FlyBase Gene Report: Dmel\Klc

General Information

Symbol

Dmel\Klc

Species

D. melanogaster

Name

Kinesin light chain

Annotation Symbol

CG5433

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010235

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Kinesin light chain (Klc) encodes a component of the kinesin motor protein complex, which moves along microtubules to transport cytoplasmic "cargoes" such as mRNAs, protein complexes, and organelles. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

kinesin-1, kinesin

Key Links

Genomic Location

Cytogenetic map

69E1-69E1

Sequence location

3L:12,746,616..12,750,056 [-]

Recombination map

3-39

RefSeq locus

NT_037436 REGION:12746616..12750056

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9W0K0

(Taru et al., 2002)

inferred from physical interaction with UniProtKB:Q9GQF1

(Bowman et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables kinesin binding

inferred from biological aspect of ancestor with PANTHER:PTN002909199

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in dorsal appendage formation

inferred from mutant phenotype

(Hayashi et al., 2014)

involved_in microtubule-based movement

inferred from direct assay

(Ali et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in microtubule-based movement

inferred from biological aspect of ancestor with PANTHER:PTN002909199

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002909199

(GO Reference Genome Project, 2011-)

part_of kinesin complex

inferred from electronic annotation with InterPro:IPR002151

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the kinesin light chain family. (P46824)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

(UniProt, P46824)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Klc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P46824)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Klc-RA

FBtr0075951

NM_079325

1843

508

Klc-RB

FBtr0331555

NM_001274851

1841

508

Klc-RC

FBtr0331556

NM_001274852

1876

507

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Klc-PA

FBpp0075683

58.0

508

6.18

FBpp0303945

58.0

508

6.18

FBpp0303946

57.9

507

6.06

M9PFG7

NP_001261781

AGB94474

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

508 aa isoforms: Klc-PA, Klc-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Oligomeric complex composed of two heavy chains and two light chains.

(UniProt, P46824)

Domain

The light chain is composed of three structural domains: a large globular N-terminal domain which may be involved in binding to kinesin heavy chains, a central alpha-helical coiled-coil domain that mediates the light chain dimerization; and a small globular C-terminal which may play a role in regulating mechanochemical activity or attachment of kinesin to membrane-bound organelles.

(UniProt, P46824)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Klc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.78

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Klc in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Klc

View exonic expression by tissue for Dmel\Klc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010235

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010235

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010235

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010235

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5433

Flygut - An atlas of the Drosophila adult midgut

FBgn0010235

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Klc

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Klc

Transgenic constructs containing regulatory region of Klc

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)34ex5

(Horiuchi et al., 2005, Martin et al., 1999)

Df(3L)Exel6117

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

lethal - all die before end of pupal stage | recessive

Klc^59A

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Klc^GD11649

viable, with Scer\GAL4^Mef2.PR

Klc^GD11649

viable, with Scer\GAL4^pnr-MD237

Klc^GD11649

viable, with Scer\GAL4^tin.CΔ4

Klc^GD11649

Other Phenotypes

Allele

paralytic | larval stage | recessive

Klc^unspecified

some die during larval stage | recessive

some die during pupal stage | recessive

Klc^59A

visible

Klc^GD11649

visible, with Scer\GAL4^pnr-MD237

Klc^GD11649

Phenotype manifest in

Allele

calyx of larval mushroom body | somatic clone | third instar larval stage

Klc^8ex94

dendrite | somatic clone | third instar larval stage

Klc^8ex94

dorsal appendage | germline clone | maternal effect

Klc^sat

embryonic/larval mushroom body | third instar larval stage (with Klc^8ex94)

Klc^c02312

embryonic/larval mushroom body | third instar larval stage (with Klc^c02312)

Klc^8ex94

eye | somatic clone

Klc^8ex94

larval nervous system

Klc^8ex94

pedunculus of larval mushroom body | somatic clone | third instar larval stage

Klc^8ex94

trichogen cell, with Scer\GAL4^pnr-MD237

Klc^GD11649

wing blade | adult stage, with Scer\GAL4^RapGAP1-OK6

Klc^GD11649

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\KLC1

14 of 14

Yes

Hsap\KLC2

11 of 14

Yes

Hsap\KLC4

11 of 14

Yes

Hsap\KLC3

4 of 14

Yes

Hsap\APPBP2

2 of 14

Hsap\NPHP3

2 of 14

Yes

Hsap\TTC19

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Klc1

14 of 14

Yes

Rnor\Klc4

11 of 14

Yes

Rnor\Klc2

10 of 14

Yes

Rnor\Klc3

3 of 14

Yes

Rnor\Appbp2

2 of 14

Rnor\Nphp3

2 of 14

Yes

Rnor\Ttc19

2 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Klc1

14 of 14

Yes

Mmus\Klc4

11 of 14

Yes

Mmus\Klc2

10 of 14

Yes

Mmus\Klc3

3 of 14

Yes

Mmus\Appbp2

2 of 14

Mmus\Nphp3

2 of 14

Yes

Mmus\Ttc19

2 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\klc1

8 of 13

Yes

Xtro\klc4

5 of 13

Yes

Xtro\appbp2

1 of 13

Xtro\cfap20dc

1 of 13

Yes

Xtro\nphp3

1 of 13

Yes

Xtro\ttc19

1 of 13

Danio rerio (Zebrafish) (8)

Drer\klc1a

13 of 14

Yes

Drer\klc4

10 of 14

Yes

Drer\klc3

6 of 14

Yes

Drer\nphp3

2 of 14

Yes

Drer\ttc19

2 of 14

Drer\appbp2

1 of 14

Drer\klc1b

1 of 14

Yes

Drer\klc2

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\klc-2

13 of 14

Yes

Cele\klc-1

4 of 14

Yes

Cele\ddl-3

1 of 14

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP010258

12 of 12

Yes

Agam\AgaP_AGAP008033

2 of 12

Agam\AgaP_AGAP011356

2 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\AT5G37590

3 of 13

Yes

Atha\AT5G53080

2 of 13

Yes

Atha\KLCR1

2 of 13

Yes

Atha\KLCR3

2 of 13

Yes

Atha\AT2G31240

1 of 13

Yes

Atha\KLCR2

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Klc. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Pat1

3 of 13

Ttc19

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Klc^S433D

model of Alzheimer's disease 1

CEC

(Mórotz et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

KLC2; kinesin light chain 2

model of SPOAN syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Klc^8ex94

exacerbates Alzheimer's disease

modeled by Hsap\APP^695.T.UAS

(Gunawardena and Goldstein, 2001)

modeled by Hsap\APP^{695-Swedish.UAS}

(Gunawardena and Goldstein, 2001)

modeled by Hsap\APP^{695SPA4CT.UAS.Tag:MYC}

(Gunawardena and Goldstein, 2001)

modeled by Hsap\APP^{V717F.LOND.UAS}

(Gunawardena and Goldstein, 2001)

exacerbates neurodegenerative disease

modeled by htt^RNAi.UAS

(Gunawardena et al., 2003)

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Falzone et al., 2010)

modeled by Hsap\MAPT^UAS.cWa

(Falzone et al., 2010)

Klc^GD11649

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cIb

(Ueda et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KLC1; kinesin light chain 1

14 of 14

600025

KLC2; kinesin light chain 2

11 of 14

611729

SPASTIC PARAPLEGIA, OPTIC ATROPHY, AND NEUROPATHY; SPOAN

SPOAN syndrome

KLC4; kinesin light chain 4

11 of 14

620909

NEURODEGENERATION, EARLY-CHILDHOOD-ONSET, WITH RETINITIS PIGMENTOSA, SENSORINEURAL HEARING LOSS, AND DEMYELINATING PERIPHERAL NEUROPATHY; CONDRHN

KLC3; kinesin light chain 3

4 of 14

601334

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Klc - Aplip1

anti tag coimmunoprecipitation, anti tag western blot

(Horiuchi et al., 2007, Horiuchi et al., 2005, Taru et al., 2002)

Klc - Khc

coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry, anti bait coimmunoprecipitation, anti tag western blot, experimental knowledge based

(Veeranan-Karmegam et al., 2016, Winding et al., 2016, Guruharsha et al., 2011, Loiseau et al., 2010, Glater et al., 2006, Ling et al., 2004)

Klc - Naprt

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Pat1

anti tag coimmunoprecipitation, anti tag western blot

(Loiseau et al., 2010)

Klc - Prosα2

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosα4

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosα5

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosα6

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ1

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ2

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ3

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ4

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ5

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ6

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Prosβ7

experimental knowledge based

(Guruharsha et al., 2011)

Klc - Syt1

anti tag coimmunoprecipitation, western blot

(Shaw and Chang, 2013)

Klc - Unc-76

pull down, western blot

(Gindhart et al., 2003)

Klc - sw

pull down, western blot

(Reis et al., 2012)

Klc - tkv

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Klc

enhanceable

Appl

(Gunawardena and Goldstein, 2001)

Klc

enhanceable

mael

(Hayashi et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

DCTN2-p50

enhanceable

Klc

(Duncan and Warrior, 2002)

htt

enhanceable

Klc

(Gunawardena et al., 2003)

mael

enhanceable

Klc

(Hayashi et al., 2014)

suppressible

Klc

(Ehaideb et al., 2014)

External Data

Subunit Structure (UniProtKB)

Oligomeric complex composed of two heavy chains and two light chains.

(UniProt, P46824 )

Linkouts

BioGRID - A database of protein and genetic interactions.

64793

DroID - A comprehensive database of gene and protein interactions.

FBgn0010235

MIST (genetic) - An integrated Molecular Interaction Database

39445

MIST (protein-protein) - An integrated Molecular Interaction Database

39445

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-39

Cytogenetic map

69E1-69E1

Sequence location

3L:12,746,616..12,750,056 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69E1-69E1

Limits computationally determined from genome sequence between P{PZ}l(3)05088⁰⁵⁰⁸⁸ and P{PZ}l(3)06924⁰⁶⁹²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

69D-69D

(Gauger, 1993)

69D-69D

(determined by in situ hybridisation)

(Gauger and Goldstein, 1993)

Experimentally Determined Recombination Data

Location

3-39

(FlyBase, 2016)

3-33.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31997

w^*; Klc^8ex94/TM3, Sb¹

10883

w¹¹¹⁸; PBac{PB}Klc^c02312/TM6B, Tb¹

36795

y¹ sc^* v¹ sev²¹; P{TRiP.GL00535}attP40

42597

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02429}attP40

31996

w^*; P{lacW}Klc^59A P{FRT(w^hs)}2A/TM6B, Tb⁺

NIG-Fly

5433R-2

P{NIG.5433R}2

HMS02429

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02429}attP40/CyO

VDRC

v22125

w¹¹¹⁸; P{GD11649}v22125

v39583

w¹¹¹⁸; P{GD11649}v39583

v318316

PBac{fTRG00965.sfGFP-TVPTBF}VK00033

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD13018

Other clones

DPiM_LD13018

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010235

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010235

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mórotz et al., 2019, Duncan et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Khc is required for all cytoplasmic movements in the oocyte and for the posterior localisation of Dhc64C. Klc is not required for any of the functions of kinesin in the oocyte.

(Palacios and St. Johnston, 2002)

syd directly binds Klc via the Klc tetratricopeptide repeat.

(Bowman et al., 2000)

Loss of Klc function results in progressive lethargy, crawling defects, and paralysis followed by death at the end of the second larval instar stage. Klc mutant axons contain large aggregates of membranous organelles in segmental nerve axons.

(Gindhart et al., 1998)

Klc is an essential gene, with mutants dying during larval and pupal stages of development. A subset of alleles exhibit behavioural phenotype of sluggish crawling during the third larval instar. These phenotypes are similar to those of Khc mutants.

(Gindhart et al., 1995)

Isolated from a Drosophila head cDNA expression library using the Khc tail, which binds specifically to Klc in blot overlays, as a probe.

(Gauger and Goldstein, 1993)

Klc has been cloned and sequenced.

(Gauger and Goldstein, 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG5433

(Laffafian and Tepass, 2019, Kumar et al., 2016, Ni et al., 2011.7.19, Talmat-Amar et al., 2011, Ni et al., 2010.12.1, Hughes et al., 2008, Gandhi et al., 2007, Mount, 2001.8.14, Goldstein and Gunawardena, 2000)

DKLC

(Taru et al., 2002)

KLC

(Winding et al., 2016, Bouleau and Tricoire, 2015, Williams et al., 2014, Shaw and Chang, 2013, Fisher et al., 2012, Vazquez-Pianzola and Suter, 2012, Talmat-Amar et al., 2011, Glater et al., 2006, Ling, 2004, Ling et al., 2004, Gauger and Goldstein, 1993)

Kinesin

(Padilla et al., 2022)

Klc

(Beghelli et al., 2024, Sutton et al., 2024, Emond-Fraser et al., 2023, Loh et al., 2023, Lu and Gelfand, 2023, Zajac and Horne-Badovinac, 2022, Du et al., 2021, Jin et al., 2020, Witte et al., 2020, Zheng et al., 2020, Laffafian and Tepass, 2019, Mórotz et al., 2019, Kelliher et al., 2018, Lu et al., 2018, Russell et al., 2018, Walls et al., 2018, Kreko-Pierce and Eaton, 2017, Sarov et al., 2016, Appocher et al., 2014, Ehaideb et al., 2014, Luck et al., 2014, Schulman et al., 2014, Duncan et al., 2013, Gassman et al., 2013, Kwon et al., 2013, Gonsalvez and Long, 2012, Saxton and Hollenbeck, 2012, Friedman et al., 2011, Guest et al., 2011, Mochizuki et al., 2011, Loiseau et al., 2010, Boylan et al., 2008, Shubeita et al., 2008, Toda et al., 2008, Horiuchi et al., 2007, Vendra et al., 2007, Stanyon et al., 2004)

kinesin

(Carter and Cross, 2005, Molloy and Schmitz, 2005)

Name Synonyms

Kinesin 1 light chain

(Jolly et al., 2010)

Kinesin Light Chain

(Duncan et al., 2013, Talmat-Amar et al., 2011)

Kinesin light chain

(Goldman and Gonsalvez, 2017, Duncan et al., 2013, Gonsalvez and Long, 2012, Loiseau et al., 2010)

Kinesin-1

(Vendra et al., 2007)

kinesin

(Gindhart et al., 2005, Short et al., 2005, de Heredia and Jansen, 2004)

kinesin I

(Welte, 2004)

kinesin light chain

(Russell et al., 2018, Shaw and Chang, 2013, Vazquez-Pianzola and Suter, 2012, Mochizuki et al., 2011, Johnson et al., 2009, Ali et al., 2008, Boylan et al., 2008, Favors and Hales, 2008, Josowitz et al., 2008, Glater et al., 2006, Gauger, 1993, Gauger, 1993)

kinesin light chain subunit of kinesin-1

(Horiuchi et al., 2007)

kinesin-1

(Milas and Telley, 2022, Azevedo and Baylies, 2020, Reddy et al., 2017, Gunawardena et al., 2013, Benseñor et al., 2010, Horiuchi et al., 2007)

kinesin-1 light chain

(Fisher et al., 2012)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

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Result

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External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39445

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P46824

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P46824

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P46824

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010235

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39445/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010235

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010235

FlyMine - An integrated database for Drosophila genomics

FBgn0010235

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5433

MARRVEL_MODEL - MARRVEL (model organism gene)

39445

Linkouts

BioGRID - A database of protein and genetic interactions.

64793

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010235

DroID - A comprehensive database of gene and protein interactions.

FBgn0010235

DRSC - Results frm RNAi screens

FBgn0010235

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010235

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010235

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5433

Flygut - An atlas of the Drosophila adult midgut

FBgn0010235

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010235

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007992

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

MIST (genetic) - An integrated Molecular Interaction Database

39445

MIST (protein-protein) - An integrated Molecular Interaction Database

39445

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (180)

The following external sites may use different assemblies or annotations than FlyBase.

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