Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
182 (aa); 20 (kD)
Several forms of flightin are thought to be produced through post-translational modifications, possibly by phosphorylation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fln using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fln in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
fln is required for the establishment of normal thick filament length in the indirect flight muscle during late pupal development and for thick filament stability in the adult after initiation of contractile activity.
Flightin exists in 11 isoelectric variants, of both phosphorlated and non-phosphorylated classes. There is a dramatic increase in flightin phosphorylation on adult eclosion.
fln is a structural component of the thick filaments whose regulated phosphorylation is dependent upon the presence of fully assembled thin filaments or the activity of thin filament protein.
Flightin is a protein of the A band of the sarcomere of the indirect flight muscles. Exists in various, probably post-translationally modified, isoforms (kD 27-30; pI 4.6-6.0). Isoform pattern changes after emergence. Probably interacts with myosin, as the 12 N-terminal amino acids are similar to those of actin, which also interacts with myosin.