FB2025_05 , released December 11, 2025
Gene: Dmel\Plc21C
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General Information
Symbol
Dmel\Plc21C
Species
D. melanogaster
Name
Phospholipase C at 21C
Annotation Symbol
CG4574
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004611
Gene Model Status
Current
Stock Availability
64 publicly available
Enzyme Name (EC)
phosphoinositide phospholipase C (3.1.4.11)
Gene Summary
Phospholipase C at 21C (Plc21C) encodes a phospholipase C beta involved in olfaction and flight. It functions downstream of G-protein-coupled receptors coupled to Gq. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
All Summaries
Also Known As

PLC, plc21, plc-21

Key Links
Genomic Location
Cytogenetic map
21B8-21C1
Sequence location
Recombination map
2-0.7
RefSeq locus
NT_033779 REGION:305935..355566
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR016280
(InterPro Project Members, 2004-)
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity
inferred from biological aspect of ancestor with PANTHER:PTN007434641
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001711, InterPro:IPR016280
(InterPro Project Members, 2004-)
enables phosphoric diester hydrolase activity
inferred from electronic annotation with InterPro:IPR017946
(InterPro Project Members, 2004-)
Biological Process (12 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in entrainment of circadian clock by photoperiod
inferred from genetic interaction with FLYBASE:Rh7; FB:FBgn0036260
(Ni et al., 2017)
involved_in flight behavior
inferred from genetic interaction with FLYBASE:Gαq; FB:FBgn0004435,FLYBASE:Itpr; FB:FBgn0010051
(Banerjee et al., 2006)
involved_in neuron cellular homeostasis
inferred from genetic interaction with FLYBASE:GluRIIC; FB:FBgn0046113
(Brusich et al., 2015)
involved_in positive regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Ando et al., 2024)
involved_in regulation of neuromuscular synaptic transmission
inferred from genetic interaction with FLYBASE:GluRIIC; FB:FBgn0046113
(Brusich et al., 2015)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
involved_in G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000818494
(GO Reference Genome Project, 2011-)
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR001192, InterPro:IPR001711
(InterPro Project Members, 2004-)
involved_in lipid metabolic process
inferred from electronic annotation with InterPro:IPR001711, InterPro:IPR017946
(InterPro Project Members, 2004-)
involved_in phosphatidylinositol metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN002569825
(GO Reference Genome Project, 2011-)
involved_in phosphatidylinositol-mediated signaling
inferred from biological aspect of ancestor with PANTHER:PTN000036885
(GO Reference Genome Project, 2011-)
involved_in release of sequestered calcium ion into cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000036885
(GO Reference Genome Project, 2011-)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR001711
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000818494
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
phosphatidylinositol-4,5-bisphosphate phospholipase C activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) (3.1.4.11)
RHEA 33179:
Summaries
Gene Snapshot
Phospholipase C at 21C (Plc21C) encodes a phospholipase C beta involved in olfaction and flight. It functions downstream of G-protein-coupled receptors coupled to Gq. [Date last reviewed: 2018-09-06]
Pathway (FlyBase)
POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
Gene Group (FlyBase)
PHOSPHOLIPASES C -
Phospholipases C are hydrolases that catalyze the conversion of a phospholipid into 1,2-diacylglycerol and a phosphatidate.
Protein Function (UniProtKB)
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
(UniProt, P25455)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Plc21C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P25455)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.44

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Plc21C-RA
FBtr0078047
NM_057504
5486
1312
Plc21C-RB
FBtr0078048
NM_057503
5723
1312
Plc21C-RC
FBtr0078049
NM_205884
7347
1311
Plc21C-RD
FBtr0078050
NM_205883
7127
1318
Plc21C-RG
FBtr0330673
NM_001272889
5300
1250
Plc21C-RH
FBtr0330674
NM_205882
5419
1306
Additional Transcript Data and Comments
Reported size (kB)

7.0, 5.6, 2.8, 1.6 (northern blot); 5.599, 5.421 (longest cDNA)

(Shortridge et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Plc21C-PA
FBpp0077710
145.7
1312
7.32
NP_476852
AAN10493
Plc21C-PB
FBpp0077711
145.7
1312
7.32
NP_476851
AAF51507
Plc21C-PC
FBpp0089225
145.7
1311
7.32
NP_995606
AAS64633
Plc21C-PD
FBpp0089226
146.4
1318
7.33
P25455
NP_995605
AAS64631
Plc21C-PG
FBpp0303523
138.8
1250
7.57
NP_001259818
AGB92355
Plc21C-PH
FBpp0303524
145.0
1306
7.32
NP_995604
AAS64632
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1312 aa isoforms: Plc21C-PA, Plc21C-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

1312, 1305 (aa)

(Shortridge et al., 1991)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Plc21C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.07

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Shortridge et al., 1991)
adult stage
head
(Shortridge et al., 1991)
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval brain
(Shortridge et al., 1991)
adult stage
adult brain
(Shortridge et al., 1991)
adult ventral nerve cord
(Shortridge et al., 1991)
adult optic lobe
(Shortridge et al., 1991)
adult stage | female
oocyte
(Shortridge et al., 1991)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Plc21C in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Plc21C
Transgenic constructs containing regulatory region of Plc21C
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2L)Pi3K21B-A
(Weinkove et al., 1999)
Gene partially disrupted in
Df(2L)Pi3K21B-A
(Weinkove et al., 1999)
T(2;3)Pγ7
(Aravamudan and Broadie, 2003)
Inferred from location ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal circadian rhythm, with Scer\GAL4P0.5.Pdf
abnormal developmental rate | larval stage, with Scer\GAL4phtm.PO
abnormal neurophysiology, with Scer\GAL4Gαq.PS
abnormal neurophysiology, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal neurophysiology (with Plc21CA)
abnormal neurophysiology (with Plc21Ck31911)
abnormal neurophysiology | dominant
abnormal neurophysiology | larval stage | male limited, with Scer\GAL4elav-C155
abnormal neurophysiology | recessive
abnormal smell perception (with Df(2L)Pi3K21B-A)
abnormal smell perception | recessive
photoperiod response variant | adult stage
some die during larval stage, with Scer\GAL4phtm.PO
Phenotype manifest in
Allele
adult midgut region R3, with Scer\GAL4mex1.2.1
adult olfactory receptor neuron Or59b, with Scer\GAL4Orco.2.642.Hsim\VP22
embryonic/larval neuromuscular junction | larval stage | male limited, with Scer\GAL4elav-C155
lipid droplet | adult stage, with Scer\GAL4mex1.2.1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
Hsap\PLCB1
14 of 14
Yes
Yes
Hsap\PLCB3
13 of 14
No
Yes
Hsap\PLCB2
12 of 14
No
Yes
Hsap\PLCB4
5 of 14
No
No
Hsap\PLCD1
5 of 14
No
Yes
Hsap\PLCD3
5 of 14
No
Yes
Hsap\PLCD4
5 of 14
No
Yes
Hsap\PLCZ1
5 of 14
No
Yes
Hsap\PLCG1
4 of 14
No
No
8  
Hsap\PLCG2
4 of 14
No
No
2  
Hsap\PLCH1
4 of 14
No
Yes
Hsap\PLCH2
4 of 14
No
No
Hsap\PLCL1
4 of 14
No
No
Hsap\PLCL2
4 of 14
No
No
Hsap\PLCE1
3 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Plcb1
14 of 14
Yes
Yes
Rnor\Plcb3
13 of 14
No
Yes
Rnor\Plcb2
11 of 14
No
Yes
Rnor\Plcb4
5 of 14
No
No
Rnor\Plcd1
5 of 14
No
Yes
Rnor\Plcd3
5 of 14
No
Yes
Rnor\Plcz1
5 of 14
No
Yes
Rnor\Plcd4
4 of 14
No
Yes
Rnor\Plce1
4 of 14
No
Yes
Rnor\Plch1
4 of 14
No
Yes
Rnor\Plcl2
4 of 14
No
No
Rnor\Plcg1
3 of 14
No
No
Rnor\Plcg2
3 of 14
No
No
Rnor\Plch2
3 of 14
No
No
Rnor\Plcl1
3 of 14
No
No
Mus musculus (laboratory mouse) (15)
Mmus\Plcb1
14 of 14
Yes
Yes
Mmus\Plcb3
13 of 14
No
Yes
Mmus\Plcb2
12 of 14
No
Yes
Mmus\Plcb4
5 of 14
No
No
Mmus\Plcd1
5 of 14
No
Yes
Mmus\Plcd3
5 of 14
No
Yes
Mmus\Plcz1
5 of 14
No
Yes
Mmus\Plcd4
4 of 14
No
Yes
Mmus\Plce1
4 of 14
No
Yes
Mmus\Plcg1
4 of 14
No
No
Mmus\Plcg2
4 of 14
No
No
Mmus\Plch1
4 of 14
No
Yes
Mmus\Plch2
4 of 14
No
No
Mmus\Plcl1
4 of 14
No
No
Mmus\Plcl2
4 of 14
No
No
Xenopus tropicalis (Western clawed frog) (24)
Xtro\plcb3
7 of 13
Yes
Yes
Xtro\plcb1
6 of 13
No
Yes
Xtro\plcb2
6 of 13
No
Yes
Xtro\LOC100488276
2 of 13
No
No
Xtro\plcb4
2 of 13
No
No
Xtro\plcd1
2 of 13
No
Yes
Xtro\plcd3
2 of 13
No
Yes
Xtro\plcd4
2 of 13
No
Yes
Xtro\plch1
2 of 13
No
Yes
Xtro\plcl1
2 of 13
No
No
Xtro\bri3bp
1 of 13
No
Yes
Xtro\kazald1
1 of 13
No
Yes
Xtro\LOC100488897
1 of 13
No
Yes
Xtro\LOC100496658
1 of 13
No
No
Xtro\plce1
1 of 13
No
Yes
Xtro\plcg1
1 of 13
No
No
Xtro\plcg2
1 of 13
No
No
Xtro\plch2
1 of 13
No
No
Xtro\plcl2
1 of 13
No
No
Xtro\pou2f1
1 of 13
No
No
Xtro\slc8a1
1 of 13
No
No
Xtro\taf15
1 of 13
No
No
Xtro\tekt4
1 of 13
No
No
Xtro\tmem60
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\plcb3
13 of 14
Yes
Yes
Drer\plcd1b
5 of 14
No
Yes
Drer\plcd3a
5 of 14
No
Yes
Drer\plcd3b
5 of 14
No
Yes
Drer\plch2b
5 of 14
No
Yes
Drer\plcl1
5 of 14
No
Yes
Drer\LOC100537538
4 of 14
No
No
Drer\plcb2
4 of 14
No
Yes
Drer\plcd1a
4 of 14
No
Yes
Drer\plcd4a
4 of 14
No
Yes
Drer\plcd4b
4 of 14
No
Yes
Drer\plch1
4 of 14
No
Yes
Drer\plch2a
4 of 14
No
No
Drer\plcl5
4 of 14
No
No
Drer\plce1
3 of 14
No
Yes
Drer\plcg1
3 of 14
No
No
Drer\plcg2
2 of 14
No
Yes
Drer\plcl2
2 of 14
No
No
Drer\si:ch211-260p9.3
2 of 14
No
No
Drer\LOC100149080
1 of 14
No
Yes
Drer\plcb1
1 of 14
No
Yes
Drer\plcb4
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\egl-8
4 of 14
Yes
No
Cele\plc-2
4 of 14
Yes
No
Cele\plc-4
4 of 14
Yes
Yes
Cele\plc-3
3 of 14
No
No
Cele\plc-1
2 of 14
No
Yes
Cele\pll-1
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP009115
12 of 12
Yes
Yes
Agam\AgaP_AGAP001936
3 of 12
No
No
Agam\AgaP_AGAP002529
3 of 12
No
Yes
Agam\AgaP_AGAP011152
3 of 12
No
No
Agam\AgaP_AGAP011151
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\AT2G40116
8 of 13
Yes
Yes
Atha\AT3G55940
8 of 13
Yes
No
Atha\PLC1
8 of 13
Yes
Yes
Atha\PLC1
8 of 13
Yes
Yes
Atha\PLC2
8 of 13
Yes
No
Atha\PLC4
8 of 13
Yes
Yes
Atha\PLC5
8 of 13
Yes
Yes
Atha\PLC8
8 of 13
Yes
Yes
Atha\PLC9
8 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PLC1
6 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\plc1
5 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Plc21C. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
norpA
9 of 13
sl
7 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Evidence
    References
    Plc21CHMS00600
    model of  obesity
    CEA
    (Baumbach et al., 2014)
    Plc21CGD11359
    model of  obesity
    CEA
    (Baumbach et al., 2014)
    Potential Models Based on Orthology ( 5 )
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PLCB1; phospholipase C beta 1
    14 of 14
    607120
    PLCB3; phospholipase C beta 3
    13 of 14
    600230
    PLCB2; phospholipase C beta 2
    12 of 14
    604114
        PLCB4; phospholipase C beta 4
        5 of 14
        600810
          PLCD1; phospholipase C delta 1
          5 of 14
          602142
          PLCD3; phospholipase C delta 3
          5 of 14
          608795
              PLCD4; phospholipase C delta 4
              5 of 14
              605939
                  PLCZ1; phospholipase C zeta 1
                  5 of 14
                  608075
                  PLCG1; phospholipase C gamma 1
                  4 of 14
                  172420
                     
                    PLCG2; phospholipase C gamma 2
                    4 of 14
                    600220
                     
                    PLCH1; phospholipase C eta 1
                    4 of 14
                    612835
                      PLCH2; phospholipase C eta 2
                      4 of 14
                      612836
                          PLCL1; phospholipase C like 1 (inactive)
                          4 of 14
                          600597
                              PLCL2; phospholipase C like 2
                              4 of 14
                              614276
                                  PLCE1; phospholipase C epsilon 1
                                  3 of 14
                                  608414
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Interaction Browsers
                                  Summary of Genetic Interactions
                                  Interaction Browsers
                                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                                  Please look at the allele data for full details of the genetic interactions
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  Plc21C
                                  enhanceable
                                  Gαq
                                  (Kain et al., 2008)
                                  Plc21C|Itpr|Gαq
                                  suppressible
                                  SERCA
                                  (Banerjee et al., 2006)
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  cac
                                  enhanceable
                                  Plc21C
                                  (Brusich et al., 2018)
                                  cac
                                  suppressible
                                  Plc21C
                                  (Brusich et al., 2018)
                                  Gαo
                                  suppressible
                                  Plc21C
                                  (Dahdal et al., 2010)
                                  Gαq
                                  enhanceable
                                  Plc21C
                                  (Kain et al., 2008)
                                  Itpr|Gαq
                                  enhanceable
                                  Plc21C
                                  (Banerjee et al., 2006)
                                  norpA
                                  enhanceable
                                  Plc21C
                                  (Shieh et al., 2023)
                                  Pld
                                  suppressible
                                  Plc21C
                                  (Medina-Yáñez et al., 2020)
                                  External Data
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  DroID - A comprehensive database of gene and protein interactions.
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  FlyBase
                                  External Links
                                  FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                  KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                  External Data
                                  Class of Gene
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  2L
                                  Recombination map
                                  2-0.7
                                  Cytogenetic map
                                  21B8-21C1
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  21B8-21C1
                                  Limits computationally determined from genome sequence between P{lacW}U2af38k14504 and P{lacW}RpI135k16513&P{lacW}ebik16213
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  21C1-21C1
                                  (determined by in situ hybridisation)
                                  (Shortridge et al., 1991)
                                  Experimentally Determined Recombination Data
                                  Location

                                  2-0.7

                                  (FlyBase, 2016)

                                  2-0.0

                                  (Comeron et al., 2012)
                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (64)
                                  Genomic Clones (33)
                                  cDNA Clones (17)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                  Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    DRSC - Results frm RNAi screens
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     
                                    Commercially Available Antibodies
                                     
                                    Cell Line Information
                                    Publicly Available Cell Lines
                                     
                                      Other Stable Cell Lines
                                       
                                        Other Comments

                                        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                        (Kiger et al., 2003)

                                        There is preliminary evidence that retinoid (vitamin A) deprivation reduces Plc21C protein levels.

                                        (Picking et al., 1996)

                                        Isolated from a genomic library under reduced stringency conditions using a Drosophila norpA cDNA as a probe.

                                        (Shortridge et al., 1991)

                                        Plc21C has been cloned and sequenced, and its expression pattern has been analysed.

                                        (Shortridge et al., 1991)
                                        Relationship to Other Genes
                                        Source for database merge of
                                        Additional comments

                                        l(2)21Ca null alleles complement the lethality of Plc21C nulls and complement alleles of mbm (contra FBrf0075905 and FBrf0064301).

                                        (Heisenberg, 1995.5.3)
                                        Nomenclature History
                                        Source for database identify of

                                        Source for identity of: Plc21C CG4574

                                        (Guan, 1999.11)
                                        Nomenclature comments
                                        Etymology
                                        Synonyms and Secondary IDs (20)
                                        Reported As
                                        Symbol Synonym
                                        CG4574
                                        (National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Cockcroft and Raghu, 2016, Hosono et al., 2015, Christis and Munro, 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2009, Ni et al., 2008, Mount, 2001.8.14)
                                        PLC
                                        (Blaum et al., 2025, Jeong, 2024, Nolan et al., 2024, Lehmann, 2021, Yadav et al., 2016, Tsuzuki et al., 2014, Brubaker-Purkey and Woodruff, 2013, Roderick and Bootman, 2003, Voets and Nilius, 2003, Tsunoda et al., 1998, Picking et al., 1996)
                                        PLC-21
                                        (Aravamudan and Broadie, 2003)
                                        PLC-21C
                                        (Joshi et al., 2005)
                                        PLC21C
                                        (De and Chatterjee, 2021, Schlichting, 2020, Cockcroft and Raghu, 2016, Girard et al., 2006)
                                        PLC21c
                                        (Ni et al., 2009)
                                        PLCΒ
                                        (Li et al., 1999)
                                        Plc21
                                        (Palomera-Sanchez et al., 2010)
                                        Plc21C
                                        (Akai et al., 2025, Stevens et al., 2023, Lu et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Girard et al., 2021, Heier et al., 2021, Kumar et al., 2021, O'Connor et al., 2021, Uçkun et al., 2021, Yeates and Frank, 2021, Li et al., 2020, Ogueta et al., 2020, Takai et al., 2020, Brodskiy et al., 2019, James et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Michalak et al., 2019, Scopelliti et al., 2019, Al-Ramahi et al., 2018, Gene Disruption Project members, 2018-, Musselman and Kühnlein, 2018, Ogueta et al., 2018, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Kockel et al., 2016, Ou et al., 2016, Balakrishnan et al., 2015, Brusich et al., 2015, Yamanaka et al., 2015, Ashwal-Fluss et al., 2014, Milakovic et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Dahdal et al., 2010, Kain et al., 2009, Adryan et al., 2007, Banerjee et al., 2006, Choksi et al., 2006, Wang et al., 2004)
                                        Plc21c
                                        (Vonolfen et al., 2024, Hu and Wolfner, 2020.6.27)
                                        Plcβ21C
                                        (Banerjee et al., 2006)
                                        plc-21
                                        (Medina-Yáñez et al., 2020, Shortridge et al., 1991)
                                        plc21
                                        (Albert et al., 1997, Albert et al., 1997, Albert et al., 1995, Kim et al., 1995, Albert et al., 1993)
                                        plc21C
                                        (Montell, 2021, Breda et al., 2020, Hu et al., 2020, Li et al., 2020, Ni et al., 2017, Kain et al., 2008)
                                        plc21c
                                        (Cavieres-Lepe and Ewer, 2021, Sokabe et al., 2016, Badsha et al., 2012, Kain et al., 2010)
                                        plcβ21c
                                        (Kain et al., 2008)
                                        Name Synonyms
                                        Phospholipase C 21C
                                        (Dahdal et al., 2010)
                                        Phospholipase C at 21C
                                        (Xun et al., 2008)
                                        phospholipase C
                                        (Tsuzuki et al., 2014)
                                        phospholipase c at 21c
                                        (Ramond et al., 2020)
                                        Secondary FlyBase IDs
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          Study result (0)
                                          Result
                                          Result Type
                                          Title
                                          External Crossreferences and Linkouts ( 85 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                          Other crossreferences
                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                          FlyMine - An integrated database for Drosophila genomics
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                          Linkouts
                                          BioGRID - A database of protein and genetic interactions.
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          Flygut - An atlas of the Drosophila adult midgut
                                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                          References (153)