a vescular protein that participates in the regulation of neurotransmitter release - interacts with the cytoskeleton to regulate the number of synaptic vesicles available for release via exocytosis - promotes vesicle reuptake and reserve pool formation upon intense stimulation
Stop-codon suppression supported by data in FBrf0216884.
Stop-codon suppression (UAG) postulated; FBrf0087510.
Gene model reviewed during 5.44
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Gene model reviewed during 6.19
None of the polypeptides share 100% sequence identity.
Identified in a complex with Syt1 and nwk.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Syn using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Syn in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Syn regulates activity-dependent outgrowth of synaptic boutons at the neuromuscular junction.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Syn is cloned and characterised, a 309 amino acid domain shows 50% identity to the C domain of vertebrate synapsins.
The predicted amino acid sequence of the Syn gene product displays significant homology to the synaptic vesicle associated protein Synapse I from vertebrates.