Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dock using the Feature Mapper tool.
dock transcripts are detected in the brain and ventral nerve cord of stage 14 embryos. Ptp61F and dock transcripts are expressed in a similar pattern throughout development, with high levels in embryonic, pupal and adult stages.
GBrowse - Visual display of RNA-Seq signalsView Dmel\dock in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
dock facilitates synapse formation by the RP3 motoneuron and is required for guidance of some interneuronal axons. dock mediated signalling may be important in remodelling the RP3 growth cone's cytoskelton.
Loss of zygotic dock function causes a selective delay in synapse formation by the RP3 motoneuron at the cleft between muscles 7 and 6. In late stage 16 mutant embryos these muscles often lack innervation. By the third larval instar muscles have become innervated by RP3. dock mutants also show subtle defects in the CNS longitudinal axon pathway.
Isolated in a yeast two-hybrid system, by screening for Ptp61F-interacting proteins.
The gene is named "dreadlocks" for the appearance of the receptor cell projection pattern in the mutant.