Itp-r83A, IP3R, IP3R, InsP3R, IP3 receptor
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.53
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Itpr using the Feature Mapper tool.
Itpr protein is detected in the second and third antennal segments as well as in the proboscis and the maxillary palps. In these locations, it is loclaized to the base of sensory hairs used for taste or olfaction. In the brain, it is restricted to cell bodies and is probably perinuclear. Itpr protein is observed associated with nuclei of each photoreceptor, cone and pigment cell. It is also present in the muscles of the head. In embryos, Itpr protein is observed in mesoderm. Protein is first observed at stage 9 and reaches a maximum in stage 13. It is present in somatic and visceral mesoderm and in two rows of cardioblasts along the dorsal midline. Staining begins to fade by stage 14. In the cephalic region, protein is observed in the procephalic mesoderm starting at stage 9 and is present in pharyngeal muscle by stage 13. In third instar larvae, Itpr protein is found in myoblasts in the wing and leg discs. In the eye disc, staining is associated with photoreceptor cells just behind the morphogenetic furrow. In pupae, Itpr protein was examined in the development of the DLMs. It is expressed in the myoblasts in the region of the DLMs and later in the fused myoblasts, and later still in the developing muscle fibres. Itpr protein is found to be expressed also in antennal muscles during their development.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Itpr in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Itp-r83A anon-WO02059370.49
Renamed from 'Itp-r83A' to 'Itpr' to follow common usage in the literature and because there's only a single Itpr gene in D. melanogaster (so no need to use '83A' as a distinguishing suffix).
Source for merge of Itp-r83A anon-WO02059370.49 was sequence comparison ( date:051113 ).
Itp-r83A-triggered calcium release is a signal that is necessary for both entry into mitosis and for anaphase onset in syncytial Drosophila embryos.
Both Itp-r83A and rut signalling pathways are involved in regulating larval molting. Regulation of 20-hydroxyecdysone peaks during larval molting may operate through a feedback loop requiring Pka-C1 and the Itp-r83A receptor.
Itp-r83A is essential for growth and differentiation, but does not play a role in the activation of the light response in photoreceptor cells.
Expression pattern analysis suggests that the IP3 signalling pathway is used during muscle development, primarily when myoblasts undergo rapid multiplication, in both embryos and pupae. In adults IP3 is probably a second messenger in more than one sensory transduction pathway.
The Drosophila IP3 receptor gene was cloned by PCR with degenerate oligonucleotides.
A cDNA for the inositol 1,4,5-tris-phosphate receptor by sequence similarity to the mouse gene. The Drosophila sequence was tested in NG108-15 transient assay and the protein encoded shown to bind 3H-inositol 1,4,5-tris-phosphate, showing functional similarity to the mouse protein.