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General Information
Symbol
Dmel\orb
Species
D. melanogaster
Name
oo18 RNA-binding protein
Annotation Symbol
CG10868
Feature Type
FlyBase ID
FBgn0004882
Gene Model Status
Stock Availability
Gene Summary
oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)
Also Known As

Orb1, oo18

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-78
RefSeq locus
NT_033777 REGION:23260610..23280856
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:bru1; FB:FBgn0000114
inferred from physical interaction with FLYBASE:BicC; FB:FBgn0000182
inferred from physical interaction with UniProtKB:Q9VYS4
(assigned by UniProt )
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
enables mRNA binding
inferred from sequence or structural similarity
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:rin; FB:FBgn0015778
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
Cellular Component (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
located_in cytoplasm
inferred from direct assay
inferred from physical interaction with FLYBASE:rin; FB:FBgn0015778
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
is_active_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
is_active_in synapse
inferred from biological aspect of ancestor with PANTHER:PTN000286163
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Snapshot
oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation. [Date last reviewed: 2019-09-19]
Summary (Interactive Fly)

RRM - RNA binding protein - Drosophila's cytoplasmic polyadenylation element binding protein (CPEB) - functions in the transport of mRNAs coding for two essential proteins that govern polarity in the egg: Oskar, an anterior/posterior determinate and Gurken, a dorsal/ventral determinant

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\orb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Striking stage and tissue-specific differences in 3' UTR extent apparent in RNA-seq expression profile data.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0084384
4862
915
FBtr0084385
4251
913
FBtr0084386
2957
559
FBtr0100227
3258
913
FBtr0100228
1964
559
FBtr0301491
3079
617
FBtr0334498
8899
915
Additional Transcript Data and Comments
Reported size (kB)

4.7, 3.2, 2.0 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083776
98.7
915
8.04
FBpp0083777
97.7
913
7.56
FBpp0083778
62.7
559
9.59
FBpp0099606
97.7
913
7.56
FBpp0099607
62.7
559
9.59
FBpp0290706
69.0
617
9.03
FBpp0306565
98.7
915
8.04
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

915 aa isoforms: orb-PA, orb-PG
559 aa isoforms: orb-PC, orb-PE
913 aa isoforms: orb-PB, orb-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

915, 913 (aa); 99 (kD predicted)

Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\orb using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

orb transcripts are detected at low levels in primary spermatocytes and are barely detected in early elongation spermatids. Robust signals are detected in more elongated spermatids at the distal ends. Transcripts localize in shallow cup-like shapes at the ends of spermatids bundles (called a cup pattern).

orb expression at embryonic stages 1-4 is localized to the posterior pole of the embryo. At embryonic stage 3, orb transcript forms rings around the pole cell nuclei.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

High levels of orb are found in the tips of elongated spermatids that have neither orb2 nor dj.

orb protein is detected in the female ovary. At oogenesis stages S8 to S10, orb protein is enriched in the cortex of the oocyte, similar to orb2 protein.

orb expression starts in all cystocytes between the 8- and 16- cell stage but is restricted to the oocyte in later stages.

orb protein is first observed in the cytoplasm of the oocyte and several adjacent cells in germarium region 2a just after the completion of premeiotic S-phase.

orb protein expression is restricted to the germline during oogenesis. Significant levels of orb protein are first seen in the 16-cell stage in germarium region 2. Protein is observed in all cells of the cyst but begins to preferentially localize in the presumptive oocyte. By stage S7, it is concentrated at the posterior edge of the oocyte. Unlike the RNA, orb protein is distributed along the entire cortex of the oocyte in stages S8-S10. Graded expression is also observed in nurse cells with the highest levels in the nurse cells closest to the oocyte.

Marker for
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
located_in cytoplasm
inferred from direct assay
inferred from physical interaction with FLYBASE:rin; FB:FBgn0015778
Expression Deduced from Reporters
Reporter: P{GawB}orbNP1612
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\orb in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 30 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of orb
Transgenic constructs containing regulatory region of orb
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
2 of 15
No
No
0  
2 of 15
No
No
2 of 15
No
No
Rattus norvegicus (Norway rat) (3)
6 of 13
Yes
Yes
2 of 13
No
No
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
6 of 12
Yes
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (7)
8 of 15
Yes
Yes
7 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
9 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904WE )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915055L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W050R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06XT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0AO9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
3 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-78
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    94E9-94E9
    Limits computationally determined from genome sequence between P{PZ}cnc03921 and P{PZ}l(3)0690606906
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    94E1-94E10
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (20)
    cDNA Clones (98)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: orb CG10868

    Source for database merge of
    Additional comments
    Other Comments

    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    Identification: in a germline clone screen for mutants that are defective in localisation of an Avic\GFP-stau marker in living oocytes. 4 alleles of orb have been identified in the screen.

    orb functions in both early and late grk-Egfr signalling pathways, and in each case is required for the localised expression of grk protein.

    orb protein autoregulates its own expression through sequences in the 3'UTR of the orb mRNA.

    All of the cells in the female germline cyst form synaptonemal complex in orb mutants.

    orb is required for osk protein expression in oocytes.

    The predicted orb protein contains two RRM type RNA-binding domains and it is localised in a subcortical network within the oocyte. orb may be involved in the regulation of translation.

    Anterior localisation of RNA during oogenesis is very sensitive to microtubule inhibitors, taxol and other microtubule depolymerising agents. These results, together with colchicine treatment studies, demonstrate that microtubules are required for RNA transport to the oocyte.

    Mutant analysis suggests that orb is required for A/P axis formation and D/V patterning.

    280bp sequence from the orb 3' untranslated region is capable of reproducing orb mRNA complex localisation pattern during oogenesis. Multiple cis-acting elements appear to be required for proper targeting of orb mRNA.

    Distribution of orb protein in wild type and mutant ovaries has been studies using antibodies.

    orb has been isolated and characterised, it encodes female- and male-specific protein products containing two putative RNA-binding domains.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 83 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL - MARRVEL (model organism gene)
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (14)
    Reported As
    Symbol Synonym
    Orb
    (Lu et al., 2021, Bansal et al., 2020, Dold et al., 2020, Gonzalez et al., 2020, Olesnicky and Killian, 2020, Rust et al., 2020, Sankaranarayanan and Weil, 2020, Barr et al., 2019, Broyer et al., 2017, Lou et al., 2017, Kanke et al., 2015, Lake et al., 2015, Liu and Lasko, 2015, Hamada-Kawaguchi et al., 2014, Hayashi et al., 2014, Li et al., 2014, Minakhina et al., 2014, Sitaram et al., 2014, Barckmann and Simonelig, 2013, Hernández et al., 2013, Iovino et al., 2013, Jagut et al., 2013, Leibfried et al., 2013, Ohtani et al., 2013, Anand and Kai, 2012, Baffet et al., 2012, Ferguson et al., 2012, Hayashi et al., 2012, Nagel et al., 2012, Rincon-Arano et al., 2012, Rojas-Ríos et al., 2012, Siddiqui et al., 2012, Smibert et al., 2012, Xu and Gridley, 2012, Hafer et al., 2011, Hongay and Orr-Weaver, 2011, Morawe et al., 2011, Senger et al., 2011, Xu et al., 2011, Becalska and Gavis, 2010, Doerflinger et al., 2010, Fichelson et al., 2010, Gandille et al., 2010, Kugler et al., 2010, Ong et al., 2010, Orsi et al., 2010, Tastan et al., 2010, Yu et al., 2010, Aruna et al., 2009, Besse et al., 2009, Fichelson et al., 2009, Gates et al., 2009, Kim et al., 2009, Mirouse et al., 2009, Mirouse et al., 2009, Narbonne-Reveau and Lilly, 2009, Navarro et al., 2009, Ozdowski et al., 2009, Snee and Macdonald, 2009, Yatsenko et al., 2009, Benoit et al., 2008, Bosveld et al., 2008, Boylan et al., 2008, Gervais et al., 2008, Lee et al., 2008, Neumuller et al., 2008, Assa-Kunik et al., 2007, Bogard et al., 2007, Clough et al., 2007, Kimble and Page, 2007, Lake et al., 2007, Maines et al., 2007, Malmanche et al., 2007, Nurminsky, 2007, Parma et al., 2007, Penn and Schedl, 2007, Stevens et al., 2007, Wong et al., 2007, Yatsenko et al., 2007, Deshpande et al., 2006, Hafer and Schedl, 2006, Jenny et al., 2006, Lin et al., 2006, McCaffrey et al., 2006, McCaffrey et al., 2006, O'Reilly et al., 2006, Wehr et al., 2006, Becam et al., 2005, Cohen et al., 2005, Gong et al., 2005, Costa et al., 2004, Navarro et al., 2004, Jang et al., 2003, Deng et al., 2002, Cox et al., 2001, Glenn and Searles, 2001, Bhat and Schedl, 1997)
    fs(3)00107
    oo18 RNA-binding protein
    orb
    (Connacher and Goldstrohm, 2021, Diegmiller et al., 2021, Hinnant et al., 2020, Kankel et al., 2020, Ote and Yamamoto, 2020, Trcek et al., 2020, Fingerhut et al., 2019, Rivera et al., 2019, Whittle and Extavour, 2019, Olesnicky et al., 2018, Derrick and Weil, 2017, Vazquez-Pianzola et al., 2017, Clandinin and Owens, 2016-, Davidson et al., 2016, Kong et al., 2016, Na et al., 2016, Chartier et al., 2015, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Olesnicky et al., 2014, Vazquez-Pianzola et al., 2014, Costa et al., 2013, de Celis et al., 2013.9.11, Laver et al., 2013, Xin et al., 2013, Azzam et al., 2012, Caldeira et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ji and Tulin, 2012, Li et al., 2012, Smibert et al., 2012, Xu and Gridley, 2012, Xu et al., 2012, Di Stefano et al., 2011, Dubin-Bar et al., 2011, Vazquez-Pianzola et al., 2011, Wong et al., 2011, Lewandowski et al., 2010, Reveal et al., 2010, Rangan et al., 2009, Barreau et al., 2008, Bushati et al., 2008, FlyBase Curators, 2008-, Li et al., 2008, Rangan et al., 2008, Chicoine et al., 2007, Geng and MacDonald, 2007, Kankel et al., 2007, Lecuyer et al., 2007, Pesin and Orr-Weaver, 2007, Roper, 2007, Stark et al., 2007, Tadros et al., 2007, Vardy and Orr-Weaver, 2007, Molnar et al., 2006, Narbonne-Reveau et al., 2006, Tsuda et al., 2006, Vogt et al., 2006, Benoit et al., 2005, Cho et al., 2005, Costa et al., 2005, Xie et al., 2005, Motola and Neuman-Silberberg, 2004, Ranz et al., 2004, Gim et al., 2001)
    Secondary FlyBase IDs
      Datasets (0)
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