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FB2021_04, released August 17, 2021

Gene: Dmel\noc

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General Information
Symbol
Dmel\noc
Species
D. melanogaster
Name
no ocelli
Annotation Symbol
CG4491
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005771
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development. (UniProt, Q24423)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(2)35Ba, l(2)br22, nocA, br22, BG:DS04641.1

Key Links
Genomic Location
Cytogenetic map
35B2-35B2
Sequence location
2L:14,490,859..14,494,019 [+]
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14490859..14494019
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:elB; FB:FBgn0004858
(Dorfman et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in brain development
inferred from mutant phenotype
(assigned by UniProt )
(Cheah et al., 1994)
involved_in compound eye photoreceptor fate commitment
inferred from genetic interaction with FLYBASE:elB; FB:FBgn0004858
(Wernet et al., 2014)
involved_in eye-antennal disc development
inferred from genetic interaction with FLYBASE:elB; FB:FBgn0004858
(Luque and Milan, 2007)
involved_in leg disc development
inferred from mutant phenotype
(assigned by UniProt )
(Weihe et al., 2004)
involved_in ocellus development
inferred from mutant phenotype
(assigned by UniProt )
(Cheah et al., 1994)
involved_in open tracheal system development
inferred from mutant phenotype
(Dorfman et al., 2002)
involved_in wing disc development
inferred from mutant phenotype
(assigned by UniProt )
(Weihe et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of transcription, DNA-templated
inferred from biological aspect of ancestor with PANTHER:PTN000968869
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000968869
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Elbow/Noc family. (Q24423)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development.
(UniProt, Q24423)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(2)35Ba
l(2)35Ba1 may escape in combination with deficiency for the locus; escapers are weak elbow in phenotype if deficiency includes el, but not if it does not. All alleles express weak elbow in combination with el1; heteroallelic escapers [i.e., l(2)35Ba4 in combination with other alleles] are weak elbow. Semilethal with In(2LR)Scorv1 and Scorv27; also show weak noc phenotype in combination with strong noc alleles.
noc: no ocelli
The genetic complexity of noc is indicated by phenotypic as well as molecular data (McGill et al., 1988). Mutants are characterized by partial or complete absence of ocelli and their associated bristles. Strong noc alleles lack all three ocelli and have fewer interocellar microchaetae; ocellar and interocellar bristles are absent; anterior postalar and notopleural bristles may not be present; postvertical bristles are crooked, an adventitious pair often occurring between a normal pair. Weak alleles may overlap wild type in phenotype, the flies having smaller ocelli and an aberrant pattern of interocellar microchaetae. Male and female homozygotes are viable and fertile. Penetrance and expressivity is stronger in males and in flies that emerge later. While a homozygous deletion of the entire noc region is lethal, distal or proximal regions can be homozygously deleted without causing lethality. Some noc alleles and deficiences are lethal with In(2L)Scorv1, whose 2L breakpoint lies within noc, while other alleles are viable with the Sco inversion.
Sco: Scutoid
Sco/+ flies exhibit the loss of 10-15 bristles, scutellars, notopleurals, upper humerals and anterior postalars being most frequently affected; removes both trichogen and tormogen cell derivatives. Homozygotes nearly lethal; rare homozygous or hemizygous escapers have only eight or so bristles per fly; eyes small and very rough. Escapers short lived and sterile. RK1A.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\noc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
noc-RA
FBtr0080643
NM_057569
2859
537
noc-RB
FBtr0342913
NM_001299003
2673
537
Additional Transcript Data and Comments
Reported size (kB)

~3 (northern blot)

(Cheah et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
noc-PA
FBpp0080215
54.0
537
9.13
NP_476917
AAF53399
noc-PB
FBpp0309705
54.0
537
9.13
NP_001285932
AHN54446
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

537 aa isoforms: noc-PA, noc-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

537 (aa)

(Cheah et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with elB.

(UniProt, Q24423)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\noc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
organism | anterior | terminal expression pattern
(Dorfman et al., 2002)
organism | posterior | terminal expression pattern
(Dorfman et al., 2002)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
organism | 90-100% egg length

Comment: 90-95% egg length

(Cheah et al., 1994)
organism | pair rule expression pattern
(Hou et al., 2009)
embryonic stage 5 -- 6
ectoderm | striped
(Dorfman et al., 2002, Cheah et al., 1994)
embryonic stage 5 -- 9
procephalic segment
(Hou et al., 2009)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 8
ventral nerve cord primordium | 50-90% egg length
(Cheah et al., 1994)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 10
organism | segment polarity expression pattern
(Hou et al., 2009)
embryonic stage 10 -- 11
embryonic/larval trachea
(Chung et al., 2011)
embryonic stage 10 -- 12
tracheal primordium | surrounding
(Cheah et al., 1994)
embryonic stage 11
tracheal pit
(Dorfman et al., 2002)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
labial sensory complex primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
posterior spiracle primordium

Comment: reported as posterior spiracle specific anlage

(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
embryonic stage 13 -- 17
organism | ubiquitous
(Dorfman et al., 2002)
third instar larval stage
presumptive ocellus
(Birkholz et al., 2009)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Cheah et al., 1994)
embryonic stage 8 -- 12
labral segment
(Cheah et al., 1994)
stomodeum
(Cheah et al., 1994)
procephalic segment
(Cheah et al., 1994)
embryonic stage 9
ventral neurectoderm | striped
(Cheah et al., 1994)
Additional Descriptive Data

noc is first expressed in the blastoderm embryo in the procephalic ectoderm and in one anterior stripe. After this, seven stripes emerge with expression strongest in stripe 2 and in the ventral region of the stripes. Expression in stripe 8 and stripes 3-7 becomes stronger as development proceeds. Later in germ band extension, as segment polarity pattern emerges with doubled stripes.

(Hou et al., 2009)

noc transcripts are detected in all stages on northern blots with maximal levels occuring in embryonic and pupal stages as well as in adult heads. The two transcripts are present in nearly equal amounts and appear to be coordinately regulated. Transcripts are first detected by in situ hybridization in cellular blastoderm embryos in a rapidly evolving pattern. The initial hybridization at 95-100% egg length retracts to a stripe at 90-95% egg length. This is followed by an additional 2 stripes just posterior to the initial stripe and a stripe near the posterior terminus. 6 more stripes appear along the trunk giving a total of 10. During gastrulation, the 2nd and 3rd anterior-most stripes border the cephalic furrow. Striped expression disappears after gastrulation. By stage 8, expression is seen in the procephalic lobe and along the ventral ectoderm from 50-90% egg length, spanning the cephalic furrow. 12 stripes of expression are seen in the neuroectoderm in stage 9. In stages 10-12, ectodermal expression abd expression around tracheal placodes decreases. Cephlaic expression occurs as two groups of dorsal ectodermal cells in the procephalic lobe as well as the labral segment and stomodeum. After stage 13, no clear pattern is seen and expression is thought to be ubiquitous.

(Cheah et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
second instar larval stage
eye-antennal disc | restricted
(Luque and Milan, 2007)
third instar larval stage
eye-antennal disc | restricted
(Luque and Milan, 2007)
late third instar larval stage
eye disc anterior to the morphogenetic furrow
(Luque and Milan, 2007)
Additional Descriptive Data

In second instar eye-antenna discs, elB and noc expression is restricted to the eye primordium. In early third instar discs, expression in the distal part of the antenna primordium is observed. In the eye-head primordium, elB and noc are expressed in the hth domain that indicates the proliferative region. In late third instar larval discs, expression levels remain high in the region anterior to the morphogenetic furrow, at more elevated levels in cells that co-express hth and tsh and at lower levels in the pre-proneural region. Thus elB and noc are expressed at higher levels in the proliferative region of the eye-head primordium.

(Luque and Milan, 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\noc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of noc
Transgenic constructs containing regulatory region of noc
Aberrations (Deficiencies and Duplications) ( 311 )
Inferred from experimentation ( 311 )
Gene disrupted in
Df(2L)64j
(Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)A47
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)
Df(2L)A178
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(McNabb et al., 1996, Roote et al., 1996, Cheah et al., 1994, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(McNabb et al., 1996, Roote et al., 1996, Davis et al., 1990, Ashburner et al., 1982)
Df(2L)A263
(Ashburner et al., 1982)
Df(2L)A266
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A267
(Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A377
(Ashburner et al., 1982)
Df(2L)A379
(McNabb et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A400
(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(McNabb et al., 1996, Ashburner et al., 1982)
Df(2L)Adh-nBR41
(Fossett et al., 1990)
Df(2L)Adh-nBR55
(Fossett et al., 1990)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Roote, 1996.1.11, Roote, 1996.8)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR119
(Roote, 1996.1.11)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Roote, 1996.1.11)
Df(2L)Adh-nBR129
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996, Davis et al., 1990)
Df(2L)b81a1
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b84a1
(McNabb et al., 1996)
Df(2L)b84a4
(Roote, 2000.7.3, McNabb et al., 1996, Roote et al., 1996)
Df(2L)b84a5
(Roote et al., 1996)
Df(2L)b84a8
(Roote, 2000.7.3, McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996)
Df(2L)b88c25
(Alexandrova et al., 1996)
Df(2L)BSC862
(Cook and Cook, 2010.2.17)
Df(2L)do1
(Ashburner et al., 1981)
Df(2L)ED3
(Ryder and Roote, 2004.11.10, Ryder et al., 2004, Roote, 2002.2.6)
Df(2L)el14
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
Df(2L)el16
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
Df(2L)el28
(Davis et al., 1997, Davis et al., 1990)
Df(2L)el77
(McNabb et al., 1996, Woodruff and Ashburner, 1979)
Df(2L)el80f1
(Ashburner et al., 1983)
Df(2L)Exel8033
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn2
(Davis et al., 1997, McNabb et al., 1996, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn3
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Davis et al., 1990, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn5
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn7
(McNabb et al., 1996, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn12
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn15
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn26
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn27
(Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn30
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn31
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn36
(McNabb et al., 1996, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn52
(McNabb et al., 1996)
Df(2L)GT4
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1990)
Df(2L)GT5
(Roote, 1996.1.11, Roote, 1996.8, Gubb et al., 1990)
Df(2L)n78l3
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Ashburner et al., 1982)
Df(2L)nNxF1
(Chia et al., 1985)
Df(2L)nNxF2
(Chia et al., 1985)
Df(2L)noc10
(McNabb et al., 1996)
Df(2L)noc13
(McNabb et al., 1996)
Df(2L)noc20
(McNabb et al., 1996)
Df(2L)osp144
(McNabb et al., 1996, Roote, 1996.8, Ashburner et al., 1982)
Df(2L)osp-204
Df(2L)PA4
(Ashburner et al., 1983)
Df(2L)Sco7
(Ashburner et al., 1983)
Df(2L)Scorv4
(Ashburner et al., 1990, Ashburner et al., 1983)
Df(2L)Scorv10
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv14
(Ashraf et al., 1999, Ashburner et al., 1983)
Df(2L)Scorv16
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv18
(Ashraf et al., 1999, Ashburner et al., 1983)
Df(2L)Scorv19
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv23
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv25
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)TE35B-1
(Davis et al., 1997, Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Davis et al., 1997, Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-7
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-8
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(McNabb et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-10
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-11
(McNabb et al., 1996, Roote et al., 1996)
Df(2L)TE35B-12
(Davis et al., 1997, Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-15
(McNabb et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-48
(McNabb et al., 1996, Roote et al., 1996)
Df(2L)TE35B-50
(Roote et al., 1996)
Df(2L)TE35B-54L
(Gubb et al., 1997, Roote, 1996.8, Roote et al., 1996)
Df(2L)TE35B-54
(McNabb et al., 1996, Roote et al., 1996)
Df(2L)TE35B-203
(Roote et al., 1996)
Df(2L)TE35B-300
(Roote et al., 1996)
Df(2L)TE35B-400
(Roote et al., 1996, Roote, 1995.3.27)
Df(2L)TE35B-401
(Roote et al., 1996, Roote, 1995.3.27)
Df(2L)TE35B-402
(Roote et al., 1996, Roote, 1995.3.27)
Df(2L)TE35B-403
(Roote et al., 1996, Roote, 1995.3.27)
Df(2L)TE35B-407
(Roote et al., 1996, Roote, 1995.3.27)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Davis et al., 1997, Davis et al., 1990, Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)TE35D-24
(Roote et al., 1996)
Df(2L)W
(McNabb et al., 1996, Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Dp(2;2)Cam12
(Gubb et al., 1997, Roote et al., 1996, Roote, 1995.3.27)
In(2)TE35B-1a
(Roote et al., 1996)
In(2)TE35B-101
(Roote et al., 1996)
In(2)TE35B-219
(Roote et al., 1996)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979)
In(2L)75c
(Grau et al., 1984, Woodruff and Ashburner, 1979)
In(2L)C158LScorv11R
(Ashburner et al., 1983)
In(2L)C158LScorv17R
(Ashburner et al., 1983)
In(2L)noc2
(Davis et al., 1997)
In(2L)TE35B-1
(Roote et al., 1996)
In(2L)TE35B-8
(Roote et al., 1996)
In(2L)TE35B-9
(Roote et al., 1996)
In(2L)TE35B-11
(Roote et al., 1996)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2L)TE35B-16
(Roote et al., 1996)
In(2L)TE35B-27
(Roote et al., 1996)
In(2L)TE35B-55
(Roote et al., 1996)
In(2L)TE35B-56
(Roote et al., 1996)
In(2L)TE35B-63
(Roote et al., 1996)
In(2L)TE35B-210LC163.41R
(Roote, 2004.3.1, Gubb et al., 1997, Roote et al., 1996)
In(2L)TE35B-210
(Roote et al., 1996)
In(2L)TE35B-220
(Roote et al., 1996)
In(2L)TE35B-225
(Roote et al., 1996)
In(2L)TE35B-227
(Roote et al., 1996)
In(2L)TE35B-400
(Roote et al., 1996)
In(2LR)b81a2LDTD43R
(Roote, 2000.7.3, Roote et al., 1996, Roote, 1995.3.27)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
In(2LR)el6LA379R
(Roote et al., 1996)
In(2LR)noc4
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994)
In(2LR)noc4LD6R
(Roote et al., 1996)
In(2LR)noc4LScorv9R
(Ashraf et al., 1999, Roote et al., 1996, Ashburner and Harrington, 1984)
In(2LR)noc4LTE35B-50R
(Roote, 1995.3.27)
In(2LR)noc7
(Davis et al., 1997)
In(2LR)pkD1-rv1
(Roote, 1997.6.6)
In(2LR)pkD1-rv4
(Roote, 1997.6.6)
In(2LR)pkD1-rv5
(Roote, 1997.6.6)
In(2LR)pkD1-rv6
(Roote, 1997.6.6)
In(2LR)pkD1-rv7
(Roote, 1997.6.6)
In(2LR)pkD1-rv9
(Roote, 1997.6.6)
In(2LR)pkD1-rv2
(Roote, 1997.6.6)
In(2LR)pkD1-rv3
(Roote, 1997.6.6)
In(2LR)pkD1-rv8
(Roote, 1997.6.6)
In(2LR)pkD1-rv10
(Roote, 1997.6.6)
In(2LR)TE35B-4LTE35B-250R
(Roote, 1997.6.6)
In(2LR)TE35B-4
(Roote et al., 1996)
In(2LR)TE35B-6LScorv9R
(Roote et al., 1996, Ashburner and Harrington, 1984)
In(2LR)TE35B-6
(Roote et al., 1996)
In(2LR)TE35B-14LScorv1R
(Roote, 1996.8, Roote et al., 1996)
In(2LR)TE35B-14
(Roote et al., 1996)
In(2LR)TE35B-15LScorv1R
(Gubb et al., 1997, Roote et al., 1996)
In(2LR)TE35B-15
(Roote et al., 1996)
In(2LR)TE35B-50
(Roote et al., 1996)
In(2LR)TE35B-205
(Roote et al., 1996)
In(2LR)TE35B-222
(Roote et al., 1996)
In(2LR)TE35B-223
(Roote et al., 1996)
In(2LR)TE35B-226
(Roote et al., 1996)
T(1;2;3)TE35B-100
(Roote et al., 1996)
T(1;2)TE35B-217
(Roote et al., 1996)
T(2;3)GT7
(Gubb et al., 1990)
T(2;3)GT8
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Davis et al., 1990, Gubb et al., 1990)
T(2;3)Scorv7
(Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983)
T(2;3)TE35B-2a
(Chia et al., 1985)
T(2;3)TE35B-2
(Roote et al., 1996)
T(2;3)TE35B-3DG16P
(Roote, 1995.3.27, Chia et al., 1985)
T(2;3)TE35B-3a
(Roote et al., 1996)
T(2;3)TE35B-3
(Roote et al., 1996)
T(2;3)TE35B-4
(Roote et al., 1996)
T(2;3)TE35B-5
(Roote et al., 1996)
T(2;3)TE35B-7
(Roote et al., 1996)
T(2;3)TE35B-25
(Roote et al., 1996)
T(2;3)TE35B-26
(Roote et al., 1996)
T(2;3)TE35B-28
(Roote et al., 1996)
T(2;3)TE35B-58
(Roote et al., 1996)
T(2;3)TE35B-200
(Roote et al., 1996)
T(2;3)TE35B-202
(Roote et al., 1996)
T(2;3)TE35B-207
(Roote et al., 1996)
T(2;3)TE35B-208
(Roote et al., 1996)
T(2;3)TE35B-209
(Roote et al., 1996)
T(2;3)TE35B-212
(Roote et al., 1996)
T(2;3)TE35B-215
(Roote et al., 1996)
T(2;3)TE35B-216
(Roote et al., 1996)
T(2;3)TE35B-218
(Roote et al., 1996)
T(2;3)TE35B-221
(Roote et al., 1996)
T(2;3)TE35B-224
(Roote et al., 1996)
T(2;3)TE35B-229
(Roote et al., 1996)
T(2;3)TE35B-230
(Roote et al., 1996)
T(2;3)TE35B-401
(Roote et al., 1996)
T(2;4)TE35B-50
(Roote, 1996.8, Roote et al., 1996)
T(2;4)TE35B-101
(Roote et al., 1996)
T(2;4)TE35B-214
(Roote et al., 1996)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
T(Y;2)GT1
(Gubb et al., 1990)
T(Y;2)TE35B-51
(Roote et al., 1996)
T(Y;2)TE35B-102
(Roote et al., 1996)
T(Y;2)TE35B-201
(Roote et al., 1996)
T(Y;2)TE35B-204
(Roote et al., 1996)
T(Y;2)TE35B-206
(Roote et al., 1996)
T(Y;2)TE35B-211
(Roote et al., 1996)
T(Y;2)TE35B-213
(Roote et al., 1996)
Tp(1;2)TE35B-SZ5
Tp(1;2)TE35B
(Davis et al., 1997, Lovering et al., 1991, Harden and Ashburner, 1990, Gubb et al., 1986, Gubb et al., 1985, Ashburner et al., 1981)
Tp(2;2)A446
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Tp(2;2)TE35B-54
(Roote et al., 1996)
Tp(2;3)TE35B-203
(Roote et al., 1996)
Ts(2Lt;3Lt)H147+Ts(2Rt;3Rt)TE35B-8
(Roote et al., 1996)
Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16
(Chia et al., 1985)
Ts(2Lt;3Lt)TE35B-3+Ts(2Rt;3Rt)G16
(Gubb et al., 1997, Roote et al., 1996)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Roote et al., 1996, Chia et al., 1985, Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Gubb et al., 1997, Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)pb-3a
(Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Ashburner et al., 1983)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;4Lt)GT6+Ts(2Rt;4Rt)TE35B-101
(Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;4Lt)TE35B-50+Ts(2Rt;4Rt)DTD22
(Gubb et al., 1997, Roote et al., 1996)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Davis et al., 1997, Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1981)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)R15
(Gubb et al., 1997, Roote et al., 1996, Davis et al., 1990)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Gene duplicated in
Dp(2;1)Scorv23
(Ashburner et al., 1983)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Gene not duplicated in
Dp(2;1;f)Scorv23-X2
Dp(2;3)osp3
(Roote et al., 1996)
In(2L)C163.41LC158R
(Roote et al., 1996, Ashburner et al., 1982)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene partially disrupted in
Df(2L)A178
(Fossett et al., 1994)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)A379
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)A445
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR106
(Roote et al., 1996)
Df(2L)Adh-nBR119
(Roote, 1996.8, Roote et al., 1996)
Df(2L)Adh-nBR126
(Roote, 1996.8, Roote et al., 1996)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)ED3
(Ryder et al., 2007)
Df(2L)fn27
(Roote et al., 1996)
Df(2L)nNxF1
(Roote, 1996.8, Roote et al., 1996)
Df(2L)nNxF2
(Roote et al., 1996)
Df(2L)osp144
(Roote et al., 1996)
Df(2L)PA4
(Roote et al., 1996)
Df(2L)Scorv4
(Roote et al., 1996)
Df(2L)Scorv10
(Roote et al., 1996)
Df(2L)Scorv14
(Roote et al., 1996)
Df(2L)Scorv18
(Roote et al., 1996)
Df(2L)Scorv25
(Roote et al., 1996)
Df(2L)TE35B-11
(Gubb et al., 1985)
Df(2L)TE35BC-7
(Roote et al., 1996)
Df(2L)TE35D-20
(Roote et al., 1996)
In(2L)noc2
(Roote et al., 1996)
In(2L)Scorv8
(Roote et al., 1996)
In(2L)Scorv24
(Roote et al., 1996)
In(2LR)noc7
(Roote et al., 1996)
In(2LR)pkD1-rv11
(Roote, 1997.6.6)
In(2LR)pkD1-rv12
(Roote, 1997.6.6)
In(2LR)Scorv1
(Roote et al., 1996)
In(2LR)Scorv9
(Roote et al., 1996)
T(2;3)Scorv7
(Roote et al., 1996)
Tp(1;2)TE35B-GR17
Tp(2;2)A446
(Fossett et al., 1994)
Tp(2;2)Scorv12
(Roote et al., 1996)
Tp(2;2)Sco
(Roote et al., 1996)
Tp(3;2)osp204
(Roote et al., 1996)
Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16
(Roote et al., 1996)
Gene not disrupted in
Df(2L)A48
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A63
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A220
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR105
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR111
(Fossett et al., 1990)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR122
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR128
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)b75
(Gubb et al., 1990, Woodruff and Ashburner, 1979)
Df(2L)b80e3
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b83d29a
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
Df(2L)b84a2
(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Davis et al., 1990)
Df(2L)b88h49
(Roote et al., 1996)
Df(2L)el94
(Roote, 1996.1.11, Roote, 1996.8)
Df(2L)fn3
(Woodruff and Ashburner, 1979)
Df(2L)fn27
(Davis et al., 1997)
Df(2L)fn52
(Roote, 1996.8)
Df(2L)osp18
(McNabb et al., 1996)
Df(2L)osp29
(McNabb et al., 1996, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982)
Df(2L)osp201
(McNabb et al., 1996)
Df(2L)SS1
(Grau et al., 1984)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Grau et al., 1984, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-4
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(McNabb et al., 1996, Gubb et al., 1984)
Df(2L)TE35BC-34
(Gubb et al., 1984)
Df(2L)TE35BC-35
(McNabb et al., 1996, Gubb et al., 1984)
In(2L)C158LScorv11R
(Ashburner and Harrington, 1984)
In(2L)C158LScorv17R
(Ashburner and Harrington, 1984)
In(2L)C158
(McNabb et al., 1996)
In(2L)el9
(Davis et al., 1990)
In(2L)osp22
(McNabb et al., 1996)
In(2L)osp59
(McNabb et al., 1996)
In(2L)Scorv11
(Roote et al., 1996)
In(2L)Scorv17
(Roote et al., 1996)
In(2LR)DTD128
(Davis et al., 1990)
In(2LR)el6
(Davis et al., 1990)
T(2;3)dpps19
(Davis et al., 1990)
T(2;3)el24
(Roote et al., 1996, Davis et al., 1990)
T(2;3)GT7
(Roote et al., 1996)
T(2;3)GT10
(Davis et al., 1990)
T(2;3)H47
(McNabb et al., 1996)
T(2;3)Mpe
(Davis et al., 1997, McNabb et al., 1996)
T(2;3)osp90
(McNabb et al., 1996)
T(2;3)TE35B-2a
(Chia et al., 1985)
T(2;3)TE35BC-3
(McNabb et al., 1996)
T(Y;2)a15
(Davis et al., 1990)
T(Y;2)A80
(Davis et al., 1990)
T(Y;2)el4
(Davis et al., 1990)
T(Y;2)GT1
(Davis et al., 1997, Roote et al., 1996)
T(Y;2)GT2
(Davis et al., 1990)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979)
T(Y;2)TE35B-18
(Roote et al., 1996)
Tp(2;3)GT3
(Davis et al., 1990)
Tp(2;3)osp3
(McNabb et al., 1996)
Tp(2;3)pb3
(McNabb et al., 1996)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16
(Chia et al., 1985)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(McNabb et al., 1996, Ashburner and Harrington, 1984)
Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80
(Davis et al., 1997)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Davis et al., 1997, Roote et al., 1996)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ZNF503
13 of 15
Yes
Yes
1  
Hsap\ZNF703
12 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Zfp503
12 of 15
Yes
Yes
Mmus\Zfp703
10 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Zfp503
11 of 13
Yes
Yes
Rnor\Zfp703
10 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\znf503
12 of 12
Yes
Yes
Xtro\znf703
12 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\znf503
13 of 15
Yes
Yes
Drer\znf703
11 of 15
No
Yes
Drer\LOC100333111
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\tlp-1
5 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A5V )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000891
Drosophila simulans
Dsim\GD23964
Drosophila sechellia
Dsec\GM15623
Drosophila erecta
Dere\GG25118
Drosophila yakuba
Dyak\GE19034
Drosophila ananassae
Dana\GF14886
Drosophila pseudoobscura pseudoobscura
Dpse\GA18219
Drosophila persimilis
Dper\GL25989
Drosophila willistoni
Dwil\GK18287
Drosophila virilis
Dvir\GJ18020
Drosophila mojavensis
Dmoj\GI10311
Drosophila grimshawi
Dgri\GH23905
Drosophila grimshawi
Dgri\GH13513
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509OR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018825
Glossina morsitans
Tsetse fly
Gmor\GMOY005303
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07547
Mayetiola destructor
Hessian fly
Mdes\Mdes014506
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015487
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006476
Anopheles darlingi
American malaria mosquito
Adar\ADAC010331
Anopheles gambiae
Malaria mosquito
Agam\AGAP010223
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000826
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AS2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008080
Danaus plexippus
Monarch butterfly
Dple\DPOGS201265-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012144
Apis florea
Little honeybee
Aflo\4272954708
Apis mellifera
Western honey bee
Amel\LOC408265
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19894
Bombus terrestris
Buff-tailed bumblebee
Bter\15202914
Linepithema humile
Argentine ant
Lhum\LH14186
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000749
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005518
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02796
Tribolium castaneum
Red flour beetle
Tcas\noc
Pediculus humanus
Human body louse
Phum\PHUM126330
Rhodnius prolixus
Kissing bug
Rpro\RPRC003027
Cimex lectularius
Bed bug
Clec\CLEC009469
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007893
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13675
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0AP6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007951
Ixodes scapularis
Black-legged tick
Isca\ISCW005133
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59225.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69097.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g06700
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_98257
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_313437
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GV9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Znf503
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023630
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
elB
5 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ZNF503; zinc finger protein 503
    13 of 15
    613902
         
        ZNF703; zinc finger protein 703
        12 of 15
        617045
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            noc - Dr
            two hybrid array
            (Shokri et al., 2019)
            noc - Ubx
            bimolecular fluorescence complementation, fluorescence microscopy
            (Bischof et al., 2018)
            noc - elB
            pull down, autoradiography
            (Dorfman et al., 2002)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            elB|noc
            suppressible
            mam
            (Luque and Milan, 2007)
            elB|noc
            suppressible
            N
            (Luque and Milan, 2007)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            L
            suppressible
            noc
            (Singh et al., 2005)
            sna
            enhanceable
            noc
            (Davis et al., 1997, Gubb et al., 1986)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with elB.
            (UniProt, Q24423 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-50
            Cytogenetic map
            35B2-35B2
            Sequence location
            2L:14,490,859..14,494,019 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            35B2-35B2
            Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            35A4-35A4
            (determined by in situ hybridisation)
            (McGill et al., 1988)
            35B1-35B2
            (determined by in situ hybridisation)
            (Chia et al., 1985)
            Experimentally Determined Recombination Data
            Location

            2-50

            (FlyBase, 2016)

            2-46.8

            (Comeron et al., 2012)

            2-51.0

            (Tomkiel et al., 1995)

            2-

            (Krivshenko, 1959)
            Left of (cM)
            Right of (cM)
            (Tomkiel et al., 1995)
            Notes
            Stocks and Reagents
            Stocks (16)
            Genomic Clones (24)
            cDNA Clones (150)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: noc CG4491

              (Kodira, 1999.11)
              Source for database merge of
              Additional comments

              The "Sco" (Scutoid) mutant allele was previously listed as an allele of noc in FlyBase, as genetic analysis showed that a high dose of the wild-type noc gene suppresses the expressivity of the Sco phenotype, suggesting that Sco was an antimorphic allele of noc (FBrf0038047). However, FBrf0111871 shows that Sco is in fact an antimorphic allele of sna, and the mutant phenotype is caused by ectopic expression of sna in the eye-antennal and wing imaginal discs.  The Sco allele is therefore now listed as an allele of sna in FlyBase.  FBrf0111871 suggests that the reason that noc in trans affects the expressivity of Sco may be due to transvection effects, as they show that mutations in z, a mediator of transvection, also affect the Sco mutant phenotype.

              (FlyBase, 1992-)
              Other Comments

              The noc and elB paralogs interact with hth to correctly specify the photoreceptors which detect polarised light at the dorsal rim of the retina, being involved in specifying both morphological and molecular fate. noc and elB also antagonise the transcriptional activator and repressor functions of oc in the retina through distinct protein domains.

              (Wernet et al., 2014)

              Loss of elB and noc activities induce extensive outgrowths, in a N-dependent way. These overgrowths are not linked to ectopic production of os.

              (Luque and Milan, 2007)

              noc appears, with elB, to regulate the growth of the highly proliferative tissue of the eye-head primordium.

              (Luque and Milan, 2007)
              Origin and Etymology
              Discoverer

              Ashburner.

              Etymology
              Identification
              External Crossreferences and Linkouts ( 44 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB
              EMBL-EBI Single Cell Expression Atlas
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (15)
              Reported As
              Symbol Synonym
              BG:DS04641.1
              (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
              CG4491
              (Meadows, 2018.4.4, Hadar et al., 2012, Page et al., 2012, Weber et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)
              Noc
              (Hsiao et al., 2014, Michaut et al., 2011, Terriente et al., 2008)
              NocA
              (Pereira et al., 2016)
              br22
              (Gubb et al., 1985, Ashburner and Harrington, 1984, Grau et al., 1984)
              el
              (Luque and Milan, 2007)
              l(2)35Ba
              (Davis, 2003.5.6, Ashburner et al., 1999, Gubb et al., 1997, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Dubin et al., 1995, Davis et al., 1990, Fossett et al., 1990, Gubb et al., 1990)
              l(2)35Ba/nocA
              (Cheah et al., 1994)
              l(2)br22
              (Gubb et al., 1986, Gubb et al., 1984, Ashburner et al., 1983, Ashburner et al., 1982)
              l35Ba
              (Fossett et al., 1994)
              noc
              (Michki et al., 2021, Winbush and Singh, 2021, Reis et al., 2020, Dorafshan et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Franz et al., 2017, Tseng and Hsu, 2017, Dubois et al., 2016, Shlyueva et al., 2016, Schertel et al., 2015, Victorsen and White, 2014.5.13, Wernet et al., 2014, Combs and Eisen, 2013, Jin et al., 2013, Gutiérrez et al., 2012, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Weber et al., 2012, Chung et al., 2011, Kazemian et al., 2011, Tom et al., 2011, Cook and Cook, 2010.2.17, Specchia et al., 2010, Birkholz et al., 2009, Hou et al., 2009, Perea et al., 2009, Engström et al., 2007, Ryder et al., 2007, Negre et al., 2006)
              nocA
              (Davis, 2003)
              nocA
              (Ainsley et al., 2003, Glazer et al., 2000, Fossett et al., 1994, Cheah, 1993)
              Name Synonyms
              no ocelli
              (Dubois et al., 2016, Edwards et al., 2009, Hou et al., 2009, Perea et al., 2009, Harbison and Sehgal, 2008, Terriente et al., 2008, Luque and Milan, 2007, Negre et al., 2006)
              no-ocelli
              (Tom et al., 2011)
              Secondary FlyBase IDs
              • FBgn0001971
              • FBgn0002947
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (145)