FB2025_04 , released October 2, 2025
Gene: Dmel\B-H2
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General Information
Symbol
Dmel\B-H2
Species
D. melanogaster
Name
BarH2
Annotation Symbol
CG5488
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004854
Gene Model Status
Current
Stock Availability
30 publicly available
Gene Summary
B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. (UniProt, Q24256)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Bar, BH2

Key Links
Genomic Location
Cytogenetic map
16A1-16A1
Sequence location
Recombination map
1-57
RefSeq locus
NC_004354 REGION:17314581..17324175
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from mutant phenotype
(Lim and Choi, 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR020479
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001551673
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR017970
(InterPro Project Members, 2004-)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001551673
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in chaeta morphogenesis
inferred from mutant phenotype
(Sato et al., 1999)
involved_in compound eye photoreceptor cell differentiation
inferred from mutant phenotype
(Higashijima et al., 1992)
involved_in eye pigment granule organization
inferred from mutant phenotype
(Higashijima et al., 1992)
involved_in eye-antennal disc morphogenesis
inferred from mutant phenotype
(Kojima et al., 2000)
involved_in leg disc proximal/distal pattern formation
inferred from mutant phenotype
(Kojima et al., 2000)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Lim and Choi, 2003)
involved_in sensory organ boundary specification
inferred from mutant phenotype
(Higashijima et al., 1992)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR017970
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001551673
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001551673
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred by curator from GO:0000981
(Lim and Choi, 2003)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Antp homeobox family. (Q24256)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
NK-like (NKL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. NKL transcription factors are homeobox genes closely related to Hox-like genes, a number of which are found in the NK cluster. Many of the NKL members contain an Engrailed Homology 1 (EH1) motif. (Adapted from FBrf0232555 and PMID:22094586).
Protein Function (UniProtKB)
B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.
(UniProt, Q24256)
Summary (Interactive Fly)

transcription factor - homeodomain - neural selector genes involved in the development of the external sensilli - part of a transcription factor network that patterns the developing olfactory tissue - transcriptional repression of atonal by Bar prevents ectopic retinal neurogenesis

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\B-H2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24256)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
B-H2-RA
FBtr0074429
NM_078662
3102
645
B-H2-RB
FBtr0334458
NM_001272712
3142
303
Additional Transcript Data and Comments
Reported size (kB)

3.8 (northern blot)

(Higashijima et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
B-H2-PA
FBpp0074203
70.0
645
6.87
Q24256
NP_523386
AAF48725
B-H2-PB
FBpp0306534
33.2
303
5.29
M9PHF0
NP_001259641
AGB95483
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

642 (aa)

(Higashijima et al., 1992)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\B-H2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.12

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuron
(Higashijima et al., 1992)
peripheral nervous system
(Higashijima et al., 1992)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Higashijima et al., 1992)
thecogen cell
(Higashijima et al., 1992)
external sensory organ
(Higashijima et al., 1992)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
gnathal primordium

Comment: reported as gnathal lobes anlage

(Fisher et al., 2012)
embryonic stage 11 -- 12
antennal primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
labial sensory complex primordium
(Fisher et al., 2012)
maxillary sensory complex primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
Additional Descriptive Data

B-H1 and B-H2 expression was described in embryos. They are coexpressed in intersegmental, dorsal epidermal cells and in some CNS cells. In the PNS, they are expressed in es neurons and a fraction of their support cells.

(Higashijima et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuron
(Higashijima et al., 1992)
peripheral nervous system
(Higashijima et al., 1992)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
thecogen cell
(Higashijima et al., 1992)
presumptive embryonic/larval central nervous system
(Higashijima et al., 1992)
external sensory organ
(Higashijima et al., 1992)
neuroblast NB3-2
(Lacin and Truman, 2016)
neuroblast NB5-4
(Lacin and Truman, 2016)
larval stage
neuroblast NB5-4
(Lacin and Truman, 2016)
third instar larval stage
tarsal segment 5
(Sakurai et al., 2007)
late third instar larval stage -- pharate adult stage P13
photoreceptor cell R6 | precursor
(Higashijima et al., 1992)
pupal stage P6 -- pharate adult stage P15
primary pigment cell

Comment: reference states >20 hr APF

(Higashijima et al., 1992)
Additional Descriptive Data

The B-H1 and B-H2 proteins are detected in the R1/R6 prephotoreceptor pair from late third larval instar to early pupal stages. Anterior and posterior primary pigment cells of the developing ommatidium are labeled starting at 20 hours of pupariation and continuing until at least 80 hours of pupariation.

(Higashijima et al., 1992)

B-H1 and B-H2 protein expression was described in embryos. They are coexpressed in intersegmental, dorsal epidermal cells and in some CNS cells. In the PNS, they are expressed in es neurons and a fraction of their support cells.

(Higashijima et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{lArB}B-H2P058
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
presumptive tarsal segment 4 -- presumptive tarsal segment 5
(Natori et al., 2012)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\B-H2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of B-H2
Transgenic constructs containing regulatory region of B-H2
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (111)
Hsap\BARHL1
10 of 14
Yes
Yes
Hsap\BARHL2
9 of 14
No
No
Hsap\BARX1
4 of 14
No
Yes
Hsap\BARX2
4 of 14
No
Yes
Hsap\DBX1
2 of 14
No
No
Hsap\DBX2
2 of 14
No
No
Hsap\LBX1
2 of 14
No
No
Hsap\NKX1-1
2 of 14
No
No
Hsap\NKX1-2
2 of 14
No
No
Hsap\TLX1
2 of 14
No
No
Hsap\TLX2
2 of 14
No
No
Hsap\TLX3
2 of 14
No
No
Hsap\VENTX
2 of 14
No
Yes
Hsap\ALX3
1 of 14
No
No
Hsap\ALX4
1 of 14
No
No
Hsap\ARX
1 of 14
No
No
Hsap\BSX
1 of 14
No
No
Hsap\CDX4
1 of 14
No
No
Hsap\DLX1
1 of 14
No
No
Hsap\DLX2
1 of 14
No
No
Hsap\DLX3
1 of 14
No
No
1  
Hsap\DLX4
1 of 14
No
No
1  
Hsap\DLX5
1 of 14
No
No
Hsap\DLX6
1 of 14
No
No
Hsap\DMBX1
1 of 14
No
No
Hsap\DRGX
1 of 14
No
No
Hsap\DUX4
1 of 14
No
No
2  
Hsap\DUX4L4
1 of 14
No
Yes
Hsap\DUX4L7
1 of 14
No
Yes
Hsap\DUX4L9
1 of 14
No
Yes
Hsap\DUXA
1 of 14
No
Yes
Hsap\EMX1
1 of 14
No
No
Hsap\EMX2
1 of 14
No
No
Hsap\ESX1
1 of 14
No
No
Hsap\EVX1
1 of 14
No
No
Hsap\GBX1
1 of 14
No
No
Hsap\GBX2
1 of 14
No
No
1  
Hsap\GSX1
1 of 14
No
No
Hsap\GSX2
1 of 14
No
No
Hsap\HHEX
1 of 14
No
No
Hsap\HLX
1 of 14
No
No
Hsap\HMX1
1 of 14
No
No
Hsap\HMX2
1 of 14
No
No
Hsap\HMX3
1 of 14
No
No
Hsap\HOXA1
1 of 14
No
No
Hsap\HOXA3
1 of 14
No
No
Hsap\HOXA4
1 of 14
No
No
Hsap\HOXA5
1 of 14
No
No
1  
Hsap\HOXA6
1 of 14
No
No
Hsap\HOXA7
1 of 14
No
No
Hsap\HOXA10
1 of 14
No
No
1  
Hsap\HOXB1
1 of 14
No
No
Hsap\HOXB2
1 of 14
No
No
1  
Hsap\HOXB3
1 of 14
No
No
Hsap\HOXB4
1 of 14
No
No
Hsap\HOXB5
1 of 14
No
No
1  
Hsap\HOXB6
1 of 14
No
No
1  
Hsap\HOXB7
1 of 14
No
No
Hsap\HOXB8
1 of 14
No
No
Hsap\HOXC4
1 of 14
No
No
Hsap\HOXC6
1 of 14
No
No
Hsap\HOXC11
1 of 14
No
No
Hsap\HOXC12
1 of 14
No
No
Hsap\HOXD3
1 of 14
No
No
Hsap\HOXD4
1 of 14
No
No
2  
Hsap\HOXD8
1 of 14
No
No
Hsap\HOXD13
1 of 14
No
No
Hsap\ISX
1 of 14
No
No
Hsap\LBX2
1 of 14
No
No
2  
Hsap\LHX5
1 of 14
No
No
Hsap\LHX8
1 of 14
No
No
Hsap\MEOX1
1 of 14
No
No
1  
Hsap\MEOX2
1 of 14
No
No
Hsap\MNX1
1 of 14
No
No
Hsap\MSX1
1 of 14
No
No
Hsap\MSX2
1 of 14
No
No
Hsap\NANOG
1 of 14
No
No
Hsap\NANOGP1
1 of 14
No
Yes
Hsap\NKX2-1
1 of 14
No
No
Hsap\NKX2-2
1 of 14
No
No
Hsap\NKX2-5
1 of 14
No
No
Hsap\NKX2-6
1 of 14
No
No
Hsap\NKX2-8
1 of 14
No
No
Hsap\NKX3-1
1 of 14
No
No
Hsap\NKX3-2
1 of 14
No
No
Hsap\NKX6-1
1 of 14
No
No
1  
Hsap\NKX6-2
1 of 14
No
No
Hsap\NKX6-3
1 of 14
No
No
Hsap\NOTO
1 of 14
No
No
Hsap\NPM1
1 of 14
No
No
1  
Hsap\PAX3
1 of 14
No
No
1  
Hsap\PAX4
1 of 14
No
No
Hsap\PAX7
1 of 14
No
No
0  
Hsap\PDX1
1 of 14
No
No
Hsap\PHOX2A
1 of 14
No
No
Hsap\PHOX2B
1 of 14
No
No
Hsap\PITX3
1 of 14
No
No
1  
Hsap\PROP1
1 of 14
No
No
Hsap\PRRX1
1 of 14
No
No
Hsap\RAX2
1 of 14
No
No
Hsap\RAX
1 of 14
No
No
1  
Hsap\RHOXF1
1 of 14
No
No
Hsap\RHOXF2B
1 of 14
No
No
Hsap\RHOXF2
1 of 14
No
No
Hsap\SHOX2
1 of 14
No
No
Hsap\SHOX
1 of 14
No
No
1  
Hsap\UNCX
1 of 14
No
No
Hsap\VAX1
1 of 14
No
No
Hsap\VAX2
1 of 14
No
No
Hsap\VSX1
1 of 14
No
No
1  
Hsap\ZFHX3
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (66)
Rnor\Barhl1
9 of 14
Yes
Yes
Rnor\Barhl2
7 of 14
No
No
Rnor\Barx1
3 of 14
No
No
Rnor\Barx2
3 of 14
No
Yes
Rnor\Dbx1
2 of 14
No
No
Rnor\Nkx1-1
2 of 14
No
No
Rnor\Nkx1-2
2 of 14
No
No
Rnor\Alx3
1 of 14
No
No
Rnor\Alx4
1 of 14
No
No
Rnor\Arx
1 of 14
No
No
Rnor\Bsx
1 of 14
No
No
Rnor\Dbx2
1 of 14
No
No
Rnor\Dlx3
1 of 14
No
No
Rnor\Dlx4
1 of 14
No
No
Rnor\Dlx5
1 of 14
No
No
Rnor\Dlx6
1 of 14
No
No
Rnor\Drgx
1 of 14
No
No
Rnor\Emx1
1 of 14
No
No
Rnor\Emx2
1 of 14
No
No
Rnor\Gbx1
1 of 14
No
No
Rnor\Gbx2
1 of 14
No
No
Rnor\Gsx2
1 of 14
No
No
Rnor\Hlx
1 of 14
No
No
Rnor\Hmx1
1 of 14
No
No
Rnor\Hmx2
1 of 14
No
No
Rnor\Hmx3
1 of 14
No
No
Rnor\Hoxb2
1 of 14
No
No
Rnor\Hoxb4
1 of 14
No
No
Rnor\Hoxb5
1 of 14
No
No
Rnor\Isx
1 of 14
No
No
Rnor\Lbx1
1 of 14
No
No
Rnor\Lbx2
1 of 14
No
No
Rnor\Lhx5
1 of 14
No
No
Rnor\LOC100364002
1 of 14
No
No
Rnor\Meox1
1 of 14
No
No
Rnor\Mnx1
1 of 14
No
No
Rnor\Msx1
1 of 14
No
No
Rnor\Msx2
1 of 14
No
No
Rnor\Msx3
1 of 14
No
No
Rnor\Nkx2-2
1 of 14
No
No
Rnor\Nkx2-6
1 of 14
No
No
Rnor\Nkx2-8
1 of 14
No
No
Rnor\Nkx3-1
1 of 14
No
No
Rnor\Nkx3-2
1 of 14
No
No
Rnor\Nobox
1 of 14
No
No
Rnor\Noto
1 of 14
No
No
Rnor\Npm1
1 of 14
No
No
Rnor\Pax7
1 of 14
No
No
Rnor\Pitx3
1 of 14
No
No
Rnor\Pou5f1
1 of 14
No
No
Rnor\Prrx2
1 of 14
No
No
Rnor\Rax
1 of 14
No
No
Rnor\Rhox2
1 of 14
No
Yes
Rnor\Rhox3
1 of 14
No
Yes
Rnor\Rhox4g
1 of 14
No
Yes
Rnor\Rhox8
1 of 14
No
No
Rnor\Rhox10
1 of 14
No
No
Rnor\Rhox12
1 of 14
No
No
Rnor\Rhox13
1 of 14
No
No
Rnor\Shox2
1 of 14
No
No
Rnor\Tlx1
1 of 14
No
No
Rnor\Uncx
1 of 14
No
No
Rnor\Vax1
1 of 14
No
No
Rnor\Vax2
1 of 14
No
No
Rnor\Vsx1
1 of 14
No
No
Rnor\Zfhx3
1 of 14
No
No
Mus musculus (laboratory mouse) (88)
Mmus\Barhl1
9 of 14
Yes
Yes
Mmus\Barhl2
7 of 14
No
No
Mmus\Barx1
3 of 14
No
No
Mmus\Barx2
3 of 14
No
Yes
Mmus\Dbx1
2 of 14
No
No
Mmus\Lbx2
2 of 14
No
No
Mmus\Nkx1-1
2 of 14
No
No
Mmus\Nkx1-2
2 of 14
No
No
Mmus\Alx3
1 of 14
No
No
Mmus\Arx
1 of 14
No
No
Mmus\Bsx
1 of 14
No
No
Mmus\Dbx2
1 of 14
No
No
Mmus\Dlx2
1 of 14
No
No
Mmus\Dlx3
1 of 14
No
No
Mmus\Dlx4
1 of 14
No
No
Mmus\Dlx5
1 of 14
No
No
Mmus\Dlx6
1 of 14
No
No
Mmus\Emx1
1 of 14
No
No
Mmus\Emx2
1 of 14
No
No
1  
Mmus\Gbx1
1 of 14
No
No
Mmus\Gbx2
1 of 14
No
No
Mmus\Gsc2
1 of 14
No
No
Mmus\Hlx
1 of 14
No
No
Mmus\Hmx1
1 of 14
No
No
Mmus\Hmx2
1 of 14
No
No
Mmus\Hmx3
1 of 14
No
No
Mmus\Hoxa4
1 of 14
No
No
Mmus\Hoxb4
1 of 14
No
No
0  
Mmus\Hoxb5
1 of 14
No
No
Mmus\Hoxb7
1 of 14
No
No
Mmus\Hoxc4
1 of 14
No
No
Mmus\Hoxd4
1 of 14
No
No
Mmus\Lbx1
1 of 14
No
No
Mmus\Lhx5
1 of 14
No
No
Mmus\Meox1
1 of 14
No
No
Mmus\Mnx1
1 of 14
No
No
Mmus\Msx1
1 of 14
No
No
Mmus\Msx2
1 of 14
No
No
0  
Mmus\Msx3
1 of 14
No
No
Mmus\Nkx2-2
1 of 14
No
No
Mmus\Nkx2-5
1 of 14
No
No
5  
Mmus\Nkx2-6
1 of 14
No
No
Mmus\Nkx2-9
1 of 14
No
No
Mmus\Nkx3-1
1 of 14
No
No
Mmus\Nkx3-2
1 of 14
No
No
Mmus\Npm1
1 of 14
No
No
Mmus\Obox1
1 of 14
No
No
Mmus\Obox6
1 of 14
No
No
Mmus\Pax7
1 of 14
No
No
Mmus\Pitx3
1 of 14
No
No
Mmus\Pou5f1
1 of 14
No
No
Mmus\Prrxl1
1 of 14
No
No
Mmus\Rhox1
1 of 14
No
Yes
Mmus\Rhox2a
1 of 14
No
Yes
Mmus\Rhox2b
1 of 14
No
Yes
Mmus\Rhox2c
1 of 14
No
Yes
Mmus\Rhox2d
1 of 14
No
Yes
Mmus\Rhox2e
1 of 14
No
Yes
Mmus\Rhox2f
1 of 14
No
Yes
Mmus\Rhox2g
1 of 14
No
Yes
Mmus\Rhox2h
1 of 14
No
Yes
Mmus\Rhox3a2
1 of 14
No
Yes
Mmus\Rhox3a
1 of 14
No
Yes
Mmus\Rhox3c
1 of 14
No
Yes
Mmus\Rhox3e
1 of 14
No
Yes
Mmus\Rhox3f
1 of 14
No
Yes
Mmus\Rhox3g
1 of 14
No
Yes
Mmus\Rhox3h
1 of 14
No
Yes
Mmus\Rhox4a2
1 of 14
No
Yes
Mmus\Rhox4a
1 of 14
No
Yes
Mmus\Rhox4b
1 of 14
No
Yes
Mmus\Rhox4c
1 of 14
No
Yes
Mmus\Rhox4d
1 of 14
No
Yes
Mmus\Rhox4e
1 of 14
No
Yes
Mmus\Rhox4f
1 of 14
No
Yes
Mmus\Rhox4g
1 of 14
No
Yes
Mmus\Rhox6
1 of 14
No
Yes
Mmus\Rhox7a
1 of 14
No
Yes
Mmus\Rhox7b
1 of 14
No
Yes
Mmus\Rhox9
1 of 14
No
Yes
Mmus\Rhox10
1 of 14
No
No
Mmus\Rhox13
1 of 14
No
No
Mmus\Shox2
1 of 14
No
No
Mmus\Tlx1
1 of 14
No
No
Mmus\Tlx2
1 of 14
No
No
Mmus\Tlx3
1 of 14
No
No
Mmus\Uncx
1 of 14
No
No
Mmus\Vax1
1 of 14
No
No
1  
Xenopus tropicalis (Western clawed frog) (91)
Xtro\barhl1
7 of 13
Yes
Yes
Xtro\barhl2
7 of 13
Yes
Yes
Xtro\LOC100490929
7 of 13
Yes
Yes
Xtro\barx1
2 of 13
No
Yes
Xtro\barx2
2 of 13
No
Yes
Xtro\alx4
1 of 13
No
No
Xtro\ankef1
1 of 13
No
Yes
Xtro\arx
1 of 13
No
No
Xtro\bsx
1 of 13
No
No
Xtro\cdx4
1 of 13
No
No
Xtro\chn1
1 of 13
No
No
Xtro\crybb2
1 of 13
No
No
Xtro\cuedc2
1 of 13
No
No
Xtro\dbx1
1 of 13
No
No
Xtro\dbx2
1 of 13
No
No
Xtro\dlx2
1 of 13
No
No
Xtro\dlx5
1 of 13
No
No
Xtro\dlx6
1 of 13
No
No
Xtro\dmbx1
1 of 13
No
No
Xtro\drgx
1 of 13
No
No
Xtro\emx1l
1 of 13
No
No
Xtro\emx1
1 of 13
No
No
Xtro\evx1
1 of 13
No
No
Xtro\evx2
1 of 13
No
No
Xtro\gbx2.1
1 of 13
No
No
Xtro\gsx1
1 of 13
No
No
Xtro\hesx1
1 of 13
No
Yes
Xtro\hhex
1 of 13
No
No
Xtro\hmx1
1 of 13
No
No
Xtro\hmx2
1 of 13
No
No
Xtro\hmx3
1 of 13
No
No
Xtro\hoxa1
1 of 13
No
No
Xtro\hoxa3
1 of 13
No
No
Xtro\hoxa4
1 of 13
No
No
Xtro\hoxa5
1 of 13
No
No
Xtro\hoxa7
1 of 13
No
No
Xtro\hoxb2
1 of 13
No
No
Xtro\hoxb3
1 of 13
No
No
Xtro\hoxb5
1 of 13
No
No
Xtro\hoxb8
1 of 13
No
No
Xtro\hoxc3
1 of 13
No
No
Xtro\hoxc10
1 of 13
No
No
Xtro\hoxc12
1 of 13
No
Yes
Xtro\hoxc13
1 of 13
No
Yes
Xtro\hoxd1
1 of 13
No
No
Xtro\hoxd8
1 of 13
No
No
Xtro\lhx1
1 of 13
No
No
Xtro\LOC100485081
1 of 13
No
No
Xtro\LOC100485697
1 of 13
No
No
Xtro\LOC100486032
1 of 13
No
No
Xtro\LOC100487588
1 of 13
No
No
Xtro\LOC100492873
1 of 13
No
No
Xtro\LOC100493706
1 of 13
No
No
Xtro\LOC100496089
1 of 13
No
No
Xtro\LOC100497614
1 of 13
No
No
Xtro\LOC101731251
1 of 13
No
No
Xtro\LOC101731897
1 of 13
No
No
Xtro\LOC101732809
1 of 13
No
No
Xtro\med9
1 of 13
No
No
Xtro\meox2
1 of 13
No
No
Xtro\mnx1
1 of 13
No
No
Xtro\msx1
1 of 13
No
No
Xtro\msx2
1 of 13
No
No
Xtro\nkx1-1
1 of 13
No
No
Xtro\nkx2-1
1 of 13
No
No
Xtro\nkx2-5
1 of 13
No
No
Xtro\nkx2-6
1 of 13
No
No
Xtro\nkx3-2
1 of 13
No
No
Xtro\nkx3-3
1 of 13
No
No
Xtro\nkx6-2
1 of 13
No
No
Xtro\nkx6-3
1 of 13
No
No
Xtro\nobox
1 of 13
No
No
Xtro\not
1 of 13
No
No
Xtro\pdx1
1 of 13
No
No
Xtro\phox2b
1 of 13
No
No
Xtro\pitx2
1 of 13
No
No
Xtro\pitx3
1 of 13
No
No
Xtro\prrx1
1 of 13
No
No
Xtro\rax2
1 of 13
No
No
Xtro\shox2
1 of 13
No
No
Xtro\shox
1 of 13
No
No
Xtro\six4
1 of 13
No
No
Xtro\tm9sf1
1 of 13
No
No
Xtro\tmem143
1 of 13
No
No
Xtro\uncx
1 of 13
No
No
Xtro\ventx1.1
1 of 13
No
No
Xtro\ventx1.2
1 of 13
No
No
Xtro\ventx2.1
1 of 13
No
No
Xtro\ventx2.2
1 of 13
No
No
Xtro\ventx3.2
1 of 13
No
No
Xtro\vsx2
1 of 13
No
No
Danio rerio (Zebrafish) (94)
Drer\barhl1b
10 of 14
Yes
Yes
Drer\barhl1a
9 of 14
No
Yes
Drer\barhl2
7 of 14
No
No
Drer\barx1
4 of 14
No
Yes
Drer\barx2
3 of 14
No
No
Drer\dbx1a
2 of 14
No
No
Drer\dbx1b
2 of 14
No
No
Drer\lbx2
2 of 14
No
No
Drer\tlx2
2 of 14
No
No
Drer\tlx3b
2 of 14
No
No
Drer\arxa
1 of 14
No
No
Drer\arxb
1 of 14
No
No
Drer\bsx
1 of 14
No
No
Drer\dlx1a
1 of 14
No
No
Drer\dlx2a
1 of 14
No
No
Drer\dlx2b
1 of 14
No
No
Drer\dlx3b
1 of 14
No
No
Drer\dlx4a
1 of 14
No
No
Drer\dlx4b
1 of 14
No
No
Drer\dlx5a
1 of 14
No
No
Drer\dlx6a
1 of 14
No
No
Drer\dmbx1b
1 of 14
No
No
Drer\emx2
1 of 14
No
No
Drer\gbx1
1 of 14
No
No
Drer\gbx2
1 of 14
No
No
Drer\gsc
1 of 14
No
No
Drer\gsx2
1 of 14
No
No
Drer\hlx1
1 of 14
No
No
Drer\hmx1
1 of 14
No
No
Drer\hmx2
1 of 14
No
No
Drer\hmx3a
1 of 14
No
No
Drer\hmx3b
1 of 14
No
No
Drer\hmx4
1 of 14
No
No
Drer\hoxa3a
1 of 14
No
No
Drer\hoxa4a
1 of 14
No
No
Drer\hoxa9b
1 of 14
No
No
Drer\hoxa11b
1 of 14
No
No
Drer\hoxb2a
1 of 14
No
No
Drer\hoxb4a
1 of 14
No
No
Drer\hoxb5a
1 of 14
No
No
Drer\hoxb5b
1 of 14
No
No
Drer\hoxb6b
1 of 14
No
No
Drer\hoxb9a
1 of 14
No
No
Drer\hoxc3a
1 of 14
No
No
Drer\hoxc4a
1 of 14
No
No
Drer\hoxc11b
1 of 14
No
No
Drer\hoxd4a
1 of 14
No
No
Drer\hoxd10a
1 of 14
No
No
Drer\lbx1a
1 of 14
No
No
Drer\lbx1b
1 of 14
No
No
Drer\lhx8a
1 of 14
No
No
Drer\LOC100008066
1 of 14
No
No
Drer\mnx1
1 of 14
No
No
Drer\mnx2a
1 of 14
No
No
Drer\mnx2b
1 of 14
No
No
Drer\msx1a
1 of 14
No
No
Drer\msx1b
1 of 14
No
No
Drer\msx2a
1 of 14
No
No
Drer\msx2b
1 of 14
No
No
Drer\msx3
1 of 14
No
No
Drer\nkx1.2la
1 of 14
No
No
Drer\nkx2.1
1 of 14
No
No
Drer\nkx2.2a
1 of 14
No
No
Drer\nkx2.2b
1 of 14
No
No
Drer\nkx2.3
1 of 14
No
No
Drer\nkx2.4a
1 of 14
No
No
Drer\nkx2.4b
1 of 14
No
No
Drer\nkx2.5
1 of 14
No
No
Drer\nkx2.7
1 of 14
No
No
Drer\nkx3-1
1 of 14
No
No
Drer\nkx3-2
1 of 14
No
No
Drer\nkx6.1
1 of 14
No
No
1  
Drer\nkx6.2
1 of 14
No
No
Drer\noto
1 of 14
No
No
Drer\npm1b
1 of 14
No
No
Drer\pax3b
1 of 14
No
No
Drer\pax7a
1 of 14
No
No
Drer\pax7b
1 of 14
No
No
Drer\phox2bb
1 of 14
No
No
Drer\pnx
1 of 14
No
No
Drer\rx1
1 of 14
No
No
Drer\rx2
1 of 14
No
No
Drer\shox2
1 of 14
No
No
Drer\shox
1 of 14
No
No
Drer\six4a
1 of 14
No
No
Drer\six4b
1 of 14
No
No
Drer\six5
1 of 14
No
No
Drer\tlx1
1 of 14
No
No
Drer\uncx
1 of 14
No
No
Drer\ved
1 of 14
No
No
Drer\vent
1 of 14
No
No
Drer\vox
1 of 14
No
No
Drer\vsx1
1 of 14
No
No
Drer\vsx2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (37)
Cele\ceh-30
8 of 14
Yes
Yes
Cele\ceh-31
7 of 14
No
No
Cele\ceh-1
2 of 14
No
No
Cele\alr-1
1 of 14
No
No
Cele\ceh-2
1 of 14
No
No
Cele\ceh-5
1 of 14
No
No
Cele\ceh-9
1 of 14
No
No
Cele\ceh-10
1 of 14
No
No
Cele\ceh-12
1 of 14
No
No
Cele\ceh-13
1 of 14
No
No
0  
Cele\ceh-16
1 of 14
No
No
Cele\ceh-17
1 of 14
No
No
Cele\ceh-19
1 of 14
No
No
Cele\ceh-23
1 of 14
No
No
Cele\ceh-24
1 of 14
No
No
Cele\ceh-27
1 of 14
No
No
Cele\ceh-28
1 of 14
No
No
Cele\ceh-43
1 of 14
No
No
Cele\ceh-45
1 of 14
No
No
Cele\ceh-51
1 of 14
No
No
Cele\ceh-54
1 of 14
No
No
Cele\ceh-62
1 of 14
No
No
Cele\cog-1
1 of 14
No
No
Cele\lim-4
1 of 14
No
No
Cele\lin-39
1 of 14
No
No
Cele\mab-5
1 of 14
No
No
Cele\mls-2
1 of 14
No
No
Cele\pha-2
1 of 14
No
No
Cele\php-3
1 of 14
No
No
Cele\tab-1
1 of 14
No
No
Cele\ttx-3
1 of 14
No
No
Cele\unc-4
1 of 14
No
No
Cele\unc-30
1 of 14
No
No
Cele\unc-42
1 of 14
No
No
Cele\vab-3
1 of 14
No
No
Cele\vab-7
1 of 14
No
No
1  
Cele\vab-15
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (45)
Agam\AgaP_AGAP012428
5 of 12
Yes
No
Agam\AgaP_AGAP005281
3 of 12
No
No
Agam\AgaP_AGAP013373
3 of 12
No
No
Agam\HMEN_ANOGA
3 of 12
No
No
Agam\AgaP_AGAP000484
2 of 12
No
No
Agam\AgaP_AGAP000488
2 of 12
No
No
Agam\AgaP_AGAP001593
2 of 12
No
No
Agam\AgaP_AGAP002372
2 of 12
No
No
Agam\AgaP_AGAP003670
2 of 12
No
No
Agam\AgaP_AGAP003671
2 of 12
No
No
Agam\AgaP_AGAP003672
2 of 12
No
No
Agam\AgaP_AGAP003674
2 of 12
No
No
Agam\AgaP_AGAP004646
2 of 12
No
No
Agam\AgaP_AGAP004647
2 of 12
No
No
Agam\AgaP_AGAP004648
2 of 12
No
No
Agam\AgaP_AGAP005041
2 of 12
No
No
Agam\AgaP_AGAP005346
2 of 12
No
No
Agam\AgaP_AGAP006923
2 of 12
No
No
Agam\AgaP_AGAP009302
2 of 12
No
No
Agam\AgaP_AGAP011253
2 of 12
No
No
Agam\AgaP_AGAP012001
2 of 12
No
No
Agam\AgaP_AGAP013157
2 of 12
No
No
Agam\ABDA_ANOGA
1 of 12
No
No
Agam\AgaP_AGAP000190
1 of 12
No
No
Agam\AgaP_AGAP000858
1 of 12
No
No
Agam\AgaP_AGAP001187
1 of 12
No
No
Agam\AgaP_AGAP001389
1 of 12
No
No
Agam\AgaP_AGAP001483
1 of 12
No
No
Agam\AgaP_AGAP001618
1 of 12
No
No
Agam\AgaP_AGAP001619
1 of 12
No
No
Agam\AgaP_AGAP003669
1 of 12
No
No
Agam\AgaP_AGAP004659
1 of 12
No
No
Agam\AgaP_AGAP004660
1 of 12
No
No
Agam\AgaP_AGAP004661
1 of 12
No
No
Agam\AgaP_AGAP005096
1 of 12
No
No
Agam\AgaP_AGAP005099
1 of 12
No
No
Agam\AgaP_AGAP005311
1 of 12
No
No
Agam\AgaP_AGAP005727
1 of 12
No
No
Agam\AgaP_AGAP007058
1 of 12
No
No
Agam\AgaP_AGAP007985
1 of 12
No
No
Agam\AgaP_AGAP009646
1 of 12
No
No
Agam\AgaP_AGAP010279
1 of 12
No
No
Agam\AgaP_AGAP011417
1 of 12
No
No
Agam\AgaP_AGAP013075
1 of 12
No
No
Agam\EXD_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (46)
Atha\ATHB13
2 of 13
Yes
No
Atha\AtHB23
2 of 13
Yes
No
Atha\ATHB54
2 of 13
Yes
No
Atha\HAT1
2 of 13
Yes
No
Atha\HAT2
2 of 13
Yes
No
Atha\HAT3
2 of 13
Yes
No
Atha\HAT9
2 of 13
Yes
No
Atha\HAT14
2 of 13
Yes
No
Atha\HAT22
2 of 13
Yes
No
Atha\HB-1
2 of 13
Yes
No
Atha\HB-2
2 of 13
Yes
No
Atha\HB-3
2 of 13
Yes
No
Atha\HB4
2 of 13
Yes
No
Atha\HB5
2 of 13
Yes
No
Atha\HB6
2 of 13
Yes
No
Atha\HB-7
2 of 13
Yes
No
Atha\HB-12
2 of 13
Yes
No
Atha\HB16
2 of 13
Yes
No
Atha\HB17
2 of 13
Yes
No
Atha\HB18
2 of 13
Yes
No
Atha\HB20
2 of 13
Yes
No
Atha\HB22
2 of 13
Yes
No
Atha\HB51
2 of 13
Yes
No
Atha\HB52
2 of 13
Yes
No
Atha\ANL2
1 of 13
No
No
Atha\AT4G03250
1 of 13
No
No
Atha\ATHB-15
1 of 13
No
Yes
Atha\ATML1
1 of 13
No
No
Atha\FWA
1 of 13
No
No
Atha\GL2
1 of 13
No
No
Atha\HB-7
1 of 13
No
No
Atha\HB-8
1 of 13
No
No
Atha\HB21
1 of 13
No
No
Atha\HB40
1 of 13
No
No
Atha\HB53
1 of 13
No
No
Atha\HDG1
1 of 13
No
No
Atha\HDG2
1 of 13
No
No
Atha\HDG3
1 of 13
No
No
Atha\HDG4
1 of 13
No
No
Atha\HDG9
1 of 13
No
No
Atha\HDG11
1 of 13
No
No
Atha\HDG12
1 of 13
No
No
Atha\PDF2
1 of 13
No
No
Atha\PHB
1 of 13
No
No
Atha\PHV
1 of 13
No
No
Atha\REV
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\YHP1
1 of 13
Yes
No
Scer\YOX1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\phx1
1 of 12
Yes
No
Spom\yox1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:B-H2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (79)
B-H1
9 of 13
CG11085
4 of 13
Dbx
4 of 13
H2.0
4 of 13
slou
4 of 13
bap
3 of 13
bsh
3 of 13
btn
3 of 13
C15
3 of 13
CG18599
3 of 13
CG34031
3 of 13
Dfd
3 of 13
Dr
3 of 13
E5
3 of 13
ems
3 of 13
en
3 of 13
eve
3 of 13
exex
3 of 13
ftz
3 of 13
HGTX
3 of 13
HHEX
3 of 13
Hmx
3 of 13
lbe
3 of 13
lms
3 of 13
NK7.1
3 of 13
pb
3 of 13
tin
3 of 13
unpg
3 of 13
zen
3 of 13
abd-A
2 of 13
al
2 of 13
Antp
2 of 13
cad
2 of 13
CG9876
2 of 13
CG15696
2 of 13
CG34367
2 of 13
Dll
2 of 13
ey
2 of 13
eyg
2 of 13
gsb
2 of 13
gsb-n
2 of 13
hbn
2 of 13
inv
2 of 13
lab
2 of 13
lbl
2 of 13
OdsH
2 of 13
otp
2 of 13
PHDP
2 of 13
Pph13
2 of 13
prd
2 of 13
Ptx1
2 of 13
ro
2 of 13
Rx
2 of 13
scro
2 of 13
toe
2 of 13
toy
2 of 13
Ubx
2 of 13
unc-4
2 of 13
zen2
2 of 13
Abd-B
1 of 13
bcd
1 of 13
CG11294
1 of 13
CG32532
1 of 13
Drgx
1 of 13
exd
1 of 13
Gsc
1 of 13
ind
1 of 13
Lim1
1 of 13
Lim3
1 of 13
Lmx1a
1 of 13
oc
1 of 13
repo
1 of 13
Scr
1 of 13
Six4
1 of 13
tup
1 of 13
vnd
1 of 13
Vsx1
1 of 13
Vsx2
1 of 13
vvl
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BARHL1; BarH like homeobox 1
    10 of 14
    605211
        BARHL2; BarH like homeobox 2
        9 of 14
        605212
            BARX1; BARX homeobox 1
            4 of 14
            603260
                BARX2; BARX homeobox 2
                4 of 14
                604823
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    Interaction Browsers
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    External Data
                    Linkouts
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    X
                    Recombination map
                    1-57
                    Cytogenetic map
                    16A1-16A1
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    16A1-16A1
                    Limits computationally determined from genome sequence between P{EP}bazEP1446 and P{EP}EP1464
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    15F9-16A1
                    (determined by in situ hybridisation)
                    (Higashijima et al., 1992)
                    Experimentally Determined Recombination Data
                    Location

                    1-57

                    (FlyBase, 2016)

                    1-57.7

                    (Comeron et al., 2012)

                    1-56.7

                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (30)
                    Genomic Clones (19)
                    cDNA Clones (18)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Higashijima et al., 1992)
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                          (Boutros et al., 2004)

                          B-H1 and B-H2 are functionally redundant and are essential for distal leg morphogenesis.

                          (Kojima et al., 2000)

                          B-H1 and B-H2 regulate the formation of microchaetae via activation of ac and sc. B-H1 and B-H2 is limited dorsally and posteriorly by dpp and ventrally by wg which is in turn regulated by dpp. In direction of increasing cytology: f? Fim? B-H2+ B-H1+ anon-X2?

                          (Sato et al., 1999)

                          B-H1 and B-H2 may belong to a different class of prepattern genes expressed latitudinally, giving a different coordinate to the prepattern in the developing notum. They are required for the formation of notal microchaetae and presutural macrochaetae.

                          (Sato et al., 1999)

                          B-H1 and B-H2 are expressed only in embryogenesis and metamorphosis. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 prephotoreceptor cells and anterior and posterior primary pigment cells for normal eye development.

                          (Higashijima et al., 1992)

                          B and B-H2 are paired homeotic genes required for the fate determination of es organs. Immunostaining demonstrated that B and B-H2 proteins are coexpressed in embryonic CNS and PNS cells. Deletion of the entire bar region causes morphological changes in the complex es organs and partial conversion of the simple es organs from campaniform-like sensilla to trichoid sensilla.

                          (Higashijima et al., 1992)

                          This study raises the possibilty that B-H1, not B, is the Bar gene and that more than one gene may be involved in Bar position effects.

                          (Norris et al., 1992)
                          Relationship to Other Genes
                          Source for database merge of
                          Additional comments

                          Dp(1;3)DC328 (which encompasses B-H2 but not B-H1) does not exhibit a Bar phenotype.

                          (Venken et al., 2010)
                          Nomenclature History
                          Source for database identify of
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (10)
                          Reported As
                          Symbol Synonym
                          B
                          (Pueyo et al., 2000)
                          B-H2
                          (Bravo González-Blas et al., 2023, Ray et al., 2022, McLaughlin et al., 2021, Shokri et al., 2019, Bischof et al., 2018, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Li et al., 2016, Miller et al., 2016, Schertel et al., 2015, Slattery et al., 2013, Reis et al., 2010, Garces et al., 2006, Copley, 2005, Hoskins et al., 2005)
                          BH2
                          (Buffry et al., 2023, Ringrose et al., 2004)
                          Bar
                          (Greenberg and Hatini, 2009, Lim and Choi, 2004, Fan et al., 2003, Pazman et al., 2000, Sawamoto et al., 1999)
                          Bar-H2
                          (Freeman, 1997)
                          BarH
                          (Lacin et al., 2014)
                          BarH2
                          (Doe and Thor, 2024, Ariss et al., 2018, Kojima, 2017, Bürglin and Affolter, 2016, Bao and Friedrich, 2009, Apitz et al., 2005)
                          Barh2
                          (Garces et al., 2006)
                          CG5488
                          (Bel et al., 2011, Ni et al., 2010.12.1)
                          bar-h2
                          (Parrish et al., 2007)
                          Name Synonyms
                          Bar
                          (Sakurai et al., 2007, Kozu et al., 2006)
                          BarH2
                          (Del Signore et al., 2012, Bel et al., 2011, Venken et al., 2010, Reig et al., 2007, Sakurai et al., 2007, Tajiri et al., 2007, Yasunaga et al., 2006, Voas and Rebay, 2004, Kumar and Moses, 2001, Kumar and Moses, 2001, Brennan and Moses, 2000, Hayashi and Saigo, 2000, Kojima et al., 2000, Kojima et al., 1999, Mandal and Lakhotia, 1999, Sato et al., 1999, Sato et al., 1999, Hayashi et al., 1998, Saito et al., 1998, Sato et al., 1998, Fu and Noll, 1997, Choi et al., 1996, Kramer et al., 1995, Jan and Jan, 1994, Kramer and Cagan, 1994, Ghysen and Dambly-Chaudiere, 1993, Hiromi et al., 1993, Jan and Jan, 1993, Jimenez and Modolell, 1993, Kojima et al., 1993, Higashijima, 1992.5.28, Higashijima, 1992.5.28, Higashijima, 1992.5.28, Higashijima, 1992.5.28, Higashijima et al., 1992)
                          Secondary FlyBase IDs
                            Datasets (0)
                            Study focus (0)
                            Experimental Role
                            Project
                            Project Type
                            Title
                            Study result (0)
                            Result
                            Result Type
                            Title
                            External Crossreferences and Linkouts ( 38 )
                            Sequence Crossreferences
                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                            Other crossreferences
                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                            FlyMine - An integrated database for Drosophila genomics
                            InterPro - A database of protein families, domains and functional sites
                            KEGG Genes - Molecular building blocks of life in the genomic space.
                            MARRVEL_MODEL - MARRVEL (model organism gene)
                            Linkouts
                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                            DroID - A comprehensive database of gene and protein interactions.
                            DRSC - Results frm RNAi screens
                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                            Flygut - An atlas of the Drosophila adult midgut
                            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            References (125)