FlyBase Gene Report: Dmel\Sox14

General Information

Symbol

Dmel\Sox14

Species

D. melanogaster

Name

Sox box protein 14

Annotation Symbol

CG3090

Feature Type

protein_coding_gene

FlyBase ID

FBgn0005612

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Sox box protein 14 (Sox14) encodes a transcription factor involved in neurogenesis and metamorphosis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DSox14

Key Links

Genomic Location

Cytogenetic map

60A16-60A16

Sequence location

2R:23,978,801..23,985,177 [+]

Recombination map

2-105

RefSeq locus

NT_033778 REGION:23978801..23985177

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables DNA binding, bending

inferred from direct assay

(Sparkes et al., 2001)

enables sequence-specific DNA binding

inferred from direct assay

(Sparkes et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in dendrite morphogenesis

inferred from genetic interaction with FLYBASE:Mical; FB:FBgn0053208

(Kirilly et al., 2009)

involved_in metamorphosis

inferred from mutant phenotype

(Ritter and Beckstead, 2010)

involved_in neuron remodeling

inferred from genetic interaction with FLYBASE:Mical; FB:FBgn0053208

(Kirilly et al., 2009)

involved_in positive regulation of neuron remodeling

inferred from mutant phenotype

(Wong et al., 2013)

involved_in regulation of neuron remodeling

inferred from mutant phenotype

(Loncle and Williams, 2012)

involved_in regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Ritter and Beckstead, 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in anatomical structure morphogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription, DNA-templated

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from mutant phenotype

(Ritter and Beckstead, 2010)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Sox box protein 14 (Sox14) encodes a transcription factor involved in neurogenesis and metamorphosis. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -: The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sox14 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sox14-RA

FBtr0072157

NM_057546

3281

669

Sox14-RB

FBtr0072158

NM_134290

2485

669

Sox14-RC

FBtr0343282

NM_001299872

3579

669

Additional Transcript Data and Comments

Reported size (kB)

3.6, 3.3, 2.5 (northern blot)

(Sparkes et al., 2001)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Sox14-PA

FBpp0072066

72.7

669

5.54

NP_476894

AAM68286

Sox14-PB

FBpp0072067

72.7

669

5.54

NP_599117

AAF47126

Sox14-PC

FBpp0309947

72.7

669

5.54

NP_001286801

AHN56596

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

669 aa isoforms: Sox14-PA, Sox14-PB, Sox14-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

669 (aa); 72 (kD observed); 72.7 (kD predicted)

(Sparkes et al., 2001)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox14 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | faint | ubiquitous

(Sparkes et al., 2001)

embryonic stage 7 -- 8

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

longitudinal visceral muscle primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

third instar larval stage

embryonic/larval salivary gland

(Cremazy et al., 2001)

inferred from author statements

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Cremazy et al., 2001)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Sparkes et al., 2001)

wandering third instar larval stage

organism

Comment: reference states 4 hours before puparium formation

(Ritter and Beckstead, 2010)

prepupal stage P1 -- P2

organism

(Ritter and Beckstead, 2010)

prepupal stage P4(ii)

organism

(Ritter and Beckstead, 2010)

pupal stage

(Sparkes et al., 2001)

pharate adult stage

organism

(Sparkes et al., 2001)

adult stage

(Sparkes et al., 2001)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Sparkes et al., 2001)

embryonic stage 12 -- 17

Comment: reference states 8-24 hr AEL

(Sparkes et al., 2001)

pupal stage

(Sparkes et al., 2001)

Additional Descriptive Data

Expression of Sox14 coincides with a pulse of ecdysone shortly before puparium formation, and a second wave at 10 hours after pupation.

(Ritter and Beckstead, 2010)

Sox14 transcript is also expressed in the larval gut, but not in imaginal discs.

(Cremazy et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

prepupal stage P1

fat body

(Ritter and Beckstead, 2010)

salivary gland

(Ritter and Beckstead, 2010)

hindgut

(Ritter and Beckstead, 2010)

midgut | subset

(Ritter and Beckstead, 2010)

epidermis | subset

(Ritter and Beckstead, 2010)

peripodial epithelium

(Ritter and Beckstead, 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Sparkes et al., 2001)

third instar larval stage

(Sparkes et al., 2001)

Additional Descriptive Data

Sox14 was observed to increase in fat body, salivary gland, hindgut, midgut, epidermis, and peripodial epithelium at the time of puparium formation, in contrast to 18 hours before puparium formation. This coincides with a wave of ecdysone present from 4 hours before pupation to 2 hours after pupation (late L3 to pupal stage P2).

(Ritter and Beckstead, 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from mutant phenotype

(Ritter and Beckstead, 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sox14 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sox14

View exonic expression by tissue for Dmel\Sox14

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005612

DRscDB

37822/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0005612

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3090-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0005612

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sox14

Transgenic constructs containing regulatory region of Sox14

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2R)Exel6080

(Ryder, 2004.4.26)

Df(2R)Exel7182

(Ryder, 2004.4.26)

Df(2R)Phm^P(29)

(Jiang et al., 2000)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | pharate adult stage

Sox14^L1

lethal | pharate adult stage (with Df(2R)BSC136)

Sox14^L1

lethal | prepupal stage

Sox14^L1

lethal | prepupal stage (with Df(2R)BSC136)

Sox14^L1

lethal | pupal stage

Sox14^L1

lethal | pupal stage (with Df(2R)BSC136)

Sox14^L1

lethal - all die before end of pupal stage

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Sox14^GD4416

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Sox14^GD4416

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sox14^GD4416

viable, with Scer\GAL4^tin.CΔ4

Sox14^GD4416

Other Phenotypes

Allele

abnormal neuroanatomy

Sox14^Δ13

abnormal neuroanatomy, with Scer\GAL4^109(2)80

Sox14^GD4416

abnormal neuroanatomy, with Scer\GAL4²²¹

Sox14^fl.UAS

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

abnormal neuroanatomy (with Df(2R)BSC136)

Sox14^Δ13

abnormal neuroanatomy (with Df(2R)or-BR11)

Sox14^Δ15

abnormal neuroanatomy (with Sox14^Δ13)

Sox14^Δ15

abnormal neuroanatomy (with Sox14^Δ15)

Sox14^Δ13

abnormal neuroanatomy | pupal stage | somatic clone

Sox14^Δ13

abnormal neuroanatomy | somatic clone

Sox14^Δ15

decreased cell death, with Scer\GAL4^ppk.1.9

Sox14^GD4416

some die during pupal stage

some die during pupal stage, with Scer\GAL4^pnr-MD237

Sox14^GD4416

visible, with Scer\GAL4^Bx-MS1096

Sox14^{UAS.ORF.GW.Tag:HA}

visible, with Scer\GAL4^pnr-MD237

Sox14^GD4416

visible | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox14^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

adult abdomen | pharate adult stage

Sox14^L1

anterior pupal spiracle

Sox14^L1

dendrite

Sox14^Δ13

dendrite, with Scer\GAL4²²¹

Sox14^fl.UAS

dendrite, with Scer\GAL4^ppk.1.9

dendrite (with Df(2R)BSC136)

Sox14^Δ13

dendrite (with Df(2R)or-BR11)

Sox14^Δ15

dendrite (with Sox14^Δ13)

Sox14^Δ15

dendrite (with Sox14^Δ15)

Sox14^Δ13

dendrite | somatic clone

Sox14^Δ15

larval dorsal multidendritic neuron ddaC

Sox14^Δ13

larval dorsal multidendritic neuron ddaC, with Scer\GAL4²²¹

Sox14^fl.UAS

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

larval dorsal multidendritic neuron ddaC (with Df(2R)BSC136)

Sox14^Δ13

larval dorsal multidendritic neuron ddaC (with Df(2R)or-BR11)

Sox14^Δ15

larval dorsal multidendritic neuron ddaC (with Sox14^Δ13)

Sox14^Δ15

larval dorsal multidendritic neuron ddaC (with Sox14^Δ15)

Sox14^Δ13

larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone

Sox14^Δ13

larval dorsal multidendritic neuron ddaC | somatic clone

Sox14^Δ15

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Sox14^GD4416

wing, with Scer\GAL4^Bx-MS1096

Sox14^{UAS.ORF.GW.Tag:HA}

wing | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox14^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (36)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SOX12

8 of 15

Yes

Hsap\SOX4

7 of 15

Yes

Hsap\SOX14

5 of 15

Hsap\SOX17

5 of 15

Yes

5 of 15

4 of 15

4 of 15

4 of 15

4 of 15

Yes

Hsap\SOX21

4 of 15

Hsap\SOX1

3 of 15

Hsap\SOX11

3 of 15

Yes

Hsap\SRY

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\BHMG1

1 of 15

Yes

Hsap\CFAP65

1 of 15

Yes

Hsap\LDB3

1 of 15

Hsap\LPXN

1 of 15

Hsap\MIR6073

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (34)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Sox12

8 of 15

Yes

Mmus\Sox4

7 of 15

Yes

Mmus\Sox7

5 of 15

Mmus\Sox14

5 of 15

Mmus\Sox17

5 of 15

Yes

5 of 15

4 of 15

4 of 15

4 of 15

Yes

Mmus\Sox15

4 of 15

Yes

Mmus\Sox21

4 of 15

Mmus\Sry

4 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Mmus\Cfap65

1 of 15

Yes

Mmus\Gm4969

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (36)

Rnor\Sox12

6 of 13

Yes

Rnor\Sox2

4 of 13

Rnor\Sox7

4 of 13

Rnor\Sox11

4 of 13

Yes

Rnor\Sox14

4 of 13

Rnor\Sox17

4 of 13

Yes

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Rnor\LOC103694534

1 of 13

Yes

Rnor\LOC103694545

1 of 13

Yes

Rnor\LOC103694550

1 of 13

Yes

Rnor\LOC103694552

1 of 13

Yes

Rnor\LOC103694554

1 of 13

Yes

Rnor\LOC103694555

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Sox3

1 of 13

Yes

Rnor\Sox4

1 of 13

Yes

Rnor\Sox21

1 of 13

Yes

Rnor\Synpo2l

1 of 13

Rnor\Synpo2

1 of 13

Rnor\Tgfb1i1

1 of 13

Xenopus tropicalis (Western clawed frog) (28)

Xtro\sox7

5 of 12

Yes

Xtro\sox14

5 of 12

Yes

Xtro\sox17a

5 of 12

Yes

Xtro\sox17b.1

5 of 12

Yes

Xtro\sox17b.2

5 of 12

Yes

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\sox11

1 of 12

Yes

Xtro\sox15

1 of 12

Yes

Xtro\synpo2l

1 of 12

Xtro\tgfb1i1

1 of 12

Danio rerio (Zebrafish) (41)

Drer\sox4a

7 of 15

Yes

Drer\sox12

7 of 15

Yes

Drer\sox4b

6 of 15

Yes

Drer\sox11b

6 of 15

Yes

Drer\sox7

5 of 15

Drer\sox11a

5 of 15

Yes

Drer\sox14

5 of 15

Drer\sox17

5 of 15

Yes

Drer\sox18

5 of 15

Yes

Drer\sox2

4 of 15

Drer\sox3

4 of 15

Drer\sox19b

4 of 15

Yes

Drer\sox21a

4 of 15

Drer\sox21b

4 of 15

Drer\sox32

4 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch1073-349o24.2

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\sem-2

6 of 15

Yes

Cele\sox-3

6 of 15

Yes

4 of 15

4 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\Y1A5A.1

1 of 15

Cele\Y65B4A.7

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ROX1

5 of 15

Yes

Scer\LRG1

1 of 15

Scer\PXL1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\matmc_1

3 of 12

Yes

Spom\matmc_2

2 of 12

Yes

Spom\ste11

2 of 12

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919054F )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15918

Drosophila persimilis

Dper\GL11646

Drosophila willistoni

Dwil\GK10637

Drosophila virilis

Dvir\GJ21897

Drosophila mojavensis

Dmoj\GI20689

Drosophila grimshawi

Dgri\GH20178

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915090X )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021831

Glossina morsitans

Tsetse fly

Gmor\GMOY010876

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08692

Mayetiola destructor

Hessian fly

Mdes\Mdes004165

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011831

Anopheles gambiae

Malaria mosquito

Agam\AGAP005183

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014423

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09X2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004151

Danaus plexippus

Monarch butterfly

Dple\DPOGS209911-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008012

Apis florea

Little honeybee

Aflo\2154237604

Apis mellifera

Western honey bee

Amel\GB45639

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18924

Bombus terrestris

Buff-tailed bumblebee

Bter\15216539

Linepithema humile

Argentine ant

Lhum\LH12022

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0026c7

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003506

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05368

Tribolium castaneum

Red flour beetle

Tcas\TC008936

Pediculus humanus

Human body louse

Phum\PHUM199330

Cimex lectularius

Bed bug

Clec\CLEC005968

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI22575

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04641

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09SW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR010316

Ixodes scapularis

Black-legged tick

Isca\ISCW015396

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81034.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81033.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62555.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur03g02300

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_199562

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_39527

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0FFO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-SoxC

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

6 of 10

6 of 10

5 of 10

5 of 10

5 of 10

3 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Pax

1 of 10

Zasp52

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

SOX17; SRY-box transcription factor 17

model of vesicoureteral reflux

IEA

(FlyBase, 2019-)

SOX11; SRY-box transcription factor 11

model of Coffin-Siris syndrome 9

IEA

(FlyBase, 2019-)

SRY; sex determining region Y

model of 46,XY sex reversal 1

IEA

(FlyBase, 2019-)

model of 46,XX sex reversal 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Sox14^UAS.cRa

ameliorates frontotemporal dementia

modeled by TER94^{E375Q.E575Q.UAS}

(Rumpf et al., 2014)

ameliorates amyotrophic lateral sclerosis type 14

modeled by TER94^{E375Q.E575Q.UAS}

(Rumpf et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOX12; SRY-box transcription factor 12

8 of 15

601947

SOX4; SRY-box transcription factor 4

7 of 15

184430

COFFIN-SIRIS SYNDROME 10; CSS10

SOX14; SRY-box transcription factor 14

5 of 15

604747

SOX17; SRY-box transcription factor 17

5 of 15

610928

VESICOURETERAL REFLUX 3; VUR3

vesicoureteral reflux

SOX18; SRY-box transcription factor 18

5 of 15

601618

SOX2; SRY-box transcription factor 2

4 of 15

184429

MICROPHTHALMIA, SYNDROMIC 3; MCOPS3

syndromic microphthalmia 3

SOX3; SRY-box transcription factor 3

4 of 15

313430

X-linked panhypopituitarism

SOX7; SRY-box transcription factor 7

4 of 15

612202

SOX15; SRY-box transcription factor 15

4 of 15

601297

SOX21; SRY-box transcription factor 21

4 of 15

604974

SOX1; SRY-box transcription factor 1

3 of 15

602148

SOX11; SRY-box transcription factor 11

3 of 15

600898

COFFIN-SIRIS SYNDROME 9; CSS9

Coffin-Siris syndrome 9

SRY; sex determining region Y

3 of 15

480000

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sox14 - CrebA

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Sox14

suppressible

Mical

(Kirilly et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

EcR

suppressible

Sox14

(Kirilly et al., 2009)

Mical

suppressible

Sox14

(Kirilly et al., 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63408

DroID - A comprehensive database of gene and protein interactions.

FBgn0005612

MIST (protein-protein) - An integrated Molecular Interaction Database

Sox14

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-105

Cytogenetic map

60A16-60A16

Sequence location

2R:23,978,801..23,985,177 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A16-60A16

Limits computationally determined from genome sequence between P{EP}Tal^EP489&P{EP}CG3065^EP316 and P{lacW}Phm^k07623&P{lacW}tsr^k05633

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60A8-60B8

(determined by in situ hybridisation)

(Sparkes et al., 2001)

60B1-60B2

(Girad, 1999.12.21, Sparkes et al., 1997)

Experimentally Determined Recombination Data

Location

2-105

(FlyBase, 2016)

2-109.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

55842

w¹¹¹⁸; PBac{Sox14-GFP.FPTB}VK00033

26221

y¹ v¹; P{TRiP.JF02119}attP2

27971

y¹ w^*; P{EP}Sox14^G7900

59638

y¹ w^*; Mi{MIC}Sox14^MI14824

78987

y¹ w^*; TI{CRIMIC.TG4.0}Sox14^{CR00691-TG4.0}/SM6a

79510

y¹ sc^* v¹ sev²¹; P{TOE.GS02048}attP40

34794

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00103}attP2

FlyORF

F000654

M{UAS-Sox14.ORF.3xHA.GW}ZH-86Fb

F004873

M{UAS-Sox14.ORF-VNshort}ZH-86Fb

VDRC

v107146

P{KK107471}VIE-260B

v10856

w¹¹¹⁸; P{GD4416}v10856/TM3

v342098

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01562}attP40/CyO-GFP

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP08830

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0005612

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0005612

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37822

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ritter and Beckstead, 2010, Kirilly et al., 2009, Sparkes et al., 2001)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Sox14 CG3090

(Wang, 1999.11)

Source for database merge of

Source for merge of: Sox14 CG17263

(Whitfield, 2000.8.29)

Additional comments

l(2)k06608b may correspond to Sox14: the P{lacW}l(2)k06608b^k06608b insertion maps within the transcription unit.

(Gene Disruption Project members, 2015.10.8)

Release 1 annotation CG17263 contained sequences corresponding to both of the release 3.2 annotations CG3090 (Sox14) and CG30178.

(FlyBase, 1996-)

Other Comments

Area matching Drosophila EST AA950164.

(Davies, 2001.3.15)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37822

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P40656

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LGC4

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005612

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0005612

DRscDB

37822/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0005612

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Flygut - An atlas of the Drosophila adult midgut

FBgn0005612

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37822

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008936

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3090

MARRVEL_MODEL

37822

modMine - A data warehouse for the modENCODE project

FBgn0005612

Linkouts

BioGRID - A database of protein and genetic interactions.

63408

DroID - A comprehensive database of gene and protein interactions.

FBgn0005612

DRSC - Results frm RNAi screens

FBgn0005612

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3090-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0005612

FlyMine - An integrated database for Drosophila genomics

FBgn0005612

MIST (protein-protein) - An integrated Molecular Interaction Database

Sox14

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG17263

(Kashevsky et al., 2002, Jiang et al., 2000, Whitfield, 2000.8.29)

CG3090

(Neuert et al., 2017, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Lee et al., 2003, Kashevsky et al., 2002, Cremazy et al., 2001, Taghert, 2000.4.2)

DSox-14

(Denny et al., 1992)

DSox14

(Sparkes et al., 2001, Crane-Robinson, 2000.5.27)

DSox60B

(Sparkes et al., 1997)

Dsox-14

(Denny, 1992.4.23)

SOX14

(Yang et al., 2012, Bowles et al., 2000)

SOX60B

(Bowles et al., 2000)

SOXC

(Bowles et al., 2000)

Sox-14

(Yaniv and Schuldiner, 2016)

sox14

(Keder et al., 2020, Xu et al., 2020, Zhu et al., 2019, Wong et al., 2013, Awofala et al., 2012, Kirilly et al., 2011, Ritter and Beckstead, 2010, Kirilly et al., 2009, Foglietti et al., 2006, Beckstead et al., 2005)

Name Synonyms

Sox box protein 14

sox box protein 14

(Beckstead et al., 2005)

Secondary FlyBase IDs

FBgn0034949

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (93)

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