FlyBase Gene Report: Dmel\bgcn

General Information

Symbol

Dmel\bgcn

Species

D. melanogaster

Name

benign gonial cell neoplasm

Annotation Symbol

CG30170

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004581

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

benign gonial cell neoplasm (bgcn) encodes an RNA-binding protein involved in germline stem cell lineage differentiation. It forms a translational repressor complex with the product of bam in ovaries and with the products of bam and tut in testis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

b(2)gcn, PNBP, pep

Key Links

Genomic Location

Cytogenetic map

60A4-60A4

Sequence location

2R:23,853,270..23,858,921 [-]

Recombination map

2-105

RefSeq locus

NT_033778 REGION:23853270..23858921

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables mRNA regulatory element binding translation repressor activity

inferred from direct assay

(Shen et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

NOT enables helicase activity

inferred from key residues

(Ohlstein et al., 2000)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in cell competition in a multicellular organism

inferred from mutant phenotype

(Jin et al., 2008)

involved_in germ-line stem cell population maintenance

inferred from direct assay

(Li et al., 2009)

involved_in male germline stem cell symmetric division

inferred from mutant phenotype

(Jin et al., 2008)

involved_in negative regulation of translation

inferred from mutant phenotype

(Chen et al., 2014)

involved_in oogenesis

inferred from high throughput mutant phenotype

(Schupbach and Wieschaus, 1991)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in cystoblast division

traceable author statement

(Williamson and Lehmann, 1996)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

UNCLASSIFIED PSEUDOENZYMES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED PSEUDOENZYMES -: This group comprises pseudoenzymes that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Forms a complex with tut and bam involved in 3'UTR-dependent post-transcriptional repression of several 3'-RNA processing factors, which promotes germline stem cell lineage differentiation and mitosis-to-meiosis transition (PubMed:25412508, PubMed:28190776). Part of a complex with bam involved in 3'-UTR-dependent translational repression of a subset of mRNAs, including those for mei-P26, nanos and shg/E-cadherin; may act as a promiscuous RNA-binding protein tethering bam to its target mRNAs (PubMed:19470484, PubMed:19556547, PubMed:23122292, PubMed:23526974). Required for regulating the progression of gonialblast cells through transit amplification and differentiation into gametes (PubMed:9334284).

(UniProt, Q9W1I2)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

bgcn: benign gonial cell neoplasm

Gametocyte differentiation defective; gonial proliferation unchecked; gonads of both males and females become engorged with gonial cells. Ovarioles appear sausage like; testes smaller than normal. Autonomous in transplants of young adult ovaries and testes into body cavity of wild-type females.

pep: peppercorn (T. Schupbach)

Female sterile; homozygous females contain many small egg chambers in their ovaries, which seem blocked in early stages of oogenesis. Follicle cells nevertheless synthesize a very small, round chorion around these egg chambers, giving them the appearance of small round peppercorns.

Summary (Interactive Fly)

cofactor of Bag of marbles that directly inhibits Pumilio repression of Nanos mRNA activity to promote differentiation of germ line stem cells

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\bgcn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W1I2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.52

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

bgcn-RA

FBtr0072232

NM_079108

4159

1215

bgcn-RB

FBtr0344878

NM_001299858

4144

1210

Additional Transcript Data and Comments

Reported size (kB)

4.1 (northern blot)

(Ohlstein et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

bgcn-PA

FBpp0072141

139.3

1215

7.15

FBpp0311191

138.7

1210

7.21

A0A0B4LGG1

NP_001286787

AHN56582

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1215 (aa); 139 (kD)

(Ohlstein et al., 2000)

Comments

External Data

Subunit Structure (UniProtKB)

Part of a complex composed of at least mei-P26, bam, bgcn and Sxl; this complex is involved in translational repression of nanos mRNA (PubMed:23526974). Interacts with bam (via C-terminus); the interaction is direct (PubMed:19470484, PubMed:19556547, PubMed:23122292, PubMed:23526974, PubMed:25412508). Interacts with mei-P26; the interaction is direct and does not require bam (PubMed:23526974). Weakly interacts with wh/wuho; this interaction may be required for the function or formation of the mei-P26-bgcn-bam-Sxl complex (PubMed:31941704). Part of a complex composed of at least tut, bam and bgcn; complex formation does not require RNA (PubMed:25412508). Interacts with tut; the interaction is indirect and is mediated by bam (PubMed:25412508). As part of the bam-bgcn-tut complex associates with twin; may recruit the CCR4-NOT1 deadenylation complex to mRNA 3'UTRs to mediate post-transcriptional regulation of expression (PubMed:28190776).

(UniProt, Q9W1I2)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bgcn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bgcn_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.79

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

gonad

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Ohlstein et al., 2000)

adult stage & oogenesis

germarium

(Ohlstein et al., 2000)

cyst cell of ovary

(Ohlstein et al., 2000)

female germline stem cell

(Ohlstein et al., 2000)

cystoblast

(Ohlstein et al., 2000)

Additional Descriptive Data

bgcn transcripts are abundant in males and very rare in females. By in sity hybridization, they are detected in 5-8 cells at the tip of the germarium. The expression occurs in the germline stem cells, the cystoblasts, and perhaps very young cystocytes.

(Ohlstein et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bgcn in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bgcn

View exonic expression by tissue for Dmel\bgcn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004581

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47873/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004581

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004581

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004581

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30170

Flygut - An atlas of the Drosophila adult midgut

FBgn0004581

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\bgcn

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bgcn

Transgenic constructs containing regulatory region of bgcn

Aberrations (Deficiencies and Duplications) ( 8 )

Inferred from experimentation ( 8 )

Gene disrupted in

Df(2R)b23

(Munn and Steward, 2000, Ohlstein et al., 2000)

Df(2R)BSC600

(Christensen et al., 2008.9.3)

Df(2R)BSC610

(Christensen et al., 2008.9.3)

Df(2R)BSC660

(Christensen et al., 2008.12.28)

Df(2R)BSC695

(Christensen et al., 2008.12.28)

Df(2R)bw-D23

(Schupbach and Wieschaus, 1991)

Df(2R)bw-S46

(Schupbach and Wieschaus, 1991)

Gene not disrupted in

Df(2R)OV1

(Ohlstein et al., 2000)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Scer\GAL4^Mef2.PR

bgcn^GD10012

viable, with Scer\GAL4^pnr-MD237

bgcn^GD10012

viable, with Scer\GAL4^tin.CΔ4

bgcn^GD10012

Sterility

Allele

female sterile

female sterile (with bgcn¹)

bgcn^z2-1748

female sterile (with bgcn^z2-1748)

bgcn¹

female sterile | recessive

male sterile | recessive

Other Phenotypes

Allele

abnormal cytokinesis

bgcn^QS2

abnormal meiotic cell cycle

bgcn^QS2

hyperplasia

bgcn^QS2

increased cell number

bgcn²

increased cell number | germline clone | oogenesis

bgcn¹

increased cell number | germline clone | oogenesis (with bgcn¹)

bgcn^MI06696

increased cell number | germline clone | oogenesis (with bgcn^MI06696)

bgcn¹

increased cell number | somatic clone | spermatogenesis

bgcn^QS2

Phenotype manifest in

Allele

cyst cell of ovary

bgcn¹

female germline cell | germline clone | increased number

bgcn¹

female germline cell | germline clone | increased number (with bgcn¹)

bgcn^MI06696

female germline cell | germline clone | increased number (with bgcn^MI06696)

bgcn¹

female germline stem cell

bgcn^QS2

female germline stem cell | germline clone

fusome

bgcn¹

male germline cyst | somatic clone | spermatogenesis

bgcn^QS2

male germline stem cell

bgcn^QS2

ovary | adult stage

stem cell fusome

bgcn^QS2

testis

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\YTHDC2

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Ythdc2

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Ythdc2

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (15)

Xtro\ythdc2

3 of 13

Yes

Xtro\gnl3l

2 of 13

Xtro\XB5817455

2 of 13

Yes

Xtro\ankh

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\sirt3.2

1 of 13

Xtro\tdrd9

1 of 13

Xtro\vgll4

1 of 13

Yes

Danio rerio (Zebrafish) (16)

Drer\ythdc2

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\F52B5.3

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP007953

5 of 12

Yes

Agam\AgaP_AGAP008081

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (23)

Atha\HVT1

3 of 13

Yes

Atha\NIH

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\DHR2

2 of 13

Yes

Scer\ECM16

2 of 13

Yes

Scer\PRP2

2 of 13

Yes

Scer\PRP16

2 of 13

Yes

Scer\PRP43

2 of 13

Yes

Scer\YLR419W

2 of 13

Yes

Scer\PRP22

1 of 13

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\prh1

2 of 12

Yes

Spom\prp22

2 of 12

Yes

Spom\prp43

2 of 12

Yes

Spom\SPBC15C4.05

2 of 12

Yes

Spom\ucp12

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\hrpA

1 of 11

Yes

Ecol\hrpB

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:bgcn. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

CG8915

3 of 13

ath

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

mle

2 of 13

pea

2 of 13

Prp16

2 of 13

Rhau

2 of 13

spn-E

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

bgcn^GD10012

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Linsalata et al., 2019)

bgcn^KK106752

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Malik et al., 2021, Linsalata et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

YTHDC2; YTH N6-methyladenosine RNA binding protein C2

4 of 14

616530

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bgcn - Sxl

anti tag coimmunoprecipitation, anti tag western blot, molecular sieving, western blot

(Malik et al., 2017, Li et al., 2013)

bgcn - bam

pull down, anti tag western blot, anti tag coimmunoprecipitation, two hybrid, three hybrid, molecular sieving, western blot, bimolecular fluorescence complementation, fluorescence microscopy

(Shan et al., 2017, Flores et al., 2015, Chen et al., 2014, Pan et al., 2014, Li et al., 2013, Insco et al., 2012, Kim et al., 2010, Li et al., 2009, Shen et al., 2009)

bgcn - mei-P26

pull down, anti tag western blot, anti tag coimmunoprecipitation, molecular sieving, western blot, two hybrid, anti bait coimmunoprecipitation

(Malik et al., 2017, Li et al., 2013, Insco et al., 2012)

bgcn - pum

bimolecular fluorescence complementation, fluorescence microscopy, three hybrid

(Kim et al., 2010)

bgcn - tut

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2014)

bgcn - twin

anti tag coimmunoprecipitation, anti tag western blot

(Fu et al., 2015)

bgcn - wuho

anti tag coimmunoprecipitation, western blot

(Rastegari et al., 2020)

RNA-protein

Physical Interaction

Assay

References

bgcn - Mad

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Malik et al., 2019)

bgcn - mei-P26

pull down, anti tag western blot, anti tag coimmunoprecipitation, molecular sieving, western blot, two hybrid, anti bait coimmunoprecipitation

(Malik et al., 2017, Li et al., 2013, Insco et al., 2012)

bgcn - nanos

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Malik et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bgcn|hpo

suppressible

AGO1

(Zhang et al., 2024)

bgcn

suppressible

AGO1

(Zhang et al., 2024)

bgcn

suppressible

mir-ban

(Zhang et al., 2024)

suppressible

(Jin et al., 2008)

suppressible

(Gilboa et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bam

enhanceable

bgcn

(Flores et al., 2015, Ohlstein et al., 2000)

suppressible

(Li et al., 2009)

suppressible

(Ghosh et al., 2014)

tut

enhanceable

bgcn

(Chen et al., 2014)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9W1I2 )

Linkouts

BioGRID - A database of protein and genetic interactions.

71021

DroID - A comprehensive database of gene and protein interactions.

FBgn0004581

MIST (genetic) - An integrated Molecular Interaction Database

47873

MIST (protein-protein) - An integrated Molecular Interaction Database

47873

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-105

Cytogenetic map

60A4-60A4

Sequence location

2R:23,853,270..23,858,921 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A4-60A4

Limits computationally determined from genome sequence between P{lacW}eIF6^k13214 and P{lacW}ken^k11035&P{EP}CG17658^EP730

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60A3-60A3

(Ohlstein, 2000.4.13)

60A-60A

(determined by in situ hybridisation)

(Ohlstein et al., 2000)

Experimentally Determined Recombination Data

Location

2-105

(FlyBase, 2016)

2-109.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

(Munn and Steward, 2000)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

6054

bgcn¹/CyO, P{sevRas1.V12}FK1

40815

y¹ w^*; Mi{MIC}bgcn^MI06696

20106

y¹ w^67c23; P{EPgy2}bgcn^EY00974

14687

y¹ w^67c23; P{SUPor-P}bgcn^KG08129

Kyoto

108568

bgcn¹/SM5

101302

Adc^b-1 bgcn¹ / SM1

101843

w¹ ; Adc^b-1 bgcn¹ / SM1

102021

w¹ ; Adc^b-1 bgcn¹ / SM6a ; TM6B

30170R-1

30170R-2

v108334

v25591

w¹¹¹⁸; P{GD10012}v25591

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT03323

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004581

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004581

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

bgcn is essential for the localization of bam protein to the fusome.

(Lavoie et al., 1999)

bam and bgcn cooperatively regulate cystoblast differentiation by controlling localization of bam protein to the fusome.

(Lavoie et al., 1999)

Germ cells lacking bgcn become trapped in a stem cell-like state.

(Lavoie et al., 1999)

Mosaic analysis demonstrates bam and bgcn act autonomously in the germline to restrict germ cell proliferation during spermatogenesis. Results suggest bam and bgcn regulate progression through the male germline stem cell lineage by cell-intrinsically restricting the proliferation of amplifying germ cells. bgcn function is not required for the proper expression of bam protein.

(Gonczy et al., 1997)

Germ cells accumulating in bam or bgcn mutants testis most resemble amplifying germ cells, because they undergo incomplete cytokinesis and progress through the cell cycle in synchrony within a cyst.

(Gonczy et al., 1997)

Mutants display germline hyperplastic phenotype.

(Mechler, 1994)

The bgcn locus affects early oogenesis: mutations cause the production of few, defective germ cells.

(Schupbach and Wieschaus, 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: bgcn CG10331

(McKearin, 2000.8.3, FlyBase, 1996-)

Source for merge of: bgcn PNBP

(Millburn, 2000.10.11)

Additional comments

Source for merge of bgcn CG10331 was sequence comparison ( date:000815 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

BGCN

(Linsalata et al., 2019, Lesch and Page, 2012, Fuller and Spradling, 2007)

Bgcn

(Cabrita and Martinho, 2023, Connacher and Goldstrohm, 2021, Finger et al., 2021, Vidaurre and Chen, 2021, Blatt et al., 2020, Malik et al., 2020, Rust et al., 2020, Malik et al., 2019, Malik et al., 2017, Moschall et al., 2017, Fu et al., 2015, Chen et al., 2013, Li et al., 2013, Lim et al., 2012, Siddiqui et al., 2012, Kim et al., 2010, Li et al., 2009, Maines et al., 2008, Flores et al., 2007)

CG10330

(McKearin, 2000.8.3)

CG10331

(Dimova et al., 2003, McKearin, 2000.8.3)

CG30170

(National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Vibranovski et al., 2009)

PNBP

(Lukacsovich et al., 1999)

b(2)cgn

(Mechler, 1990)

b(2)gcn

(Gateff et al., 1996, Gateff et al., 1996, Gateff, 1994, Mechler, 1994, Watson et al., 1994, Loffler et al., 1990, Gateff and Mechler, 1989)

bcgn

(Wakimoto et al., 2004)

ben(2)gcn

bgcn

(Arnce et al., 2025, Harris et al., 2025, Kagemann et al., 2025, Hughes et al., 2024, Pang et al., 2023, Voutyraki et al., 2023, Berry et al., 2022, Szarka-Kovács et al., 2022, Tarikere et al., 2022, Varga et al., 2022, Zinshteyn and Barbash, 2022, Malik et al., 2021, Rastegari et al., 2020, Shi et al., 2020, Nelson et al., 2019, Story et al., 2019, Tiwari et al., 2019, Zirin et al., 2019, Jain et al., 2018, McCarthy et al., 2018, Torres et al., 2018, Cheng et al., 2017, Misra et al., 2017, Salz et al., 2017, Shan et al., 2017, Lee et al., 2016, Flores et al., 2015, Chen et al., 2014, Ghosh et al., 2014, Pan et al., 2014, Li et al., 2013, Hong et al., 2012, Insco et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Li et al., 2012, Lim et al., 2012, Monk et al., 2012, Tian et al., 2012, Kaczmarczyk and Kopp, 2011, Richter et al., 2011, Tokusumi et al., 2011, Wang et al., 2011, Gan et al., 2010, Janic et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010, Insco et al., 2009, Insco et al., 2009, Li et al., 2009, Shen et al., 2009, Vibranovski et al., 2009, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Jin et al., 2008, Bauer DuMont et al., 2007, Jung et al., 2007, Parma et al., 2007, Sturgill et al., 2007, Mukai et al., 2006, Terry et al., 2006, Xie et al., 2005)

cg10331

(Lasko, 2000)

fs(2)eo-C

fs(2)eo6

fs(2)eoQS2

gcn

pep

(Schupbach and Wieschaus, 1991)

Name Synonyms

Putative nuclear binding protein

(Lukacsovich et al., 1999)

benign gonial

(Kim et al., 2010)

benign gonial cell neoplasia

(Mukai et al., 2006)

benign gonial cell neoplasm

(Hong et al., 2012, Lim et al., 2012, Tian et al., 2012, Eliazer and Buszczak, 2011, Matsui et al., 2011, Gan et al., 2010, Wasbrough et al., 2010, Li et al., 2009, Vibranovski et al., 2009, Bauer DuMont et al., 2007, Flores et al., 2007, Fuller and Spradling, 2007, Jung et al., 2007, Parma et al., 2007, Terry et al., 2006)

benign-(2)-gonial-cell-neoplasm

cell neoplasm

(Kim et al., 2010)

gonial-cell-neoplasm

peppercorn

Secondary FlyBase IDs

FBgn0000965
FBgn0001096
FBgn0003066
FBgn0026784
FBgn0034917
FBgn0050170

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 100 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47873

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W1I2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W1I2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W1I2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004581

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47873/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004581

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004581

FlyMine - An integrated database for Drosophila genomics

FBgn0004581

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30170

MARRVEL_MODEL - MARRVEL (model organism gene)

47873

Linkouts

BioGRID - A database of protein and genetic interactions.

71021

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004581

DroID - A comprehensive database of gene and protein interactions.

FBgn0004581

DRSC - Results frm RNAi screens

FBgn0004581

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bgcn_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004581

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004581

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30170

Flygut - An atlas of the Drosophila adult midgut

FBgn0004581

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

47873

MIST (protein-protein) - An integrated Molecular Interaction Database

47873

References (187)

The following external sites may use different assemblies or annotations than FlyBase.

3.79

Report Sections