secreted glycosyltransferase involved boundary formation - Notch antagonist that functions by targeting extracellular domain of Notch - Chip and Beadex function antagonistically on Notch signaling through directly regulation of transcription
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.56
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fng using the Feature Mapper tool.
Comment: reported as posterior spiracle specific anlage
fng transcript is expressed 4-5 polar follicle cell precursor cells in stage 1-4 egg chambers, and later in the 2 polar cells that emerge from the prepolar group.
fng transcript is expressed in follicle cells starting in germarium region 2b. Expression is detected in anterior and posterior follicle cells in stage S2-S4, in all follicle cells in stage S5, in anterior and posterior polar follicle cells in stage S6-S9. At stage S10, expression is detected in all follicle cells except anterior-dorsal follicle cells.
fng is first detected in the wing disc in second instar larvae where it is restricted to the dorsal region of the disc. Expression remains in the dorsal part of the wing disc through the first half of the third instar after which some weak expression begins to appear in ventral regions outside of the wing pouch. In addition, fng expression is lost in some regions that will give rise to the notum. By the end of third instar, expression is lost in some dorsal regions within the wing pouch and becomes strong in proximal regions of the ventral wing.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fng in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: fng l(3)rG554
fng plays a key role in positioning N activation during early oogenesis. fng is required cell-autonomously in the somatic polar cells for follicle formation and also for polar cell fate. fng is required non-autonomously to define the number and organization of stalk cells.
fng does not exert its effect outside the cell, but rather acts in the golgi apparatus, apparently as a glycosyltransferase.
fng is essential in oogenesis for the proper formation of the egg chamber and for epithelial morphogenesis.
ap mediates cell interactions across the DV axis of the wing by regulating the expression of Ser and fng. In ap mutants the wing is lost, this phenotype can be rescued by ectopic expression of either Ser or fng and the resulting wings have both dorsal and ventral cell fates.
Ser does not signal in the dorsal regions of the developing imaginal wing disc due to the action of the fng gene product. Ectopic expression studies reveal the regulation of Ser by fng occurs at the level of protein and not Ser transcription.
fng and Ser are distinct components of a single ap-regulated cell recognition and signal induction mechanism. Clonal analysis demonstrates that fng serves as a boundary-determining molecule such that Ser is induced wherever cells expressing fng and cells not expressing fng are juxtaposed.