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General Information
Symbol
Dmel\Sod1
Species
D. melanogaster
Name
Superoxide dismutase 1
Annotation Symbol
CG11793
Feature Type
FlyBase ID
FBgn0003462
Gene Model Status
Stock Availability
Enzyme Name (EC)
Superoxide dismutase (1.15.1.1)
Gene Summary
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. (UniProt, P61851)
Contribute a Gene Snapshot for this gene.
Also Known As

SOD, superoxide dismutase, CuZnSOD, Cu-Zn SOD, cSOD

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:11,112,281..11,113,740 [-]
Recombination map
3-34
RefSeq locus
NT_037436 REGION:11112281..11113740
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000000113
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000000113
(assigned by GO_Central )
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000000113
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in peroxisome
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in peroxisome
inferred from sequence or structural similarity with HGNC:11179
inferred from sequence model
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Cu-Zn superoxide dismutase family. (P61851)
Catalytic Activity (EC)
Experimental Evidence
2 superoxide + 2 H(+) = O(2) + H(2)O(2) (1.15.1.1)
Predictions / Assertions
2 superoxide + 2 H(+) = O(2) + H(2)O(2) (1.15.1.1)
Summaries
Gene Group (FlyBase)
SUPEROXIDE DISMUTASES -
Superoxide dismutases are members of the oxidoreductase family that catalyze the oxidation of superoxide anion into hydrogen peroxide and molecular oxygen.
Protein Function (UniProtKB)
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
(UniProt, P61851)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Sod: Superoxide dismutase
The structural gene for Cu, Zn superoxide dismutase [Superoxide: superoxide oxidoreductase; SOD (EC 1.15.1.1.)], a homodimer of 15,000 subunit molecular weight that contains two Cu++ and two Zn++ per molecule. Enzyme catalyzes the dismutation of the superoxide anion, O2 -, to H2O2, which in turn is converted into H2O by catalase and peroxidases. Enzyme purified by Lee, Ayala, and Misra (J. Biol. Chem. 256: 8506-09); shows homology to homologous mammalian enzymes but does not crossreact with anti-bovine-erythrocyte-SOD antibodies; specific activity 1.5 times that of other species. Amino acid sequence determined by Lee, Friedman, and Ayala (1985, Arch. Biochem. Biophys. 241: 577-89); 151 amino acid residues with molecular weight 15,750. Enzyme levels show little variation during development; slight rise in activity during adulthood (Graf and Ayala, 1986, Biochem. Genet. 24: 153-68).
Sodn1
Originally recovered as a lethal mutation; homozygotes die in the process of eclosion; rare eclosing adults are completely sterile, are devoid of SOD activity and die within 2-3 days; however, some derived sublines show higher adult survival. Surviving homozygous males are sterile and homozygous females produce few if any offspring. Reduced life span and fertility attributed to reduced capacity of embryos, larvae, and pupae to protect developing preimaginal cells from O2 --initiated cytotoxic damage. Homozygotes hypersensitive to the O2 --radical-generating compound, paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride) and copper ions.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sod1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.42

Gene model reviewed during 5.44

Gene model reviewed during 5.46

Gene model reviewed during 6.28

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076229
735
153
Additional Transcript Data and Comments
Reported size (kB)

0.7-0.8 (northern blot)

0.7 (longest cDNA)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075958
15.7
153
6.06
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer.

(UniProt, P61851)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sod1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sod1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sod1
Transgenic constructs containing regulatory region of Sod1
Aberrations (Deficiencies and Duplications) ( 22 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
19  
3 of 15
No
No
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
2 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
11 of 13
Yes
Yes
3 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
12 of 12
Yes
Yes
3 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (4)
14 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
13 of 15
Yes
Yes
13 of 15
Yes
Yes
6 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
8 of 9
Yes
Yes
7 of 9
No
Yes
6 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
10 of 12
Yes
Yes
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190H9O )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D2P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DOJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DMG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OG2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
6 of 10
4 of 10
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 11 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Homodimer.
(UniProt, P61851 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-34
Cytogenetic map
Sequence location
3L:11,112,281..11,113,740 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
68A7-68A7
Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
68A-68A
(determined by in situ hybridisation)
68A4-68A9
(determined by in situ hybridisation)
68A8-68A9
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes

Mapped using closer markers than h and gv.

Mapping based on 151 h-gv recombinants.

Stocks and Reagents
Stocks (22)
Genomic Clones (25)
cDNA Clones (167)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Sod CG11793

    Source for identity of: Sod1 Sod

    Source for database merge of
    Additional comments
    Other Comments

    Overexpression of Sod significantly increases adult life span by up to 48%. Life span is affected by epistatic interactions between the transgene and alleles at other loci.

    The effect is clearly demonstrated using Scer\FRT constructs to control for genetic background effects.

    In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

    The rate of evolution of Sod has been investigated by comparing the Sod sequences of a number of different species.

    Sod activity has been measured in 6 different Drosophila strains.

    mRNA levels increase at adult day 5 in strain showing extended longevity phenotype (ELP).

    Mutations in Sod individuals, as in humans, cause neuropathology. Missense mutations expected to destabilise Sod subunits and dimer assembly significantly impair the activity of normal subunits in heterozygotes for a wild type allele, resulting in significantly lower enzyme activity than expected in heterozygotes.

    Mutations in Cat or Sod can accelerate the induction of Hsp70 genes during aging.

    The Dwil\Sod gene region has been cloned and sequenced, and compared with the comparable region from D.virilis, D.melanogaster and D.simulans.

    Transgenic flies carrying three copies of Sod+ and three copies of Cat+ exhibited as much as one third extension of life span, a longer mortality rate doubling time, a lower amount of protein oxidative damage and a delayed loss in physical performance. Results support the free radical hypothesis of aging.

    The extent to which a synthetic Drosophila-bovine transgene can compensate for loss of the endogenous Sod through the rescue of specific pleiotrophic phenotypes characteristic of a Sod null mutant is investigated.

    Over expression of Sod by 32-42% above normal, using a Sod transgene, has a minor/insignificant effect on life span of the flies and their ability to withstand experimental oxidative stress, induced by paraquat or hypoxia. Those transgenics that show a small increase in life span also show a improvement in resistance to hypoxia but not paraquat. The maximum life span is not affected.

    The more active Sod mutations are associated with postponed aging in laboratory stocks. No relationship was found with these mutations and a direct increase in life span or later fecundity, but this failure arose from a lack of experimental power. This negative result is not a pertinent refutation of the free radical mechanism of aging.

    Camo\Sod has been cloned, sequenced and compared with the Sod genes from a number of Drosophila species, including D.melanogaster.

    Comparison of CpG distribution in the coding region of 121 genes from six species supports the mCpG mutational hotspot explanation of CpG suppression in methylated species at position II-III and III-I.

    Phylogenetic trees for 25 Cu-Zn superoxide dismutases (including D.melanogaster Sod and Dvir\Sod) and 31 Mn/Fe superoxide dismutases (including D.melanogaster Sod2) have been constructed and the evolutionary rate of change for the two groups of proteins has been compared.

    Examination of the free radical theory of aging and the activity of Sod.

    The consequences of hypermorphic levels are studied using a duplication of a chromosomal region carrying Sod: confers increased resistance to ionizing radiation but decreased resistance to superoxide generating agents. Sod plays a vital role in maintaining normal adult longevity.

    Sod has been cloned and sequenced.

    The D.melanogaster Sod amino acid sequence has been compared to that of other species.

    The structural gene for Cu, Zn superoxide dismutase (SOD), a homodimer of 15,000 subunit molecular weight that contains two Cu++ and two Zn++ per molecule. Enzyme catalyzes the dismutation of the superoxide anion, O2-, to H2O2, which in turn is converted into H2O by catalase and peroxidases. Enzyme purified (Lee, Ayala and Misra, 1981); shows homology to homologous mammalian enzymes but does not crossreact with anti-bovine-erythrocyte-SOD antibodies; specific activity 1.5 times that of other species. Amino acid sequence determined by Lee, Friedman and Ayala (1985b); 151 amino acid residues with molecular weight 15,750. Enzyme levels show little variation during development; slight rise in activity during adulthood (Graf and Ayala, 1986).

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 56 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (72)
    Reported As
    Symbol Synonym
    Cu/Zn superoxide dismutase
    Cu2+/Zn2+SOD
    G
    SOD
    (de Aquino Silva et al., 2021, Fernandes et al., 2021, Habib et al., 2021, Portela et al., 2021, Silva et al., 2021, Koliada et al., 2020, Paithankar et al., 2020, Wen et al., 2020, Anet et al., 2019, Boulan et al., 2019, Deepashree et al., 2019, de Freitas Couto et al., 2019, Portela et al., 2019, Akinyemi et al., 2018, Leite et al., 2018, Occai et al., 2018, Pinal et al., 2018, Soares et al., 2018, Ecker et al., 2017, Macedo et al., 2017, Rajak et al., 2017, Sonani et al., 2017, Subramanian et al., 2017, Wang et al., 2017, Fogarty et al., 2016, Hu et al., 2016, Krishna and Muralidhara, 2016, Trindade de Paula et al., 2016, Araujo et al., 2015, Gupte, 2015, Jahromi et al., 2015, Jahromi et al., 2015, Jing et al., 2015, Krucek et al., 2015, Liu et al., 2015, Medina-Leendertz et al., 2014, Mora et al., 2014, Olalekan Abolaji et al., 2014, Prasad and Muralidhara, 2014, Valéria Soares de Araújo Pinho et al., 2014, Zemolin et al., 2014, Clancy and Birdsall, 2013, Lozinsky et al., 2013, Mehdi and Qamar, 2013, St Laurent et al., 2013, Fang et al., 2012, Monnier et al., 2012, Peng et al., 2012, Wang et al., 2012, Wu et al., 2012, Lushchak et al., 2011, Peng et al., 2011, Posgai et al., 2011, Rzezniczak et al., 2011, Ahamed et al., 2010, Huang et al., 2010, Liu and Lu, 2010, Lloyd and Taylor, 2010, Mockett et al., 2010, Singh et al., 2010, Grover et al., 2009, Gruenewald et al., 2009, Schriner et al., 2009, Baena-López et al., 2008, Mast et al., 2008, Pan and Xie, 2008, Siddique et al., 2008, Wang et al., 2008, Ahamed et al., 2007, Bayersdorfer et al., 2007, Pan et al., 2007, Magwere et al., 2006, Gupta et al., 2005, Deckert-Cruz et al., 2004, Passananti et al., 2004, Tyler et al., 2004, Helfand and Rogina, 2003, Spencer et al., 2003, Aigaki et al., 2002, Lerat et al., 2000, Lithgow and Andersen, 2000, Elia et al., 1999, Arking, 1998, Bassett et al., 1997, Johnson, 1997, Gaivao and Comendador, 1996, Orr and Sohal, 1994, Delaney, 1993.1.15, Tyler et al., 1993, Fleming et al., 1992, Hilliker et al., 1992, Lee et al., 1985)
    Sod1
    (Layalle et al., 2021, Shaposhnikov et al., 2021, Ueda et al., 2021, Ward and Moehring, 2021, Yang et al., 2021, Chen et al., 2020, Fujisawa et al., 2020, Gerlach and Herranz, 2020, Huang et al., 2020, Jeon et al., 2020, Li et al., 2020, Olufs et al., 2020, Pridie et al., 2020, Syal et al., 2020, Vásquez-Procopio et al., 2020, Wong et al., 2020, Anyagaligbo et al., 2019, Bayliak et al., 2019, Chaplot et al., 2019, Doktór et al., 2019, Evangelakou et al., 2019, Hughes and Simmonds, 2019, Krittika and Yadav, 2019, Li et al., 2019, Meltzer et al., 2019, Rohde et al., 2019, Su et al., 2019, Walters et al., 2019, Zhang et al., 2019, Anderson-Baron and Simmonds, 2018, Azuma et al., 2018, de Paula et al., 2018, Hill et al., 2018, Klimaczewski et al., 2018, Lee et al., 2018, Li et al., 2018, Oberacker et al., 2018, Sakakibara et al., 2018, Shaposhnikov et al., 2018, Stapper and Jahn, 2018, Webber et al., 2018, Chen et al., 2017, Jo and Imm, 2017, Wang et al., 2017, Gene Disruption Project members, 2016-, Sanz, 2016, Kopp et al., 2015, Lashmanova et al., 2015, Oka et al., 2015, Rovenko et al., 2015, Rovenko et al., 2015, Blackney et al., 2014, Lim et al., 2014, Mukherjee et al., 2014, Jahromi et al., 2013, Ranjini and Ramachandra, 2013, Chartier et al., 2012, Mandilaras and Missirlis, 2012, Monnier et al., 2012, Sun et al., 2012, Jones and Grotewiel, 2011, Söderberg et al., 2011, Kim et al., 2010, James et al., 2009, Martin et al., 2009, Wicks et al., 2009, Anderson et al., 2008, Kirby et al., 2008, Magwere et al., 2006, Anderson et al., 2005, Duttaroy et al., 2003, Hu et al., 2003, Missirlis et al., 2003, Missirlis et al., 2003, Wallace and Melov, 1998)
    To
    l(3)108
    Name Synonyms
    Complementation group G
    Cu, Zn superoxide dismutase
    Cu/Zn superoxide dismutase
    Cu/Zn-Superoxide dismutase
    Cu2+ Zn2+ superoxide dismutase
    Cu2+Zn2+ superoxide dismutase
    CuZn superoxide dismutase
    CuZn-superoxide dismutase
    CuZn-superoxide dismutase (SOD)1
    Mn superoxide dismutase
    Superoxidase dismutase
    Tetrazolium oxidase
    copper and zinc SOD
    copper-zinc superoxide
    copper-zinc superoxide dismutase
    cytoplasmic Cu/ZnSOD
    super oxide dismutase
    superoxide dismutases 1
    superoxide dismutatase
    superoxide-dismutase
    superoxido dismutase
    tetrazolium oxidase-1
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (612)