FlyBase Gene Report: Dmel\Nmdar1

General Information

Symbol

Dmel\Nmdar1

Species

D. melanogaster

Name

NMDA receptor 1

Annotation Symbol

CG2902

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010399

Gene Model Status

Current

Stock Availability

46 publicly available

Gene Summary

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (UniProt, Q24418)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dNR1, NMDAR, NR1, NMDA, NMDA receptor

Key Links

Genomic Location

Cytogenetic map

83A6-83A7

Sequence location

3R:5,508,842..5,523,328 [-]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5508842..5523328

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to NMDA glutamate receptor activity

inferred from direct assay

(Xia et al., 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ligand-gated monoatomic ion channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594

(InterPro Project Members, 2004-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR001508

(InterPro Project Members, 2004-)

contributes_to NMDA glutamate receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

enables NMDA glutamate receptor activity

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001508

(InterPro Project Members, 2004-)

Biological Process (12 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

involved_in associative learning

inferred from direct assay

(Qin and Dubnau, 2010)

involved_in behavioral response to ethanol

inferred from mutant phenotype

(Maiya et al., 2012)

involved_in calcium ion homeostasis

inferred from mutant phenotype

(Xia et al., 2005)

involved_in chemical synaptic transmission

inferred from mutant phenotype

(Xia et al., 2005)

involved_in ionotropic glutamate receptor signaling pathway

inferred from direct assay

(Xia et al., 2005)

involved_in long-term memory

inferred from mutant phenotype

(Miyashita et al., 2012, Wu et al., 2007, Xia et al., 2005)

inferred from genetic interaction with FLYBASE:Nmdar2; FB:FBgn0053513

(Chen et al., 2012)

involved_in medium-term memory

inferred from mutant phenotype

(Wu et al., 2007)

involved_in olfactory learning

inferred from mutant phenotype

(Xia et al., 2005)

inferred from genetic interaction with FLYBASE:PQBP1; FB:FBgn0039270

(Tamura et al., 2010)

involved_in phototaxis

inferred from direct assay

(Zhou et al., 2010)

involved_in regulation of membrane potential

inferred from mutant phenotype

(Xia et al., 2005)

involved_in sensory perception of touch

inferred from mutant phenotype

(Tsubouchi et al., 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

involved_in ionotropic glutamate receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR001508

(InterPro Project Members, 2004-)

involved_in regulation of membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of ionotropic glutamate receptor complex

inferred from physical interaction with FLYBASE:Nmdar2; FB:FBgn0053513

(Xia et al., 2005)

located_in membrane

inferred from direct assay

(Xia et al., 2005)

part_of NMDA selective glutamate receptor complex

inferred from direct assay

(Xia et al., 2005)

located_in postsynaptic membrane

inferred from direct assay

(Xia et al., 2005)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR001508, InterPro:IPR019594

(InterPro Project Members, 2004-)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

part_of NMDA selective glutamate receptor complex

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(GO Reference Genome Project, 2011-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN001451205

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NMDA IONOTROPIC GLUTAMATE RECEPTORS

Protein Family (UniProt)

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (Q24418)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NMDA IONOTROPIC GLUTAMATE RECEPTORS -: NMDA receptors are a sub-type of ionotropic glutamate receptor which are selectively activated by the agonist N-Methyl-D-aspartic acid (NMDA). The heterotetrameric complex binds glutamate, allowing the passage of Ca²⁺ ions through the channel. They are best characterized for their roles in excitatory synaptic transmission in the CNS. (Adapted from FBrf0218524 and FBrf0233872).

Protein Function (UniProtKB)

(UniProt, Q24418)

Summary (Interactive Fly)

voltage/Mg2+-dependent Ca2+ channels activated by glutamate - required for olfactory learning

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nmdar1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24418)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nmdar1-RA

FBtr0078763

NM_169059

4170

997

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nmdar1-PA

FBpp0078410

112.3

997

8.07

Q24418

NP_730940

AAF52016

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

Staining pattern of Nmdar1 is determined using an antisera raised against the mammalian ionotropic NMDA1 receptor. Authors suggest lack of appreciable staining pattern in the optic lobes may reflect species differences. sr101111

(Kolodziejczyk et al., 2008)

External Data

Subunit Structure (UniProtKB)

Forms a heteromeric NMDA channel with Nmdar2.

(UniProt, Q24418)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q24418

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nmdar1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nmdar1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval lateral VNC glial cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

larval midline neuron

(Kearney et al., 2004)

embryonic stage 16

larval central nervous system | ubiquitous

(Volkner et al., 2000)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage A1 -- day 10 of adulthood

pedunculus of adult mushroom body

(Sinakevitch et al., 2010)

adult mushroom body alpha-lobe

(Sinakevitch et al., 2010)

adult mushroom body beta-lobe

(Sinakevitch et al., 2010)

adult mushroom body gamma-lobe

(Sinakevitch et al., 2010)

day 10 of adulthood

Kenyon cell | subset

(Sinakevitch et al., 2010)

calyx of adult mushroom body | faint

(Sinakevitch et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Nmdar1 protein is expressed throughout the adult brain but more strongly in some cells. Staining is punctate which suggests synaptic localisation. Cells more strongly stained include several pairs of dorsal posterior medial (DPM2, 3 pairs of DPM3, 4 pairs of DPM4 and DPM5) neurons that surround the mushroom body calyx, in the dorsal anterior lateral neuron of the protocerebrum (DAL), in the dorsal posterior lateral (DPL) neurons in the lateral protocerebrum, the ventral anterior lateral (VAL) neurons in the anterior protocerebrum and two pairs of ventral posterior neurons in the posterior protocerebrum. There is restricted expression in the optic lobe.

(Xia et al., 2005)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of ionotropic glutamate receptor complex

inferred from physical interaction with FLYBASE:Nmdar2; FB:FBgn0053513

(Xia et al., 2005)

located_in membrane

inferred from direct assay

(Xia et al., 2005)

part_of NMDA selective glutamate receptor complex

inferred from direct assay

(Xia et al., 2005)

located_in postsynaptic membrane

inferred from direct assay

(Xia et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nmdar1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nmdar1

View exonic expression by tissue for Dmel\Nmdar1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010399

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40665/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010399

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010399

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010399

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2902

Flygut - An atlas of the Drosophila adult midgut

FBgn0010399

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Nmdar1

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nmdar1

Transgenic constructs containing regulatory region of Nmdar1

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)90B.0

(Maiya et al., 2012)

Df(3R)Exel6144

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die | recessive

Nmdar1^F

viable

Nmdar1^{MI11796-GFSTF.0}

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Nmdar1^GD2808

viable, with Scer\GAL4^Mef2.PR

Nmdar1^GD2808

viable, with Scer\GAL4^pnr-MD237

Nmdar1^GD2808

viable, with Scer\GAL4^tin.CΔ4

Nmdar1^GD2808

viable | recessive

Other Phenotypes

Allele

abnormal learning

abnormal learning | heat sensitive, with Scer\GAL4^P26.hs

Nmdar1^EP331

abnormal learning | recessive

abnormal long-term memory, with Scer\GAL4^nSyb.PS

Nmdar1^JF01961

abnormal mating | dominant

Nmdar1^F

abnormal memory

abnormal memory, with Scer\GAL4^C42

Nmdar1^N631Q.UAS

abnormal memory, with Scer\GAL4^c309

Nmdar1^N631Q.UAS

abnormal memory, with Scer\GAL4^elav.PU

Nmdar1^N631Q.UAS

abnormal memory, with Scer\GAL4^ey-OK107

abnormal memory, with Scer\GAL4^Feb170

abnormal memory | adult stage, with Hsap\RELA^AD.R58E02, Scer\GAL4^DBD.R37E10

Nmdar1^HMS02200

abnormal memory | heat sensitive, with Scer\GAL4^hs.PU

Nmdar1^RNAi.UAS.cWa

abnormal memory | heat sensitive, with Scer\GAL4^P26.hs

Nmdar1^EP331

abnormal memory | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Nmdar1^N631Q.UAS

abnormal neuroanatomy | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar1^GD2808

abnormal phototaxis, with Scer\GAL4^elav-C155

Nmdar1^UAS.Exel

abnormal phototaxis, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B

Nmdar1^UAS.Exel

abnormal phototaxis | heat sensitive, with Scer\GAL4^hs.PB

abnormal touch response, with Scer\GAL4^109(2)80

Nmdar1^KK107519

abnormal touch response, with Scer\GAL4^1003.3

Nmdar1^KK107519

abnormal touch response | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar1^GD2808

chemical sensitive | adult stage

decreased sleep

Nmdar1^KO-Gal4

Phenotype manifest in

Allele

larval dorsal multidendritic neuron ddaA | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar1^GD2808

sensory dendrite | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

Nmdar1^GD2808

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\GRIN1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (26)

Rnor\Grin1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (26)

Mmus\Grin1

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (24)

Xtro\grin1

7 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (46)

Drer\grin1b

13 of 14

Yes

Drer\grin1a

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch211-251b21.1

2 of 14

Drer\si:dkey-183j2.10

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (33)

Cele\nmr-1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (52)

Agam\AgaP_AGAP001478

11 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR5

7 of 13

Yes

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nmdar1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (52)

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

EHR

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mtt

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

alcohol, response to, NMDA-receptor-mediated

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Nmdar1^EP331

model of Kohlschutter-Tonz syndrome

CEA with Indy³⁰²

(Jeong et al., 2021)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

GRIN1; glutamate ionotropic receptor NMDA type subunit 1

model of developmental and epileptic encephalopathy 101

IEA

(FlyBase, 2019-)

model of autosomal dominant intellectual developmental disorder 8

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Nmdar1^EP331

ameliorates neurodegenerative disease

modeled by mir-1000^KO1, mir-1000^KO2

(Verma et al., 2015)

Nmdar1^UAS.cMa

ameliorates Renpenning syndrome

modeled by PQBP1^PL00109

(Tamura et al., 2010)

Nmdar1^KK107519

ameliorates neurodegenerative disease

modeled by mir-bft^Δ263a-G4, mir-bft²⁴

(Aw et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIN1; glutamate ionotropic receptor NMDA type subunit 1

13 of 14

138249

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Nmdar1 - dlg1

anti bait coimmunoprecipitation, western blot

(Maiya et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Nmdar1

enhanceable

Adcy1

(Qin and Dubnau, 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Adcy1

enhanceable

Nmdar1

(Qin and Dubnau, 2010)

mir-1000

suppressible

Nmdar1

(Verma et al., 2015)

PQBP1

suppressible

Nmdar1

(Tamura et al., 2013, Tamura et al., 2010)

TrpA1

enhanceable

Nmdar1

(Sudhakaran et al., 2012)

External Data

Subunit Structure (UniProtKB)

Forms a heteromeric NMDA channel with Nmdar2.

(UniProt, Q24418 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010399

MIST (genetic) - An integrated Molecular Interaction Database

40665

MIST (protein-protein) - An integrated Molecular Interaction Database

40665

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83A6-83A7

Sequence location

3R:5,508,842..5,523,328 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83A6-83A7

Limits computationally determined from genome sequence between P{PZ}Snr1⁰¹³¹⁹&P{PZ}Itp-r83A⁰⁵⁶¹⁶ and P{lacW}Atu^s1938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

83A-83B

(Schmitt, 1993.5.5)

83A-83B

(determined by in situ hybridisation)

(Ultsch et al., 1993)

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (46)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

73085

w¹¹¹⁸; P{VT036874-p65.AD}attP40

73104

w¹¹¹⁸; P{VT036871-p65.AD}attP40

Korea

13163

P{VT036876-GAL4}attP2

15181

P{VT036874-GAL4}attP2

14490

P{VT036875-lexA::p65}attP2

17387

P{VT036876-lexA::GADfl}attP2

VDRC

v104773

P{KK107519}VIE-260B

v201583

P{VT036871-GAL4}attP2

v203402

P{VT036875-GAL4}attP2

v37333

w¹¹¹⁸; P{GD2808}v37333

v37334

w¹¹¹⁸; P{GD2808}v37334

v318672

PBac{fTRG00810.sfGFP-TVPTBF}VK00002

More stocks available...

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE12105

Other clones

DPiM_RE12105

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010399

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010399

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Xia et al., 2005)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Nmdar1 cDNA is isolated and sequence analysis displays a high sequence identity to the vertebrate NMDAR1 receptor subunit. Nmdar1 transcripts are abundant in adult heads.

(Ultsch et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Nmdar CG2902

(Zheng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (28)

Reported As

Symbol Synonym

CG2902

(Mao et al., 2024, Kondo et al., 2020, Dai et al., 2019, Hu et al., 2015, Tsubouchi et al., 2012, Croset et al., 2010, Ni et al., 2010.12.1, Benton et al., 2009, Keleman et al., 2009.8.5, Lee et al., 2009, Perkins et al., 2009.1.15, Venkiteswaran and Hasan, 2009, Mount, 2001.8.14)

DMNMDAR1

(Wismar et al., 1997)

DNMDAR-I

(Schmitt et al., 1993, Ultsch et al., 1993)

DNmdar

DmelNmdar1

(Croset et al., 2010)

DrNR1

(Fu et al., 2001)

NMDA

(Bai and Suzuki, 2020, Busto et al., 2017, Draper et al., 2008)

NMDA R1

(Draper et al., 2008)

NMDA-R1

(Bertin et al., 2022, Tio et al., 2016)

NMDAR

(Cai et al., 2025, Larnerd et al., 2024, Dvořáček and Kodrík, 2021, Ishimoto and Kamikouchi, 2021, Paraskevopoulos and McGuigan, 2021, Muralidharan, 2020, Ly et al., 2018, Koenig et al., 2015)

NMDAR1

(Zheng et al., 2025, Barber et al., 2021, Jafari and Alenius, 2021, Li et al., 2021, Guo et al., 2020, Dai et al., 2019, Golovin et al., 2019, Troutwine et al., 2019, Qu et al., 2018, Maiya et al., 2012, Zhou et al., 2010, Venkiteswaran and Hasan, 2009, Kolodziejczyk et al., 2008)

NMdar1

(Hoopfer et al., 2008)

NR1

(Jayakumar et al., 2016, Liu et al., 2016, Pai et al., 2013, Tamura et al., 2013, Maiya et al., 2012, French and Heberlein, 2009, Xia and Chiang, 2009, Zachepilo et al., 2008)

NRI

(Littleton and Ganetzky, 2000)

NmdaR1

(Grotewiel and Bettinger, 2015)

Nmdar

(Mensch et al., 2008)

Nmdar1

(Bhandari et al., 2024, Chvilicek et al., 2024, Qiao et al., 2022, Golovin et al., 2021, Park et al., 2021, Scaplen and Petruccelli, 2021, Xie et al., 2021, Chvilicek et al., 2020, Kondo et al., 2020, Lathen et al., 2020, Mazzotta et al., 2020, Zhang and Zhang, 2020, Huang et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Aw et al., 2017, Lin et al., 2017, Park et al., 2017, Transgenic RNAi Project members, 2017-, Ueno et al., 2017, Crocker et al., 2016, Sarov et al., 2016, Schwartz et al., 2016, Gene Disruption Project members, 2015-, Hu et al., 2015, Omelyanchuk et al., 2015, Tomita et al., 2015, Verma et al., 2015, Zhang et al., 2014, Robinson and Atkinson, 2013, Maiya et al., 2012, Rodriguez et al., 2012, Tsubouchi et al., 2012, Tsubouchi et al., 2012, Carreira et al., 2011, Croset et al., 2010, Singh et al., 2010, Benton et al., 2009, Mensch et al., 2008, Wu et al., 2007)

dnmdar-I

(Volkner et al., 2000)

dsNR1

(Paranjpe et al., 2012)

nmdar1

(Dai et al., 2019)

nmr

(Schmitt, 1993.5.5)

nr1

(Rosenthal and Yuan, 2021, Naganos et al., 2016)

Name Synonyms

N-methyl-D-aspartate

(Cai et al., 2025)

NMDA receptor

(Dubnau et al., 2003, Rothenfluh and Heberlein, 2002)

NMDA receptor 1

(Shafer, 2025, Tsubouchi et al., 2012, Sambandan et al., 2006)

NMDA receptor I

(Fu et al., 2001)

NMDAR

(Maiya et al., 2012, Dubnau et al., 2003)

Nmdar1

(Tomita et al., 2017)

dNR1

(Xia et al., 2005)

receptor

(Cai et al., 2025)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40665

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24418

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24418

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24418

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010399

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40665/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010399

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010399

FlyMine - An integrated database for Drosophila genomics

FBgn0010399

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2902

MARRVEL_MODEL - MARRVEL (model organism gene)

40665

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010399

DroID - A comprehensive database of gene and protein interactions.

FBgn0010399

DRSC - Results frm RNAi screens

FBgn0010399

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nmdar1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010399

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010399

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2902

Flygut - An atlas of the Drosophila adult midgut

FBgn0010399

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010399

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

MIST (genetic) - An integrated Molecular Interaction Database

40665

MIST (protein-protein) - An integrated Molecular Interaction Database

40665

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (179)

The following external sites may use different assemblies or annotations than FlyBase.

-0.69

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