Posterior sex comb, l(2)49Ea
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Gene model reviewed during 5.55
Gene model reviewed during 5.49
Gene model reviewed during 5.56
6.0 (longest cDNA)
6.6 (northern blot)
1603 (aa)
Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1-55. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
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Comment: reference states 24 hr APF
The Psc protein localizes to the nucleus.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Psc in GBrowse 22-67
2-71.3
2-67.5
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal, polyclonal
A member of the Su(z)2 complex.
Psc on its own is able to inhibit chromatin remodelling in vitro.
Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.
The alleles of Psc define two overlapping phenotypic classes, the 'hopeful' and the 'hapless' alleles.
Members of the Pc group function as potent repressors in mammalian cells.
Psc is not essential for normal bristle differentiation.
Mutations in Psc generate malformations of the longitudinal tracts.
Molecular analysis revealed similarity to the murine oncogene bmi-1.
Maternal rescue explains the lack of a segmental transformation mutant phenotype in embryos.
The bithorax complex genes are regulated by the Pc group of genes, acting via 'Pc group response elements' (PREs), that can work even when removed from the normal the bithorax complex context. The Pc group products apparently provide stable memory or imprinting of boundaries which are specified by gap and pair-rule regulators.
A member of the Polycomb group of genes. May be considered a negative regulator of the BXC or the ANTC.
The mutant is homo- and hemizygous lethal, the embryos showing partial transformation of head and thorax into abdomen and of abdominal segments 1-7 into more posterior ones. Psc1/Psc1 embryos that are also homozygous for Asx1, Pcl1, or Scm1 show stronger posteriorly-directed transformations; Psc1/+ males may have sex combs on second and third legs. Viability reduced in transheterozygotes in some Psc1/Su(z)2 combinations, lethal in others.
Aberrant Psc gene expression results in abnormal bristle development.
The Pc group genes are negative regulators of homeotic genes and have pleiotropic effects on development.
Identification: Isolated from a genomic library using a mouse bmi-1 cDNA as a probe.
Involved in the suppression of the z1 eye colour and associated with homeotic transformations.
Dominantly suppresses the yellow eye colour of z1 flies.