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FB2026_02
,
released June 18, 2026
mp27
Please see the JBrowse view of Dmel\fln for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
1.0 (northern blot)
182 (aa); 20 (kD)
Several forms of flightin are thought to be produced through post-translational modifications, possibly by phosphorylation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fln using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
fln transcripts are detected in late pupae and adults. They localize exclusively to indirect flight muscles in adult flies.
fln protein localizes exclusively to the indirect flight muscles.
JBrowse - Visual display of RNA-Seq signals
View Dmel\fln in JBrowse3-46
3-43.5
Maps 23.1 map units from e.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
fln is required for the establishment of normal thick filament length in the indirect flight muscle during late pupal development and for thick filament stability in the adult after initiation of contractile activity.
Flightin exists in 11 isoelectric variants, of both phosphorlated and non-phosphorylated classes. There is a dramatic increase in flightin phosphorylation on adult eclosion.
fln is a structural component of the thick filaments whose regulated phosphorylation is dependent upon the presence of fully assembled thin filaments or the activity of thin filament protein.
Flightin is a protein of the A band of the sarcomere of the indirect flight muscles. Exists in various, probably post-translationally modified, isoforms (kD 27-30; pI 4.6-6.0). Isoform pattern changes after emergence. Probably interacts with myosin, as the 12 N-terminal amino acids are similar to those of actin, which also interacts with myosin.
