FlyBase Gene Report: Dmel\Csp

General Information

Symbol

Dmel\Csp

Species

D. melanogaster

Name

Cysteine string protein

Annotation Symbol

CG6395

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004179

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

cystein string protein, l(3)03988, Dcsp, ab49

Key Links

Genomic Location

Cytogenetic map

79D3-79D3

Sequence location

3L:22,267,382..22,273,745 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:22267382..22273745

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in exocytosis

inferred from mutant phenotype

(Dawson-Scully et al., 2000)

involved_in neuron cellular homeostasis

inferred from genetic interaction with FLYBASE:GluRIIC; FB:FBgn0046113

(Brusich et al., 2015)

involved_in regulation of neuromuscular synaptic transmission

inferred from genetic interaction with FLYBASE:GluRIIC; FB:FBgn0046113

(Brusich et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in protein folding

non-traceable author statement

(Littleton et al., 1999)

involved_in regulation of neuromuscular synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN002890638

(GO Reference Genome Project, 2011-)

involved_in synaptic vesicle exocytosis

inferred from sequence or structural similarity

(Littleton, 2000)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in synaptic vesicle

inferred from direct assay

(Jiao et al., 2010)

located_in terminal bouton

inferred from direct assay

(Loveall and Deitcher, 2010)

located_in type Ib terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

located_in type Is terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in plasma membrane

inferred from sequence or structural similarity

(Zinsmaier et al., 1990)

is_active_in type Is terminal bouton

inferred from biological aspect of ancestor with PANTHER:PTN002890638

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES -: The Heat Shock Protein 40 (Hsp40) family of co-chaperones are essential factors in the Hsp70 chaperone cycle. The Hsp40 family is diverse in size and structure, but a number of them are about 40kDa and have been identified as products of heat shock genes. Their defining feature is the DnaJ or J-domain corresponding to the N-terminal 70 amino acids of the Escherichia coli co-chaperone DnaJ. (Adapted from FBrf0173155).

Protein Function (UniProtKB)

May have an important role in presynaptic function.

(UniProt, Q03751)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Csp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q03751)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Csp-RA

FBtr0078493

NM_079489

2832

223

Csp-RB

FBtr0078494

NM_168949

1842

249

Csp-RC

FBtr0078495

NM_168950

2226

228

Csp-RD

FBtr0334746

NM_001275277

1498

244

Csp-RE

FBtr0334747

NM_001275278

2895

244

Csp-RF

FBtr0344983

NM_001300215

2028

249

Additional Transcript Data and Comments

Reported size (kB)

2.9, 2.3 (northern blot)

(Zinsmaier et al., 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Csp-PA

FBpp0078145

23.8

223

5.03

NP_524213

AAF51817

Csp-PB

FBpp0078146

26.9

249

5.32

FBpp0078147

24.6

228

5.04

FBpp0306787

26.2

244

5.30

FBpp0306788

26.2

244

5.30

FBpp0311238

26.9

249

5.32

D0IQJ8

NP_001287144

AHN58169

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

249 aa isoforms: Csp-PB, Csp-PF

244 aa isoforms: Csp-PD, Csp-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

249, 223 (aa); 34, 32 (kD observed); 27, 24 (kD predicted)

(Zinsmaier et al., 1990)

Comments

External Data

Post Translational Modification

Fatty acylated. Heavily palmitoylated in the cysteine string motif.

(UniProt, Q03751)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Csp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Csp_1
Csp_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.01

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

(Pek et al., 2015)

(Pek et al., 2015)

(Zinsmaier et al., 1990)

organism

Comment: body without gonads

(Pek et al., 2015)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Zinsmaier et al., 1990)

retina

(Zinsmaier et al., 1990)

Additional Descriptive Data

Csp transcripts are detected in adult head RNA on northern blots.

(Zinsmaier et al., 1990)

Csp transcripts are detected in the retina and in the entire brain cellular rind.

(Zinsmaier et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

neuromuscular junction

(Zinsmaier et al., 1994)

third instar larval stage

embryonic/larval neuromuscular junction

Comment: presynaptic marker

(Zelhof et al., 2001)

embryonic/larval neuromuscular junction

• terminal bouton

(Bronk et al., 2001)

larval central nervous system

(Mohtashami et al., 2001)

NMJ bouton of muscle cell of A1-7 ventral longitudinal muscle 3

(Singh et al., 2010)

NMJ bouton of muscle cell of A1-7 ventral longitudinal muscle 4

(Singh et al., 2010)

neuromuscular junction of muscle cell of A1-7 lateral longitudinal muscle 1

• synapse

(Li et al., 2016)

embryonic/larval neuromuscular junction

• synaptic vesicle

Comment: observed at A1-7 ventral longitudinal muscle 3 and 4

(Fuentes-Medel et al., 2009)

adult stage

photoreceptor neuron

(Zinsmaier et al., 1994)

neuron

• synaptic vesicle

(Zinsmaier et al., 1994)

bouton

(Zinsmaier et al., 1994)

lobula plate

(Zinsmaier et al., 1994)

neuromuscular junction of adult thorax

(Zinsmaier et al., 1994)

photoreceptor neuron

• cytoplasm of terminal bouton

(Hiesinger et al., 2001)

photoreceptor cell R1 | restricted

(Hamanaka and Meinertzhagen, 2010)

photoreceptor cell R2 | restricted

(Hamanaka and Meinertzhagen, 2010)

photoreceptor cell R3 | restricted

(Hamanaka and Meinertzhagen, 2010)

photoreceptor cell R4 | restricted

(Hamanaka and Meinertzhagen, 2010)

photoreceptor cell R5 | restricted

(Hamanaka and Meinertzhagen, 2010)

photoreceptor cell R6 | restricted

(Hamanaka and Meinertzhagen, 2010)

medulla

(Zinsmaier et al., 1994)

medulla | restricted

(Hamanaka and Meinertzhagen, 2010)

ventral cervical muscle cell

• type I terminal bouton

(Rivlin et al., 2004)

muscle cell of prothoracic sternal anterior rotator muscle 31

• type I terminal bouton

(Rivlin et al., 2004)

muscle cell of prothoracic sternal adductor muscle 33

• type I terminal bouton

(Rivlin et al., 2004)

motor neuron

• type I terminal bouton

(Rivlin et al., 2004)

lamina | restricted

(Hamanaka and Meinertzhagen, 2010)

lamina

(Chaturvedi et al., 2014, Zinsmaier et al., 1994)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Csp is expressed in central brain neuropils. It is broadly seen in the R1-R6 terminals, but appears especially to line the borders facing the cartridge interior. Using immunoelectron microscopy, Csp is detected in the photoreceptor cells close to the T-bar ribbon surrounded by synaptic vesicles.

(Hamanaka and Meinertzhagen, 2010)

In the adult prothorax and neck, Csp immunoreactivity is observed in the type I boutons of motor neurons innervating ventral cervical muscles, prothoracic sternal anterior rotator muscle 31, and prothoracic sternal adductor muscle 33. Csp immunoreactivity is not detected in Type II boutons.

(Rivlin et al., 2004)

Csp protein is enriched in the neuropil of the larval ventral ganglion, where synapses occur.

(Mohtashami et al., 2001)

Csp protein is detected presynaptically at larval and adult neuromuscular junctions. Synaptic boutons are strongly stained. In the CNS, Synapse rich regions of the neuropil are stained, but the surrounding cell bodies are not. One isoform is detected predominantly in photoreceptor terminals but not at motor nerve terminals. Csp protein is thought to be associated with synaptic vesicles.

(Zinsmaier et al., 1994)

Marker for

NMJ bouton

(Singh et al., 2010)

synaptic vesicle

(Fuentes-Medel et al., 2009, Zelhof et al., 2001)

Subcellular Localization

CV Term

Evidence

References

located_in synaptic vesicle

inferred from direct assay

(Jiao et al., 2010)

located_in terminal bouton

inferred from direct assay

(Loveall and Deitcher, 2010)

located_in type Ib terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

located_in type Is terminal bouton

inferred from direct assay

(Rohrbough et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Csp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Csp

View exonic expression by tissue for Dmel\Csp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004179

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40459/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004179

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004179

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004179

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6395

Flygut - An atlas of the Drosophila adult midgut

FBgn0004179

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 39 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 32 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Csp

Transgenic constructs containing regulatory region of Csp

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(3L)Csp-X3

(Eberle et al., 1998)

In(3)Csp^R2

(Eberle et al., 1998)

Gene not disrupted in

Df(3L)Pc-MK

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3L)TO1

(Ohyama and Schulze, 2013.7.28)

Df(3L)TO2

(Ohyama and Schulze, 2013.7.28)

Df(3L)TO3

(Ohyama and Schulze, 2013.7.28)

Df(3L)TO4

(Ohyama and Schulze, 2013.7.28)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Csp^CB02217

lethal | recessive

Csp⁰³⁹⁸⁸

lethal - all die before end of larval stage | heat sensitive, with Scer\GAL4^elav-C155

lethal - all die before end of larval stage | heat sensitive, with Scer\GAL4^hs.PB

lethal - all die during embryonic stage | heat sensitive, with Scer\GAL4^elav-C155

Csp^1.UAS

lethal - all die during embryonic stage | heat sensitive, with Scer\GAL4^hs.PB

Csp^1.UAS

partially lethal | heat sensitive

partially lethal | temperature conditional

Csp^R1

partially lethal - majority die

Csp⁰³⁹⁸⁸

partially lethal - majority die | recessive

partially lethal - majority die | recessive | heat sensitive

Csp^U1

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Csp^GD10571

viable, with Scer\GAL4^elav-C155

viable, with Scer\GAL4^Mef2.PR

Csp^GD10571

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

abnormal behavior, with Scer\GAL4^elav-C155

abnormal body size | adult stage, with Scer\GAL4^elav-C155

abnormal courtship behavior | male

Csp^X1

abnormal neuroanatomy

Csp^R1

abnormal neuroanatomy | conditional

Csp^DG29203

abnormal neuroanatomy | conditional (with Csp^DG29203)

Csp^X1

abnormal neuroanatomy | conditional (with Csp^X1)

Csp^DG29203

abnormal neurophysiology

abnormal neurophysiology, with Scer\GAL4^C57, Scer\GAL4^elav-C155, Scer\GAL4^sca.PC

Csp^GD10571

abnormal neurophysiology | dominant

Csp^EY22488

abnormal neurophysiology | heat sensitive

abnormal neurophysiology | larval stage | recessive

Csp^R1

abnormal neurophysiology | recessive

Csp^E16

abnormal neurophysiology | temperature conditional

Csp^R1

abnormal neurophysiology | third instar larval stage (with Csp^U1)

Csp^X1

abnormal neurophysiology | third instar larval stage (with Csp^X1)

Csp^U1

abnormal optomotor response | recessive

Csp^U1w

decreased rate of movement, with Scer\GAL4^elav-C155

flightless, with Scer\GAL4^Mef2.PR

Csp^GD10571

paralytic | adult stage | heat sensitive

Csp^U1

paralytic | conditional | recessive

Csp^U1

paralytic | heat sensitive

paralytic | recessive | heat sensitive

short lived, with Scer\GAL4^elav-C155

short lived (with Csp^U1)

Csp^U1w

short lived (with Csp^U1w)

Csp^U1

short lived | recessive

Csp^U1

some die during embryonic stage | heat sensitive, with Scer\GAL4^elav-C155

Csp^1.UAS

some die during embryonic stage | heat sensitive, with Scer\GAL4^hs.PB

Csp^1.UAS

some die during larval stage | heat sensitive, with Scer\GAL4^elav-C155

some die during larval stage | heat sensitive, with Scer\GAL4^hs.PB

uncoordinated | adult stage, with Scer\GAL4^elav-C155

uncoordinated | recessive

Csp^U1

visible, with Scer\GAL4^elav-C155

wild-type

Csp^+t12.3

Phenotype manifest in

Allele

axon | larval stage

embryonic/larval neuromuscular junction (with Csp^U1)

Csp^X1

embryonic/larval neuromuscular junction (with Csp^X1)

Csp^U1

eye, with Scer\GAL4^elav-C155

germline cell | male, with Scer\GAL4^ptc-559.1

Csp^EP659

interommatidial bristle, with Scer\GAL4^elav-C155

neuromuscular junction

neuromuscular junction | larval stage

Csp^R1

NMJ bouton

Csp^R1

olfactory receptor neuron | conditional

Csp^DG29203

olfactory receptor neuron | conditional (with Csp^DG29203)

Csp^X1

olfactory receptor neuron | conditional (with Csp^X1)

Csp^DG29203

ommatidium, with Scer\GAL4^elav-C155

wing, with Scer\GAL4^elav-C155

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (35)

Hsap\DNAJC5B

12 of 14

Yes

Hsap\DNAJC5

12 of 14

Yes

Hsap\DNAJC5G

7 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Dnajc5b

12 of 14

Yes

Rnor\Dnajc5

12 of 14

Yes

Rnor\Dnajc5g

7 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Dnajc5b

12 of 14

Yes

Mmus\Dnajc5

11 of 14

Yes

Mmus\Dnajc5g

7 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\dnajc5b

9 of 13

Yes

Xtro\dnajc5

5 of 13

Yes

Xtro\dnajc5g

4 of 13

Yes

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (39)

Drer\dnajc5aa

12 of 14

Yes

Drer\dnajc5ab

11 of 14

Yes

Drer\dnajc5b

11 of 14

Yes

Drer\dnajc5ga

10 of 14

Yes

Drer\dnajc5gb

8 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\dnj-14

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP007620

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (68)

Atha\J20

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G05230

1 of 13

Yes

Atha\AT2G05250

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G42750

1 of 13

Yes

Atha\AT3G04980

1 of 13

Yes

Atha\AT3G06340

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G19580

1 of 13

Yes

Atha\AT4G19590

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G23590

1 of 13

Atha\AT5G25530

1 of 13

Atha\AT5G27240

1 of 13

Yes

Atha\AT5G37380

1 of 13

Atha\AT5G37440

1 of 13

Yes

Atha\AT5G37750

1 of 13

Yes

Atha\AT5G37760

1 of 13

Yes

Atha\AT5G49060

1 of 13

Atha\AT5G49580

1 of 13

Atha\AT5G53150

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (12)

Scer\CWC23

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (14)

Spom\cwf23

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Csp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (34)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

jdp

1 of 13

mrj

1 of 13

P58IPK

1 of 13

Rme-8

1 of 13

Sec63

1 of 13

shv

1 of 13

wus

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

neuronal ceroid lipofuscinosis 4

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Csp^V117R.UAS

model of neuronal ceroid lipofuscinosis 4

CEA

(Imler et al., 2019)

Csp^I118Δ.UAS

model of neuronal ceroid lipofuscinosis 4

CEA

(Imler et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

DNAJC5; DnaJ heat shock protein family (Hsp40) member C5

model of neuronal ceroid lipofuscinosis 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

Csp^+t12.3

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^G298S.UAS

(Coyne et al., 2017)

modeled by Hsap\TARDBP^UAS.Tag:MYC

(Coyne et al., 2017)

Csp^EP3141

ameliorates severe acute respiratory syndrome

modeled by HCoV-SARS\3a^{UAS.CUHK-W1.EGFP}

(Wong et al., 2005)

Csp^EP659

ameliorates severe acute respiratory syndrome

modeled by HCoV-SARS\3a^{UAS.CUHK-W1.EGFP}

(Wong et al., 2005)

Csp^R1

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Yu et al., 2023)

Csp^H45Q.UAS

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^G298S.UAS

(Coyne et al., 2017)

modeled by Hsap\TARDBP^UAS.Tag:MYC

(Coyne et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DNAJC5B; DnaJ heat shock protein family (Hsp40) member C5 beta

12 of 14

613945

DNAJC5; DnaJ heat shock protein family (Hsp40) member C5

12 of 14

DNAJ/HSP40 HOMOLOG, SUBFAMILY C, MEMBER 5; DNAJC5

CEROID LIPOFUSCINOSIS, NEURONAL, 4 (KUFS TYPE); CLN4

neuronal ceroid lipofuscinosis 4

DNAJC5G; DnaJ heat shock protein family (Hsp40) member C5 gamma

7 of 14

613946

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Csp - TBPH

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Romano et al., 2014)

Csp - pum

electrophoretic mobility shift assay, autoradiography

(Chen et al., 2008)

protein-protein

Physical Interaction

Assay

References

Csp - Ptp99A

two hybrid

(Bugga et al., 2009)

Csp - lap

anti tag coimmunoprecipitation, western blot

(Vanlandingham et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Csp

enhanceable

Hsc70-4

(Bronk et al., 2001, Wenniger et al., 1998)

Csp

suppressible

Syx1A

(Nie et al., 1999)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cac|GluRIIA

enhanceable

Csp

(Brusich et al., 2015)

Delta

suppressible

Csp

(Shalaby et al., 2009)

Hsc70-4

enhanceable

Csp

(Bronk et al., 2001)

pbl

enhanceable

Csp

(Gregory et al., 2007)

pbl

suppressible

Csp

(Gregory et al., 2007)

Syx1A

suppressible

Csp

(Nie et al., 1999)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65696

DroID - A comprehensive database of gene and protein interactions.

FBgn0004179

MIST (genetic) - An integrated Molecular Interaction Database

40459

MIST (protein-protein) - An integrated Molecular Interaction Database

40459

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

79D3-79D3

Sequence location

3L:22,267,382..22,273,745 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

79D3-79D3

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

79E-79E

(Lloyd et al., 2000)

79E1-79E2

(Zinsmaier, 1998.4.1)

79E1-79E2

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

32035

Csp^X1/TM3, Sb¹

31290

y¹ v¹; P{TRiP.JF01235}attP2

31669

y¹ v¹; P{TRiP.JF01462}attP2

33645

y¹ v¹; P{TRiP.HMS00046}attP2

22563

y¹ w^67c23; P{EPgy2}Csp^EY22488

51998

w^*; Csp^R1/TM6C, Tb¹ Sb¹

92700

y¹ w^*; TI{CRIMIC.TG4.2}Csp^{CR70088-TG4.2}

92347

y¹ w¹¹¹⁸; PBac{CH322-06D09-N-EGFP-Csp.G418}VK00033

NIG-Fly

6395R-1

P{NIG.6395R}1

HMS00046

y¹ v¹; P{TRiP.HMS00046}attP2/TM3, Sb¹

VDRC

v103201

P{KK109431}VIE-260B

v34167

w¹¹¹⁸; P{GD10571}v34167/TM3

More stocks available...

Genomic Clones (7)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (169)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD06525

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004179

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004179

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Zinsmaier et al., 1994)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Candidate stable intronic sequence RNA (sisRNA) identified within CDS of this gene.

(Pek et al., 2015)

The J-domain of Csp is important for minimising asynchronous release shortly after the evoked EJP.

(Bronk et al., 2005)

The J-domain of Csp is important in maintaining normal Ca[2+] resting levels in synaptic terminals.

(Bronk et al., 2005)

Csp has multiple functions at synaptic terminals. Csp plays a direct role in exocytosis downstream from Ca²⁺ entry. Csp seems to increase the Ca²⁺ sensitivity of the exocytotic machinery.

(Dawson-Scully et al., 2000)

Mutations in Csp affect calcium secretion coupling of evoked exocytosis but not vesicle recycling.

(Ranjan et al., 1998)

Fluorescent Ca-sensitive dye, Ca Crimson, is used to monitor presynaptic Ca dynamics.

(Umbach et al., 1998)

An analysis of the excitatory postsynaptic currents from depolarized motor nerve terminals leads to the conclusion that Csp protein is involved in neurotransmitter release and helps to synchronise evoked neurotransmitter release at nerve terminals.

(Heckmann et al., 1997)

Biochemical characterisation of Csp suggests that fatty acyl groups do not form the main anchor of Csp in membranes as the complete removal of this modification does not dissociate Csp from the membrane.

(van de Goor and Kelly, 1996)

n-syb and Csp proteins are targetted to synaptic vesicles.

(van de Goor et al., 1995)

Neuromuscular transmission is impaired presynaptically in Csp mutant larvae. Csp mutations disrupt depolarisation-secretion coupling, depolarisation fails to trigger transmitter release. This disruption explains the cellular basis of the temperature sensitive paralysis of the mutant larvae.

(Umbach et al., 1994)

A RNA helicase, member of the DEAD box protein family, is the adjacent transcript unit to Csp that expresses two RNA transcripts.

(Zinsmaier et al., 1994)

Csp gene product is required for stabilizing the components of the neurotransmitter release machinery, lack of Csp gene product causes block of synaptic transmissions at high temperatures.

(Zinsmaier et al., 1994)

Csp expression pattern has been studied: MAB ab49 antibodies were used to screen cDNA expression libraries to identify clones coding for recognized protein fragments.

(Zinsmaier et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: Csp l(3)03988

(Spradling et al., 1999)

Source for merge of: Csp anon-WO02059370.50

(FlyBase, 1996-)

Additional comments

Source for merge of Csp anon-WO02059370.50 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Csp CG6395

(Beasley, 1999.11, Worley, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (27)

Reported As

Symbol Synonym

CG6395

(Pek et al., 2015, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Verstreken and Bellen, 2000.9.4, Whitfield, 2000.4.28)

CSP

(Peng and Wang, 2024, Bertin et al., 2023, Hendricks et al., 2022, Bridi et al., 2021, Deruelle et al., 2021, Tsai et al., 2019, Zhu et al., 2019, Jin et al., 2018, Luo et al., 2017, Zhang et al., 2017, Xu et al., 2016, Kim et al., 2015, Uytterhoeven et al., 2015, Chaturvedi et al., 2014, Liu et al., 2014, Mao et al., 2014, Mhatre et al., 2014, Podufall et al., 2014, Vanlandingham et al., 2014, Chang et al., 2013, Duncan et al., 2013, Estes et al., 2013, Nahm et al., 2013, Ohyama and Schulze, 2013.7.28, Weaver et al., 2013, Xiong et al., 2013, Beck et al., 2012, Dimitroff et al., 2012, Füger et al., 2012, Jin et al., 2012, Kim et al., 2012, Wishart et al., 2012, Brooks et al., 2011, Chan et al., 2011, Henthorn et al., 2011, Liu et al., 2011, Miśkiewicz et al., 2011, Moua et al., 2011, Paddock et al., 2011, Uytterhoeven et al., 2011, Wang et al., 2011, Yu et al., 2011, Chouhan et al., 2010, Fei et al., 2010, Hamanaka and Meinertzhagen, 2010, Hamanaka et al., 2010, Jiao et al., 2010, Lee et al., 2010, Lorenzo et al., 2010, Loveall and Deitcher, 2010, Mosca and Schwarz, 2010, Phillips et al., 2010, Rozas et al., 2010, Singh et al., 2010, Vijayakrishnan et al., 2010, Williamson et al., 2010, Edwards and Meinertzhagen, 2009, Fischer et al., 2009, Gilestro et al., 2009, Johnson et al., 2009, Kumar et al., 2009, Ren et al., 2009, Zhang et al., 2009, Barkus et al., 2008, Borycz et al., 2008, Caygill and Johnston, 2008, Liebl et al., 2008, Mast et al., 2008, Ratnaparkhi et al., 2008, Rezával et al., 2008, Toda et al., 2008, Bao et al., 2007, Besse et al., 2007, Rolls et al., 2007, Stowers and Isacoff, 2007, Wagner et al., 2007, Zeng et al., 2007, Zhang et al., 2007, Ataman, 2006, Baqri et al., 2006, Chu et al., 2006, Dudu et al., 2006, Huang et al., 2006, Rister and Heisenberg, 2006, Wagh et al., 2006, Ayyub et al., 2005, Bao et al., 2005, Bronk et al., 2005, Consoulas et al., 2005, Martin et al., 2005, Murthy et al., 2005, Wu et al., 2005, Koh et al., 2004, Rivlin et al., 2004, Aravamudan and Broadie, 2003, Fabian-Fine et al., 2003, Verstreken et al., 2003, Wucherpfennig et al., 2003, Chen et al., 2002, Guichet et al., 2002, Mathew et al., 2002, Verstreken et al., 2002, Bronk et al., 2001, Gunawardena and Goldstein, 2001, Lloyd et al., 2000, Matos et al., 2000, Beumer et al., 1999, Reist et al., 1998, Zinsmaier, 1998.4.1, Gonzalez-Gaitan and Jackle, 1997, Linial and Parnas, 1996, Bate and Broadie, 1995)

CSP32

(Iliopoulos et al., 1997)

Csp

(Collins et al., 2024, Deo et al., 2024, Kozlov et al., 2023, Praschberger et al., 2023, Yu et al., 2023, Perlegos et al., 2022, Matinyan et al., 2021, Yeates and Frank, 2021, Aboukilila et al., 2020, Gupta and Stocker, 2020, Strassburger et al., 2019, Gene Disruption Project members, 2018-, Machamer et al., 2018, Ugrankar et al., 2018, Lee et al., 2016, Li et al., 2016, Aradska et al., 2015, Brusich et al., 2015, Omelyanchuk et al., 2015, Parchure et al., 2015, Štětina et al., 2015, Sun et al., 2015, Ashwal-Fluss et al., 2014, Merlo et al., 2014, Beckett et al., 2013, Kim et al., 2013, Lee et al., 2013, Maldonado et al., 2013, Rohrbough et al., 2013, Bridon et al., 2012, Cook et al., 2012, Gistelinck et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Mozer and Sandstrom, 2012, Rossetto et al., 2011, Li et al., 2010, Ayroles et al., 2009, Fuentes-Medel et al., 2009, Johnson et al., 2009, Lin et al., 2009, Nieratschker et al., 2009, Venken et al., 2009, Yamamoto et al., 2009, Chen et al., 2008, Kerman et al., 2008, Yamamoto et al., 2008, Blard et al., 2007, Buszczak et al., 2007, Goold and Davis, 2007, Gregory et al., 2007, Koh et al., 2007, Dierick and Greenspan, 2006, Takaesu et al., 2006, Gleason, 2005, Wong et al., 2005, Arnold et al., 2004, Cherry and Perrimon, 2004)

Cys

(Gleason and Ritchie, 2004)

D-CSP

(Buchner and Gundersen, 1997)

D.M.CSP

(Becker et al., 2001)

DCSP-1

(Reichmuth et al., 1995)

DNAJC5

(Wishart et al., 2012)

DSP/DNAJC5

(Wishart et al., 2012)

Dcsp

(Pahud et al., 1998, van de Goor and Kelly, 1996, van de Goor et al., 1995, Ganetzky, 1994)

MAB ab49

(Reichmuth et al., 1995)

ab49

(Botella et al., 2003, Song et al., 2002)

anon-WO02059370.50

csp

(Gundersen, 2020, Imler et al., 2019, Scholz et al., 2019, Jia Ng et al., 2018, Stephano et al., 2018, Coyne et al., 2017, Pek et al., 2015, Romano et al., 2014, Sarthi and Elefant, 2011, Mudiganti et al., 2010, Bugga et al., 2009, Dickman and Davis, 2009, Besse et al., 2007, Ohyama et al., 2007, Scantlebury et al., 2007, Serpe and O'Connor, 2006, Bronk et al., 2005, Wellington and Zinsmaier, 2005, Botella et al., 2003, Estes et al., 2003, McCabe et al., 2003, Barclay et al., 2002, Hebbar and Fernandes, 2002, Bronk et al., 2001, Hiesinger et al., 2001, Mohtashami et al., 2001, Saitoe et al., 2001, Saitoe et al., 2001, Verstreken and Bellen, 2001, Bellen, 2000.12.25, Estes et al., 2000, Nie et al., 1999, Rohrbough et al., 1999, Wu et al., 1999, Eberle et al., 1998, Peixoto and Hall, 1998, Ranjan et al., 1998, Stimson et al., 1998, Wenniger et al., 1998, Heckmann et al., 1997, Umbach and Gundersen, 1997, Wu and Bellen, 1997, Estes et al., 1996, Littleton et al., 1995, Parfitt et al., 1995, Umbach et al., 1994, Zinsmaier et al., 1994, Eberle et al., 1993, Zinsmaier et al., 1993, Zinsmaier and Benzer, 1991)

csp29

(Zinsmaier, 1993.1.19)

csp32

(Zinsmaier, 1993.1.19)

dCSP-2

(Imler et al., 2019)

dCSPα

(Rigon et al., 2021)

dDNAJC5

(Lee et al., 2025)

l(3)03988

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

Name Synonyms

Cysteine String Protein

(Parchure et al., 2015, Dimitroff et al., 2012, Mozer and Sandstrom, 2012, Mosca and Schwarz, 2010, Johnson et al., 2009, Chu et al., 2006, Ayyub et al., 2005, Aravamudan and Broadie, 2003, Andrews et al., 2002)

Cysteine string protein

(Chaturvedi et al., 2014, Mhatre et al., 2014, Beckett et al., 2013, Sarthi and Elefant, 2011, Fei et al., 2010, Fuentes-Medel et al., 2009, Shalaby et al., 2009, Yamamoto et al., 2009, Yamamoto et al., 2008, Blard et al., 2007, Jordan et al., 2007, Koh et al., 2007, Gleason, 2005)

Cysteine string protein 3

(Khanna et al., 2010)

cystein string protein

(Cook et al., 2012, Gilestro et al., 2009, Kurshan et al., 2009, Rezával et al., 2008, Baqri et al., 2006)

cysteine string protein

(Tsai et al., 2019, Xu et al., 2016, Mhatre et al., 2014, Duncan et al., 2013, Estes et al., 2013, Forrest et al., 2013, Kim et al., 2013, Maldonado et al., 2013, Weaver et al., 2013, Beck et al., 2012, Bridon et al., 2012, Kim et al., 2012, Henthorn et al., 2011, de Haro et al., 2010, Hamanaka et al., 2010, Lorenzo et al., 2010, Loveall and Deitcher, 2010, Nahm et al., 2010, Phillips et al., 2010, Edwards and Meinertzhagen, 2009, Nieratschker et al., 2009, Ren et al., 2009, Zhang et al., 2009, Barkus et al., 2008, Borycz et al., 2008, Caygill and Johnston, 2008, Toda et al., 2008, Haghnia et al., 2007, Rolls et al., 2007, Scantlebury et al., 2007, Stowers and Isacoff, 2007, Acharya et al., 2006, Hebbar et al., 2006, Huang et al., 2006, Bronk et al., 2005, Martin et al., 2005, Arnold et al., 2004, Cherry and Perrimon, 2004, Chen et al., 2002, Verstreken and Bellen, 2002, Estes et al., 2000)

cysteine-string protein

(Lanson et al., 2011, Liu et al., 2011, Chouhan et al., 2010, Vijayakrishnan et al., 2010, Bao et al., 2007, Bao et al., 2005, Wu et al., 2005)

Secondary FlyBase IDs

FBgn0010827
FBgn0066009

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 76 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40459

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q03751

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q03751

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q03751

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004179

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40459/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004179

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004179

FlyMine - An integrated database for Drosophila genomics

FBgn0004179

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6395

MARRVEL_MODEL - MARRVEL (model organism gene)

40459

Linkouts

BioGRID - A database of protein and genetic interactions.

65696

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004179

DroID - A comprehensive database of gene and protein interactions.

FBgn0004179

DRSC - Results frm RNAi screens

FBgn0004179

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Csp_1
Csp_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004179

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004179

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6395

Flygut - An atlas of the Drosophila adult midgut

FBgn0004179

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004179

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015301

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

MIST (genetic) - An integrated Molecular Interaction Database

40459

MIST (protein-protein) - An integrated Molecular Interaction Database

40459

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (366)

The following external sites may use different assemblies or annotations than FlyBase.

-1.01

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