Gene model reviewed during 5.45
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
Heterodimer of scarlet with white.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\st using the Feature Mapper tool.
st transcripts are expressed at low levels throughout development with a peak of expression in early to mid-pupal stages. The st transcript level is not altered substantially in a w1 mutant backgound.
A transcript that is slightly smaller and less abundant than wild type is seen in st1 mutant pupae.
GBrowse - Visual display of RNA-Seq signalsView Dmel\st in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
st protein is located in the membranes of pigment granules within pigment cells and retinula cells of the eye. No evidence of its presence in the plasma membrane has been seen.
Eyes bright vermilion, darkening with age. Ocelli colorless, even in old fly; a reliable trait for classifying st se. Eyes of bw; st white. Eye color autonomous in larval optic discs transplanted into wild-type hosts. Larval Malpighian tubes pale yellow. Uptake of kynurenine by Malpighian tubules and eye discs severely deficient. 3-hydroxykynurenine accumulates only in pupae; virtually undetectable in larvae and adults. Activity of phenoxazinone synthetase, which is found in pigment granules and which catalyzes the bimolecular condensation of 3-hydroxykynurenine in the production of brown eye pigment, xanthommatin, markedly reduced in st.
st is required for the synthesis of ommochrome in any tissue and is involved in the transport of pigmentation precursors.
Lesions in st reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules.
Mutant alleles are useful as markers in clonal analysis.
Pteridines (neodrosopterin, drosopterin, isodrosopterin, aurodrosopterin, 6-acetyl-dihydrohomopterin, sepiapterin, dihydrobiopterin, biopterin, pterin and isoxanthopterin) have been quantified in single and double mutants.
Mutant individuals display bright red eyes.