hrp36, P11, hnRNPA1, Hrb87Fa, Q16
Please see the JBrowse view of Dmel\Hrb87F for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
1.1 (longest cDNA)
2.2, 1.7 (northern blot)
2.3, 1.8 (compiled cDNA)
36 (kD observed)
326 (aa); 34 (kD observed); 34 (kD predicted)
386 (aa); 40 (kD predicted)
386 (aa); 38 (kD observed); 40 (kD predicted)
One of a couple of protein products.
hnRNP-specific mAbs were obtained and used to purify hnRNP complexes from S2 cells. hnRNP proteins were identified on the basis of nucleoplasmic localization, association with nascent transcripts, crosslinking to poly(A)-containing RNA in living cells, and amino acid sequence. Staining of polytene chromosomes reveals that Hrb87F protein is associated with actively transcribing loci.
Hrb87F protein has two amino-terminal RNP-CS RNA-binding domains and a carboxy-terminal glycine-rich auxiliary domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrb87F using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
2.3kb Hrb87F transcripts are expressed throughout development. Transcripts are abundant in ovaries and early embryos, decline in late embryos and early larvae, and then increase again from the second larval instar stage.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Hrb87F in JBrowse3-54
3-51.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal
Loss of Hrb87F slows development, with a significant reduction in adult life span, decreased female fecundity and high sensitivity to starvation and thermal stresses.
The distribution of the hnRNP protein Hrb87F on nascent transcripts from polytene chromosomes has been studied.
An Hrb87F cDNA clone has been isolated and sequenced.
Hrb87F has been cloned and sequenced.
412 element inserted in 3' UTR in some Canton S lines
Homology to the mammalian A and B hnRNP proteins based on amino acid sequence inferred from nucleotide sequence.
Source for merge of: Hrb87F CG12749
Source for merge of: Hrb87F Hrb85CD