FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Sox14
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General Information
Symbol
Dmel\Sox14
Species
D. melanogaster
Name
Sox box protein 14
Annotation Symbol
CG3090
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005612
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Sox box protein 14 (Sox14) encodes a transcription factor involved in neurogenesis and metamorphosis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DSox14

Key Links
Genomic Location
Cytogenetic map
60A16-60A16
Sequence location
Recombination map
2-105
RefSeq locus
NT_033778 REGION:23978801..23985177
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA binding, bending
inferred from direct assay
(Sparkes et al., 2001)
enables sequence-specific DNA binding
inferred from direct assay
(Sparkes et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in dendrite morphogenesis
inferred from genetic interaction with FLYBASE:Mical; FB:FBgn0053208
(Kirilly et al., 2009)
involved_in metamorphosis
inferred from mutant phenotype
(Ritter and Beckstead, 2010)
involved_in neuron remodeling
inferred from genetic interaction with FLYBASE:Mical; FB:FBgn0053208
(Kirilly et al., 2009)
involved_in positive regulation of neuron remodeling
inferred from mutant phenotype
(Wong et al., 2013)
involved_in regulation of neuron remodeling
inferred from mutant phenotype
(Loncle and Williams, 2012)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Ritter and Beckstead, 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in brain development
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN008496689
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from mutant phenotype
(Ritter and Beckstead, 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000030384
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Sox box protein 14 (Sox14) encodes a transcription factor involved in neurogenesis and metamorphosis. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -
The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sox14 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P40656)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sox14-RA
FBtr0072157
NM_057546
3281
669
Sox14-RB
FBtr0072158
NM_134290
2485
669
Sox14-RC
FBtr0343282
NM_001299872
3579
669
Additional Transcript Data and Comments
Reported size (kB)

3.6, 3.3, 2.5 (northern blot)

(Sparkes et al., 2001)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sox14-PA
FBpp0072066
72.7
669
5.54
P40656
NP_476894
AAM68286
Sox14-PB
FBpp0072067
72.7
669
5.54
P40656
NP_599117
AAF47126
Sox14-PC
FBpp0309947
72.7
669
5.54
P40656
NP_001286801
AHN56596
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

669 aa isoforms: Sox14-PA, Sox14-PB, Sox14-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

669 (aa); 72 (kD observed); 72.7 (kD predicted)

(Sparkes et al., 2001)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox14 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.64

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | faint | ubiquitous
(Sparkes et al., 2001)
embryonic stage 7 -- 8
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
longitudinal trunk visceral muscle primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Fisher et al., 2012)
third instar larval stage
embryonic/larval salivary gland
(Cremazy et al., 2001)
inferred from author statements
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Cremazy et al., 2001)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Sparkes et al., 2001)
wandering third instar larval stage
organism

Comment: reference states 4 hours before puparium formation

(Ritter and Beckstead, 2010)
prepupal stage P1 -- P2
organism
(Ritter and Beckstead, 2010)
prepupal stage P4(ii)
organism
(Ritter and Beckstead, 2010)
pupal stage
(Sparkes et al., 2001)
pharate adult stage
organism
(Sparkes et al., 2001)
adult stage
(Sparkes et al., 2001)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Sparkes et al., 2001)
embryonic stage 12 -- 17

Comment: reference states 8-24 hr AEL

(Sparkes et al., 2001)
pupal stage
(Sparkes et al., 2001)
Additional Descriptive Data

Expression of Sox14 coincides with a pulse of ecdysone shortly before puparium formation, and a second wave at 10 hours after pupation.

(Ritter and Beckstead, 2010)

Sox14 transcript is also expressed in the larval gut, but not in imaginal discs.

(Cremazy et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
prepupal stage P1
fat body
(Ritter and Beckstead, 2010)
salivary gland
(Ritter and Beckstead, 2010)
hindgut
(Ritter and Beckstead, 2010)
midgut | subset
(Ritter and Beckstead, 2010)
epidermis | subset
(Ritter and Beckstead, 2010)
peripodial epithelium
(Ritter and Beckstead, 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Sparkes et al., 2001)
third instar larval stage
(Sparkes et al., 2001)
Additional Descriptive Data

Sox14 was observed to increase in fat body, salivary gland, hindgut, midgut, epidermis, and peripodial epithelium at the time of puparium formation, in contrast to 18 hours before puparium formation. This coincides with a wave of ecdysone present from 4 hours before pupation to 2 hours after pupation (late L3 to pupal stage P2).

(Ritter and Beckstead, 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from mutant phenotype
(Ritter and Beckstead, 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sox14 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sox14
Transgenic constructs containing regulatory region of Sox14
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(2R)Exel6080
(Ryder, 2004.4.26)
Df(2R)Exel7182
(Ryder, 2004.4.26)
Df(2R)PhmP(29)
(Jiang et al., 2000)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | pharate adult stage
lethal | pharate adult stage (with Df(2R)BSC136)
lethal | prepupal stage
lethal | prepupal stage (with Df(2R)BSC136)
lethal | pupal stage
lethal | pupal stage (with Df(2R)BSC136)
lethal - all die before end of pupal stage
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4109(2)80
abnormal neuroanatomy, with Scer\GAL4221
abnormal neuroanatomy, with Scer\GAL4ppk.1.9
abnormal neuroanatomy (with Df(2R)BSC136)
abnormal neuroanatomy (with Df(2R)or-BR11)
abnormal neuroanatomy (with Sox14Δ13)
abnormal neuroanatomy (with Sox14Δ15)
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neuroanatomy | somatic clone
decreased cell death, with Scer\GAL4ppk.1.9
some die during pupal stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
visible | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult abdomen | pharate adult stage
anterior pupal spiracle
dendrite
dendrite, with Scer\GAL4221
dendrite, with Scer\GAL4ppk.1.9
dendrite (with Df(2R)BSC136)
dendrite (with Df(2R)or-BR11)
dendrite (with Sox14Δ13)
dendrite (with Sox14Δ15)
dendrite | somatic clone
larval dorsal multidendritic neuron ddaC
larval dorsal multidendritic neuron ddaC, with Scer\GAL4221
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaC (with Df(2R)BSC136)
larval dorsal multidendritic neuron ddaC (with Df(2R)or-BR11)
larval dorsal multidendritic neuron ddaC (with Sox14Δ13)
larval dorsal multidendritic neuron ddaC (with Sox14Δ15)
larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone
larval dorsal multidendritic neuron ddaC | somatic clone
mesonotum, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4Bx-MS1096
wing | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (53)
Hsap\SOX4
7 of 14
Yes
Yes
Hsap\SOX11
6 of 14
No
Yes
Hsap\SOX12
6 of 14
No
Yes
1  
Hsap\SOX2
5 of 14
No
No
1  
Hsap\SOX3
5 of 14
No
Yes
Hsap\SOX7
5 of 14
No
No
Hsap\SOX14
5 of 14
No
No
Hsap\SOX15
5 of 14
No
Yes
1  
Hsap\SOX17
5 of 14
No
Yes
1  
Hsap\SOX18
5 of 14
No
No
Hsap\SOX1
4 of 14
No
No
Hsap\SOX8
4 of 14
No
No
Hsap\SOX9
4 of 14
No
No
Hsap\SOX10
4 of 14
No
No
Hsap\SOX13
4 of 14
No
No
Hsap\SOX21
4 of 14
No
No
0  
Hsap\SRY
4 of 14
No
Yes
Hsap\SOX5
3 of 14
No
No
Hsap\SOX6
3 of 14
No
No
Hsap\SOX30
3 of 14
No
Yes
Hsap\BBX
1 of 14
No
No
1  
Hsap\CFAP65
1 of 14
No
Yes
Hsap\CIC
1 of 14
No
No
1  
Hsap\HBP1
1 of 14
No
No
Hsap\HMG20A
1 of 14
No
No
1  
Hsap\HMG20B
1 of 14
No
No
1  
Hsap\HMGB1
1 of 14
No
No
1  
Hsap\HMGB1P1
1 of 14
No
No
Hsap\HMGB2
1 of 14
No
No
Hsap\HMGB3
1 of 14
No
No
1  
Hsap\HMGB4
1 of 14
No
No
Hsap\LDB3
1 of 14
No
No
1  
Hsap\LEF1
1 of 14
No
No
2  
Hsap\LPXN
1 of 14
No
No
1  
Hsap\MEIOSIN
1 of 14
No
Yes
Hsap\PDLIM1
1 of 14
No
No
Hsap\PDLIM2
1 of 14
No
No
Hsap\PDLIM3
1 of 14
No
No
Hsap\PDLIM4
1 of 14
No
No
Hsap\PDLIM5
1 of 14
No
No
Hsap\PDLIM7
1 of 14
No
No
Hsap\PXN
1 of 14
No
No
Hsap\SP100
1 of 14
No
No
Hsap\SSRP1
1 of 14
No
No
1  
Hsap\SYNPO2
1 of 14
No
No
Hsap\SYNPO2L
1 of 14
No
No
Hsap\TCF7
1 of 14
No
No
Hsap\TCF7L1
1 of 14
No
No
1  
Hsap\TCF7L2
1 of 14
No
No
Hsap\TFAM
1 of 14
No
No
1  
Hsap\TGFB1I1
1 of 14
No
No
Hsap\TOX4
1 of 14
No
No
1  
Hsap\UBTF
1 of 14
No
No
3  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (31)
Rnor\Sox11
7 of 14
Yes
Yes
Rnor\Sox12
6 of 14
No
Yes
Rnor\Sox2
5 of 14
No
No
Rnor\Sox7
5 of 14
No
No
Rnor\Sox14
5 of 14
No
No
Rnor\Sox17
5 of 14
No
No
Rnor\Sox18
5 of 14
No
No
Rnor\Sox8
4 of 14
No
No
Rnor\Sox9
4 of 14
No
No
Rnor\Sox10
4 of 14
No
No
Rnor\Sox13
4 of 14
No
No
Rnor\Sry
3 of 14
No
Yes
Rnor\Sox5
2 of 14
No
No
Rnor\Sox6
2 of 14
No
No
Rnor\Cfap65
1 of 14
No
Yes
Rnor\Cic
1 of 14
No
No
Rnor\Lef1
1 of 14
No
No
Rnor\Lpxn
1 of 14
No
No
Rnor\Pdlim1
1 of 14
No
No
Rnor\Pdlim2
1 of 14
No
No
Rnor\Pdlim3
1 of 14
No
No
Rnor\Pdlim4
1 of 14
No
No
Rnor\Pdlim5
1 of 14
No
No
Rnor\Pdlim7
1 of 14
No
No
Rnor\Sox30
1 of 14
No
Yes
Rnor\Synpo2l
1 of 14
No
No
Rnor\Synpo2
1 of 14
No
No
Rnor\Tcf7l1
1 of 14
No
No
Rnor\Tcf7l2
1 of 14
No
No
Rnor\Tcf7
1 of 14
No
No
Rnor\Tgfb1i1
1 of 14
No
No
Mus musculus (laboratory mouse) (41)
Mmus\Sox4
7 of 14
Yes
Yes
Mmus\Sox11
7 of 14
Yes
Yes
Mmus\Sox12
6 of 14
No
Yes
Mmus\Sox2
5 of 14
No
No
4  
Mmus\Sox3
5 of 14
No
Yes
Mmus\Sox7
5 of 14
No
No
Mmus\Sox14
5 of 14
No
No
Mmus\Sox15
5 of 14
No
Yes
Mmus\Sox17
5 of 14
No
No
Mmus\Sox18
5 of 14
No
No
Mmus\Sry
5 of 14
No
Yes
Mmus\Sox1
4 of 14
No
No
Mmus\Sox8
4 of 14
No
No
Mmus\Sox9
4 of 14
No
No
Mmus\Sox10
4 of 14
No
No
Mmus\Sox21
4 of 14
No
No
Mmus\Sox13
3 of 14
No
No
Mmus\Sox30
3 of 14
No
Yes
Mmus\Sox5
2 of 14
No
No
Mmus\Sox6
2 of 14
No
No
Mmus\Sox16
2 of 14
No
Yes
Mmus\Sox19
2 of 14
No
Yes
Mmus\Cfap65
1 of 14
No
Yes
Mmus\Cic
1 of 14
No
No
Mmus\Hmg20a
1 of 14
No
No
Mmus\Ldb3
1 of 14
No
No
Mmus\Lef1
1 of 14
No
No
1  
Mmus\Lpxn
1 of 14
No
No
Mmus\Meiosin
1 of 14
No
No
Mmus\Pdlim1
1 of 14
No
No
Mmus\Pdlim2
1 of 14
No
No
Mmus\Pdlim3
1 of 14
No
No
Mmus\Pdlim4
1 of 14
No
No
Mmus\Pdlim5
1 of 14
No
No
Mmus\Pdlim7
1 of 14
No
No
Mmus\Pxn
1 of 14
No
No
Mmus\Synpo2l
1 of 14
No
No
Mmus\Synpo2
1 of 14
No
No
Mmus\Tcf7l1
1 of 14
No
No
Mmus\Tcf7l2
1 of 14
No
No
Mmus\Tcf7
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (41)
Xtro\sox11
6 of 13
Yes
Yes
Xtro\sox4
5 of 13
No
Yes
Xtro\LOC116407953
3 of 13
No
Yes
Xtro\sox1
3 of 13
No
No
Xtro\sox2
3 of 13
No
No
Xtro\sox3
3 of 13
No
No
Xtro\sox7
3 of 13
No
No
Xtro\sox14
3 of 13
No
No
Xtro\sox17a
3 of 13
No
No
Xtro\sox17b.1
3 of 13
No
No
Xtro\sox17b.2
3 of 13
No
No
Xtro\sox18
3 of 13
No
No
Xtro\sox8
2 of 13
No
No
Xtro\sox9
2 of 13
No
No
Xtro\sox10
2 of 13
No
No
Xtro\sox13
2 of 13
No
No
Xtro\bbx
1 of 13
No
No
Xtro\cdk1
1 of 13
No
No
Xtro\cic
1 of 13
No
No
Xtro\hbp1
1 of 13
No
No
Xtro\hmg20a
1 of 13
No
No
Xtro\hmg20b
1 of 13
No
No
Xtro\hmgb1
1 of 13
No
No
Xtro\hmgb2
1 of 13
No
No
Xtro\hmgb3
1 of 13
No
No
Xtro\LOC101732411
1 of 13
No
Yes
Xtro\LOC101734060
1 of 13
No
Yes
Xtro\mob3c
1 of 13
No
No
Xtro\pcmt1
1 of 13
No
No
Xtro\pms1
1 of 13
No
No
Xtro\sap130
1 of 13
No
No
Xtro\sox5
1 of 13
No
No
Xtro\sox6
1 of 13
No
No
Xtro\sox15
1 of 13
No
Yes
Xtro\sox21
1 of 13
No
No
Xtro\sphk2
1 of 13
No
No
Xtro\tcf7l1
1 of 13
No
No
Xtro\tcf7
1 of 13
No
No
Xtro\tox2
1 of 13
No
No
Xtro\tox4
1 of 13
No
No
Xtro\vegfc
1 of 13
No
Yes
Danio rerio (Zebrafish) (47)
Drer\sox4a
7 of 14
Yes
Yes
Drer\sox11a
7 of 14
Yes
Yes
Drer\sox11b
7 of 14
Yes
Yes
Drer\sox12
7 of 14
Yes
Yes
Drer\sox2
5 of 14
No
No
Drer\sox3
5 of 14
No
No
Drer\sox4b
5 of 14
No
Yes
Drer\sox14
5 of 14
No
No
Drer\sox18
5 of 14
No
No
Drer\sox19b
5 of 14
No
No
Drer\sox21a
5 of 14
No
No
Drer\sox1a
4 of 14
No
No
Drer\sox1b
4 of 14
No
No
Drer\sox7
4 of 14
No
No
Drer\sox8b
4 of 14
No
No
Drer\sox9a
4 of 14
No
No
Drer\sox10
4 of 14
No
No
Drer\sox17
4 of 14
No
No
Drer\sox19a
4 of 14
No
No
Drer\sox21b
4 of 14
No
No
Drer\sox32
4 of 14
No
Yes
Drer\LOC103910042
3 of 14
No
No
Drer\sox8a
3 of 14
No
No
Drer\sox9b
3 of 14
No
No
Drer\sox13
2 of 14
No
No
Drer\bbx
1 of 14
No
No
Drer\cfap65
1 of 14
No
Yes
Drer\cica
1 of 14
No
No
Drer\cicb
1 of 14
No
No
Drer\lef1
1 of 14
No
No
Drer\lpxn
1 of 14
No
No
Drer\pbrm1l
1 of 14
No
No
Drer\pdlim1
1 of 14
No
No
Drer\pdlim2
1 of 14
No
No
Drer\pdlim3a
1 of 14
No
No
Drer\pdlim3b
1 of 14
No
No
Drer\pdlim4
1 of 14
No
No
Drer\pxna
1 of 14
No
No
Drer\pxnb
1 of 14
No
No
Drer\sox5
1 of 14
No
No
Drer\sox6
1 of 14
No
No
Drer\synpo2la
1 of 14
No
No
Drer\synpo2lb
1 of 14
No
No
Drer\tcf7
1 of 14
No
No
Drer\tcf7l1a
1 of 14
No
No
Drer\tcf7l1b
1 of 14
No
No
Drer\tcf7l2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\sem-2
5 of 14
Yes
Yes
Cele\sox-3
5 of 14
Yes
No
Cele\sox-4
5 of 14
Yes
Yes
Cele\sox-2
4 of 14
No
No
Cele\pop-1
3 of 14
No
No
Cele\egl-13
2 of 14
No
No
Cele\C26C6.6
1 of 14
No
No
Cele\C34B2.4
1 of 14
No
No
Cele\F33D11.1
1 of 14
No
No
Cele\gei-3
1 of 14
No
No
Cele\hmg-1.1
1 of 14
No
No
Cele\hmg-1.2
1 of 14
No
No
Cele\hmg-3
1 of 14
No
No
Cele\hmg-4
1 of 14
No
No
Cele\hmg-20
1 of 14
No
No
Cele\unc-95
1 of 14
No
No
Cele\Y1A5A.1
1 of 14
No
No
Cele\Y65B4A.7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (20)
Agam\AgaP_AGAP005183
5 of 12
Yes
Yes
Agam\AgaP_AGAP009957
4 of 12
No
No
Agam\AgaP_AGAP010919
4 of 12
No
No
Agam\AgaP_AGAP010922
4 of 12
No
No
Agam\AgaP_AGAP010923
4 of 12
No
No
Agam\AgaP_AGAP000066
3 of 12
No
No
Agam\AgaP_AGAP000922
3 of 12
No
No
Agam\AgaP_AGAP012033
2 of 12
No
No
Agam\AgaP_AGAP000005
1 of 12
No
No
Agam\AgaP_AGAP000281
1 of 12
No
No
Agam\AgaP_AGAP000755
1 of 12
No
No
Agam\AgaP_AGAP004789
1 of 12
No
No
Agam\AgaP_AGAP004791
1 of 12
No
No
Agam\AgaP_AGAP008499
1 of 12
No
No
Agam\AgaP_AGAP008532
1 of 12
No
No
Agam\AgaP_AGAP012334
1 of 12
No
No
Agam\AgaP_AGAP012335
1 of 12
No
No
Agam\AgaP_AGAP012389
1 of 12
No
No
Agam\AgaP_AGAP012411
1 of 12
No
No
Agam\AgaP_AGAP013411
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (17)
Atha\3xHMG-box1
2 of 13
Yes
No
Atha\3xHMG-box2
2 of 13
Yes
No
Atha\AT1G04880
1 of 13
No
No
Atha\AT4G36860
1 of 13
No
No
Atha\DA1
1 of 13
No
No
Atha\DAR2
1 of 13
No
No
Atha\DAR3
1 of 13
No
No
Atha\DAR4
1 of 13
No
No
Atha\DAR5
1 of 13
No
No
Atha\DAR6
1 of 13
No
No
Atha\DAR7
1 of 13
No
No
Atha\HMG
1 of 13
No
No
Atha\HMGB1
1 of 13
No
No
Atha\HMGB2
1 of 13
No
No
Atha\HMGB3
1 of 13
No
No
Atha\HMGB4
1 of 13
No
No
Atha\HMGB5
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\ROX1
3 of 13
Yes
No
Scer\IXR1
2 of 13
No
No
Scer\ABF2
1 of 13
No
No
Scer\HMO1
1 of 13
No
No
Scer\LRG1
1 of 13
No
No
Scer\NHP6A
1 of 13
No
No
Scer\NHP6B
1 of 13
No
No
Scer\NHP10
1 of 13
No
No
Scer\PXL1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\matmc_1
3 of 12
Yes
No
Spom\matmc_2
3 of 12
Yes
No
Spom\ste11
2 of 12
No
No
Spom\pxl1
1 of 12
No
No
Spom\rga1
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sox14. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (20)
Sox15
6 of 13
Sox21a
6 of 13
Sox21b
6 of 13
SoxN
6 of 13
D
5 of 13
Sox100B
5 of 13
Sox102F
4 of 13
cic
2 of 13
pan
2 of 13
bbx
1 of 13
CG30178
1 of 13
CG31624
1 of 13
CG31988
1 of 13
CG34325
1 of 13
Dsp1
1 of 13
HmgD
1 of 13
HmgZ
1 of 13
Pax
1 of 13
Ssrp
1 of 13
Zasp52
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 6 )
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SOX4; SRY-box transcription factor 4
    7 of 14
    184430
    SOX11; SRY-box transcription factor 11
    6 of 14
    600898
    SOX12; SRY-box transcription factor 12
    6 of 14
    601947
         
        SOX2; SRY-box transcription factor 2
        5 of 14
        184429
         
        SOX3; SRY-box transcription factor 3
        5 of 14
        313430
        SOX7; SRY-box transcription factor 7
        5 of 14
        612202
            SOX14; SRY-box transcription factor 14
            5 of 14
            604747
                SOX15; SRY-box transcription factor 15
                5 of 14
                601297
                     
                    SOX17; SRY-box transcription factor 17
                    5 of 14
                    610928
                     
                    SOX18; SRY-box transcription factor 18
                    5 of 14
                    601618
                    SOX1; SRY-box transcription factor 1
                    4 of 14
                    602148
                        SOX8; SRY-box transcription factor 8
                        4 of 14
                        605923
                            SOX9; SRY-box transcription factor 9
                            4 of 14
                            608160
                            SOX10; SRY-box transcription factor 10
                            4 of 14
                            602229
                            SOX13; SRY-box transcription factor 13
                            4 of 14
                            604748
                                SOX21; SRY-box transcription factor 21
                                4 of 14
                                604974
                                     
                                    SRY; sex determining region Y
                                    4 of 14
                                    480000
                                    SOX5; SRY-box transcription factor 5
                                    3 of 14
                                    604975
                                      SOX6; SRY-box transcription factor 6
                                      3 of 14
                                      607257
                                        SOX30; SRY-box transcription factor 30
                                        3 of 14
                                        606698
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            Interaction Browsers
                                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                                            Please see the Physical Interaction reports below for full details
                                            protein-protein
                                            Physical Interaction
                                            Assay
                                            References
                                            Sox14 - CrebA
                                            two hybrid array
                                            (Shokri et al., 2019)
                                            Summary of Genetic Interactions
                                            Interaction Browsers
                                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                                            Please look at the allele data for full details of the genetic interactions
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Sox14
                                            suppressible
                                            Mical
                                            (Kirilly et al., 2009)
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            brm
                                            suppressible
                                            Sox14
                                            (Tegeder et al., 2019)
                                            EcR
                                            suppressible
                                            Sox14
                                            (Kirilly et al., 2009)
                                            Mical
                                            suppressible
                                            Sox14
                                            (Kirilly et al., 2009)
                                            External Data
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            DroID - A comprehensive database of gene and protein interactions.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            FlyBase
                                            External Links
                                            External Data
                                            Linkouts
                                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                            Class of Gene
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            2R
                                            Recombination map
                                            2-105
                                            Cytogenetic map
                                            60A16-60A16
                                            Sequence location
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            60A16-60A16
                                            Limits computationally determined from genome sequence between P{EP}TalEP489&P{EP}CG3065EP316 and P{lacW}Phmk07623&P{lacW}tsrk05633
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            60A8-60B8
                                            (determined by in situ hybridisation)
                                            (Sparkes et al., 2001)
                                            60B1-60B2
                                            (Girad, 1999.12.21, Sparkes et al., 1997)
                                            Experimentally Determined Recombination Data
                                            Location

                                            2-105

                                            (FlyBase, 2016)

                                            2-109.8

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            Right of (cM)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (11)
                                            Genomic Clones (20)
                                            cDNA Clones (20)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequenced
                                            BDGP DGC clones
                                            Other clones
                                            Drosophila Genomics Resource Center cDNA clones

                                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                            cDNA Clones, End Sequenced (ESTs)
                                            BDGP DGC clones
                                            Other clones
                                            RNAi and Array Information
                                            Linkouts
                                            DRSC - Results frm RNAi screens
                                            Antibody Information
                                            Laboratory Generated Antibodies
                                             

                                            polyclonal

                                            (Ritter and Beckstead, 2010, Kirilly et al., 2009, Sparkes et al., 2001)
                                            Commercially Available Antibodies
                                             
                                            Cell Line Information
                                            Publicly Available Cell Lines
                                             
                                              Other Stable Cell Lines
                                               
                                                Other Comments

                                                Area matching Drosophila EST AA950164.

                                                (Davies, 2001.3.15)
                                                Relationship to Other Genes
                                                Source for database merge of

                                                Source for merge of: Sox14 CG17263

                                                (Whitfield, 2000.8.29)
                                                Additional comments

                                                l(2)k06608b may correspond to Sox14: the P{lacW}l(2)k06608bk06608b insertion maps within the transcription unit.

                                                (Gene Disruption Project members, 2015.10.8)

                                                Release 1 annotation CG17263 contained sequences corresponding to both of the release 3.2 annotations CG3090 (Sox14) and CG30178.

                                                (FlyBase, 1996-)
                                                Nomenclature History
                                                Source for database identify of

                                                Source for identity of: Sox14 CG3090

                                                (Wang, 1999.11)
                                                Nomenclature comments
                                                Etymology
                                                Synonyms and Secondary IDs (14)
                                                Reported As
                                                Symbol Synonym
                                                CG17263
                                                (Kashevsky et al., 2002, Jiang et al., 2000, Whitfield, 2000.8.29)
                                                CG3090
                                                (Neuert et al., 2017, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Lee et al., 2003, Kashevsky et al., 2002, Cremazy et al., 2001, Taghert, 2000.4.2)
                                                DSox-14
                                                (Denny et al., 1992)
                                                DSox14
                                                (Sparkes et al., 2001, Crane-Robinson, 2000.5.27)
                                                DSox60B
                                                (Sparkes et al., 1997)
                                                Dsox-14
                                                (Denny, 1992.4.23)
                                                SOX14
                                                (Yang et al., 2012, Bowles et al., 2000)
                                                SOX60B
                                                (Bowles et al., 2000)
                                                SOXC
                                                (Bowles et al., 2000)
                                                Sox-14
                                                (Yaniv and Schuldiner, 2016)
                                                Sox14
                                                (McLamb et al., 2025, Tang et al., 2025, Li et al., 2024, Liu et al., 2024, Rui, 2024, Fisher et al., 2023, Furusawa et al., 2023, Zhao et al., 2023, Beaver et al., 2022, Jia et al., 2022, Saha et al., 2022, Bilder et al., 2021, Furusawa and Emoto, 2021, Xie et al., 2021, Krautz et al., 2020, Rui et al., 2020, Rust et al., 2020, Wolterhoff et al., 2020, Krämer et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Gene Disruption Project members, 2018-, Janssen et al., 2018, Rode et al., 2018, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Brewer-Jensen et al., 2016, Schertel et al., 2015, Rumpf et al., 2014, Victorsen and White, 2014.4.15, Wong et al., 2013, Loncle and Williams, 2012, Phochanukul and Russell, 2010, Chittaranjan et al., 2009, Kirilly et al., 2009, Gilchrist et al., 2008, Zhou et al., 2008, Sessa and Bianchi, 2007, Hoskins et al., 2005)
                                                sox14
                                                (Stewart et al., 2024, Keder et al., 2020, Xu et al., 2020, Zhu et al., 2019, Wong et al., 2013, Awofala et al., 2012, Kirilly et al., 2011, Ritter and Beckstead, 2010, Kirilly et al., 2009, Foglietti et al., 2006, Beckstead et al., 2005)
                                                Name Synonyms
                                                Sox box protein 14
                                                sox box protein 14
                                                (Beckstead et al., 2005)
                                                Secondary FlyBase IDs
                                                • FBgn0034949
                                                Datasets (0)
                                                Study focus (0)
                                                Experimental Role
                                                Project
                                                Project Type
                                                Title
                                                Study result (0)
                                                Result
                                                Result Type
                                                Title
                                                External Crossreferences and Linkouts ( 45 )
                                                Sequence Crossreferences
                                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                Other crossreferences
                                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                FlyMine - An integrated database for Drosophila genomics
                                                InterPro - A database of protein families, domains and functional sites
                                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                                Linkouts
                                                BioGRID - A database of protein and genetic interactions.
                                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                DroID - A comprehensive database of gene and protein interactions.
                                                DRSC - Results frm RNAi screens
                                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                Flygut - An atlas of the Drosophila adult midgut
                                                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                References (115)