PTB, polypyrimidine tract-binding protein, l(3)03429, dmPTB, Polypyrimidine Tract Binding protein
polypyrimidine tract binding protein - controls alternative splicing - required to attenuate Notch activity after ligand-dependent activation during wing development - functions in male germline
Please see the JBrowse view of Dmel\heph for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\heph using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: extended 3' UTR isoform
Zygotic-specific isoforms of heph with long 3' UTR extensions were observed.
heph is predominantly expressed in the nuclei of primary spermatocytes in males
heph accumulates in the cytoplasm in the germrium. It accumulates transiently in the center of the oocytes in stages S7,8 and is localized to the posterior pole of the oocyted from stage S9 onward suggesting that it is transported with Oskar mRNA to the pole. heph is expressed both in the germline and in the somatic epithelium.
Comment: subset of neuronal cell bodies in the adult brain cortex
JBrowse - Visual display of RNA-Seq signals
View Dmel\heph in JBrowse
3-103
3-99.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: PTB CG2094
Source for merge of: heph ema
Source for merge of: heph PTB
Source for merge of: PTB CG2290
Annotations CG2094, CG2290 merged as CG31000 in release 3 of the genome annotation.
Source for merge of heph PTB was sequence comparison ( date:011101 ).
Source for identity of: ema l(3)03429
