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FB2026_01
,
released March 12, 2026
PKC, eye-PKC, protein kinase C, dPKC53E(ey), PKCi
Please see the JBrowse view of Dmel\inaC for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
2.5 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
700 (aa)
Tetrapeptide ligand at C-terminus is tethered to inaD by interaction with the second PDZ domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\inaC using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
inaC transcripts are detected in late pupae and adults by northern blots. In adults they are found in RNA from heads but not bodies. In situ hybridization shows that they are specific to photoreceptor cells and are expressed in both the eye and the ocelli.
inaC protein is localized to the photoreceptor cells in both compound eyes and ocelli. Most of the signal is confined to the rhabdomeres of the photoreceptor cells. An inaCFBtr0091350:pb-XRlacZ reporter construct was used to show that it is expressed in all types of photoreceptor cells in the eye and ocelli.
JBrowse - Visual display of RNA-Seq signals
View Dmel\inaC in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in mitotic index seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Intracellular voltage clamping demonstrated that light adaptation is severely reduced in inaC mutants, suggesting that the eye specific PKC encoded by inaC is required for adaptation. Whole cell current recordings from isolated ommatidia showed that in the absence of PKC the single photon-induced quantum bumps fail to terminate normally.
The protein kinase C (PKC) enzyme in Drosophila is encoded by a gene family made up of three genes which are expressed primarily in adult flies. The deduced amino acid sequences of these genes are quite similar to each other and those of the mammalian PKC family (Schaeffer et al., 1989).
Structural gene for protein kinase C (PKC). Isolated from Drosophila clones obtained with mammalian probes. Expressed primarily in photoreceptors of adult flies. Mutant alleles have same basic phenotype as inaA; also, inaC lacks off transient of ERG and (in such physiological recordings) there is a slow return to baseline potential at stimulus offset. Structural gene for protein kinase C (PKC); expressed primarily in photoreceptors of adult flies. Mutant alleles have same basic phenotype as inaA; also, inaC lacks off transient of ERG and (in such physiological recordings) there is a slow return to baseline potential at stimulus offset.
