FlyBase Gene Report: Dmel\sr

General Information

Symbol

Dmel\sr

Species

D. melanogaster

Name

stripe

Annotation Symbol

CG7847

Feature Type

protein_coding_gene

FlyBase ID

FBgn0003499

Gene Model Status

Stock Availability

215 publicly available

Gene Summary

stripe (sr) encodes a transcription factor that induces the fate of tendon cells in the embryo as well as in the adult fly. It works upstream of tendon specific genes including Tsp, slow and Lrt. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:18,090,803..18,135,583 [+]

Recombination map

3-62

RefSeq locus

NT_033777 REGION:18090803..18135583

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004619861

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004619861

(assigned by GO_Central )

(Gaudet et al., 2011)

enables SUMO ligase activity

inferred from sequence or structural similarity with UniProtKB:P08152

(FlyBase Curators, 2008-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in central nervous system development

inferred from mutant phenotype

(de la Pompa et al., 1989)

involved_in ectoderm development

inferred from mutant phenotype

(Volohonsky et al., 2007)

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Dorfman et al., 2002)

inferred from genetic interaction with FLYBASE:bnl; FB:FBgn0014135

(Dorfman et al., 2002)

involved_in germ-band shortening

inferred from mutant phenotype

(Volohonsky et al., 2007)

involved_in muscle organ development

inferred from mutant phenotype

(de la Pompa et al., 1989)

involved_in somatic muscle development

inferred from mutant phenotype

(Volohonsky et al., 2007)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in pigment metabolic process

traceable author statement

(Calleja et al., 2002)

involved_in protein sumoylation

inferred from sequence or structural similarity with UniProtKB:P08152

(FlyBase Curators, 2008-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004619861

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

SUMO TRANSFERASES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

stripe (sr) encodes a transcription factor that induces the fate of tendon cells in the embryo as well as in the adult fly. It works upstream of tendon specific genes including Tsp, slow and Lrt. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
SUMO TRANSFERASES -: SUMO transferases catalyze the transfer of SUMO from either E2 or E3 enzyme to a substrate.

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

sr: stripe

Trident pattern on thorax replaced by broad light gray stripe at 25; stripe is dark at 18 or in the presence of heterozygous or homozygous b or e. Homozygotes are flightless (Levine and Wyman, 1973, Proc. Nat. Acad. Sci. USA 70: 1050-54) and show a reduction in size of a specific indirect flight muscle, the dorsal longitudinal muscle (DLM). The DLM is absent from sr/Df(3)sr adults. Early development of the indirect flight muscles is normal, but in the thirty-five-hour pupa the DLM begins to degenerate leading to its absence in adults (Costello and Wyman).

Summary (Interactive Fly)

transcription factor - zinc finger - involved muscle development - induces the fate of tendon cells in the embryo as well as in the adult fly - works upstream of tendon specific genes including Thrombospondin, the Efg-like domain protein Slowdown and Leucine-rich tendon-specific protein.

Interactive Fly

Gene Model and Products

Number of Transcripts

5

Number of Unique Polypeptides

4

Please see the JBrowse view of Dmel\sr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KGW2)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.54

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0083542

5757

1186

FBtr0083543

4543

906

FBtr0301615

3976

717

FBtr0330050

5757

1271

FBtr0344633

6377

906

Additional Transcript Data and Comments

Reported size (kB)

5.8, 4.5 (compiled cDNA)

(Frommer et al., 1996)

6.5, 5.0 (northern blot)

(Lee et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0082966

128.3

1186

7.65

FBpp0082967

99.0

906

8.06

FBpp0290830

76.6

717

7.92

FBpp0303083

137.5

1271

7.34

FBpp0310950

99.0

906

8.06

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

906 aa isoforms: sr-PB, sr-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

1180, 906 (aa)

(Frommer et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sr_1
sr_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

muscle attachment site

(Frommer et al., 1996)

epidermis | restricted

(Frommer et al., 1996)

embryonic stage 14 -- 17

muscle attachment site

(Lee et al., 1995)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & pupal stage

(Lee et al., 1995)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

muscle attachment site

(Frommer et al., 1996)

epidermis | restricted

(Frommer et al., 1996)

(Dilks and DiNardo, 2010)

(Dilks and DiNardo, 2010)

embryonic stage 13

tendon cell | precursor

(Lahaye et al., 2012)

embryonic stage 13 -- 16

lch5 cap attachment cell

(Inbal et al., 2004)

embryonic stage 15

muscle attachment site

(Piepenburg et al., 2000)

muscle attachment site of segment border muscle cell

(Piepenburg et al., 2000)

embryonic stage 16

lch5 ligament attachment cell

(Inbal et al., 2004)

scolopidial ligament cell | subset

(Inbal et al., 2004)

Additional Descriptive Data

sr is expressed in columns 2 and 5 in the prospective denticle field and in one additional column in the smooth field.

(Dilks and DiNardo, 2010)

sr protein expression is restricted to the nuclei of epidermal cells and is seen at muscle attachment sites. No expression is observed in muscles or muscle precursors. The antibodies used recognize both forms of sr protein.

(Frommer et al., 1996)

Marker for

(Enriquez et al., 2012)

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{GawB}sr^md710

Stage

Tissue/Position (including subcellular localization)

Reference

prepupal stage P3

(Laddada et al., 2019)

embryonic stage

(Swan et al., 2004)

chordotonal organ | subset

(Inbal et al., 2004)

lch5 cap attachment cell

(Inbal et al., 2004)

embryonic stage 16

scolopidial ligament cell | subset

(Inbal et al., 2004)

first instar larval stage -- second instar larval stage

(Subramanian et al., 2003)

third instar larval stage

wing disc | restricted

(Usui et al., 2004)

scutum | presumptive

(Usui et al., 2004)

tendon cell | precursor

(Soler et al., 2004)

ventral thoracic disc

(Soler et al., 2004)

(Laddada et al., 2019)

mesothoracic tergum | restricted

(Usui et al., 2004)

pupal stage P6 -- pharate adult stage P15

Comment: reference states >=26 hr APF

(Ghazi et al., 2000)

(Krzemien et al., 2012)

Reporter: P{sr-lacZ.1.9}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

cell | segment boundary

(Piepenburg et al., 2000)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sr in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sr

View exonic expression by tissue for Dmel\sr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003499

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42162/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003499

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003499

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003499

Flygut - An atlas of the Drosophila adult midgut

FBgn0003499

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 55 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sr

Transgenic constructs containing regulatory region of sr

Aberrations (Deficiencies and Duplications) ( 31 )

Inferred from experimentation ( 31 )

Gene duplicated in

(Oliver, 1937)

(Gailey and Hall, 1989)

Gene disrupted in

(Christensen et al., 2008.4.15)

(Cook et al., 2008.7.11)

(Bellen et al., 1992, Gailey and Hall, 1989)

(Beiman et al., 1996)

(Beiman et al., 1996)

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Frommer et al., 1996, Bellen et al., 1992, Gailey and Hall, 1989)

(Ryder, 2004.4.26)

(Bellen et al., 1992, Gailey and Hall, 1989)

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Bellen et al., 1992, Gailey and Hall, 1989)

(BDGP Project Members, 1994-1999)

(Beiman et al., 1996, Goubeaud et al., 1996, Bellen et al., 1992)

Df(3R)sr100.394

(Ward and Alexander, 1957)

(Ward and Alexander, 1957)

Df(3R)sr300.101

(Ward and Alexander, 1957)

(Bellen et al., 1992)

(Fernandes et al., 1996, Lee et al., 1995)

T(2;3)sr^100.312

(Ward and Alexander, 1957)

T(Y;3)sr^100.23

(Ward and Alexander, 1957)

Tp(3;3)sr^300.240

(Ward and Alexander, 1957)

Gene not disrupted in

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Gailey and Hall, 1989)

(Bellen et al., 1992, Gailey and Hall, 1989)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(3R)BSC510)

sr^{CR00452-TG4.1}

lethal | recessive

lethal - all die during embryonic stage | recessive

sr^G11

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

sr^GD1540

partially lethal - majority die, with Scer\GAL4^pnr-MD237

sr^GD1540

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sr^GD1540

viable, with Scer\GAL4^tin.CΔ4

sr^GD1540

Other Phenotypes

Allele

abnormal cell shape | embryonic stage, with Scer\GAL4^69B

sr^A.UAS

abnormal eye color

sr^T1-90E

flightless | recessive

sr¹

some die during embryonic stage | recessive

sr^G11

some die during pupal stage, with Scer\GAL4^pnr-MD237

sr^GD1540

visible, with Scer\GAL4^pnr-MD237

sr^GD1540

visible, with Scer\GAL4^sca-C253

sr^b.UAS

visible, with Scer\GAL4^sr-md710

sr^b.UAS

visible | recessive

Phenotype manifest in

Allele

abdominal 5 lateral transverse muscle cell | embryonic stage, with Scer\GAL4^h.6

sr^b.UAS

abdominal 5 ventral longitudinal muscle cell | embryonic stage, with Scer\GAL4^h.6

sr^b.UAS

abdominal 6 lateral transverse muscle cell | embryonic stage, with Scer\GAL4^h.6

sr^b.UAS

abdominal 6 ventral longitudinal muscle cell | embryonic stage, with Scer\GAL4^h.6

sr^b.UAS

abdominal 7 lateral transverse muscle cell | embryonic stage, with Scer\GAL4^h.6

sr^b.UAS

abdominal 7 ventral longitudinal muscle cell | embryonic stage, with Scer\GAL4^h.6

sr^b.UAS

adult muscle system

sr^B14.0

sr^VJ54rv1

dorsal medial indirect flight muscle cell

ectoderm, with Scer\GAL4^69B

sr^A.UAS

embryonic/larval dorsal tracheal branch

sr^G11

embryonic/larval dorsal tracheal branch (with Df(3R)DG4)

sr¹⁵⁵

embryonic/larval dorsal tracheal branch | increased number, with Scer\GAL4^69B

sr^UAS.cBa

embryonic/larval dorsal tracheal branch | increased number, with Scer\GAL4^btl.PS

sr^UAS.cBa

embryonic/larval ganglionic tracheal branch

sr^G11

embryonic/larval ganglionic tracheal branch (with Df(3R)DG4)

sr¹⁵⁵

embryonic/larval muscle system (with Df(3R)DG4)

sr¹⁵⁵

embryonic/larval somatic muscle cell

sr¹⁵⁵

embryonic/larval somatic muscle cell, with Scer\GAL4^en-e16E

embryonic/larval somatic muscle cell, with Scer\GAL4^hs.2sev

sr^b.UAS

embryonic/larval somatic muscle cell, with Scer\GAL4^ptc-559.1

embryonic/larval somatic muscle cell | ventral, with Scer\GAL4^sim.PS

sr^b.UAS

embryonic/larval tracheal dorsal trunk

sr^G11

embryonic/larval tracheal dorsal trunk (with Df(3R)DG4)

sr¹⁵⁵

embryonic/larval tracheal system

sr¹⁵⁵

embryonic/larval visceral tracheal branch (with Df(3R)DG4)

sr¹⁵⁵

embryonic somatic muscle cell, with Scer\GAL4^69B

embryonic somatic muscle cell | lateral, with Df(3R)DG4, Scer\GAL4^sim.PS

sr^UAS.cBa

germ band, with Scer\GAL4^69B

sr^A.UAS

lateral transverse muscle cell | embryonic stage, with Scer\GAL4^en-e16E

lateral transverse muscle cell | embryonic stage, with Scer\GAL4^ptc-559.1

sr^UAS.cBa

lch5 cap attachment cell (with Df(3R)DG4)

sr¹⁵⁵

lch5 ligament attachment cell (with Df(3R)DG4)

sr¹⁵⁵

sr^B14.0

mesothoracic tergum, with Scer\GAL4^pnr-MD237

sr^GD1540

mesothoracic tergum & chaeta, with Scer\GAL4^sca-C253

sr^b.UAS

mesothoracic tergum & microchaeta, with Scer\GAL4^sr-md710

sr^b.UAS

muscle attachment site

sr¹⁵⁵

somatic mesoderm

sr^P1

somatic muscle cell | embryonic stage, with Df(3R)DG4, Scer\GAL4^ptc-559.1

sr^UAS.cBa

somatic muscle cell of abdomen

sr^VJ54

sr^VJ54

visceral muscle fiber

sr¹⁵⁵

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

6 of 15

Yes

Yes

5 of 15

No

Yes

5 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

6 of 15

Yes

Yes

6 of 15

Yes

Yes

5 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (5)

5 of 13

Yes

Yes

5 of 13

Yes

Yes

4 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (9)

5 of 12

Yes

Yes

5 of 12

Yes

Yes

4 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (11)

7 of 15

Yes

Yes

5 of 15

No

Yes

4 of 15

No

Yes

3 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:ch211-117k10.3

1 of 15

No

No

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (5)

7 of 15

Yes

Yes

3 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (4)

2 of 15

Yes

Yes

2 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

Schizosaccharomyces pombe (Fission yeast) (3)

2 of 12

Yes

Yes

1 of 12

No

Yes

1 of 12

No

No

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

EGR2; early growth response 2

model of Charcot-Marie-Tooth disease type 4E

IEA

(FlyBase, 2019-)

model of Charcot-Marie-Tooth disease type 1D

IEA

(FlyBase, 2019-)

model of Charcot-Marie-Tooth disease type 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EGR2; early growth response 2

6 of 15

EGR1; early growth response 1

5 of 15

EGR3; early growth response 3

5 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

RNA-protein

Physical Interaction

Assay

References

pull down, western blot, anti tag western blot

(Nir et al., 2012, Israeli et al., 2007, Volohonsky et al., 2007, Nabel-Rosen et al., 2005, Nabel-Rosen et al., 1999)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Ghazi et al., 2000)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Usui et al., 2004)

enhanceable

(Ghazi et al., 2000)

enhanceable

(Dorfman et al., 2002)

suppressible

(Butí et al., 2014)

suppressible

(Maixner et al., 1998)

suppressible

(Usui et al., 2004)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67186

DroID - A comprehensive database of gene and protein interactions.

FBgn0003499

MIST (protein-protein) - An integrated Molecular Interaction Database

sr

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-62

Cytogenetic map

Sequence location

3R:18,090,803..18,135,583 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

90E4-90F1

Limits computationally determined from genome sequence between P{EP}cpo^EP3679 and P{EP}Dlc90F^EP3634

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

90E1-90E2

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

90E1-90E4

(determined by in situ hybridisation)

(Bellen and Kolodkin, 1993)

Experimentally Determined Recombination Data

Location

3-62

(FlyBase, 2016)

3-61.1

(Comeron et al., 2012)

3-62.0

Left of (cM)

Right of (cM)

r(αGPDH)

(King and McDonald, 1982)

Notes

Stocks and Reagents

Stocks (215)

Aberrations including deletions of this gene Aberrations including duplications of this gene

598

519

36533

w^*; P{UAS-sr.b.V}59

36534

w^*; P{UAS-sr.b.V}20.1

24223

w¹¹¹⁸; Mi{ET1}sr^MB04757

106000

105959

124432

w¹¹¹⁸; P{RS3}sr^UM-8233-3

125842

w¹¹¹⁸; P{RS5}sr^5-SZ-3026

126243

w¹¹¹⁸; P{RS5}sr^5-SZ-3943

v105282

P{KK107677}VIE-260B

v9921

w¹¹¹⁸; P{GD1540}v9921

More stocks available...

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE58041

Other clones

FI18283

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0003499

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0003499

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42162

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Frommer et al., 1996)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: sr CG7847

(Gong, 1999.11)

Source for database merge of

Source for merge of: sr l(3)06948b

(Beaton, 1999.12.12)

Additional comments

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

sr acts co-operatively with bnl to facilitate extension of tracheal branches.

(Dorfman et al., 2002)

sr is necessary and sufficient to initiate the developmental program of epidermal muscle attachment cells.

(Becker et al., 1997)

sr activity controls the expression of epidermal muscle attachment site-specific target genes in cells of ectodermal but not mesodermal origin. sr-expressing ectodermal cells generate long-range signals that interfere with the spatial orientation of elongating myotubes.

(Vorbruggen and Jackle, 1997)

Cloning and molecular characterisation of sr reveals that sr activity induces a subset of ectodermal cells to develop into muscle attachment sites and to provide spatial cues necessary to orient myotubes along the basal surface of the epidermis to their targeted attachment cells.

(Frommer et al., 1996)

sr gene product is required for apodeme development or muscle/apodeme attachment.

(Frommer et al., 1995)

sr plays a role in intercellular communication required for normal muscle development. sr mediates muscle development through its expression in cells that interact with developing muscle.

(Lee et al., 1995)

sr is expressed in the ectoderm at the future muscle attachment sites and may be required for apodeme differentiation to enable the correct targeting by the approaching myotubule.

(Volk et al., 1995)

The sr gene is expressed at the segment border of the embryo and mutants at the sr locus affect muscle patterning.

(Volk and Vijay Raghavan, 1994)

Mutants in sr specifically affect the dorsolateral muscles.

(de la Pompa et al., 1989)

Mutant individuals display a dark median stripe on the thorax.

(Duncan and Kaufman, 1975)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 67 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42162

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KGW2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KGW2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0003499

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0003499

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42162/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0003499

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sr_1
sr_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003499

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0003499

Flygut - An atlas of the Drosophila adult midgut

FBgn0003499

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42162

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004846

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7847

MARRVEL_MODEL - MARRVEL (model organism gene)

42162

modMine - A data warehouse for the modENCODE project

FBgn0003499

Linkouts

BioGRID - A database of protein and genetic interactions.

67186

DroID - A comprehensive database of gene and protein interactions.

FBgn0003499

DRSC - Results frm RNAi screens

FBgn0003499

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0003499

FlyMine - An integrated database for Drosophila genomics

FBgn0003499

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

sr

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG7847

(Hassan et al., 2018, Yamaguchi and Takashima, 2018, Hosono et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009)

Sr

(Poovathumkadavil and Jagla, 2020, Laddada et al., 2019, Hasson et al., 2017, Terhzaz et al., 2014, Enriquez et al., 2012, Patel et al., 2012, Egoz-Matia et al., 2011, Olguín et al., 2011, Jones, 2001)

SrB

(Enriquez et al., 2012)

Stripe

(Kent and Agrawal, 2020)

l(3)03999

l(3)06948

(Maixner et al., 1998)

l(3)06948b

sr

(Takakura et al., 2021, Kitani-Morii and Noto, 2020, Laurichesse and Soler, 2020, Adhikari et al., 2019, Brunet Avalos et al., 2019, Kim et al., 2019, Shokri et al., 2019, Croset et al., 2018, Gene Disruption Project members, 2018-, Hassan et al., 2018, Lee et al., 2018, Fochler et al., 2017, Carbone et al., 2016, Chen et al., 2016, Mezan et al., 2016, Nachman et al., 2015, Ugrankar et al., 2015, Butí et al., 2014, Costa et al., 2014, Gonzalez et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Krzemien et al., 2012, Lahaye et al., 2012, Abruzzi et al., 2011, Jungreis et al., 2011, Liu and Geisbrecht, 2011, Dilks and DiNardo, 2010, Klein et al., 2010, Swaminathan et al., 2010, Guerin and Kramer, 2009, Wayburn and Volk, 2009, Christensen et al., 2008.4.15, Cook et al., 2008.7.11, Dilks and DiNardo, 2008, Meyer et al., 2008, Usui et al., 2008, Wang et al., 2008, Chanana et al., 2007, Zeitlinger et al., 2007, Marcellini and Simpson, 2006, Sandmann et al., 2006, Simpson et al., 2006, Stroschein-Stevenson et al., 2006, Staudt et al., 2005, Takahashi and Ting, 2004, Nabel-Rosen et al., 2002, Pickeral et al., 2000, Whitlock and Bourguet, 2000)

stripe

(Ramanujam et al., 2021, Swaminathan et al., 2010, Staudt et al., 2005)

Name Synonyms

STRIPE

(Lahaye et al., 2012)

Stripe

(Dubey et al., 2020, Laddada et al., 2019, Boukhatmi et al., 2012, Klein et al., 2010, Bahri et al., 2009, Dilks and DiNardo, 2008, O'Farrell and Kylsten, 2008, Subramanian et al., 2007, Volohonsky et al., 2007, Kaplan et al., 2005, Bassett et al., 1997)

StripeB

(Enriquez et al., 2012)

Striped

(Jones, 2001)

Secondary FlyBase IDs

FBgn0010828
FBgn0026215

Datasets (6)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (6)

Result

Result Type

Title

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (261)