Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
4.7 (northern blot)
1191 (aa); 123 (kD predicted)
Interacts with pnr, although weak this interaction is essential. Interacts with the isoform SrpNC of srp. Interacts with CtBP corepressor.
The CCHC FOG-type zinc fingers 1, 4 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ush using the Feature Mapper tool.
ush transcript is detected in early embryos, in third instar larvae, pupae, and at low levels in adults. In situ hybridization to late third instar larval imaginal discs show ush expression to be restricted to specific domains. These domains include the future dorsal-most region of the thorax, part of the hinge region, and the posterior pleura.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ush in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: ush CG2762
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.
ush has a critical role in several diverse processes of mesoderm differentiation and heart formation.
A member of the ush-group of genes which are required for maintenance of the amnioserosa once it has differentiated.
Mutants affect amnioserosa differentiation as well as germ band retraction.
Zygotically active locus involved in the terminal developmental program in the embryo.