TyrR, l(3)neo30, hono, Ocr, honoka
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Oct-TyrR using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Oct-TyrR in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
FlyBase Curator comment: The product of the CG7485 (FBgn0004514) gene has been characterized and referred to as both an "octopamine receptor" (e.g. FBrf0052683) and a "tyramine receptor" (e.g. FBrf0051655). Several other studies have explicitly referred to it as a mixed-type "octopamine/tyramine receptor" (e.g. FBrf0068659, FBrf0099466, FBrf0155846, FBrf0189828). The FlyBase symbol/name has been changed from 'TyrR/Tyramine receptor' to 'Oct-TyrR/Octopamine-Tyramine receptor' to reflect this.
Tyramine, rather than octopamine, is likely to be the true ligand of the TyrR product. Tyramine seems to function as a neuromodulator.
Mutants show defective olfactory behaviour.
The octopamine/tyramine receptor, when permanently expressed in a heterologous cell line both inhibits adenylate cyclase activity and leads to elevation of intracellular calcium levels by separate G-protein coupled pathways.
'honoka' means 'faint smell' in Japanese.