FlyBase Gene Report: Dmel\Psc

General Information

Symbol

Dmel\Psc

Species

D. melanogaster

Name

Posterior sex combs

Annotation Symbol

CG3886

Feature Type

protein_coding_gene

FlyBase ID

FBgn0005624

Gene Model Status

Current

Stock Availability

25 publicly available

Gene Snapshot

Posterior sex combs (Psc) was originally identified as a member of the Polycomb group of genes that regulate gene expression through epigenetic marks. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Posterior sex comb, l(2)49Ea

Key Links

Genomic Location

Cytogenetic map

49E6-49E6

Sequence location

2R:12,965,997..12,980,994 [-]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12965997..12980994

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(Enderle et al., 2011)

enables DNA binding

inferred from direct assay

(Lo et al., 2009)

enables sequence-specific DNA binding

inferred from direct assay

(Ogiyama et al., 2018)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables promoter-specific chromatin binding

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(assigned by GO_Central )

(Gaudet et al., 2011)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from direct assay

(Francis et al., 2001)

involved_in chromatin silencing

inferred from direct assay

(Lo et al., 2009)

involved_in negative regulation of gene expression

inferred from mutant phenotype

(Nishioka et al., 2018)

involved_in syncytial blastoderm mitotic cell cycle

inferred from mutant phenotype

(O'Dor et al., 2006)

involved_in ventral cord development

inferred from high throughput mutant phenotype

(Bivik et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chromatin silencing

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in histone H2A-K119 monoubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Mulholland et al., 2003, Martin and Adler, 1993)

part_of PcG protein complex

inferred from direct assay

(Lagarou et al., 2008)

located_in polytene chromosome band

inferred from direct assay

(Brown and Kassis, 2010)

part_of PRC1 complex

inferred from direct assay

(Mulholland et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of PRC1 complex

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(assigned by GO_Central )

(Gaudet et al., 2011)

traceable author statement

(Levine et al., 2004)

Gene Group (FlyBase)

dRING-ASSOCIATED FACTORS

POLYCOMB REPRESSIVE COMPLEX 1 (CORE SUBUNITS)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

dRING-ASSOCIATED FACTORS -: The Drosophila Polycomb group complex dRING-associated factors (dRAF) catalyzes histone H2A K119 ubiquitination and H3K36me2 removal. Therefore, dRAF removes an active mark from histone H3 and adds a repressive one to H2A. (Adapted from FBrf0215737).
POLYCOMB REPRESSIVE COMPLEX 1 (CORE SUBUNITS) -: The Polycomb repressive complex 1 (PRC1) is a Polycomb group complex. It binds to histone H3K27me3 (histone H3 K27 methylation is catalyzed by PRC2) and monoubiquitinates H2A on K119. This leads to chromatin compaction, RNA polymerase II stalling and gene silencing. (Adapted from FBrf0179742 and FBrf0228921).

Protein Function (UniProtKB)

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.

(UniProt, P35820)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Psc: Posterior sex combs

Psc+ is another gene that may be considered a negative regulator of the BXC or the ANTC. The mutant is homo- and hemizygous lethal, the embryos showing partial transformation of head and thorax into abdomen and of abdominal segments 1-7 into more posterior ones. Psc/Psc embryos that are also homozygous for Asx, Pcl, or Scm show stronger posteriorly-directed transformations; the triple mutant Psc Asx Pcl has a tandem array of posterior abdominal segments including four abdominal denticle bands in the head region (Jurgens, 1985). Psc/+ males may have sex combs on second and third legs. The gene suppresses z1 eye color, which becomes orange-maroon; it is lethal with Su(z)21 and Su(z)25 and semiviable with Su(z)24 (Wu et al., 1989). Psc and Su(z)2 are both members of the Su(z)2 complex.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Psc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.49

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Psc-RA

FBtr0087798

NM_079001

6007

1601

Psc-RB

FBtr0345196

NM_001299439

5671

1601

Psc-RC

FBtr0345375

NM_001299440

6332

1601

Additional Transcript Data and Comments

Reported size (kB)

6.0 (longest cDNA)

(Brunk et al., 1991)

6.6 (northern blot)

(van Lohuizen et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Psc-PA

FBpp0086911

169.8

1601

10.41

NP_523725

AAF58434

Psc-PB

FBpp0311395

169.8

1601

10.41

NP_001286368

AHN56166

Psc-PC

FBpp0311526

169.8

1601

10.41

NP_001286369

AHN56167

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1601 aa isoforms: Psc-PA, Psc-PB, Psc-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

1603 (aa)

(Brunk et al., 1991)

Comments

External Data

Subunit Structure (UniProtKB)

Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1-55. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.

(UniProt, P35820)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Psc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Psc_1
Psc_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Martin and Adler, 1993)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

ovary

(Martin and Adler, 1993)

third instar larval stage

imaginal disc

(Martin and Adler, 1993)

embryonic/larval central nervous system

(Martin and Adler, 1993)

pupal stage P6

adult brain

Comment: reference states 24 hr APF

(Martin and Adler, 1993)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

imaginal disc

(Martin and Adler, 1993)

embryonic/larval salivary gland

(Martin and Adler, 1993)

first instar larval stage

embryonic/larval brain

(Martin and Adler, 1993)

ventral nerve cord

(Martin and Adler, 1993)

embryonic stage

primordial germ cell

(Martin and Adler, 1993)

central nervous system

(Martin and Adler, 1993)

Additional Descriptive Data

The Psc protein localizes to the nucleus.

(Martin and Adler, 1993)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Mulholland et al., 2003, Martin and Adler, 1993)

part_of PcG protein complex

inferred from direct assay

(Lagarou et al., 2008)

located_in polytene chromosome band

inferred from direct assay

(Brown and Kassis, 2010)

part_of PRC1 complex

inferred from direct assay

(Mulholland et al., 2003)

Expression Deduced from Reporters

Reporter: P{M2ET-QF}ET40

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

glial cell | subset

(Potter et al., 2010)

neuron | subset

(Potter et al., 2010)

larval stage

eye-antennal disc

(Potter et al., 2010)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Psc in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Psc

View exonic expression by tissue for Dmel\Psc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0005624

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3886-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0005624

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 47 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Psc

Transgenic constructs containing regulatory region of Psc

Aberrations (Deficiencies and Duplications) ( 41 )

Inferred from experimentation

Gene disrupted in

Df(2R)Arp1.Fbf1a

(Brunk et al., 1991, Adler et al., 1989)

Df(2R)CX1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Exel7123

(Ryder, 2004.4.26)

Df(2R)P3C

(Classen et al., 2009)

Df(2R)R7

(Lasko and Pardue, 1988)

Df(2R)Su(z)2-1.a6

(Wu and Howe, 1995)

Df(2R)Su(z)2-1.b8

(Soto et al., 1995, Wu and Howe, 1995, Cheng et al., 1994, Brunk et al., 1991, Adler et al., 1989)

Df(2R)Su(z)2⁵

(Muller et al., 1999, Wu and Howe, 1995)

Df(2R)Su(z)3-1.iy

(Wu and Howe, 1995)

Df(2R)Su(z)3-1.jtg

(Wu and Howe, 1995)

Df(2R)Su(z)3^1.y

(Brunk et al., 1991)

Df(2R)vg33

(Lasko and Pardue, 1988)

Df(2R)vg56

(Lasko and Pardue, 1988)

Df(2R)vg62

(Wu and Howe, 1995, Brunk et al., 1991, Adler et al., 1989, Lasko and Pardue, 1988)

Df(2R)vg79b3

(Lasko and Pardue, 1988)

Df(2R)vg79d8

(Lasko and Pardue, 1988)

Df(2R)vg81

(Lasko and Pardue, 1988)

Df(2R)vg83f15

(Lasko and Pardue, 1988)

Df(2R)vg104

(Lasko and Pardue, 1988)

Df(2R)vg106

(Lasko and Pardue, 1988)

Df(2R)vg107

(Pauli et al., 1995, Lasko and Pardue, 1988)

Df(2R)vg120

(Lasko and Pardue, 1988)

Df(2R)vg124

(Lasko and Pardue, 1988)

Df(2R)vg136

(Pauli et al., 1995, Lasko and Pardue, 1988)

Df(2R)vg-B

(Spradling et al., 1999, Harbecke and Lengyel, 1995, Wu and Howe, 1995, BDGP Project Members, 1994-1999, Cheng et al., 1994, Simon et al., 1992, Adler et al., 1989, Lasko and Pardue, 1988, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)

Df(2R)vg-D

(Wu and Howe, 1995, BDGP Project Members, 1994-1999, Adler et al., 1989, Lasko and Pardue, 1988, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)

Df(2R)vg-P2

(Lasko and Pardue, 1988)

Df(2R)XL26

(Li et al., 2010)

In(2LR)vg^79a

(Lasko and Pardue, 1988)

T(2;3)Psc^1.d20

(Wu and Howe, 1995, Brunk et al., 1991)

T(2;4)Psc^1.d21

(Wu and Howe, 1995)

Gene not disrupted in

Df(2R)03072

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)vg133

(Lasko and Pardue, 1988)

Df(2R)vg135

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Lasko and Pardue, 1988)

Df(2R)vg-C

(Wu and Howe, 1995, BDGP Project Members, 1994-1999, Lasko and Pardue, 1988, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)

In(2R)Arp1

(Adler, 1995.3.28)

T(2;3)Su(z)2^1.a1

(Wu and Howe, 1995)

Gene duplicated in

Ts(2Lt;3Rt)BTD20+Ts(3Lt;2Rt)BTD14

(Wu and Howe, 1995)

Ts(2Lt;3Rt)BTD20+Ts(3Lt;2Rt)BTD71

(Wu and Howe, 1995)

Ts(2Lt;3Rt)BTD24+Ts(3Lt;2Rt)BTD14

(Wu and Howe, 1995)

Ts(2Lt;3Rt)BTD24+Ts(3Lt;2Rt)BTD71

(Wu and Howe, 1995)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of larval stage | recessive

Psc^Arp.1

lethal - all die during embryonic stage | recessive

partially lethal - majority die | recessive

viable

Psc^CB05083

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Psc^GD4481

viable, with Scer\GAL4^Mef2.PR

Psc^GD4481

viable, with Scer\GAL4^pnr-MD237

Psc^GD4481

viable, with Scer\GAL4^tin.CΔ4

Psc^GD4481

Other Phenotypes

Allele

abnormal eye color | dominant

abnormal mitotic cell cycle | embryonic stage

abnormal neuroanatomy

homeotic

Psc¹

increased cell number | adult stage | female, with Scer\GAL4^C587

Psc^{N1.UAS.Tag:MYC}

long lived | dominant

Psc^c364

neoplasia | adult stage | female, with Scer\GAL4^C587

Psc^{N1.UAS.Tag:MYC}

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

Psc¹

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

Psc¹

non-suppressor of variegation | dominant, with In(1)w^m4

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

some die during embryonic stage | recessive

some die during larval stage | recessive

Psc^Arp.1

suppressor of variegation, with P{hsp26-pt-T}39C-5

suppressor of variegation, with P{hsp26-pt-T}39C-27

suppressor of variegation, with P{hsp26-pt-T}39C-31

suppressor of variegation, with P{hsp26-pt-T}39C-50

suppressor of variegation, with P{hsp26-pt-T}39C-51

suppressor of variegation, with P{hsp26-pt-T}39C-58

suppressor of variegation, with P{hsp26-pt-T}39C-62

suppressor of variegation, with P{hsp26-pt-T}118E-16

suppressor of variegation, with P{hsp26-pt-T}118E-26

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-27

Psc¹

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-31

Psc¹

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69

Psc¹

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M1

Psc¹

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M2

Psc¹

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M3

Psc¹

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M10

Psc¹

suppressor of variegation | dominant, with P{wA}4-4

Psc¹

visible, with Scer\GAL4^Bx-MS1096

Psc^{UAS.ORF.GW.Tag:HA}

visible | adult stage, with Scer\GAL4^en.PU

Psc^GD4481

visible | adult stage, with Scer\GAL4^GMR.PF

Psc^GD4481

visible | cold sensitive, with Scer\GAL4^Bx-MS1096

Psc^{UAS.ORF.GW.Tag:HA}

visible | dominant

visible | dominant | homeotic

Psc¹

visible | somatic clone

Phenotype manifest in

Allele

abdomen & macrochaeta

Psc^hs.PS

alula

anaphase | embryonic stage

apterous-expressing neuron of the lateral cluster of the thorax

apterous-expressing neuron of the lateral cluster of the thorax Ap4

costal vein & macrochaeta

Psc^hs.PS

denticle belt

dorsal double row & macrochaeta

Psc^hs.PS

dorsal triple row & macrochaeta

Psc^hs.PS

embryonic abdomen

Psc¹

embryonic epidermis

Psc^Arp1

embryonic head

Psc¹

embryonic thorax

Psc¹

eye, with Scer\GAL4^GMR.PF

Psc^GD4481

germarium, with Scer\GAL4^C587

Psc^{N1.UAS.Tag:MYC}

head & macrochaeta

Psc^hs.PS

leg & macrochaeta

Psc^hs.PS

macrochaeta

mesothoracic leg

Psc¹

mesothoracic leg & sex comb tooth | ectopic

Psc¹

metathoracic leg

Psc¹

metathoracic leg & sex comb tooth | ectopic

Psc¹

pigment cell

posterior crossvein, with Scer\GAL4^en.PU

Psc^GD4481

scutellum & macrochaeta

Psc^hs.PS

scutum & macrochaeta

Psc^hs.PS

sex comb

Psc¹

sex comb | ectopic

Psc¹

sex comb | increased number

Psc¹

sex comb tooth | ectopic

Psc¹

telophase | embryonic stage

ventral double row & macrochaeta

Psc^hs.PS

ventral triple row & macrochaeta

Psc^hs.PS

wing, with Scer\GAL4^Bx-MS1096

Psc^{UAS.ORF.GW.Tag:HA}

wing | cold sensitive, with Scer\GAL4^Bx-MS1096

Psc^{UAS.ORF.GW.Tag:HA}

wing | somatic clone

wing blade posterior compartment

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BMI1

6 of 15

Yes

Hsap\COMMD3-BMI1

5 of 15

Yes

Hsap\PCGF1

5 of 15

Yes

Hsap\PCGF2

5 of 15

Yes

Hsap\PCGF5

5 of 15

Yes

Hsap\PCGF3

3 of 15

Hsap\PCGF6

3 of 15

Yes

Hsap\RING1

1 of 15

Hsap\RNF2

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Bmi1

7 of 15

Yes

Mmus\Pcgf2

5 of 15

Yes

Mmus\Pcgf5

5 of 15

Yes

Mmus\Pcgf1

4 of 15

Yes

Mmus\Pcgf6

3 of 15

Yes

Mmus\Pcgf3

2 of 15

Mmus\Ring1

1 of 15

Mmus\Rnf2

1 of 15

Rattus norvegicus (Norway rat) (11)

Rnor\Bmi1

5 of 13

Yes

Rnor\Pcgf1

5 of 13

Yes

Rnor\Pcgf2

5 of 13

Yes

Rnor\RGD1562871

5 of 13

Yes

Rnor\LOC103692167

4 of 13

Yes

Rnor\Pcgf5

4 of 13

Yes

Rnor\Pcgf3

3 of 13

Rnor\Pcgf6

3 of 13

Yes

Rnor\LOC103692755

1 of 13

Yes

Rnor\Ring1

1 of 13

Rnor\Rnf2

1 of 13

Xenopus tropicalis (Western clawed frog) (9)

Xtro\bmi1

6 of 12

Yes

Xtro\pcgf2

5 of 12

Yes

Xtro\pcgf3

3 of 12

Xtro\pcgf6

3 of 12

Yes

Xtro\LOC101734120

2 of 12

Yes

Xtro\pcgf5

2 of 12

Yes

Xtro\pcgf1

1 of 12

Yes

Xtro\ring1

1 of 12

Xtro\rnf2

1 of 12

Danio rerio (Zebrafish) (8)

Drer\bmi1a

7 of 15

Yes

Drer\bmi1b

7 of 15

Yes

Drer\pcgf1

5 of 15

Yes

Drer\pcgf5a

4 of 15

Drer\pcgf5b

4 of 15

Drer\pcgf6

3 of 15

Yes

Drer\pcgf3

2 of 15

Yes

Drer\rnf2

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\mig-32

4 of 15

Yes

Cele\spat-3

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\RAD18

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904S4 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17752

Drosophila persimilis

Dper\GL10594

Drosophila willistoni

Dwil\GK20868

Drosophila virilis

Dvir\GJ21143

Drosophila mojavensis

Dmoj\GI19568

Drosophila grimshawi

Dgri\GH23673

Drosophila grimshawi

Dgri\GH21599

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502M4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17005470

Glossina morsitans

Tsetse fly

Gmor\GMOY008708

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02791

Mayetiola destructor

Hessian fly

Mdes\Mdes005930

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011178

Anopheles darlingi

American malaria mosquito

Adar\ADAC007247

Anopheles gambiae

Malaria mosquito

Agam\AGAP006403

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ015235

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019246

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06BU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006194

Danaus plexippus

Monarch butterfly

Dple\DPOGS214148-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016407

Apis florea

Little honeybee

Aflo\3049298708

Apis florea

Little honeybee

Aflo\2276640244

Apis mellifera

Western honey bee

Amel\LOC413984

Apis mellifera

Western honey bee

Amel\GB48263

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23470

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22517

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15283

Bombus terrestris

Buff-tailed bumblebee

Bter\15208602

Bombus terrestris

Buff-tailed bumblebee

Bter\15210160

Linepithema humile

Argentine ant

Lhum\LH24067

Linepithema humile

Argentine ant

Lhum\LH14628

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0018d2

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0017c6

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006760

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011952

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06532

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11490

Tribolium castaneum

Red flour beetle

Tcas\TC034738

Tribolium castaneum

Red flour beetle

Tcas\TC005337

Tribolium castaneum

Red flour beetle

Tcas\TC004246

Pediculus humanus

Human body louse

Phum\PHUM193850

Pediculus humanus

Human body louse

Phum\PHUM328750

Pediculus humanus

Human body louse

Phum\PHUM328760

Rhodnius prolixus

Kissing bug

Rpro\RPRC013403

Rhodnius prolixus

Kissing bug

Rpro\RPRC001618

Cimex lectularius

Bed bug

Clec\CLEC000889

Cimex lectularius

Bed bug

Clec\CLEC001939

Cimex lectularius

Bed bug

Clec\CLEC000888

Cimex lectularius

Bed bug

Clec\CLEC000886

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003133

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003305

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003920

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09507

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01512

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09508

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X067F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009966

Strigamia maritima

European centipede

Smar\SMAR009971

Ixodes scapularis

Black-legged tick

Isca\ISCW013208

Ixodes scapularis

Black-legged tick

Isca\ISCW022410

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62825.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63569.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g08830

Tetranychus urticae

Two-spotted spider mite

Turt\tetur25g00130

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_8025

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_302409

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09IB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bmi1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bmi1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018033

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000002776

Gallus gallus

Domestic chicken

Ggal\PCGF2

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026623

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

5 of 10

4 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, epigenetic mechanisms

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Psc^k07834

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN8OS^CTG112.UAS

(Mutsuddi et al., 2004)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BMI1; BMI1 proto-oncogene, polycomb ring finger

6 of 15

164831

COMMD3-BMI1; COMMD3-BMI1 readthrough

5 of 15

PCGF1; polycomb group ring finger 1

5 of 15

610231

PCGF2; polycomb group ring finger 2

5 of 15

600346

TURNPENNY-FRY SYNDROME; TPFS

PCGF5; polycomb group ring finger 5

5 of 15

617407

PCGF3; polycomb group ring finger 3

3 of 15

617543

PCGF6; polycomb group ring finger 6

3 of 15

607816

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Psc

pull down, autoradiography, cross-linking study, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Lo et al., 2012, Kyba and Brock, 1998)

Psc - Br140

cross-linking study, tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2017)

Psc - Cdc23

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Mohd-Sarip et al., 2012)

Psc - Cdk1

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Mohd-Sarip et al., 2012)

Psc - CycB

pull down, western blot, enzymatic study, anti bait coimmunoprecipitation, Identification by mass spectrometry, autoradiography

(Mohd-Sarip et al., 2012)

Psc - Kdm2

anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining

(Fereres et al., 2014, Lagarou et al., 2008)

Psc - Mtor

anti bait coimmunoprecipitation, western blot

(Lagarou et al., 2008)

Psc - RAF2

anti bait coimmunoprecipitation, western blot

(Lagarou et al., 2008)

Psc - RYBP

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Psc - Sce

anti tag coimmunoprecipitation, molecular weight estimation by staining, cross-linking study, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot, affinity chromatography technology, peptide massfingerprinting, pull down, autoradiography

(Kang et al., 2020, Kang et al., 2017, Fereres et al., 2014, Mohd-Sarip et al., 2012, Lagarou et al., 2008, Gorfinkiel et al., 2004, Peterson et al., 2004)

Psc - Scm

tandem affinity purification, Identification by mass spectrometry, molecular sieving, western blot, anti tag coimmunoprecipitation, molecular weight estimation by staining

(Kang et al., 2015, Peterson et al., 2004, Shao et al., 1999)

Psc - Taf4

anti bait coimmunoprecipitation, western blot

(Saurin et al., 2001)

Psc - Taf5

anti bait coimmunoprecipitation, western blot

(Saurin et al., 2001)

Psc - Taf9

anti bait coimmunoprecipitation, western blot

(Saurin et al., 2001)

Psc - Tbp

anti bait coimmunoprecipitation, western blot

(Breiling et al., 2001, Saurin et al., 2001)

Psc - Ulp1

anti bait coimmunoprecipitation, western blot

(Lagarou et al., 2008)

Psc - cg

anti bait coimmunoprecipitation, western blot

(Ray et al., 2016)

Psc - fs(1)h

cross-linking study, tandem affinity purification, Identification by mass spectrometry, anti tag coimmunoprecipitation, molecular weight estimation by staining, western blot

(Kang et al., 2017)

Psc - lmgA

anti bait coimmunoprecipitation, western blot, pull down, autoradiography, Identification by mass spectrometry

(Mohd-Sarip et al., 2012)

Psc - mr

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Mohd-Sarip et al., 2012)

Psc - nej

anti bait coimmunoprecipitation, western blot

(Tie et al., 2016)

Psc - ph-d

anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry, anti tag coimmunoprecipitation, molecular weight estimation by staining, peptide massfingerprinting

(Kang et al., 2017, Frey et al., 2016, Fereres et al., 2014, Gambetta and Müller, 2014, Mohd-Sarip et al., 2012, Lagarou et al., 2008, Lupo et al., 2001)

Psc - vtd

anti tag coimmunoprecipitation, western blot

(Strübbe et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2016)

suppressible

(Li et al., 2016)

suppressible

(Campbell et al., 1995)

suppressible

(Li et al., 2016)

enhanceable

(Nishioka et al., 2018)

Psc

suppressible

esc

(Campbell et al., 1995)

Psc

suppressible

Marcal1

(Morimoto et al., 2016)

Psc

enhanceable

mbf1

(Nishioka et al., 2018)

Psc

enhanceable

mbf1|pcm

(Nishioka et al., 2018)

Psc

enhanceable

mxc

(Docquier et al., 1996)

Psc

suppressible

pcm

(Nishioka et al., 2018)

Psc|mbf1

suppressible

pcm

(Nishioka et al., 2018)

Psc

enhanceable

pcm

(Nishioka et al., 2018)

Psc

enhanceable

psq

(Huang et al., 2002)

Psc

suppressible

Sce

(Sharp et al., 1994)

enhanceable

(Li et al., 2016)

suppressible

(Schaaf et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ash1|trx

suppressible

Psc

(Gildea et al., 2000)

ash1|trx

enhanceable

Psc

(Gildea et al., 2000)

brm|trx

enhanceable

Psc

(Gildea et al., 2000)

enhanceable

Psc

(Randsholt et al., 2000)

suppressible

Psc

(Krupp et al., 2005, Melnikova et al., 1996)

enhanceable

Psc

(Krupp et al., 2005)

E(z)

enhanceable

Psc

(Bajusz et al., 2001)

E(z)

suppressible

Psc

(Bajusz et al., 2001)

enhanceable

Psc

(Randsholt et al., 2000)

Marcal1

suppressible

Psc

(Morimoto et al., 2016)

mxc

enhanceable

Psc

(Saget et al., 1998, Docquier et al., 1996)

Sce

enhanceable

Psc

(Adler et al., 1991)

suppressible

Psc

(Bantignies et al., 2003)

Su(z)2

enhanceable

Psc

(Li et al., 2016)

suppressible

Psc

(Bloyer et al., 2003, Tillib et al., 1999, Netter et al., 1998)

enhanceable

Psc

(Bloyer et al., 2003)

suppressible

Psc

(Wu and Howe, 1995, Martin and Adler, 1993, Brunk et al., 1991, Brunk and Adler, 1990)

External Data

Subunit Structure (UniProtKB)

(UniProt, P35820 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62201

DroID - A comprehensive database of gene and protein interactions.

FBgn0005624

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36431

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-67

Cytogenetic map

49E6-49E6

Sequence location

2R:12,965,997..12,980,994 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49E6-49E6

Limits computationally determined from genome sequence between P{PZ}l(2)01424⁰¹⁴²⁴ and P{lacW}Psc^k07834&P{lacW}Su(z)2^k06344

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49E6-49E7

(determined by in situ hybridisation)

(Spradling et al., 1999)

49E-49E

(determined by in situ hybridisation)

(Brunk et al., 1991, van Lohuizen et al., 1991)

Experimentally Determined Recombination Data

Location

2-67

(FlyBase, 2016, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)

2-71.3

(Comeron et al., 2012)

2-67.5

(Wu and Howe, 1995)

Left of (cM)

(Wu and Howe, 1995)

Right of (cM)

(Wu and Howe, 1995)

Notes

Mapping based on 234 recombinants of Psc¹. Homeotic and eye color effects cosegregate among 110 recombinants in the Bl-L interval.

(Wu and Howe, 1995)

Stocks and Reagents

Stocks (25)

Bloomington

5546

Psc^e22/CyO

5547

Psc^h27/CyO

68152

w^*; P{UAS-Psc.N1.Myc}2

31611

y¹ v¹; P{TRiP.JF01395}attP2

10688

y¹ w^67c23; P{lacW}Psc^k07834/CyO

68225

w^*; P{UAS-Psc.N1.Myc}2, P{UAS-Su(z)2.N1.Myc}2/CyO

Kyoto

108290

Psc^e22/CyO

108291

Psc^h27/CyO

123906

w¹¹¹⁸; P{RS3}Psc^CB-6084-3

105911

Df(2R)vg-D, Psc^vgD Su(z)2^vgD/SM5

VDRC

v30586

w¹¹¹⁸; P{GD4481}v30586

v30587

w¹¹¹⁸; P{GD4481}v30587

More stocks available...

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP14548

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0005624

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LP13683

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0005624

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36431

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Francis et al., 2009, Lagarou et al., 2008)

monoclonal, polyclonal

(Martin and Adler, 1993)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

A member of the Su(z)2 complex.

(Wu et al., 1989)

Other Comments

Psc on its own is able to inhibit chromatin remodelling in vitro.

(Francis et al., 2001)

Pc, Scm, Psc, ph-p and ph-d contribute to the PRC1 (Polycomb repressive complex 1). PRC1 directly antagonizes ATP-dependent remodeling of nucleosomal arrays in a purified system and may directly modulate (and be modified by) SWI/SNF (brm/mor) activity.

(Shao et al., 1999)

ph-p, Psc and Pc proteins coimmunoprecipitate from nuclear extracts. Interacting domains are identified and delimited using the two-hybrid system, the interactions are shown to be direct by using an in vitro binding assay.

(Kyba and Brock, 1998)

Psc protein coimmunoprecipitates Pc and ph-d/ph-p indicating they are members of a common multimeric protein complex. These proteins are associated with identical regulatory elements of en and differentially distributed on regulatory sequences of inv.

(Strutt and Paro, 1997)

Asx, Pc, Pcl, Psc, Scm and Sce have similar functions in some imaginal tissues.

(Campbell et al., 1995)

Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model.

(Campbell et al., 1995)

Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.

(Gindhart and Kaufman, 1995)

Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.

(Soto et al., 1995)

The mutant phenotypes of Psc, Su(z)2 and Su(z)3, the similarities of the phenotypes and the mutational interactions between them suggest that the products are functionally similar and act at the level of chromatin, possibly as a multimeric complex.

(Wu and Howe, 1995)

The alleles of Psc define two overlapping phenotypic classes, the 'hopeful' and the 'hapless' alleles.

(Wu and Howe, 1995)

The distinction between 'hopeful' and 'hapless' alleles and intragenic complementation seen among some Psc alleles are consistent with a multidomain structure for the Psc product.

(Wu and Howe, 1995)

Members of the Pc group function as potent repressors in mammalian cells.

(Bunker and Kingston, 1994)

Psc is one of several Pc-G genes required for the repression of gap genes by maternally supplied hb product.

(Pelegri and Lehmann, 1994)

Psc is not essential for normal bristle differentiation.

(Sharp et al., 1994)

Mutations in Psc generate malformations of the longitudinal tracts.

(Jacobs, 1993)

Psc binds polytene chromosomes at 45 locations where other Pc-group proteins, encoded by the Pc and ph-d/ph-p genes, are present.

(Martin and Adler, 1993)

Molecular analysis revealed similarity to the murine oncogene bmi-1.

(Martin and Adler, 1993)

Maternal rescue explains the lack of a segmental transformation mutant phenotype in embryos.

(Martin and Adler, 1993)

Psc and Su(z)2 gene products are nuclear proteins and are associated with more than 80 sites in the salivary gland polytene chromosomes. There is considerable overlap with the sites that are bound by antibodies to z, Pc and the ph-d/ph-p proteins.

(Rastelli et al., 1993)

The association of the Psc and Su(z)2 proteins with the chromosomes is dependent on the presence of active E(z) protein.

(Rastelli et al., 1993)

The bithorax complex genes are regulated by the Pc group of genes, acting via 'Pc group response elements' (PREs), that can work even when removed from the normal the bithorax complex context. The Pc group products apparently provide stable memory or imprinting of boundaries which are specified by gap and pair-rule regulators.

(Simon et al., 1993)

A member of the Polycomb group of genes. May be considered a negative regulator of the BXC or the ANTC.

(Lindsley and Zimm, 1992)

The mutant is homo- and hemizygous lethal, the embryos showing partial transformation of head and thorax into abdomen and of abdominal segments 1-7 into more posterior ones. Psc¹/Psc¹ embryos that are also homozygous for Asx¹, Pcl¹, or Scm¹ show stronger posteriorly-directed transformations; Psc¹/+ males may have sex combs on second and third legs. Viability reduced in transheterozygotes in some Psc¹/Su(z)2 combinations, lethal in others.

(Lindsley and Zimm, 1992)

Embryos mutant for two or more Pc-group genes (Pc, Scm, Pcl, Psc, Asx, E(Pc), E(z), ph-d, pho and esc) show strong ectopic en expression, but only weak derepression occurs if embryo is mutant at only one of the Pc group genes.

(Moazed and O'Farrell, 1992)

Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Scm, Pcl, Sce, Asx, Psc, pho and Antp) cause abnormal segmental development due to the ectopic expression of abd-A and Abd-B.

(Simon et al., 1992)

Aberrant Psc gene expression results in abnormal bristle development.

(Brunk et al., 1991)

The Pc group genes are negative regulators of homeotic genes and have pleiotropic effects on development.

(McKeon and Brock, 1991)

Identification: Isolated from a genomic library using a mouse bmi-1 cDNA as a probe.

(van Lohuizen et al., 1991)

Involved in the suppression of the z¹ eye colour and associated with homeotic transformations.

(Wu et al., 1989)

Dominantly suppresses the yellow eye colour of z¹ flies.

(Wu et al., 1989)

The triple mutant Psc¹ Asx¹ Pcl¹ has a tandem array of posterior abdominal segments including four abdominal denticle bands in the head region.

(Jurgens, 1985)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 75 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36431

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P35820

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

D0Z760

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0005624

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Psc_1
Psc_2

Flygut - An atlas of the Drosophila adult midgut

FBgn0005624

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36431

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034738

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3886

modMine - A data warehouse for the modENCODE project

FBgn0005624

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

10688-Psc[k07834]

BioGRID - A database of protein and genetic interactions.

62201

DroID - A comprehensive database of gene and protein interactions.

FBgn0005624

DRSC - Results frm RNAi screens

FBgn0005624

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0005624

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3886-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0005624

FlyMine - An integrated database for Drosophila genomics

FBgn0005624

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36431

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

49Ea

(Lasko and Pardue, 1988)

CG3886

(Ni et al., 2011.7.19, Ying et al., 2011, Ni et al., 2010.12.1, Berger et al., 2008, Ni et al., 2008, Klebes et al., 2005, Fulton et al., 2001)

D-Bmi

Psc

(DeLuca et al., 2020, Geigges et al., 2020, Harris et al., 2020, Loubiere et al., 2020, Overton et al., 2020, Berlandi et al., 2019, Chai et al., 2019, Cheutin and Cavalli, 2019, Hall et al., 2019, Leatham-Jensen et al., 2019, Luhur et al., 2019, Tudrej et al., 2019, Yang et al., 2019, La Fortezza et al., 2018, Levis, 2018.8.30, Ma et al., 2018, Nishioka et al., 2018, Rennie et al., 2018, Sadasivam and Huang, 2018, Erceg et al., 2017, Huang et al., 2017, Kang et al., 2017, Maini et al., 2017, Monribot-Villanueva et al., 2017, Schwartz and Cavalli, 2017, Transgenic RNAi Project members, 2017-, Bielmeier et al., 2016, Du et al., 2016, Frey et al., 2016, Kahn et al., 2016, Morimoto et al., 2016, Peng et al., 2016, Piunti and Shilatifard, 2016, Shih et al., 2016, Bivik et al., 2015, Dequéant et al., 2015, Dietz et al., 2015, Finley et al., 2015, Ghasemi et al., 2015, Kang et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Comoglio and Paro, 2014, Gambetta and Müller, 2014, Herz et al., 2014, McElroy et al., 2014, Aloia et al., 2013, Bengani et al., 2013, Collins and Moon, 2013, Debruhl et al., 2013, Di Croce and Helin, 2013, Lim et al., 2013, Sen et al., 2013, Vasanthi et al., 2013, Beh et al., 2012, Feller et al., 2012, Follmer et al., 2012, Gutiérrez et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ji et al., 2012, McEachern, 2012, Morillo Prado et al., 2012, Park et al., 2012, Sakoparnig et al., 2012, Stern et al., 2012, Cavalli, 2011, Di Stefano et al., 2011, Du et al., 2011, Enderle et al., 2011, Grau et al., 2011, Klusza and Deng, 2011, Singer and Gall, 2011, Strübbe et al., 2011, Bell et al., 2010, Brown and Kassis, 2010, Gandille et al., 2010, Gan et al., 2010, Grau et al., 2010, Li et al., 2010, Schwartz et al., 2010, Classen et al., 2009, Emmons et al., 2009, Fang et al., 2009, Khan et al., 2009, Sing et al., 2009, Southall and Brand, 2009, Berger et al., 2008, Diop et al., 2008, Doheny et al., 2008, Kim et al., 2008, Matyunina et al., 2008, Oktaba et al., 2008, Pérez-Lluch et al., 2008, Zhang et al., 2008, Bai et al., 2007, Beisel et al., 2007, Bello et al., 2007, Buszczak et al., 2007, de Ayala Alonso et al., 2007, Goodliffe et al., 2007, Mishra et al., 2007, Schuettengruber et al., 2007, Secombe et al., 2007, Holmes et al., 2006, Kavi et al., 2006, Muller and Kassis, 2006, Papp and Muller, 2006, Qi et al., 2006, Schwartz et al., 2006, Brown et al., 2005, King et al., 2005, Ali and Bender, 2004, Breiling et al., 2004, Wang and Brock, 2003, Balasov, 2002, Huang et al., 2002, King et al., 2002, Fitzgerald and Bender, 2001, Hirose et al., 2001)

Psc1

(Erhardt et al., 2003)

Su(z)2-C

(Wu et al., 1989)

Suz2

(Cheutin and Cavalli, 2019)

dPSC

(Lavigne et al., 2004)

l(2)49Ea

(Pauli et al., 1995, Wu et al., 1989)

l(2)Psc

(Cripps and Sparrow, 1989)

l(2)vr14

psc

(Potter et al., 2010, Krupp et al., 2005, Jacobs, 1993)

vr14

(Wu et al., 1989)

Name Synonyms

Posterior Sex Combs

(Wani et al., 2016, Follmer et al., 2012, Lo et al., 2012, McEachern, 2012, Grau et al., 2011, Braunschweig et al., 2009, Lo et al., 2009, Zhang et al., 2008, de la Roche and Bienz, 2007, Mishra et al., 2007, Huang et al., 2002)

Posterior sex comb

(Stern et al., 2012, Suganuma and Workman, 2010, Maeda and Karch, 2006, Balasov, 2002)

posterior sex comb

(Fanti et al., 2008)

posterior sex combs

(Dorn and Dorn, 2015, Deal et al., 2010, Potter et al., 2010)

posterior-sex-combs

(Weber et al., 2010)

Secondary FlyBase IDs

FBgn0002071
FBgn0003153
FBgn0003644

Datasets (2)

Study focus (2)

Experimental Role

Project

Project Type

Title

bait_protein

modENCODE_chromatin_proteins_cells

genome binding

Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_chromatin_proteins_flies

genome binding

Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.

References (410)

The following external sites may use different assemblies or annotations than FlyBase.

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