FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Rap1
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General Information
Symbol
Dmel\Rap1
Species
D. melanogaster
Name
Rap1 GTPase
Annotation Symbol
CG1956
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004636
Gene Model Status
Current
Stock Availability
27 publicly available
Gene Summary
Rap1 GTPase (Rap1) encodes a small GTPase in the Ras superfamily. When GTP-bound, it binds to a number of different effectors, one of which is the product of cno. Together they regulate many morphogenetic movements, including mesoderm invagination and dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

R, Roughened, Dras3, Rap, D-Rap1

Key Links
Genomic Location
Cytogenetic map
62B7-62B7
Sequence location
Recombination map
3-1.0
RefSeq locus
NT_037436 REGION:1859115..1862239
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (30 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables GTPase activity
inferred from direct assay
(Chen et al., 1997)
enables protein binding
inferred from physical interaction with FLYBASE:cno; FB:FBgn0259212,FLYBASE:PDZ-GEF; FB:FBgn0265778
(Boettner and Van Aelst, 2007)
inferred from physical interaction with FLYBASE:Rgl; FB:FBgn0026376
(Mirey et al., 2003)
enables protein kinase binding
inferred from direct assay
(Chang et al., 2018)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225, InterPro:IPR020849
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR038851
(InterPro Project Members, 2004-)
Biological Process (21 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
involved_in adherens junction assembly
inferred from genetic interaction with FLYBASE:PDZ-GEF; FB:FBgn0265778
(Wang et al., 2006)
involved_in border follicle cell migration
inferred from mutant phenotype
(Chang et al., 2018)
involved_in dorsal closure
inferred from genetic interaction with FLYBASE:PDZ-GEF; FB:FBgn0265778
(Boettner and Van Aelst, 2007)
inferred from mutant phenotype
(Boettner et al., 2003)
involved_in germ-line stem cell population maintenance
inferred from genetic interaction with FLYBASE:PDZ-GEF; FB:FBgn0265778
(Wang et al., 2006)
involved_in hemocyte migration
inferred from mutant phenotype
(Siekhaus et al., 2010, Huelsmann et al., 2006)
involved_in imaginal disc-derived wing hair organization
inferred from mutant phenotype
(O'Keefe et al., 2009)
involved_in negative regulation of hippo signaling
inferred from direct assay
(Chang et al., 2018)
involved_in ommatidial rotation
inferred from mutant phenotype
(O'Keefe et al., 2009)
involved_in positive regulation of cell-cell adhesion
inferred from mutant phenotype
(Siekhaus et al., 2010, O'Keefe et al., 2009)
involved_in positive regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Mishra et al., 2005)
involved_in positive regulation of sevenless signaling pathway
inferred from genetic interaction with FLYBASE:cnk; FB:FBgn0286070
(Baril et al., 2014)
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Mavromatakis and Tomlinson, 2012)
involved_in positive regulation of smoothened signaling pathway
inferred from direct assay
(Marada et al., 2016)
inferred from genetic interaction with FLYBASE:smo; FB:FBgn0003444
(Marada et al., 2016)
involved_in R7 cell fate commitment
inferred from mutant phenotype
(Baril et al., 2014, Mavromatakis and Tomlinson, 2012)
involved_in Rap protein signal transduction
inferred from genetic interaction with FLYBASE:Epac; FB:FBgn0085421
(Dupuy et al., 2005)
inferred from direct assay
(Chen et al., 1997)
involved_in regulation of embryonic cell shape
inferred from mutant phenotype
(Huelsmann et al., 2006)
involved_in substrate-dependent cell migration, cell extension
inferred from mutant phenotype
(Huelsmann et al., 2006)
involved_in torso signaling pathway
inferred from mutant phenotype
(Mishra et al., 2005)
NOT involved_in regulation of JNK cascade
inferred from mutant phenotype
(Boettner et al., 2003)
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Boettner et al., 2003)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cellular response to cAMP
inferred from biological aspect of ancestor with PANTHER:PTN001177737
(GO Reference Genome Project, 2011-)
involved_in negative regulation of synaptic vesicle exocytosis
inferred from biological aspect of ancestor with PANTHER:PTN001177737
(GO Reference Genome Project, 2011-)
involved_in Rap protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001177737
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR038851
(InterPro Project Members, 2004-)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR020849
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cell leading edge
inferred from direct assay
(Siekhaus et al., 2010)
located_in cytosol
inferred from direct assay
(Marada et al., 2016)
located_in nucleus
inferred from direct assay
(Marada et al., 2016)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR020849
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000631348
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Ras family. (P08645)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rap1 GTPase (Rap1) encodes a small GTPase in the Ras superfamily. When GTP-bound, it binds to a number of different effectors, one of which is the product of cno. Together they regulate many morphogenetic movements, including mesoderm invagination and dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
RAS GTPASES -
The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).
Pathway (FlyBase)
NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
TORSO SIGNALING PATHWAY CORE COMPONENTS -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
POSITIVE REGULATORS OF SEVENLESS SIGNALING PATHWAY -
Positive regulators of Sevenless signaling up-regulate the pathway, promoting cell fate to that of an R7 photoreceptor. (Adapted from FBrf0127283 and FBrf0221727).
POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -
Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
Protein Function (UniProtKB)
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in photoreceptor cell determination.
(UniProt, P08645)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
R: Roughened
Eyes of R/+ rough, have some large dark facets. Photoreceptor cell 7 frequently absent (Carthew). Male genitalia frequently rotated and male sometimes sterile; viability about 80% wild type. Homozygote semilethal; wings spread. Thorax short; acrostichal hairs deranged, some missing; eyes small. Homozygous female fertile. RK1.
*R51b
Eyes of heterozygote small, oblong, and rough; facets and eye hairs irregular. Viability good. Homozygote lethal. R51b/R has very small eyes, much fusion of facets, and resembles gl and Gl. RK1.
Summary (Interactive Fly)

Ras-like GTPase - establishes of cell polarity by regulation of columnar cell shape - controls epithelial invagination via α-Catenin - regulates cell morphology within the developing wing epithelium - regulates radial movement of mesodermal cells during monolayer formation - regulates adhesive contacts necessary for maintenance of Egfr signaling between cells and differentiation of wing veins and photoreceptors

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rap1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P08645)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rap1-RA
FBtr0072867
NM_057509
2741
184
Rap1-RB
FBtr0303154
NM_001202094
2872
184
Rap1-RC
FBtr0332671
NM_001274366
2702
184
Additional Transcript Data and Comments
Reported size (kB)

2.9, 1.9, 1.5 (northern blot)

(Kimchie et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rap1-PA
FBpp0072746
20.9
184
6.58
P08645
NP_476857
AAF47583
Rap1-PB
FBpp0292253
20.9
184
6.58
P08645
NP_001189023
ADV37460
Rap1-PC
FBpp0304917
20.9
184
6.58
P08645
NP_001261295
AGB93990
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

184 aa isoforms: Rap1-PA, Rap1-PB, Rap1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

184 (aa)

(Hariharan et al., 1991)
Comments

R+P184

(FlyBase, 1992-)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rap1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.82

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc
(Segal and Shilo, 1986)
genital disc
(Segal and Shilo, 1986)
adult stage
adult brain | restricted
(Segal and Shilo, 1986)
adult ventral nerve cord
(Segal and Shilo, 1986)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Segal and Shilo, 1986)
third instar larval stage
larval brain | restricted
(Segal and Shilo, 1986)
eye-antennal disc
(Segal and Shilo, 1986)
adult stage
adult ventral nerve cord
(Segal and Shilo, 1986)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis
oocyte
(Kimchie et al., 1989)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell leading edge
inferred from direct assay
(Siekhaus et al., 2010)
located_in cytosol
inferred from direct assay
(Marada et al., 2016)
located_in nucleus
inferred from direct assay
(Marada et al., 2016)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rap1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 37 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rap1
Transgenic constructs containing regulatory region of Rap1
Aberrations (Deficiencies and Duplications) ( 151 )
Inferred from experimentation ( 151 )
Gene disrupted in
Df(3L)Aprt-1
(Wang et al., 1994)
Df(3L)Aprt-3
(Wang et al., 1994)
Df(3L)Aprt-9
(Wang et al., 1994)
Df(3L)Aprt-10
(Wang et al., 1994)
Df(3L)Aprt-12
(Wang et al., 1994)
Df(3L)Aprt-13
(Wang et al., 1994)
Df(3L)Aprt-14
(Wang et al., 1994)
Df(3L)Aprt-16
(Wang et al., 1994)
Df(3L)Aprt-19
(Wang et al., 1994)
Df(3L)Aprt-24
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-26
(Wang et al., 1994)
Df(3L)Aprt-27
(Wang et al., 1994)
Df(3L)Aprt-29
(Wang et al., 1994)
Df(3L)Aprt-31
(Wang et al., 1994)
Df(3L)Aprt-32
(Wang et al., 1994)
Df(3L)Aprt-36
(Wang et al., 1994)
Df(3L)Aprt-42
(Wang et al., 1994)
Df(3L)Aprt-46
(Wang et al., 1994)
Df(3L)Aprt-47
(Wang et al., 1994)
Df(3L)Aprt-53
(Wang et al., 1994)
Df(3L)Aprt-54
(Wang et al., 1994)
Df(3L)Aprt-61
(Wang et al., 1994)
Df(3L)Aprt-65
(Wang et al., 1994)
Df(3L)Aprt-66
(Wang et al., 1994)
Df(3L)Aprt-72
(Wang et al., 1994)
Df(3L)Aprt-73
(Wang et al., 1994)
Df(3L)Aprt-74
(Wang et al., 1994)
Df(3L)Aprt-79
(Wang et al., 1994)
Df(3L)Aprt-87
(Wang et al., 1994)
Df(3L)Aprt-88
(Wang et al., 1994)
Df(3L)Aprt-91
(Wang et al., 1994)
Df(3L)Aprt-92
(Wang et al., 1994)
Df(3L)Aprt-93
(Wang et al., 1994)
Df(3L)Aprt-95
(Wang et al., 1994)
Df(3L)Aprt-98
(Wang et al., 1994)
Df(3L)Aprt-99
(Wang et al., 1994)
Df(3L)Aprt-100
(Wang et al., 1994)
Df(3L)Aprt-102
(Wang et al., 1994)
Df(3L)Aprt-105
(Wang et al., 1994)
Df(3L)Aprt-106
(Wang et al., 1994)
Df(3L)Aprt-107
(Wang et al., 1994)
Df(3L)Aprt-108
(Wang et al., 1994)
Df(3L)Aprt-109
(Wang et al., 1994)
Df(3L)Aprt-110
(Wang et al., 1994)
Df(3L)Aprt-112
(Wang et al., 1994)
Df(3L)Aprt-113
(Wang et al., 1994)
Df(3L)Aprt-114
(Wang et al., 1994)
Df(3L)Aprt-117
(Wang et al., 1994)
Df(3L)Aprt-122
(Wang et al., 1994)
Df(3L)Aprt-124
(Wang et al., 1994)
Df(3L)Aprt-126
(Machado and Andrew, 2000)
Df(3L)Aprt-130
(Wang et al., 1994)
Df(3L)Aprt-131
(Wang et al., 1994)
Df(3L)Aprt-133
(Wang et al., 1994)
Df(3L)Aprt-134
(Wang et al., 1994)
Df(3L)Aprt-137
(Wang et al., 1994)
Df(3L)Aprt-138
(Wang et al., 1994)
Df(3L)Aprt-140
(Wang et al., 1994)
Df(3L)Aprt-142
(Wang et al., 1994)
Df(3L)Aprt-143
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-144
(Wang et al., 1994)
Df(3L)Aprt-148
(Wang et al., 1994)
Df(3L)Aprt-151
(Wang et al., 1994)
Df(3L)Aprt-152
(Wang et al., 1994)
Df(3L)Aprt-153
(Wang et al., 1994)
Df(3L)Aprt-156
(Wang et al., 1994)
Df(3L)Aprt-159
(Wang et al., 1994)
Df(3L)Aprt-161
(Wang et al., 1994)
Df(3L)Aprt-162
(Wang et al., 1994)
Df(3L)Aprt-163
(Wang et al., 1994)
Df(3L)Aprt-164
(Wang et al., 1994)
Df(3L)Aprt-165
(Wang et al., 1994)
Df(3L)Aprt-166
(Wang et al., 1994)
Df(3L)Aprt-167
(Wang et al., 1994)
Df(3L)Aprt-169
(Wang et al., 1994)
Df(3L)Aprt-170
(Wang et al., 1994)
Df(3L)Aprt-172
(Wang et al., 1994)
Df(3L)Aprt-173
(Wang et al., 1994)
Df(3L)Aprt-175
(Wang et al., 1994)
Df(3L)Aprt-176
(Wang et al., 1994)
Df(3L)Aprt-177
(Wang et al., 1994)
Df(3L)Aprt-179
(Wang et al., 1994)
Df(3L)Aprt-181
(Wang et al., 1994)
Df(3L)Aprt-184
(Wang et al., 1994)
Df(3L)Aprt-186
(Wang et al., 1994)
Df(3L)Aprt-189
(Wang et al., 1994)
Df(3L)Aprt-191
(Wang et al., 1994)
Df(3L)Aprt-192
(Wang et al., 1994)
Df(3L)Aprt-193
(Wang et al., 1994)
Df(3L)Aprt-194
(Wang et al., 1994)
Df(3L)Aprt-199
(Wang et al., 1994)
Df(3L)Aprt-201
(Wang et al., 1994)
Df(3L)Exel6088
(Ryder, 2004.4.26)
Df(3L)R-E
(Fischer et al., 1997, Li et al., 1997, Hariharan et al., 1991)
Ts(2Rt;3Rt)Aprt-185
(Wang et al., 1994)
Gene not disrupted in
Df(3L)Aprt-15
(Wang et al., 1994)
Df(3L)Aprt-18
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-21
(Wang et al., 1994)
Df(3L)Aprt-48
(Wang et al., 1994)
Df(3L)Aprt-56
(Wang et al., 1994)
Df(3L)Aprt-57
(Wang et al., 1994)
Df(3L)Aprt-71
(Wang et al., 1994)
Df(3L)Aprt-77
(Wang et al., 1994)
Df(3L)Aprt-84
(Wang et al., 1994)
Df(3L)Aprt-89
(Wang et al., 1994)
Df(3L)Aprt-90
(Wang et al., 1994)
Df(3L)Aprt-94
(Wang et al., 1994)
Df(3L)Aprt-96
(Wang et al., 1994)
Df(3L)Aprt-97
(Wang et al., 1994)
Df(3L)Aprt-101
(Wang et al., 1994)
Df(3L)Aprt-103
(Wang et al., 1994)
Df(3L)Aprt-104
(Wang et al., 1994)
Df(3L)Aprt-111
(Wang et al., 1994)
Df(3L)Aprt-115
(Wang et al., 1994)
Df(3L)Aprt-116
(Wang et al., 1994)
Df(3L)Aprt-118
(Wang et al., 1994)
Df(3L)Aprt-119
(Wang et al., 1994)
Df(3L)Aprt-120
(Wang et al., 1994)
Df(3L)Aprt-121
(Wang et al., 1994)
Df(3L)Aprt-123
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-125
(Wang et al., 1994)
Df(3L)Aprt-126
(Wang et al., 1994)
Df(3L)Aprt-127
(Wang et al., 1994)
Df(3L)Aprt-128
(Wang et al., 1994)
Df(3L)Aprt-129
(Wang et al., 1994)
Df(3L)Aprt-132
(Wang et al., 1994)
Df(3L)Aprt-135
(Wang et al., 1994)
Df(3L)Aprt-136
(Wang et al., 1994)
Df(3L)Aprt-139
(Wang et al., 1994)
Df(3L)Aprt-141
(Wang et al., 1994)
Df(3L)Aprt-145
(Wang et al., 1994)
Df(3L)Aprt-146
(Wang et al., 1994)
Df(3L)Aprt-147
(Wang et al., 1994)
Df(3L)Aprt-149
(Wang et al., 1994)
Df(3L)Aprt-150
(Wang et al., 1994)
Df(3L)Aprt-154
(Wang et al., 1994)
Df(3L)Aprt-157
(Wang et al., 1994)
Df(3L)Aprt-158
(Wang et al., 1994)
Df(3L)Aprt-160
(Wang et al., 1994)
Df(3L)Aprt-168
(Wang et al., 1994)
Df(3L)Aprt-171
(Wang et al., 1994)
Df(3L)Aprt-174
(Wang et al., 1994)
Df(3L)Aprt-178
(Wang et al., 1994)
Df(3L)Aprt-179
(Wang et al., 1994)
Df(3L)Aprt-180
(Wang et al., 1994)
Df(3L)Aprt-182
(Wang et al., 1994)
Df(3L)Aprt-183
(Wang et al., 1994)
Df(3L)Aprt-187
(Wang et al., 1994)
Df(3L)Aprt-188
(Wang et al., 1994)
Df(3L)Aprt-190
(Wang et al., 1994)
Df(3L)Aprt-195
(Wang et al., 1994)
Df(3L)Aprt-196
(Wang et al., 1994)
Df(3L)Aprt-198
(Wang et al., 1994)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4GMR.PF
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage, with Scer\GAL4ptc-559.1
lethal - all die during embryonic stage, with Scer\GAL4sca.PU
lethal - all die during embryonic stage, with Scer\GAL4VP16.PDZ-GEF
lethal - all die during embryonic stage | germline clone | non-rescuable maternal effect
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell migration | embryonic stage, with Scer\GAL4VP16.PDZ-GEF
abnormal cell shape | embryonic stage, with Scer\GAL4srp
abnormal neurophysiology | larval stage, with Scer\GAL4elav-C155
abnormal neurophysiology | larval stage | conditional (with Df(3L)ED4287)
some die during embryonic stage, with Scer\GAL4ptc-559.1
some die during embryonic stage, with Scer\GAL4sca.PU
some die during embryonic stage | non-rescuable maternal effect
some die during larval stage
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | recessive
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4hs.2sev
visible | dominant
visible | recessive
wild-type
Phenotype manifest in
Allele
adherens junction | somatic clone
border follicle cell, with Scer\GAL4slbo.2.6, Scer\GAL4upd1.PU
cone cell | somatic clone
cone cell | somatic clone | increased number, with Scer\GAL4Act5C.PP
ectoderm | embryonic stage, with Scer\GAL4VP16.PDZ-GEF
egg chamber
embryo, with Scer\GAL4VP16.PDZ-GEF
embryo | dorsal closure stage
embryo | dorsal closure stage, with Scer\GAL4c381
embryo | dorsal closure stage, with Scer\GAL4pnr-MD237
embryo | dorsal closure stage, with Scer\GAL4ptc-559.1
embryo | dorsal closure stage | germline clone | maternal effect
embryo | gastrula stage | germline clone | maternal effect
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | anterior
embryonic/first instar larval cuticle | embryonic stage, with Scer\GAL4VP16.PDZ-GEF
embryonic/first instar larval cuticle | ventral
embryonic/larval dorsal vessel | germline clone | maternal effect
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | larval stage (with Df(3L)ED4287)
embryonic/larval plasmatocyte
embryonic/larval plasmatocyte, with Scer\GAL4srp
embryonic head | germline clone | maternal effect
eye
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye photoreceptor cell
follicle cell
follicle cell | somatic clone
germarium
glial cell, with Scer\GAL4repo
hemocyte | embryonic stage
larval ventral nerve cord | germline clone | maternal effect
macropinosome | larval stage, with Scer\GAL4elav-C155
macropinosome | larval stage (with Df(3L)ED4287)
mesoderm | germline clone | maternal effect
NMJ bouton | decreased number | larval stage, with Scer\GAL4elav-C155
NMJ bouton | increased number | larval stage (with Df(3L)ED4287)
nurse cell
ommatidium
ommatidium | somatic clone
ovary
photoreceptor cell R1
photoreceptor cell R1 | somatic clone
photoreceptor cell R2
photoreceptor cell R2 | somatic clone | increased number
photoreceptor cell R3
photoreceptor cell R3 | somatic clone | increased number
photoreceptor cell R4
photoreceptor cell R4 | somatic clone | increased number
photoreceptor cell R5
photoreceptor cell R5 | somatic clone | increased number
photoreceptor cell R6
photoreceptor cell R6 | somatic clone
photoreceptor cell R7
photoreceptor cell R7 | somatic clone
photoreceptor cell R7 | somatic clone, with Scer\GAL4Act5C.PP
photoreceptor cell R7 | somatic clone | increased number, with Scer\GAL4Act5C.PP
photoreceptor cell R8
photoreceptor cell R8 | somatic clone | increased number
photoreceptor neuron | somatic clone
pigment cell | somatic clone
primary pigment cell | somatic clone | increased number, with Scer\GAL4Act5C.PP
primordial germ cell | germline clone | maternal effect
rhabdomere | increased number
secondary pigment cell
secondary pigment cell | somatic clone | increased number, with Scer\GAL4Act5C.PP
slit diaphragm | decreased number | larval stage, with Scer\GAL4sns.GCN
stalk follicle cell
ventral furrow | germline clone | maternal effect
wing | P-stage | somatic clone
wing vein, with Scer\GAL4en.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (71)
Hsap\RAP1A
12 of 14
Yes
Yes
3  
Hsap\RAP1B
11 of 14
No
Yes
 
3  
Hsap\RAP1BL
7 of 14
No
Yes
Hsap\RAP2A
5 of 14
No
No
Hsap\RAP2B
5 of 14
No
No
Hsap\RAP2C
5 of 14
No
No
Hsap\HRAS
4 of 14
No
No
3  
Hsap\KRAS
4 of 14
No
No
2  
Hsap\NRAS
4 of 14
No
No
Hsap\RRAS2
4 of 14
No
No
2  
Hsap\RRAS
3 of 14
No
No
Hsap\DIRAS1
2 of 14
No
No
1  
Hsap\DIRAS2
2 of 14
No
No
1  
Hsap\GEM
2 of 14
No
No
Hsap\MRAS
2 of 14
No
No
Hsap\RALA
2 of 14
No
No
1  
Hsap\RALB
2 of 14
No
No
1  
Hsap\RASD1
2 of 14
No
No
1  
Hsap\RASD2
2 of 14
No
No
Hsap\RASL10A
2 of 14
No
No
Hsap\RASL10B
2 of 14
No
No
1  
Hsap\RASL11A
2 of 14
No
No
1  
Hsap\RASL11B
2 of 14
No
No
1  
Hsap\RASL12
2 of 14
No
No
Hsap\REM1
2 of 14
No
No
Hsap\REM2
2 of 14
No
No
Hsap\RERG
2 of 14
No
No
Hsap\RERGL
2 of 14
No
No
Hsap\RHEB
2 of 14
No
No
1  
Hsap\RHEBL1
2 of 14
No
No
Hsap\RIT1
2 of 14
No
No
1  
Hsap\RIT2
2 of 14
No
No
Hsap\RRAD
2 of 14
No
No
1  
Hsap\CDC42
1 of 14
No
No
0  
Hsap\CPLANE2
1 of 14
No
Yes
Hsap\DIRAS3
1 of 14
No
No
Hsap\ERAS
1 of 14
No
No
Hsap\NKIRAS1
1 of 14
No
No
Hsap\NKIRAS2
1 of 14
No
No
1  
Hsap\RAB1A
1 of 14
No
No
Hsap\RAB1B
1 of 14
No
No
Hsap\RAB1C
1 of 14
No
No
Hsap\RAB2A
1 of 14
No
No
1  
Hsap\RAB2B
1 of 14
No
No
Hsap\RAB3A
1 of 14
No
No
Hsap\RAB5B
1 of 14
No
No
Hsap\RAB6A
1 of 14
No
No
Hsap\RAB6B
1 of 14
No
No
Hsap\RAB7A
1 of 14
No
No
5  
Hsap\RAB7B
1 of 14
No
No
Hsap\RAB8A
1 of 14
No
No
1  
Hsap\RAB8B
1 of 14
No
No
Hsap\RAB9A
1 of 14
No
No
1  
Hsap\RAB9B
1 of 14
No
No
1  
Hsap\RAB12
1 of 14
No
No
Hsap\RAB13
1 of 14
No
No
Hsap\RAB15
1 of 14
No
No
Hsap\RAB17
1 of 14
No
No
Hsap\RAB18
1 of 14
No
No
1  
Hsap\RAB21
1 of 14
No
No
Hsap\RAB23
1 of 14
No
No
1  
Hsap\RAB26
1 of 14
No
No
Hsap\RAB30
1 of 14
No
No
1  
Hsap\RAB33B
1 of 14
No
No
Hsap\RAB35
1 of 14
No
No
Hsap\RAB37
1 of 14
No
No
Hsap\RAB41
1 of 14
No
No
1  
Hsap\RAC1
1 of 14
No
No
8  
Hsap\RHOF
1 of 14
No
No
Hsap\RHOG
1 of 14
No
No
Hsap\RHOH
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (49)
Rnor\Rap1a
12 of 14
Yes
Yes
Rnor\Rap1b
11 of 14
No
Yes
Rnor\Rap2b
5 of 14
No
No
Rnor\Rap2c
5 of 14
No
No
Rnor\Hras
4 of 14
No
No
Rnor\Nras
4 of 14
No
No
Rnor\Rap2a
4 of 14
No
No
Rnor\Rras2
4 of 14
No
No
Rnor\Diras3
3 of 14
No
No
Rnor\Kras
3 of 14
No
No
Rnor\Rras
3 of 14
No
No
Rnor\Diras1
2 of 14
No
No
Rnor\Diras2
2 of 14
No
No
Rnor\Eras
2 of 14
No
No
Rnor\Gem
2 of 14
No
No
Rnor\Mras
2 of 14
No
No
Rnor\Rala
2 of 14
No
No
Rnor\Ralb
2 of 14
No
No
Rnor\Rasd1
2 of 14
No
No
Rnor\Rasd2
2 of 14
No
No
Rnor\Rasl10b
2 of 14
No
No
Rnor\Rasl11a
2 of 14
No
No
Rnor\Rasl11b
2 of 14
No
No
Rnor\Rasl12
2 of 14
No
No
Rnor\Rem1
2 of 14
No
No
Rnor\Rem2
2 of 14
No
No
Rnor\Rergl
2 of 14
No
No
Rnor\Rerg
2 of 14
No
No
Rnor\Rheb
2 of 14
No
No
Rnor\Rit1
2 of 14
No
No
Rnor\Rit2
2 of 14
No
No
Rnor\Rrad
2 of 14
No
No
Rnor\Cdc42
1 of 14
No
No
Rnor\Nkiras1
1 of 14
No
No
Rnor\Nkiras2
1 of 14
No
No
Rnor\Rab3a
1 of 14
No
No
Rnor\Rab5b
1 of 14
No
No
Rnor\Rab6a
1 of 14
No
No
Rnor\Rab7a
1 of 14
No
No
Rnor\Rab7b
1 of 14
No
No
Rnor\Rab9b
1 of 14
No
No
Rnor\Rab12
1 of 14
No
No
Rnor\Rab21
1 of 14
No
No
Rnor\Rab23
1 of 14
No
No
Rnor\Rab30
1 of 14
No
No
Rnor\Rab37
1 of 14
No
No
Rnor\Rab39a
1 of 14
No
No
Rnor\Rasl10a
1 of 14
No
No
Rnor\Rhebl1
1 of 14
No
No
Mus musculus (laboratory mouse) (49)
Mmus\Rap1a
11 of 14
Yes
Yes
Mmus\Rap1b
11 of 14
Yes
Yes
Mmus\Rap2a
5 of 14
No
No
Mmus\Rap2b
5 of 14
No
No
Mmus\Rap2c
5 of 14
No
No
Mmus\Hras
4 of 14
No
No
Mmus\Kras
4 of 14
No
No
Mmus\Nras
4 of 14
No
No
Mmus\Rras2
4 of 14
No
No
Mmus\Gm266
3 of 14
No
No
Mmus\Rras
3 of 14
No
No
Mmus\Diras1
2 of 14
No
No
Mmus\Diras2
2 of 14
No
No
Mmus\Eras
2 of 14
No
No
Mmus\Gem
2 of 14
No
No
Mmus\Mras
2 of 14
No
No
Mmus\Rala
2 of 14
No
No
Mmus\Ralb
2 of 14
No
No
Mmus\Rasd1
2 of 14
No
No
Mmus\Rasd2
2 of 14
No
No
Mmus\Rasl10a
2 of 14
No
No
Mmus\Rasl10b
2 of 14
No
No
Mmus\Rasl11a
2 of 14
No
No
Mmus\Rasl11b
2 of 14
No
No
Mmus\Rasl12
2 of 14
No
No
Mmus\Rem1
2 of 14
No
No
Mmus\Rem2
2 of 14
No
No
Mmus\Rergl
2 of 14
No
No
Mmus\Rerg
2 of 14
No
No
Mmus\Rhebl1
2 of 14
No
No
Mmus\Rheb
2 of 14
No
No
Mmus\Rit1
2 of 14
No
No
Mmus\Rit2
2 of 14
No
No
Mmus\Rrad
2 of 14
No
No
Mmus\Cdc42
1 of 14
No
No
Mmus\Cplane2
1 of 14
No
Yes
Mmus\Nkiras1
1 of 14
No
No
Mmus\Nkiras2
1 of 14
No
No
Mmus\Rab3a
1 of 14
No
No
Mmus\Rab5b
1 of 14
No
No
Mmus\Rab6a
1 of 14
No
No
Mmus\Rab7
1 of 14
No
No
Mmus\Rab9b
1 of 14
No
No
Mmus\Rab12
1 of 14
No
No
Mmus\Rab13
1 of 14
No
No
Mmus\Rab21
1 of 14
No
No
Mmus\Rab23
1 of 14
No
No
Mmus\Rab30
1 of 14
No
No
Mmus\Rab37
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (49)
Xtro\rap1b
9 of 13
Yes
Yes
Xtro\rap1a
7 of 13
No
Yes
Xtro\rap2a
4 of 13
No
No
Xtro\rap2c
4 of 13
No
No
Xtro\rap2b
3 of 13
No
No
Xtro\krasl
2 of 13
No
No
Xtro\kras
2 of 13
No
No
Xtro\rras
2 of 13
No
No
Xtro\cdc42
1 of 13
No
No
Xtro\col11a2
1 of 13
No
No
Xtro\comt.2
1 of 13
No
Yes
Xtro\ctnna1
1 of 13
No
No
Xtro\diras2
1 of 13
No
No
Xtro\diras3
1 of 13
No
No
Xtro\gem
1 of 13
No
No
Xtro\hras
1 of 13
No
No
Xtro\kdelr2
1 of 13
No
No
Xtro\LOC100488596
1 of 13
No
No
Xtro\nras
1 of 13
No
No
Xtro\pofut1
1 of 13
No
No
Xtro\rab1a
1 of 13
No
No
Xtro\rab2b
1 of 13
No
No
Xtro\rab3a
1 of 13
No
No
Xtro\rab3c
1 of 13
No
No
Xtro\rab5b
1 of 13
No
No
Xtro\rab5d
1 of 13
No
No
Xtro\rab6b
1 of 13
No
No
Xtro\rab8b
1 of 13
No
No
Xtro\rab12
1 of 13
No
No
Xtro\rab18
1 of 13
No
No
Xtro\rab24
1 of 13
No
No
Xtro\rab26
1 of 13
No
No
Xtro\rab33a
1 of 13
No
Yes
Xtro\rab35l
1 of 13
No
No
Xtro\rab35
1 of 13
No
No
Xtro\rac1
1 of 13
No
No
Xtro\rac3
1 of 13
No
No
Xtro\rasd1
1 of 13
No
No
Xtro\rasd2
1 of 13
No
No
Xtro\rasl10b
1 of 13
No
No
Xtro\rasl11b
1 of 13
No
No
Xtro\rem2
1 of 13
No
No
Xtro\rergl
1 of 13
No
No
Xtro\rerg
1 of 13
No
No
Xtro\rhebl1
1 of 13
No
No
Xtro\rhoj
1 of 13
No
No
Xtro\rras2
1 of 13
No
No
Xtro\tenm2
1 of 13
No
No
Xtro\wdr37
1 of 13
No
No
Danio rerio (Zebrafish) (65)
Drer\rap1aa
13 of 14
Yes
Yes
Drer\rap1ab
12 of 14
No
Yes
Drer\rap1b
10 of 14
No
Yes
Drer\LOC100332969
5 of 14
No
No
Drer\rap2ab
5 of 14
No
No
Drer\rap2c
5 of 14
No
No
Drer\hrasb
4 of 14
No
No
Drer\kras
4 of 14
No
No
Drer\nras
4 of 14
No
No
Drer\rap2b
4 of 14
No
No
Drer\rras2
4 of 14
No
No
Drer\zgc:55558
4 of 14
No
No
Drer\hrasa
3 of 14
No
No
Drer\rras
3 of 14
No
No
Drer\diras1a
2 of 14
No
No
Drer\gem
2 of 14
No
No
Drer\ralaa
2 of 14
No
No
Drer\ralab
2 of 14
No
No
Drer\ralba
2 of 14
No
No
Drer\rasd1
2 of 14
No
No
Drer\rasd2
2 of 14
No
No
Drer\rasd3
2 of 14
No
No
Drer\rasl10a
2 of 14
No
No
Drer\rasl11a
2 of 14
No
No
Drer\rasl11b
2 of 14
No
No
Drer\rem1
2 of 14
No
No
Drer\rem2
2 of 14
No
No
Drer\rergla
2 of 14
No
No
Drer\rerglb
2 of 14
No
No
Drer\rhebl1
2 of 14
No
No
Drer\rrad
2 of 14
No
No
Drer\si:dkey-27j5.5
2 of 14
No
No
Drer\si:dkeyp-59c12.1
2 of 14
No
No
Drer\zgc:64022
2 of 14
No
No
Drer\zgc:110699
2 of 14
No
No
Drer\zgc:171704
2 of 14
No
No
Drer\cdc42l
1 of 14
No
No
Drer\cplane2
1 of 14
No
Yes
Drer\diras1b
1 of 14
No
No
Drer\mrasa
1 of 14
No
No
Drer\mrasb
1 of 14
No
No
Drer\nkiras1
1 of 14
No
No
Drer\nkiras2
1 of 14
No
No
Drer\rab1aa
1 of 14
No
No
Drer\rab1ba
1 of 14
No
No
Drer\rab1bb
1 of 14
No
No
Drer\rab5b
1 of 14
No
No
Drer\rab6a
1 of 14
No
No
Drer\rab7a
1 of 14
No
No
Drer\rab7b
1 of 14
No
No
Drer\rab13
1 of 14
No
No
Drer\rab15
1 of 14
No
No
Drer\rab18a
1 of 14
No
No
Drer\rab18b
1 of 14
No
No
Drer\rab21
1 of 14
No
No
Drer\rab30
1 of 14
No
No
Drer\ralbb
1 of 14
No
Yes
Drer\rasd4
1 of 14
No
No
Drer\rasl12
1 of 14
No
No
Drer\rerg
1 of 14
No
No
Drer\rheb
1 of 14
No
No
Drer\rhof
1 of 14
No
No
Drer\rit1
1 of 14
No
No
Drer\zgc:100918
1 of 14
No
No
Drer\zgc:171927
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (39)
Cele\rap-1
13 of 14
Yes
Yes
Cele\rap-2
5 of 14
No
No
Cele\let-60
4 of 14
No
No
Cele\rap-3
3 of 14
No
No
Cele\ras-1
3 of 14
No
No
Cele\D1081.4
2 of 14
No
No
Cele\drn-1
2 of 14
No
No
Cele\F20D6.8
2 of 14
No
No
Cele\ras-2
2 of 14
No
No
Cele\rheb-1
2 of 14
No
No
Cele\ssr-2
2 of 14
No
No
Cele\W04C9.5
2 of 14
No
No
Cele\Y52B11A.4
2 of 14
No
No
Cele\Y71F9AR.2
2 of 14
No
No
Cele\C56E6.2
1 of 14
No
No
Cele\cdc-42
1 of 14
No
No
Cele\ced-10
1 of 14
No
No
Cele\D1081.11
1 of 14
No
Yes
Cele\D1081.12
1 of 14
No
Yes
Cele\F11A5.4
1 of 14
No
No
Cele\kbrl-1
1 of 14
No
No
Cele\mig-2
1 of 14
No
No
Cele\rab-1
1 of 14
No
No
Cele\rab-5
1 of 14
No
No
Cele\rab-6.1
1 of 14
No
No
Cele\rab-6.2
1 of 14
No
No
Cele\rab-7
1 of 14
No
No
Cele\rab-8
1 of 14
No
No
Cele\rab-10
1 of 14
No
No
Cele\rab-11.2
1 of 14
No
No
Cele\rab-18
1 of 14
No
No
Cele\rab-21
1 of 14
No
No
Cele\rab-30
1 of 14
No
No
Cele\rab-35
1 of 14
No
No
Cele\rab-39
1 of 14
No
No
Cele\ral-1
1 of 14
No
No
Cele\rsef-1
1 of 14
No
No
Cele\unc-108
1 of 14
No
No
Cele\Y71F9AR.4
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (33)
Agam\AgaP_AGAP001874
11 of 12
Yes
Yes
Agam\AgaP_AGAP004769
5 of 12
No
No
Agam\AgaP_AGAP002219
4 of 12
No
No
Agam\AgaP_AGAP002812
3 of 12
No
No
Agam\AgaP_AGAP001902
2 of 12
No
No
Agam\AgaP_AGAP002563
2 of 12
No
No
Agam\AgaP_AGAP003577
2 of 12
No
No
Agam\AgaP_AGAP005159
2 of 12
No
No
Agam\AgaP_AGAP005243
2 of 12
No
No
Agam\AgaP_AGAP005248
2 of 12
No
No
Agam\AgaP_AGAP005302
2 of 12
No
No
Agam\AgaP_AGAP006025
2 of 12
No
No
Agam\AgaP_AGAP007369
2 of 12
No
No
Agam\AgaP_AGAP007615
2 of 12
No
No
Agam\AgaP_AGAP007681
2 of 12
No
No
Agam\AgaP_AGAP008224
2 of 12
No
No
Agam\AgaP_AGAP008989
2 of 12
No
No
Agam\AgaP_AGAP011306
2 of 12
No
No
Agam\AgaP_AGAP012108
2 of 12
No
No
Agam\AgaP_AGAP001211
1 of 12
No
No
Agam\AgaP_AGAP001573
1 of 12
No
No
Agam\AgaP_AGAP001617
1 of 12
No
No
Agam\AgaP_AGAP002092
1 of 12
No
No
Agam\AgaP_AGAP003028
1 of 12
No
No
Agam\AgaP_AGAP004146
1 of 12
No
No
Agam\AgaP_AGAP005255
1 of 12
No
No
Agam\AgaP_AGAP005393
1 of 12
No
No
Agam\AgaP_AGAP006279
1 of 12
No
No
Agam\AgaP_AGAP009325
1 of 12
No
No
Agam\AgaP_AGAP010875
1 of 12
No
No
Agam\AgaP_AGAP011283
1 of 12
No
No
Agam\AgaP_AGAP011363
1 of 12
No
No
Agam\CDC42_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (29)
Atha\ARA7
1 of 13
Yes
No
Atha\AT5G59840
1 of 13
Yes
No
Atha\ATFP8
1 of 13
Yes
No
Atha\GB2
1 of 13
Yes
No
Atha\RA-5
1 of 13
Yes
No
Atha\RAB1A
1 of 13
Yes
No
Atha\RAB1C
1 of 13
Yes
No
Atha\RAB6A
1 of 13
Yes
No
Atha\RAB7A
1 of 13
Yes
No
Atha\RAB7B
1 of 13
Yes
No
Atha\RAB8
1 of 13
Yes
No
Atha\RAB11c
1 of 13
Yes
No
Atha\RABA1d
1 of 13
Yes
No
Atha\RABA1g
1 of 13
Yes
No
Atha\RABA1i
1 of 13
Yes
No
Atha\RABA4a
1 of 13
Yes
No
Atha\RABA5d
1 of 13
Yes
No
Atha\RABB1a
1 of 13
Yes
No
Atha\RABC2A
1 of 13
Yes
No
Atha\RABE1c
1 of 13
Yes
No
Atha\RABE1e
1 of 13
Yes
No
Atha\RABG1
1 of 13
Yes
No
Atha\RABG3A
1 of 13
Yes
No
Atha\RABG3B
1 of 13
Yes
No
Atha\RABG3d
1 of 13
Yes
No
Atha\RABG3E
1 of 13
Yes
No
Atha\RABH1c
1 of 13
Yes
No
Atha\RABH1d
1 of 13
Yes
No
Atha\RABH1e
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\RSR1
8 of 13
Yes
Yes
Scer\RAS1
4 of 13
No
No
Scer\RAS2
4 of 13
No
No
Scer\RHB1
2 of 13
No
No
Scer\CDC42
1 of 13
No
No
1  
Scer\SEC4
1 of 13
No
No
Scer\VPS21
1 of 13
No
No
Scer\YPT1
1 of 13
No
No
Scer\YPT6
1 of 13
No
No
Scer\YPT53
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\ras1
5 of 12
Yes
No
Spom\rhb1
2 of 12
No
No
Spom\ypt1
1 of 12
No
No
Spom\ypt3
1 of 12
No
No
Spom\ypt7
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rap1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (33)
Rap2l
7 of 13
Ras85D
7 of 13
Ras64B
6 of 13
CG8500
4 of 13
CG13375
4 of 13
Rala
4 of 13
Rheb
4 of 13
Ric
4 of 13
CG5160
3 of 13
CG8519
3 of 13
CG8641
3 of 13
CG14669
3 of 13
CG30158
3 of 13
Rgk3
3 of 13
CG42541
2 of 13
κB-Ras
2 of 13
Rgk2
2 of 13
Cdc42
1 of 13
Rab1
1 of 13
Rab2
1 of 13
Rab5
1 of 13
Rab6
1 of 13
Rab7
1 of 13
Rab18
1 of 13
Rab19
1 of 13
Rab21
1 of 13
Rab26
1 of 13
Rab30
1 of 13
Rab35
1 of 13
RabX2
1 of 13
RabX6
1 of 13
Rgk1
1 of 13
RhoL
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Rap1RNAi.UAS.cUa
    exacerbates  cancer
    modeled by DeltaUAS.cDa, lolaGS88A8, psqGS88A8
    (Even et al., 2019)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAP1A; RAP1A, member of RAS oncogene family
    12 of 14
    179520
         
        RAP1B; RAP1B, member of RAS oncogene family
        11 of 14
        179530
           
          RAP1BL; RAP1B like (pseudogene)
          7 of 14
              RAP2A; RAP2A, member of RAS oncogene family
              5 of 14
              179540
                  RAP2B; RAP2B, member of RAS oncogene family
                  5 of 14
                  179541
                      RAP2C; RAP2C, member of RAS oncogene family
                      5 of 14
                      301016
                          HRAS; HRas proto-oncogene, GTPase
                          4 of 14
                          HRAS PROTOONCOGENE, GTPase; HRAS
                           
                          KRAS; KRAS proto-oncogene, GTPase
                          4 of 14
                          KRAS PROTOONCOGENE, GTPase; KRAS
                           
                          NRAS; NRAS proto-oncogene, GTPase
                          4 of 14
                          164790
                          RRAS2; RAS related 2
                          4 of 14
                          RELATED RAS VIRAL ONCOGENE HOMOLOG 2; RRAS2
                           
                          RRAS; RAS related
                          3 of 14
                          165090
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Dmel gene
                              Ortholog showing functional complementation
                              Supporting References
                              Rap1
                              Hsap\RAP1B
                              (Maywald et al., 2022)
                              Interactions
                              Summary of Physical Interactions
                              Interaction Browsers
                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                              Please see the Physical Interaction reports below for full details
                              RNA-protein
                              Physical Interaction
                              Assay
                              References
                              Rap1 - stau
                              anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization
                              (Laver et al., 2013)
                              protein-protein
                              Physical Interaction
                              Assay
                              References
                              Rap1 - CG12012
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - CG1416
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - CG15098
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - CG3164
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - CG5885
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Ldh
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Mec2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Ost48
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - PDZ-GEF
                              two hybrid
                              (Boettner and Van Aelst, 2007)
                              Rap1 - Rab1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Rab5
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Raf
                              two hybrid, anti tag coimmunoprecipitation, anti tag western blot
                              (Ding et al., 2010, Mishra et al., 2005)
                              Rap1 - Rdh1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Rgl
                              two hybrid
                              (Mirey et al., 2003)
                              Rap1 - Rpt1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - SERCA
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Tapδ
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - Tspo
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - UQCR-C2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - aPKC
                              anti tag coimmunoprecipitation, western blot
                              (Carmena et al., 2011)
                              Rap1 - cno
                              two hybrid, molecular sieving, static light scattering, isothermal titration calorimetry, predetermined participant
                              (McParland et al., 2024, Boettner and Van Aelst, 2007, Boettner et al., 2003)
                              Rap1 - hpo
                              enzymatic study, western blot, pull down, anti tag western blot
                              (Chang et al., 2018)
                              Rap1 - l(1)G0320
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - msn
                              anti tag coimmunoprecipitation, anti tag western blot
                              (Roberto et al., 2025)
                              Rap1 - mt:CoII
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Rap1 - par-6
                              anti tag coimmunoprecipitation, western blot
                              (Carmena et al., 2011)
                              Rap1 - pico
                              two hybrid
                              (Lyulcheva et al., 2008)
                              Summary of Genetic Interactions
                              Interaction Browsers
                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                              Please look at the allele data for full details of the genetic interactions
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Rap1
                              suppressible
                              cno
                              (Boettner et al., 2003)
                              Rap1
                              enhanceable
                              dap
                              (de Nooij et al., 1996)
                              Rap1
                              suppressible
                              Epac
                              (Dupuy et al., 2005)
                              Rap1
                              enhanceable
                              faf
                              (Li et al., 1997)
                              Rap1
                              suppressible
                              mys
                              (Huelsmann et al., 2006)
                              Rap1
                              suppressible
                              Rala
                              (Mirey et al., 2003)
                              Rap1
                              enhanceable
                              Rgl
                              (Mirey et al., 2003)
                              Rap1
                              suppressible
                              Rgl
                              (Mirey et al., 2003)
                              Rap1
                              suppressible
                              RhoL
                              (Siekhaus et al., 2010)
                              Rap1
                              suppressible
                              rl
                              (Mavromatakis and Tomlinson, 2012)
                              Rap1
                              suppressible
                              Vav
                              (Kim et al., 2024)
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              C3G
                              suppressible
                              Rap1
                              (Ishimaru et al., 1999)
                              cnk
                              enhanceable
                              Rap1
                              (Baril et al., 2014)
                              cno
                              enhanceable
                              Rap1
                              (Boettner et al., 2003)
                              da
                              suppressible
                              Rap1
                              (Reddy Onteddu et al., 2024)
                              Delta
                              enhanceable
                              Rap1
                              (Even et al., 2019)
                              emc
                              suppressible
                              Rap1
                              (Reddy Onteddu et al., 2024)
                              lola|psq|Delta
                              enhanceable
                              Rap1
                              (Even et al., 2019)
                              pbl
                              enhanceable
                              Rap1
                              (Gregory et al., 2007)
                              PDZ-GEF
                              suppressible
                              Rap1
                              (Boettner and Van Aelst, 2007, Huelsmann et al., 2006, Wang et al., 2006, Lee et al., 2002)
                              PDZ-GEF
                              enhanceable
                              Rap1
                              (Boettner and Van Aelst, 2007, Singh et al., 2006)
                              Psn
                              enhanceable
                              Rap1
                              (Mahoney et al., 2006)
                              Raf
                              enhanceable
                              Rap1
                              (Baril et al., 2014)
                              Rala
                              suppressible
                              Rap1
                              (Mirey et al., 2003)
                              RapGAP1
                              enhanceable
                              Rap1
                              (Chen et al., 1997)
                              sev
                              suppressible
                              Rap1
                              (Mavromatakis and Tomlinson, 2012)
                              Shrm
                              enhanceable
                              Rap1
                              (Hildebrand et al., 2021)
                              sns
                              suppressible
                              Rap1
                              (Maywald et al., 2022)
                              α-Cat
                              enhanceable
                              Rap1
                              (Sheppard et al., 2023)
                              External Data
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              MIST (genetic) - An integrated Molecular Interaction Database
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Class of Gene
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              3L
                              Recombination map
                              3-1.0
                              Cytogenetic map
                              62B7-62B7
                              Sequence location
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              62B7-62B7
                              Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              62B-62B
                              (determined by in situ hybridisation)
                              (Neuman-Silberberg et al., 1984)
                              Experimentally Determined Recombination Data
                              Location

                              3-1.0

                              (FlyBase, 2016)

                              3-3.0

                              (Comeron et al., 2012)

                              3-1.4

                              Left of (cM)
                              (Johnson and Friedman, 1983)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (27)
                              Genomic Clones (14)
                               

                              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                              cDNA Clones (108)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequenced
                              BDGP DGC clones
                              Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Cell Line Information
                              Publicly Available Cell Lines
                               
                                Other Stable Cell Lines
                                 
                                  Other Comments

                                  R is required for macrophage shape and migration during embryogenesis.

                                  (Huelsmann et al., 2006)

                                  R and cno proteins act in the same molecular pathway during dorsal closure and the function of both proteins in dorsal closure depends on their ability to interact with each other. R acts upstream of cno in dorsal closure, but unlike cno, is not involved in the stimulation of JNK pathway activity.

                                  (Boettner et al., 2003)

                                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                  (Kiger et al., 2003)

                                  RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cells become round and detached.

                                  (Kiger et al., 2003)

                                  Cells mutant for R condense their adherens junctions to one side of the cell in clones in the wing. This disrupts normal epithelial cell behaviour, leading to the mutant cell clones dispersing into the surrounding wild-type tissue.

                                  (Knox and Brown, 2002)

                                  Ras85D-mediated signalling pathways are not influenced by R levels. Ras85D and R seem to function via distinct pathways. R has a regulatory role in morphogenesis in the eye, ovary and embryo. R also plays a role cell migration and cell shaping.

                                  (Asha et al., 1999)

                                  Candidate gene for quantitative trait locus.

                                  (Macdonald and Goldstein, 1999)

                                  Analysis of genetic interactions among faf and R and Ras85D reveals that in addition to its critical role anterior to the morphogenetic furrow, faf has a function in undifferentiated cells alter in eye development that involves, probably indirectly, Ras85D and R. These results suggest that cells outside the facet influence cell fates within the facet.

                                  (Li et al., 1997)

                                  R is essential for cell proliferation although it is not required for cell survival in post-mitotic cells. It is also required during oogenesis.

                                  (Asha and Hariharan, 1995)

                                  R mutations disrupt the normal cell fate specification in photoreceptor cells.

                                  (Hariharan et al., 1991)

                                  The transcription pattern of R was analyzed in neuroblasts derived from tumorous larval brain of l(2)gl larvae and S2 tissue culture cells. R expresses constitutive as well as maternal/embryonic-specific transcripts.

                                  (Kimchie et al., 1989)

                                  An unusually low recovery rate of certain classes of deletions for the R locus suggests that a chromosome interval within 62B3-4 to 62D3-4 may be dominantly sensitive to position effects.

                                  (Sliter et al., 1989)

                                  Isolated as a Ras homologue, but also found to share high homology with human Rap.

                                  Relationship to Other Genes
                                  Source for database merge of

                                  Source for merge of: R BEST:GH18528

                                  (Rana, 2004.7.8)
                                  Additional comments
                                  Nomenclature History
                                  Source for database identify of

                                  Source for identity of: R CG1956

                                  (Deng, 1999.11)

                                  Source for identity of: Rap1 R

                                  (FlyBase, 2009-)
                                  Nomenclature comments

                                  Renamed from 'R' to 'Rap1' to represent community usage and to minimise confusion with the 'r' ('rudimentary') gene symbol, from which it differed only by case.

                                  (FlyBase, 2009-)
                                  Etymology
                                  Synonyms and Secondary IDs (27)
                                  Reported As
                                  Symbol Synonym
                                  BEST:GH18528
                                  C-ras3
                                  CG1956
                                  (Kolkhof et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Cermelli et al., 2006, Walker et al., 2006, Colicelli, 2004)
                                  D-Rap1
                                  (Dupuy et al., 2005, Mishra et al., 2005)
                                  DRap
                                  (Balakireva et al., 2001)
                                  DRap1
                                  (Boettner et al., 2001)
                                  Dras3
                                  (Andolfatto, 2001, Aquadro et al., 2001, Gasperini and Gibson, 1999, Gibson et al., 1999, Dobrovolskaia and Belitsky, 1997, Hariharan et al., 1991, Pizon et al., 1988)
                                  Dras62B
                                  (Dobrovolskaia and Belitsky, 1997)
                                  E(faf)
                                  (Fischer et al., 1997)
                                  EC3-7
                                  (Baril et al., 2014)
                                  FCG-C
                                  (Horne-Badovinac et al., 2012)
                                  P08645
                                  (Rojas et al., 2012)
                                  R
                                  (Keder et al., 2015, Baril et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Ardehali et al., 2011, Diez et al., 2011, Friedman et al., 2011, Cook et al., 2010.2.12, Laffafian et al., 2010, Tan et al., 2009, Wang et al., 2009, Krishnamoorthy, 2008, Huang et al., 2007, Stuart et al., 2007, Cermelli et al., 2006, Mahoney et al., 2006)
                                  RAP1
                                  (Toba et al., 1999)
                                  Rap
                                  (Chen et al., 2013, Mavromatakis and Tomlinson, 2013, Mavromatakis and Tomlinson, 2012, Singh et al., 2006, Martin, 2004, Lee et al., 2002)
                                  Rap1
                                  (Bischoff et al., 2025, Durel et al., 2025, Roberto et al., 2025, Ko et al., 2024, McParland et al., 2024, Reddy Onteddu et al., 2024, Burghardt et al., 2023, Koehler and Huber, 2023, Perez-Vale et al., 2023, Beaver et al., 2022, Aromolaran et al., 2021, Harnish et al., 2021, Perez-Vale et al., 2021, Gheisari et al., 2020, Jossin, 2020, Samuels et al., 2020, Sun et al., 2020, Volovetz et al., 2020, Chang et al., 2019, Dlugos et al., 2019, Hall et al., 2019, Meltzer et al., 2019, Rotelli et al., 2019, Bonello et al., 2018, Camp et al., 2018, Sawant et al., 2018, Gilmour et al., 2017, Clandinin and Owens, 2016-, Parsons and Foley, 2016, Yang et al., 2016, Yoo et al., 2016, Biersmith et al., 2015, Keder et al., 2015, Vlisidou and Wood, 2015, Baril et al., 2014, Wang et al., 2014, Eguchi et al., 2013, Ellis et al., 2013, Guichard et al., 2013, Wang et al., 2013, Coló et al., 2012, Kelsom and Lu, 2012, Spahn et al., 2012, Ding et al., 2010, McMahon et al., 2010, Shirinian et al., 2010, Siekhaus et al., 2010, Franzdóttir et al., 2009, O'Keefe et al., 2009, Sawyer et al., 2009, Ghiglione et al., 2008, Ghiglione et al., 2008, Gonzalez et al., 2008, Harris et al., 2008, Lyulcheva et al., 2008, Ott et al., 2008, Zhang and Therrien, 2008, Boettner and Van Aelst, 2007, Walker et al., 2006, Wang et al., 2006, Hariharan, 2005, Brumby et al., 2004, Boettner et al., 2003, Perez-Moreno et al., 2003, Knox and Brown, 2002, Lee et al., 2002, Tepass, 2002, Braga and Harwood, 2001, Gulli and Peter, 2001, Asha et al., 1999, Ishimaru et al., 1999, Ishimaru et al., 1999, Knox and Brown, 1999, Ridley, 1999, Chen et al., 1997, Fischer et al., 1997, Li et al., 1997, Asha and Hariharan, 1996, Chen et al., 1996, de Nooij et al., 1996, Asha and Hariharan, 1995, Hariharan et al., 1995, Dickson and Hafen, 1993, Hariharan et al., 1991, Simon et al., 1991)
                                  Ras3
                                  RasIII
                                  (Lakhotia et al., 1999)
                                  l(3)62Bf
                                  (Lindsley and Zimm, 1992)
                                  l(3)R
                                  (Sliter et al., 1989)
                                  rap1
                                  (Rothenberg et al., 2023, Maywald et al., 2022, Schmidt et al., 2022, Ou et al., 2019, Schmidt et al., 2018, Heo et al., 2017, Horne-Badovinac et al., 2012, Huelsmann et al., 2006, Dobens and Raftery, 2000)
                                  ras 3
                                  (McVean and Vieira, 2001)
                                  ras3
                                  (Gasperini, 1999.8.27)
                                  Name Synonyms
                                  Enhancer of faf
                                  (Fischer et al., 1997)
                                  Rap1 GTPase
                                  (Siekhaus et al., 2010)
                                  Roughened
                                  (Even et al., 2019, Laver et al., 2013, Wang et al., 2013, Jaspers et al., 2012, Mavromatakis and Tomlinson, 2012, Cammarato et al., 2011, O'Keefe et al., 2009, Krishnamoorthy, 2008, Zhou et al., 2008, Gregory et al., 2007, Hariharan, 2005)
                                  roughened
                                  (Keder et al., 2015, Cermelli et al., 2006)
                                  Secondary FlyBase IDs
                                  • FBgn0003190
                                  • FBgn0003207
                                  • FBgn0045818
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  Study result (0)
                                  Result
                                  Result Type
                                  Title
                                  External Crossreferences and Linkouts ( 62 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                  Other crossreferences
                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                  FlyMine - An integrated database for Drosophila genomics
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  DroID - A comprehensive database of gene and protein interactions.
                                  DRSC - Results frm RNAi screens
                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  Flygut - An atlas of the Drosophila adult midgut
                                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                  MIST (genetic) - An integrated Molecular Interaction Database
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                  References (247)