Gad, glutamic acid decarboxylase, glutamatic acid decarboxylase, DGad1, l(3)64An
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gad1 using the Feature Mapper tool.
Gad1 protein is expressed in both the anterior and posterior rings of the ellipsoid body.
Most, but not quite all, local interneurons of the adult antennal lobe express Gad1.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gad1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Gad1 l(3)64An
All detectable embryonic GABA is produced by the Gad1 enzyme. Onset of detectable GABA production in the embryonic CNS occurs late in neurogenesis and is tightly regulated by a suppression of Gad1 downstream of Gad1 translation. GABA expression in primary cell cultures is influenced by K+. Suppression of GABA in chronically high K+ is independent of synaptic release. The negative regulation of Gad1 can be overridden by drugs known to elevate intracellular free Ca2+.
Cloned by cross-hybridization with feline GAD-encoding gene. The structural gene for glutamic acid decarboxylase. Cloned by cross-hybridization with feline GAD-encoding gene. Gad probes detect putative GAD-encoding 3.1-kb mRNA, from 4-8 h of embryogenesis to adulthood; a 2.6-kb RNA was also found, in embryos and pupae only; in situ hybridization detects the RNA(s) in widely, but not uniformly, distributed CNS cortical regions (of adult heads and larvae), with no detectable signals in non-neural tissues.