FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Treh
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General Information
Symbol
Dmel\Treh
Species
D. melanogaster
Name
Trehalase
Annotation Symbol
CG9364
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003748
Gene Model Status
Current
Stock Availability
18 publicly available
Enzyme Name (EC)
alpha,alpha-trehalase (3.2.1.28)
Gene Summary
Trehalase (Treh) encodes an enzyme that hydrolyzes the the disaccharide trehalose to two molecules of glucose in either the cytoplasm or the extracellular space. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

TRE

Key Links
Genomic Location
Cytogenetic map
57B16-57B19
Sequence location
Recombination map
2-92
RefSeq locus
NT_033778 REGION:21074018..21088945
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables alpha,alpha-trehalase activity
inferred from mutant phenotype
(Yamada et al., 2019, Oliver et al., 1978)
inferred from direct assay
(Yoshida et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables alpha,alpha-trehalase activity
inferred from electronic annotation with InterPro:IPR001661, InterPro:IPR018232
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN004635776
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in trehalose catabolic process
inferred from mutant phenotype
(Nishimura, 2020, Miyamoto and Amrein, 2019, Yamada et al., 2019, Yoshida et al., 2016, Eanes et al., 2006, Oliver et al., 1978)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in carbohydrate metabolic process
inferred from electronic annotation with InterPro:IPR008928, InterPro:IPR012341
(InterPro Project Members, 2004-)
involved_in trehalose catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN004635776
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:O43280
(Gene Ontology Curators, 2002-)
involved_in trehalose metabolic process
inferred from electronic annotation with InterPro:IPR001661, InterPro:IPR018232
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from direct assay
(Yamada et al., 2019)
located_in extracellular space
inferred from direct assay
(Yamada et al., 2019)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the glycosyl hydrolase 37 family. (Q9W2M2)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
alpha,alpha-trehalase activity
alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose (3.2.1.28)
RHEA 32675:
Summaries
Gene Snapshot
Trehalase (Treh) encodes an enzyme that hydrolyzes the the disaccharide trehalose to two molecules of glucose in either the cytoplasm or the extracellular space. [Date last reviewed: 2018-09-20]
Pathway (FlyBase)
TREHALOSE CATABOLISM -
In trehalose catabolism, trehalase Treh converts trehalose, a non-reducing disaccharide in the hemolymph, into 2 molecules of glucose. Trehalose can be hydrolyzed directly in the hemolymph by the Treh secreted isoform and the glucose produced can then be imported into cells. Alternatively, trehalose can be imported into the cell via the Tret1 transporter where it is cleaved by the Treh cytosolic isoform. (Adapted from FBrf0245354 and PMID:25429048.)
Gene Group (FlyBase)
UNCLASSIFIED O-GLYCOSYL HYDROLASES -
This group comprises O-glycosyl hydrolases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Enzyme that cleaves trehalose to produce 2 glucose molecules that can be used by the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it (PubMed:26235423).
(UniProt, Q9W2M2)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Treh: Trehalase
Structural gene for trehalase [TRE (EC 3.2.1.28)], a hydrolase that splits the sugar trehalose into two glucose molecules. Polyacrylamide gel electrophoresis and isoelectric focusing indicates the presence of one molecular form of the enzyme in flight muscles, hemolymph, and abdomens of adult flies. No mutant alleles obtained.
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Treh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W2M2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Treh-RA
FBtr0071537
NM_166421
2758
560
Treh-RB
FBtr0071538
NM_166425
2662
515
Treh-RC
FBtr0071539
NM_166423
2928
596
Treh-RD
FBtr0071536
NM_080082
2992
560
Treh-RE
FBtr0071535
NM_166422
3354
560
Treh-RF
FBtr0071540
NM_166424
2822
596
Treh-RG
FBtr0332423
NM_001274186
2991
560
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Treh-PA
FBpp0071466
63.6
560
4.83
A4UZR3
NP_726023
AAM68192
Treh-PB
FBpp0071467
58.7
515
4.68
NP_726027
AAF46669
Treh-PC
FBpp0071468
67.7
596
4.61
Q9W2M2
NP_726025
AAF46668
Treh-PD
FBpp0071465
63.6
560
4.83
A4UZR3
NP_524821
AAF46667
Treh-PE
FBpp0071464
63.6
560
4.83
A4UZR3
NP_726024
AAM68193
Treh-PF
FBpp0071469
67.7
596
4.61
Q9W2M2
NP_726026
AAM68194
Treh-PG
FBpp0304696
63.6
560
4.83
A4UZR3
NP_001261115
AGB93647
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

560 aa isoforms: Treh-PA, Treh-PD, Treh-PE, Treh-PG
596 aa isoforms: Treh-PC, Treh-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Treh using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.71

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in cytosol
inferred from direct assay
(Yamada et al., 2019)
located_in extracellular space
inferred from direct assay
(Yamada et al., 2019)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Treh in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Treh
Transgenic constructs containing regulatory region of Treh
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4da.PU
lethal, with Scer\GAL4repo.PU
lethal - all die before end of P-stage
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during first instar larval stage
lethal - all die during P-stage
lethal - all die during P-stage (with Df(2R)Exel6072)
lethal - all die during P-stage | recessive
partially lethal - majority die
partially lethal - majority die (with Df(2R)Exel6072)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4nSyb.PS
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2R)Exel6072)
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal developmental rate
abnormal locomotor behavior | adult stage, with Scer\GAL4Mef2.PR
abnormal neuroanatomy | adult stage, with Scer\GAL4repo.PU
abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4c768
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4C855a
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4NP3605
abnormal neuroanatomy | third instar larval stage (with Treh18)
abnormal neuroanatomy | third instar larval stage (with Treh41)
abnormal planar polarity, with Scer\GAL4pnr-MD237
abnormal starvation stress response | larval stage
abnormal stress response | larval stage
abnormal stress response | larval stage | recessive
decreased size | adult stage, with Scer\GAL4C-765
increased cell death | adult stage, with Scer\GAL4repo.PU
short lived, with Scer\GAL4repo.PU
some die during P-stage
some die during pupal stage
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during third instar larval stage
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
embryonic/larval hemolymph | larval stage
lamina | third instar larval stage, with Scer\GAL4c768
lamina | third instar larval stage, with Scer\GAL4C855a
lamina | third instar larval stage, with Scer\GAL4NP3605
larval outer optic anlage | third instar larval stage
larval outer optic anlage | third instar larval stage, with Scer\GAL4c768
larval outer optic anlage | third instar larval stage, with Scer\GAL4C855a
medulla | third instar larval stage, with Scer\GAL4C855a
medulla | third instar larval stage, with Scer\GAL4NP3605
mesonotum, with Scer\GAL4pnr-MD237
pupa
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4C-765
wing blade, with Scer\GAL4C-765
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\TREH
14 of 14
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Treh
13 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Treh
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\treh
11 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\treh
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\tre-1
14 of 14
Yes
Yes
Cele\tre-3
12 of 14
No
Yes
Cele\tre-5
11 of 14
No
Yes
Cele\tre-2
10 of 14
No
Yes
Cele\tre-4
8 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP012053
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\TRE1
13 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\NTH1
9 of 13
Yes
Yes
Scer\NTH2
9 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ntp1
8 of 12
Yes
Yes
Escherichia coli (enterobacterium) (3)
Ecol\treA
10 of 11
Yes
Yes
Ecol\treF
10 of 11
Yes
Yes
Ecol\ygjK
1 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Treh. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Trehl
11 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TREH; trehalase
    14 of 14
    275360
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Treh - Ance-4
      affinity chromatography technology, Identification by mass spectrometry, pull down, anti tag western blot
      (Yamada et al., 2020)
      Treh - Arc1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Art8
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG11777
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG13893
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG14450
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG14543
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG1532
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG18787
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG18789
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG3544
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - CG7049
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Ccs
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Got1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - HIP-R
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Hpf1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - ImpL2
      pull down, anti tag western blot, anti tag coimmunoprecipitation, affinity chromatography technology, Identification by mass spectrometry
      (Yamada et al., 2020)
      Treh - Irc
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Nagk
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Patsas
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Rae1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - RpS21
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Sod1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Trx2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - Yod1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - grsm
      experimental knowledge based
      (Guruharsha et al., 2011)
      Treh - simba2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Summary of Genetic Interactions
      Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      TREHALOSE CATABOLISM
      External Links
      FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
      KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-92
      Cytogenetic map
      57B16-57B19
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      57B16-57B19
      Limits computationally determined from genome sequence between P{EP}grauEP688&P{PZ}shg10469 and P{PZ}king-tubby02821&P{lacW}Xbp1k13803
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      57B-57C
      (determined by in situ hybridisation)
      (Louis et al., 1997, EDGP Project Members, 1994-)
      Experimentally Determined Recombination Data
      Location

      2-92

      (FlyBase, 2016)

      2-99.7

      (Comeron et al., 2012)

      2-92.0

      (Clark et al., 1995)

      1-

      (Choudhary et al., 1992)

      2-92.9 +/- 1.6

      (Burton and la Spada, 1986)
      Left of (cM)
      (Burton and la Spada, 1986)
      Right of (cM)
      (Burton and la Spada, 1986)
      Notes

      There is 16% recombination between Treh and bw.

      (Burton and la Spada, 1986)
      Stocks and Reagents
      Stocks (18)
      Genomic Clones (20)
      cDNA Clones (281)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Nishimura, 2020)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Treh plays a role in neuroepithelial stem cell maintenance and differentiation during optic lobe development in the larva.

          (Chen et al., 2014)

          The effects of a high sucrose diet on live weight, total protein, stored lipid and glycogen and crude activities of 12 enzymes involved in energy metabolism are quantified. The activities of many enzymes are reduced by the sucrose treatment.

          (Wang and Clark, 1995)

          Mobility variants at Treh are due to allozyme polymorphism.

          (Burton and la Spada, 1986)

          This gene was first recognised by a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.

          Structural gene for trehalase (TRE), a hydrolase that splits the sugar trehalose into two glucose molecules. Polyacrylamide gel electrophoresis and isoelectric focusing indicates the presence of one molecular form of the enzyme in flight muscles, hemolymph and abdomens of adult flies. No mutant alleles obtained.

          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Treh CG9364

          (Misra, 2000.8.9)
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (13)
          Reported As
          Symbol Synonym
          87D3T
          (Louis et al., 1997)
          CG9364
          (National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Yano et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Mack et al., 2006)
          DmTre
          (Shukla et al., 2016)
          ESTS:87D3T
          TRE
          (Montooth et al., 2003, Clark and Fucito, 1998, Clark and Wang, 1997, Clark et al., 1995, Wang and Clark, 1995, Clark, 1994, Clark, 1990, Clark et al., 1990)
          TREH
          (Choudhary et al., 1992)
          Tre
          (Clark and Wang, 1994)
          Treh
          (Zaru and Marygold, 2025, Bamgbose and Tulin, 2024, Chang et al., 2024, Connacher et al., 2024, Kazek et al., 2024, Dolezal, 2023, Fanara et al., 2023, Gáliková and Klepsatel, 2023, Rabah et al., 2023, Xu et al., 2023, Eickelberg et al., 2022, Hultmark and Andó, 2022, Majane et al., 2022, Oliveira et al., 2021, Ahmed and Vogel, 2020, Cho et al., 2020, Hudry et al., 2019, Karpova et al., 2019, Yamada et al., 2019, Clemson et al., 2018, Cogni et al., 2017, Mattila and Hietakangas, 2017, Mohr et al., 2017, Transgenic RNAi Project members, 2017-, Yasugi et al., 2017, Ng et al., 2016, Yoshida et al., 2016, Cogni et al., 2015, Gene Disruption Project members, 2015-, Matsuda et al., 2015, Volkenhoff et al., 2015, Chen et al., 2014, Fedotov et al., 2014, Lavington et al., 2014, Luck et al., 2014, Wang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kong et al., 2010, Wallace et al., 2010, Kent et al., 2009, Liu and Lehmann, 2008, Flowers et al., 2007, Laayouni et al., 2007, Betz and Darnell, 2006, Choksi et al., 2006, Dierick and Greenspan, 2006, Eanes et al., 2006)
          anon-EST:Posey159
          anon-sts38
          treh
          (Karpova et al., 2023)
          Name Synonyms
          Trehalase
          (Garlovsky et al., 2022, Kierdorf et al., 2020, Wang et al., 2013, Zhou et al., 2013, Yano et al., 2012, Cammarato et al., 2011)
          trehalase
          (Shukla et al., 2016, Musselman et al., 2011, Kent et al., 2009, Laayouni et al., 2007, Eanes et al., 2006, Montooth et al., 2003)
          Secondary FlyBase IDs
          • FBgn0014436
          • FBgn0025313
          • FBgn0034584
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 79 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (131)