- Tools
- Downloads
- Links
- Community
- About
- Help
FB2026_01
,
released March 12, 2026
Kv4, Kv4
voltage-gated potassium channel - neuromuscular junction - regulation of action potential waveform, back-propagation and firing frequency - eliminating Shal invokes Kruppel-dependent homeostatic rebalancing of ion channel gene expression including enhanced slo, Shab, and Shaker - photoperiod, contributes to currents in the motoneurons - locomotion, SIDL regulates LL-motif-dependent targeting of K(+) channels, shal and shaker, are reciprocally, transcriptionally coupled to maintain A-type channel expression
Please see the JBrowse view of Dmel\Shal for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
None of the polypeptides share 100% sequence identity.
490 (aa)
605, 490 (aa); 56 (kD predicted)
Co-injection experiments in Xenopus oocytes were
used to test for formation of functional heterodimers between Sh
subfamily members. In fact, no functional heterodimers (as shown by novel
current kinetics) were detected when all pairwise combinations of the four
different channel subfamilies (Sh, Shab, Shal, and Shaw) were
tested. The independence of each channel system was retained even when all
four were co-expressed.
Shal protein was expressed in Xenopus oocytes and characterized with respect to kinetics (rate of macroscopic current activation and inactivation) and voltage sensitivity of steady-state inactivation. Those properties were compared among the Sh subfamily members and found to vary widely. Shal encodes the transient (A current)subtype of potassium channel and appears to function as a homomultimer.
Heterotetramer of potassium channel proteins (By similarity). Interacts (via C-terminal dendritic targeting motif) with SIDL.
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shal using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Shal in JBrowse
3-45
3-42.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
The monkey Cos cell line is a reasonable system for transient expression of K+ channels, particularly those with fast inactivation kinetics.
Shal encodes virtually all the transient K+ currents observed in embryonic neurons.
Yeast two-hybrid system studies demonstrate the association of the hydrophilic N-terminal domains of the genes encoding channel proteins plays an important role in determining the specificity of α subunit association to form heteromultimeric potassium channels.
Potassium channel diversity could result from an extended gene family as well as from alternate splicing of the Sh primary transcript.
Expression of Shal cDNA-derived mRNA in Xenopus oocytes (Wei, Covarrubias, Butler, Baker, Pak and Salkoff, 1990a; Wei, Covarrubias, Butler, Baker, Pak and Salkoff, 1990b) leads to potassium currents intermediate in kinetic properties between those associated with Sh (using the heterologous egg system) and Shaw (same kind of experiment), i.e., between very rapid activation/inactivation (Sh-encoded 'A'-type channels) and quite slow kinetics (Shaw-encoded, delayed-rectifier-type channels).
