dMsi
RNA binding protein - Notch signaling regulates Msi activity as a translational repressor of Tramtrack in the generation of non-neuronal lineages in during bristle development
Please see the JBrowse view of Dmel\msi for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
4.2, 3.5, 3.0 (northern blot)
606 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\msi using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\msi in JBrowse3-88
3-86.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
msi is required in spermatocytes for correct meiotic chromosome segregation and cytokinesis.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
msi is required for the development of adult external sensory organs (sensilla). msi mutation typically results in extra sockets and/or shafts. It is suggested that the msi phenotype results from transformation of a neuron/glial-precursor cell into a second shaft/socket-precursor cell. It is proposed that the msi protein regulates sensillum development by controlling the expression of target genes at the post-transcriptional level.
The mutant is referred to as musashi, owing to the frequent double-shaft phenotype. Typical samuri warriors used only one sword, Musashi Miyamoto originated the style of fighting using two swords simultaneously.
