FlyBase Gene Report: Dmel\CycC

General Information

Symbol

Dmel\CycC

Species

D. melanogaster

Name

Cyclin C

Annotation Symbol

CG7281

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004597

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation. (UniProt, P25008)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Cln3, DmcycC

Key Links

Genomic Location

Cytogenetic map

88D6-88D6

Sequence location

3R:14,889,004..14,890,205 [-]

Recombination map

3-56

RefSeq locus

NT_033777 REGION:14889004..14890205

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from direct assay

(Leopold and O'Farrell, 1991)

enables protein binding

inferred from physical interaction with UniProtKB:Q7KTX8

(Loncle et al., 2007)

inferred from physical interaction with UniProtKB:Q9VW47

(Loncle et al., 2007)

enables transcription coregulator activity

inferred from mutant phenotype

(Loncle et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000002458

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR043198

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in chaeta development

inferred from mutant phenotype

(Loncle et al., 2007)

involved_in imaginal disc-derived leg segmentation

inferred from mutant phenotype

(Loncle et al., 2007)

involved_in regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Loncle et al., 2007)

involved_in sex comb development

inferred from mutant phenotype

(Loncle et al., 2007)

involved_in snRNA 3'-end processing

inferred from direct assay

(Chen et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000002587

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from electronic annotation with InterPro:IPR043198

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of CKM complex

inferred from direct assay

(Loncle et al., 2007)

part_of mediator complex

inferred from direct assay

(Loncle et al., 2007)

inferred from physical interaction with FLYBASE:kto; FB:FBgn0001324,FLYBASE:skd; FB:FBgn0003415,FLYBASE:Cdk8; FB:FBgn0015618

(Loncle et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of mediator complex

inferred from biological aspect of ancestor with PANTHER:PTN000002587

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CKM COMPLEX

Protein Family (UniProt)

Belongs to the cyclin family. Cyclin C subfamily. (P25008)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CKM COMPLEX -: The CKM complex is a Cdk8 kinase module which reversibly associates with the Mediator complex (MED) and modulates the transcription coregulator activity of MED. (Adapted from FBrf0191850.)

Protein Function (UniProtKB)

(UniProt, P25008)

Summary (Interactive Fly)

regulatory partner of CDK8 - mediator complex component - cofactor for EcR-dependent transcription - links nutrient intake to developmental transitions and fat metabolism - negative regulator of the lipogenic pathway - regulation of Serpent-dependent transcription and innate immunity - involved in small nuclear RNA (snRNA) 3' end processing - recruited to phosphorylate the Notch ICD and coordinate activation with turnover

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CycC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P25008)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CycC-RA

FBtr0083010

NM_057500

1142

267

Additional Transcript Data and Comments

Reported size (kB)

1.2 (northern blot)

(Lahue et al., 1991)

1.25 (northern blot)

(Leopold and O'Farrell, 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CycC-PA

FBpp0082469

31.3

267

6.27

P25008

NP_476848

AAF55109

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

267 (aa); 31 (kD)

(Lahue et al., 1991)

267 (aa)

(Leopold and O'Farrell, 1991)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.

(UniProt, P25008)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P25008

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycC using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CycC_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.05

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

ovary

(Lahue et al., 1991)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Lahue et al., 1991)

embryonic stage 1 -- 15

(Leopold and O'Farrell, 1991)

Additional Descriptive Data

CycC expression correlates with periods of maximal cell division throughout Drosophila development. It is expressed maximally in ovaries and in early embryos and at low levels in larvae, pupae, and adults. Expression is uniform throughout the embryo.

(Lahue et al., 1991)

Maternal CycC transripts are detected in the embryo. They are concentrated in the islands of yolk-free cytoplasm associated with nuclei, and relocate to the cortical region of the syncytial egg upon nuclear migration to the surface. The signal persists through germband extension but no localized accumulation is seen.

(Leopold and O'Farrell, 1991)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of CKM complex

inferred from direct assay

(Loncle et al., 2007)

part_of mediator complex

inferred from direct assay

(Loncle et al., 2007)

inferred from physical interaction with FLYBASE:kto; FB:FBgn0001324,FLYBASE:skd; FB:FBgn0003415,FLYBASE:Cdk8; FB:FBgn0015618

(Loncle et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycC in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CycC

View exonic expression by tissue for Dmel\CycC

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004597

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41801/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004597

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004597

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004597

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7281

Flygut - An atlas of the Drosophila adult midgut

FBgn0004597

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 26 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CycC

Transgenic constructs containing regulatory region of CycC

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3R)CycC^Y5

(Loncle et al., 2007)

Df(3R)Exel6172

(Loncle et al., 2007, Ryder, 2004.4.26)

Df(3R)Exel6275

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)CycC^Y8

(Loncle et al., 2007)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

CycC^GD12193

lethal (with Df(3R)CycC^Y8)

CycC^Y5

lethal - all die before end of pupal stage (with Df(3R)Exel6172)

CycC^Y5

lethal - all die before end of pupal stage | recessive

CycC^Y5

lethal - all die during embryonic stage | germline clone

CycC^Y5

partially lethal - majority die, with Scer\GAL4^pnr-MD237

CycC^GD17120

viable

CycC^GE22979

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^tin.CΔ4

CycC^GD12193

Other Phenotypes

Allele

abnormal developmental rate

CycC^Y5

abnormal flight, with Scer\GAL4^Mef2.PR

CycC^GD17120

decreased body size | embryonic stage | germline clone

CycC^Y5

some die during pupal stage, with Scer\GAL4^pnr-MD237

CycC^GD17120

some die during pupal stage (with Df(3R)Exel6172)

CycC^Y5

some die during pupal stage | recessive

CycC^Y5

visible, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

adult sense organ, with CycC^UAS.cLa

CycC^Y5

adult sense organ, with CycC^Y5

CycC^UAS.cLa

anterior pupal spiracle

CycC^Y5

leg | somatic clone - Minute background

CycC^Y5

mesonotum, with Scer\GAL4^pnr-MD237

mesothoracic bristle | somatic clone

CycC^Y5

prothoracic tarsal segment | somatic clone

CycC^Y5

sex comb, with CycC^UAS.cLa

CycC^Y5

sex comb, with CycC^Y5

CycC^UAS.cLa

sex comb tooth | somatic clone

CycC^Y5

trichogen cell, with Scer\GAL4^pnr-MD237

CycC^GD17120

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (12)

Hsap\CCNC

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Ccnc

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (9)

Mmus\Ccnc

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\ccnc

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (10)

Drer\ccnc

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\cic-1

13 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\CCNC_ANOGA

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (15)

Atha\AT5G48630

13 of 13

Yes

Atha\AT5G48640

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\SSN8

12 of 13

Yes

Scer\CCL1

2 of 13

Scer\CTK2

2 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\srb11

11 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CycC. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CycC^HMS01095

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Ren et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCNC; cyclin C

13 of 14

123838

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CycC - Cdk8

pull down, autoradiography, two hybrid

(Loncle et al., 2007)

CycC - EcR

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

CycC - Eip63E

two hybrid

(Liu and Finley, 2010)

CycC - IntS1

anti tag coimmunoprecipitation, western blot

(Chen et al., 2012)

CycC - IntS9

anti tag coimmunoprecipitation, western blot

(Chen et al., 2012)

CycC - kto

two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, western blot

(Chen et al., 2012, Loncle et al., 2007)

CycC - skd

anti tag coimmunoprecipitation, western blot, pull down, autoradiography, two hybrid

(Chen et al., 2012, Loncle et al., 2007)

CycC - usp

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Xie et al., 2015)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Doa

suppressible

CycC

(Tang et al., 2018)

Tsc1|gig

suppressible

CycC

(Tang et al., 2018)

External Data

Subunit Structure (UniProtKB)

Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.

(UniProt, P25008 )

Linkouts

BioGRID - A database of protein and genetic interactions.

66871

DroID - A comprehensive database of gene and protein interactions.

FBgn0004597

MIST (protein-protein) - An integrated Molecular Interaction Database

41801

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P25008

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-56

Cytogenetic map

88D6-88D6

Sequence location

3R:14,889,004..14,890,205 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88D6-88D6

Limits computationally determined from genome sequence between P{EP}CG33967^EP666 and P{lacW}Hsc70-4^L3929

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

88D-88E

(determined by in situ hybridisation)

(Lahue et al., 1991)

88E-88E

(determined by in situ hybridisation)

(Leopold and O'Farrell, 1991)

Experimentally Determined Recombination Data

Location

3-56

(FlyBase, 2016)

3-54.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

606845

y¹ v¹; P{TH00498.N}attP2

606847

y¹ v¹; P{TH00504.N}attP2

606849

y¹ v¹; P{TH00605.S}attP2

606850

y¹ v¹; P{TH00600.S}attP2

606851

y¹ v¹; P{TH00601.S}attP2

606853

y¹ v¹; P{TH00599.S}attP2

606914

y¹ v¹; P{TH00598.S}attP2

606915

y¹ v¹; P{TH00503.N}attP2

FlyORF

F003051

M{UAS-CycC.ORF.3xHA.GW}ZH-86Fb

VDRC

v27937

w¹¹¹⁸; P{GD12193}v27937

v48835

w¹¹¹⁸; P{GD17120}v48835/TM3

v342109

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01585}attP40/CyO-GFP

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD35705

Other clones

DPiM_LD35705

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004597

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004597

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Li et al., 2024)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Marr et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

CycC protein is a nuclear protein present in a multiprotein complex. CycC protein interacts in vivo with Cdk8 protein.

(Leclerc et al., 1996)

Overexpression in the eye-antenna imaginal disc has no effect on the morphology of eyes of the resulting adults.

(Richardson et al., 1995)

CycC is a single copy gene. CycC expression in yeast cells lacking cyclin expression can rescue the mutant phenotype.

(Lahue et al., 1991)

Cross-species complementation tests reveal that a CycC cDNA clone will rescue S.cerevisiae deficient in cyclin gene functions.

(Leopold and O'Farrell, 1991)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: CycC CG7281

(Zheng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CCNC

(Manes et al., 2017)

CG1C_DROME

(Storm and Sonnhammer, 2003)

CG7281

(Dahlberg et al., 2015, Hosono et al., 2015, Ni et al., 2010.12.1, Boube et al., 2000)

CYCC

(Joyce et al., 2012, Kondo and Perrimon, 2011, Swaminathan et al., 2010)

Cln3

(Tuxworth and Tear, 2007, Edgar and Orr-Weaver, 2001, Lahue et al., 1991)

Cyc-C

(Leopold et al., 1996)

Cyclin C

(Marr et al., 2014)

DmcycC

(Zraly et al., 2004, Richardson et al., 1995)

SRB11

(Boube et al., 2000)

cycC

(Kuang et al., 2020, Xie et al., 2015, Wang et al., 2012, Carrera et al., 2008, Boube et al., 2000, Foe et al., 1993)

cyclinC

(Li and White, 2003)

dCycC

(Morris et al., 2008)

dTRAP33

(Boube et al., 2000)

Name Synonyms

Cyclin C

(Vilmos et al., 2013, Felix et al., 2012, Swaminathan et al., 2010, Garcia et al., 2007)

cyclin C

(Chen et al., 2012, Tadros et al., 2007, Kim and Lis, 2005, Peng et al., 1998, Secombe et al., 1998)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41801

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P25008

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P25008

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P25008

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004597

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41801/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004597

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004597

FlyMine - An integrated database for Drosophila genomics

FBgn0004597

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7281

MARRVEL_MODEL - MARRVEL (model organism gene)

41801

Linkouts

BioGRID - A database of protein and genetic interactions.

66871

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004597

DroID - A comprehensive database of gene and protein interactions.

FBgn0004597

DRSC - Results frm RNAi screens

FBgn0004597

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CycC_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004597

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004597

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7281

Flygut - An atlas of the Drosophila adult midgut

FBgn0004597

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004597

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034617

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

41801

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P25008

References (99)

The following external sites may use different assemblies or annotations than FlyBase.

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