FB2020_06, released Dec 22, 2020

Gene: Dmel\Arl2

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General Information
Symbol
Dmel\Arl2
Species
D. melanogaster
Name
ADP ribosylation factor-like 2
Annotation Symbol
CG7435
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004908
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
ADP ribosylation factor-like 2 (Arl2) encodes a small GTPase within the ADP-ribosylation factor-like family. Arl2 product functions as a central regulator of microtubule growth and asymmetric division of neuroblasts. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As

Arf84F, Arl84F, Q06849

Key Links
Genomic Location
Cytogenetic map
84F13-84F13
Sequence location
3R:8,341,100..8,341,872 [+]
Recombination map

3-48

RefSeq locus
NT_033777 REGION:8341100..8341872
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN002904794
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:693
(Clark et al., 1993)
inferred from sequence model
(Clark et al., 1993)
enables GTPase activity
inferred from sequence or structural similarity with UniProtKB:P36404
(FlyBase Curators, 2008--)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in establishment of mitotic spindle orientation
inferred from mutant phenotype
(Chen et al., 2016)
involved_in establishment or maintenance of neuroblast polarity
inferred from mutant phenotype
(Chen et al., 2016)
involved_in microtubule cytoskeleton organization involved in mitosis
inferred from mutant phenotype
(Chen et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in neurotransmitter secretion
traceable author statement
(Lloyd et al., 2000)
involved_in positive regulation of microtubule polymerization
inferred from biological aspect of ancestor with PANTHER:PTN000195421
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in synaptic vesicle endocytosis
traceable author statement
(Lloyd et al., 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002904794
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in microtubule cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN002904794
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Arf family. (Q06849)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ARF GTPASES -
The ADP-Ribosylation Factor (Arf) family are members of the Ras superfamily of small GTPases. Arfs are involved in the regulation of vesicular trafficking mediating processes such as cargo-sorting, vesicle assembly and membrane fusion. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
(UniProt, Q06849)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Arl2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Arl2-RA
FBtr0081838
NM_057538
656
184
Additional Transcript Data and Comments
Reported size (kB)

0.8 (northern blot)

(Clark et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Arl2-PA
FBpp0081328
20.8
184
6.12
NP_476886
AAF54228
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

184 (aa)

(Clark et al., 1993)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arl2 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Clark et al., 1993)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Chen et al., 2016)
third instar larval stage
embryonic/larval gut
(Chen et al., 2016)
embryonic/larval brain
(Chen et al., 2016)
adult stage
adult head
(Chen et al., 2016)
Additional Descriptive Data

Arl2 transcripts are detected in embryonic, larval, pupal, and adult stages.

(Clark et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Arl2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Arl2
Transgenic constructs containing regulatory region of Arl2
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal - all die during embryonic stage
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
decreased cell number | third instar larval stage, with Scer\GAL4ase.neuro
decreased cell number | third instar larval stage, with Scer\GAL4insc.PU
decreased cell number | third instar larval stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
developmental rate defective | larval stage, with Arl2T30N.UAS, Scer\GAL4insc.PU
developmental rate defective | larval stage, with Arl2Δ156, Scer\GAL4insc.PU
increased cell number | somatic clone | third instar larval stage
increased cell number | somatic clone | third instar larval stage, with Scer\GAL4ase.neuro
increased cell number | somatic clone | third instar larval stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
increased cell number | third instar larval stage, with Arl2T30N.UAS, Scer\GAL4insc.PU
increased cell number | third instar larval stage, with Arl2Δ156, Scer\GAL4insc.PU
increased cell number | third instar larval stage, with Scer\GAL4insc.PU
mitotic cell cycle defective | somatic clone | third instar larval stage
mitotic cell cycle defective | third instar larval stage
mitotic cell cycle defective | third instar larval stage, with Arl2T30N.UAS, Scer\GAL4insc.PU
mitotic cell cycle defective | third instar larval stage, with Arl2Δ156, Scer\GAL4insc.PU
mitotic cell cycle defective | third instar larval stage, with Scer\GAL4insc.PU
neuroanatomy defective | larval stage
neuroanatomy defective | somatic clone | third instar larval stage
neuroanatomy defective | third instar larval stage, with Arl2T30N.UAS, Scer\GAL4insc.PU
neuroanatomy defective | third instar larval stage, with Arl2Δ156, Scer\GAL4insc.PU
neuroanatomy defective | third instar larval stage, with Scer\GAL4insc.PU
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
aster | somatic clone | third instar larval stage
aster | third instar larval stage
centrosome | third instar larval stage, with Scer\GAL4insc.PU
ganglion mother cell | larval stage
larval neuroblast | larval stage
larval neuroblast | somatic clone | supernumerary | third instar larval stage
larval neuroblast | somatic clone | supernumerary | third instar larval stage, with Scer\GAL4ase.neuro
larval neuroblast | somatic clone | supernumerary | third instar larval stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
larval neuroblast | supernumerary | third instar larval stage, with Arl2T30N.UAS, Scer\GAL4insc.PU
larval neuroblast | supernumerary | third instar larval stage, with Arl2Δ156, Scer\GAL4insc.PU
larval neuroblast | supernumerary | third instar larval stage, with Scer\GAL4insc.PU
larval neuroblast | third instar larval stage
larval neuroblast | third instar larval stage, with Scer\GAL4insc.PU
microtubule | third instar larval stage, with Scer\GAL4insc.PU
spindle | somatic clone | third instar larval stage
spindle | third instar larval stage
spindle | third instar larval stage, with Arl2T30N.UAS, Scer\GAL4insc.PU
spindle | third instar larval stage, with Arl2Δ156, Scer\GAL4insc.PU
spindle | third instar larval stage, with Scer\GAL4insc.PU
trichogen cell, with Scer\GAL4pnr-MD237
type II neuroblast | somatic clone | third instar larval stage
type II neuroblast | somatic clone | third instar larval stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
type II neuroblast | third instar larval stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
type I neuroblast | somatic clone | third instar larval stage
type I neuroblast | somatic clone | third instar larval stage, with Scer\GAL4ase.neuro
type I neuroblast | third instar larval stage, with Scer\GAL4ase.neuro
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ARL2
14 of 15
Yes
Yes
Hsap\ARL2-SNX15
2 of 15
No
Yes
Hsap\ARFRP1
1 of 15
No
No
Hsap\ARL1
1 of 15
No
No
Hsap\ARL3
1 of 15
No
No
Hsap\ARL6
1 of 15
No
No
1  
Hsap\ARL13A
1 of 15
No
No
Hsap\ARL14
1 of 15
No
No
Hsap\CYP11B1
1 of 15
No
No
Hsap\NCOA2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Arl2
14 of 15
Yes
Yes
Mmus\Arl3
2 of 15
No
No
Mmus\Arl1
1 of 15
No
No
Mmus\Arl6
1 of 15
No
No
Mmus\Arl11
1 of 15
No
No
Mmus\Arl13a
1 of 15
No
Yes
Mmus\Arl14
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Arl2
13 of 13
Yes
Yes
Rnor\Arl3
2 of 13
No
No
Rnor\Arfrp1
1 of 13
No
No
Rnor\Arl1
1 of 13
No
No
Rnor\Arl6
1 of 13
No
No
Rnor\Arl10
1 of 13
No
Yes
Rnor\Arl11
1 of 13
No
No
Rnor\Arl14
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\arl2
13 of 12
Yes
Yes
Xtro\arl3l2
2 of 12
No
No
Xtro\arl3
2 of 12
No
No
Xtro\arl1
1 of 12
No
No
Xtro\arl6
1 of 12
No
No
Xtro\arl11
1 of 12
No
No
Xtro\arl11
1 of 12
No
No
Xtro\arl14
1 of 12
No
No
Xtro\LOC100170433
1 of 12
No
Yes
Xtro\LOC101734701
1 of 12
No
Yes
Xtro\LOC101734763
1 of 12
No
Yes
Danio rerio (Zebrafish) (11)
Drer\arl2
10 of 15
Yes
Yes
Drer\arl3a
2 of 15
No
No
Drer\arl3b
2 of 15
No
No
Drer\arl3l1
2 of 15
No
No
Drer\arl3l2
2 of 15
No
No
Drer\arfrp1
1 of 15
No
No
Drer\arl1
1 of 15
No
No
Drer\arl6
1 of 15
No
No
Drer\arl11
1 of 15
No
No
Drer\arl14
1 of 15
No
No
Drer\npm3
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\evl-20
14 of 15
Yes
Yes
Cele\arl-1
1 of 15
No
No
Cele\arl-3
1 of 15
No
No
Cele\arl-6
1 of 15
No
No
Cele\Y54E10BR.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (7)
Atha\TTN5
8 of 9
Yes
Yes
Atha\ARF3
1 of 9
No
No
Atha\ARFB1B
1 of 9
No
Yes
Atha\ARFB1C
1 of 9
No
Yes
Atha\ARFD1A
1 of 9
No
Yes
Atha\ARFD1B
1 of 9
No
Yes
Atha\GB1
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CIN4
7 of 15
Yes
Yes
Scer\ARL3
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\alp41
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GA1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010626
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010199
Drosophila simulans
Dsim\GD18536
Drosophila sechellia
Dsec\GM23726
Drosophila erecta
Dere\GG10035
Drosophila yakuba
Dyak\GE25871
Drosophila ananassae
Dana\GF18345
Drosophila pseudoobscura pseudoobscura
Dpse\GA20349
Drosophila persimilis
Dper\GL23431
Drosophila willistoni
Dwil\GK13183
Drosophila virilis
Dvir\GJ24514
Drosophila mojavensis
Dmoj\GI24871
Drosophila grimshawi
Dgri\GH14228
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BXL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016694
Musca domestica
House fly
Mdoa\17012784
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13468
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04314
Mayetiola destructor
Hessian fly
Mdes\Mdes000390
Mayetiola destructor
Hessian fly
Mdes\Mdes000333
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004568
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003281
Anopheles darlingi
American malaria mosquito
Adar\ADAC008314
Anopheles darlingi
American malaria mosquito
Adar\ADAC009377
Anopheles gambiae
Malaria mosquito
Agam\AGAP005267
Anopheles gambiae
Malaria mosquito
Agam\AGAP004496
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001058
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012995
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DPA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000786
Bombyx mori
Silkmoth
Bmor\BGIBMGA000034
Danaus plexippus
Monarch butterfly
Dple\DPOGS212839-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210263-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004483
Heliconius melpomene
Postman butterfly
Hmel\HMEL008623
Apis florea
Little honeybee
Aflo\3824172628
Apis florea
Little honeybee
Aflo\2200188068
Apis mellifera
Western honey bee
Amel\LOC411085
Apis mellifera
Western honey bee
Amel\LOC408522
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16264
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25213
Bombus terrestris
Buff-tailed bumblebee
Bter\15216272
Bombus terrestris
Buff-tailed bumblebee
Bter\15205633
Linepithema humile
Argentine ant
Lhum\LH14125
Linepithema humile
Argentine ant
Lhum\LH18290
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001a0b
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001c86
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011685
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002288
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12504
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12853
Tribolium castaneum
Red flour beetle
Tcas\TC010041
Tribolium castaneum
Red flour beetle
Tcas\TC012465
Pediculus humanus
Human body louse
Phum\PHUM591560
Pediculus humanus
Human body louse
Phum\PHUM461000
Rhodnius prolixus
Kissing bug
Rpro\RPRC004646
Rhodnius prolixus
Kissing bug
Rpro\RPRC004943
Cimex lectularius
Bed bug
Clec\CLEC003056
Cimex lectularius
Bed bug
Clec\CLEC001730
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003701
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006316
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14500
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07168
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FX0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013065
Strigamia maritima
European centipede
Smar\SMAR000806
Ixodes scapularis
Black-legged tick
Isca\ISCW018586
Ixodes scapularis
Black-legged tick
Isca\ISCW023258
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81939.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00440
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02040
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_129159
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_130078
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0O6V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Arl3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Arl2
Ciona intestinalis
Vase tunicate
Cint\LOC100178355
Ciona intestinalis
Vase tunicate
Cint\LOC100176430
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003134
Gallus gallus
Domestic chicken
Ggal\ARL3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
dnd
4 of 10
Arfrp1
2 of 10
Arl1
2 of 10
Arl6
2 of 10
CG11356
2 of 10
Arf51F
1 of 10
Arf79F
1 of 10
Arf102F
1 of 10
Arl4
1 of 10
Arl5
1 of 10
Arl8
1 of 10
CG13692
1 of 10
CG17819
1 of 10
Sar1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ARL2; ADP ribosylation factor like GTPase 2
    14 of 15
    601175
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Arl2
      suppressible
      msps
      (Chen et al., 2016)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      TBCD
      enhanceable
      Arl2
      (Chen et al., 2016)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-48

      Cytogenetic map
      84F13-84F13
      Sequence location
      3R:8,341,100..8,341,872 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      84F13-84F13
      Limits computationally determined from genome sequence between P{EP}EP833 and P{lacW}l(3)L4740L4740
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-48

      (FlyBase, 2016)

      3-44.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (8)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (4)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Arf84F CG7435

      (Zhao, 1999.11)

      Source for identity of: Arl2 Arf84F

      (FlyBase, 2009-)
      Source for database merge of
      Additional comments

      FlyBase curator comment: Renamed 'Arf84F' to 'Arl2' to reflect the 'Arl' (rather than 'Arf') symbol used in original paper (FBrf0064410), the orthology to H. sapiens ARL2, and to match the 'Arl1' symbol format.

      (FlyBase, 2009-)

      Suggested that "nac" may be a mutation in "Arf84F".

      (Clark et al., 1993)
      Other Comments

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)

      Encodes a small GTP-binding protein of the ADP-ribosymation factor family.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 35 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (15)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (58)