Gene model reviewed during 5.47
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TkR86C using the Feature Mapper tool.
Comment: 14-16 neurons
In adult brains and ventral nerve cords, Tkr86C protein is observed in bilateral pairs of neurons; immunoreactivity is observed in both cell bodies and in neuronal processes. In the adult protocerebrum, these include two dorsolateral pairs and one ventrolateral pair of cell bodies, and a median cluster of 14-16 cell bodies in median neurosecretory cell group of the pars intercerebralis. There are two pairs of immunoreactive cells in adult gnathal (subesophageal) ganglion, and four to five pairs of neurons localized laterally in the abdominal neuromeres of the thoracico-abdominal ganglion. In wandering third instar larval CNS, Tkr86C protein is observed in at least four pairs of neuronal cell bodies in the anterior protocerebrum, four pairs of cell bodies in the subesophageal ganglion, seven pairs of cell bodies in the first three abdominal neuromeres, and three pairs of cell bodies in the seventh and eighth abdominal neuromeres. In the adult intestine, punctate Tkr86C immunoreactivity is observed in the circular muscle layer of the midgut, and in endocrine cells of the posterior midgut.
GBrowse - Visual display of RNA-Seq signalsView Dmel\TkR86C in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: TkR86C Takr86C
Symbol changed from 'Takr86C' to 'TkR86C' to be consistent with the nomenclature used for the ligand ('Tk') and to be more in line with usage in the literature.
Takr86C encodes a neuropeptide homologous to the mammalian tachykinin NK3 receptor and may play a role in axonal pathfinding.