lb, ladybird
transcription factors - homeodomain proteins -overlaps expression of wingless in the epidermis - ladybird genes contribute to the segmentation process and are considered as segment polarity genes
Please see the JBrowse view of Dmel\lbe for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
479 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lbe using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
lbe transcript appears earlier, and is more abundant, than the lbl transcript. lbe transcript first appears at stage 8 of embryogenesis, in the anal plate primordium, and subsequently in stage 10-11, in some neuroblasts and in the ectoderm of gnathal segments. At stage 10-11, expression is also detected in a cluster of cells corresponding to the heart primordium. During stage 10-13, lbe and lbl are both expressed in the dorsal ectoderm of abdominal segments 1-7, and to a lesser extent, in the ventral ectoderm. At stage 15, lbl and FBgn0011278:lbe transcripts persist in the dorsal, but not in the ventral epidermis. Later in embryogenesis, FBgn0008651:lbl and FBgn0011278:lbe @ transcripts are restricted to clusters of cells in the central and peripheral nervous systems, and to the segment border muscles.
Using RT-PCR, lbe transcript is detected early in embryogenesis, about 2 hours before lbl, and persists through embryogenesis. Using in-situ hybridization, lbe transcript is detected in stage 11 embryos, in the dorsal and ventral epidermis in a segmentally repeated pattern. lbl and lbe are expressed in cells just anterior to those expressing en.
Comment: tip of the frontal sac
Comment: presumptive
Comment: presumptive
abdominal lateral adult muscle precursor cell ; FBbt:00003243
lbe is dynamically expressed in myoblasts associated with the leg imaginal disc proper. All leg myoblasts express twi. lbe is expressed initially in early third instar larvae in a small subset of twi-expressing cells located in the dorsal femur and giving rise to the levator muscle. Most ventrally, lbe marks individual myoblasts that give rise to the tibial depressor muscle. The number of leg myoblasts expressing lbe gradually increases, and at the beginning of pupation, all of them express lbe at least at a low level. Myoblasts associated with the proximal portion of the leg disc are lbe-negative. 3D analysis reveals that lbe myoblasts form spatially restricted groups of cells lying at highly stereotyped positions that can be correlated with defined muscles in the adult leg. In the tibia and femur at 0hr APF, the groups of lbe-expressing myblasts are located dorsally and ventrally at positions representing the levator and the depressor muscles. They are also seen at muscle-forming sites for the trochanter and coxa. lbe is also expressed in leg disc epithelium in the ventral region and in the long tendon.
lbe is expressed in the two central cardioblasts of every hemisegment.
Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d4; deuterocerebrum - d7; protocerebrum - cv8, pv3
lbe gene product appears earlier, and is more abundant, than the lbl gene product. lbe protein first appears at stage 8 of embryogenesis, in the anal plate primordium, and subsequently in stage 10-11, in some neuroblasts and in the ectoderm of gnathal segments. At stage 10-11, expression is also detected in a cluster of cells corresponding to the heart primordium. During stage 10-13, lbe and lbl are both expressed in the dorsal ectoderm of abdominal segments 1-7, and to a lesser extent, in the ventral ectoderm. At stage 15, lb and lbe gene products persist in the dorsal, but not in the ventral epidermis. Later in embryogenesis, lbl and lbe gene products are restricted to clusters of cells in the central and peripheral nervous systems, and to the segment border muscles.
JBrowse - Visual display of RNA-Seq signals
View Dmel\lbe in JBrowse3-72
3-74.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
dsRNA has been made from templates generated with primers directed against this gene. RNAi of lbe results in increased arborization of ddaD and ddaE neurons. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
The specific epidermal expression patterns of lbe and lbl and their regulatory interactions with wg are analysed. Activity of lbe and lbl in the epidermis is regulated by the segment polarity gene network and depends on wg signalling. lbe and lbl are required in the dorsal epidermis and for anal plate development.
Source for merge of: lbe Hox11-D125
Source for merge of lbe Hox11-D125 was sequence comparison ( date:030604 ).
