FlyBase Gene Report: Dmel\Arl2

General Information

Symbol

Dmel\Arl2

Species

D. melanogaster

Name

ADP ribosylation factor-like 2

Annotation Symbol

CG7435

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004908

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

ADP ribosylation factor-like 2 (Arl2) encodes a small GTPase within the ADP-ribosylation factor-like family. Arl2 product functions as a central regulator of microtubule growth and asymmetric division of neuroblasts. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Arf84F, Arl84F, Q06849

Key Links

Genomic Location

Cytogenetic map

84F13-84F13

Sequence location

3R:8,341,100..8,341,872 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8341100..8341872

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from biological aspect of ancestor with PANTHER:PTN002904794

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:693

(Clark et al., 1993)

inferred from sequence model

(Clark et al., 1993)

enables GTPase activity

inferred from sequence or structural similarity with UniProtKB:P36404

(FlyBase Curators, 2008-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in establishment of mitotic spindle orientation

inferred from mutant phenotype

(Chen et al., 2016)

involved_in establishment or maintenance of neuroblast polarity

inferred from mutant phenotype

(Chen et al., 2016)

involved_in microtubule cytoskeleton organization involved in mitosis

inferred from mutant phenotype

(Chen et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in neurotransmitter secretion

traceable author statement

(Lloyd et al., 2000)

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN000195421

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in synaptic vesicle endocytosis

traceable author statement

(Lloyd et al., 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002904794

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in microtubule cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN002904794

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ARF GTPASES

Protein Family (UniProt)

Belongs to the small GTPase superfamily. Arf family. (Q06849)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ARF GTPASES -: The ADP-Ribosylation Factor (Arf) family are members of the Ras superfamily of small GTPases. Arfs are involved in the regulation of vesicular trafficking mediating processes such as cargo-sorting, vesicle assembly and membrane fusion. (Adapted from PMID:15731001).

Protein Function (UniProtKB)

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

(UniProt, Q06849)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Arl2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q06849)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Arl2-RA

FBtr0081838

NM_057538

656

184

Additional Transcript Data and Comments

Reported size (kB)

0.8 (northern blot)

(Clark et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Arl2-PA

FBpp0081328

20.8

184

6.12

NP_476886

AAF54228

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

184 (aa)

(Clark et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q06849

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arl2 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Clark et al., 1993)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Chen et al., 2016)

third instar larval stage

embryonic/larval gut

(Chen et al., 2016)

embryonic/larval brain

(Chen et al., 2016)

adult stage

adult head

(Chen et al., 2016)

Additional Descriptive Data

Arl2 transcripts are detected in embryonic, larval, pupal, and adult stages.

(Clark et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Arl2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Arl2

View exonic expression by tissue for Dmel\Arl2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40993/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004908

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004908

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004908

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7435

Flygut - An atlas of the Drosophila adult midgut

FBgn0004908

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Arl2

Transgenic constructs containing regulatory region of Arl2

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3R)Arl2^Δ156

(Chen et al., 2016)

Df(3R)Exel6148

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(3R)Arl2^Δ309

(Chen et al., 2016)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Arl2^GD12240

lethal - all die during embryonic stage

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Arl2^GD12240

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Arl2^GD12240

viable, with Scer\GAL4^tin.CΔ4

Arl2^GD12240

Other Phenotypes

Allele

abnormal developmental rate | larval stage, with Arl2^T30N.UAS, Scer\GAL4^insc.PU

Arl2^Δ156

abnormal developmental rate | larval stage, with Arl2^Δ156, Scer\GAL4^insc.PU

Arl2^T30N.UAS

abnormal mitotic cell cycle | somatic clone | third instar larval stage

abnormal mitotic cell cycle | third instar larval stage

Arl2^GS17851

abnormal mitotic cell cycle | third instar larval stage, with Arl2^T30N.UAS, Scer\GAL4^insc.PU

Arl2^Δ156

abnormal mitotic cell cycle | third instar larval stage, with Arl2^Δ156, Scer\GAL4^insc.PU

Arl2^T30N.UAS

abnormal mitotic cell cycle | third instar larval stage, with Scer\GAL4^insc.PU

abnormal neuroanatomy | larval stage

Arl2^GD12240

abnormal neuroanatomy | somatic clone | third instar larval stage

abnormal neuroanatomy | third instar larval stage, with Arl2^T30N.UAS, Scer\GAL4^insc.PU

Arl2^Δ156

abnormal neuroanatomy | third instar larval stage, with Arl2^Δ156, Scer\GAL4^insc.PU

Arl2^T30N.UAS

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^insc.PU

decreased cell number | third instar larval stage, with Scer\GAL4^ase.neuro

Arl2^Q70L.UAS

decreased cell number | third instar larval stage, with Scer\GAL4^insc.PU

Arl2^Q70L.UAS

decreased cell number | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Arl2^Q70L.UAS

increased cell number | somatic clone | third instar larval stage

increased cell number | somatic clone | third instar larval stage, with Scer\GAL4^ase.neuro

increased cell number | somatic clone | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

increased cell number | third instar larval stage, with Arl2^T30N.UAS, Scer\GAL4^insc.PU

Arl2^Δ156

increased cell number | third instar larval stage, with Arl2^Δ156, Scer\GAL4^insc.PU

Arl2^T30N.UAS

increased cell number | third instar larval stage, with Scer\GAL4^insc.PU

some die during pupal stage, with Scer\GAL4^pnr-MD237

Arl2^GD12240

visible, with Scer\GAL4^pnr-MD237

Arl2^GD12240

Phenotype manifest in

Allele

aster | somatic clone | third instar larval stage

aster | third instar larval stage

Arl2^GS17851

centrosome | third instar larval stage, with Scer\GAL4^insc.PU

Arl2^Q70L.UAS

ganglion mother cell | larval stage

Arl2^GD12240

larval neuroblast | increased number | third instar larval stage, with Arl2^T30N.UAS, Scer\GAL4^insc.PU

Arl2^Δ156

larval neuroblast | increased number | third instar larval stage, with Arl2^Δ156, Scer\GAL4^insc.PU

Arl2^T30N.UAS

larval neuroblast | increased number | third instar larval stage, with Scer\GAL4^insc.PU

larval neuroblast | larval stage

Arl2^GD12240

larval neuroblast | somatic clone | increased number | third instar larval stage

larval neuroblast | somatic clone | increased number | third instar larval stage, with Scer\GAL4^ase.neuro

larval neuroblast | somatic clone | increased number | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

larval neuroblast | third instar larval stage

Arl2^GS17851

larval neuroblast | third instar larval stage, with Scer\GAL4^insc.PU

Arl2^Q70L.UAS

microtubule | third instar larval stage, with Scer\GAL4^insc.PU

spindle | somatic clone | third instar larval stage

spindle | third instar larval stage

Arl2^GS17851

spindle | third instar larval stage, with Arl2^T30N.UAS, Scer\GAL4^insc.PU

Arl2^Δ156

spindle | third instar larval stage, with Arl2^Δ156, Scer\GAL4^insc.PU

Arl2^T30N.UAS

spindle | third instar larval stage, with Scer\GAL4^insc.PU

trichogen cell, with Scer\GAL4^pnr-MD237

Arl2^GD12240

type II neuroblast | somatic clone | third instar larval stage

type II neuroblast | somatic clone | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

type II neuroblast | third instar larval stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

Arl2^Q70L.UAS

type I neuroblast | somatic clone | third instar larval stage

type I neuroblast | somatic clone | third instar larval stage, with Scer\GAL4^ase.neuro

type I neuroblast | third instar larval stage, with Scer\GAL4^ase.neuro

Arl2^Q70L.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ARL2

14 of 15

Yes

Hsap\ARL2-SNX15

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Arl2

14 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Arl14

1 of 15

Rattus norvegicus (Norway rat) (8)

Rnor\Arl2

13 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Arl11

1 of 13

Rnor\Arl14

1 of 13

Xenopus tropicalis (Western clawed frog) (11)

Xtro\arl2

13 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC101734701

1 of 12

Yes

Xtro\LOC101734763

1 of 12

Yes

Danio rerio (Zebrafish) (11)

Drer\arl2

10 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\evl-20

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (7)

Atha\TTN5

8 of 9

Yes

Atha\ARF3

1 of 9

Atha\ARFB1B

1 of 9

Yes

Atha\ARFB1C

1 of 9

Yes

Atha\ARFD1A

1 of 9

Yes

Atha\ARFD1B

1 of 9

Yes

Atha\GB1

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CIN4

7 of 15

Yes

Scer\ARL3

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\alp41

11 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

dnd

4 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARL2; ADP ribosylation factor like GTPase 2

14 of 15

601175

MICROCORNEA, ROD-CONE DYSTROPHY, CATARACT, AND POSTERIOR STAPHYLOMA 1; MRCS1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Arl2 - TBCC

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2016)

Arl2 - TBCD

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Chen et al., 2016, Guruharsha et al., 2011)

Arl2 - Tbce

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2016)

Arl2 - mts

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2016)

Arl2 - αTub84B

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Chen et al., 2016)

Arl2 - βTub56D

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Chen et al., 2016)

Arl2 - βTub97EF

anti tag coimmunoprecipitation, peptide massfingerprinting

(Chen et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Arl2

suppressible

msps

(Chen et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

TBCD

enhanceable

Arl2

(Chen et al., 2016)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66174

DroID - A comprehensive database of gene and protein interactions.

FBgn0004908

MIST (genetic) - An integrated Molecular Interaction Database

Arl2

MIST (protein-protein) - An integrated Molecular Interaction Database

Arl2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004908

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84F13-84F13

Sequence location

3R:8,341,100..8,341,872 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84F13-84F13

Limits computationally determined from genome sequence between P{EP}EP833 and P{lacW}l(3)L4740^L4740

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29588

y¹ v¹; P{TRiP.JF03267}attP2

85607

w¹¹¹⁸; PBac{WH}Arl2^f00424/TM6B, Tb¹

Kyoto

200665

y¹ w^67c23; P{GSV6}Arl2^GS17851/TM3, Sb¹ Ser¹

VDRC

v110627

P{KK108053}VIE-260B

v44333

w¹¹¹⁸; P{GD12240}v44333

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM01555

Other clones

FI08808

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004908

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GM01535

Other clones

FGM214F09

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004908

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40993

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Arf84F CG7435

(Zhao, 1999.11)

Source for identity of: Arl2 Arf84F

(FlyBase, 2009-)

Source for database merge of

Additional comments

FlyBase curator comment: Renamed 'Arf84F' to 'Arl2' to reflect the 'Arl' (rather than 'Arf') symbol used in original paper (FBrf0064410), the orthology to H. sapiens ARL2, and to match the 'Arl1' symbol format.

(FlyBase, 2009-)

Suggested that "nac" may be a mutation in "Arf84F".

(Clark et al., 1993)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Encodes a small GTP-binding protein of the ADP-ribosymation factor family.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40993

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q06849

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q06849

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q06849

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004908

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40993/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004908

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004908

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004908

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7435

Flygut - An atlas of the Drosophila adult midgut

FBgn0004908

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004908

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40993

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7435

MARRVEL_MODEL - MARRVEL (model organism gene)

40993

modMine - A data warehouse for the modENCODE project

FBgn0004908

Linkouts

BioGRID - A database of protein and genetic interactions.

66174

DroID - A comprehensive database of gene and protein interactions.

FBgn0004908

DRSC - Results frm RNAi screens

FBgn0004908

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004908

FlyMine - An integrated database for Drosophila genomics

FBgn0004908

MIST (genetic) - An integrated Molecular Interaction Database

Arl2

MIST (protein-protein) - An integrated Molecular Interaction Database

Arl2

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

ARL2

(Dorer et al., 2006)

Arf

(Jekely, 2003)

Arf84D

(Orian et al., 2003)

Arf84F

(Zeledon et al., 2019, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kametaka et al., 2010, Beller et al., 2008, Guo et al., 2008, Sinka et al., 2008)

Arl2

(Kametaka et al., 2010, Pasqualato et al., 2002)

Arl84F

(Clark, 1993, Clark et al., 1993)

CG 7435

(Dorer et al., 2006)

CG7435

(Hosono et al., 2015, Christis and Munro, 2012, Li et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Colicelli, 2004, Verstreken and Bellen, 2000.9.4)

Dm Arf84F

(Jekely, 2003)

Q06849

(Rojas et al., 2012, Jekely, 2003)

arl2

(Chen et al., 2016)

Name Synonyms

ADP ribosylation factor 84F

ADP ribosylation factor like-2

(Chen et al., 2016)

ADP ribosylation factor-like 2

arflike-2