FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Akt
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General Information
Symbol
Dmel\Akt
Species
D. melanogaster
Name
Akt kinase
Annotation Symbol
CG4006
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010379
Gene Model Status
Current
Stock Availability
27 publicly available
Enzyme Name (EC)
Gene Summary
Akt kinase (Akt) encodes the core kinase component of the insulin/insulin-like growth factor pathway. It functions downstream of the product of Pi3K92E and is activated by phosphatidylinositol binding and phosphorylation. It regulates cell growth and survival, stress responses and ageing. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Akt1, dAkt, PKB, Dakt1, dPKB

Key Links
Genomic Location
Cytogenetic map
89B3-89B3
Sequence location
Recombination map
3-58
RefSeq locus
NT_033777 REGION:16099228..16105670
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (43 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9VJ07
(Gao et al., 2005)
enables protein serine/threonine kinase activity
inferred from mutant phenotype
(Borreguero-Muñoz et al., 2019, Puig et al., 2003, Staveley et al., 1998)
inferred from direct assay
(Bolukbasi et al., 2017, Wang et al., 2011, Hietakangas and Cohen, 2007, Potter et al., 2002, Radimerski et al., 2002, Scanga et al., 2000, Andjelkovic et al., 1995)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR017892
(InterPro Project Members, 2004-)
Biological Process (35 terms)
Terms Based on Experimental Evidence (34 terms)
CV Term
Evidence
References
involved_in cellular response to insulin stimulus
inferred from direct assay
(Hietakangas and Cohen, 2007, Radimerski et al., 2002)
involved_in cholesterol homeostasis
inferred from mutant phenotype
(Danielsen et al., 2016)
involved_in circadian rhythm
inferred from mutant phenotype
(Zheng et al., 2007)
involved_in dendrite regeneration
inferred from mutant phenotype
(Song et al., 2012)
involved_in epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Lavenburg et al., 2003)
involved_in insulin receptor signaling pathway
inferred from direct assay
(Tsao et al., 2023, Pereira et al., 2020, Hietakangas and Cohen, 2007, Wu et al., 2007, Kim et al., 2004, Radimerski et al., 2002, Scanga et al., 2000)
inferred from direct assay
(Verdu et al., 1999)
inferred from mutant phenotype
(Roth et al., 2018, Zhang et al., 2011, Kockel et al., 2010, Miron et al., 2003, Potter et al., 2002)
involved_in intracellular signal transduction
inferred from genetic interaction with UniProtKB:P91634
(Scanga et al., 2000)
involved_in lipid homeostasis
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011)
involved_in long-term synaptic depression
inferred from mutant phenotype
(Guo and Zhong, 2006)
acts_upstream_of_positive_effect multicellular organism growth
inferred from mutant phenotype
(Murillo-Maldonado et al., 2011)
acts_upstream_of negative regulation of apoptotic process
inferred from mutant phenotype
(Staveley et al., 1998)
involved_in negative regulation of hippo signaling
inferred from mutant phenotype
(Borreguero-Muñoz et al., 2019)
acts_upstream_of negative regulation of neuron apoptotic process
inferred from genetic interaction with FLYBASE:grim; FB:FBgn0015946
(Chuang et al., 2014)
involved_in negative regulation of peptide hormone secretion
inferred from mutant phenotype
(Park et al., 2014)
involved_in negative regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Natarajan et al., 2013)
involved_in negative regulation of triglyceride catabolic process
inferred from mutant phenotype
(Wang et al., 2011)
involved_in oogenesis
inferred from mutant phenotype
(Wei and Lilly, 2014)
involved_in open tracheal system development
inferred from mutant phenotype
(Jin et al., 2001)
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from direct assay
(Potter et al., 2002)
involved_in positive regulation of axon regeneration
inferred from mutant phenotype
(Song et al., 2012)
involved_in positive regulation of border follicle cell migration
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Sharma et al., 2018)
acts_upstream_of positive regulation of cell growth
inferred from mutant phenotype
(Roth et al., 2018, Lee and Chung, 2007)
inferred from mutant phenotype
(Potter et al., 2002)
involved_in positive regulation of cell growth
inferred from mutant phenotype
(Cavaliere et al., 2005, Scanga et al., 2000, Verdu et al., 1999)
acts_upstream_of positive regulation of cell population proliferation
inferred from genetic interaction with FLYBASE:Akt; FB:FBgn0010379
(Puig et al., 2003)
acts_upstream_of positive regulation of cell size
inferred from mutant phenotype
(Sims et al., 2009, Scanga et al., 2000, Verdu et al., 1999)
involved_in positive regulation of lipid storage
inferred from mutant phenotype
(Vereshchagina et al., 2008)
inferred from genetic interaction with FLYBASE:Pten; FB:FBgn0026379
(Vereshchagina and Wilson, 2006)
acts_upstream_of positive regulation of multicellular organism growth
inferred from genetic interaction with FLYBASE:Tl; FB:FBgn0262473
(Roth et al., 2018)
acts_upstream_of positive regulation of organ growth
inferred from mutant phenotype
(Scanga et al., 2000)
involved_in positive regulation of organ growth
inferred from mutant phenotype
(Verdu et al., 1999)
acts_upstream_of positive regulation of TORC1 signaling
inferred from mutant phenotype
(Kim et al., 2017)
involved_in regulation of dendrite development
inferred from mutant phenotype
(Parrish et al., 2009)
acts_upstream_of_positive_effect regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
acts_upstream_of_positive_effect regulation of multicellular organism growth
inferred from mutant phenotype
(Scanga et al., 2000)
involved_in response to oxidative stress
inferred from mutant phenotype
(Zheng et al., 2007)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Tsai et al., 2022)
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
(Sims et al., 2009)
inferred from direct assay
(Learte et al., 2008)
inferred from mutant phenotype
(Sopko et al., 2015)
involved_in wound healing, spreading of cells
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Tsai et al., 2022)
NOT involved_in positive regulation of cell population proliferation
inferred from mutant phenotype
(Verdu et al., 1999)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in insulin receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001219338
(GO Reference Genome Project, 2011-)
involved_in intracellular signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000683254
(GO Reference Genome Project, 2011-)
involved_in negative regulation of apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN001219338
(GO Reference Genome Project, 2011-)
involved_in positive regulation of blood vessel endothelial cell migration
inferred from biological aspect of ancestor with PANTHER:PTN001219338
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Vereshchagina and Wilson, 2006)
located_in cytosol
inferred from direct assay
(Vereshchagina et al., 2008, Vereshchagina and Wilson, 2006)
located_in neuronal cell body
inferred from direct assay
(Wong et al., 2013)
located_in nucleus
inferred from direct assay
(Vereshchagina and Wilson, 2006)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. (Q8INB9)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
Summaries
Gene Snapshot
Akt kinase (Akt) encodes the core kinase component of the insulin/insulin-like growth factor pathway. It functions downstream of the product of Pi3K92E and is activated by phosphatidylinositol binding and phosphorylation. It regulates cell growth and survival, stress responses and ageing. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
UNCLASSIFIED AGC KINASES -
This group comprises AGC kinases that do not classify under other groups in FlyBase.
Pathway (FlyBase)
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
PVR SIGNALING PATHWAY CORE COMPONENTS -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Serine/threonine kinase involved in various developmental processes (PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:11872800, PubMed:12172554, PubMed:12893776, PubMed:14525946, PubMed:15466161, PubMed:15712201, PubMed:9601646). During early embryogenesis, acts as a survival protein (PubMed:10962553, PubMed:9601646). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:24603715, PubMed:25329475, PubMed:29025897). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553).
(UniProt, Q8INB9)
Summary (Interactive Fly)

S/T kinase with Src homology 2 domain - promotes cell survival - component of insulin pathway

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Akt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8INB9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.55

Unconventional translation start (ACG) postulated; FBrf0079853.

Gene model reviewed during 5.54

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Akt-RA
FBtr0083227
NM_169706
3714
530
Akt-RB
FBtr0083226
NM_169707
3649
530
Akt-RC
FBtr0083228
NM_169705
3649
611
Akt-RD
FBtr0344470
NM_001300424
3301
530
Akt-RE
FBtr0344717
NM_001300425
4869
530
Additional Transcript Data and Comments
Reported size (kB)

3.9, 2.7 (northern blot)

(Andjelkovic et al., 1995)

4.0, 2.8 (northern blot)

(Franke et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Akt-PA
FBpp0082681
59.9
530
5.67
A0A0B4LIA3
NP_732114
AAF55275
Akt-PB
FBpp0082680
59.9
530
5.67
A0A0B4LIA3
NP_732115
AAF55276
Akt-PC
FBpp0082682
68.5
611
6.17
Q8INB9
NP_732113
AAN13699
Akt-PD
FBpp0310841
59.9
530
5.67
A0A0B4LIA3
NP_001287353
AHN57352
Akt-PE
FBpp0311050
59.9
530
5.67
A0A0B4LIA3
NP_001287354
AHN57353
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

530 aa isoforms: Akt-PA, Akt-PB, Akt-PD, Akt-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

611, 530 (aa); 60 (kD predicted)

(Andjelkovic et al., 1995)

530 (aa)

(Franke et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with trbl.

(UniProt, Q8INB9)
Post Translational Modification

Phosphorylated and activated by Pk61C/PDK1 (PubMed:11344272). Phosphorylated on Ser-586 by the TORC2 complex (PubMed:10962553, PubMed:15718470, PubMed:22493059).

(UniProt, Q8INB9)
Domain

Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.

(UniProt, Q8INB9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Akt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
indirect flight muscle cell
(Katti et al., 2017)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Andjelkovic et al., 1995)
(Franke et al., 1994)
embryonic stage -- adult stage
(Andjelkovic et al., 1995)
embryonic stage 1 -- 6
organism
(Andjelkovic et al., 1995)
pupal stage
(Franke et al., 1994)
adult stage | female
(Andjelkovic et al., 1995)
adult stage & oogenesis
nurse cell
(Andjelkovic et al., 1995)
Additional Descriptive Data

The 4kb Akt1 transcripts are detected throughout embryogenesis and larval stages on northern blots. They are also detected in pupal stages and in adult females. Akt transcripts are uniformly distributed at a high level in embryos and are observed in nurse cells during oogenesis.

(Andjelkovic et al., 1995)

Akt1 transcripts are detected in embryo RNA and weakly in pupal RNA.

(Franke et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
Reporter: P{PZ}Akt04226
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
tracheal primordium
(Jin et al., 2001)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Akt in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Akt
Transgenic constructs containing regulatory region of Akt
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
lethal, with Scer\GAL4hs.PB
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal | embryonic stage | germline clone | maternal effect
lethal | embryonic stage | maternal effect
lethal | heat sensitive, with Scer\GAL4Mef2.PR
lethal | larval stage
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4Mef2.PR
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during embryonic stage | maternal effect | recessive
partially lethal, with Scer\GAL4eya.enh1+E+2
partially lethal, with Scer\GAL4tin.CΔ4
partially lethal - majority die
partially lethal - majority die | recessive
viable
viable (with Akt1)
viable (with Akt3)
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female sterile, with Scer\GAL4VP16.nanos.UTR
female sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female sterile | recessive
Other Phenotypes
Allele
abnormal body size (with Akt1)
abnormal body size (with Akt04226)
abnormal body size | embryonic stage | recessive
abnormal body size | pupal stage | recessive
abnormal body size | recessive
abnormal cell death | embryonic stage | maternal effect | recessive
abnormal cell growth | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
abnormal cell size | recessive | somatic clone
abnormal circadian rhythm, with Scer\GAL4Lk6-DJ634
abnormal circadian rhythm, with Scer\GAL4tim.UAS
abnormal developmental rate
abnormal developmental rate | nutrition conditional
abnormal developmental rate | recessive
abnormal locomotor behavior | adult stage | male (with Akt04226)
abnormal locomotor behavior | adult stage | male (with AktMI14526)
abnormal locomotor behavior | larval stage (with Akt04226)
abnormal locomotor behavior | larval stage (with AktMI14526)
abnormal mating behavior | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4Toll-6-D42
abnormal neuroanatomy | adult stage, with Scer\GAL4pnr-MD237
abnormal neuroanatomy | larval stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | larval stage | somatic clone
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage (with Df(3R)Exel7328)
abnormal neurophysiology | adult stage (with Akt1)
abnormal neurophysiology | adult stage (with Akt3)
abnormal neurophysiology | recessive | third instar larval stage
abnormal neurophysiology | third instar larval stage, with Akt1
abnormal neurophysiology | third instar larval stage, with Akths.PS
abnormal neurophysiology | third instar larval stage (with Akt1)
abnormal neurophysiology | third instar larval stage (with Akt04226)
abnormal oxidative stress response, with Scer\GAL4Lk6-DJ634
abnormal oxidative stress response, with Scer\GAL4tim.UAS
abnormal planar polarity, with Scer\GAL471B
abnormal size, with Scer\GAL471B
abnormal size, with Scer\GAL4eya.enh1+E+2
abnormal size, with Scer\GAL4GMR.long
abnormal size, with Scer\GAL4GMR.PF
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL471B
abnormal size | adult stage, with Scer\GAL4dpp.blk1
abnormal size | adult stage, with Scer\GAL4GMR.PF
abnormal size | adult stage, with Scer\GAL4pnr-MD237
abnormal size | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
abnormal size | larval stage, with Scer\GAL471B
abnormal size | larval stage, with Scer\GAL4en-e16E
abnormal size | third instar larval stage, with Scer\GAL4hh.PU
abnormal starvation stress response | adult stage, with Scer\GAL4elav-C155
chemical resistant, with Scer\GAL4elav-C155
chemical sensitive, with Scer\GAL4elav-C155
decreased body size
decreased body size | adult stage (with Akt1)
decreased body size | adult stage (with Akt3)
decreased body size | nutrition conditional, with Scer\GAL4ppl.PP
decreased body size | recessive
decreased cell death, with Scer\GAL4hs.PB
decreased cell number, with Scer\GAL4nub-AC-62
decreased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
decreased cell number | third instar larval stage, with Scer\GAL4repo.PU
decreased cell size
decreased cell size, with Scer\GAL4nub-AC-62
decreased cell size, with Scer\GAL4ppl.PP
decreased cell size | adult stage | somatic clone, with Scer\GAL4Tub.PU
decreased cell size | larval stage, with Scer\GAL4insc-Mz1407
decreased cell size | somatic clone
decreased cell size | third instar larval stage, with Scer\GAL4repo.PU
decreased efficacy of long-term memory | adult stage, with Scer\GAL4GMR54H02
decreased occurrence of cell division | adult stage | RU486 conditional, with Scer\GAL4bun-GSG5961
decreased size | adult stage, with Scer\GAL4nub-AC-62, Scer\GAL80elav.PU
decreased size | larval stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
decreased size | oogenesis, with Scer\GAL4NP1624
decreased size | P-stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
decreased size | third instar larval stage, with Scer\GAL4repo.PU
hyperplasia, with Scer\GAL4GMR.PF
increased cell death | germline clone
increased cell death | oogenesis, with Scer\GAL4nanos.PG
increased cell death | third instar larval stage, with Scer\GAL4en-e16E
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased cell size, with Scer\GAL4en-e16E
increased cell size, with Scer\GAL4GMR.PF
increased cell size, with Scer\GAL4ppl.PP
increased cell size | adult stage, with Scer\GAL4GMR.PU
increased cell size | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | larval stage, with Scer\GAL4en-e16E
increased cell size | larval stage, with Scer\GAL4sns.PU
increased cell size | larval stage | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
increased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased cell size | somatic clone, with Scer\GAL4αTub84B.PP
increased cell size | third instar larval stage, with Scer\GAL4ppl.PP
long lived | RU486 conditional, with Scer\GAL4bun-GSG5961
short lived, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
some die during embryonic stage | recessive | maternal effect | recessive
some die during larval stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL471B
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4hs.2sev
visible | adult stage, with Scer\GAL4eya.enh1+E+2
visible | adult stage, with Scer\GAL4nub-AC-62, Scer\GAL80elav.PU
visible | adult stage (with Akt1)
visible | adult stage (with Akt3)
visible | recessive
visible | recessive | somatic clone
visible | somatic clone
wild-type
Phenotype manifest in
Allele
abdominal neuroblast, with Scer\GAL4insc-Mz1407
adult gut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
adult gut | RU486 conditional, with Scer\GAL4bun-GSG5961
adult head, with Scer\GAL4GMR.long
adult head capsule | somatic clone
adult midgut | somatic clone, with Scer\GAL4Tub.PU
adult midgut epithelium | somatic clone, with Scer\GAL4Tub.PU
dendrite | larval stage, with Scer\GAL4ppk.PG
dendrite | larval stage | somatic clone
egg chamber, with Scer\GAL4NP1624
embryo
embryonic/first instar larval cuticle | germline clone | maternal effect
embryonic/first instar larval cuticle | maternal effect
embryonic/larval fat body, with Scer\GAL4ppl.PP
embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PU
embryonic/larval garland cell | larval stage, with Scer\GAL4sns.PU
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage (with Df(3R)Exel7328)
embryonic/larval oenocyte | larval stage | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic/larval salivary gland, with Scer\GAL4hs.PB
embryonic/larval salivary gland, with Scer\GAL4ppl.PP
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4ppl.PP
embryonic myoblast
eye
eye, with Scer\GAL4eya.enh1+E+2
eye, with Scer\GAL4GMR.long
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye | somatic clone
fat body | somatic clone, with Scer\GAL4αTub84B.PP
fat cell | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
female germline stem cell, with Scer\GAL4nanos.PG
first posterior wing cell, with Scer\GAL4dpp.blk1
follicle cell, with Scer\GAL4NP1624
germarium, with Scer\GAL4nanos.PG
interommatidial bristle, with Scer\GAL4GMR.PF
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4Tub.PU
larval brain | third instar larval stage
larval brain | third instar larval stage, with Scer\GAL4repo.PU
larval glial cell | decreased number | third instar larval stage, with Scer\GAL4repo.PU
larval muscle system, with Scer\GAL4Mef2.PR
larval somatic muscle cell
mechanosensory neuron of posterior dorsocentral bristle, with Scer\GAL4pnr-MD237
neuromuscular junction | third instar larval stage, with Akt1
neuromuscular junction | third instar larval stage, with Akths.PS
neuromuscular junction | third instar larval stage (with Akt1)
neuromuscular junction | third instar larval stage (with Akt04226)
neuron projection | adult stage, with Scer\GAL4pnr-MD237
nucleolus | third instar larval stage, with Scer\GAL4repo.PU
nucleus | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PU
ommatidium (with Akt1)
ommatidium (with Akt3)
ommatidium | somatic clone
ovary, with Scer\GAL4NP1624
ovary, with Scer\GAL4VP16.nanos.UTR
P-body | oogenesis, with Scer\GAL4NP1624
rhabdomere | somatic clone
sarcomere, with Scer\GAL4Mef2.PR
segment border muscle cell
slit diaphragm | decreased number | larval stage, with Scer\GAL4sns.PU
synapse
synapse | adult stage, with Scer\GAL4pnr-MD237
synapse | increased number, with Scer\GAL4Toll-6-D42
tracheal branch primordium
tracheal branch primordium (with Df(3R)sbd45)
wing, with Scer\GAL471B
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4nub-AC-62, Scer\GAL80elav.PU
wing (with Akt1)
wing (with Akt3)
wing | posterior, with Scer\GAL4en-e16E
wing | P-stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
wing blade, with Scer\GAL4ap-md544
wing disc, with Scer\GAL471B
wing disc | larval stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing disc | somatic clone, with Scer\GAL4FRT.Act5C
wing disc | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PU
wing disc | third instar larval stage, with Scer\GAL4en-e16E
wing disc posterior compartment, with Scer\GAL4en-e16E
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en-e16E
wing disc posterior compartment | third instar larval stage, with Scer\GAL4hh.PU
wing hair, with Scer\GAL471B
wing hair | somatic clone
wing margin bristle | somatic clone, with Scer\GAL4Act5C.PI
wing vein, with Scer\GAL471B
wing vein | ectopic (with Akt1)
wing vein | ectopic (with Akt3)
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (125)
Hsap\AKT2
12 of 14
Yes
Yes
5  
Hsap\AKT3
11 of 14
No
Yes
Hsap\AKT1
10 of 14
No
Yes
1  
Hsap\SGK1
3 of 14
No
Yes
Hsap\SGK2
3 of 14
No
Yes
Hsap\SGK3
3 of 14
No
Yes
Hsap\C8orf44-SGK3
2 of 14
No
No
Hsap\PRKCA
2 of 14
No
No
Hsap\PRKCB
2 of 14
No
No
1  
Hsap\PRKCG
2 of 14
No
No
Hsap\PRKCI
2 of 14
No
No
Hsap\PRKCZ
2 of 14
No
No
Hsap\RPS6KB1
2 of 14
No
No
2  
Hsap\RPS6KB2
2 of 14
No
No
Hsap\ACAP2
1 of 14
No
No
Hsap\ACAP3
1 of 14
No
No
Hsap\ARHGAP22
1 of 14
No
No
Hsap\ARHGAP24
1 of 14
No
No
1  
Hsap\ARHGAP25
1 of 14
No
No
Hsap\BUB1B-PAK6
1 of 14
No
No
Hsap\CAMK1G
1 of 14
No
No
Hsap\CAMK2A
1 of 14
No
No
5  
Hsap\CAMK2D
1 of 14
No
No
1  
Hsap\CDC42BPA
1 of 14
No
No
Hsap\CDC42BPB
1 of 14
No
No
Hsap\CDC42BPG
1 of 14
No
No
Hsap\CHUK
1 of 14
No
No
Hsap\CIT
1 of 14
No
No
1  
Hsap\CYTH1
1 of 14
No
No
1  
Hsap\CYTH2
1 of 14
No
No
Hsap\CYTH3
1 of 14
No
No
Hsap\CYTH4
1 of 14
No
No
Hsap\DAPP1
1 of 14
No
Yes
Hsap\DMPK
1 of 14
No
No
5  
Hsap\GAB3
1 of 14
No
No
Hsap\GAB4
1 of 14
No
No
Hsap\GRK1
1 of 14
No
No
Hsap\GRK2
1 of 14
No
No
Hsap\GRK3
1 of 14
No
No
1  
Hsap\GRK4
1 of 14
No
No
2  
Hsap\GRK5
1 of 14
No
No
Hsap\GRK6
1 of 14
No
No
Hsap\GRK7
1 of 14
No
No
Hsap\IKBKB
1 of 14
No
No
1  
Hsap\IKBKE
1 of 14
No
No
1  
Hsap\IPCEF1
1 of 14
No
No
Hsap\LATS1
1 of 14
No
No
5  
Hsap\LATS2
1 of 14
No
No
4  
Hsap\MAP2K1
1 of 14
No
No
Hsap\MAP2K2
1 of 14
No
No
Hsap\MAP2K3
1 of 14
No
No
1  
Hsap\MAP2K4
1 of 14
No
No
Hsap\MAP2K5
1 of 14
No
No
Hsap\MAP2K6
1 of 14
No
No
1  
Hsap\MAP2K7
1 of 14
No
No
Hsap\MAP3K7
1 of 14
No
No
Hsap\MAP3K12
1 of 14
No
No
Hsap\MARK3
1 of 14
No
No
2  
Hsap\MAST1
1 of 14
No
No
Hsap\MAST2
1 of 14
No
No
Hsap\MAST3
1 of 14
No
No
Hsap\MAST4
1 of 14
No
No
Hsap\MYLK3
1 of 14
No
No
Hsap\MYLK4
1 of 14
No
No
Hsap\MYO10
1 of 14
No
No
Hsap\NEK4
1 of 14
No
No
Hsap\NEK8
1 of 14
No
No
Hsap\NEK9
1 of 14
No
No
1  
Hsap\OSBP2
1 of 14
No
No
Hsap\OSBP
1 of 14
No
No
Hsap\PAK1
1 of 14
No
No
Hsap\PAK3
1 of 14
No
No
Hsap\PAK6
1 of 14
No
No
Hsap\PDPK1
1 of 14
No
No
Hsap\PDPK2P
1 of 14
No
No
Hsap\PHETA1
1 of 14
No
No
1  
Hsap\PHETA2
1 of 14
No
No
Hsap\PKN1
1 of 14
No
No
Hsap\PKN2
1 of 14
No
No
Hsap\PKN3
1 of 14
No
No
Hsap\PLEK2
1 of 14
No
Yes
Hsap\PLEKHA1
1 of 14
No
Yes
Hsap\PLEKHA2
1 of 14
No
Yes
Hsap\PLEKHA5
1 of 14
No
No
Hsap\PLEKHA6
1 of 14
No
No
Hsap\PLEKHA7
1 of 14
No
No
Hsap\PLEKHH1
1 of 14
No
No
Hsap\PLEKHH2
1 of 14
No
No
Hsap\PRKACA
1 of 14
No
No
Hsap\PRKACB
1 of 14
No
No
Hsap\PRKACG
1 of 14
No
No
Hsap\PRKCD
1 of 14
No
No
Hsap\PRKCE
1 of 14
No
No
Hsap\PRKCH
1 of 14
No
No
Hsap\PRKCQ
1 of 14
No
No
Hsap\PRKD1
1 of 14
No
No
2  
Hsap\PRKD2
1 of 14
No
No
1  
Hsap\PRKD3
1 of 14
No
No
1  
Hsap\PRKG1
1 of 14
No
No
1  
Hsap\PRKG2
1 of 14
No
No
1  
Hsap\PRKX
1 of 14
No
No
Hsap\PRKY
1 of 14
No
No
Hsap\ROCK1
1 of 14
No
No
Hsap\ROCK2
1 of 14
No
No
1  
Hsap\RPS6KA1
1 of 14
No
No
Hsap\RPS6KA2
1 of 14
No
No
Hsap\RPS6KA3
1 of 14
No
No
1  
Hsap\RPS6KA4
1 of 14
No
No
Hsap\RPS6KA5
1 of 14
No
No
Hsap\RPS6KA6
1 of 14
No
No
1  
Hsap\RSKR
1 of 14
No
No
Hsap\SLK
1 of 14
No
No
6  
Hsap\STK3
1 of 14
No
No
1  
Hsap\STK4
1 of 14
No
No
2  
Hsap\STK10
1 of 14
No
No
Hsap\STK25
1 of 14
No
No
1  
Hsap\STK32A
1 of 14
No
No
1  
Hsap\STK32B
1 of 14
No
No
Hsap\STK32C
1 of 14
No
No
1  
Hsap\STK38
1 of 14
No
No
1  
Hsap\STK38L
1 of 14
No
No
1  
Hsap\TAOK1
1 of 14
No
No
Hsap\TAOK2
1 of 14
No
No
4  
Hsap\TAOK3
1 of 14
No
No
Hsap\TBK1
1 of 14
No
No
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (71)
Rnor\Akt2
12 of 14
Yes
Yes
Rnor\Akt1
11 of 14
No
Yes
Rnor\Akt3
11 of 14
No
Yes
Rnor\Sgk1
3 of 14
No
Yes
Rnor\Sgk2
3 of 14
No
Yes
Rnor\Sgk3
3 of 14
No
Yes
Rnor\Prkca
2 of 14
No
No
Rnor\Prkcb
2 of 14
No
No
Rnor\Prkcg
2 of 14
No
No
Rnor\Prkci
2 of 14
No
No
Rnor\Prkcz
2 of 14
No
No
Rnor\Rps6kb1
2 of 14
No
No
Rnor\Rps6kb2
2 of 14
No
No
Rnor\Camk1g
1 of 14
No
No
Rnor\Cdc42bpb
1 of 14
No
No
Rnor\Cdc42bpg
1 of 14
No
No
Rnor\Chuk
1 of 14
No
No
Rnor\Dmpk
1 of 14
No
No
Rnor\Grk1
1 of 14
No
No
Rnor\Grk2
1 of 14
No
No
Rnor\Grk3
1 of 14
No
No
Rnor\Grk4
1 of 14
No
No
Rnor\Grk5
1 of 14
No
No
Rnor\Grk6
1 of 14
No
No
Rnor\Ikbkb
1 of 14
No
No
Rnor\Ikbke
1 of 14
No
No
Rnor\Lats1
1 of 14
No
No
Rnor\Lats2
1 of 14
No
No
Rnor\Map3k12
1 of 14
No
No
Rnor\Map4k5
1 of 14
No
No
Rnor\MAST1
1 of 14
No
No
Rnor\Mast2
1 of 14
No
No
Rnor\Mast3
1 of 14
No
No
Rnor\Mast4
1 of 14
No
No
Rnor\Nek4
1 of 14
No
No
Rnor\Pak1
1 of 14
No
No
Rnor\Pak3
1 of 14
No
No
Rnor\Pdpk1
1 of 14
No
No
Rnor\Pheta1
1 of 14
No
No
Rnor\Pheta2
1 of 14
No
No
Rnor\Pkn1
1 of 14
No
No
Rnor\Pkn2
1 of 14
No
No
Rnor\Plk4
1 of 14
No
No
Rnor\Prkaca
1 of 14
No
No
Rnor\Prkacb
1 of 14
No
No
Rnor\Prkcd
1 of 14
No
No
Rnor\Prkce
1 of 14
No
No
Rnor\Prkch
1 of 14
No
No
Rnor\Prkcq
1 of 14
No
No
Rnor\Prkd1
1 of 14
No
No
Rnor\Prkd2
1 of 14
No
No
Rnor\Prkd3
1 of 14
No
No
Rnor\Prkg2
1 of 14
No
No
Rnor\Prkx
1 of 14
No
No
Rnor\Rock2
1 of 14
No
No
Rnor\Rps6ka1
1 of 14
No
No
Rnor\Rps6ka2
1 of 14
No
No
Rnor\Rps6ka3
1 of 14
No
No
Rnor\Rps6ka4
1 of 14
No
No
Rnor\Rps6ka5
1 of 14
No
No
Rnor\Rps6ka6
1 of 14
No
No
Rnor\Slk
1 of 14
No
No
Rnor\Stk10
1 of 14
No
No
Rnor\Stk25
1 of 14
No
No
Rnor\Stk32a
1 of 14
No
No
Rnor\Stk32b
1 of 14
No
No
Rnor\Stk32c
1 of 14
No
No
Rnor\Stk38l
1 of 14
No
No
Rnor\Stk38
1 of 14
No
No
Rnor\Taok2
1 of 14
No
No
Rnor\Tbk1
1 of 14
No
No
Mus musculus (laboratory mouse) (76)
Mmus\Akt2
12 of 14
Yes
Yes
Mmus\Akt1
11 of 14
No
Yes
Mmus\Akt3
10 of 14
No
Yes
Mmus\Sgk1
3 of 14
No
Yes
Mmus\Sgk2
3 of 14
No
Yes
Mmus\Sgk3
3 of 14
No
Yes
Mmus\Prkca
2 of 14
No
No
Mmus\Prkcb
2 of 14
No
No
Mmus\Prkcg
2 of 14
No
No
Mmus\Prkci
2 of 14
No
No
Mmus\Prkcz
2 of 14
No
No
3  
Mmus\Rps6kb1
2 of 14
No
No
Mmus\Rps6kb2
2 of 14
No
No
Mmus\Camk1g
1 of 14
No
No
Mmus\Cdc42bpb
1 of 14
No
No
Mmus\Cdc42bpg
1 of 14
No
No
Mmus\Chuk
1 of 14
No
No
Mmus\Dmpk
1 of 14
No
No
Mmus\Grk1
1 of 14
No
No
Mmus\Grk2
1 of 14
No
No
Mmus\Grk3
1 of 14
No
No
Mmus\Grk4
1 of 14
No
No
Mmus\Grk5
1 of 14
No
No
Mmus\Grk6
1 of 14
No
No
Mmus\Ikbkb
1 of 14
No
No
Mmus\Ikbke
1 of 14
No
No
Mmus\Lats1
1 of 14
No
No
Mmus\Lats2
1 of 14
No
No
Mmus\Map3k7
1 of 14
No
No
Mmus\Map3k12
1 of 14
No
No
Mmus\Map4k5
1 of 14
No
No
Mmus\Mast1
1 of 14
No
No
Mmus\Mast2
1 of 14
No
No
Mmus\Mast3
1 of 14
No
No
Mmus\Mast4
1 of 14
No
No
Mmus\Nek3
1 of 14
No
No
Mmus\Nek4
1 of 14
No
No
Mmus\Pak3
1 of 14
No
No
Mmus\Pdpk1
1 of 14
No
No
Mmus\Pheta1
1 of 14
No
No
Mmus\Pheta2
1 of 14
No
No
Mmus\Pkn1
1 of 14
No
No
Mmus\Pkn2
1 of 14
No
No
Mmus\Pkn3
1 of 14
No
No
Mmus\Plk4
1 of 14
No
No
Mmus\Prkaca
1 of 14
No
No
Mmus\Prkacb
1 of 14
No
No
Mmus\Prkcd
1 of 14
No
No
Mmus\Prkce
1 of 14
No
No
Mmus\Prkch
1 of 14
No
No
Mmus\Prkcq
1 of 14
No
No
Mmus\Prkd1
1 of 14
No
No
Mmus\Prkd2
1 of 14
No
No
Mmus\Prkd3
1 of 14
No
No
Mmus\Prkg1
1 of 14
No
No
Mmus\Prkg2
1 of 14
No
No
Mmus\Prkx
1 of 14
No
No
Mmus\Rock2
1 of 14
No
No
Mmus\Rps6ka1
1 of 14
No
No
Mmus\Rps6ka2
1 of 14
No
No
Mmus\Rps6ka3
1 of 14
No
No
Mmus\Rps6ka4
1 of 14
No
No
Mmus\Rps6ka5
1 of 14
No
No
Mmus\Rps6ka6
1 of 14
No
No
Mmus\Rskr
1 of 14
No
No
Mmus\Slk
1 of 14
No
No
Mmus\Stk10
1 of 14
No
No
Mmus\Stk25
1 of 14
No
No
Mmus\Stk32a
1 of 14
No
No
Mmus\Stk32b
1 of 14
No
No
Mmus\Stk32c
1 of 14
No
No
Mmus\Stk38l
1 of 14
No
No
Mmus\Stk38
1 of 14
No
No
Mmus\Stk39
1 of 14
No
No
Mmus\Taok2
1 of 14
No
No
Mmus\Tbk1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (66)
Xtro\akt2
8 of 13
Yes
Yes
Xtro\akt1
6 of 13
No
No
Xtro\prkcb
2 of 13
No
No
Xtro\sgk1
2 of 13
No
Yes
Xtro\sgk3
2 of 13
No
Yes
Xtro\a2ml1
1 of 13
No
No
Xtro\acap3
1 of 13
No
No
Xtro\aurkb
1 of 13
No
No
Xtro\camk2d
1 of 13
No
No
Xtro\chuk
1 of 13
No
No
Xtro\cit
1 of 13
No
No
Xtro\cnksr1
1 of 13
No
No
Xtro\cyth1
1 of 13
No
No
Xtro\dapp1
1 of 13
No
Yes
Xtro\dclk3
1 of 13
No
No
Xtro\dmpk
1 of 13
No
No
Xtro\gpha2
1 of 13
No
No
Xtro\grk1
1 of 13
No
No
Xtro\grk7
1 of 13
No
No
Xtro\ikbkb
1 of 13
No
No
Xtro\lats1
1 of 13
No
No
Xtro\lats2
1 of 13
No
No
Xtro\LOC100490294
1 of 13
No
Yes
Xtro\LOC100490663
1 of 13
No
No
Xtro\LOC100498055
1 of 13
No
No
Xtro\LOC101731388
1 of 13
No
Yes
Xtro\LOC101732362
1 of 13
No
No
Xtro\LOC101732839
1 of 13
No
No
Xtro\LOC101733298
1 of 13
No
No
Xtro\LOC101734050
1 of 13
No
Yes
Xtro\LOC105945216
1 of 13
No
Yes
Xtro\LOC105947923
1 of 13
No
Yes
Xtro\LOC116407815
1 of 13
No
Yes
Xtro\map2k1
1 of 13
No
No
Xtro\map4k5
1 of 13
No
No
Xtro\mast3
1 of 13
No
No
Xtro\myo10.2
1 of 13
No
No
Xtro\nek9
1 of 13
No
No
Xtro\pak3
1 of 13
No
No
Xtro\pkn2
1 of 13
No
No
Xtro\pkn3
1 of 13
No
No
Xtro\plekha1
1 of 13
No
Yes
Xtro\plekha4
1 of 13
No
No
Xtro\plk4
1 of 13
No
No
Xtro\plk5
1 of 13
No
No
Xtro\prkaca
1 of 13
No
No
Xtro\prkca
1 of 13
No
No
Xtro\prkcd
1 of 13
No
No
Xtro\prkcg
1 of 13
No
No
Xtro\prkci
1 of 13
No
No
Xtro\prkcq
1 of 13
No
No
Xtro\prkcz
1 of 13
No
No
Xtro\prkg1
1 of 13
No
No
Xtro\prkg2
1 of 13
No
No
Xtro\prkx
1 of 13
No
No
Xtro\ret
1 of 13
No
No
Xtro\rock1
1 of 13
No
No
Xtro\rps6ka3
1 of 13
No
No
Xtro\rskr
1 of 13
No
No
Xtro\sgk2
1 of 13
No
Yes
Xtro\stk3
1 of 13
No
No
Xtro\stk4
1 of 13
No
No
Xtro\stk10
1 of 13
No
No
Xtro\stk32c
1 of 13
No
No
Xtro\taok1
1 of 13
No
No
Xtro\tbk1
1 of 13
No
No
Danio rerio (Zebrafish) (103)
Drer\akt2
12 of 14
Yes
Yes
Drer\akt3b
11 of 14
No
Yes
Drer\akt2l
10 of 14
No
Yes
Drer\akt3a
9 of 14
No
Yes
Drer\akt1
4 of 14
No
Yes
Drer\sgk1
3 of 14
No
Yes
Drer\sgk2a
3 of 14
No
Yes
Drer\sgk3
3 of 14
No
Yes
Drer\si:ch211-195b13.1
3 of 14
No
Yes
Drer\prkcaa
2 of 14
No
No
Drer\prkcab
2 of 14
No
No
Drer\prkcba
2 of 14
No
No
Drer\prkcbb
2 of 14
No
No
Drer\prkcg
2 of 14
No
No
Drer\prkci
2 of 14
No
No
Drer\prkcz
2 of 14
No
No
Drer\rps6kb1b
2 of 14
No
No
Drer\sgk2b
2 of 14
No
No
Drer\aurkb
1 of 14
No
No
Drer\camk2d1
1 of 14
No
No
Drer\chuk
1 of 14
No
No
Drer\dmpk
1 of 14
No
No
Drer\grk1a
1 of 14
No
No
Drer\grk1b
1 of 14
No
No
Drer\grk3
1 of 14
No
No
Drer\grk4
1 of 14
No
No
Drer\grk5
1 of 14
No
No
Drer\grk5l
1 of 14
No
No
Drer\grk6
1 of 14
No
No
Drer\grk7a
1 of 14
No
No
Drer\grk7b
1 of 14
No
No
Drer\ikbkb
1 of 14
No
No
Drer\ikbke
1 of 14
No
No
Drer\lats1
1 of 14
No
No
Drer\lats2
1 of 14
No
No
Drer\LOC107980443
1 of 14
No
No
Drer\map3k12
1 of 14
No
No
Drer\mark2b
1 of 14
No
No
Drer\mark3a
1 of 14
No
No
Drer\mark4b
1 of 14
No
No
Drer\mast1a
1 of 14
No
No
Drer\mast1b
1 of 14
No
No
Drer\mast2
1 of 14
No
No
Drer\mast3a
1 of 14
No
No
Drer\mast3b
1 of 14
No
No
Drer\mylk3
1 of 14
No
No
Drer\mylk5
1 of 14
No
No
Drer\mylkb
1 of 14
No
No
Drer\nek4
1 of 14
No
No
Drer\nek8
1 of 14
No
No
Drer\nim1ka
1 of 14
No
No
Drer\pak2a
1 of 14
No
No
Drer\pak2b
1 of 14
No
No
Drer\pdpk1a
1 of 14
No
No
Drer\pdpk1b
1 of 14
No
No
Drer\pheta1
1 of 14
No
No
Drer\pheta2
1 of 14
No
No
Drer\pkn1a
1 of 14
No
No
Drer\pkn1b
1 of 14
No
No
Drer\pkn2a
1 of 14
No
No
Drer\prkacaa
1 of 14
No
No
Drer\prkacab
1 of 14
No
No
Drer\prkacba
1 of 14
No
No
Drer\prkacbb
1 of 14
No
No
Drer\prkcda
1 of 14
No
No
Drer\prkcdb
1 of 14
No
No
Drer\prkcea
1 of 14
No
No
Drer\prkceb
1 of 14
No
No
Drer\prkcha
1 of 14
No
No
Drer\prkchb
1 of 14
No
No
Drer\prkcq
1 of 14
No
No
Drer\prkd1
1 of 14
No
No
Drer\prkd2
1 of 14
No
No
Drer\prkd3
1 of 14
No
No
Drer\prkd4
1 of 14
No
No
Drer\prkg1a
1 of 14
No
No
Drer\prkg1b
1 of 14
No
No
Drer\prkg2
1 of 14
No
No
Drer\prkx
1 of 14
No
No
Drer\pskh1
1 of 14
No
No
Drer\rock1
1 of 14
No
No
Drer\rock2a
1 of 14
No
No
Drer\rps6ka1
1 of 14
No
No
Drer\rps6ka2
1 of 14
No
No
Drer\rps6ka3a
1 of 14
No
No
Drer\rps6ka3b
1 of 14
No
No
Drer\rps6ka4
1 of 14
No
No
Drer\rps6ka5
1 of 14
No
No
Drer\rps6kal
1 of 14
No
No
Drer\rps6kb1a
1 of 14
No
No
Drer\rskra
1 of 14
No
No
Drer\rskrb
1 of 14
No
No
Drer\si:dkey-81j8.6
1 of 14
No
No
Drer\si:dkey-192d15.2
1 of 14
No
No
Drer\slka
1 of 14
No
No
Drer\slkb
1 of 14
No
No
Drer\stk10
1 of 14
No
No
Drer\stk24a
1 of 14
No
No
Drer\stk38a
1 of 14
No
No
Drer\stk38b
1 of 14
No
No
Drer\stk38l
1 of 14
No
No
Drer\taok1a
1 of 14
No
No
Drer\tbk1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (47)
Cele\akt-1
11 of 14
Yes
Yes
Cele\akt-2
11 of 14
Yes
Yes
Cele\sgk-1
3 of 14
No
Yes
Cele\pkc-2
2 of 14
No
No
Cele\pkc-3
2 of 14
No
No
Cele\rsks-1
2 of 14
No
No
Cele\aak-2
1 of 14
No
No
Cele\C56G2.5
1 of 14
No
No
Cele\cst-1
1 of 14
No
No
Cele\cst-2
1 of 14
No
No
Cele\dapk-1
1 of 14
No
No
Cele\dkf-1
1 of 14
No
No
Cele\dkf-2
1 of 14
No
No
Cele\dyf-5
1 of 14
No
No
Cele\egl-4
1 of 14
No
No
Cele\F28C10.3
1 of 14
No
No
Cele\F31E3.2
1 of 14
No
No
Cele\F47F2.1
1 of 14
No
No
Cele\F49C5.4
1 of 14
No
No
Cele\gck-4
1 of 14
No
No
Cele\grk-1
1 of 14
No
No
Cele\grk-2
1 of 14
No
No
Cele\grp-1
1 of 14
No
No
Cele\kin-1
1 of 14
No
No
Cele\kin-4
1 of 14
No
No
Cele\kin-29
1 of 14
No
No
Cele\let-502
1 of 14
No
No
Cele\M03C11.1
1 of 14
No
No
Cele\max-1
1 of 14
No
No
Cele\mek-2
1 of 14
No
No
Cele\mlck-1
1 of 14
No
No
Cele\mrck-1
1 of 14
No
No
Cele\par-4
1 of 14
No
No
Cele\pdk-1
1 of 14
No
No
Cele\pkc-1
1 of 14
No
No
Cele\pkg-2
1 of 14
No
No
Cele\pkn-1
1 of 14
No
No
Cele\plk-2
1 of 14
No
No
Cele\R04A9.7
1 of 14
No
No
Cele\R06A10.4
1 of 14
No
No
Cele\rskn-1
1 of 14
No
No
Cele\rskn-2
1 of 14
No
No
Cele\sax-1
1 of 14
No
No
Cele\T24D5.4
1 of 14
No
No
Cele\tpa-1
1 of 14
No
No
Cele\W04B5.5
1 of 14
No
No
Cele\wts-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (53)
Agam\AgaP_AGAP002161
10 of 12
Yes
Yes
Agam\AgaP_AGAP000418
2 of 12
No
No
Agam\AgaP_AGAP002748
2 of 12
No
No
Agam\AgaP_AGAP011988
2 of 12
No
No
Agam\AgaP_AGAP012252
2 of 12
No
No
Agam\AgaP_AGAP000028
1 of 12
No
No
Agam\AgaP_AGAP000070
1 of 12
No
No
Agam\AgaP_AGAP000234
1 of 12
No
No
Agam\AgaP_AGAP000406
1 of 12
No
No
Agam\AgaP_AGAP000477
1 of 12
No
No
Agam\AgaP_AGAP000864
1 of 12
No
No
Agam\AgaP_AGAP001103
1 of 12
No
No
Agam\AgaP_AGAP001384
1 of 12
No
No
Agam\AgaP_AGAP001471
1 of 12
No
No
Agam\AgaP_AGAP001793
1 of 12
No
No
Agam\AgaP_AGAP001867
1 of 12
No
No
Agam\AgaP_AGAP001935
1 of 12
No
No
Agam\AgaP_AGAP003040
1 of 12
No
No
Agam\AgaP_AGAP003158
1 of 12
No
No
Agam\AgaP_AGAP003174
1 of 12
No
No
Agam\AgaP_AGAP003202
1 of 12
No
No
Agam\AgaP_AGAP003618
1 of 12
No
No
Agam\AgaP_AGAP004117
1 of 12
No
No
Agam\AgaP_AGAP005285
1 of 12
No
No
Agam\AgaP_AGAP005521
1 of 12
No
No
Agam\AgaP_AGAP006044
1 of 12
No
No
Agam\AgaP_AGAP006094
1 of 12
No
No
Agam\AgaP_AGAP006411
1 of 12
No
No
Agam\AgaP_AGAP006746
1 of 12
No
No
Agam\AgaP_AGAP007333
1 of 12
No
No
Agam\AgaP_AGAP007379
1 of 12
No
No
Agam\AgaP_AGAP007587
1 of 12
No
No
Agam\AgaP_AGAP007590
1 of 12
No
No
Agam\AgaP_AGAP008038
1 of 12
No
Yes
Agam\AgaP_AGAP008039
1 of 12
No
No
Agam\AgaP_AGAP008585
1 of 12
No
No
Agam\AgaP_AGAP008737
1 of 12
No
No
Agam\AgaP_AGAP008863
1 of 12
No
No
Agam\AgaP_AGAP009565
1 of 12
No
No
Agam\AgaP_AGAP009798
1 of 12
No
No
Agam\AgaP_AGAP010551
1 of 12
No
No
Agam\AgaP_AGAP010632
1 of 12
No
No
Agam\AgaP_AGAP010837
1 of 12
No
No
Agam\AgaP_AGAP010893
1 of 12
No
No
Agam\AgaP_AGAP011030
1 of 12
No
No
Agam\AgaP_AGAP011840
1 of 12
No
No
Agam\AgaP_AGAP011883
1 of 12
No
No
Agam\AgaP_AGAP012025
1 of 12
No
No
Agam\AgaP_AGAP012026
1 of 12
No
No
Agam\AgaP_AGAP012064
1 of 12
No
No
Agam\AgaP_AGAP012090
1 of 12
No
No
Agam\AgaP_AGAP012244
1 of 12
No
No
Agam\IKK1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (83)
Atha\AGC1.5
2 of 13
Yes
Yes
Atha\AGC1.7
2 of 13
Yes
Yes
Atha\AT2G44830
2 of 13
Yes
Yes
Atha\AT3G44610
2 of 13
Yes
Yes
Atha\AT5G40030
2 of 13
Yes
Yes
Atha\ATPK7
2 of 13
Yes
Yes
Atha\D6PK
2 of 13
Yes
Yes
Atha\D6PKL1
2 of 13
Yes
Yes
Atha\D6PKL2
2 of 13
Yes
Yes
Atha\KIPK
2 of 13
Yes
Yes
Atha\PID2
2 of 13
Yes
Yes
Atha\PID
2 of 13
Yes
Yes
Atha\PK1
2 of 13
Yes
No
Atha\RSH3
2 of 13
Yes
Yes
Atha\S6K2
2 of 13
Yes
No
Atha\WAG1
2 of 13
Yes
Yes
Atha\WAG2
2 of 13
Yes
Yes
Atha\AGC2-1
1 of 13
No
Yes
Atha\AT1G03920
1 of 13
No
No
Atha\AT1G30640
1 of 13
No
No
Atha\AT1G45160
1 of 13
No
No
Atha\AT1G48490
1 of 13
No
No
Atha\AT1G70430
1 of 13
No
No
Atha\AT2G19400
1 of 13
No
No
Atha\AT2G20050
1 of 13
No
No
Atha\AT2G20470
1 of 13
No
No
Atha\AT2G36350
1 of 13
No
Yes
Atha\AT2G37840
1 of 13
No
No
Atha\AT3G10540
1 of 13
No
No
Atha\AT3G17850
1 of 13
No
No
Atha\AT3G23310
1 of 13
No
No
Atha\AT4G13000
1 of 13
No
Yes
Atha\AT4G14350
1 of 13
No
No
Atha\AT4G33080
1 of 13
No
No
Atha\AT5G03640
1 of 13
No
Yes
Atha\AT5G05710
1 of 13
No
No
Atha\AT5G09890
1 of 13
No
No
Atha\AT5G18700
1 of 13
No
No
Atha\CDPK9
1 of 13
No
No
Atha\CDPK19
1 of 13
No
No
Atha\CIPK1
1 of 13
No
No
Atha\CIPK19
1 of 13
No
No
Atha\CPK1
1 of 13
No
No
Atha\CPK5
1 of 13
No
No
Atha\CPK6
1 of 13
No
No
Atha\CPK7
1 of 13
No
No
Atha\CPK9
1 of 13
No
No
Atha\CPK15
1 of 13
No
No
Atha\CPK18
1 of 13
No
No
Atha\CPK20
1 of 13
No
No
Atha\CPK21
1 of 13
No
No
Atha\CPK22
1 of 13
No
No
Atha\CPK26
1 of 13
No
No
Atha\CPK28
1 of 13
No
No
Atha\CPK30
1 of 13
No
No
Atha\CPK31
1 of 13
No
No
Atha\CPK32
1 of 13
No
No
Atha\CPK33
1 of 13
No
No
Atha\IRE
1 of 13
No
No
Atha\MAPKKK6
1 of 13
No
No
Atha\MAPKKK7
1 of 13
No
No
Atha\MAPKKK15
1 of 13
No
Yes
Atha\MAPKKK17
1 of 13
No
Yes
Atha\MEK1
1 of 13
No
No
Atha\MKK2
1 of 13
No
No
Atha\MKK3
1 of 13
No
No
Atha\MKK4
1 of 13
No
No
Atha\MKK5
1 of 13
No
No
Atha\MKK6
1 of 13
No
No
Atha\MKK7
1 of 13
No
No
Atha\MKK8
1 of 13
No
No
Atha\MKK9
1 of 13
No
No
Atha\MKK10
1 of 13
No
No
Atha\PDK1
1 of 13
No
No
Atha\PEPKR2
1 of 13
No
No
Atha\PH1
1 of 13
No
No
Atha\PHOT1
1 of 13
No
Yes
Atha\PHOT2
1 of 13
No
Yes
6  
Atha\SIK1
1 of 13
No
No
Atha\SIP1
1 of 13
No
No
Atha\SNRK2.7
1 of 13
No
No
Atha\UCN
1 of 13
No
Yes
Atha\UCNL
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (23)
Scer\SCH9
5 of 13
Yes
Yes
Scer\YPK1
3 of 13
No
No
Scer\YPK2
2 of 13
No
No
Scer\CBK1
1 of 13
No
No
Scer\DBF2
1 of 13
No
No
Scer\DBF20
1 of 13
No
No
Scer\FPK1
1 of 13
No
No
Scer\HSL1
1 of 13
No
No
Scer\KCC4
1 of 13
No
No
Scer\KIN82
1 of 13
No
No
Scer\MKK1
1 of 13
No
No
Scer\MKK2
1 of 13
No
No
Scer\PKC1
1 of 13
No
No
Scer\PKH1
1 of 13
No
No
Scer\PKH2
1 of 13
No
No
Scer\PKH3
1 of 13
No
No
Scer\RIM15
1 of 13
No
No
Scer\SPS1
1 of 13
No
No
Scer\STE7
1 of 13
No
No
Scer\TPK1
1 of 13
No
No
Scer\TPK2
1 of 13
No
No
Scer\TPK3
1 of 13
No
No
Scer\YPK3
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (17)
Spom\sck1
4 of 12
Yes
Yes
Spom\gad8
3 of 12
No
Yes
Spom\psk1
2 of 12
No
No
Spom\sck2
2 of 12
No
No
Spom\cdc7
1 of 12
No
Yes
Spom\ksg1
1 of 12
No
No
Spom\mug27
1 of 12
No
No
Spom\orb6
1 of 12
No
No
Spom\pck1
1 of 12
No
No
Spom\pck2
1 of 12
No
No
Spom\pka1
1 of 12
No
No
Spom\ppk14
1 of 12
No
Yes
Spom\ppk18
1 of 12
No
No
Spom\ppk21
1 of 12
No
No
Spom\ppk22
1 of 12
No
Yes
Spom\ppk33
1 of 12
No
No
Spom\sid2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Akt. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (54)
aPKC
4 of 13
inaC
4 of 13
Pkc53E
4 of 13
Pkc98E
4 of 13
Pkcδ
4 of 13
Pdk1
3 of 13
Pkn
3 of 13
CG32944
2 of 13
dop
2 of 13
S6k
2 of 13
trc
2 of 13
wts
2 of 13
bt
1 of 13
CaMKII
1 of 13
CG4839
1 of 13
CG12069
1 of 13
CG42271
1 of 13
CG43867
1 of 13
Drak
1 of 13
Dsor1
1 of 13
Erk7
1 of 13
for
1 of 13
GckIII
1 of 13
gek
1 of 13
Gprk1
1 of 13
Gprk2
1 of 13
gwl
1 of 13
hep
1 of 13
hpo
1 of 13
hppy
1 of 13
IKKβ
1 of 13
IKKε
1 of 13
IPIP
1 of 13
JIL-1
1 of 13
kmr
1 of 13
KP78a
1 of 13
lic
1 of 13
Nek2
1 of 13
Osbp
1 of 13
Pka-C1
1 of 13
Pka-C2
1 of 13
Pka-C3
1 of 13
PKD
1 of 13
Pkg21D
1 of 13
Rok
1 of 13
S6kII
1 of 13
S6KL
1 of 13
sff
1 of 13
Sik2
1 of 13
Slik
1 of 13
sqa
1 of 13
step
1 of 13
Strn-Mlck
1 of 13
Tao
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 7 )
Modifiers Based on Experimental Evidence ( 16 )
Allele
Disease
Interaction
References
AktHMS00007
ameliorates  cancer
modeled by ykiS111A.S168A.S250A.UAS.Tag:V5
(Lee et al., 2021)
exacerbates  frontotemporal dementia
modeled by Hsap\CHMP2BIntron5.UAS
(West et al., 2018)
AktHM04007
exacerbates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.cBa
(Na et al., 2023)
modeled by Hsap\APPAβ42.E693G.UAS.VTR
(Sharma et al., 2025)
AktGD1361
ameliorates  brain glioma
modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
(Read et al., 2009)
ameliorates  acute myeloid leukemia
modeled by Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa
(Sinenko et al., 2010)
Akt1
ameliorates  carcinoma
modeled by Ras85DV12.UAS, scrib1
(Igaki et al., 2006)
Akt3
exacerbates  frontotemporal dementia
modeled by Hsap\CHMP2BIntron5.UAS
(West et al., 2018)
AktEY10012
ameliorates  alcohol use disorder
modeled by aru8.128
(Eddison et al., 2011)
AktUAS.Exel
ameliorates  neurodegenerative disease
modeled by Hsap\HTTQ93.ex1.UAS
(Liévens et al., 2008)
ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
modeled by Zzzz\poly-GR80.UAS.Tag:FLAG
(Li et al., 2020)
modeled by Zzzz\poly-PR80.UAS.Tag:FLAG
(Li et al., 2020)
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.E693G.UAS.VTR
(Sharma et al., 2025)
ameliorates  cancer
modeled by Ras85DV12.QUAS.cLa, scribQUAS.HMS01490
(Bakopoulos et al., 2023)
AktUAS.Tag:HA
exacerbates  autosomal dominant cerebellar ataxia
modeled by Hsap\ATXN182Q.UAS
(Chen et al., 2003)
ameliorates  Huntington's disease
modeled by Hsap\HTT128Q.1-336.UAS
(Branco et al., 2008)
exacerbates  olivopontocerebellar atrophy
modeled by Hsap\ATXN182Q.UAS
(Branco et al., 2008)
AktT342D.S505D.GMR
ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
modeled by Zzzz\GGGGCC36.UAS
(Atilano et al., 2021)
Akt04226
ameliorates  autosomal dominant cerebellar ataxia
modeled by Hsap\ATXN182Q.UAS
(Chen et al., 2003)
exacerbates  Huntington's disease
modeled by Hsap\HTT128Q.1-336.UAS
(Branco et al., 2008)
ameliorates  olivopontocerebellar atrophy
modeled by Hsap\ATXN182Q.UAS
(Branco et al., 2008)
exacerbates  frontotemporal dementia
modeled by Hsap\CHMP2BIntron5.UAS
(West et al., 2018)
ameliorates  cancer
modeled by CskQ156Stop, Ras85DV12.UAS
(Hirabayashi et al., 2013)
ameliorates  carcinoma
modeled by CskQ156Stop, InRA1325D.UAS, Ras85DV12.UAS
(Hirabayashi and Cagan, 2015)
AktKK100495
ameliorates  acute myeloid leukemia
modeled by Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa
(Sinenko et al., 2010)
ameliorates  high grade glioma
modeled by Wdr62UAS.Tag:HA
(Shohayeb et al., 2020)
AktUAS.Tag:Myr(Unk)
ameliorates  glucose metabolism disease
modeled by Tl10b.UAS.cUa
(Roth et al., 2018)
AktT342D.UAS.Tag:HA
ameliorates  glucose metabolism disease
modeled by Tl10b.UAS.cUa
(Roth et al., 2018)
AktΔPH.UAS.Tag:Myr(Unk)
exacerbates  frontotemporal dementia
modeled by Hsap\CHMP2BIntron5.UAS
(West et al., 2018)
ameliorates  intestinal cancer
modeled by yki3SA.lexAop.sfGFP
(Saavedra et al., 2023)
ameliorates  cancer
modeled by yki3SA.lexAop.Tag:Myr(Unk),GFP
(Chen et al., 2022)
ameliorates  type 2 diabetes mellitus
modeled by UchKO
(Lee et al., 2024)
AktHMS06047
ameliorates  carcinoma
modeled by ykiHMS00041
(Bhattacharya et al., 2024)
AktRNAi.UAS.cUa
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.cUa
(Cheng et al., 2021)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
AKT2; AKT serine/threonine kinase 2
12 of 14
AKT SERINE/THREONINE KINASE 2; AKT2
 
AKT3; AKT serine/threonine kinase 3
11 of 14
611223
    AKT1; AKT serine/threonine kinase 1
    10 of 14
    164730
     
    SGK1; serum/glucocorticoid regulated kinase 1
    3 of 14
    602958
        SGK2; serum/glucocorticoid regulated kinase 2
        3 of 14
        607589
            SGK3; serum/glucocorticoid regulated kinase family member 3
            3 of 14
            607591
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Akt - ATPsynβ
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - ATPsynγ
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Act57B
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Afg3l2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Akap200
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Arc42
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Arf1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - AsnRS
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Atpα
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT4
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT5
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT6
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT7
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CCT8
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CG1416
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CG15784
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CG2614
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CG5504
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CG9281
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Chc
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - CtsK1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Desat1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Dref
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Drice
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Droj2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - FASN1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - GCS2β
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Gfat2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Gmppb
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - GstE7
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Hel25E
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Hsc70-2
                proximity ligation assay, fluorescence microscopy
                (Azuma et al., 2021)
                Akt - Hsc70-3
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Hsc70-5
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Hsp60A
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Ipo9
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Kap-α3
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Kcmf1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Ldh
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Lon
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Mcad
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - MetRS
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Mkk4
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Nap1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Nfs1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Nph
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Ogdh1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Ost1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Ost48
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - PCNA
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Pcb
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Pdha1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Pp2A-29B
                anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Psa
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Pyk
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rack1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rop
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpL17
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpL23
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpL31
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpL9
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpLP1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpS14a
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpS15Aa
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpS16
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpS17
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpS7
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - RpS9
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpn1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpn10
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpn13
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpn5
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpn9
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpt1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpt2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpt4
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpt5
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Rpt6
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - SERCA
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Sams
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Scox
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - ScsβA
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - ScsβG
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Shmt
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Sply
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Srlp
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - SsRβ
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - TER94
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Tctp
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Tkt
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Trmt2a
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - UQCR-C2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - Vha68-2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - ben
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - blw
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - cathD
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - clu
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - cpa
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - cpb
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - eEF1α1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - eEF2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - eIF2α
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - eIF2γ
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - eIF4A
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - eIF4G1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - fax
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - fkh
                anti tag coimmunoprecipitation, anti tag western blot
                (Bolukbasi et al., 2017)
                Akt - hts
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - l(1)G0320
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - l(2)09851
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - lic
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - mRpL12
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - mts
                anti tag coimmunoprecipitation, anti tag western blot
                (Gil-Ranedo et al., 2019)
                Akt - nst
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - pch2
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - pic
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - r-l
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - slmb
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot
                (Wong et al., 2013)
                Akt - smid
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - sqd
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - trbl
                pull down, autoradiography, anti bait coimmunoprecipitation, western blot, two hybrid
                (Fischer et al., 2025, Fischer et al., 2017, Das et al., 2014)
                Akt - tud
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - wal
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - wdb
                anti bait coimmunoprecipitation, western blot
                (Fischer et al., 2015, Vereshchagina et al., 2008)
                Akt - yki
                enzymatic study, western blot
                (Li et al., 2022)
                Akt - yps
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - αCOP
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - βTub60D
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - βTub97EF
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                Akt - δCOP
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Vinayagam et al., 2016)
                RNA-RNA
                Physical Interaction
                Assay
                References
                Akt - mir-263b
                luminiscence technology
                (Kim et al., 2025)
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Pdk1|Akt
                suppressible
                chrb
                (Reiling and Hafen, 2004)
                Akt
                suppressible
                egr
                (Tsuda et al., 2010)
                Akt
                suppressible
                foxo
                (Slade and Staveley, 2015, Junger et al., 2003)
                Akt
                enhanceable
                foxo
                (Slade and Staveley, 2015)
                Akt
                suppressible
                Gfat2
                (Mattila et al., 2018)
                Akt
                suppressible
                gig
                (Potter et al., 2002)
                Akt
                suppressible
                gig|Tsc1
                (Potter et al., 2002)
                Akt
                suppressible
                Girdin
                (Puseenam et al., 2009)
                Akt
                enhanceable
                hppy
                (Resnik-Docampo and de Celis, 2011)
                Pdk1|Akt
                suppressible
                Lk6
                (Reiling et al., 2005)
                Akt
                enhanceable
                Pdk1
                (Cho et al., 2001)
                Akt
                suppressible
                PRL-1
                (Urwyler et al., 2019)
                Akt
                suppressible
                Pss
                (Yang et al., 2019)
                Akt
                enhanceable
                Ptp61F
                (Tchankouo-Nguetcheu et al., 2014)
                Akt
                suppressible
                rictor
                (Lee and Chung, 2007)
                Akt|Pdk1
                enhanceable
                scyl
                (Reiling and Hafen, 2004)
                Pdk1|Akt
                suppressible
                scyl
                (Reiling and Hafen, 2004)
                Akt
                suppressible
                Sesn
                (Lee et al., 2010)
                Akt
                suppressible
                Thor
                (Miron et al., 2001)
                Akt
                suppressible
                Tl
                (Roth et al., 2018)
                Akt
                suppressible
                trbl
                (Das et al., 2014)
                Akt
                suppressible
                Tsc1
                (Wei and Lilly, 2014, Gao and Pan, 2001)
                Akt
                suppressible
                wdb
                (Funakoshi et al., 2011, Vereshchagina et al., 2008)
                Akt
                suppressible
                Wdr62
                (Shohayeb et al., 2020)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Acn
                enhanceable
                Akt
                (Nandi et al., 2014)
                acs|foxo
                suppressible
                Akt
                (Goberdhan et al., 2005)
                Atg9
                suppressible
                Akt
                (Wen et al., 2017)
                Atg9
                enhanceable
                Akt
                (Wen et al., 2017)
                Cds
                suppressible
                Akt
                (Liu et al., 2014)
                Crtc
                enhanceable
                Akt
                (Wang et al., 2008)
                Cul1
                suppressible
                Akt
                (Wong et al., 2013)
                CycG
                suppressible
                Akt
                (Fischer et al., 2015)
                Dcp-1
                enhanceable
                Akt
                (Kim et al., 2010)
                DJ-1α
                suppressible
                Akt
                (Yang et al., 2005)
                egh
                suppressible
                Akt
                (Dahlgaard et al., 2012)
                egr
                enhanceable
                Akt|POSH
                (Tsuda et al., 2010)
                Elp6
                suppressible
                Akt
                (Bolukbasi et al., 2012)
                foxo
                suppressible
                Akt
                (Kanao et al., 2010, Vereshchagina et al., 2008, Goberdhan et al., 2005, Kramer et al., 2003, Puig et al., 2003)
                foxo
                enhanceable
                Akt
                (Slade and Staveley, 2015)
                foxo|wdb
                suppressible
                Akt
                (Vereshchagina et al., 2008)
                Girdin
                enhanceable
                Akt
                (Puseenam et al., 2009)
                grim
                suppressible
                Akt
                (Chuang et al., 2014)
                grim
                enhanceable
                Akt
                (Chuang et al., 2014)
                hppy
                enhanceable
                Akt
                (Resnik-Docampo and de Celis, 2011)
                Ilp4
                suppressible
                Akt
                (de Tredern et al., 2021)
                kon
                suppressible
                Akt
                (Harrison et al., 2021)
                N
                suppressible
                Akt
                (Lee et al., 2013)
                ND-42
                suppressible
                Akt
                (Choo et al., 2015)
                ND-75
                suppressible
                Akt
                (Sinenko et al., 2011)
                path|foxo
                suppressible
                Akt
                (Goberdhan et al., 2005)
                Pdk1
                enhanceable
                Akt
                (Cho et al., 2001, Rintelen et al., 2001)
                Pdk1
                suppressible
                Akt
                (Cho et al., 2001, Rintelen et al., 2001)
                Pi3K92E
                suppressible
                Akt
                (Gass et al., 2022, Radimerski et al., 2002, Scanga et al., 2000)
                Pi3K92E
                enhanceable
                Akt
                (Radimerski et al., 2002)
                Pi3K92E|btl::Egfr
                suppressible
                Akt
                (Read et al., 2009)
                Pi3K92E|foxo
                suppressible
                Akt
                (Goberdhan et al., 2005)
                POSH|egr
                suppressible
                Akt
                (Tsuda et al., 2010)
                POSH|egr
                enhanceable
                Akt
                (Tsuda et al., 2010)
                PRL-1
                suppressible
                Akt
                (Urwyler et al., 2019)
                Pss
                suppressible
                Akt
                (Yang et al., 2019)
                Pten
                suppressible
                Akt
                (Mensah et al., 2015, Nowak et al., 2013, Vereshchagina et al., 2008, Pinal et al., 2006, Stocker et al., 2002, Gao et al., 2000)
                Ras85D|dlg1
                suppressible
                Akt
                (Willecke et al., 2011)
                Ras85D|scrib
                enhanceable
                Akt
                (Bakopoulos et al., 2023)
                Ras85D|scrib
                suppressible
                Akt
                (Bakopoulos et al., 2023, Igaki et al., 2006)
                REPTOR
                suppressible
                Akt
                (Saavedra et al., 2023)
                S6k
                suppressible
                Akt
                (Radimerski et al., 2002)
                scrib|cno
                suppressible
                Akt
                (Rives-Quinto et al., 2017)
                sl
                suppressible
                Akt
                (Murillo-Maldonado et al., 2011)
                spen
                suppressible
                Akt
                (Andriatsilavo et al., 2018)
                Tl
                suppressible
                Akt
                (Suzawa et al., 2019, Roth et al., 2018, Diangelo et al., 2009)
                trbl
                suppressible
                Akt
                (Das et al., 2014)
                trh
                suppressible
                Akt
                (Jin et al., 2001)
                Uch
                suppressible
                Akt
                (Lee et al., 2024)
                yki
                suppressible
                Akt
                (Saavedra et al., 2023)
                External Data
                Subunit Structure (UniProtKB)
                Interacts with trbl.
                (UniProt, Q8INB9 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                External Data
                Linkouts
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-58
                Cytogenetic map
                89B3-89B3
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                89B3-89B3
                Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                89B-89C
                (Franke, 1993.9.9)
                89B6-89B7
                (determined by in situ hybridisation)
                (Spradling et al., 1999, Perrimon et al., 1996)
                89B4-89B10
                (determined by in situ hybridisation)
                (Andjelkovic et al., 1995)
                89B6-89B7
                (BDGP Project Members, 1994-1999)
                89B-89C
                (determined by in situ hybridisation)
                (Franke et al., 1994)
                Experimentally Determined Recombination Data
                Location

                3-58

                (FlyBase, 2016)

                3-58.1

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (27)
                Genomic Clones (11)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (150)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Roth et al., 2018, Kockel et al., 2010, Andjelkovic et al., 1995)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      dsRNA made from templates generated with primers directed against this gene results in a reduction in cell size.

                      (Guertin et al., 2006)

                      dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.

                      (Yang et al., 2006)

                      dsRNA made from templates generated with primers directed against this gene does not significantly inhibit S6k phosphorylation in S2 cells.

                      (Yang et al., 2006)

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)

                      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become retracted (unspread but flat). Kc167 cells are unaffected.

                      (Kiger et al., 2003)

                      Btau\AKT1 is effective at rescuing Akt1 mutants, demonstrating Akt1 is as functional homolog of Btau\AKT1.

                      (Staveley et al., 1998)

                      Data implicates Akt1 as a cell survival gene.

                      (Staveley et al., 1998)

                      Mutants exhibit ectopic apoptosis during embryogenesis as judged by induction of membrane blebbing, DNA fragmentation and macrophage infiltration. Apoptosis caused by loss of Akt1 function is rescued by caspase suppression.

                      (Staveley et al., 1998)

                      Complementation group identified during genetic analysis of the pnr region.

                      (Heitzler et al., 1996)

                      The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

                      (Perrimon et al., 1996)

                      Akt1 has been cloned and sequenced.

                      (Andjelkovic et al., 1995, Franke et al., 1994)
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: Akt1 l(3)04226

                      (Spradling et al., 1999)

                      Source for merge of: l(3)89Bs Akt1

                      (Staveley et al., 1998)
                      Additional comments

                      Removed the '1' suffix from 'Akt1' because: (i) there is only one Akt gene in D. melanogaster, (ii) the encoded protein is not more similar to mammalian AKT1 vs AKT2/AKT3 (% amino acid similarity/identity is actually higher for AKT2/3), (iii) usage in the literature favours 'Akt' compared to 'Akt1'.

                      (FlyBase, 2009-)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: Akt1 CG4006

                      (Li, 1999.11)

                      Source for identity of: Akt Akt1

                      (FlyBase, 2009-)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (52)
                      Reported As
                      Symbol Synonym
                      AKT
                      (Nam and Jeong, 2025, Park et al., 2025, Feng et al., 2023, Lee et al., 2023, Li et al., 2023, Saavedra et al., 2023, Jarabo et al., 2022, Nayak and Mishra, 2022, Wang et al., 2022, Zhou et al., 2022, Bawa et al., 2021, Biglou et al., 2021, Chatterjee and Perrimon, 2021, Cheng et al., 2021, Dobens et al., 2021, Han et al., 2021, Hou and Pei, 2021, Prince et al., 2021, Sood et al., 2021, Voo et al., 2021, Arnés et al., 2020, Cheng et al., 2020, Fan et al., 2020, Hou et al., 2020, Kierdorf et al., 2020, Lee et al., 2020, Li et al., 2020, Mariano et al., 2020, Tang et al., 2020, Toprak et al., 2020, Towler et al., 2020, Ulgherait et al., 2020, Venugopal et al., 2020, Yuan et al., 2020, Chatterjee et al., 2019, Galenza and Foley, 2019, Hansen et al., 2019, Hwang et al., 2019, Jeong et al., 2019, Lang et al., 2019, Ryu et al., 2019, Kuo et al., 2018, Lee et al., 2018, Tang et al., 2018, Kang et al., 2017, Mattila and Hietakangas, 2017, Romero-Pozuelo et al., 2017, Sieber and Spradling, 2017, Tawo et al., 2017, Brill et al., 2016, Chen et al., 2016, Koyama and Mirth, 2016, Shen et al., 2016, Diop et al., 2015, Grifoni et al., 2015, Kohyama-Koganeya et al., 2015, Sanchez-Alvarez et al., 2015, Suh et al., 2015, Woodcock et al., 2015, Park et al., 2014, Wang et al., 2014, Andersen et al., 2013, Banerjee et al., 2013, Clark et al., 2013, Colca et al., 2013, Ferrandon, 2013, Gupta et al., 2013, Hada et al., 2013, Merkling and van Rij, 2013, Na et al., 2013, Nirala et al., 2013, Shim et al., 2013, Acebes et al., 2012, Homem and Knoblich, 2012, Lee et al., 2012, Murray et al., 2012, Wang et al., 2012, Harrison and Haddad, 2011, Resnik-Docampo and de Celis, 2011, Sun et al., 2011, Wang et al., 2011, Zhang et al., 2011, Ashton-Beaucage et al., 2010, Georgiev et al., 2010, Lee et al., 2010, Villa-Cuesta et al., 2010, Jones et al., 2009, Wu et al., 2009, Yan et al., 2009, Bakal et al., 2008, Kohyama-Koganeya et al., 2008, Liévens et al., 2008, Mattila et al., 2008, Hietakangas and Cohen, 2007, Hietakangas and Cohen, 2007, Schwartz and Pirrotta, 2007, Edgar, 2006, Liu and Lehmann, 2006, Leopold, 2004, Burgering and Kops, 2002, Morrison et al., 2000, Abrams, 1999, Spana and Perrimon, 1999)
                      AKT-1
                      (Tunçbilek et al., 2023, Han et al., 2021)
                      AKT/PKB
                      (Lenaerts et al., 2019, Colombani et al., 2005, Gingras et al., 2001)
                      AKT1
                      (Metaxakis et al., 2023, Aughey et al., 2014, Kanao et al., 2012, Papatheodorou et al., 2012, Kanao et al., 2010, Slack et al., 2010, Liévens et al., 2008)
                      Akt
                      (Adell et al., 2025, Dash and Mishra, 2025, El Marzkioui et al., 2025, He et al., 2025, Kharrat et al., 2025, Qin et al., 2025, Serebrovska et al., 2025, Simmons et al., 2025, Sun et al., 2025, Wang et al., 2025, Yu et al., 2025, Chen et al., 2024, Gera et al., 2024, Huang et al., 2024, Jans et al., 2024, Kim et al., 2024, Kosakamoto et al., 2024, Li et al., 2024, Mattila et al., 2024, Meng et al., 2024, Valzania et al., 2024, Yun et al., 2024, Bakopoulos et al., 2023, Baldenius et al., 2023, Banzai and Nishimura, 2023, Bland, 2023, Bonello et al., 2023, Chan et al., 2023, Dahleh et al., 2023, Frappaolo and Giansanti, 2023, Gui et al., 2023, Gumeni et al., 2023, Gupta et al., 2023, Hocaoglu and Sieber, 2023, Hou et al., 2023, Kim et al., 2023, Krama et al., 2023, Liu et al., 2023, Maurya and Tapadia, 2023, Meng et al., 2023, Pandey et al., 2023, Sriskanthadevan-Pirahas et al., 2023, Wippich et al., 2023, Zhou et al., 2023, Boulanger and Dura, 2022, Chen et al., 2022, Deshpande et al., 2022, Du et al., 2022, Eickelberg et al., 2022, Huang et al., 2022, Jiang et al., 2022, Li et al., 2022, Li et al., 2022, Noguchi et al., 2022, Ohhara and Yamanaka, 2022, Sheardown et al., 2022, Thangadurai et al., 2022, Yan et al., 2022, Yu et al., 2022, Zhao et al., 2022, Atilano et al., 2021, Azuma et al., 2021, Bailey et al., 2021, Dapergola et al., 2021, Gautam et al., 2021, Harrison et al., 2021, Jans et al., 2021, Kannangara et al., 2021, Keith et al., 2021, Liguori et al., 2021, Oliveira et al., 2021, Ostalé et al., 2021, Sciambra and Chtarbanova, 2021, Strassburger et al., 2021, Tortoriello et al., 2021, Wu et al., 2021, Yang et al., 2021, Zhang et al., 2021, Zhao et al., 2021, Bakshi and Joshi, 2020, Barretto et al., 2020, Christian and Benian, 2020, Cui et al., 2020, Ding et al., 2020, Jasper, 2020, Jeon et al., 2020, Karam et al., 2020, Khan et al., 2020, Lee et al., 2020, Lin and Hsu, 2020, Luckhart and Riehle, 2020, Na et al., 2020, Nakamura et al., 2020, Nishihara, 2020, Otsuki and Brand, 2020, Pan et al., 2020, Pastor-Pareja, 2020, P et al., 2020, Petruccelli et al., 2020, Polan et al., 2020, Rambur et al., 2020, Sudhakar et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Texada et al., 2020, Thanh et al., 2020, Vega-Cuesta et al., 2020, Yu et al., 2020, Ahlers et al., 2019, Chen et al., 2019, Gil-Ranedo et al., 2019, Gupta et al., 2019, Johnson and Stolzing, 2019, Kim and Choi, 2019, Post et al., 2019, Ryu et al., 2019, Texada et al., 2019, Westfall et al., 2019, Yang et al., 2019, Ahmad et al., 2018, Bednářová et al., 2018, Das et al., 2018, Huang and Wang, 2018, Ignesti et al., 2018, Kang et al., 2018, Lee et al., 2018, Lehmann, 2018, Mattila et al., 2018, Palmer et al., 2018, Richardson and Portela, 2018, Roth et al., 2018, Spéder and Brand, 2018, Swevers et al., 2018, Villegas et al., 2018, Brace and DiAntonio, 2017, Chang et al., 2017, Jordán-Álvarez et al., 2017, Kim et al., 2017, Liu and Jin, 2017, Mathew et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Warren et al., 2017, Wen et al., 2017, Wu et al., 2017, Yun et al., 2017, Alfa and Kim, 2016, Danielsen et al., 2016, David-Morrison et al., 2016, Hong et al., 2016, Jun et al., 2016, Niwa and Niwa, 2016, Padash Barmchi et al., 2016, Shen et al., 2016, Sieber et al., 2016, Vianna et al., 2016, Chen et al., 2015, Choo et al., 2015, Copf, 2015, Das and Dobens, 2015, Gross et al., 2015, Grotewiel and Bettinger, 2015, Huang et al., 2015, Jevtov et al., 2015, Kwon et al., 2015, Levayer et al., 2015, Nässel et al., 2015, Park et al., 2015, Rojas-Benitez et al., 2015, Song et al., 2015, Sopko et al., 2015, Ugrankar et al., 2015, Yan et al., 2015, Zaessinger et al., 2015, Alic et al., 2014, Banreti et al., 2014, Chuang et al., 2014, Evans et al., 2014, Ghosh et al., 2014, Gündner et al., 2014, Homem et al., 2014, Inamdar et al., 2014, Liu et al., 2014, Marzio et al., 2014, Moy et al., 2014, Mulakkal et al., 2014, Owusu-Ansah and Perrimon, 2014, Piccirillo et al., 2014, Schleich et al., 2014, Shimono et al., 2014, Wang et al., 2014, Xu and Cherry, 2014, Banerjee et al., 2013, Clark et al., 2013, Das et al., 2013, Das et al., 2013, Hirabayashi et al., 2013, Huang et al., 2013, Hwang et al., 2013, Kannan and Fridell, 2013, Karpac et al., 2013, Koyama et al., 2013, Lu and Johnston, 2013, Moy and Cherry, 2013, Na et al., 2013, Natarajan et al., 2013, O'Farrell et al., 2013, Oh et al., 2013, Pronovost et al., 2013, Shingleton and Frankino, 2013, Tamori and Deng, 2013, Tran et al., 2013, Wang et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Bier and Guichard, 2012, Bridon et al., 2012, Callan et al., 2012, Dahlgaard et al., 2012, Denton et al., 2012, Justiniano et al., 2012, Kapuria et al., 2012, Kuo et al., 2012, Lv et al., 2012, Marshall et al., 2012, Mirth and Shingleton, 2012, Nechipurenko and Broihier, 2012, Pallares-Cartes et al., 2012, Patel and Hardy, 2012, Rera et al., 2012, Song et al., 2012, Wang et al., 2012, Alic et al., 2011, Chun-Jen Lin et al., 2011, Friedman et al., 2011, Funakoshi et al., 2011, Gangaraju et al., 2011, Jones and Grotewiel, 2011, Miles et al., 2011, Mounir et al., 2011, Park et al., 2011, Partridge et al., 2011, Read, 2011, Sheldon et al., 2011, Tang et al., 2011, Willecke et al., 2011, Zhong et al., 2011, Birse et al., 2010, Biteau et al., 2010, Bjedov et al., 2010, Chell and Brand, 2010, Haselton et al., 2010, Maynard et al., 2010, Sabin et al., 2010, Sekine et al., 2010, Tiefenböck et al., 2010, Yamaguchi et al., 2010, Zheng and Sehgal, 2010, Hyun et al., 2009, Ikeya et al., 2009, Koike-Kumagai et al., 2009, Parrish et al., 2009, Puseenam et al., 2009, Qian and Bodmer, 2009, Read et al., 2009, Schleich and Teleman, 2009, Shelly et al., 2009, Ueishi et al., 2009, Walkiewicz and Stern, 2009, Wu et al., 2009, Branco et al., 2008, Buttrick et al., 2008, Choi et al., 2008, Dutta and Baehrecke, 2008, Lee et al., 2008, Lee et al., 2008, Simcox et al., 2008, Vereshchagina et al., 2008, Wang et al., 2008, Wang et al., 2008, Yu et al., 2008, Ahrens et al., 2007, Berry and Baehrecke, 2007, Dionne, 2007, Dionne and Schneider, 2007, Dong et al., 2007, Fuss et al., 2007, Hoshizaki and Gibbs, 2007, Jovceva et al., 2007, Lavery et al., 2007, Lee and Chung, 2007, Libert, 2007, Luo et al., 2007, Tseng et al., 2007, Wilson et al., 2007, Zheng et al., 2007, Zinke et al., 2007, Bjorklund et al., 2006, Dionne and Schneider, 2006, Dionne et al., 2006, Fuss et al., 2006, Hennig et al., 2006, Lavery and Stern, 2006, Lazzaro and Galac, 2006, Liu and Lehmann, 2006, Luo et al., 2006, Martin-Pena et al., 2006, Takacs-Vellai, 2006, Vereshchagina and Wilson, 2006, Wu and Brown, 2006, Wullschleger, 2006, Yang et al., 2006, Cavaliere et al., 2005, Gao et al., 2005, Shingleton, 2005, Dong and Pan, 2004, Pagliarini et al., 2004, Pan et al., 2004, Sherr, 2004, Neufeld, 2003, Puig et al., 2003, Anselmo et al., 2002, Davies, 2002, Potter et al., 2002, Gao and Pan, 2001, Jin et al., 2001, Lu et al., 2001, Potter and Xu, 2001, Potter et al., 2001, Potter et al., 2000, Scanga et al., 2000, Meier and Evan, 1998)
                      Akt-1
                      (Wang et al., 2022)
                      Akt/PKB
                      (Siudeja et al., 2007, Longo and Finch, 2003, Strauss, 2001)
                      Akt1
                      (Gujar and Wang, 2025, Klimkowski Arango and Morgante, 2025, Long et al., 2025, Nelson et al., 2025, Tamturk et al., 2025, Garcia et al., 2024, Reimels et al., 2024, Zirin et al., 2024, Sanal et al., 2023, Ziech et al., 2023, Chang et al., 2022, Huang et al., 2022, Miao et al., 2022, Ribot et al., 2022, Yue et al., 2022, Bilder et al., 2021, Clerbaux et al., 2021, Correa et al., 2021, de Tredern et al., 2021, Evans et al., 2021, Fabian et al., 2021, Harnish et al., 2021, Heier et al., 2021, Kim and O'Connor, 2021, Lee et al., 2021, Liang et al., 2021, Manola et al., 2021, Millington et al., 2021, Pang et al., 2021, Karageorgiou et al., 2020, Luo et al., 2020, Port et al., 2020, Zeng et al., 2020, Arbel et al., 2019, Chen and Read, 2019, Houtz et al., 2019, Li et al., 2019, Li et al., 2019, Manola et al., 2019, Meltzer et al., 2019, Xu et al., 2019, Yildirim et al., 2019, Ayala et al., 2018, Bai et al., 2018, Inoue et al., 2018, Merigliano et al., 2018, Muñoz-Soriano et al., 2018, Sharma et al., 2018, Katti et al., 2017, Mensah et al., 2017, Neuert et al., 2017, Park et al., 2017, Stobdan et al., 2017, Transgenic RNAi Project members, 2017-, Bhadra et al., 2016, Cinnamon et al., 2016, Crocker et al., 2016, Dobson et al., 2016, Fischer et al., 2016, Kaynar et al., 2016, Kuleesha et al., 2016, Lin et al., 2016, Musashe et al., 2016, Slade and Staveley, 2016, Vinayagam et al., 2016, Fischer et al., 2015, Kwon et al., 2015, Li et al., 2015, Mensah et al., 2015, Siudeja et al., 2015, Slade and Staveley, 2015, Das et al., 2014, Lam et al., 2014, Liu et al., 2014, Nandi et al., 2014, Park et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Tchankouo-Nguetcheu et al., 2014, Wei and Lilly, 2014, Das et al., 2013, Ibar et al., 2013, Kwon et al., 2013, Lanet et al., 2013, Lee et al., 2013, Lu and Johnston, 2013, Luo et al., 2013, Natarajan et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Alvarez-Ponce et al., 2012, Bolukbasi et al., 2012, Dahlgaard et al., 2012, Felix et al., 2012, Inamdar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Noebels et al., 2012, Rincon-Limas et al., 2012, Schoenherr et al., 2012, Tokusumi et al., 2012, Ye et al., 2012, Zhai et al., 2012, Eddison et al., 2011, Friedman et al., 2011, Leventis et al., 2011, Lindquist et al., 2011, Miles et al., 2011, Murillo-Maldonado et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Aron et al., 2010, Cook et al., 2010.1.8, Fernández-Ayala et al., 2010, Kim et al., 2010, Kühnlein, 2010, Reis et al., 2010, Robinson et al., 2010, Sinenko et al., 2010, Tsuda et al., 2010, Alvarez-Ponce et al., 2009, Demontis and Perrimon, 2009, Harbison et al., 2009, Nuzhdin et al., 2009, Sims et al., 2009, Tain et al., 2009, Branco et al., 2008, Kaplan et al., 2008, Zhou et al., 2008, Chan et al., 2007, Curtis et al., 2007, Dietzl et al., 2007, Palomero et al., 2007, Ramel et al., 2007, Zheng et al., 2007, Friedman and Perrimon, 2006, Pinal et al., 2006, Walker et al., 2006, Goberdhan et al., 2005, Terashima and Bownes, 2005, Stanyon et al., 2004, Folberg-Blum et al., 2002, Pickeral et al., 2000)
                      CG4006
                      (Trivedi et al., 2020, Neuert et al., 2017, Balakrishnan et al., 2015, Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2010.12.1, Demontis and Perrimon, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Morrison et al., 2000, Whitfield, 2000.5.15)
                      D-Akt
                      (Lavenburg et al., 2002, Scanga et al., 2000)
                      DAKT
                      (Das and Arur, 2017)
                      DAKT1
                      (Leevers, 1999)
                      DAKT1/PKB
                      (Claeys et al., 2002)
                      DAkt
                      (Orme et al., 2006)
                      DAkt1
                      (Weinkove and Leevers, 2000)
                      DPKB
                      (Coffer et al., 1998)
                      DRAC-PK
                      (Andjelkovic et al., 1995, Andjelkovic et al., 1994)
                      DRAC-PK66; DRAC-PK85
                      (Hemmnings, 1994.12.14)
                      Dakt
                      (Johnston and Gallant, 2002, Kohanski, 2002, Stocker and Hafen, 2000)
                      Dakt1
                      (Lavenburg et al., 2003, Aigaki et al., 2002, Potter et al., 2002, Cho et al., 2001, Downward and Leevers, 2001, Jin et al., 2001, Radimerski et al., 2001, Gao et al., 2000, Scanga et al., 2000, Wetsch et al., 2000, Edgar, 1999, Verdu et al., 1999, Verdu et al., 1999, Staveley et al., 1998, Franke et al., 1994, Franke, 1993.9.9)
                      Dkat1
                      (Millet-Boureima et al., 2021)
                      Dpkb
                      (Glatter et al., 2011)
                      P-AKT
                      (Hebbar et al., 2015)
                      P-Akt
                      (Lee et al., 2022)
                      PBB
                      (Toprak et al., 2020)
                      PKB
                      (Nowak et al., 2018, Mathew et al., 2017, Bader et al., 2013, Nowak et al., 2013, Alvarez-Ponce et al., 2012, Rincon-Limas et al., 2012, Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011, Oldham, 2011, Schiesari et al., 2011, Tiefenböck et al., 2010, Werz et al., 2009, Partridge et al., 2005, Reiling et al., 2005, Reiling and Hafen, 2004, Stocker et al., 2004, Nijhout, 2003, Reiling and Hafen, 2003, Stocker et al., 2003, Wittwer et al., 2003, Kozma and Thomas, 2002, McManus and Alessi, 2002, Saucedo and Edgar, 2002, Towers and Sattelle, 2002, Clancy et al., 2001, Downward and Leevers, 2001, Jin et al., 2001, Lawlor and Alessi, 2001, Wells, 2001, Lehner, 1999, Spana and Perrimon, 1999, Stambolic et al., 1999)
                      PKB/AKT
                      (Findlay et al., 2005, Staveley et al., 1998)
                      PKB/Akt
                      (Clague et al., 2004)
                      PKB/dAKT
                      (Ghabrial et al., 2003)
                      RAC
                      (Wallingford and Habas, 2005, Jones et al., 1992)
                      RacPK
                      akt
                      (Zhang et al., 2025, Datta and Bangi, 2024, Fangninou et al., 2024, Gao et al., 2024, Liu et al., 2024, Datta et al., 2023, Ito and Igaki, 2021, Shohayeb et al., 2020, Borreguero-Muñoz et al., 2019, Funakoshi et al., 2018, Ghiglione et al., 2018, Di Cara and King-Jones, 2016, Xu et al., 2016, Hirabayashi and Cagan, 2015, Parker and Struhl, 2015, Bardet et al., 2013, Hirabayashi et al., 2013, Karpac et al., 2013, Nechipurenko and Broihier, 2012, Parrish et al., 2009, Guo and Zhong, 2006, Potter et al., 2001)
                      akt1
                      (Deichsel et al., 2024, Ghosh et al., 2020, Sun et al., 2020, Tsakiri et al., 2017, Marmor-Kollet and Schuldiner, 2016, Davidson et al., 2009, Buttrick et al., 2008, Coffman et al., 2005)
                      dAKT
                      (Wang et al., 2022, Kim et al., 2020, Toshniwal et al., 2019, Westfall et al., 2019, Bolukbasi et al., 2017, Lee et al., 2013, Wu et al., 2013, Delanoue et al., 2010, Song et al., 2007, Dekanty et al., 2005, Kim et al., 2004)
                      dAKT/dPKB
                      (Sarbassov et al., 2005)
                      dAKT1
                      (Moon et al., 2006)
                      dAkt
                      (Antonica et al., 2022, Chakrabarty et al., 2022, Weina et al., 2022, Álvarez-Rendón et al., 2018, Gruntenko and Rauschenbach, 2018, Westfall et al., 2018, Fischer et al., 2017, Wakabayashi et al., 2016, Chen et al., 2015, Kayashima et al., 2013, Luo et al., 2013, Velentzas et al., 2013, Kamakura, 2011, Klusza and Deng, 2011, Lindquist et al., 2011, Zhong et al., 2011, Slack et al., 2010, Song et al., 2010, Cliffe et al., 2009, Diangelo et al., 2009, Read et al., 2009, DiAngelo et al., 2008, Kim et al., 2008, Porstmann et al., 2008, DiAngelo and Birnbaum, 2007, Lasko and Sonenberg, 2007, Guertin et al., 2006, Yang et al., 2006, Kockel et al., 2005, Hay and Sonenberg, 2004, Jorgensen and Tyers, 2004, Maehama et al., 2004, Wheeler et al., 2004, Cavaliere et al., 2003, Cavaliere et al., 2003, Hafen and Stocker, 2003, Jacinto and Hall, 2003, Kramer et al., 2003, Lee et al., 2003, Manning and Cantley, 2003, Miron et al., 2003, Pagliarini and Xu, 2003, Marygold and Leevers, 2002, Stocker et al., 2002, Keyes et al., 1999)
                      dAkt/PKB
                      (Frias et al., 2006, Stocker et al., 2003)
                      dAkt1
                      (Altintas et al., 2016, Sanchez et al., 2016, Mitchell et al., 2015, Cortina-Andrada et al., 2007, Igaki et al., 2006, Igaki et al., 2006, Inoki and Guan, 2006, Shi et al., 2005, Chen et al., 2003, Bradley et al., 2001, Miron et al., 2001, Rintelen et al., 2001, Coelho and Leevers, 2000)
                      dPKB
                      (Liu and Lehmann, 2006, Wittwer et al., 2005, Junger et al., 2003, Oldham and Hafen, 2003, Radimerski et al., 2002, Radimerski et al., 2002, Radimerski et al., 2002, Oldham et al., 2000)
                      dakt
                      (Constantinou et al., 2016, Kockel et al., 2010, Guo and Zhong, 2006)
                      dakt1
                      (Nunez and del Peso, 1998)
                      l(3)04226
                      (Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)
                      l(3)89Bq
                      (Lu et al., 2001, Heitzler et al., 1996)
                      p-Akt
                      (Howlett et al., 2008)
                      pAkt
                      (Simcox et al., 2008)
                      Name Synonyms
                      Akt kinase
                      (Nechipurenko and Broihier, 2012)
                      Akt1
                      (Aron et al., 2010)
                      Protein kinase B
                      (Terashima and Bownes, 2005)
                      RAC serine/threonine protein kinase
                      (Xu et al., 2016)
                      Related to PKA to PKC protein kinases
                      (Andjelkovic et al., 1994)
                      dAkt kinase
                      (Cavaliere et al., 2005)
                      related to the A and C kinases
                      (Jones et al., 1992)
                      Secondary FlyBase IDs
                      • FBgn0010837
                      • FBgn0013324
                      • FBgn0017365
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 126 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      References (963)