Ndr serine/threonine kinase - required for the normal morphogenesis of epidermal hairs, bristles, laterals, and dendrites - regulates synapse development by regulating the levels of Wiskott-Aldrich Syndrome protein
Gene model reviewed during 5.43
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
None of the polypeptides share 100% sequence identity.
455 (aa); 52 (kD predicted)
Interacts with, and is activated by, Mob1.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\trc using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\trc in GBrowse 2
Mitotic location: 36.
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutations in trc result in the splitting or branching of cuticular structures produced by cytoskeletal-mediated outgrowths of epidermal cells (the adult epidermal hairs, the shafts of adult sense organs, the lateral extensions of the arista and the larval denticles).
Mutants do not exhibit defects in the denticle belt of hairs of the larvae.
cDNA clone encoding the homologue of human Ndr has been isolated and sequenced.
Mutant alleles are useful as markers in clonal analysis.