FB2022_02, released March 29, 2022

Gene: Dmel\ATPsynβ

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General Information
Symbol
Dmel\ATPsynβ
Species
D. melanogaster
Name
ATP synthase, β subunit
Annotation Symbol
CG11154
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010217
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. (UniProt, Q05825)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

ATPsyn-beta, ATPsyn-β, ATP synthase-β, ATP synthase-beta, ATP synthase β subunit

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:1031484..1034917
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000194, InterPro:IPR020003
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
contributes_to proton-transporting ATP synthase activity, rotational mechanism
inferred from biological aspect of ancestor with PANTHER:PTN000389695
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:P00830
(FlyBase Curators, 2008-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in ATP synthesis coupled proton transport
inferred from sequence or structural similarity with UniProtKB:P00830
(FlyBase Curators, 2008-)
involved_in mitochondrial ATP synthesis coupled proton transport
inferred from biological aspect of ancestor with PANTHER:PTN000390017
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009, Alonso et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of mitochondrial proton-transporting ATP synthase complex
inferred from biological aspect of ancestor with PANTHER:PTN000390017
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of mitochondrial proton-transporting ATP synthase, catalytic core
inferred from sequence or structural similarity with UniProtKB:P00830
(FlyBase Curators, 2008-)
part_of proton-transporting ATP synthase complex, catalytic core F(1)
inferred from biological aspect of ancestor with PANTHER:PTN000389695
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ATPase alpha/beta chains family. (Q05825)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MITOCHONDRIAL COMPLEX V - ATP SYNTHASES -
Mitochondrial ATP synthase catalyzes the formation of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate (Pi) at the expense of the transmembrane electrochemical proton gradient generated by the respiratory electron transport chain. The components of this complex are divided into two separable sectors, F1 and F0. The catalytic F1 sector is located in the matrix and comprises subunits alpha, beta, gamma, delta and epsilon with stoichiometry of 3:3:1:1:1 . Alternating alpha and beta subunits form a hexameric ring that constitute the reactive centers that undergo conformational changes upon rotation of subunit gamma, leading to synthesis of ATP. The catalytic sites are located in the beta subunits. (Adapted from PMID:30888962 and PMID:31418131.)
Protein Function (UniProtKB)
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
(UniProt, Q05825)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\ATPsynβ for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q05825)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ATPsynβ-RA
FBtr0089186
NM_166808
1688
505
ATPsynβ-RC
FBtr0333672
NM_001272152
2026
511
ATPsynβ-RD
FBtr0344754
NM_001297790
2048
505
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ATPsynβ-PA
FBpp0088250
54.1
505
4.91
NP_726631
AAF59391
ATPsynβ-PC
FBpp0305828
54.7
511
4.91
NP_001259081
AGB96571
ATPsynβ-PD
FBpp0311086
54.1
505
4.91
NP_001284719
AHN58220
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

505 aa isoforms: ATPsynβ-PA, ATPsynβ-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

(UniProt, Q05825)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATPsynβ using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
adult stage | female
adult hemolymph
(Zeng et al., 2016)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009, Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ATPsynβ in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ATPsynβ
Transgenic constructs containing regulatory region of ATPsynβ
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATP5F1B
12 of 15
Yes
Yes
1  
Hsap\ATP5PB
1 of 15
No
No
Hsap\JARID2
1 of 15
No
No
Hsap\KDM5A
1 of 15
No
No
Hsap\KDM5B
1 of 15
No
No
Hsap\KDM5C
1 of 15
No
No
Hsap\KDM6A
1 of 15
No
No
Hsap\KDM6B
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atp5b
12 of 15
Yes
Yes
Mmus\Atp5f1
1 of 15
No
No
Mmus\Jarid2
1 of 15
No
No
1  
Mmus\Kdm5a
1 of 15
No
No
Mmus\Kdm5b
1 of 15
No
No
Mmus\Kdm5c
1 of 15
No
No
Mmus\Kdm5d
1 of 15
No
No
Mmus\Kdm6a
1 of 15
No
No
Mmus\Kdm6b
1 of 15
No
No
Mmus\Uty
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Atp5f1b
12 of 13
Yes
Yes
Rnor\Jarid2
1 of 13
No
No
Rnor\Kdm5a
1 of 13
No
No
Rnor\Kdm6b
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\atp5f1b
9 of 12
Yes
Yes
Xtro\jarid2
1 of 12
No
No
Xtro\kdm5a
1 of 12
No
No
Xtro\kdm5b
1 of 12
No
No
Xtro\kdm5c
1 of 12
No
No
Xtro\kdm6a
1 of 12
No
No
Xtro\kdm6b
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\atp5f1b
11 of 15
Yes
Yes
Drer\zgc:163069
2 of 15
No
Yes
Drer\jarid2a
1 of 15
No
No
Drer\jarid2b
1 of 15
No
No
Drer\kdm5ba
1 of 15
No
No
Drer\kdm5bb
1 of 15
No
No
Drer\kdm5c
1 of 15
No
No
Drer\kdm6a
1 of 15
No
No
Drer\kdm6al
1 of 15
No
No
Drer\kdm6ba
1 of 15
No
No
Drer\kdm6bb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\atp-2
12 of 15
Yes
Yes
Cele\asb-1
1 of 15
No
No
Cele\asb-2
1 of 15
No
No
Cele\jmjd-3.1
1 of 15
No
No
Cele\jmjd-3.2
1 of 15
No
No
Cele\jmjd-3.3
1 of 15
No
No
Cele\rbr-2
1 of 15
No
No
Cele\utx-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT5G08680
9 of 9
Yes
Yes
Atha\AT5G08690
9 of 9
Yes
Yes
Atha\AT5G08670
3 of 9
No
Yes
Atha\atpB
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\ATP2
13 of 15
Yes
Yes
Scer\ATP4
1 of 15
No
No
Scer\ECM5
1 of 15
No
No
Scer\JHD2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\atp2
11 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (9)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ATPsynβL
6 of 10
blw
1 of 10
Jarid2
1 of 10
Kdm5
1 of 10
Utx
1 of 10
Vha55
1 of 10
Vha68-1
1 of 10
Vha68-2
1 of 10
Vha68-3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ATP5F1B; ATP synthase F1 subunit beta
    12 of 15
    102910
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        RNA-protein
        Physical Interaction
        Assay
        References
        ATPsynβ - smg
        anti bait coimmunoprecipitation, primer specific pcr
        (Chartier et al., 2015)
        RNA-RNA
        Physical Interaction
        Assay
        References
        ATPsynβ - hpRNA:1
        quantitative reverse transcription pcr, rna cleavage, reverse transcription pcr
        (Wen et al., 2015)
        protein-protein
        Physical Interaction
        Assay
        References
        ATPsynβ - ATPsynB
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - ATPsynCF6
        blue native page, peptide massfingerprinting, experimental knowledge based
        (Rahman et al., 2014, Guruharsha et al., 2011)
        ATPsynβ - ATPsynD
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - ATPsynE
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - ATPsynF
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - ATPsynG
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - ATPsynO
        experimental knowledge based, blue native page, peptide massfingerprinting
        (Rahman et al., 2014, Guruharsha et al., 2011)
        ATPsynβ - ATPsynδ
        blue native page, peptide massfingerprinting, experimental knowledge based
        (Rahman et al., 2014, Guruharsha et al., 2011)
        ATPsynβ - Akt
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        ATPsynβ - AnxB10
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - CG10638
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Calr
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Chd64
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Cpr78E
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - Df31
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Egfr
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        ATPsynβ - Eno
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Fkbp12
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - GstO2
        enzymatic study, anti tag western blot
        (Kim et al., 2012)
        ATPsynβ - Hecw
        pull down, Identification by mass spectrometry
        (Fajner et al., 2021)
        ATPsynβ - HisRS
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Hsp83
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Invadolysin
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Di Cara et al., 2013)
        ATPsynβ - Mdh2
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Mhc
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Nacα
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Nlp
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Opa1
        anti bait coimmunoprecipitation, peptide massfingerprinting, western blot
        (Banerjee and Chinthapalli, 2014)
        ATPsynβ - Pdi
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Rdh1
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Rheb
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        ATPsynβ - SERCA
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - Sh3β
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - UQCR-C2
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - awd
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - blw
        blue native page, peptide massfingerprinting, experimental knowledge based
        (Rahman et al., 2014, Guruharsha et al., 2011)
        ATPsynβ - cid
        pull down, Identification by mass spectrometry, anti tag western blot
        (Collins et al., 2018)
        ATPsynβ - csw
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        ATPsynβ - drk
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        ATPsynβ - porin
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - regucalcin
        experimental knowledge based
        (Guruharsha et al., 2011)
        ATPsynβ - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        ATPsynβ - sun
        blue native page, peptide massfingerprinting
        (Rahman et al., 2014)
        ATPsynβ - vtd
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Ribeiro et al., 2016)
        ATPsynβ - βTub85D
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        hpRNA:1
        suppressible
        ATPsynβ
        (Wen et al., 2015)
        park
        enhanceable
        ATPsynβ
        (Kim et al., 2012)
        External Data
        Subunit Structure (UniProtKB)
        F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
        (UniProt, Q05825 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        4
        Recombination map
        4-0
        Cytogenetic map
        102F6-102F6
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        102F6-102F6
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        92C-92D
        (determined by in situ hybridisation)
        (Caggese et al., 1999)
        102D6-102D6
        (determined by in situ hybridisation)
        (Cuenca et al., 1998)
        Experimentally Determined Recombination Data
        Location

        4-0

        (FlyBase, 2016)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (12)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (827)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        monoclonal

        (Banerjee and Chinthapalli, 2014)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: ATPsynβ ATPsyn-β

        (Porcelli and Marygold, 2014.9.16)
        Source for database merge of
        Additional comments
        Other Comments

        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

        (Boutros et al., 2004)

        Homologous genetic loci in D.subobscura and D.melanogaster tend to show a similar ultrastructure in the two species.

        (Cuenca et al., 1998)

        Cloning and characterisation of ATPsyn-β and Dvir\ATPsyn-β. Comparison of the 5' regions reveals the presence of some conserved and non-conserved features that could be important in understanding how expression of the gene is controlled.

        (Pena et al., 1995)

        Steady state levels of ATPsyn-β RNA decrease as adult Drosophila age, and this change correlates with the shape of the life span curve.

        (Calleja et al., 1993)

        Cloning and characterisation of ATPsyn-β.

        (Pena and Garesse, 1993)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 109 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (48)
        Reported As
        Symbol Synonym
        ATP
        (Sheldahl et al., 2003)
        ATP syn-β
        (Di Cara et al., 2013, Lim et al., 2013)
        ATP-B
        (Parker et al., 2015)
        ATP-syn-B
        (Riddle et al., 2008)
        ATP-syn-β
        (Li et al., 2016)
        ATP-synβ
        (Curtis et al., 2007)
        ATP5B
        (Deng et al., 2018)
        ATP5F1B
        (Murari et al., 2021)
        ATP5β
        (Gonzalez and Wang, 2020)
        ATPB
        (Banerjee and Chinthapalli, 2014, Caggese et al., 2006, Mushegian et al., 1998)
        ATPase β
        (Matsushima and Kaguni, 2007)
        ATPase-β
        (Wang et al., 2014)
        ATPaseβ
        (Matsushima et al., 2010)
        ATPsyn
        (Brookheart et al., 2017)
        ATPsyn b
        (Dunn et al., 2001)
        ATPsyn-b
        (Chartier et al., 2015, Renfranz et al., 2003)
        ATPsyn-beta
        (Lee et al., 2016, Aradska et al., 2015, Chartier et al., 2015, Dent et al., 2015, Ashwal-Fluss et al., 2014, Chen et al., 2014, Lotz et al., 2014, Kwon et al., 2013, Zhang et al., 2013, Holderbaum et al., 2012.4.9, Riddle et al., 2012, Friedman et al., 2011, Müller et al., 2010, Wasbrough et al., 2010, Brower-Toland et al., 2009, Tan et al., 2009, Beller et al., 2006, Caggese et al., 2006, Tripoli et al., 2005, Giot et al., 2003, Moriyama and Powell, 1997)
        ATPsyn-β
        (Xu et al., 2019, Collins et al., 2018, Yan et al., 2014, Rees et al., 2011, Rera et al., 2010, Xun et al., 2008, Cermelli et al., 2006, Terhzaz et al., 2006, Sun et al., 2004)
        ATPsynbeta
        (Gene Disruption Project members, 2018-)
        ATPsynβ
        (Murari et al., 2021, Vásquez-Procopio et al., 2020, Weiner et al., 2020, Tsakiri et al., 2019, van den Ameele and Brand, 2019, Xu et al., 2019, Barry and Thummel, 2016, Ribeiro et al., 2016, Porcelli and Marygold, 2014.9.16)
        CG11154
        (Kolkhof et al., 2017, Hong and Choi, 2016, Rosa-Ferreira et al., 2015, Teixeira et al., 2015, Banerjee and Chinthapalli, 2014, Fukuoh et al., 2014, Jensen et al., 2013, Christis and Munro, 2012, Jaspers et al., 2012, Kim et al., 2012, Cammarato et al., 2011, Sun et al., 2011, Müller et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Puri et al., 2008, Porcelli et al., 2007, Cermelli et al., 2006, Terhzaz et al., 2006, Fulton et al., 2001)
        Comp V β
        (Thomas et al., 2014)
        complex Vβ
        (Pareek et al., 2018)
        dATP5B
        (Xu et al., 2019)
        β-ATPase
        (Baena-López et al., 2008, Schwarze et al., 1998, Calleja et al., 1993)
        Name Synonyms
        ATP SYNTHASE BETA CHAIN
        (Alonso et al., 2005)
        ATP Synthase beta
        (Panchal and Tiwari, 2020)
        ATP synthase
        (Sun et al., 2011)
        ATP synthase Beta chain
        (Tripoli et al., 2005)
        ATP synthase beta
        (Sheldahl et al., 2003)
        ATP synthase beta chain
        (Caggese et al., 2006)
        ATP synthase beta subunit
        (Garesse, 1993.2.24)
        ATP synthase beta-subunit
        (Wang et al., 2014)
        ATP synthase subunit beta
        (Vos et al., 2013)
        ATP synthase subunit beta, mitochondrial
        (Banerjee and Chinthapalli, 2014)
        ATP synthase subunit β
        (Hull et al., 2015)
        ATP synthase subunits β
        (Di Cara et al., 2013)
        ATP synthase β
        (Vos et al., 2012)
        ATP synthase β subunit
        (Ryuda et al., 2018, Parker et al., 2015, Matsushima and Kaguni, 2007)
        ATP synthase, β subunit
        (Porcelli and Marygold, 2014.9.16)
        ATP synthase-beta
        (Jaspers et al., 2012, Cammarato et al., 2011, Tan et al., 2009)
        ATP synthase-β
        (Hong and Choi, 2016, Wen et al., 2015, Pedersen et al., 2010, Cermelli et al., 2006)
        Complex V beta
        (Celotto et al., 2011)
        F0/F1 ATP synthase Beta
        (Porcelli et al., 2007)
        F1ATP synthase
        (Gandhi et al., 2004)
        H+-ATPase beta subunit
        (Garesse, 1995.3.28)
        Mitochondrial ATPsynβ
        (Hosamani et al., 2016)
        β-F1-ATPase
        (Ugalde et al., 2001)
        Secondary FlyBase IDs
          Datasets (8)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (8)
          Result
          Result Type
          Title
          scRNAseq_2020_Cattenoz_NI_seq_clustering
          Clustering analysis of hemocytes from non-infested third instar larvae
          scRNAseq_2020_Cattenoz_WI_seq_clustering
          Clustering analysis of hemocytes from wasp-infested third instar larvae
          scRNAseq_2020_Cho_NI72LG_seq_clustering
          Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
          scRNAseq_2020_Cho_NI96LG_seq_clustering
          Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
          scRNAseq_2020_Cho_NI120LG_seq_clustering
          Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
          scRNAseq_2020_Cho_WI96LG_seq_clustering
          Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
          scRNAseq_2020_Cho_NI96HL_seq_clustering
          Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
          scRNAseq_2020_Cho_NI120HL_seq_clustering
          Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
          References (153)