Drl, mda, medusa
transcription factor - homeodomain - Sine oculis and Eyes absent form a complex that regulates multiple steps in eye development - contributes to both cell and tissue fate specification, promotion of cell proliferation and suppression of apoptosis
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\so using the Feature Mapper tool.
Embryonic stage 6-7 expression of so is observed in the anlages of the optic lobe and the stomatogastric nervous system, and at the anterior lip of the ventral furrow.
GBrowse - Visual display of RNA-Seq signalsView Dmel\so in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Mutant embryos lack the corpus cardiacum and stomatogastric nervous system.
so and eya are two mediators of the eye inducing activity of ey. ey appears to induce the initial expression of so and eya in the eye disc. so and eya then participate in a positive feedback loop that regulates the expression of all three genes. In the embryonic head, however, so acts in parallel to ey and toy. The epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila.
Molecular and developmental analysis reveals so encodes a homeodomain-containing protein that is expressed and required in the unpatterned epithelium prior to morphogenesis. Analysis of mosaic clones supported an essential developmental role for so in eye development.
The mutant phenotype demonstrates the homeodomain containing so gene product is involved in the specification of the larval and adult visual system development during embryogenesis.
Observations of mutants support the proposal that axon fascicles can make at least some pathfinding decisions independently of their neighbours.
Mutants of so display a degraded ERG response. Eye development is also abnormal having structural defects within the rhabdomeres of the photoreceptor cells.