FlyBase Gene Report: Dmel\Oct-TyrR

General Information

Symbol

Dmel\Oct-TyrR

Species

D. melanogaster

Name

Octopamine-Tyramine receptor

Annotation Symbol

CG7485

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004514

Gene Model Status

Current

Stock Availability

103 publicly available

Gene Summary

Octopamine-Tyramine receptor (Oct-TyrR) encodes a Tyramine 1 class receptor. When heterologously expressed it shows agonist specific coupling, with tyramine being more potent than octopamine in the inhibition of adenylyl cyclase activity and octopamine being more potent than tyramine in the release of calcium from internal stores. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

TyrR, l(3)neo30, Ocr, hono, TAR1

Key Links

Genomic Location

Cytogenetic map

79B1-79B2

Sequence location

3L:22,035,003..22,065,279 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:22035003..22065279

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables G protein-coupled amine receptor activity

inferred from direct assay

(Chatwin et al., 2003, Robb et al., 1994)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled amine receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002798477

(GO Reference Genome Project, 2011-)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

enables octopamine receptor activity

inferred from electronic annotation with InterPro:IPR002002

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in octopamine or tyramine signaling pathway

inferred from direct assay

(Chatwin et al., 2003, Robb et al., 1994)

inferred from mutant phenotype

(Nagaya et al., 2002)

involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

inferred from direct assay

(Robb et al., 1994)

involved_in sensory perception of smell

inferred from mutant phenotype

(Kutsukake et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR002002

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Chatwin et al., 2003, Robb et al., 1994)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR002002, InterPro:IPR017452

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:5-HT7; FB:FBgn0004573

(Saudou et al., 1990)

inferred from sequence or structural similarity with UniProtKB:P08908

(Saudou et al., 1990)

inferred from sequence or structural similarity with FLYBASE:mAChR-A; FB:FBgn0000037

(Arakawa et al., 1990)

inferred from sequence or structural similarity with UniProtKB:P08588

(Arakawa et al., 1990)

Gene Group (FlyBase)

TYRAMINE RECEPTORS

OCTOPAMINE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (P22270)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TYRAMINE RECEPTORS -: Tyramine receptors belong to the Class A GPCR family. In mammalian systems, tyramine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).
OCTOPAMINE RECEPTORS -: Octopamine receptors belong to the Class A GPCR family. In mammalian systems, octopamine is a member of the trace amines, but in insects octopamine and tyramine are thought to be the main neurotransmitters. (Adapted from PMID:17088868, FBrf0214056 and FBrf0190865).

Protein Function (UniProtKB)

Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.

(UniProt, P22270)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Ocr: Octopamine receptor (J.C. Hall)

Independent cDNAs were cloned into expression vectors and transfected into CHO-1 (Arakawa et al., 1990) or Cos-7 (Saudou et al., 1990) cells. Membranes from such cells had high-affinity binding activity to the adrenergic receptor agonist yohimbine; other agonists or antagonists used to compete with this substance showed the octopamine analog, synephrine, to have the highest agonist affinity, higher than octopamine itself; these results along with others which showed greater affinity of the cloned/transduced protein for yohimbine and chlorpromazine than for metoclopramide, suggested that this Drosophila receptor is an "octopamine-1" subtype (Arakawa et al., 1990). Membranes preparations from the Cos-cell transfectants also had high affinity for yohimbine, and tyramine (e.g. greater than octopamine), suggesting to Saudou et al. (1990) that this Drosophila gene encodes a tyramine receptor. Stably transfected mouse cell lines were also made (Saudou et al., 1990); additions of monoamines to them (e.g. tyramine, octopamine) do not by themselves lead to changes in cAMP levels, but forskolin-elicited cAMP increases were reduced by added tyramine (which was more effective than octopamine). Rough anatomical localization revealed a head-enriched mRNA (3.6 kb: Arakawa et al., 1990; 3.5 kb: Saudou et al., 1990).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Oct-TyrR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P22270)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Oct-TyrR-RA

FBtr0078479

NM_079695

3682

601

Oct-TyrR-RB

FBtr0301930

NM_001170023

3675

601

Additional Transcript Data and Comments

Reported size (kB)

3.6 (northern blot)

(Arakawa et al., 1990)

4.3 (northern blot)

(Saudou et al., 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Oct-TyrR-PA

FBpp0078132

64.7

601

8.09

FBpp0291142

64.7

601

8.09

P22270

NP_001163494

ACZ94765

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

601 aa isoforms: Oct-TyrR-PA, Oct-TyrR-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

601 (aa); 65 (kD predicted)

(Arakawa et al., 1990)

601 (aa)

(Saudou et al., 1990)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Oct-TyrR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Oct-TyrR_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.53

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Saudou et al., 1990)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval brain

(El-Kholy et al., 2015)

embryonic/larval tracheal section

(El-Kholy et al., 2015)

embryonic/larval Malpighian tubule

(El-Kholy et al., 2015)

adult stage

adult Malpighian tubule

(Blumenthal, 2003)

adult brain

(El-Kholy et al., 2015)

male reproductive system

(El-Kholy et al., 2015)

Additional Descriptive Data

TyrR transcripts are relatively rare and are enriched in adult heads relative to adult bodies.

(Arakawa et al., 1990)

TyrR transcripts are detected in adult heads but not bodies.

(Saudou et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Chatwin et al., 2003, Robb et al., 1994)

Expression Deduced from Reporters

Reporter: P{Oct-TyrR-GAL4.E}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

primary tracheal branch

(El-Kholy et al., 2015)

embryonic/larval aorta | dorsal | intense

(El-Kholy et al., 2015)

embryonic/larval salivary gland

(El-Kholy et al., 2015)

spiracular opening | intense

(El-Kholy et al., 2015)

larval peripheral nervous system | intense

(El-Kholy et al., 2015)

larval central nervous system | restricted

(El-Kholy et al., 2015)

Reporter: PBac{Oct-TyrR-GAL4.S}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

neuron | subset of larval ventral nerve cord

(Stowers, 2011)

motor neuron of larval ventral nerve cord

(Stowers, 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Oct-TyrR in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Oct-TyrR

View exonic expression by tissue for Dmel\Oct-TyrR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42452/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004514

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004514

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004514

Flygut - An atlas of the Drosophila adult midgut

FBgn0004514

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Oct-TyrR

Transgenic constructs containing regulatory region of Oct-TyrR

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene not disrupted in

Df(3L)Pc-MK

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Oct-TyrR^neo30

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Oct-TyrR^GD13188

viable, with Scer\GAL4^Mef2.PR

Oct-TyrR^GD13188

viable, with Scer\GAL4^pnr-MD237

Oct-TyrR^GD13188

viable, with Scer\GAL4^tin.CΔ4

Oct-TyrR^GD13188

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal locomotor behavior | larval stage

Oct-TyrR^hono

abnormal neurophysiology

abnormal sleep | adult stage

Oct-TyrR^KOGal4

abnormal smell perception

Phenotype manifest in

Allele

neuromuscular junction

Oct-TyrR^hono

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (129)

Hsap\HTR1A

4 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\BDKRB1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CCR8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CXCR2

1 of 14

Yes

Hsap\CYSLTR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\F2R

1 of 14

Yes

Hsap\F2RL1

1 of 14

Yes

Hsap\GHSR

1 of 14

Hsap\GPBAR1

1 of 14

Yes

Hsap\GPR4

1 of 14

Yes

Hsap\GPR12

1 of 14

Yes

Hsap\GPR21

1 of 14

Hsap\GPR45

1 of 14

Yes

Hsap\GPR52

1 of 14

Hsap\GPR61

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR148

1 of 14

Hsap\GPR161

1 of 14

Yes

Hsap\GPR173

1 of 14

Yes

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OR1L1

1 of 14

Yes

Hsap\OR1M1

1 of 14

Yes

Hsap\OR14I1

1 of 14

Yes

Hsap\P2RY8

1 of 14

Yes

Hsap\PROKR1

1 of 14

Yes

Hsap\PROKR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (66)

Rnor\Htr1a

4 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cckar

1 of 14

Rnor\Ccr3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gpr21

1 of 14

Rnor\Gpr45

1 of 14

Yes

Rnor\Gpr83

1 of 14

Rnor\Gpr84

1 of 14

Rnor\Gpr101

1 of 14

Yes

Rnor\Gpr161

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Oprk1

1 of 14

Rnor\Prokr2

1 of 14

Yes

Rnor\Rrh

1 of 14

Rnor\S1pr1

1 of 14

Yes

Rnor\S1pr3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (67)

Mmus\Htr1a

4 of 14

Yes

Mmus\Adra2a

3 of 14

Mmus\Adra2c

3 of 14

Mmus\Htr1d

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Drd5

1 of 14

Mmus\Galr2

1 of 14

Mmus\Gpbar1

1 of 14

Yes

Mmus\Gpr21

1 of 14

Mmus\Gpr45

1 of 14

Yes

Mmus\Gpr52

1 of 14

Mmus\Gpr84

1 of 14

Mmus\Gpr101

1 of 14

Yes

Mmus\Gpr161

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Olfr1377

1 of 14

Yes

Mmus\Oprk1

1 of 14

Mmus\S1pr1

1 of 14

Yes

Mmus\S1pr3

1 of 14

Yes

Mmus\S1pr4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tacr1

1 of 14

Mmus\Tacr2

1 of 14

Mmus\Tacr3

1 of 14

Xenopus tropicalis (Western clawed frog) (112)

Xtro\adra2b

3 of 13

Yes

Xtro\adra2c

3 of 13

Yes

Xtro\htr1a

3 of 13

Yes

Xtro\adra1a

2 of 13

Xtro\adra1d

2 of 13

Xtro\ackr4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\f2rl1

1 of 13

Yes

Xtro\f2rl3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gpr6

1 of 13

Yes

Xtro\gpr65

1 of 13

Yes

Xtro\gpr78

1 of 13

Yes

Xtro\gpr83

1 of 13

Xtro\gpr148

1 of 13

Xtro\gpr161

1 of 13

Yes

Xtro\gpr173

1 of 13

Yes

Xtro\gpr176

1 of 13

Yes

Xtro\hkdc1

1 of 13

Xtro\hrh4.b2

1 of 13

Xtro\hrh4.d1

1 of 13

Yes

Xtro\hrh4.g3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100495677

1 of 13

Yes

Xtro\LOC100496229

1 of 13

Yes

Xtro\LOC100498398

1 of 13

Yes

Xtro\LOC101734771

1 of 13

Xtro\LOC116411706

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\opnpl [provisonal]

1 of 13

Xtro\oprk1

1 of 13

Xtro\p2ry4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rho

1 of 13

Yes

Xtro\s1pr5

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (118)

Drer\adra2a

4 of 14

Yes

Drer\adra2b

4 of 14

Yes

Drer\adra2c

4 of 14

Yes

Drer\adra2da

4 of 14

Yes

Drer\adra2db

4 of 14

Yes

Drer\htr1aa

4 of 14

Yes

Drer\LOC100330650

4 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\gpr52

1 of 14

Drer\gpr101

1 of 14

Yes

Drer\gpr161a

1 of 14

Yes

Drer\gpr161b

1 of 14

Yes

Drer\gpr183a

1 of 14

Yes

Drer\hrh2a

1 of 14

Drer\hrh3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100331077

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC101886918

1 of 14

Yes

Drer\LOC108179103

1 of 14

Drer\lpar1

1 of 14

Yes

Drer\lpar6a

1 of 14

Yes

Drer\ltb4r2a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\s1pr2

1 of 14

Yes

Drer\s1pr3a

1 of 14

Yes

Drer\s1pr4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (50)

Cele\ser-2

9 of 14

Yes

Cele\ser-4

4 of 14

Cele\tyra-3

4 of 14

Yes

Cele\tyra-2

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (63)

Agam\GPRTYR

12 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Oct-TyrR. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (53)

5 of 13

5 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rh3

1 of 13

Rh6

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

HTR1A; 5-hydroxytryptamine receptor 1A

model of vesicoureteral reflux

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Oct-TyrR^JF02967

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HTR1A; 5-hydroxytryptamine receptor 1A

4 of 14

109760

PERIODIC FEVER, MENSTRUAL CYCLE-DEPENDENT

vesicoureteral reflux

ADRA2A; adrenoceptor alpha 2A

3 of 14

104210

LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 8; FPLD8

ADRA2B; adrenoceptor alpha 2B

3 of 14

104260

ADRA2C; adrenoceptor alpha 2C

3 of 14

104250

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004514

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Adrenaline,noradrenaline inhibits insulin secretion

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

79B1-79B2

Sequence location

3L:22,035,003..22,065,279 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

79B1-79B2

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

79C-79D

(determined by in situ hybridisation)

(Kutsukake et al., 2000)

79D1-79D4

(determined by in situ hybridisation)

(Spradling et al., 1999)

79D1-79D4

(BDGP Project Members, 1994-1999)

99A10-99B1

(determined by in situ hybridisation)

(Arakawa et al., 1990)

79D-79D

(determined by in situ hybridisation)

(Cooley et al., 1988)

Stated as 99A10--B1, subsequently revised (see FBrf0126774).

(Arakawa et al., 1990)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (103)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12157

P{VT034630-GAL4}attP2

12440

P{VT034622-GAL4}attP2

12703

P{VT034615-GAL4}attP2

12945

P{VT034628-GAL4}attP2

13161

P{VT034631-GAL4}attP2

13493

P{VT034623-GAL4}attP2

13769

P{VT034627-GAL4}attP2

15469

P{VT034616-GAL4}attP2

15534

P{GMR68B05-GAL4}attP2

15694

P{VT034628-lexA}attP40

15870

P{VT034616-lexA}attP40

16188

PBac{GMR68A06-lexA}VK00027

More stocks available...

Genomic Clones (32)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP02940

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004514

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004514

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Tyramine, rather than octopamine, is likely to be the true ligand of the TyrR product. Tyramine seems to function as a neuromodulator.

(Nagaya et al., 2002)

Mutants show defective olfactory behaviour.

(Kutsukake et al., 2000)

The octopamine/tyramine receptor, when permanently expressed in a heterologous cell line both inhibits adenylate cyclase activity and leads to elevation of intracellular calcium levels by separate G-protein coupled pathways.

(Robb et al., 1994)

Identification: On the basis of sequence similarity to the human Β₂-adrenergicreceptor. Sequence and pharmacological considerations indicate that the TyrR product may be an evolutionary precursor to mammalian adrenergic receptors.

(Arakawa et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: Ocr CG7485

(Misra, 2000.4.14)

Source for merge of: Ocr l(3)neo30

(Kutsukake et al., 2000)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: hono l(3)neo30

(Kutsukake et al., 2000)

Source for identity of: Oct-TyrR TyrR

(FlyBase, 2009-)

Nomenclature comments

The product of the CG7485 (FBgn0004514) gene has been characterized and referred to as both an "octopamine receptor" (e.g. FBrf0052683) and a "tyramine receptor" (e.g. FBrf0051655). Several other studies have explicitly referred to it as a mixed-type "octopamine/tyramine receptor" (e.g. FBrf0068659, FBrf0099466, FBrf0155846, FBrf0189828). The FlyBase symbol/name has been changed from 'TyrR/Tyramine receptor' to 'Oct-TyrR/Octopamine-Tyramine receptor' to reflect this.

(FlyBase, 2009-)

Etymology

'honoka' means 'faint smell' in Japanese.

(Kutsukake et al., 2000)

Synonyms and Secondary IDs (34)

Reported As

Symbol Synonym

CG7485

(Mao et al., 2024, Ward and Moehring, 2021, Jayakumar et al., 2016, Bayliss et al., 2013, Stowers, 2011, Perkins et al., 2009, Hauser et al., 2006, Cazzamali et al., 2005, Evans and Maqueira, 2005)

DmTAR1

(Qi et al., 2017, Bayliss et al., 2013)

DmTyrR

(Roeder et al., 2003)

Dmoct/tyr

(Blenau and Baumann, 2001)

DrmOTR

(Cazzamali et al., 2005)

OA-R

(Buchner, 1991)

OAR_DROME

(Maqueira et al., 2005)

OTR

(Cazzamali et al., 2005)

OcR

(Chatwin et al., 2003)

Ocr

(Brody and Cravchik, 2000, Coulier et al., 2000, Endo et al., 2000)

Oct/Tyr

(Bazargani and Attwell, 2017)

OctoR1

(Hall et al., 1991)

OctyR99AB

(Feng et al., 1996)

TAR1

(Zhang et al., 2023, Finetti et al., 2021, Bayliss et al., 2013)

TYR

(Han et al., 1998)

TyR

Tyr

(Zumstein et al., 2004)

Tyr-OctR

(Youn et al., 2018)

Tyr-dro

(Saudou et al., 1990)

TyrR

(El-Kholy et al., 2015, Stowers, 2011, Pospisilik et al., 2010, Anaka et al., 2008, Enan, 2005)

hono

(Schützler et al., 2019, Hirsh and Burnette, 2001.5.9, Endo et al., 2000)

l(3)neo30

(Kutsukake et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Cooley et al., 1988)

tar1

(Li et al., 2017)

Name Synonyms

Oct/Tyr receptor

(Bayliss et al., 2013)

Octopamine receptor

Octopamine receptor 1

(Hall et al., 1991)

Octopamine-Tyramine receptor

Octopamine/Tyramine receptor

(Bayliss et al., 2013)

Tyramine receptor

(Anaka et al., 2008, Saudou et al., 1990)

Tyramine-receptor

honoka

(Schützler et al., 2019, Kutsukake et al., 2000)

octopamine/tyramine receptor

(Ma et al., 2016, Faisal et al., 2014, Cazzamali et al., 2005)

tyramine receptor

(Stowers, 2011, Zumstein et al., 2004, Blumenthal, 2003)

Secondary FlyBase IDs

FBgn0002983
FBgn0004109
FBgn0011463
FBgn0037148

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42452

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P22270

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P22270

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

E1JI27

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P22270

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42452/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004514

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004514

FlyMine - An integrated database for Drosophila genomics

FBgn0004514

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7485

MARRVEL_MODEL - MARRVEL (model organism gene)

42452

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004514

DroID - A comprehensive database of gene and protein interactions.

FBgn0004514

DRSC - Results frm RNAi screens

FBgn0004514

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Oct-TyrR_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004514

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004514

Flygut - An atlas of the Drosophila adult midgut

FBgn0004514

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004514

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004545

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Adrenaline,noradrenaline inhibits insulin secretion

References (130)

The following external sites may use different assemblies or annotations than FlyBase.

-0.53

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