FB2025_04 , released October 2, 2025
Gene: Dmel\Iswi
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General Information
Symbol
Dmel\Iswi
Species
D. melanogaster
Name
Imitation SWI
Annotation Symbol
CG8625
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011604
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502). (UniProt, Q24368)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

NURF, CHRAC, ACF, dISWI, dNURF

Key Links
Genomic Location
Cytogenetic map
49B10-49B10
Sequence location
Recombination map
2-67
RefSeq locus
NT_033778 REGION:12636671..12640628
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (36 terms)
Molecular Function (12 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
enables ATP hydrolysis activity
inferred from direct assay
(Emelyanov et al., 2010, Varga-Weisz et al., 1997)
enables ATP-dependent activity, acting on DNA
inferred from direct assay
(Fyodorov and Kadonaga, 2002, Georgel et al., 1997)
inferred from genetic interaction with FLYBASE:His3; FB:FBgn0001199
(Georgel et al., 1997)
inferred from genetic interaction with FLYBASE:His4; FB:FBgn0001200
(Georgel et al., 1997)
enables ATP-dependent chromatin remodeler activity
inferred from direct assay
(Emelyanov et al., 2010, Burgio et al., 2008, Ito et al., 1999)
enables DNA-binding transcription factor binding
inferred from physical interaction with FLYBASE:pnr; FB:FBgn0003117
(Vanolst et al., 2005)
enables histone octamer slider activity
inferred from direct assay
(Eberharter et al., 2001, Langst and Becker, 2001, Hamiche et al., 1999)
enables nucleosome array spacer activity
inferred from direct assay
(Ito et al., 1997, Varga-Weisz et al., 1997)
enables protein binding
inferred from physical interaction with FLYBASE:Chi; FB:FBgn0013764
(Vanolst et al., 2005)
inferred from physical interaction with FLYBASE:tou; FB:FBgn0033636
(Vanolst et al., 2005)
inferred from physical interaction with FLYBASE:Acf; FB:FBgn0027620
(Fyodorov and Kadonaga, 2002)
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR044754
(InterPro Project Members, 2004-)
enables ATP hydrolysis activity
inferred from sequence model
(Tsukiyama et al., 1995)
enables ATP-dependent chromatin remodeler activity
inferred from sequence model
(Tsukiyama et al., 1995)
enables chromatin binding
inferred from biological aspect of ancestor with PANTHER:PTN004198564
(GO Reference Genome Project, 2011-)
enables DNA binding
inferred from electronic annotation with InterPro:IPR015194, InterPro:IPR015195, InterPro:IPR036306
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN004198564
(GO Reference Genome Project, 2011-)
enables nucleosome array spacer activity
inferred from biological aspect of ancestor with PANTHER:PTN004198564
(GO Reference Genome Project, 2011-)
enables nucleosome binding
inferred from electronic annotation with InterPro:IPR015194, InterPro:IPR036306
(InterPro Project Members, 2004-)
enables nucleotide binding
traceable author statement
(Ito et al., 1997)
Biological Process (15 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from direct assay
(Mizuguchi et al., 1997)
inferred from mutant phenotype
(Corona et al., 2007)
involved_in chromatin remodeling
inferred from direct assay
(Emelyanov et al., 2012, Mizuguchi et al., 2001)
involved_in DNA replication-dependent chromatin assembly
inferred from direct assay
(Ito et al., 1999, Ito et al., 1997)
involved_in heterochromatin formation
inferred from physical interaction with FLYBASE:dom; FB:FBgn0020306,FLYBASE:CG8677; FB:FBgn0026577
(Hanai et al., 2008)
involved_in negative regulation of DNA-templated transcription
inferred from mutant phenotype
(Liu et al., 2008)
involved_in nuclear speck organization
inferred from mutant phenotype
(Onorati et al., 2011)
involved_in nucleosome organization
inferred from direct assay
(Eberharter et al., 2001, Hamiche et al., 1999, Varga-Weisz et al., 1997)
involved_in positive regulation of DNA-templated transcription
inferred from direct assay
(Mizuguchi et al., 2001)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Vanolst et al., 2005)
inferred from genetic interaction with FLYBASE:EcR; FB:FBgn0000546
(Badenhorst et al., 2005)
involved_in regulation of circadian rhythm
inferred from mutant phenotype
(Matsumoto et al., 2007)
involved_in regulation of DNA-templated transcription
inferred from mutant phenotype
(Corona et al., 2007)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Li et al., 2010)
involved_in sperm DNA condensation
inferred from mutant phenotype
(Doyen et al., 2015)
involved_in sperm DNA decondensation
inferred from mutant phenotype
(Doyen et al., 2015)
involved_in spermatogenesis
inferred from mutant phenotype
(Doyen et al., 2015)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in chromatin remodeling
inferred from electronic annotation with InterPro:IPR015194, InterPro:IPR015195, InterPro:IPR036306
(InterPro Project Members, 2004-)
traceable author statement
(Brehm et al., 2000)
inferred from sequence or structural similarity with SGD:S000005816
(Elfring et al., 1994)
involved_in heterochromatin formation
inferred from biological aspect of ancestor with PANTHER:PTN004198564
(GO Reference Genome Project, 2011-)
involved_in positive regulation of DNA-templated transcription
traceable author statement
(Badenhorst et al., 2002)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004198564
(GO Reference Genome Project, 2011-)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
part_of ACF complex
inferred from direct assay
(Ito et al., 1999, Ito et al., 1997)
part_of CHRAC
inferred from direct assay
(Varga-Weisz et al., 1997)
located_in chromatin
inferred from direct assay
(Li et al., 2010, Hanai et al., 2008)
part_of ISWI-type complex
inferred from direct assay
(Emelyanov et al., 2012)
located_in nucleus
inferred from direct assay
(Tsukiyama et al., 1995)
part_of NURF complex
inferred from direct assay
(Kwon et al., 2009, Tsukiyama et al., 1995)
colocalizes_with polytene chromosome
inferred from direct assay
(Emelyanov et al., 2012)
located_in polytene chromosome
inferred from direct assay
(Burgio et al., 2008)
part_of RSF complex
inferred from physical interaction with FLYBASE:CG8677; FB:FBgn0026577
(Hanai et al., 2008)
part_of transcription regulator complex
inferred from physical interaction with FLYBASE:Trf2; FB:FBgn0261793
(Hochheimer et al., 2002)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
part_of ACF complex
non-traceable author statement
(Lusser and Kadonaga, 2003)
traceable author statement
(Badenhorst et al., 2002)
part_of CHRAC
traceable author statement
(Badenhorst et al., 2002)
non-traceable author statement
(Lusser and Kadonaga, 2003)
is_active_in chromatin
inferred from biological aspect of ancestor with PANTHER:PTN001649185
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001649185
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR015195
(InterPro Project Members, 2004-)
part_of NURF complex
traceable author statement
(Lusser and Kadonaga, 2003, Badenhorst et al., 2002, Gdula et al., 1998, Ito et al., 1997)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. (Q24368)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Group (FlyBase)
NUCLEOSOME REMODELING FACTOR -
Nucleosome Remodeling Factor (NURF) is an ISWI ATPase-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. (Adapted from FBrf0228922 and FBrf0228920).
ACF COMPLEX -
ACF is an ISWI-containing chromatin remodeling complex that optimizes nucleosome spacing to promote chromatin assembly. (Adapted from FBrf0228920).
TORC REMODELING COMPLEX -
ToRC (Toutatis-containing chromatin remodeling complex) is ISWI ATPase-containing complex that facilitates nucleosome assembly. (Adapted from FBrf0217777).
CHROMATIN ACCESSIBILITY COMPLEX -
CHRAC is an ISWI-containing chromatin remodeling complex that optimizes nucleosome spacing to promote chromatin assembly and the repression of transcription. (Adapted from FBrf0228920).
NORC COMPLEX -
NoRC (Nucleolar remodeling complex) is an ISWI ATPase-containing complex interacts involved in repressing rDNA transcription. (Adapted from PMID:25533489).
SNF2-LIKE CHROMATIN REMODELERS -
Snf2-like chromatin remodelers are a family of helicase-like proteins that direct energy derived from ATP hydrolysis into the mechanical remodelling of chromatin structure. They are so-called due to the presence of a domain homologous to the helicase-like ATPase domain of the S. cerevisiae Snf2 protein. This domain, the Snf2 domain, consists of two tandem RecA-like folds and contains seven conserved helicase-related sequence motifs that classify it as part of the helicase superfamily 2 (SF2). However, Snf2 proteins are not bona fide helicases, lacking the ability to separate nucleic acid strands. Instead, Snf2 proteins are DNA translocases that apply an ATP-dependent torsional strain to DNA, which provides the necessary force to remodel nucleosomes or in some cases other DNA-protein complexes. (Adapted from PMID:21862382.)
REMODELING AND SPACING FACTOR COMPLEX -
Remodeling and spacing factor (RSF) is an ISWI-containing chromatin remodeling complex. (Adapted from FBrf0210332.)
Protein Function (UniProtKB)
Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex) (PubMed:10856248, PubMed:11447119). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:12502740, PubMed:16264191, PubMed:8521501, PubMed:8521502).
(UniProt, Q24368)
Summary (Interactive Fly)

transcription factor - ATPase domain - bromodomain - gene activator - a component of a nucleosome remodeling protein complex

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Iswi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24368)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Iswi-RA
FBtr0087841
NM_078995
3647
1027
Iswi-RB
FBtr0087842
NM_165930
3541
1027
Iswi-RC
FBtr0087843
NM_165931
3585
1027
Additional Transcript Data and Comments
Reported size (kB)

3.6 (northern blot)

(Elfring et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Iswi-PA
FBpp0086954
118.9
1027
8.51
Q24368
NP_523719
AAF58479
Iswi-PB
FBpp0086955
118.9
1027
8.51
Q24368
NP_725203
AAM68637
Iswi-PC
FBpp0086956
118.9
1027
8.51
Q24368
NP_725204
AAM68638
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1027 aa isoforms: Iswi-PA, Iswi-PB, Iswi-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

140 (kD)

(Tsukiyama et al., 1995)

1027 (aa); 119 (kD predicted)

(Elfring et al., 1994)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the NURF complex composed of Caf1-55, E(bx), Nurf-38 and Iswi (PubMed:8521502). Component of the chromatin accessibility complex (CHRAC), composed of Chrac-14, Chrac-16, Acf and Iswi (PubMed:10856248, PubMed:11447119). Interacts directly with Chrac-14 and this interaction is further stabilized by associated Chrac-16 (PubMed:10856248).

(UniProt, Q24368)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Iswi using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.42

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 4 -- 12
organism | ubiquitous | uniform
(Elfring et al., 1994)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 13 -- 17
larval central nervous system
(Elfring et al., 1994)
gonad
(Elfring et al., 1994)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- pupal stage
(Elfring et al., 1994)
embryonic stage 1 -- 12
organism
(Elfring et al., 1994)
embryonic stage 1 -- 15
organism | intense
(Elfring et al., 1994)
embryonic stage 13 -- 17
gonad
(Elfring et al., 1994)
presumptive embryonic/larval central nervous system
(Elfring et al., 1994)
embryonic stage 16 -- third instar larval stage
organism | faint
(Elfring et al., 1994)
P-stage
organism
(Elfring et al., 1994)
adult stage | female
(Elfring et al., 1994)
organism | faint
(Elfring et al., 1994)
oogenesis
oocyte
(Elfring et al., 1994)
Additional Descriptive Data

The pattern of Iswi and brm transcript expression are very similar. Iswi transcript levels are highest in oocytes and early embryos, and lower in late embryos and larvae. Iswi is barely detected in pupae and adult females, but is not detected in adult males. In embryos, both Iswi and brm transcripts are uniformly distributed until germ band retraction. Both gradually become restricted to the central nervous system and are undetectable near hatching. Unlike brm, Iswi transcripts are also detected in gonads after germ band retraction.

(Elfring et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
hub cell
(Cherry and Matunis, 2010)
male germline stem cell
(Cherry and Matunis, 2010)
cyst progenitor cell
(Cherry and Matunis, 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Ito et al., 1999, Tsukiyama et al., 1995)
Additional Descriptive Data

Iswi protein is detected in all nuclei of embryos, as well as in diploid and polyploid nuclei of third instar larvae.

(Cherry and Matunis, 2010, Tsukiyama et al., 1995)

Iswi protein is detected throughout embryogenesis and at significantly lower levels in larvae, pupae, and adults.

(Ito et al., 1999)

Iswi protein is detected in all developmental stages. It is at highest levels in mid-embryogenesis, with lower levels in larvae, pupae, and adults. Expression in adult males is ~50-fold lower than in 0-12 hr embryos. Expression in the developing embryo can be as high as 100,000 molecules of Iswi protein per cell.

(Tsukiyama et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of ACF complex
inferred from direct assay
(Ito et al., 1999, Ito et al., 1997)
part_of CHRAC
inferred from direct assay
(Varga-Weisz et al., 1997)
located_in chromatin
inferred from direct assay
(Li et al., 2010, Hanai et al., 2008)
part_of ISWI-type complex
inferred from direct assay
(Emelyanov et al., 2012)
located_in nucleus
inferred from direct assay
(Tsukiyama et al., 1995)
part_of NURF complex
inferred from direct assay
(Kwon et al., 2009, Tsukiyama et al., 1995)
colocalizes_with polytene chromosome
inferred from direct assay
(Emelyanov et al., 2012)
located_in polytene chromosome
inferred from direct assay
(Burgio et al., 2008)
part_of RSF complex
inferred from physical interaction with FLYBASE:CG8677; FB:FBgn0026577
(Hanai et al., 2008)
part_of transcription regulator complex
inferred from physical interaction with FLYBASE:Trf2; FB:FBgn0261793
(Hochheimer et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Iswi in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Iswi
Transgenic constructs containing regulatory region of Iswi
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7121
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL469B
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4insc-Mz1407
lethal (with Iswi1)
lethal (with Iswi2)
lethal | heat sensitive, with Iswi2, Scer\GAL4da.G32
lethal | heat sensitive, with IswiK159R.UAS.Tag:HA, Scer\GAL4da.G32
lethal | male, with Scer\GAL4elav.PU
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage (with Iswi1)
lethal - all die before end of larval stage (with Iswi2)
lethal - all die during embryonic stage | maternal effect
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
male sterile, with Scer\GAL4path-c135
Other Phenotypes
Allele
abnormal behavior | adult stage, with Scer\GAL4elav.PU
abnormal courtship behavior, with Scer\GAL4elav.PU
abnormal eye color | somatic clone
abnormal locomotor behavior | adult stage, with Scer\GAL4elav.PU
abnormal locomotor rhythm, with Scer\GAL4tim.UAS
abnormal locomotor rhythm | adult stage, with Scer\GAL4elav.PU
abnormal mitotic cell cycle
abnormal mitotic cell cycle | embryonic stage | maternal effect
abnormal neuroanatomy | adult stage, with Scer\GAL4ase.PU
abnormal neuroanatomy | adult stage, with Scer\GAL4elav.PU
abnormal neuroanatomy | adult stage, with Scer\GAL4ey-OK107
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR27G10
abnormal neuroanatomy | adult stage, with Scer\GAL4wor.PU
abnormal neuroanatomy | third instar larval stage
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size, with Scer\GAL4tj.PU
abnormal size | adult stage, with Scer\GAL4ey.PH
abnormal size | adult stage, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
abnormal sleep | adult stage, with Scer\GAL4ase.PU
abnormal sleep | adult stage, with Scer\GAL4elav.PU
abnormal sleep | adult stage, with Scer\GAL4wor.PU
decreased body size | third instar larval stage
decreased efficacy of memory | adult stage, with Scer\GAL4elav.PU
decreased fecundity | male
decreased occurrence of cell division | third instar larval stage
decreased size | adult stage, with Scer\GAL4elav.PU
decreased sleep | adult stage, with Scer\GAL4ase.PU
decreased sleep | adult stage, with Scer\GAL4elav.PU
decreased sleep | adult stage, with Scer\GAL4wor.PU
increased cell death, with Scer\GAL4tj.PU
increased cell death, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
increased cell death | larval stage, with Scer\GAL4ptc-559.1
increased cell number | adult stage, with Scer\GAL4elav.PU
non-enhancer of variegation, with In(1)wm4
non-suppressor of variegation, with In(1)wm4
some die during larval stage (with Iswi1)
some die during larval stage (with Iswi2)
visible, with Iswi2, Scer\GAL4ey.PH
visible, with IswiK159R.UAS.Tag:HA, Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-537.4
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4ey.PH
visible | adult stage, with Scer\GAL4nub.PK
visible | somatic clone
visible | third instar larval stage
wild-type
Phenotype manifest in
Allele
adult dorsal fan-shaped body, with Scer\GAL4elav.PU
adult head | somatic clone
adult mushroom body, with Scer\GAL4ase.PU
adult mushroom body, with Scer\GAL4GMR27G10
adult mushroom body, with Scer\GAL4wor.PU
adult thoracic segment | somatic clone
anterior crossvein, with Scer\GAL4nub.PK
condensed chromosome, with Iswi2, Scer\GAL4da.G32
condensed chromosome, with IswiK159R.UAS.Tag:HA, Scer\GAL4da.G32
condensed chromosome, with Scer\GAL4da.G32
dendrite | third instar larval stage
dendritic branch | decreased number | third instar larval stage
dorsocentral bristle
dorsocentral bristle, with Scer\GAL4pnr-MD237
egg, with Scer\GAL4tj.PU
egg chamber, with Scer\GAL4tj.PU
egg chamber, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
embryonic/larval hemocyte | increased number
embryonic/larval salivary gland | larval stage | male (with Iswi1)
embryonic/larval salivary gland | larval stage | male (with Iswi2)
euchromatin, with Scer\GAL4da.G32
eye, with Iswi2, Scer\GAL4ey.PH
eye, with IswiK159R.UAS.Tag:HA, Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye | somatic clone
eye photoreceptor cell | somatic clone
female germline stem cell | germline clone
follicle cell, with Scer\GAL4tj.PU
follicle stem cell | somatic clone
genitalia | somatic clone
germarium, with Scer\GAL4tj.PU
hemocyte | increased number (with Iswi1)
hemocyte | increased number (with Iswi2)
larval brain | adult stage, with Scer\GAL4elav.PU
larval brain | larval stage, with Scer\GAL4insc-Mz1407
larval brain | third instar larval stage
larval dorsal multidendritic neuron ddaC | third instar larval stage
larval multidendritic class IV neuron | third instar larval stage
larval ventral multidendritic neuron vdaA | third instar larval stage
lobe system of adult mushroom body, with Scer\GAL4elav.PU
lobe system of adult mushroom body, with Scer\GAL4ey-OK107
male germ cell nucleus
male pronucleus
mechanosensory chaeta, with Scer\GAL4sca-537.4
medial lobe of adult mushroom body, with Scer\GAL4elav.PU
mesonotum, with Scer\GAL4pnr-MD237
mushroom body vertical lobe | adult stage, with Scer\GAL4elav.PU
ommatidium | somatic clone
ovariole | germline clone
ovary, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
polytene chromosome
polytene chromosome, with Scer\GAL4ey.PH
polytene chromosome (with Iswi1)
polytene chromosome (with Iswi2)
polytene chromosome | male (with Iswi1)
polytene chromosome | male (with Iswi2)
polytene chromosome | male limited (with Iswi1)
polytene chromosome | male limited (with Iswi2)
spermatid, with Scer\GAL4path-c135
spermatozoon
spermatozoon, with Scer\GAL4path-c135
wing blade, with Scer\GAL4en.PU
wing disc (with Iswi1)
wing disc (with Iswi2)
wing pouch | larval stage, with Scer\GAL4ptc-559.1
X chromosome | male
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (30)
Hsap\SMARCA1
14 of 14
Yes
Yes
 
1  
Hsap\SMARCA5
12 of 14
No
Yes
 
3  
Hsap\HELLS
4 of 14
No
Yes
Hsap\CHD1L
3 of 14
No
Yes
Hsap\BTAF1
2 of 14
No
No
Hsap\SMARCAD1
2 of 14
No
No
Hsap\ATRX
1 of 14
No
No
Hsap\CHD1
1 of 14
No
No
Hsap\CHD2
1 of 14
No
No
Hsap\CHD3
1 of 14
No
No
Hsap\CHD4
1 of 14
No
No
Hsap\CHD5
1 of 14
No
No
Hsap\CHD6
1 of 14
No
No
Hsap\CHD7
1 of 14
No
No
1  
Hsap\CHD8
1 of 14
No
No
Hsap\CHD9
1 of 14
No
No
Hsap\EP400
1 of 14
No
No
1  
Hsap\ERCC6
1 of 14
No
Yes
Hsap\ERCC6L2
1 of 14
No
Yes
Hsap\ERCC6L
1 of 14
No
Yes
Hsap\FSBP
1 of 14
No
No
1  
Hsap\HLTF
1 of 14
No
No
Hsap\RAD54B
1 of 14
No
No
Hsap\RAD54L2
1 of 14
No
No
Hsap\RAD54L
1 of 14
No
No
Hsap\SMARCA2
1 of 14
No
No
2  
Hsap\SMARCA4
1 of 14
No
No
Hsap\SMARCAL1
1 of 14
No
No
13  
Hsap\TTF2
1 of 14
No
No
Hsap\ZRANB3
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (26)
Rnor\Smarca1
14 of 14
Yes
Yes
Rnor\Smarca5
12 of 14
No
Yes
Rnor\Hells
4 of 14
No
Yes
Rnor\Chd1l
3 of 14
No
Yes
Rnor\Btaf1
2 of 14
No
No
Rnor\Smarcad1
2 of 14
No
No
Rnor\Chd1
1 of 14
No
No
Rnor\Chd2
1 of 14
No
No
Rnor\Chd3
1 of 14
No
No
Rnor\Chd4
1 of 14
No
No
Rnor\Chd5
1 of 14
No
No
Rnor\Chd6
1 of 14
No
No
Rnor\Chd7
1 of 14
No
No
Rnor\Chd8
1 of 14
No
No
Rnor\Chd9
1 of 14
No
No
Rnor\Ercc6l2
1 of 14
No
Yes
Rnor\Ercc6l
1 of 14
No
Yes
Rnor\Ercc6
1 of 14
No
Yes
Rnor\Fsbp
1 of 14
No
No
Rnor\Rad54b
1 of 14
No
No
Rnor\Rad54l2
1 of 14
No
No
Rnor\Rad54l
1 of 14
No
No
Rnor\Smarca2
1 of 14
No
No
Rnor\Smarca4
1 of 14
No
No
Rnor\Smarcal1
1 of 14
No
No
Rnor\Zranb3
1 of 14
No
No
Mus musculus (laboratory mouse) (27)
Mmus\Smarca1
14 of 14
Yes
Yes
Mmus\Smarca5
12 of 14
No
Yes
Mmus\Hells
4 of 14
No
Yes
Mmus\Btaf1
2 of 14
No
No
Mmus\Chd1l
2 of 14
No
Yes
Mmus\Smarcad1
2 of 14
No
No
Mmus\Atrx
1 of 14
No
No
Mmus\Chd1
1 of 14
No
No
Mmus\Chd2
1 of 14
No
No
Mmus\Chd3
1 of 14
No
No
Mmus\Chd4
1 of 14
No
No
Mmus\Chd5
1 of 14
No
No
Mmus\Chd6
1 of 14
No
No
Mmus\Chd7
1 of 14
No
No
Mmus\Chd8
1 of 14
No
No
Mmus\Chd9
1 of 14
No
No
Mmus\Ercc6l2
1 of 14
No
Yes
Mmus\Ercc6l
1 of 14
No
Yes
Mmus\Ercc6
1 of 14
No
Yes
Mmus\Fsbp
1 of 14
No
No
Mmus\Rad54b
1 of 14
No
No
Mmus\Rad54l2
1 of 14
No
No
Mmus\Rad54l
1 of 14
No
No
Mmus\Smarca2
1 of 14
No
No
Mmus\Smarca4
1 of 14
No
No
Mmus\Smarcal1
1 of 14
No
No
Mmus\Zranb3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (25)
Xtro\smarca1
8 of 13
Yes
Yes
Xtro\smarca5
7 of 13
No
Yes
Xtro\hells
3 of 13
No
Yes
Xtro\smarcad1
2 of 13
No
No
Xtro\adgrf1
1 of 13
No
Yes
Xtro\btaf1
1 of 13
No
No
Xtro\chd1
1 of 13
No
No
Xtro\chd2
1 of 13
No
No
Xtro\chd3
1 of 13
No
No
Xtro\chd6
1 of 13
No
No
Xtro\chd7
1 of 13
No
No
Xtro\chd8
1 of 13
No
No
Xtro\chd9
1 of 13
No
No
Xtro\ep400
1 of 13
No
No
Xtro\ercc6l2
1 of 13
No
Yes
Xtro\ercc6l
1 of 13
No
Yes
Xtro\ercc6
1 of 13
No
Yes
Xtro\rad54b
1 of 13
No
No
Xtro\rad54l2
1 of 13
No
No
Xtro\rad54l
1 of 13
No
No
Xtro\smarca2
1 of 13
No
No
Xtro\smarca4
1 of 13
No
No
Xtro\smarcal1
1 of 13
No
No
Xtro\suclg1
1 of 13
No
No
Xtro\tsku
1 of 13
No
No
Danio rerio (Zebrafish) (29)
Drer\smarca1
14 of 14
Yes
Yes
Drer\smarca5
13 of 14
No
Yes
Drer\chd1l
3 of 14
No
Yes
Drer\hells
3 of 14
No
Yes
Drer\btaf1
2 of 14
No
No
Drer\smarcad1a
2 of 14
No
No
Drer\smarcad1b
2 of 14
No
No
Drer\atrxl
1 of 14
No
No
Drer\chd1
1 of 14
No
No
Drer\chd2
1 of 14
No
No
Drer\chd3
1 of 14
No
No
Drer\chd4a
1 of 14
No
No
Drer\chd4b
1 of 14
No
No
Drer\chd5
1 of 14
No
No
Drer\chd6
1 of 14
No
No
Drer\chd7
1 of 14
No
No
Drer\chd8
1 of 14
No
No
Drer\chd9
1 of 14
No
No
Drer\ercc6
1 of 14
No
Yes
Drer\ercc6l2
1 of 14
No
Yes
Drer\ercc6l
1 of 14
No
Yes
Drer\LOC100535713
1 of 14
No
No
Drer\rad54b
1 of 14
No
No
Drer\rad54l2
1 of 14
No
No
Drer\rad54l
1 of 14
No
No
Drer\smarca2
1 of 14
No
No
Drer\smarca4a
1 of 14
No
No
Drer\smarcal1
1 of 14
No
No
Drer\zranb3
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\isw-1
14 of 14
Yes
Yes
Cele\btf-1
2 of 14
No
No
Cele\chd-1
1 of 14
No
No
Cele\chd-3
1 of 14
No
No
Cele\chd-7
1 of 14
No
No
Cele\csb-1
1 of 14
No
No
Cele\F53H4.6
1 of 14
No
Yes
Cele\F54E12.2
1 of 14
No
No
Cele\let-418
1 of 14
No
No
Cele\M03C11.8
1 of 14
No
No
Cele\pqn-15
1 of 14
No
No
Cele\rad-54.B
1 of 14
No
No
Cele\rad-54.L
1 of 14
No
No
Cele\smrc-1
1 of 14
No
No
Cele\swsn-4
1 of 14
No
No
Cele\T23H2.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (15)
Agam\AgaP_AGAP010700
12 of 12
Yes
Yes
Agam\AgaP_AGAP010699
4 of 12
No
Yes
Agam\AgaP_AGAP001820
2 of 12
No
No
Agam\AgaP_AGAP009980
2 of 12
No
No
Agam\AgaP_AGAP002490
1 of 12
No
No
Agam\AgaP_AGAP006945
1 of 12
No
No
Agam\AgaP_AGAP007573
1 of 12
No
No
Agam\AgaP_AGAP008426
1 of 12
No
No
Agam\AgaP_AGAP008482
1 of 12
No
No
Agam\AgaP_AGAP008698
1 of 12
No
No
Agam\AgaP_AGAP008748
1 of 12
No
No
Agam\AgaP_AGAP009344
1 of 12
No
No
Agam\AgaP_AGAP010462
1 of 12
No
No
Agam\AgaP_AGAP011966
1 of 12
No
No
Agam\AgaP_AGAP012009
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (36)
Atha\CHR11
12 of 13
Yes
Yes
Atha\CHR17
12 of 13
Yes
Yes
Atha\CHR1
4 of 13
No
Yes
Atha\ASG3
3 of 13
No
Yes
Atha\ETL1
2 of 13
No
No
Atha\RGD3
2 of 13
No
No
Atha\AT1G05120
1 of 13
No
No
Atha\AT1G11100
1 of 13
No
No
Atha\AT1G50410
1 of 13
No
No
Atha\AT3G31900
1 of 13
No
No
Atha\AT3G32280
1 of 13
No
No
Atha\AT3G32330
1 of 13
No
No
Atha\AT5G07810
1 of 13
No
No
Atha\AT5G43530
1 of 13
No
No
Atha\ATCHR12
1 of 13
No
No
Atha\ATRX
1 of 13
No
No
Atha\BRM
1 of 13
No
No
Atha\CHR4
1 of 13
No
No
Atha\CHR5
1 of 13
No
No
Atha\CHR8
1 of 13
No
Yes
Atha\CHR18
1 of 13
No
No
Atha\CHR23
1 of 13
No
No
Atha\CHR24
1 of 13
No
Yes
Atha\chr31
1 of 13
No
No
Atha\CHR34
1 of 13
No
No
Atha\CHR38
1 of 13
No
No
Atha\CHR40
1 of 13
No
No
Atha\CHR42
1 of 13
No
No
Atha\DRD1
1 of 13
No
No
Atha\EDA16
1 of 13
No
No
Atha\PKL
1 of 13
No
No
Atha\PKR2
1 of 13
No
No
Atha\RAD5
1 of 13
No
No
Atha\RAD54
1 of 13
No
No
Atha\SWI2
1 of 13
No
Yes
Atha\SYD
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (15)
Scer\ISW1
11 of 13
Yes
Yes
Scer\ISW2
11 of 13
Yes
Yes
Scer\IRC5
2 of 13
No
Yes
Scer\CHD1
1 of 13
No
No
Scer\FUN30
1 of 13
No
No
Scer\INO80
1 of 13
No
No
Scer\IRC20
1 of 13
No
No
Scer\MOT1
1 of 13
No
No
Scer\RAD16
1 of 13
No
No
Scer\RAD26
1 of 13
No
Yes
Scer\RAD54
1 of 13
No
No
Scer\RDH54
1 of 13
No
No
Scer\SNF2
1 of 13
No
No
Scer\STH1
1 of 13
No
No
Scer\ULS1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (12)
Spom\fft1
1 of 12
Yes
No
Spom\fft2
1 of 12
Yes
No
Spom\fft3
1 of 12
Yes
No
Spom\hrp1
1 of 12
Yes
No
Spom\hrp3
1 of 12
Yes
No
Spom\mit1
1 of 12
Yes
No
Spom\mot1
1 of 12
Yes
No
Spom\rdh54
1 of 12
Yes
No
Spom\rhp26
1 of 12
Yes
Yes
Spom\rhp54
1 of 12
Yes
No
Spom\snf21
1 of 12
Yes
No
Spom\snf22
1 of 12
Yes
No
Escherichia coli (enterobacterium) (1)
Ecol\rapA
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Iswi. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
Etl1
5 of 13
Hel89B
5 of 13
brm
4 of 13
CG10445
3 of 13
Chd1
3 of 13
Chd3
3 of 13
kis
3 of 13
lds
3 of 13
Mi-2
3 of 13
okr
3 of 13
XNP
3 of 13
CG4049
2 of 13
dom
2 of 13
Ino80
2 of 13
Marcal1
2 of 13
CG7376
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SMARCA1; SNF2 related chromatin remodeling ATPase 1
14 of 14
300012
       
      SMARCA5; SNF2 related chromatin remodeling ATPase 5
      12 of 14
      SWI/SNF-RELATED, MATRIX-ASSOCIATED, ACTIN-DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 5; SMARCA5
           
          HELLS; helicase, lymphoid specific
          4 of 14
          603946
          CHD1L; chromodomain helicase DNA binding protein 1 like
          3 of 14
          613039
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Dmel gene
              Ortholog showing functional complementation
              Supporting References
              Iswi
              Hsap\SMARCA1
              (Gong et al., 2021)
              Iswi
              Hsap\SMARCA5
              (Gong et al., 2021, Li et al., 2021)
              Interactions
              Summary of Physical Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              Iswi - Acf
              anti bait coimmunoprecipitation, peptide massfingerprinting, ion exchange chromatography, cosedimentation, molecular weight estimation by staining, edman degradation, anti tag coimmunoprecipitation, molecular sieving, western blot, anti tag western blot, pull down
              (Doyen et al., 2015, Emelyanov et al., 2012, Ferreira et al., 2007, Eberharter et al., 2004, Eberharter et al., 2001, Ito et al., 1999, Ito et al., 1997, Varga-Weisz et al., 1997)
              Iswi - CG8677
              anti bait coimmunoprecipitation, western blot
              (Hanai et al., 2008)
              Iswi - CTCF
              anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
              (Bohla et al., 2014)
              Iswi - Caf1-55
              anti bait coimmunoprecipitation, peptide massfingerprinting, western blot, ion exchange chromatography, cosedimentation, molecular weight estimation by staining
              (Doyen et al., 2015, Gdula et al., 1998, Martinez-Balbas et al., 1998, Tsukiyama and Wu, 1995, Tsukiyama et al., 1995)
              Iswi - Chi
              pull down, autoradiography
              (Vanolst et al., 2005)
              Iswi - Chrac-14
              ion exchange chromatography, molecular sieving, western blot, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, peptide massfingerprinting, pull down
              (Doyen et al., 2015, Eberharter et al., 2001, Corona et al., 2000, Varga-Weisz et al., 1997)
              Iswi - Chrac-16
              ion exchange chromatography, molecular sieving, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot
              (Doyen et al., 2015, Eberharter et al., 2001, Corona et al., 2000, Varga-Weisz et al., 1997)
              Iswi - Cp190
              anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
              (Bohla et al., 2014)
              Iswi - CtBP
              ion exchange chromatography, cosedimentation, western blot, anti bait coimmunoprecipitation
              (Emelyanov et al., 2012)
              Iswi - Dref
              anti bait coimmunoprecipitation, western blot
              (Hochheimer et al., 2002)
              Iswi - E(bx)
              anti bait coimmunoprecipitation, western blot, peptide massfingerprinting, ion exchange chromatography, cosedimentation, molecular weight estimation by staining, anti tag coimmunoprecipitation
              (Lam et al., 2019, Doyen et al., 2015, Kwon et al., 2009, Ferreira et al., 2007, Tsukiyama and Wu, 1995, Tsukiyama et al., 1995)
              Iswi - HDAC1
              tandem affinity purification, western blot, anti tag coimmunoprecipitation
              (Burgio et al., 2008)
              Iswi - His3
              pull down, molecular weight estimation by silver staining
              (Wysocka et al., 2006)
              Iswi - His4
              cross-linking study
              (Ludwigsen et al., 2017)
              Iswi - MBD-R2
              coimmunoprecipitation, western blot
              (Lam et al., 2019)
              Iswi - Mst77F
              anti bait coimmunoprecipitation, peptide massfingerprinting
              (Doyen et al., 2015)
              Iswi - Nap1
              anti bait coimmunoprecipitation, western blot
              (Stephens et al., 2006)
              Iswi - Nurf-38
              ion exchange chromatography, cosedimentation, molecular weight estimation by staining, anti bait coimmunoprecipitation, peptide massfingerprinting, western blot
              (Doyen et al., 2015, Gdula et al., 1998, Tsukiyama and Wu, 1995, Tsukiyama et al., 1995)
              Iswi - Pen
              affinity chromatography technology, Identification by mass spectrometry
              (Virágh et al., 2012)
              Iswi - Pi3K92E
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - Rcd5
              anti bait coimmunoprecipitation, western blot
              (Lam et al., 2019)
              Iswi - Rheb
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - Rsf1
              anti bait coimmunoprecipitation, peptide massfingerprinting
              (Doyen et al., 2015)
              Iswi - Sin3A
              anti tag coimmunoprecipitation, western blot, tandem affinity purification
              (Burgio et al., 2008)
              Iswi - Su(var)2-HP2
              anti bait coimmunoprecipitation, western blot
              (Stephens et al., 2006)
              Iswi - Top2
              anti bait coimmunoprecipitation, western blot
              (Varga-Weisz et al., 1997)
              Iswi - Trf2
              anti bait coimmunoprecipitation, western blot, ion exchange chromatography
              (Kopytova et al., 2006, Hochheimer et al., 2002)
              Iswi - Trl
              anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
              (Lomaev et al., 2017, Nakayama et al., 2012)
              Iswi - Tsc1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - arm
              pull down, western blot, autoradiography
              (Song et al., 2009)
              Iswi - dgt1
              anti tag coimmunoprecipitation, western blot
              (Lam et al., 2019)
              Iswi - dikar
              experimental knowledge based
              (Guruharsha et al., 2011)
              Iswi - dom
              anti bait coimmunoprecipitation, western blot
              (Hanai et al., 2008)
              Iswi - foxo
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - gig
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - nsl1
              anti bait coimmunoprecipitation, western blot, pull down
              (Lam et al., 2019)
              Iswi - pnr
              pull down, autoradiography
              (Vanolst et al., 2005)
              Iswi - pzg
              anti bait coimmunoprecipitation, western blot
              (Kugler and Nagel, 2010)
              Iswi - rictor
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - sima
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Iswi - su(Hw)
              anti bait coimmunoprecipitation, western blot
              (Vorobyeva et al., 2021)
              Iswi - tou
              anti bait coimmunoprecipitation, peptide massfingerprinting, anti tag coimmunoprecipitation, ion exchange chromatography, cosedimentation, western blot, molecular weight estimation by staining, anti tag western blot, two hybrid
              (Doyen et al., 2015, Emelyanov et al., 2012, Vanolst et al., 2005)
              RNA-protein
              Physical Interaction
              Assay
              References
              Iswi - lncRNA:Hsrω
              pull down, anti tag western blot, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, electrophoretic mobility shift assay, autoradiography
              (Onorati et al., 2011)
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Iswi
              enhanceable
              Acf
              (Arancio et al., 2010, Burgio et al., 2008)
              Iswi
              suppressible
              casp
              (Arancio et al., 2010)
              Iswi
              enhanceable
              E(bx)
              (Arancio et al., 2010, Burgio et al., 2008)
              Iswi
              suppressible
              eff
              (Arancio et al., 2010)
              Iswi
              enhanceable
              HDAC1
              (Burgio et al., 2008)
              Iswi
              suppressible
              htt
              (Dietz et al., 2015)
              Iswi
              suppressible
              lncRNA:Hsrω
              (Onorati et al., 2011)
              Iswi
              enhanceable
              lncRNA:Hsrω
              (Onorati et al., 2011)
              Iswi
              suppressible
              mbf1
              (Arancio et al., 2010)
              Iswi
              suppressible
              mle
              (Corona et al., 2002)
              Iswi
              enhanceable
              mof
              (Corona et al., 2002)
              Iswi
              enhanceable
              Polr2A
              (Armstrong et al., 2005)
              Iswi
              enhanceable
              Sin3A
              (Burgio et al., 2008)
              Iswi
              enhanceable
              tou
              (Vanolst et al., 2005)
              Iswi
              suppressible
              ttk
              (Arancio et al., 2010)
              Iswi
              suppressible
              wun
              (Arancio et al., 2010)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Chi
              enhanceable
              Iswi
              (Vanolst et al., 2005)
              dlg1
              suppressible
              Iswi
              (Sharp et al., 2021)
              dom
              enhanceable
              Iswi
              (Ellis et al., 2015)
              EcR
              enhanceable
              Iswi
              (Badenhorst et al., 2005)
              foxo
              suppressible
              Iswi
              (Martínez Corrales et al., 2022)
              Marcal1
              suppressible
              Iswi
              (Morimoto et al., 2016)
              pnr
              suppressible
              Iswi
              (Vanolst et al., 2005)
              pnr
              enhanceable
              Iswi
              (Vanolst et al., 2005)
              scf
              suppressible
              Iswi
              (Furuhashi et al., 2006)
              tou
              enhanceable
              Iswi
              (Vanolst et al., 2005)
              TrpA1
              suppressible
              Iswi
              (Gong et al., 2021)
              U2af50
              suppressible
              Iswi
              (Li et al., 2024)
              External Data
              Subunit Structure (UniProtKB)
              Component of the NURF complex composed of Caf1-55, E(bx), Nurf-38 and Iswi (PubMed:8521502). Component of the chromatin accessibility complex (CHRAC), composed of Chrac-14, Chrac-16, Acf and Iswi (PubMed:10856248, PubMed:11447119). Interacts directly with Chrac-14 and this interaction is further stabilized by associated Chrac-16 (PubMed:10856248).
              (UniProt, Q24368 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2R
              Recombination map
              2-67
              Cytogenetic map
              49B10-49B10
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              49B10-49B10
              Limits computationally determined from genome sequence between P{EP}AmphEP2175&P{lacW}spt4k05316 and P{PZ}ox1
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              49B-49C
              (Elfring, 1994.7.19)
              49B-49C
              (determined by in situ hybridisation)
              (Elfring et al., 1994)
              Experimentally Determined Recombination Data
              Location

              2-67

              (FlyBase, 2016)

              2-69.7

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (14)
              Genomic Clones (16)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (197)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Mazina et al., 2018, Lomaev et al., 2017, Riddle et al., 2012, Ferreira et al., 2007, Kal et al., 2000, Ito et al., 1999, Tsukiyama et al., 1995)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 

                • New stable cell line derived from S2-ThermoFischer : Stable S2 cell lines were created to study chromatin remodeling. The base S2[OsTir1] was created and selected core proteins from the four main sub-families of ATP-dependent chromatin remodelers (Snr1, Iswi, Ino80, and Chd1) as well as SWI/SNF component Brd7-9 were inserted to create S2OsTir1-Snr1-AID, S2OsTir1-Iswi-AID, S2OsTir1-Ino80-AID, S2OsTir1-Chd1-AID, and S2OsTir1-Brd7-AID for component depletion studies.

                  (Hendy et al., 2022)
                Other Comments

                Iswi is not required for histone removal during spermatogenesis, but it is required for the stable incorporation of Mst77F and ProtA/ProtB into sperm chromatin. Iswi is not required for the recruitment of histone to the male pronucleus after fertilisation, but is required for the formation of an open chromatin structure after histone deposition.

                (Doyen et al., 2015)

                DNA-protein interactions: genome-wide binding profile assayed for Iswi protein in S2 cells; GEO accession number GSE32404.

                (Moshkin et al., 2012)

                dsRNA has been made from templates generated with primers directed against this gene. RNAi of Iswi results in increased arborization of ddaD and ddaE neurons, defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

                (Parrish et al., 2006)

                Unilateral binding of Iswi protein to a model nucleosome correlates with directional movement of the nucleosome toward the enzyme.

                (Langst and Becker, 2001)

                The NURF complex (composed of Caf1, E(bx), Iswi and Nurf-38 proteins) can remodel chromatin and stimulate transcription in vitro irrespective of the acetylation status of histones.

                (Mizuguchi et al., 2001)

                The Iswi protein per se, out of the context of a multi subunit complex, is able to remodel nucleosomes, rearrange nucleosomal positions and function as a chromatin assembly factor.

                (Corona et al., 1999)

                ACF (ATP-utilizing chromatin assembly and remodeling factor) is a multisubunit factor consisting of 3 polypeptides. These are encoded by Iswi and by Acf1 (this encodes both 170 and 185kD subunits). The p47 polypeptide seen previously in ACF fractions (FBrf0095281) has been found to be identical to Yp2 and appears to have been a contaminant in these earlier ACF fractions.

                (Ito et al., 1999)

                The Acf1 and Iswi subunits of ACF (ATP-utilizing chromatin assembly and remodeling factor) function synergistically in the assembly of chromatin.

                (Ito et al., 1999)

                Trl- and Iswi-mediated disruption of the chromatin structure within the promoter region of ftz activates transcription on the chromatin template.

                (Okada and Hirose, 1998)

                The ATPase activity of Iswi is completely inhibited by each of the four histone tails (His2A, His2B, His3 and His4), results indicate a novel role for the flexible histone tails in chromatin remodeling by Iswi.

                (Georgel et al., 1997)

                The interaction between Iswi and nucleosomes is impaired by proteolytic removal of the N-terminal histone tails and by chemical crosslinking of nucleosomal histones.

                (Georgel et al., 1997)

                Acf1, a multisubunit factor consisting of polypeptides with molecular masses of 47, 140, 170 and 185kD, has been purified and characterised. The 140kD component is encoded by Iswi.

                (Ito et al., 1997)

                Once nucleosome remodelling by the DNA binding factor is accomplished a high level of NURF activity is not continuously required for recruitment of the general transcription machinery and transcription initiation. NURF is able to assist gene activation in a chromatin context: remodel nucleosomes for gene activation in chromatin.

                (Mizuguchi et al., 1997)

                NURF, a protein complex of four subunits Caf1, Nurf-38, E(bx) and Iswi, is able to facilitate transcription mediated by a Scer\GAL4 derivative carrying a constitutively activating region from Hsf.

                (Mizuguchi et al., 1997)

                A chromatin-accessibility complex (CHRAC), which uses energy to increase the general accessibility of DNA in chromatin, has been identified. CHRAC can also function during chromatin assembly, using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing.

                (Varga-Weisz et al., 1997)

                The chromatin-accessibility complex (CHRAC) contains 5 subunits, two of which have been identified as the Iswi and Top2 gene products.

                (Varga-Weisz et al., 1997)

                Nucleosome remodelling factor is composed of at least four polypeptides that act in concert with the Trl transcription factor at the Hsp70 promoter. Nucleosome remodelling factor acts directly on the nucleosome to perturb its structure.

                (Tsukiyama and Wu, 1995)

                Iswi encodes the 140kD subunit of Nucleosome remodeling factor.

                (Tsukiyama et al., 1995)

                Identified on the basis of similarity to Scer\snf2.

                (Elfring et al., 1994)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: Iswi anon-EP1279744.124

                (FlyBase, 1996-)
                Additional comments

                Source for merge of Iswi anon-EP1279744.124 was sequence comparison ( date:031211 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (27)
                Reported As
                Symbol Synonym
                ACF
                (Shogren-Knaak et al., 2006, Wu et al., 2006, Alexiadis et al., 2004, Dilworth et al., 2004, An and Roeder, 2003, Alexiadis and Kadonaga, 2002, Levenstein and Kadonaga, 2002, Huang and Kadonaga, 2001, Nakagawa et al., 2001, Ridgway and Almouzni, 2001, Farkas et al., 2000, Jiang et al., 2000)
                CG8625
                (National Institute of Genetics Fly Stocks, 2022-, Çiçek et al., 2016, Suyari et al., 2012, Ni et al., 2010.12.1, Schneiderman et al., 2009, Ni et al., 2008, Casola et al., 2007, Gonzalez-Aguero et al., 2005, Klebes et al., 2005)
                CHRAC
                (Ridgway and Almouzni, 2001, Farkas et al., 2000, Glass and Rosenfeld, 2000, Ridgway and Almouzni, 2000, Di Croce et al., 1999, Guschin and Wolffe, 1999, Jacobson and Pillus, 1999, Kornberg and Lorch, 1999, Langst et al., 1999, Tyler and Kadonaga, 1999, Armstrong and Emerson, 1998, John and Workman, 1998, Kadonaga, 1998, Reinberg et al., 1998, Mizuguchi et al., 1997, Varga-Weisz et al., 1997)
                ISW
                (Cryderman et al., 1999)
                ISWI
                (Jayakrishnan et al., 2025, Fu et al., 2024, Jayakrishnan et al., 2024, Zhimulev et al., 2024, Richards et al., 2022, Zhang et al., 2022, Finger et al., 2021, Gong et al., 2021, Makki and Meller, 2021, Ordway et al., 2021, Vidaurre and Chen, 2021, Vorobyeva et al., 2021, Wolfe et al., 2021, Okimune et al., 2020, Gutierrez-Perez et al., 2019, Lam et al., 2019, Harrer et al., 2018, Khoroshko et al., 2018, Mehrotra and Deshpande, 2018, Khuong et al., 2017, Lo Piccolo et al., 2017, Ludwigsen et al., 2017, Mazina et al., 2017, L Black et al., 2016, Ulianov et al., 2016, Dietz et al., 2015, Dorn and Dorn, 2015, Doyen et al., 2015, Ellis et al., 2015, Fei et al., 2015, Kim et al., 2015, Lieleg et al., 2015, Comoglio and Paro, 2014, Ho et al., 2014, Lee et al., 2014, Messina et al., 2014, Pascual-Garcia et al., 2014, Zhimulev et al., 2014, Collins and Moon, 2013, Dorighi and Tamkun, 2013, Ludwigsen et al., 2013, Morillo Prado et al., 2013, Mueller-Planitz et al., 2013, Clapier and Cairns, 2012, Dunlap et al., 2012, Emelyanov et al., 2012, Fasulo et al., 2012, Forne et al., 2012, Moshkin et al., 2012, Nakayama et al., 2012, Spedale et al., 2012, Virágh et al., 2012, Alkhatib and Landry, 2011, Di Stefano et al., 2011, Kharchenko et al., 2011, Kirilly et al., 2011, Onorati et al., 2011, Sala et al., 2011, Schuettengruber et al., 2011, van Uden et al., 2011, Arancio et al., 2010, Chioda et al., 2010, Emelyanov et al., 2010, Li et al., 2010, Mills, 2010, Prestel et al., 2010, Reddy et al., 2010, Clapier and Cairns, 2009, Henikoff et al., 2009, Kwon et al., 2009, Moshkin et al., 2009, Siriaco et al., 2009, Vorobyeva et al., 2009, Yokoyama et al., 2009, Burgio et al., 2008, Chalkley et al., 2008, Fanti et al., 2008, Hanai et al., 2008, Lagarou et al., 2008, Petesch and Lis, 2008, Sala et al., 2008, Srinivasan et al., 2008, Vorobyeva et al., 2008, Ferreira et al., 2007, Jacquier et al., 2007, Konev et al., 2007, Straub and Becker, 2007, Bouazoune and Brehm, 2006, Furuhashi et al., 2006, Kopytova et al., 2006, Nystul and Spradling, 2006, Parrish et al., 2006, Santoso and Kadonaga, 2006, Stephens et al., 2006, Varga-Weisz and Becker, 2006, Wu et al., 2006, de la Cruz et al., 2005, Kruger, 2005, Kruger, 2005, Lusser et al., 2005, Strohner et al., 2005, Xi and Xie, 2005, Corona and Tamkun, 2004, Eberharter and Becker, 2004, Eberharter et al., 2004, Flaus and Owen-Hughes, 2004, Fyodorov et al., 2004, Taylor-Harding et al., 2004, Grune et al., 2003, Hochheimer and Tjian, 2003, Armstrong et al., 2002, Bonaldi et al., 2002, Corona et al., 2002, Fyodorov and Kadonaga, 2002, Georges et al., 2002, Corona et al., 2001, Eberharter et al., 2001, Mello and Almouzni, 2001, Papoulas et al., 2001, Zaret and Wolffe, 2001, Aalfs and Kingston, 2000, Aasland, 2000, Brehm et al., 2000, Corona et al., 2000, Dilworth et al., 2000, Farkas et al., 2000, Kal et al., 2000, Collins et al., 1999, Cryderman et al., 1999, Ito et al., 1999, Kornberg and Lorch, 1999, Tyler and Kadonaga, 1999, Alexiadis et al., 1998, LeRoy et al., 1998, Martinez-Balbas et al., 1998, Okada and Hirose, 1998, Varga-Weisz et al., 1997, Tsukiyama et al., 1995, Carlson and Laurent, 1994, Elfring, 1994.7.19)
                Iswi
                (Justice et al., 2025, Li et al., 2024, Peng et al., 2024, Cabrita and Martinho, 2023, Yheskel et al., 2023, Andreyeva et al., 2022, Ecovoiu et al., 2022, Gorsi et al., 2022, Hendy et al., 2022, Anqueira-González et al., 2021, Bilder et al., 2021, Kwon et al., 2021, Li et al., 2021, Sureka and Mishra, 2021, Torres-Zelada and Weake, 2021, Kennison, 2020.10.22, Hall et al., 2019, Jiang et al., 2019, Levendosky and Bowman, 2019, Luzhin et al., 2019, Baldi et al., 2018, Rennie et al., 2018, Searle and Pillus, 2018, Yao et al., 2018, Lomaev et al., 2017, Transgenic RNAi Project members, 2017-, Börner and Becker, 2016, Börner et al., 2016, Brewer-Jensen et al., 2016, Du et al., 2016, Morimoto et al., 2016, Zhang et al., 2016, Kwong et al., 2015, Lucchesi and Kuroda, 2015, Nikalayevich and Ohkura, 2015, Gonzalez et al., 2014, Petruk et al., 2013, Nowak et al., 2012, Suyari et al., 2012, Friedman et al., 2011, Gan et al., 2010, Kallappagoudar et al., 2010, Kugler and Nagel, 2010, Li et al., 2010, Wasbrough et al., 2010, Jiang et al., 2009, Carré et al., 2008, Zhou et al., 2008, Bai et al., 2007, Corona et al., 2007, Gabut et al., 2007, Keuling et al., 2007, Matsumoto et al., 2007, Schuettengruber et al., 2007, Cayirlioglu et al., 2003)
                NURF
                (Varga-Weisz and Becker, 2006, Wysocka et al., 2006, Baumann et al., 2003, Shen et al., 2003, Mizuguchi et al., 2001, Ridgway and Almouzni, 2001, Wu, 2001, Farkas et al., 2000, Glass and Rosenfeld, 2000, Jones and Kadonaga, 2000, Di Croce et al., 1999, Jacobson and Pillus, 1999, Kornberg and Lorch, 1999, Tyler and Kadonaga, 1999, Armstrong and Emerson, 1998, Cairns, 1998, Gregory and Horz, 1998, Gregory and Horz, 1998, John and Workman, 1998, Kadonaga, 1998, Luger and Richmond, 1998, Mizzen and Allis, 1998, Reinberg et al., 1998, Wu et al., 1998, Burns and Peterson, 1997, Georgel et al., 1997, Mizuguchi et al., 1997, Tsukiyama and Wu, 1997, Kingston et al., 1996, Peterson, 1996)
                NURF 140
                (Tsukiyama et al., 1995)
                NURF-140
                (Hamiche et al., 1999)
                Nurf-140
                SWI
                (Guschin and Wolffe, 1999)
                anon-EP1279744.124
                dCHRAC
                (Boyer et al., 2000, Peterson, 2000)
                dISWI
                (Endo et al., 2021, Fyodorov and Kadonaga, 2001, Dilworth et al., 2000, Guschin et al., 2000)
                dNURF
                (Emerson, 2002, Fry and Peterson, 2001, Boyer et al., 2000, Peterson, 2000)
                iswi
                (Sharp et al., 2021, Koe et al., 2014, Mengoli et al., 2014, Yan et al., 2014, Zoller and Schulz, 2012, Ables and Drummond-Barbosa, 2010, Mudiganti et al., 2010, Schneiderman et al., 2009, Song et al., 2009, Liu et al., 2008, Shcherbata et al., 2007, Kaeser and Emerson, 2006, Kruger, 2005, Xi and Xie, 2005, Evans et al., 2003, Badenhorst et al., 2002)
                p140
                (Hochheimer et al., 2002)
                p140/ISWI
                (Hochheimer et al., 2002)
                Name Synonyms
                ISWI
                (Singh and Lakhotia, 2012)
                ISWI ATPase
                (Badenhorst et al., 2000)
                Imitation SW
                (Gabut et al., 2007)
                Imitation SWI
                (Comoglio and Paro, 2014, Lee et al., 2014, Xi and Xie, 2005)
                Imitation switch
                (Mengoli et al., 2014)
                Nucleosome remodeling factor
                (Kingston et al., 1996)
                Nucleosome remodeling factor - 140kD
                imitation SWI
                (Nystul and Spradling, 2006)
                imitation switch
                (Song et al., 2009)
                imitation-SWI
                (Elfring, 1994.7.19)
                Secondary FlyBase IDs
                • FBgn0010436
                • FBgn0066055
                Datasets (1)
                Study focus (1)
                Experimental Role
                Project
                Project Type
                Title
                • bait_protein
                modENCODE_chromatin_proteins_cells
                Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 57 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                PDB - An information portal to biological macromolecular structures
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                References (379)