TmII, tropomyosin, tropomyosin II, cTm, Tm
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Gene model reviewed during 6.32
1.253 (longest cDNA)
518, 504, 285, 252 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tm1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tm1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Tm1 CG4898
Relationship between "l(3)88EFi" and "Tm1" is unclear; a temperature-sensitive "l(3)88EFi" allele partially complements Tm102299 at 29oC.
Source for merge of Tm1 BcDNA:SD21996 was a shared cDNA ( date:030728 ).
Source for merge of Tm1 BcDNA:LD37158 was a shared cDNA ( date:020730 ).
Source for merge of Tm1 BcDNA:GH09289 was a shared cDNA ( date:030728 ).
The 'heavy tropomyosins', TmH-33 and TmH-34, are encoded by the Tm1 gene, using exons 16 and 15, respectively. They are specifically expressed in the indirect flight muscles.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Area matching Drosophila EST AI109898.
GstS1 interacts with the TnH-34 isoform of troponin-H in asynchronous indirect flight muscle.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Tm1 is required for specific cell movements during head morphogenesis and for accumulating high levels of osk mRNA at the posterior pole necessary for germ cell formation but not for abdominal development.
Tm1 cis-acting sequences contain a 90bp muscle activator site (MA), the region is sufficient to direct low level transcriptional regulation of an Hsp70/Ecol\lacZ reporter gene in all somatic and visceral muscles of the embryo and adult.
Tm1 mRNA synthesis and accumulation in the developing ovary and embryo has been studied. lac reporter gene constructs demonstrate 1.2kb of 5' sequence upstream of the Tm1 transcription start site is required to drive expression of both the maternal and zygotic transcripts in the nurse cells and embryo but not in the follicle cells of the ovariole.
The distribution of muscle enhancer elements and their control is similar to those regulating the expression of Tm1.
Tm1 transcription is controlled by multiple muscle type-specific cis-acting control elements and upstream and downstream promoter control elements.
Three variants of Tm1 have been determined, this variation does not affect flight ability.
Three variants of Tm1 have been determined by their mobility on 1-D and 2-D SDS-PAGE.
Structural gene for tropomyosin, a 34,000-dalton protein. At least five tropomyosin isoforms are encoded by Tm1, some in embryos (during myogenesis) and myogenic cell culture and others in the myofibrils of adult indirect flight muscles and leg muscles.
Tm1, muscle promoter of Tm2, Act57B and Mlc2 were not transcribed by embryonic extracts. The contractile protein genes may possess a common feature related to in vitro transcription that prevents their transcription.
Defined during molecular analysis of the 88F region.