FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ten-m
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General Information
Symbol
Dmel\Ten-m
Species
D. melanogaster
Name
Tenascin major
Annotation Symbol
CG5723
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004449
Gene Model Status
Current
Stock Availability
75 publicly available
Gene Summary
Tenascin major (Ten-m) encodes a type II dimeric transmembrane protein whose extracellular domain mediates interactions with itself and with its paralogous protein encoded by Ten-a. It also interacts intracellularly with cytoskeleton regulatory proteins. Ten-m product regulates synaptic partner matching and axon guidance in the embryonic nervous system, as well as synaptic organization in olfactory and neuromuscular systems. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
All Summaries
Also Known As

odz, Tenm, odd Oz, Teneurin, l(3)05309

Key Links
Genomic Location
Cytogenetic map
79D4-79E3
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:22293044..22407863
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (37 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables filamin binding
inferred from direct assay
(Zheng et al., 2011)
enables identical protein binding
inferred from direct assay
(Hong et al., 2012)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VYN8
(Hong et al., 2012, Mosca et al., 2012)
inferred from physical interaction with UniProtKB:Q9NGK5
(Mosca et al., 2012)
enables protein heterodimerization activity
inferred from direct assay
(Hong et al., 2012)
enables protein homodimerization activity
inferred from direct assay
(Hong et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables signaling receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN000880693
(GO Reference Genome Project, 2011-)
Biological Process (24 terms)
Terms Based on Experimental Evidence (22 terms)
CV Term
Evidence
References
involved_in chaeta development
inferred from mutant phenotype
(Kinel-Tahan et al., 2007)
involved_in compound eye corneal lens development
inferred from mutant phenotype
(Kinel-Tahan et al., 2007)
involved_in compound eye morphogenesis
inferred from mutant phenotype
(Kinel-Tahan et al., 2007)
involved_in compound eye photoreceptor development
inferred from mutant phenotype
(Kinel-Tahan et al., 2007)
involved_in cytoplasmic microtubule organization
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in maintenance of alignment of postsynaptic density and presynaptic active zone
inferred from mutant phenotype
(Mosca et al., 2012)
inferred from direct assay
(Mosca et al., 2012)
involved_in maintenance of presynaptic active zone structure
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Zheng et al., 2011)
involved_in neuromuscular synaptic transmission
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in positive regulation of heterotypic cell-cell adhesion
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in positive regulation of locomotion
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in postsynaptic membrane organization
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in postsynaptic spectrin-associated cytoskeleton organization
inferred from mutant phenotype
(Mosca et al., 2012)
inferred from direct assay
(Mosca et al., 2012)
involved_in presynaptic membrane organization
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in R7 cell development
inferred from mutant phenotype
(Kinel-Tahan et al., 2007)
involved_in regulation of homotypic cell-cell adhesion
inferred from mutant phenotype
(Mosca et al., 2012)
inferred from direct assay
(Hong et al., 2012)
involved_in regulation of terminal button organization
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in synapse organization
inferred from direct assay
(Hong et al., 2012)
involved_in synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in synaptic target attraction
inferred from mutant phenotype
(Hong et al., 2012)
involved_in synaptic target recognition
inferred from direct assay
(Hong et al., 2012)
inferred from mutant phenotype
(Mosca et al., 2012)
involved_in synaptic vesicle membrane organization
inferred from mutant phenotype
(Mosca et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000131429
(GO Reference Genome Project, 2011-)
involved_in synaptic membrane adhesion
inferred from biological aspect of ancestor with PANTHER:PTN000131429
(GO Reference Genome Project, 2011-)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in neuromuscular junction
inferred from direct assay
(Mosca et al., 2012)
located_in neuronal cell body
inferred from direct assay
(Hong et al., 2012)
located_in plasma membrane
inferred from direct assay
(Dgany and Wides, 2002)
inferred from high throughput direct assay
(Lye et al., 2014)
located_in postsynaptic membrane
inferred from direct assay
(Mosca et al., 2012)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in extracellular matrix
inferred from sequence or structural similarity
(Fessler et al., 1994)
is_active_in glutamatergic synapse
inferred from biological aspect of ancestor with PANTHER:PTN000131429
(GO Reference Genome Project, 2011-)
is_active_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000131429
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000880693
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the tenascin family. Teneurin subfamily. (O61307)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Tenascin major (Ten-m) encodes a type II dimeric transmembrane protein whose extracellular domain mediates interactions with itself and with its paralogous protein encoded by Ten-a. It also interacts intracellularly with cytoskeleton regulatory proteins. Ten-m product regulates synaptic partner matching and axon guidance in the embryonic nervous system, as well as synaptic organization in olfactory and neuromuscular systems. [Date last reviewed: 2018-09-06]
Protein Function (UniProtKB)
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre-synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also required for peripheral axon growth cone guidance and target recognition of motor neurons.
(UniProt, O61307)
Summary (Interactive Fly)

transmembrane protein that acts together with the filamin Cheerio to influence growth cone progression - acts in projection neurons autonomously to regulate acetylcholine receptor cluster number and transsynaptically to regulate olfactory receptor neuron active zone number

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Ten-m for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O61307)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ten-m-RB
FBtr0078509
NM_079491
11411
2731
Ten-m-RD
FBtr0306107
NM_001104191
12169
3297
Ten-m-RE
FBtr0330159
NM_001275282
12169
3349
Additional Transcript Data and Comments
Reported size (kB)

11.5, 10.5 (northern blot)

(Baumgartner et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ten-m-PB
FBpp0078161
304.1
2731
6.76
O61307
NP_524215
AAF51824
Ten-m-PD
FBpp0297244
366.1
3297
6.00
NP_001097661
ABW08579
Ten-m-PE
FBpp0303192
372.0
3349
5.77
M9PGF7
NP_001262211
AGB94904
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

2515 (aa); 900, 270 (kD observed); 281 (kD predicted)

(Baumgartner et al., 1994)

>2406 (aa); 70, 55 (kD observed); 300 (kD predicted)

(Levine et al., 1994)
Comments

By Western and immunoprecipitation analyses, the Ten-m protein appears to be a large 900-1000kD secreted proteoglycan. After digestion with chondroitinase ABC, a ~270 kD core is released, whose size agrees well with the predicted molecular weight of 281 kD. Ten-m, a putative secondary pair rule gene product, is an extracellular protein.

(Baumgartner et al., 1994)

The predicted 300 kD Ten-m protein might be post-translationally modified to give the 55 and 70 kD forms observed on Western blots. The EGF repeats of the Ten-m protein show 39% amino acid identity with the EGF repeats of mouse tenascin.

(Levine et al., 1994)

The predicted 300 kD Ten-m protein might be

post-translationally modified to give the 55 and 70 kD forms observed on

Western blots. The EGF repeats of the Ten-m protein show 39% amino acid

identity with the EGF repeats of mouse tenascin.

(Levine et al., 1994)
External Data
Subunit Structure (UniProtKB)

Homodimer. Heterodimer with Ten-a. Interacts with Ten-a; the interaction occurs at the neuromuscular junction. Interacts with alpha-Spec and cher.

(UniProt, O61307)
Post Translational Modification

Phosphorylated. Phosphorylation occurs at tyrosine residues.

Proteolytically cleaved.

(UniProt, O61307)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ten-m using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.92

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
(Baumgartner et al., 1994)
embryonic stage 6
organism | segmentally repeated
(Baumgartner et al., 1994)
embryonic stage 6 -- 9
organism | segmentally repeated

Comment: reference specifies 2.5-3.5 hr AEL

(Levine et al., 1994)
embryonic stage 8
anterior transverse furrow
(Zheng et al., 2011, Baumgartner et al., 1994)
posterior transverse furrow
(Zheng et al., 2011, Baumgartner et al., 1994)
cephalic furrow
(Zheng et al., 2011)
amnioproctodeal invagination
(Zheng et al., 2011)
embryonic stage 8 -- 9
posterior midgut primordium
(Baumgartner et al., 1994)
embryonic stage 9
mesoderm
(Baumgartner et al., 1994)
embryonic stage 10
procephalic neurogenic region
(Baumgartner et al., 1994)
embryonic stage 10 -- 12
organism | segmentally repeated

Comment: reference states 4.5-7.5 hr AEL

(Levine et al., 1994)
embryonic stage 11
stomodeum
(Baumgartner et al., 1994)
embryonic stage 11 -- 12
tracheal system
(Baumgartner et al., 1994)
mesoderm | segmentally repeated

Comment: reference states 5.5-7.5 hr AEL

(Levine et al., 1994)
embryonic stage 11 -- 15
epidermis | striped
(Zheng et al., 2011)
embryonic stage 12
neuron | restricted
(Baumgartner et al., 1994)
embryonic stage 12 -- 15
larval longitudinal connective
(Baumgartner et al., 1994)
larval ventral nerve cord
(Baumgartner et al., 1994)
larval posterior commissure
(Baumgartner et al., 1994)
larval anterior commissure
(Baumgartner et al., 1994)
embryonic stage 13
dorsal vessel wall cell

Comment: reference states 9.5 hr AEL

(Baumgartner et al., 1994, Levine et al., 1994)
neuron
• axon
(Baumgartner et al., 1994)
embryonic/larval lymph gland | presumptive
(Baumgartner et al., 1994)
presumptive embryonic/larval central nervous system | restricted

Comment: reference states 9.5 hr AEL

(Levine et al., 1994)
larval ventral nerve cord
(Zheng et al., 2011)
embryonic stage 15
visceral trunk mesoderm
(Baumgartner et al., 1994)
larval central nervous system

Comment: axons

(Zheng et al., 2011)
embryonic stage 16
muscle attachment site
(Baumgartner et al., 1994)
larval stage
neuron
• axon
(Baumgartner et al., 1994)
imaginal disc
(Baumgartner et al., 1994)
third instar larval stage
larval multidendritic class I neuron
(Hattori et al., 2013)
larval multidendritic class IV neuron | faint
(Hattori et al., 2013)
eye disc posterior to the morphogenetic furrow
(Kinel-Tahan et al., 2007)
eye photoreceptor precursor cell | subset
(Kinel-Tahan et al., 2007)
wandering third instar larval stage
eye disc morphogenetic furrow
(Levine et al., 1997)
eye disc posterior to the morphogenetic furrow
(Levine et al., 1997)
ommatidial precursor cluster | restricted

Comment: single cell, likely R7

(Levine et al., 1997)
photoreceptor cell R7
(Levine et al., 1997)
adepithelial cell of eye-antennal disc
(Levine et al., 1997)
antennal disc | restricted
(Levine et al., 1997)
maxillary palp | precursor
(Levine et al., 1997)
rostral membrane | precursor
(Levine et al., 1997)
segment of antenna | precursor
(Levine et al., 1997)
first segment of antenna | intense | precursor
(Levine et al., 1997)
adult head capsule | precursor
(Levine et al., 1997)
embryonic/larval optic stalk
(Levine et al., 1997)
clypeo-labral disc | uniform
(Levine et al., 1997)
labial disc | uniform
(Levine et al., 1997)
wing pouch | restricted
(Levine et al., 1997)
wing vein L3 | precursor
(Levine et al., 1997)
presumptive 1st axillary sclerite
(Levine et al., 1997)
presumptive 3rd axillary sclerite
(Levine et al., 1997)
presumptive 4th axillary sclerite
(Levine et al., 1997)
prealar apophysis | precursor
(Levine et al., 1997)
yellow club | precursor
(Levine et al., 1997)
pleural wing process | precursor
(Levine et al., 1997)
pleural wing sclerite | precursor
(Levine et al., 1997)
campaniform sensillum of proximal dorsal radius | precursor
(Levine et al., 1997)
presumptive tegula
(Levine et al., 1997)
presumptive axillary cord
(Levine et al., 1997)
proximal costal vein | precursor
(Levine et al., 1997)
presumptive scutum
(Levine et al., 1997)
presumptive prescutum
(Levine et al., 1997)
presumptive anterior notal wing process
(Levine et al., 1997)
presumptive posterior notal wing process
(Levine et al., 1997)
dorsal mesothoracic pleura primordium
(Levine et al., 1997)
alar lobe | precursor
(Levine et al., 1997)
wing hinge primordium
(Levine et al., 1997)
haltere disc | restricted
(Levine et al., 1997)
dorsal pedicellar campaniform sensillum | precursor
(Levine et al., 1997)
ventral pedicellar campaniform sensillum | precursor
(Levine et al., 1997)
chordotonal organ of scabellum | precursor
(Levine et al., 1997)
dorsal scabellar campaniform sensillum | precursor
(Levine et al., 1997)
ventral scabellar campaniform sensillum | precursor
(Levine et al., 1997)
leg disc | restricted
(Levine et al., 1997)
embryonic/larval optic lobe | restricted
(Levine et al., 1997)
larval ventral nerve cord | restricted
(Levine et al., 1997)
embryonic/larval neuromuscular junction
(Mosca et al., 2012)
embryonic/larval motor neuron
(Mosca et al., 2012)
prepupal stage P4(ii) -- pharate adult stage P8
antennal lobe

Comment: 12h-48h APF

(Hong et al., 2012)
pupal stage
eye
(Baumgartner et al., 1994)
pharate adult stage P8
antennal lobe | faint | ubiquitous

Comment: 48h APF

(Hong et al., 2012)
antennal lobe glomerulus VA1d | intense

Comment: 48h APF

(Hong et al., 2012)
antennal lobe glomerulus VA1v | intense

Comment: 48h APF

(Hong et al., 2012)
antennal lobe glomerulus DA3 | intense

Comment: 48h APF

(Hong et al., 2012)
adult stage
antennal lobe projection neuron | punctate
(Hong et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data

At the cellular blastoderm stage (2.5 hours), Ten-m protein is visible at the periphery of cells, suggesting a plasma-membrane associated or extracellular localization.

(Mosca et al., 2012, Levine et al., 1994)

At embryonic stage 8, Ten-m (as well as cher), is expressed in all furrows and in the posterior midgut. It is expressed in a repetitive pattern at stage 11. By stage 13, it is epressed in the ventral nerve cord. At stage 15, Ten-m is expressed in the axons of the CNS. It is expressed in bands of epidermal cells at segmental boundaries, where it colocalizes with cher.

(Zheng et al., 2011)

Ten-m is expressed posterior to the morphogenetic furrow in the third instar eye disc, and as point-like expression in more mature developing ommatidia. At higher resolutions, Ten-m can be seen in four staggered columns of preclusteres after the furrow, at the periphery of cells.

(Kinel-Tahan et al., 2007)

Ten-m protein is expressed in a complex pattern of the eye-antennal disc in the third instar larva. Protein is distributed in in a row of cells in the morphogenetic furrow, and in two rows posterior to the furrow; staining in these cells is uniform, and consistant with a cell surface distribution. No staining is observed for another 10 cell diameters, after which Ten-m expression is observed in a single cell, likely the R7 photoreceptor cell, of each maturing ommatidium. Expression is also observed in the optic stalk, and in two clusters of adepithelial cells, one in the eye disc and one in the antennal disc. Expression in the antennal disc is observed in the presumptive maxillary palpus, in the presumptive antennal segments, in the presumptive head capsule, and in the presumptive rostral membrane.

(Levine et al., 1997)

Ten-m protein is expressed in a complex pattern in the wing disc. In the wing pouch, it is expressed in two hook-shaped contiguous lines of expression in apposing patterns on either side of the dorsal/ventral boundary; a portion of each parallels about a quarter of the dorsal/ventral boundary at a distance of 3-4 cell lengths, then turns to follow the anterior/posterior boundary at about the location of the presumptive third longitudinal wing vein. Expression is also observed in the presumptive first, third, and fourth axillary sclerites, in the presumptive prealar apophysis, the presumptive pleural wing process, the presumptive yellow club, the presumptive pleural wing sclerite, and in the dorsal tissue giving rise to the proximal dorsal radius and the sensilla campaniformia that cover it. Expression is also observed in the presumptive proximal costal vein, in the presumptive prescutum and scutum, in the presumptive anterior and posterior notal wing processes, the presumptive tegula, the presumptive alula, the presumtive axillary cord, and in the regions of presumptive pleura adjacent to the wing.

(Levine et al., 1997)

Ten-m protein expression is strong in the regions of the haltere disc that give rise to the sensilla of the dorsal and ventral pedicel, and of dorsal and ventral scabellum. Ten-m protein is distributed in concentric rings in the leg discs, corresponding to the segments of the adult leg.

(Levine et al., 1997)

The Ten-m protein is present uniformly in the anterior-posterior axis, and in an anterior domain in stage 5 embryos, but by stage 6, a repetitive pattern comprising seven full stripes and two partial stripes are visible. By stage 8, Ten-m protein is present in the anterior and posterior transverse furrows, and in the posterior midgut primordia, with decreasing staining in the ectoderm. By stage 9, Ten-m protein is only visible in the mesoderm. At stage 10, the neuroblasts of the procephalic lobe stain for Ten-m protein, and from stage 12 to 15 Ten-m protein is visible in the axons of the ventral nerve cord. At stage 11, staining in the tracheal system becomes visible. At stages 12-13, staining is also seen in cardiac cells. At stage 16, muscle attachment sites show staining.

(Baumgartner et al., 1994)

The 7 stripe segmentally repeated pattern of Ten-m protein expression in 2.5 to 3.5 hour embryos is followed by a 14-stripe segmentally repeated pattern of expression at 4.5 to 7.5 hours. The most intense segmentally repeated staining is seen in the mesoderm. At 9.5 hours, Ten-m protein is found in cardiac mesoderm cells, which will become cardioblasts. Also at 9.5 hours, and continuing through embryogenesis, is central nervous system staining of longitudinal and commissural axon tract bundles.

(Levine et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in neuromuscular junction
inferred from direct assay
(Mosca et al., 2012)
located_in neuronal cell body
inferred from direct assay
(Hong et al., 2012)
located_in plasma membrane
inferred from direct assay
(Dgany and Wides, 2002)
inferred from high throughput direct assay
(Lye et al., 2014)
located_in postsynaptic membrane
inferred from direct assay
(Mosca et al., 2012)
Expression Deduced from Reporters
Reporter: P{GawB}Ten-mNP6658
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval multidendritic class I neuron
(Hattori et al., 2013)
larval multidendritic class IV neuron | faint
(Hattori et al., 2013)
embryonic/larval epidermis
(Hattori et al., 2013)
abdominal posterior ventral multidendritic neuron vdap
(Hattori et al., 2013)
larval dorsal multidendritic neuron ddaC
(Hattori et al., 2013)
larval dorsal multidendritic neuron ddaD
(Hattori et al., 2013)
larval dorsal multidendritic neuron ddaE
(Hattori et al., 2013)
wandering third instar larval stage
embryonic/larval neuromuscular junction
(Mosca et al., 2012)
embryonic/larval motor neuron
(Mosca et al., 2012)
larval ventral nerve cord
(Mosca et al., 2012)
larval DA3 motor neuron
(Mosca et al., 2012)
muscle cell
(Mosca et al., 2012)
muscle cell of dorsal oblique muscle 3 | intense
(Mosca et al., 2012)
A1-7 segment border muscle cell | intense
(Mosca et al., 2012)
adult stage
antennal lobe | faint | ubiquitous
(Hong et al., 2012)
antennal lobe glomerulus VA1d | intense
(Hong et al., 2012)
antennal lobe glomerulus VA1v | intense
(Hong et al., 2012)
antennal lobe glomerulus DA3 | intense
(Hong et al., 2012)
adult antennal lobe projection neuron VA1d adPN
(Hong et al., 2012)
adult antennal lobe projection neuron VA1v adPN
(Hong et al., 2012)
adult antennal lobe projection neuron DA3 adPN
(Hong et al., 2012)
adult olfactory receptor neuron Or23a
(Hong et al., 2012)
adult olfactory receptor neuron Or88a
(Hong et al., 2012)
adult olfactory receptor neuron Or47b
(Hong et al., 2012)
Reporter: P{PTT-GB}Ten-mCB04632
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
embryonic/larval epidermis | striped
(Zheng et al., 2011)
Reporter: PBac{681.P.FSVS-1}Ten-mCPTI001175
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted

Comment: not in mushroom body and ellipsoid body

(Knowles-Barley, 2011.8.24)
Reporter: PBac{681.P.FSVS-1}Ten-mCPTI001273
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
adult brain
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ten-m in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 59 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ten-m
Transgenic constructs containing regulatory region of Ten-m
Aberrations (Deficiencies and Duplications) ( 18 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3L)ED230)
lethal (with Df(3L)Exel6138)
lethal (with Df(3L)Ten-m-AL1)
lethal (with Df(3L)Ten-m-AL29)
lethal (with Ten-m628)
lethal (with Ten-m05309)
lethal (with Ten-mCB04632)
lethal (with Ten-mKG00101)
lethal (with Ten-mΔ510)
lethal (with Ten-mΔ525)
lethal | recessive
lethal - all die before end of P-stage
lethal - all die during embryonic stage
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3L)Exel6138)
viable (with Ten-m05309)
viable (with Ten-mKG00101)
viable (with Ten-mN1-R11)
viable (with Ten-mN1-R60)
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal body size | P-stage
abnormal locomotor behavior | adult stage (with Ten-m05309)
abnormal locomotor behavior | adult stage (with Ten-mNP6658)
abnormal locomotor behavior | larval stage (with Ten-m05309)
abnormal locomotor behavior | larval stage (with Ten-mNP6658)
abnormal neuroanatomy, with Scer\GAL4221
abnormal neuroanatomy, with Scer\GAL4arm.PU
abnormal neuroanatomy, with Scer\GAL4hh-Gal4
abnormal neuroanatomy, with Scer\GAL4Mef2.247
abnormal neuroanatomy, with Scer\GAL4Mz19
abnormal neuroanatomy, with Scer\GAL4NP6658
abnormal neuroanatomy, with Scer\GAL4peb-GAL4
abnormal neuroanatomy, with Scer\GAL4ppk.PG
abnormal neuroanatomy | adult stage, with Hsap\RELAAD.R78H05, Scer\GAL4DBD.R31F09
abnormal neuroanatomy | adult stage, with Hsap\RELAAD.VT028327, Ncra\QFMz19, Scer\GAL4DBD.R22E04, Ten-mQUAS.cHa
abnormal neuroanatomy | adult stage, with Hsap\RELAAD.VT028327, Ncra\QFMz19, Scer\GAL4DBD.R22E04, Ten-mUAS.Tag:V5
abnormal neuroanatomy | adult stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
abnormal neuroanatomy | adult stage, with Scer\GAL4Mz19
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage, with Scer\GAL469B
abnormal neuroanatomy | embryonic stage, with Scer\GAL4prd.RG1
abnormal neuroanatomy | embryonic stage (with Ten-m05309)
abnormal neuroanatomy | embryonic stage (with Ten-mCB04632)
abnormal neuroanatomy | embryonic stage (with Ten-mΔ510)
abnormal neuroanatomy | P-stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
abnormal neuroanatomy | somatic clone, with Ncra\QFMz19.PH, Scer\GAL4Mz19, Ten-mGS9267
abnormal neuroanatomy | somatic clone, with Ncra\QFMz19.PH, Scer\GAL4Mz19, Ten-mQUAS.cHa
abnormal neuroanatomy | somatic clone, with Scer\GAL4Mz19
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during embryonic stage
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4hh-Gal4
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4NP6658
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4ppk.PG
abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4221
abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4arm.PU
abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4hh-Gal4
abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4NP6658
abdominal posterior ventral multidendritic neuron vdap | third instar larval stage, with Scer\GAL4221
adult antennal lobe, with Hsap\RELAAD.R78H05, Scer\GAL4DBD.R31F09
adult antennal lobe, with Hsap\RELAAD.VT028327, Ncra\QFMz19, Scer\GAL4DBD.R22E04, Ten-mQUAS.cHa
adult antennal lobe, with Hsap\RELAAD.VT028327, Ncra\QFMz19, Scer\GAL4DBD.R22E04, Ten-mUAS.Tag:V5
adult antennal lobe, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
adult antennal lobe, with Scer\GAL4Mz19
adult antennal lobe | P-stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
adult antennal lobe projection neuron DA1 lPN, with Scer\GAL4Mz19
adult antennal lobe projection neuron VA1d adPN, with Scer\GAL4Mz19
adult antennal olfactory receptor neuron, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
adult antennal olfactory receptor neuron | P-stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
adult olfactory receptor neuron Or67d, with Scer\GAL4Mz19
adult olfactory receptor neuron Or88a, with Hsap\RELAAD.R78H05, Scer\GAL4DBD.R31F09
antennal lobe glomerulus DA1 | adult stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
dendritic tree | third instar larval stage, with Scer\GAL4221
dendritic tree | third instar larval stage, with Scer\GAL4arm.PU
dendritic tree | third instar larval stage, with Scer\GAL4hh-Gal4
dendritic tree | third instar larval stage, with Scer\GAL4NP6658
dendritic tree | third instar larval stage, with Scer\GAL4ppk.PG
eye photoreceptor cell, with Scer\GAL4GMR.PF
eye photoreceptor cell | somatic clone
filamentous actin | somatic clone, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
interommatidial bristle, with Scer\GAL4GMR.PF
interommatidial bristle, with Scer\GAL4sca.PU
interommatidial bristle | increased number, with Scer\GAL4GMR.PF
interommatidial bristle | increased number, with Scer\GAL4sca.PU
interommatidial bristle | somatic clone
interommatidial bristle | somatic clone | increased number
larval intersegmental nerve | embryonic stage
larval intersegmental nerve | embryonic stage, with Scer\GAL469B
larval intersegmental nerve | embryonic stage, with Scer\GAL4prd.RG1
larval intersegmental nerve | embryonic stage (with Ten-m05309)
larval intersegmental nerve | embryonic stage (with Ten-mCB04632)
larval intersegmental nerve | embryonic stage (with Ten-mΔ510)
lens | somatic clone
neuron projection, with Hsap\RELAAD.VT028327, Ncra\QFMz19, Scer\GAL4DBD.R22E04, Ten-mQUAS.cHa
neuron projection, with Hsap\RELAAD.VT028327, Ncra\QFMz19, Scer\GAL4DBD.R22E04, Ten-mUAS.Tag:V5
neuron projection, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
neuron projection | adult stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
neuron projection | adult stage, with Scer\GAL4Mz19
neuron projection | P-stage, with Hsap\RELAAD.VT028327, Scer\GAL4DBD.R22E04
NMJ bouton, with Scer\GAL4Mef2.247
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4sca.PU
ommatidium | somatic clone
photoreceptor cell R7 | larval stage | somatic clone
presynaptic active zone | adult stage, with Scer\GAL4Mz19
pupa
synapse | adult stage, with Scer\GAL4Mz19
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\TENM2
14 of 14
Yes
Yes
Hsap\TENM1
13 of 14
No
Yes
Hsap\TENM3
13 of 14
No
Yes
Hsap\TENM4
13 of 14
No
Yes
Hsap\TNN
2 of 14
No
No
Hsap\TNR
2 of 14
No
No
Hsap\WIF1
2 of 14
No
No
2  
Hsap\DLL1
1 of 14
No
No
Hsap\DNER
1 of 14
No
No
Hsap\FAT1
1 of 14
No
No
Hsap\JAG1
1 of 14
No
No
0  
Hsap\JAG2
1 of 14
No
No
Hsap\LAMA5
1 of 14
No
No
Hsap\NELL2
1 of 14
No
Yes
Hsap\NOTCH1
1 of 14
No
No
Hsap\NOTCH2
1 of 14
No
No
Hsap\NOTCH3
1 of 14
No
No
Hsap\SCARF2
1 of 14
No
No
Hsap\TNC
1 of 14
No
No
Hsap\TNXB
1 of 14
No
No
Hsap\VWDE
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (8)
Rnor\Tenm2
14 of 14
Yes
Yes
Rnor\Tenm4
13 of 14
No
Yes
Rnor\Tenm3
12 of 14
No
Yes
Rnor\Tnr
2 of 14
No
No
Rnor\Fat1
1 of 14
No
No
Rnor\Tenm1
1 of 14
No
Yes
Rnor\Tnn
1 of 14
No
No
Rnor\Wif1
1 of 14
No
No
Mus musculus (laboratory mouse) (12)
Mmus\Tenm2
14 of 14
Yes
Yes
Mmus\Tenm1
13 of 14
No
Yes
Mmus\Tenm3
13 of 14
No
Yes
Mmus\Tenm4
13 of 14
No
Yes
Mmus\Fat1
1 of 14
No
No
Mmus\Krtap4-6
1 of 14
No
Yes
Mmus\Scarf2
1 of 14
No
No
Mmus\Tnc
1 of 14
No
No
Mmus\Tnn
1 of 14
No
No
Mmus\Tnr
1 of 14
No
No
Mmus\Tnxb
1 of 14
No
No
Mmus\Wif1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\tenm2
7 of 13
Yes
Yes
Xtro\tenm4
7 of 13
Yes
Yes
Xtro\tenm1
6 of 13
No
Yes
Xtro\tenm3
5 of 13
No
Yes
Xtro\crh
1 of 13
No
Yes
Xtro\fat1
1 of 13
No
No
Xtro\jag1
1 of 13
No
No
Xtro\megf10
1 of 13
No
No
Xtro\scarf1
1 of 13
No
Yes
Xtro\tmod2
1 of 13
No
No
Xtro\tnr
1 of 13
No
No
Xtro\ush2a
1 of 13
No
No
Danio rerio (Zebrafish) (15)
Drer\tenm2a
14 of 14
Yes
Yes
Drer\tenm1
13 of 14
No
Yes
Drer\si:dkey-237h12.3
12 of 14
No
Yes
Drer\tenm2b
12 of 14
No
Yes
Drer\tenm3
12 of 14
No
Yes
Drer\tenm4
12 of 14
No
Yes
Drer\tnca
2 of 14
No
Yes
Drer\tnr
2 of 14
No
No
Drer\fat1a
1 of 14
No
No
Drer\fn1b
1 of 14
No
Yes
Drer\jag1a
1 of 14
No
No
Drer\tncb
1 of 14
No
No
Drer\tnn
1 of 14
No
No
Drer\vwdel
1 of 14
No
No
Drer\wif1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\ten-1
13 of 14
Yes
Yes
Cele\C23H4.8
2 of 14
No
Yes
Cele\F40A3.2
2 of 14
No
Yes
Cele\T01D3.1
2 of 14
No
Yes
Cele\txt-5
2 of 14
No
Yes
Cele\C02B10.3
1 of 14
No
No
Cele\C05B5.5
1 of 14
No
Yes
Cele\C05B5.11
1 of 14
No
Yes
Cele\clec-78
1 of 14
No
No
Cele\F35D2.3
1 of 14
No
Yes
Cele\F46F11.7
1 of 14
No
No
Cele\F55H12.3
1 of 14
No
No
Cele\K03A11.5
1 of 14
No
Yes
Cele\pat-3
1 of 14
No
No
Cele\T12A7.2
1 of 14
No
Yes
Cele\T16G12.10
1 of 14
No
Yes
Cele\T25C12.3
1 of 14
No
Yes
Cele\T25F10.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP011034
12 of 12
Yes
Yes
Agam\AgaP_AGAP000461
5 of 12
No
No
Agam\AgaP_AGAP000117
2 of 12
No
No
Agam\AgaP_AGAP004154
1 of 12
No
No
Agam\AgaP_AGAP009762
1 of 12
No
No
Agam\AgaP_AGAP009763
1 of 12
No
No
Agam\AgaP_AGAP010049
1 of 12
No
No
Agam\AgaP_AGAP010233
1 of 12
No
No
Agam\AgaP_AGAP010940
1 of 12
No
No
Agam\AgaP_AGAP011593
1 of 12
No
No
Agam\AgaP_AGAP012386
1 of 12
No
No
Agam\INTB
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT5G42620
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ten-m. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (19)
Ten-a
12 of 13
shf
2 of 13
C901
1 of 13
crb
1 of 13
eater
1 of 13
eys
1 of 13
Itgbn
1 of 13
LRP1
1 of 13
mys
1 of 13
NimB1
1 of 13
NimB2
1 of 13
NimB4
1 of 13
NimB5
1 of 13
NimC1
1 of 13
NimC2
1 of 13
NimC4
1 of 13
sli
1 of 13
uif
1 of 13
wry
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TENM4; teneurin transmembrane protein 4
    model of  essential tremor 5
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Ten-mUAS.cHa
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Ten-mEY03921
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TENM2; teneurin transmembrane protein 2
    14 of 14
    610119
        TENM1; teneurin transmembrane protein 1
        13 of 14
        300588
            TENM3; teneurin transmembrane protein 3
            13 of 14
            610083
              TENM4; teneurin transmembrane protein 4
              13 of 14
              610084
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Ten-m
              enhanceable
              Cdc42
              (Xu et al., 2024)
              Ten-m
              suppressible
              gek
              (Xu et al., 2024)
              Ten-m
              enhanceable
              gek
              (Xu et al., 2024)
              Ten-m
              enhanceable
              Rac1
              (Xu et al., 2024)
              Ten-m
              suppressible
              Rac1
              (Xu et al., 2024)
              Ten-m
              suppressible
              RhoGAP100F
              (Xu et al., 2024)
              Ten-m
              enhanceable
              RhoGAP100F
              (Xu et al., 2024)
              Ten-m
              enhanceable
              Ten-a
              (Hong et al., 2012)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              hh
              enhanceable
              Ten-m
              (Levine et al., 1997)
              Ten-a
              enhanceable
              Ten-m
              (Hong et al., 2012)
              upd1
              enhanceable
              Ten-m
              (Mukherjee et al., 2006)
              External Data
              Subunit Structure (UniProtKB)
              Homodimer. Heterodimer with Ten-a. Interacts with Ten-a; the interaction occurs at the neuromuscular junction. Interacts with alpha-Spec and cher.
              (UniProt, O61307 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3L
              Recombination map
              3-47
              Cytogenetic map
              79D4-79E3
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              79D4-79E3
              Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              79E1-79E2
              (determined by in situ hybridisation)
              (Spradling et al., 1999, Baumgartner et al., 1994)
              79E-79E
              (determined by in situ hybridisation)
              (Levine et al., 1994)
              79E1-79E4
              (BDGP Project Members, 1994-1999)
              Experimentally Determined Recombination Data
              Location

              3-47

              (FlyBase, 2016)

              3-44.0

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (75)
              Genomic Clones (78)
              cDNA Clones (79)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                    Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      monoclonal

                      (Baumgartner et al., 1994, Levine et al., 1994)
                      Commercially Available Antibodies
                       
                      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          Ten-m instructs synaptic partner matching of projection neuron dendrites to the appropriate olfactory receptor neuron axon through homophilic attraction.

                          (Hong et al., 2012)

                          Ten-m loss of function mutations do not show a pair-rule segmentation phenotype. The pair-rule phenotype previously reported for a number of Ten-m mutations has been shown to be due to a mutation present on the balancer in the original stock.

                          (Zheng et al., 2011)

                          dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.

                          (Mukherjee et al., 2006)

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.

                          (Kiger et al., 2003)

                          It is possible that the mutation referred to as "l(3)00844" in FBrf0082995 is actually l(3)0086400864. Ten-m is at 79E whereas the insertion in FBrf0082995 is clearly shown as mapping to between 75C5-7 and 75F1, as does l(3)0086400864.

                          (Roote, 2003.11.4)

                          Ten-m encodes a type I transmembrane protein with the vast C-terminal portion in the intracellular space. The polypeptide undergoes multiple cleavages at discrete intracellular and extracellular sites and its extreme C-terminus undergoes either processing at a very large number of sites or programmed degradation. The polypeptide is presented at the cell surface as two subunits of previously cleaved protein joined by cysteine disulphide bridges and it has additional post-translational modifications.

                          (Dgany and Wides, 2002)

                          Ten-m has been characterised as a potential ligand of PS2 integrins by functional interaction in cell culture.

                          (Graner et al., 1998)

                          Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

                          (Harvie et al., 1998)

                          Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.

                          (Braun et al., 1997)

                          Genetics and molecular structure of Ten-m.

                          (Levine et al., 1997)

                          FlyBase curator comment: It is possible that the mutation referred to as "l(3)00844" is actually l(3)0086400864. Ten-m is at 79E whereas the insertion in FBrf0082995 is clearly shown as mapping to between 75C5-7 and 75F1, as does l(3)0086400864. See Roote, 2003.11.28, personal communication to FlyBase for explanation of this.

                          (Addison et al., 1995)

                          FlyBase curator comment: FBrf0214744 characterises new loss of function mutations in Ten-m and finds no evidence of a pair-rule segmentation phenotype, in contrast to previous reports. The authors show that the pair-rule phenotype previously reported for a number of Ten-m mutations (Ten-m05309, Df(3L)Ten-m-AL1 and Df(3L)Ten-m-AL29) was in fact due to a mutation present on the balancer in the original stock.

                          (FlyBase, 1992-)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Ten-m l(3)05301

                          (Beaton, 1999.12.12)

                          Source for merge of: Ten-m BcDNA:AT25108

                          (FlyBase, 1996-)
                          Additional comments

                          Source for merge of Ten-m BcDNA:AT25108 was a shared cDNA ( date:030728 ).

                          (FlyBase, 1996-)

                          Complementation tests show that the Ten-m locus is distinct from bch and l(3)7E103.

                          (Levine et al., 1994)
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: Ten-m CG5723

                          (Worley, 1999.11)
                          Nomenclature comments
                          Etymology

                          The name 'odd Oz' was suggested for this gene because of the 'odd' pair rule phenotype, and the observation that the mutant phenotype affects structures corresponding to the three gifts bestowed by the Wizard of Oz, namely heart, brain and nervous system (courage). FlyBase curator comment: FBrf0214744 has subsequently shown that loss of function Ten-m mutations do not have a pair-rule phenotype, and that the the pair-rule phenotype previously reported for a number of Ten-m mutations was in fact due to a mutation present on the balancer in the original stock.

                          (Levine et al., 1994)
                          Synonyms and Secondary IDs (34)
                          Reported As
                          Symbol Synonym
                          2017
                          (Harvie et al., 1998)
                          5301
                          (Harvie et al., 1998)
                          BcDNA:AT25108
                          CG11452
                          (Grieder et al., 2007)
                          CG5723
                          (Meadows, 2018.4.4, Lee et al., 2013, Christis and Munro, 2012, Perkins et al., 2009, Roos et al., 2005)
                          CT16449
                          (Hynes and Zhao, 2000)
                          Odz
                          (Tucker and Chiquet-Ehrismann, 2006)
                          Ten-M
                          (Seyres et al., 2016)
                          Ten-m
                          (Lyu et al., 2026, Chen et al., 2025, El-Danaf et al., 2025, Li et al., 2025, Lyu et al., 2025, Röper, 2025, Pignataro et al., 2024, Xu et al., 2024, Corthals et al., 2023, Fernandez-Gonzalez and Harris, 2023, Garcia-Vaquero et al., 2023, O'Farrell et al., 2023, Titlow et al., 2023, Zhao et al., 2023, Beaver et al., 2022, Gupta et al., 2022, Hultmark and Andó, 2022, Jauregui-Lozano et al., 2022, Everetts et al., 2021, Girard et al., 2021, Kamiyama et al., 2021, Michki et al., 2021, Pang et al., 2021, Yin et al., 2021, Cho et al., 2020, Feuillette et al., 2020, Paré and Zallen, 2020, Sharrock and Sanson, 2020, Baumgartner and Wides, 2019, Clark et al., 2019, FlyBase Genome Annotators, 2019-, Moreno-Salinas et al., 2019, Paré et al., 2019, Gene Disruption Project members, 2018-, Oriel and Lasko, 2018, Pai et al., 2018, Lou et al., 2017, Clandinin and Owens, 2016-, Green et al., 2016, Duff et al., 2015, Gene Disruption Project members, 2015-, Harris and Littleton, 2015, Sopko et al., 2015, Ashwal-Fluss et al., 2014, Dani et al., 2014, Hong and Luo, 2014, Lee et al., 2013, Saunders et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mosca et al., 2012, Nose, 2012, Tucker et al., 2012, Jungreis et al., 2011, Zheng et al., 2011, Wasbrough et al., 2010, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Grieder et al., 2007, Kinel-Tahan et al., 2007, Parrish et al., 2007, Rakovitsky et al., 2007, Zhang et al., 2007, Choksi et al., 2006, Haynes et al., 2006, Liebl et al., 2006, Mukherjee et al., 2006, Otsuna and Ito, 2006, Tucker and Chiquet-Ehrismann, 2006, Venken, 2006)
                          Ten-mc
                          (Egger et al., 2002)
                          Ten79E
                          Tenm
                          (Wides et al., 1996, Baumgartner, 1995.7.4, Chiquet-Ehrismann et al., 1995, Baumgartner et al., 1994, Erickson, 1993)
                          l(3)00844
                          (Addison et al., 1995)
                          l(3)05301
                          l(3)05309
                          (Braun et al., 1997)
                          l(3)rJ307
                          l(3)rL201
                          l(3)rP126
                          odd(Oz)
                          (Baumgartner, 1995.7.4)
                          odz
                          (Hunding and Baumgartner, 2017, Zheng et al., 2011, Kinel-Tahan et al., 2007, Rakovitsky et al., 2007, Wides et al., 1999, Wides et al., 1998, Levine et al., 1997, Levine et al., 1997, Wides, 1997.6.13, Wides, 1997.6.13, Wides, 1997.6.13, Wides, 1997.6.13, Wides, 1997.6.13, Wides et al., 1996, Levine et al., 1994)
                          odz/ten-m
                          (Dgany and Wides, 2002)
                          ten(m)
                          (Baumgartner, 1993.6.3)
                          ten-m
                          (Tlili et al., 2025, Fischer et al., 2024, DePew et al., 2019, Hunding and Baumgartner, 2017, Mosca and Luo, 2014, Hong et al., 2012, Mosca et al., 2012, Yassin et al., 2010, Zhang et al., 2008, Venken et al., 2006, Hynes and Zhao, 2000, Hynes and Zhao, 2000, Minet et al., 1999)
                          ten-m/odz
                          (Tucker and Chiquet-Ehrismann, 2006)
                          tenm
                          (Baumgartner et al., 1995, Chiquet-Ehrismann, 1995, Fessler et al., 1994, Gotwals et al., 1994, Baumgartner and Chiquet-Ehrismann, 1993)
                          Name Synonyms
                          Tenascin major
                          (Burnette et al., 2005, Mok et al., 2005)
                          Tenascin-major
                          (Zheng et al., 2011)
                          Teneurin
                          (Röper, 2025, Hong et al., 2012, Mosca et al., 2012)
                          Teneurin-m
                          (Hong, 2013)
                          odd Oz
                          (Kinel-Tahan et al., 2007, Rakovitsky et al., 2007, Tucker and Chiquet-Ehrismann, 2006, Levine et al., 1997, Levine et al., 1997)
                          odd-Oz
                          (Wides et al., 1998)
                          tenascin major
                          (Brown et al., 2000)
                          tenascin-like molecule major
                          (Tucker and Chiquet-Ehrismann, 2006)
                          tenascin-major
                          (Li et al., 2020, Zhang et al., 2008)
                          Secondary FlyBase IDs
                          • FBgn0010864
                          • FBgn0011500
                          • FBgn0011513
                          • FBgn0011526
                          • FBgn0011680
                          • FBgn0024864
                          • FBgn0037160
                          • FBgn0047332
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 76 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          PDB - An information portal to biological macromolecular structures
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          References (202)