FB2021_06, released December 14, 2021

Gene: Dmel\Dop1R1

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General Information
Symbol
Dmel\Dop1R1
Species
D. melanogaster
Name
Dopamine 1-like receptor 1
Annotation Symbol
CG9652
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011582
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis. (UniProt, P41596)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DopR, DopR1, dumb, dDA1, dopamine receptor

Key Links
Genomic Location
Cytogenetic map
88A10-88A12
Sequence location
Recombination map
3-54
RefSeq locus
NT_033777 REGION:14165379..14214810
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (25 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables dopamine neurotransmitter receptor activity, coupled via Gs
inferred from mutant phenotype
(assigned by UniProt )
(Sugamori et al., 1995)
inferred from direct assay
(Gotzes et al., 1994)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables dopamine neurotransmitter receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
enables G protein-coupled receptor activity
inferred from sequence or structural similarity
(Radford et al., 2002)
enables G protein-coupled serotonin receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(assigned by GO_Central )
(Gaudet et al., 2011)
enables neurotransmitter receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (17 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating dopamine receptor signaling pathway
inferred from direct assay
(Gotzes et al., 1994)
involved_in associative learning
inferred from mutant phenotype
(assigned by UniProt )
(Seugnet et al., 2008, Kim et al., 2007)
involved_in cellular response to sucrose stimulus
inferred from direct assay
(Inagaki et al., 2012)
involved_in learning
inferred from mutant phenotype
(Keleman et al., 2012)
involved_in memory
inferred from mutant phenotype
(assigned by UniProt )
(Seugnet et al., 2008, Kim et al., 2007)
involved_in olfactory learning
inferred from mutant phenotype
(Selcho et al., 2009)
involved_in regulation of olfactory learning
inferred from mutant phenotype
(Liu et al., 2009)
involved_in regulation of presynaptic cytosolic calcium ion concentration
inferred from mutant phenotype
(Cohn et al., 2015)
involved_in response to odorant
inferred from mutant phenotype
(Cohn et al., 2015)
involved_in response to starvation
inferred from mutant phenotype
(Inagaki et al., 2012)
involved_in response to sucrose
inferred from mutant phenotype
(Inagaki et al., 2012)
involved_in thermosensory behavior
inferred from mutant phenotype
(Bang et al., 2011)
involved_in thermotaxis
inferred from mutant phenotype
(Bang et al., 2011)
involved_in visual learning
inferred from mutant phenotype
(assigned by UniProt )
(Gotzes et al., 1994)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in chemical synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in dopamine receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in dendrite
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000664111
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of plasma membrane
inferred from sequence model
(Gotzes et al., 1994)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 1 family. (P41596)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
DOPAMINE RECEPTORS -
Dopamine GPCRs are Class A GPCRs. Dopamine is a neurotransmitter involved in a variety of behavioural and physiological functions such as memory, arousal and mating behaviour. (Adapted from PMID:17088868 and FBrf0219823).
Protein Function (UniProtKB)
Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.
(UniProt, P41596)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Dop1R1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Double stop-codon suppression (UGA, UGA) postulated; FBrf0216884.

Transposon inserted in intron

Gene model reviewed during 5.44

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dop1R1-RB
FBtr0290283
NM_057659
2661
496
Dop1R1-RC
FBtr0301351
NM_001170136
2616
481
Dop1R1-RD
FBtr0308191
NM_001260163
14565
511
Dop1R1-RE
FBtr0330711
NM_001275634
2661
560
Dop1R1-RF
FBtr0346763
NM_001316525
2661
535
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dop1R1-PB
FBpp0288722
54.4
496
8.37
NP_477007
AAF55030
Dop1R1-PC
FBpp0290565
52.9
481
8.65
NP_001163607
ACZ94904
Dop1R1-PD
FBpp0300511
56.2
511
8.37
NP_001247092
AFH06410
Dop1R1-PE
FBpp0303554
60.9
560
7.33
NP_001262563
AGB95944
Dop1R1-PF
FBpp0312358
58.4
535
8.04
NP_001303454
ALI30568
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop1R1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data

DopR transcripts appear to be maternally inherited and are abundant in syncytial stages. At these and cellular stages, transcripts are restricted to apical regions of the cortical, peripheral cytoplasm. Later, DopR transcripts are specifically associated with the extending germ band and are excluded from the invaginating posterior mesoderm and the presumptive head regions. DopR transcripts are uniformly distributed in all developing tissues in later stages of embryogenesis.

(Sugamori et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
Tvb neuron
(Baumgardt et al., 2007)
adult stage
adult ellipsoid body ring neuron R4d | restricted
(Kahsai et al., 2012)
adult ellipsoid body ring neuron R3 | restricted
(Kahsai et al., 2012)
ellipsoid body outer central domain | restricted
(Kahsai et al., 2012)
fan-shaped body | restricted
(Kahsai et al., 2012)
nodulus
(Kahsai et al., 2012, Kong et al., 2010)
ellipsoid body
(Kong et al., 2010)
fan-shaped body
(Kong et al., 2010)
adult mushroom body
(Kong et al., 2010)
pedunculus of adult mushroom body
(Kong et al., 2010)
adult ventral nerve cord | restricted
(Pitmon et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

DopR protein is detected in the ellipsoid body, in the rings innervated by R3 and R4d ring neurons. In the fan-shaped body, strong expression is observed in the dorsal and ventral layers, with weaker labelling observed in the central layers. In the nodulus, strong expression is observed in layers I and II.

(Kahsai et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GMR72B02-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult mushroom body
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
Reporter: P{GMR72B03-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult pars intercerebralis
(Jiang et al., 2016)
adult median bundle
(Jiang et al., 2016)
adult antennal lobe
(Jiang et al., 2016)
antler
(Jiang et al., 2016)
prow
(Jiang et al., 2016)
Reporter: P{GMR72B08-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
gamma Kenyon cell
(Yamazaki et al., 2018)
adult mushroom body
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
Reporter: P{GMR72B09-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ellipsoid body
(Jiang et al., 2016)
adult lateral horn
(Jiang et al., 2016)
adult gnathal ganglion
(Jiang et al., 2016)
adult mushroom body
(Jiang et al., 2016)
Reporter: P{GMR72B10-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
wedge | faint | restricted
(Jenett and Svirskas, 2012.9.24)
antennal mechanosensory and motor center
(Jiang et al., 2016)
adult lateral horn
(Jiang et al., 2016)
protocerebral bridge
(Jiang et al., 2016)
adult gnathal ganglion
(Jiang et al., 2016)
Reporter: P{GMR72B12-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult mushroom body | intense | restricted
(Jenett and Svirskas, 2012.9.24)
posterior lateral protocerebrum | faint | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body
(Jiang et al., 2016)
adult antennal lobe
(Jiang et al., 2016)
fan-shaped body
(Jiang et al., 2016)
nodulus
(Jiang et al., 2016)
Reporter: P{GMR72C01-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
anterior optic tubercle | faint | restricted
(Jenett and Svirskas, 2012.9.24)
antennal mechanosensory and motor center | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body
(Jiang et al., 2016)
antennal mechanosensory and motor center
(Jiang et al., 2016)
protocerebral bridge
(Jiang et al., 2016)
adult gnathal ganglion
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
fan-shaped body
(Jiang et al., 2016)
Reporter: P{GMR72C02-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
gall | faint | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body | intense | restricted
(Jenett and Svirskas, 2012.9.24)
adult mushroom body
(Jiang et al., 2016)
adult antennal lobe
(Jiang et al., 2016)
adult lateral horn
(Jiang et al., 2016)
adult optic lobe
(Jiang et al., 2016)
Reporter: PBac{GAL4D,EYFP}Dop1R1PL00420
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ellipsoid body
(Bai and Sehgal, 2015, Kong et al., 2010)
adult central complex
(Kong et al., 2010)
nodulus
(Kong et al., 2010)
fan-shaped body
(Bai and Sehgal, 2015, Kong et al., 2010)
adult mushroom body
(Kong et al., 2010)
pedunculus of adult mushroom body
(Kong et al., 2010)
adult antennal lobe glomerulus | subset
(Kong et al., 2010)
adult protocerebrum | restricted
(Kong et al., 2010)
adult ellipsoid body R-neuron
(Kong et al., 2010)
adult mushroom body | faint
(Bai and Sehgal, 2015)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dop1R1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dop1R1
Transgenic constructs containing regulatory region of Dop1R1
Aberrations (Deficiencies and Duplications) ( 3 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4elav.PLu
lethal | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Scer\GAL4Mef2.PR
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal chemosensitive behavior | dominant | larval stage
abnormal chemosensitive behavior | larval stage, with Scer\GAL4NPF.1
abnormal courtship behavior | male
abnormal courtship behavior | male, with Scer\GAL41471
abnormal courtship behavior | male, with Scer\GAL4Tab2-201Y
abnormal feeding behavior | dominant | larval stage
abnormal feeding behavior | larval stage, with Scer\GAL4NPF.1
abnormal flight, with Scer\GAL4elav.PLu
abnormal flight, with Scer\GAL4Mef2.PR
abnormal learning
abnormal learning, with Scer\GAL4c747
abnormal learning (with In(3LR)234)
abnormal learning | male
abnormal learning | male, with Scer\GAL41471
abnormal learning | male, with Scer\GAL4Tab2-201Y
abnormal learning | recessive
abnormal locomotor behavior | adult stage, with Scer\GAL4Clk.-856
abnormal locomotor behavior | RU486 conditional, with Scer\GAL4Pdf.Switch1a
abnormal memory
abnormal memory, with Dop1R1f02676, Scer\GAL4ey-OK107
abnormal memory, with Dop1R1UAS.cKa, Scer\GAL4ey-OK107
abnormal memory | adult stage
abnormal memory | adult stage, with Hsap\RELAAD.R13F02, Scer\GAL4DBD.R44E04
abnormal memory | adult stage, with Scer\GAL4c739
abnormal memory | adult stage, with Scer\GAL4nSyb.PS
abnormal neurophysiology
abnormal sleep | adult stage
abnormal smell perception
abnormal thermotaxis | adult stage
abnormal thermotaxis | adult stage (with Df(3R)red-P52)
decreased sleep, with Scer\GAL4Pdf.PU
decreased sleep | RU486 conditional, with Scer\GAL4Pdf.Switch1a
hyperactive | chemical conditional
hypoactive | adult stage
hypoactive | chemical conditional
hypoactive | chemical conditional (with Df(3R)ED5634)
some die during immature adult stage | recessive, with Scer\GAL4elav.PLu
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DRD5
9 of 15
Yes
Yes
Hsap\DRD1
6 of 15
No
Yes
Hsap\ADRA1A
1 of 15
No
No
Hsap\ADRB1
1 of 15
No
No
Hsap\ADRB2
1 of 15
No
No
2  
Hsap\ADRB3
1 of 15
No
No
Hsap\FLT1
1 of 15
No
No
Hsap\HRH2
1 of 15
No
No
1  
Hsap\HTR4
1 of 15
No
No
Hsap\HTR6
1 of 15
No
Yes
Hsap\OR5T2
1 of 15
No
Yes
Hsap\OR5T3
1 of 15
No
Yes
Hsap\OR6T1
1 of 15
No
Yes
Hsap\OR10H1
1 of 15
No
Yes
Hsap\OR10H2
1 of 15
No
Yes
Hsap\OR10H3
1 of 15
No
Yes
Hsap\OR10H4
1 of 15
No
Yes
Hsap\OR10H5
1 of 15
No
Yes
Hsap\OR10J5
1 of 15
No
Yes
Hsap\OR10J6P
1 of 15
No
Yes
Hsap\OR11H4
1 of 15
No
Yes
Hsap\OR11H7
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Drd1
7 of 15
Yes
Yes
Mmus\Drd5
7 of 15
Yes
Yes
Mmus\Adra1a
1 of 15
No
No
Mmus\Adrb1
1 of 15
No
No
Mmus\Adrb2
1 of 15
No
No
Mmus\Adrb3
1 of 15
No
No
Mmus\Hrh2
1 of 15
No
No
Mmus\Htr4
1 of 15
No
No
Mmus\Htr6
1 of 15
No
Yes
Mmus\Olfr16
1 of 15
No
Yes
Mmus\Olfr55
1 of 15
No
Yes
Mmus\Olfr63
1 of 15
No
Yes
Mmus\Olfr239
1 of 15
No
Yes
Mmus\Olfr472
1 of 15
No
Yes
Mmus\Olfr473
1 of 15
No
Yes
Mmus\Olfr474
1 of 15
No
Yes
Mmus\Olfr479
1 of 15
No
Yes
Mmus\Olfr509
1 of 15
No
Yes
Mmus\Olfr746
1 of 15
No
Yes
Mmus\Olfr747
1 of 15
No
Yes
Mmus\Olfr748
1 of 15
No
Yes
Mmus\Olfr749
1 of 15
No
Yes
Mmus\Olfr1093
1 of 15
No
Yes
Mmus\Olfr1094
1 of 15
No
Yes
Mmus\Olfr1102
1 of 15
No
Yes
Mmus\Olfr1564
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (26)
Rnor\Drd1
7 of 13
Yes
Yes
Rnor\Drd5
7 of 13
Yes
Yes
Rnor\Htr6
2 of 13
No
Yes
Rnor\Adrb1
1 of 13
No
No
Rnor\Adrb2
1 of 13
No
No
Rnor\Adrb3
1 of 13
No
No
Rnor\Hrh2
1 of 13
No
Yes
Rnor\Htr4
1 of 13
No
No
Rnor\LOC100909683
1 of 13
No
Yes
Rnor\Olr240
1 of 13
No
Yes
Rnor\Olr241
1 of 13
No
Yes
Rnor\Olr245
1 of 13
No
Yes
Rnor\Olr515
1 of 13
No
Yes
Rnor\Olr517
1 of 13
No
Yes
Rnor\Olr518
1 of 13
No
Yes
Rnor\Olr519
1 of 13
No
Yes
Rnor\Olr1091
1 of 13
No
Yes
Rnor\Olr1093
1 of 13
No
Yes
Rnor\Olr1095
1 of 13
No
Yes
Rnor\Olr1576
1 of 13
No
Yes
Rnor\Olr1622
1 of 13
No
Yes
Rnor\Olr1631
1 of 13
No
Yes
Rnor\Olr1632
1 of 13
No
Yes
Rnor\Olr1635
1 of 13
No
Yes
Rnor\Olr1875
1 of 13
No
Yes
Rnor\Taar7h
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\drd1c
8 of 12
Yes
Yes
Xtro\drd1
7 of 12
No
Yes
Xtro\drd5
3 of 12
No
Yes
Xtro\adrb1
1 of 12
No
No
Xtro\adrb2
1 of 12
No
No
Xtro\htr6
1 of 12
No
Yes
Xtro\LOC100490372
1 of 12
No
No
Danio rerio (Zebrafish) (32)
Drer\drd6b
8 of 15
Yes
Yes
Drer\drd1a
7 of 15
No
Yes
Drer\drd1b
7 of 15
No
Yes
Drer\drd7
7 of 15
No
Yes
Drer\LOC563567
4 of 15
No
Yes
Drer\LOC567498
4 of 15
No
Yes
Drer\hrh2b
2 of 15
No
Yes
Drer\taar12m
2 of 15
No
Yes
Drer\adrb1
1 of 15
No
No
Drer\adrb2a
1 of 15
No
No
Drer\adrb2b
1 of 15
No
No
Drer\adrb3a
1 of 15
No
No
Drer\adrb3b
1 of 15
No
No
Drer\drd5a
1 of 15
No
Yes
Drer\htr4
1 of 15
No
No
Drer\htr6
1 of 15
No
Yes
Drer\si:dkey-247m21.3
1 of 15
No
No
Drer\taar10
1 of 15
No
Yes
Drer\taar12a
1 of 15
No
No
Drer\taar12b
1 of 15
No
No
Drer\taar12c
1 of 15
No
No
Drer\taar12e
1 of 15
No
No
Drer\taar12f
1 of 15
No
No
Drer\taar12g
1 of 15
No
No
Drer\taar12h
1 of 15
No
No
Drer\taar12i
1 of 15
No
No
Drer\taar12j
1 of 15
No
No
Drer\taar14i
1 of 15
No
Yes
Drer\taar19g
1 of 15
No
Yes
Drer\taar19s
1 of 15
No
Yes
Drer\taar20b1
1 of 15
No
Yes
Drer\taar20j
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\dop-1
9 of 15
Yes
Yes
Cele\ser-5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906ES )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010738
Drosophila simulans
Dsim\GD20445
Drosophila sechellia
Dsec\GM25874
Drosophila erecta
Dere\GG21429
Drosophila yakuba
Dyak\GE10051
Drosophila ananassae
Dana\GF18779
Drosophila pseudoobscura pseudoobscura
Dpse\GA21941
Drosophila persimilis
Dper\GL23301
Drosophila willistoni
Dwil\GK10900
Drosophila virilis
Dvir\GJ22610
Drosophila mojavensis
Dmoj\GI24543
Drosophila grimshawi
Dgri\GH19686
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508L5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017402
Glossina morsitans
Tsetse fly
Gmor\GMOY002017
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13459
Mayetiola destructor
Hessian fly
Mdes\Mdes009052
Anopheles darlingi
American malaria mosquito
Adar\ADAC007810
Anopheles gambiae
Malaria mosquito
Agam\GPRDOP1
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000647
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0JYM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002277
Bombyx mori
Silkmoth
Bmor\BGIBMGA002275
Bombyx mori
Silkmoth
Bmor\BGIBMGA002276
Danaus plexippus
Monarch butterfly
Dple\DPOGS202585-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003917
Apis florea
Little honeybee
Aflo\2379349252
Apis florea
Little honeybee
Aflo\2161031906
Apis mellifera
Western honey bee
Amel\GB50192
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14827
Bombus terrestris
Buff-tailed bumblebee
Bter\15205619
Linepithema humile
Argentine ant
Lhum\LH18257
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002cdf
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001652
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04374
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04375
Tribolium castaneum
Red flour beetle
Tcas\TC012447
Pediculus humanus
Human body louse
Phum\PHUM434420
Rhodnius prolixus
Kissing bug
Rpro\RPRC014093
Cimex lectularius
Bed bug
Clec\CLEC002966
Cimex lectularius
Bed bug
Clec\CLEC002967
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006935
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10284
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0923 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012831
Ixodes scapularis
Black-legged tick
Isca\ISCW001496
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63867.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05500
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_23898
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06VI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1b_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1aL_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht1F
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adra1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh2_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009149gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-5ht2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MachrM3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Drd1_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hrh2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Htr1aL_4
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018919
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019975
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020513
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004433
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013284
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004781
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003264
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024198
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008896
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002943
Ciona intestinalis
Vase tunicate
Cint\LOC100176265
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000014975
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015953
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026029
Gallus gallus
Domestic chicken
Ggal\HTR1A
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023521
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008949
Gallus gallus
Domestic chicken
Ggal\HTR1D
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009640
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000024171
Gallus gallus
Domestic chicken
Ggal\HTR2A
Gallus gallus
Domestic chicken
Ggal\HTR1F
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000469
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003050
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007794
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000019018
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006362
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004066
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006540
Gallus gallus
Domestic chicken
Ggal\HTR2C
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003270
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015117
Gallus gallus
Domestic chicken
Ggal\HTR1E
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001416
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010778
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001383
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005085
Gallus gallus
Domestic chicken
Ggal\HTR1B
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004930
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013994
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013995
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012040
Gallus gallus
Domestic chicken
Ggal\Gga.320
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008365
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012894
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026998
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015608
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016013
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (19)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
5-HT2B
2 of 10
mAChR-A
2 of 10
mAChR-B
2 of 10
Oamb
2 of 10
Octβ1R
2 of 10
Octβ3R
2 of 10
5-HT1A
1 of 10
5-HT1B
1 of 10
5-HT2A
1 of 10
5-HT7
1 of 10
CG13579
1 of 10
Dop1R2
1 of 10
Dop2R
1 of 10
DopEcR
1 of 10
mAChR-C
1 of 10
Octβ2R
1 of 10
Oct-TyrR
1 of 10
TyrRII
1 of 10
TyrR
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
DRD5; dopamine receptor D5
model of  attention deficit hyperactivity disorder
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
DRD5; dopamine receptor D5
9 of 15
126453
DRD1; dopamine receptor D1
6 of 15
126449
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      RNA-RNA
      Physical Interaction
      Assay
      References
      Dop1R1 - mir-276a
      quantitative reverse transcription pcr, luminiscence technology
      (Zhang et al., 2021, Li et al., 2013)
      Dop1R1 - mir-276b
      luminiscence technology
      (Zhang et al., 2021)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Dop1R1
      enhanceable
      Dop1R2
      (Fernandez-Chiappe et al., 2020)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Dop1R2
      enhanceable
      Dop1R1
      (Fernandez-Chiappe et al., 2020)
      DopEcR
      suppressible
      Dop1R1
      (Petruccelli et al., 2016)
      mir-276a
      suppressible
      Dop1R1
      (Li et al., 2013)
      TrpA1
      suppressible
      Dop1R1
      (Sun et al., 2018, Liu et al., 2012, Liu et al., 2012)
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-54
      Cytogenetic map
      88A10-88A12
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      88A10-88A12
      Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      88-89
      (Gibson, 1999.7.26)
      35E-35F
      (determined by in situ hybridisation)
      (Gotzes et al., 1994)
      Experimentally Determined Recombination Data
      Location

      3-54

      (FlyBase, 2016)

      3-52.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (15)
      Genomic Clones (25)
      cDNA Clones (142)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Gruntenko et al., 2012, Kong et al., 2010, Lebestky et al., 2009)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: DopR CG9652

        (Zheng, 1999.11)

        Source for identity of: Dop1R1 DopR

        (FlyBase, 2009-)
        Source for database merge of
        Additional comments

        nAcRα-34E is not DopR.

        (Ashburner et al., 1999.10.12)
        Other Comments

        Certain domains of receptor molecules may vary significantly in different strains of Drosophila but the structural changes do not alter the functional properties of the expressed polypeptides.

        (Gotzes and Baumann, 1996)

        A DopR cDNA has been cloned and sequenced.

        (Sugamori et al., 1995)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 51 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (34)
        Reported As
        Symbol Synonym
        CG9652
        (Ashraf et al., 2020, Kondo et al., 2020, Meadows, 2017.1.11, Yu et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Selcho et al., 2009, Johnson et al., 2008, Ni et al., 2008, Hauser et al., 2006, Srivastava et al., 2005)
        D-Dop1
        (Gotzes et al., 1994)
        D1R1
        (Akiba et al., 2020)
        DA1
        (Dylla et al., 2013, Seugnet et al., 2009, Park et al., 2004)
        DR1
        (Stern et al., 2019, Yang et al., 2015)
        DRD1
        (Jia et al., 2016)
        DmDOP1
        (Qi et al., 2017, Yuan and Lee, 2007)
        DmDop1
        (Kong et al., 2010, Hearn et al., 2002, Gotzes and Baumann, 1996)
        Dmdop1
        (Kehren and Baumann, 2005, Blenau and Baumann, 2001)
        Dop1-R1
        (Ko et al., 2017, Suh et al., 2017)
        Dop1R
        (Kottler et al., 2019)
        Dop1R1
        (Ahn et al., 2021, Evans et al., 2021, McLaughlin et al., 2021, Nässel, 2021, Sareen et al., 2021, Scaplen and Petruccelli, 2021, Siju et al., 2021, Wei et al., 2021, Ashraf et al., 2020, Chakravarti Dilley et al., 2020, Chvilicek et al., 2020, Gao et al., 2020, Honegger et al., 2020, Jakšić et al., 2020, Karam et al., 2020, Kondo et al., 2020, Petruccelli et al., 2020, Scaplen et al., 2020, Brunet Avalos et al., 2019, Deng et al., 2019, Donlea, 2019, Kottler et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Shih et al., 2019, Croset et al., 2018, Landayan et al., 2018, Pu et al., 2018, Pu et al., 2018, Sun et al., 2018, Branco et al., 2017, Ferguson et al., 2017, Park et al., 2017, Tomita et al., 2017, Clandinin and Owens, 2016-, Pimentel et al., 2016, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Morgante et al., 2015, Shankar et al., 2015)
        DopR
        (Highfill et al., 2019, Li et al., 2019, Ly et al., 2018, Ueno et al., 2017, Zajitschek et al., 2017, Crocker et al., 2016, Petruccelli et al., 2016, Pitmon et al., 2016, Zhang et al., 2016, de Taffin et al., 2015, Shih et al., 2015, Tomita et al., 2015, Ashwal-Fluss et al., 2014, Singh et al., 2014, Alekseyenko et al., 2013, Argue and Neckameyer, 2013, Argue and Neckameyer, 2013, Dubnau and Chiang, 2013, Kottler et al., 2013, Li et al., 2013, Perisse et al., 2013, Ueno et al., 2013, Wang et al., 2013, Chen et al., 2012, Gruntenko et al., 2012, Izutsu et al., 2012, Kahsai et al., 2012, Kaun et al., 2012, Liu et al., 2012, Marella et al., 2012, Neckameyer and Bhatt, 2012, Rauschenbach et al., 2012, Bang et al., 2011, Jungreis et al., 2011, Kong et al., 2010, Lebestky et al., 2009, Hoopfer et al., 2008, Johnson et al., 2008, Baumgardt et al., 2007, Baumgardt et al., 2007, Dietzl et al., 2007, Draper et al., 2007, Jones, 2007, Franchini et al., 2004)
        DopR1
        (Dvořáček and Kodrík, 2021, Zhang et al., 2021, Zhang et al., 2021, Ahmad et al., 2020, Kondo et al., 2020, Mazzotta et al., 2020, Nässel and Zandawala, 2020, Texada et al., 2020, Awata et al., 2019, Dag et al., 2019, Handler et al., 2019, Lyutova et al., 2019, Karim et al., 2018, Xie et al., 2018, Lark et al., 2017, Liu et al., 2017, Koenig et al., 2016, Zhang et al., 2016, Cohn et al., 2015, Krüttner et al., 2015, Landayan and Wolf, 2015, Metaxakis et al., 2014, Crickmore and Vosshall, 2013, Perry and Barron, 2013, Inagaki et al., 2012, Keleman et al., 2012, Lebestky et al., 2009)
        DopR35F
        (Feng et al., 1996)
        Dumb
        (Sun et al., 2018, Zhang et al., 2016)
        dDA1
        (Zhao et al., 2019, Medina, 2018, Aranda et al., 2017, Hattori et al., 2017, Himmelreich et al., 2017, Pitmon et al., 2016, Cassar et al., 2015, Davis, 2015, Donlea et al., 2014, Perisse et al., 2013, Perry and Barron, 2013, Seugnet et al., 2011, Kong et al., 2010, Lebestky et al., 2009, Liu et al., 2009, Selcho et al., 2009, Andretic et al., 2008, Seugnet et al., 2008, Kim et al., 2007, Park et al., 2004, Blenau and Baumann, 2001, Sugamori et al., 1995)
        dDA1/DmDOP1
        (Kim et al., 2003)
        dopr
        (Naganos et al., 2016)
        dumb
        (Filošević Vujnović et al., 2021, Melnattur et al., 2021, Kondo et al., 2020, Awata et al., 2019, Kottler et al., 2019, Kim et al., 2017, Koenig et al., 2016, Pitmon et al., 2016, Cassar et al., 2015, Musso et al., 2015, Shih et al., 2015, Donlea et al., 2014, Kottler et al., 2013, Waddell, 2013, Burke et al., 2012, Liu et al., 2012, Van Swinderen and Andretic, 2011, Zars, 2010, Selcho et al., 2009, Seugnet et al., 2009, Andretic et al., 2008, Seugnet et al., 2008, Kim et al., 2007)
        Name Synonyms
        D1 dopamine receptor
        (Dylla et al., 2013, Lebestky et al., 2009)
        D1-Like Dopamine Receptor
        (Kong et al., 2010)
        D1-like DA receptor
        (Kong et al., 2010)
        D1-like receptor
        (Rauschenbach et al., 2011, Gilbert et al., 2000)
        D1 dopamine receptor
        (Neckameyer and Bhatt, 2012)
        DA D1-like receptor
        (Srivastava et al., 2005)
        Dopamine 1-like receptor 1
        Dopamine receptor
        dDA1
        (Dissel et al., 2015)
        dopamine 1 receptor
        (Seugnet et al., 2009)
        dopamine D1 receptor
        (Rothenfluh and Heberlein, 2002)
        dopamine D1-like receptor
        (Seugnet et al., 2008, Niznik, 1995.3.2)
        dopamine receptor
        (Johnson et al., 2008, Jones, 2007, Baumann, 1994.1.21)
        dopaminergic receptor
        (Zhang et al., 2016)
        dumb
        (Pitmon et al., 2016, Faville et al., 2015)
        dumb DA receptor
        (Musso et al., 2015)
        Secondary FlyBase IDs
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (249)