FlyBase Gene Report: Dmel\Dop1R1

General Information

Symbol

Dmel\Dop1R1

Species

D. melanogaster

Name

Dopamine 1-like receptor 1

Annotation Symbol

CG9652

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011582

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DopR, dDA1, dumb, DopR1, DA1

Key Links

Genomic Location

Cytogenetic map

88A10-88A12

Sequence location

3R:14,165,379..14,214,810 [-]

Recombination map

3-54

RefSeq locus

NT_033777 REGION:14165379..14214810

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (25 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables dopamine neurotransmitter receptor activity, coupled via Gs

inferred from direct assay

(Gotzes et al., 1994)

inferred from mutant phenotype

(assigned by UniProt )

(Sugamori et al., 1995)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables dopamine neurotransmitter receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from sequence or structural similarity

(Radford et al., 2002)

enables G protein-coupled serotonin receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(assigned by GO_Central )

(Gaudet et al., 2011)

enables neurotransmitter receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (17 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating dopamine receptor signaling pathway

inferred from direct assay

(Gotzes et al., 1994)

involved_in associative learning

inferred from mutant phenotype

(assigned by UniProt )

(Seugnet et al., 2008, Kim et al., 2007)

involved_in cellular response to sucrose stimulus

inferred from direct assay

(Inagaki et al., 2012)

involved_in learning

inferred from mutant phenotype

(Keleman et al., 2012)

involved_in memory

inferred from mutant phenotype

(assigned by UniProt )

(Seugnet et al., 2008, Kim et al., 2007)

involved_in olfactory learning

inferred from mutant phenotype

(Selcho et al., 2009)

involved_in regulation of olfactory learning

inferred from mutant phenotype

(Liu et al., 2009)

involved_in regulation of presynaptic cytosolic calcium ion concentration

inferred from mutant phenotype

(Cohn et al., 2015)

involved_in response to odorant

inferred from mutant phenotype

(Cohn et al., 2015)

involved_in response to starvation

inferred from mutant phenotype

(Inagaki et al., 2012)

involved_in response to sucrose

inferred from mutant phenotype

(Inagaki et al., 2012)

involved_in thermosensory behavior

inferred from mutant phenotype

(Bang et al., 2011)

involved_in thermotaxis

inferred from mutant phenotype

(Bang et al., 2011)

involved_in visual learning

inferred from mutant phenotype

(assigned by UniProt )

(Gotzes et al., 1994)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in dopamine receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in dendrite

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

located_in integral component of plasma membrane

inferred from sequence model

(Gotzes et al., 1994)

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

DOPAMINE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (P41596)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

DOPAMINE RECEPTORS -: Dopamine GPCRs are Class A GPCRs. Dopamine is a neurotransmitter involved in a variety of behavioural and physiological functions such as memory, arousal and mating behaviour. (Adapted from PMID:17088868 and FBrf0219823).

Protein Function (UniProtKB)

Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.

(UniProt, P41596)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dop1R1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Double stop-codon suppression (UGA, UGA) postulated; FBrf0216884.

Transposon inserted in intron

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dop1R1-RB

FBtr0290283

NM_057659

2661

496

Dop1R1-RC

FBtr0301351

NM_001170136

2616

481

Dop1R1-RD

FBtr0308191

NM_001260163

14565

511

Dop1R1-RE

FBtr0330711

NM_001275634

2661

560

Dop1R1-RF

FBtr0346763

NM_001316525

2661

535

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Dop1R1-PB

FBpp0288722

54.4

496

8.37

NP_477007

AAF55030

Dop1R1-PC

FBpp0290565

52.9

481

8.65

NP_001163607

ACZ94904

Dop1R1-PD

FBpp0300511

56.2

511

8.37

NP_001247092

AFH06410

Dop1R1-PE

FBpp0303554

60.9

560

7.33

NP_001262563

AGB95944

Dop1R1-PF

FBpp0312358

58.4

535

8.04

NP_001303454

ALI30568

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop1R1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dop1R1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

DopR transcripts appear to be maternally inherited and are abundant in syncytial stages. At these and cellular stages, transcripts are restricted to apical regions of the cortical, peripheral cytoplasm. Later, DopR transcripts are specifically associated with the extending germ band and are excluded from the invaginating posterior mesoderm and the presumptive head regions. DopR transcripts are uniformly distributed in all developing tissues in later stages of embryogenesis.

(Sugamori et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

Tvb neuron

(Baumgardt et al., 2007)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

DopR protein is detected in the ellipsoid body, in the rings innervated by R3 and R4d ring neurons. In the fan-shaped body, strong expression is observed in the dorsal and ventral layers, with weaker labelling observed in the central layers. In the nodulus, strong expression is observed in layers I and II.

(Kahsai et al., 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: PBac{GAL4D,EYFP}Dop1R1^PL00420

Stage

Tissue/Position (including subcellular localization)

Reference

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dop1R1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dop1R1

View exonic expression by tissue for Dmel\Dop1R1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0011582

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9652-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0011582

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dop1R1

Transgenic constructs containing regulatory region of Dop1R1

Deletions and Duplications ( 3 )

Disrupted in

Df(3R)Exel7321

(Ryder, 2004.4.26)

Df(3R)Exel7359

(Ryder, 2004.4.26)

In(3LR)234

(Kim et al., 2007)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^elav.PLu

Dop1R1^GD688

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Dop1R1^GD688

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Dop1R1^GD688

viable

viable, with Scer\GAL4^Mef2.PR

Dop1R1^GD688

Sterility

Allele

fertile

Other Phenotypes

Allele

chemosensitive behavior defective | dominant | larval stage

Dop1R1^f02676

chemosensitive behavior defective | larval stage, with Scer\GAL4^NPF.1

Dop1R1^KK102341

courtship behavior defective | male

Dop1R1^attP

courtship behavior defective | male, with Scer\GAL4¹⁴⁷¹

Dop1R1^KK102341

courtship behavior defective | male, with Scer\GAL4^Tab2-201Y

Dop1R1^KK102341

feeding behavior defective | dominant | larval stage

Dop1R1^f02676

feeding behavior defective | larval stage, with Scer\GAL4^NPF.1

Dop1R1^KK102341

flight defective, with Scer\GAL4^elav.PLu

Dop1R1^GD688

flight defective, with Scer\GAL4^Mef2.PR

Dop1R1^GD688

hyperactive | chemical conditional

Dop1R1^f02676

hypoactive | adult stage

Dop1R1^f02676

hypoactive | chemical conditional

Dop1R1^PL00420

hypoactive | chemical conditional (with Df(3R)ED5634)

Dop1R1^f02676

learning defective

Dop1R1^f02676

learning defective, with Scer\GAL4^c747

Dop1R1^UAS.cLa

learning defective (with In(3LR)234)

Dop1R1^f02676

learning defective | male

Dop1R1^attP

learning defective | male, with Scer\GAL4¹⁴⁷¹

Dop1R1^KK102341

learning defective | male, with Scer\GAL4^Tab2-201Y

Dop1R1^KK102341

learning defective | recessive

Dop1R1^f02676

memory defective

Dop1R1^f02676

memory defective, with Dop1R1^f02676, Scer\GAL4^ey-OK107

Dop1R1^UAS.cKa

memory defective, with Dop1R1^UAS.cKa, Scer\GAL4^ey-OK107

Dop1R1^f02676

memory defective | adult stage

Dop1R1^f02676

memory defective | adult stage, with Hsap\RELA^AD.R13F02, Scer\GAL4^DBD.R44E04

Dop1R1^HMC02344

memory defective | adult stage, with Scer\GAL4^c739

Dop1R1^HMC02344

memory defective | adult stage, with Scer\GAL4^nSyb.PS

Dop1R1^HMC05200

neurophysiology defective

Dop1R1^attP

sleep defective | adult stage

smell perception defective

Dop1R1^attP

some die during immature adult stage | recessive, with Scer\GAL4^elav.PLu

Dop1R1^GD688

thermotaxis defective | adult stage

Dop1R1^PL00420

thermotaxis defective | adult stage (with Df(3R)red-P52)

Dop1R1^PL00420

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DRD5

9 of 15

Yes

Hsap\DRD1

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\OR5T2

1 of 15

Yes

Hsap\OR5T3

1 of 15

Yes

Hsap\OR6T1

1 of 15

Yes

Hsap\OR10H1

1 of 15

Yes

Hsap\OR10H2

1 of 15

Yes

Hsap\OR10H3

1 of 15

Yes

Hsap\OR10H4

1 of 15

Yes

Hsap\OR10H5

1 of 15

Yes

Hsap\OR10J5

1 of 15

Yes

Hsap\OR10J6P

1 of 15

Yes

Hsap\OR11H4

1 of 15

Yes

Hsap\OR11H7

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Drd1

7 of 15

Yes

Mmus\Drd5

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Olfr16

1 of 15

Yes

Mmus\Olfr55

1 of 15

Yes

Mmus\Olfr63

1 of 15

Yes

Mmus\Olfr239

1 of 15

Yes

Mmus\Olfr472

1 of 15

Yes

Mmus\Olfr473

1 of 15

Yes

Mmus\Olfr474

1 of 15

Yes

Mmus\Olfr479

1 of 15

Yes

Mmus\Olfr509

1 of 15

Yes

Mmus\Olfr746

1 of 15

Yes

Mmus\Olfr747

1 of 15

Yes

Mmus\Olfr748

1 of 15

Yes

Mmus\Olfr749

1 of 15

Yes

Mmus\Olfr1093

1 of 15

Yes

Mmus\Olfr1094

1 of 15

Yes

Mmus\Olfr1102

1 of 15

Yes

Mmus\Olfr1564

1 of 15

Yes

Rattus norvegicus (Norway rat) (26)

Rnor\Drd1

7 of 13

Yes

Rnor\Drd5

7 of 13

Yes

Rnor\Htr6

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Htr4

1 of 13

Rnor\LOC100909683

1 of 13

Yes

Rnor\Olr240

1 of 13

Yes

Rnor\Olr241

1 of 13

Yes

Rnor\Olr245

1 of 13

Yes

Rnor\Olr515

1 of 13

Yes

Rnor\Olr517

1 of 13

Yes

Rnor\Olr518

1 of 13

Yes

Rnor\Olr519

1 of 13

Yes

Rnor\Olr1091

1 of 13

Yes

Rnor\Olr1093

1 of 13

Yes

Rnor\Olr1095

1 of 13

Yes

Rnor\Olr1576

1 of 13

Yes

Rnor\Olr1622

1 of 13

Yes

Rnor\Olr1631

1 of 13

Yes

Rnor\Olr1632

1 of 13

Yes

Rnor\Olr1635

1 of 13

Yes

Rnor\Olr1875

1 of 13

Yes

Rnor\Taar7h

1 of 13

Xenopus tropicalis (Western clawed frog) (7)

Xtro\drd1c

8 of 12

Yes

Xtro\drd1

7 of 12

Yes

Xtro\drd5

3 of 12

Yes

Xtro\adrb1

1 of 12

Xtro\adrb2

1 of 12

Xtro\htr6

1 of 12

Yes

Xtro\LOC100490372

1 of 12

Danio rerio (Zebrafish) (32)

Drer\drd6b

8 of 15

Yes

Drer\drd1a

7 of 15

Yes

Drer\drd1b

7 of 15

Yes

Drer\drd7

7 of 15

Yes

Drer\LOC563567

4 of 15

Yes

Drer\LOC567498

4 of 15

Yes

Drer\hrh2b

2 of 15

Yes

Drer\taar12m

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\htr4

1 of 15

Drer\htr6

1 of 15

Yes

Drer\si:dkey-247m21.3

1 of 15

Drer\taar10

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\taar19g

1 of 15

Yes

Drer\taar19s

1 of 15

Yes

Drer\taar20b1

1 of 15

Yes

Drer\taar20j

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\dop-1

9 of 15

Yes

Cele\ser-5

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906ES )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21941

Drosophila persimilis

Dper\GL23301

Drosophila willistoni

Dwil\GK10900

Drosophila virilis

Dvir\GJ22610

Drosophila mojavensis

Dmoj\GI24543

Drosophila grimshawi

Dgri\GH19686

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508L5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017402

Glossina morsitans

Tsetse fly

Gmor\GMOY002017

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13459

Mayetiola destructor

Hessian fly

Mdes\Mdes009052

Anopheles darlingi

American malaria mosquito

Adar\ADAC007810

Anopheles gambiae

Malaria mosquito

Agam\GPRDOP1

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000647

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0JYM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002277

Bombyx mori

Silkmoth

Bmor\BGIBMGA002275

Bombyx mori

Silkmoth

Bmor\BGIBMGA002276

Danaus plexippus

Monarch butterfly

Dple\DPOGS202585-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL003917

Apis florea

Little honeybee

Aflo\2379349252

Apis florea

Little honeybee

Aflo\2161031906

Apis mellifera

Western honey bee

Amel\GB50192

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14827

Bombus terrestris

Buff-tailed bumblebee

Bter\15205619

Linepithema humile

Argentine ant

Lhum\LH18257

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002cdf

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001652

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04374

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04375

Tribolium castaneum

Red flour beetle

Tcas\TC012447

Pediculus humanus

Human body louse

Phum\PHUM434420

Rhodnius prolixus

Kissing bug

Rpro\RPRC014093

Cimex lectularius

Bed bug

Clec\CLEC002966

Cimex lectularius

Bed bug

Clec\CLEC002967

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006935

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10284

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0923 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012831

Ixodes scapularis

Black-legged tick

Isca\ISCW001496

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63867.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g05500

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_23898

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06VI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Htr1b_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Htr1aL_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-5ht1a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hrh1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-MachrM4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-5ht1F

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Drd1_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Adra1a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-MachrM5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Drd1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-5ht7

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hrh2_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Htr1b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_009149gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-5ht2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-MachrM3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Drd2L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Htr1a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Drd2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Drd1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Drd1_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hrh2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Htr1aL_4

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018919

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019975

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020513

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004433

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000013284

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004781

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003264

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024198

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008896

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000002943

Ciona intestinalis

Vase tunicate

Cint\LOC100176265

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000014975

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000015953

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026029

Gallus gallus

Domestic chicken

Ggal\HTR1A

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000023521

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008949

Gallus gallus

Domestic chicken

Ggal\HTR1D

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000009640

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000024171

Gallus gallus

Domestic chicken

Ggal\HTR2A

Gallus gallus

Domestic chicken

Ggal\HTR1F

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000469

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003050

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000007794

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000019018

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000006362

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000004066

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000015974

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000006540

Gallus gallus

Domestic chicken

Ggal\HTR2C

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003270

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000015117

Gallus gallus

Domestic chicken

Ggal\HTR1E

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001416

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000010778

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001383

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000005085

Gallus gallus

Domestic chicken

Ggal\HTR1B

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000004930

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000013994

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000013995

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000012040

Gallus gallus

Domestic chicken

Ggal\Gga.320

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008365

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000012894

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026998

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000015608

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000016013

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (19)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

DRD5; dopamine receptor D5

model of attention deficit hyperactivity disorder

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DRD5; dopamine receptor D5

9 of 15

126453

attention deficit hyperactivity disorder

DRD1; dopamine receptor D1

6 of 15

126449

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Dop1R1 - mir-276a

quantitative reverse transcription pcr

(Li et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

DopEcR

suppressible

Dop1R1

(Petruccelli et al., 2016)

suppressible

(Li et al., 2013)

suppressible

(Sun et al., 2018, Liu et al., 2012, Liu et al., 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0011582

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41726

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-54

Cytogenetic map

88A10-88A12

Sequence location

3R:14,165,379..14,214,810 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88A10-88A12

Limits computationally determined from genome sequence between P{PZ}flfl⁰¹⁹⁴⁹ and P{lacW}trx^j14A6&P{PZ}trx⁰⁰³⁴⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

88-89

(Gibson, 1999.7.26)

35E-35F

(determined by in situ hybridisation)

(Gotzes et al., 1994)

Experimentally Determined Recombination Data

Location

3-54

(FlyBase, 2016)

3-52.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

83014

y¹; M{WKO.1-B1}ZH-86Fb

31765

y¹ v¹; P{TRiP.HM04077}attP2

84714

w^*; TI{GAL4}Dop1R1^{KOGal4.CRISPR}

64052

w¹¹¹⁸; PBac{IT.GAL4}Dop1R1^0966-G4

43667

y¹ w^*; Mi{MIC}Dop1R1^MI01629

43773

y¹ w^*; Mi{MIC}Dop1R1^MI04437

62193

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05200}attP40

68234

y¹ v¹; P{UAS-Dop1R1-Tango}attP2/TM6C, Sb¹ Tb¹

36428

y¹ w^*; Mi{MIC}Dop1R1^MI03085/TM3, Sb¹ Ser¹

55239

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02344}attP2/TM3, Sb¹

VDRC

v330371

P{VSH330371}attP40

v107058

P{KK102341}VIE-260B

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (142)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011582

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011582

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41726

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Gruntenko et al., 2012, Kong et al., 2010, Lebestky et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: DopR CG9652

(Zheng, 1999.11)

Source for identity of: Dop1R1 DopR

(FlyBase, 2009-)

Source for database merge of

Additional comments

nAcRα-34E is not DopR.

(Ashburner et al., 1999.10.12)

Other Comments

Certain domains of receptor molecules may vary significantly in different strains of Drosophila but the structural changes do not alter the functional properties of the expressed polypeptides.

(Gotzes and Baumann, 1996)

A DopR cDNA has been cloned and sequenced.

(Sugamori et al., 1995)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41726

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P41596

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011582

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dop1R1_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0011582

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41726

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012447

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9652

modMine - A data warehouse for the modENCODE project

FBgn0011582

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0011582

DRSC - Results frm RNAi screens

FBgn0011582

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0011582

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9652-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011582

FlyMine - An integrated database for Drosophila genomics

FBgn0011582

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41726

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (34)

Reported As

Symbol Synonym

CG9652

(Ashraf et al., 2020, Kondo et al., 2020, Meadows, 2017.1.11, Yu et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Selcho et al., 2009, Johnson et al., 2008, Ni et al., 2008, Hauser et al., 2006, Srivastava et al., 2005)

D-Dop1

(Gotzes et al., 1994)

D1R1

(Akiba et al., 2020)

DA1

(Dylla et al., 2013, Seugnet et al., 2009, Park et al., 2004)

DR1

(Stern et al., 2019, Yang et al., 2015)

DRD1

(Jia et al., 2016)

DmDOP1

(Qi et al., 2017, Yuan and Lee, 2007)

DmDop1

(Kong et al., 2010, Hearn et al., 2002, Gotzes and Baumann, 1996)

Dmdop1

(Kehren and Baumann, 2005, Blenau and Baumann, 2001)

Dop1-R1

(Ko et al., 2017, Suh et al., 2017)

Dop1R

(Kottler et al., 2019)

DopR

(Highfill et al., 2019, Li et al., 2019, Ly et al., 2018, Ueno et al., 2017, Zajitschek et al., 2017, Crocker et al., 2016, Petruccelli et al., 2016, Pitmon et al., 2016, Zhang et al., 2016, de Taffin et al., 2015, Shih et al., 2015, Tomita et al., 2015, Ashwal-Fluss et al., 2014, Singh et al., 2014, Alekseyenko et al., 2013, Argue and Neckameyer, 2013, Argue and Neckameyer, 2013, Dubnau and Chiang, 2013, Kottler et al., 2013, Li et al., 2013, Perisse et al., 2013, Ueno et al., 2013, Wang et al., 2013, Chen et al., 2012, Gruntenko et al., 2012, Izutsu et al., 2012, Kahsai et al., 2012, Kaun et al., 2012, Liu et al., 2012, Marella et al., 2012, Neckameyer and Bhatt, 2012, Rauschenbach et al., 2012, Bang et al., 2011, Jungreis et al., 2011, Kong et al., 2010, Lebestky et al., 2009, Hoopfer et al., 2008, Johnson et al., 2008, Baumgardt et al., 2007, Baumgardt et al., 2007, Dietzl et al., 2007, Draper et al., 2007, Jones, 2007, Franchini et al., 2004)

DopR35F

(Feng et al., 1996)

Dumb

(Sun et al., 2018, Zhang et al., 2016)

dDA1/DmDOP1

(Kim et al., 2003)

dopr

(Naganos et al., 2016)

Name Synonyms

D1 dopamine receptor

(Dylla et al., 2013, Lebestky et al., 2009)

D1-Like Dopamine Receptor

(Kong et al., 2010)

D1-like DA receptor

(Kong et al., 2010)

D1-like receptor

(Rauschenbach et al., 2011, Gilbert et al., 2000)

D1 dopamine receptor

(Neckameyer and Bhatt, 2012)

DA D1-like receptor

(Srivastava et al., 2005)

Dopamine 1-like receptor 1

Dopamine receptor

dDA1

(Dissel et al., 2015)

dopamine 1 receptor

(Seugnet et al., 2009)

dopamine D1 receptor

(Rothenfluh and Heberlein, 2002)

dopamine D1-like receptor

(Seugnet et al., 2008, Niznik, 1995.3.2)

dopamine receptor

(Johnson et al., 2008, Jones, 2007, Baumann, 1994.1.21)

dopaminergic receptor

(Zhang et al., 2016)

dumb

(Pitmon et al., 2016, Faville et al., 2015)

dumb DA receptor

(Musso et al., 2015)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (225)

The following external sites may use different assemblies or annotations than FlyBase.

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