5HT1A, 5HT-dro2A, 5-HT1A, 5-HT1ADro, d5-HT1A
Gene model reviewed during 5.46
Gene model reviewed during 5.50
Stop-codon suppression (UAG) postulated; FBrf0234051.
Gene model reviewed during 6.25
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\5-HT1A using the Feature Mapper tool.
5-HT1B transcripts are detected throughout development with a peak in 16-24hr embryos. They are found in adult heads but not bodies. In embryos, expression starts in stage 16 and is restricted to the CNS. In each abdominal segment, 5-HT1B transcripts are expressed in a group of 6-8 cells located ventrally on the midline that are thought to be the VUM neurons. In thoracic segments, they are also expressed in lateral cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\5-HT1A in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: 5-HT1A CG16720
Flies with reduced 5-HT1A in insulin-producing cells are less resistant to starvation and heat knockdown, and display delayed recovery from cold coma.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
5-HT1A receptor inhibits adenylate cyclase and activates phospholipase C. Expression starts in late embryos predominantly in midline motor neurones, suggesting a role in motor control. 5-HT1A and 5-HT1B have a common chromosomal location and high sequence homology suggesting they are the result of a recent duplication event.
One of several known Drosophila serotonin receptor encoding genes. Presumed to be a recent duplication of 5-HT1B gene.