)

Hrb98DE

suppressible

(Ji and Tulin, 2012)

Hrb98DE|Parg

suppressible

(Ji and Tulin, 2012)

Inx2

suppressible

(Mukai et al., 2011)

jar

suppressible

(Geisbrecht and Montell, 2002)

jub

enhanceable

(Razzell et al., 2018)

suppressible

(Lim et al., 2015)

enhanceable

(Lim et al., 2015)

suppressible

(Tarayrah et al., 2015)

Lis-1

suppressible

(Chen et al., 2010)

miple1

suppressible

(Muñoz-Soriano et al., 2013)

mrva

suppressible

(Valoskova et al., 2019)

Myc

suppressible

(Levayer et al., 2015)

suppressible

(Tseng et al., 2014)

nmo

enhanceable

(Mirkovic et al., 2011)

p120ctn

enhanceable

(Larson et al., 2008, Myster et al., 2003)

Pak

suppressible

(Lee and Thomas, 2011)

Parg

suppressible

(Ji and Tulin, 2012)

enhanceable

(Sen et al., 2012)

suppressible

(Singh et al., 2006, Wang et al., 2006)

pyd

enhanceable

(Seppa et al., 2008)

Rac1

suppressible

(Pirraglia et al., 2006)

RanBPM

enhanceable

(Dansereau and Lasko, 2008)

Ras85D|scrib

suppressible

(Pagliarini and Xu, 2003)

RASSF8

enhanceable

(Langton et al., 2009)

raw

enhanceable

(Jemc et al., 2012)

raw

suppressible

(Jemc et al., 2012)

RhoL

suppressible

(Siekhaus et al., 2010)

enhanceable

(Brown and Freeman, 2003, Gaengel and Mlodzik, 2003)

sca

enhanceable

(Renaud and Simpson, 2001)

scra

suppressible

(Goldbach et al., 2010)

sdk

enhanceable

(Uechi and Kuranaga, 2019)

sdt

suppressible

(Chen et al., 2017)

suppressible

(Lee et al., 2016)

enhanceable

(Das et al., 2013)

suppressible

(Das et al., 2013)

enhanceable

(Shindo et al., 2008, Takahashi et al., 2005)

Src42A

suppressible

(Shindo et al., 2008)

Src64B

suppressible

(Fernández et al., 2014)

step

enhanceable

(West et al., 2017)

suppressible

(Gunawan et al., 2013)

tkv

enhanceable

(Cordero et al., 2007)

Vav

enhanceable

(Martín-Bermudo et al., 2015)

α-Cat

enhanceable