l(2)35Ba, l(2)br22, nocA, br22, BG:DS04641.1
Please see the JBrowse view of Dmel\noc for information on other features
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Gene model reviewed during 5.51
~3 (northern blot)
537 (aa)
Interacts with elB.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\noc using the Feature Mapper tool.
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as posterior spiracle specific anlage
noc is first expressed in the blastoderm embryo in the procephalic ectoderm and in one anterior stripe. After this, seven stripes emerge with expression strongest in stripe 2 and in the ventral region of the stripes. Expression in stripe 8 and stripes 3-7 becomes stronger as development proceeds. Later in germ band extension, as segment polarity pattern emerges with doubled stripes.
noc transcripts are detected in all stages on northern blots with maximal levels occuring in embryonic and pupal stages as well as in adult heads. The two transcripts are present in nearly equal amounts and appear to be coordinately regulated. Transcripts are first detected by in situ hybridization in cellular blastoderm embryos in a rapidly evolving pattern. The initial hybridization at 95-100% egg length retracts to a stripe at 90-95% egg length. This is followed by an additional 2 stripes just posterior to the initial stripe and a stripe near the posterior terminus. 6 more stripes appear along the trunk giving a total of 10. During gastrulation, the 2nd and 3rd anterior-most stripes border the cephalic furrow. Striped expression disappears after gastrulation. By stage 8, expression is seen in the procephalic lobe and along the ventral ectoderm from 50-90% egg length, spanning the cephalic furrow. 12 stripes of expression are seen in the neuroectoderm in stage 9. In stages 10-12, ectodermal expression abd expression around tracheal placodes decreases. Cephlaic expression occurs as two groups of dorsal ectodermal cells in the procephalic lobe as well as the labral segment and stomodeum. After stage 13, no clear pattern is seen and expression is thought to be ubiquitous.
In second instar eye-antenna discs, elB and noc expression is restricted to the eye primordium. In early third instar discs, expression in the distal part of the antenna primordium is observed. In the eye-head primordium, elB and noc are expressed in the hth domain that indicates the proliferative region. In late third instar larval discs, expression levels remain high in the region anterior to the morphogenetic furrow, at more elevated levels in cells that co-express hth and tsh and at lower levels in the pre-proneural region. Thus elB and noc are expressed at higher levels in the proliferative region of the eye-head primordium.
GBrowse - Visual display of RNA-Seq signals
View Dmel\noc in GBrowse 22-50
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: noc CG4491
The "Sco" (Scutoid) mutant allele was previously listed as an allele of noc in FlyBase, as genetic analysis showed that a high dose of the wild-type noc gene suppresses the expressivity of the Sco phenotype, suggesting that Sco was an antimorphic allele of noc (FBrf0038047). However, FBrf0111871 shows that Sco is in fact an antimorphic allele of sna, and the mutant phenotype is caused by ectopic expression of sna in the eye-antennal and wing imaginal discs. The Sco allele is therefore now listed as an allele of sna in FlyBase. FBrf0111871 suggests that the reason that noc in trans affects the expressivity of Sco may be due to transvection effects, as they show that mutations in z, a mediator of transvection, also affect the Sco mutant phenotype.
The noc and elB paralogs interact with hth to correctly specify the photoreceptors which detect polarised light at the dorsal rim of the retina, being involved in specifying both morphological and molecular fate. noc and elB also antagonise the transcriptional activator and repressor functions of oc in the retina through distinct protein domains.
Ashburner.